ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	9.55471632
2	ribosomal small subunit biogenesis (GO:0042274)	8.87502512
3	peptidyl-histidine modification (GO:0018202)	8.13846362
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	7.20510284
5	ATP synthesis coupled proton transport (GO:0015986)	7.20510284
6	ribosomal small subunit assembly (GO:0000028)	7.08950598
7	viral transcription (GO:0019083)	6.95361674
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.65003399
9	translational termination (GO:0006415)	6.62742245
10	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.62906418
11	maturation of SSU-rRNA (GO:0030490)	5.54748915
12	negative regulation of B cell proliferation (GO:0030889)	5.54551644
13	translational elongation (GO:0006414)	5.54381875
14	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.52939641
15	NADH dehydrogenase complex assembly (GO:0010257)	5.52939641
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.52939641
17	cotranslational protein targeting to membrane (GO:0006613)	5.51857212
18	protein targeting to ER (GO:0045047)	5.44980340
19	regulation of B cell receptor signaling pathway (GO:0050855)	5.36301490
20	maturation of 5.8S rRNA (GO:0000460)	5.35585856
21	protein localization to endoplasmic reticulum (GO:0070972)	5.22298805
22	cellular protein complex disassembly (GO:0043624)	5.18749093
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.17864765
24	viral life cycle (GO:0019058)	4.96585864
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.76194579
26	respiratory electron transport chain (GO:0022904)	4.67341071
27	electron transport chain (GO:0022900)	4.62248611
28	protein complex biogenesis (GO:0070271)	4.53132080
29	translational initiation (GO:0006413)	4.44004989
30	ATP biosynthetic process (GO:0006754)	4.42742429
31	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	4.39498982
32	oxidative phosphorylation (GO:0006119)	4.36553912
33	protein complex disassembly (GO:0043241)	4.22342638
34	mitochondrial respiratory chain complex assembly (GO:0033108)	4.18210369
35	chaperone-mediated protein transport (GO:0072321)	4.15855964
36	translation (GO:0006412)	4.14356139
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.07129912
38	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.00983612
39	negative regulation of alpha-beta T cell activation (GO:0046636)	3.98735873
40	ribosomal large subunit biogenesis (GO:0042273)	3.98636342
41	macromolecular complex disassembly (GO:0032984)	3.94820211
42	positive regulation of phosphatase activity (GO:0010922)	3.91389836
43	regulation of mast cell degranulation (GO:0043304)	3.91259476
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.88123748
45	ncRNA 3-end processing (GO:0043628)	3.84514751
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.77562860
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.66970597
48	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.66655746
49	response to redox state (GO:0051775)	3.66419794
50	apoptotic DNA fragmentation (GO:0006309)	3.61410875
51	regulation of mast cell activation involved in immune response (GO:0033006)	3.60302211
52	regulation of cell maturation (GO:1903429)	3.57150186
53	protein targeting to membrane (GO:0006612)	3.55764342
54	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.55151293
55	negative regulation of leukocyte migration (GO:0002686)	3.48547522
56	mRNA catabolic process (GO:0006402)	3.47568144
57	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.47277631
58	formation of translation preinitiation complex (GO:0001731)	3.41567893
59	DNA replication checkpoint (GO:0000076)	3.41509420
60	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.38276156
61	myelination in peripheral nervous system (GO:0022011)	3.37210435
62	peripheral nervous system axon ensheathment (GO:0032292)	3.37210435
63	positive regulation of meiosis (GO:0045836)	3.33945012
64	cellular component biogenesis (GO:0044085)	3.30208068
65	ribonucleoprotein complex biogenesis (GO:0022613)	3.23478502
66	cellular response to hepatocyte growth factor stimulus (GO:0035729)	3.23287531
67	response to hepatocyte growth factor (GO:0035728)	3.23287531
68	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.20807590
69	negative regulation of exocytosis (GO:0045920)	3.18006318
70	protein neddylation (GO:0045116)	3.17757133
71	nonmotile primary cilium assembly (GO:0035058)	3.16155126
72	DNA deamination (GO:0045006)	3.14899407
73	positive regulation of meiotic cell cycle (GO:0051446)	3.11247653
74	regulation of mast cell activation (GO:0033003)	3.07381155
75	RNA catabolic process (GO:0006401)	3.06063490
76	neuromuscular process controlling posture (GO:0050884)	3.05315402
77	regulation of cilium movement (GO:0003352)	3.02423496
78	hydrogen ion transmembrane transport (GO:1902600)	3.00106293
79	response to dietary excess (GO:0002021)	2.97934934
80	peptidyl-threonine dephosphorylation (GO:0035970)	2.97100982
81	behavioral response to nicotine (GO:0035095)	2.95870119
82	regulation of T cell receptor signaling pathway (GO:0050856)	2.95711182
83	rRNA processing (GO:0006364)	2.88673775
84	nucleoside triphosphate biosynthetic process (GO:0009142)	2.88334617
85	aldehyde catabolic process (GO:0046185)	2.86137578
86	mitochondrial DNA replication (GO:0006264)	2.84905720
87	protein targeting to mitochondrion (GO:0006626)	2.83624233
88	positive regulation of T cell apoptotic process (GO:0070234)	2.83300347
89	negative regulation of fibroblast proliferation (GO:0048147)	2.83238833
90	cellular ketone body metabolic process (GO:0046950)	2.80387190
91	regulation of execution phase of apoptosis (GO:1900117)	2.79637579
92	regulation of microtubule-based movement (GO:0060632)	2.78858293
93	respiratory chain complex IV assembly (GO:0008535)	2.78398639
94	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	2.78169415
95	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.77288123
96	rRNA metabolic process (GO:0016072)	2.73915558
97	platelet dense granule organization (GO:0060155)	2.73031755
98	negative regulation of mast cell activation (GO:0033004)	11.6861914
99	regulation of activation of Janus kinase activity (GO:0010533)	10.5288854
100	negative regulation of phagocytosis (GO:0050765)	10.3349798

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	4.22628407
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.96474628
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.86332771
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.67907668
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.40675881
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.08931021
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.04308420
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.01540260
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.89125147
10	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.84303219
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.81046875
12	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.58091407
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.38886515
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.30717525
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.29096901
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.28711433
17	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.27489796
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.26763337
19	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.26205646
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.25620341
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.18673441
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.17721289
23	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.17315715
24	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.13974986
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.03379035
26	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.97564608
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.88165048
28	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.83507909
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.80578268
30	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.75596571
31	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.72679290
32	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.71251380
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.68852681
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.67978666
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.65975106
36	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.61908878
37	ZNF274_21170338_ChIP-Seq_K562_Hela	1.61732675
38	CTCF_20526341_ChIP-Seq_ESCs_Human	1.58684138
39	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52503980
40	BCL6_27268052_Chip-Seq_Bcells_Human	1.51271299
41	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.49592379
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.48679387
43	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45258282
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.45190217
45	ZNF263_19887448_ChIP-Seq_K562_Human	1.45050233
46	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.42359899
47	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.40746636
48	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.35709637
49	P68_20966046_ChIP-Seq_HELA_Human	1.35641528
50	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.31438977
51	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.30886808
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.30134117
53	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.29795224
54	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.28134542
55	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24327994
56	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.24171424
57	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.22875123
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.22785036
59	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.22332684
60	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.19388985
61	BCOR_27268052_Chip-Seq_Bcells_Human	1.17507128
62	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15703561
63	DCP1A_22483619_ChIP-Seq_HELA_Human	1.14270621
64	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.12915616
65	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12304980
66	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.10971821
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06539413
68	MYC_22102868_ChIP-Seq_BL_Human	1.06530776
69	VDR_23849224_ChIP-Seq_CD4+_Human	1.06182604
70	CTCF_27219007_Chip-Seq_Bcells_Human	1.04619727
71	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.04529446
72	P300_27268052_Chip-Seq_Bcells_Human	1.04400601
73	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.03854619
74	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.02450203
75	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.01158114
76	SA1_27219007_Chip-Seq_Bcells_Human	1.00203237
77	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.99635455
78	E2F1_20622854_ChIP-Seq_HELA_Human	0.99087554
79	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.99085876
80	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.98702388
81	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.96825376
82	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.96529994
83	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94360706
84	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.94330845
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92894619
86	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.92673870
87	NCOR_22424771_ChIP-Seq_293T_Human	0.91764919
88	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91223913
89	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.90321413
90	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.90123568
91	SMC4_20622854_ChIP-Seq_HELA_Human	0.89855830
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.89390051
93	KLF4_19829295_ChIP-Seq_ESCs_Human	0.89085001
94	REST_21632747_ChIP-Seq_MESCs_Mouse	0.88330718
95	E2F7_22180533_ChIP-Seq_HELA_Human	0.88183988
96	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.87877782
97	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.87093650
98	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.86810834
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.86664015
100	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.85940541

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	5.82327349
2	MP0009379_abnormal_foot_pigmentation	5.45537633
3	MP0006292_abnormal_olfactory_placode	3.48481032
4	MP0002163_abnormal_gland_morphology	2.62771240
5	MP0006036_abnormal_mitochondrial_physio	2.41483625
6	MP0008789_abnormal_olfactory_epithelium	2.33074974
7	MP0001485_abnormal_pinna_reflex	2.24116118
8	MP0000015_abnormal_ear_pigmentation	2.20975982
9	MP0010307_abnormal_tumor_latency	2.20408753
10	MP0005174_abnormal_tail_pigmentation	2.14758519
11	MP0004142_abnormal_muscle_tone	2.08338240
12	MP0000049_abnormal_middle_ear	2.04151035
13	MP0003786_premature_aging	1.93574600
14	MP0002160_abnormal_reproductive_system	1.92005382
15	MP0005389_reproductive_system_phenotype	1.89573613
16	MP0003122_maternal_imprinting	1.88145784
17	MP0002653_abnormal_ependyma_morphology	1.83738025
18	MP0004145_abnormal_muscle_electrophysio	1.81431321
19	MP0004742_abnormal_vestibular_system	1.80763937
20	MP0003123_paternal_imprinting	1.73333357
21	MP0005394_taste/olfaction_phenotype	1.70700237
22	MP0005499_abnormal_olfactory_system	1.70700237
23	MP0001919_abnormal_reproductive_system	1.65560189
24	MP0001324_abnormal_eye_pigmentation	1.64650124
25	MP0000678_abnormal_parathyroid_gland	1.64275443
26	MP0003186_abnormal_redox_activity	1.57133224
27	MP0003119_abnormal_digestive_system	1.55632194
28	MP0000343_altered_response_to	1.53221382
29	MP0005379_endocrine/exocrine_gland_phen	1.51176424
30	MP0008932_abnormal_embryonic_tissue	1.44384646
31	MP0003806_abnormal_nucleotide_metabolis	1.42984040
32	MP0005551_abnormal_eye_electrophysiolog	1.41547818
33	MP0001881_abnormal_mammary_gland	1.38845166
34	MP0002234_abnormal_pharynx_morphology	1.37577150
35	MP0002092_abnormal_eye_morphology	1.37510750
36	MP0004858_abnormal_nervous_system	1.33327220
37	MP0006276_abnormal_autonomic_nervous	1.33053213
38	MP0002095_abnormal_skin_pigmentation	1.32502912
39	MP0001529_abnormal_vocalization	1.31081116
40	MP0004133_heterotaxia	1.24203688
41	MP0009745_abnormal_behavioral_response	1.20599439
42	MP0005645_abnormal_hypothalamus_physiol	1.20096591
43	MP0003693_abnormal_embryo_hatching	1.19797969
44	MP0005391_vision/eye_phenotype	1.19567850
45	MP0005266_abnormal_metabolism	1.16523688
46	MP0003635_abnormal_synaptic_transmissio	1.14901987
47	MP0005410_abnormal_fertilization	1.12557710
48	MP0001970_abnormal_pain_threshold	1.11983106
49	MP0008875_abnormal_xenobiotic_pharmacok	1.11350993
50	MP0002733_abnormal_thermal_nociception	1.06000355
51	MP0001661_extended_life_span	1.05221919
52	MP0003183_abnormal_peptide_metabolism	1.03518220
53	MP0003938_abnormal_ear_development	1.02101863
54	MP0003137_abnormal_impulse_conducting	1.00575856
55	MP0002233_abnormal_nose_morphology	0.99840691
56	MP0002332_abnormal_exercise_endurance	0.99054708
57	MP0000569_abnormal_digit_pigmentation	0.98639615
58	MP0005646_abnormal_pituitary_gland	0.97761397
59	MP0002249_abnormal_larynx_morphology	0.93699554
60	MP0000026_abnormal_inner_ear	0.92124850
61	MP0002735_abnormal_chemical_nociception	0.92099271
62	MP0002063_abnormal_learning/memory/cond	0.91898814
63	MP0003943_abnormal_hepatobiliary_system	0.90355477
64	MP0002177_abnormal_outer_ear	0.88884397
65	MP0002277_abnormal_respiratory_mucosa	0.88500787
66	MP0003787_abnormal_imprinting	0.88484163
67	MP0003011_delayed_dark_adaptation	0.87354391
68	MP0004381_abnormal_hair_follicle	0.86320086
69	MP0004130_abnormal_muscle_cell	0.85672007
70	MP0001905_abnormal_dopamine_level	0.84827787
71	MP0003942_abnormal_urinary_system	0.84237448
72	MP0002822_catalepsy	0.83777044
73	MP0001963_abnormal_hearing_physiology	0.83355593
74	MP0002752_abnormal_somatic_nervous	0.82888747
75	MP0004036_abnormal_muscle_relaxation	0.82297750
76	MP0005195_abnormal_posterior_eye	0.82102217
77	MP0002184_abnormal_innervation	0.80320223
78	MP0003121_genomic_imprinting	0.80290899
79	MP0002064_seizures	0.79376930
80	MP0008569_lethality_at_weaning	0.79092075
81	MP0002837_dystrophic_cardiac_calcinosis	0.77574830
82	MP0002734_abnormal_mechanical_nocicepti	0.76007918
83	MP0003937_abnormal_limbs/digits/tail_de	0.74812926
84	MP0005075_abnormal_melanosome_morpholog	0.73145048
85	MP0000955_abnormal_spinal_cord	0.72805647
86	MP0002067_abnormal_sensory_capabilities	0.72457689
87	MP0000631_abnormal_neuroendocrine_gland	0.71982689
88	MP0000490_abnormal_crypts_of	0.71737051
89	MP0001756_abnormal_urination	0.71080238
90	MP0004885_abnormal_endolymph	0.69421294
91	MP0005332_abnormal_amino_acid	0.67732742
92	MP0003755_abnormal_palate_morphology	0.66746940
93	MP0003195_calcinosis	0.66698046
94	MP0005636_abnormal_mineral_homeostasis	0.66458921
95	MP0002638_abnormal_pupillary_reflex	0.65971392
96	MP0002272_abnormal_nervous_system	0.65636243
97	MP0001986_abnormal_taste_sensitivity	0.65357485
98	MP0001293_anophthalmia	0.64369670
99	MP0003879_abnormal_hair_cell	0.63060858
100	MP0009053_abnormal_anal_canal	0.63057370

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	6.85492815
2	Acute necrotizing encephalopathy (HP:0006965)	5.60395949
3	Severe visual impairment (HP:0001141)	5.37476349
4	Abnormal mitochondria in muscle tissue (HP:0008316)	5.15177380
5	Renovascular hypertension (HP:0100817)	4.84763884
6	Testicular atrophy (HP:0000029)	4.84120478
7	Reticulocytopenia (HP:0001896)	4.81441547
8	Progressive macrocephaly (HP:0004481)	4.56451599
9	Acute encephalopathy (HP:0006846)	4.51008931
10	Mitochondrial inheritance (HP:0001427)	4.05439571
11	Impulsivity (HP:0100710)	4.03530202
12	Increased CSF lactate (HP:0002490)	4.01550921
13	Ragged-red muscle fibers (HP:0003200)	3.49119844
14	Myokymia (HP:0002411)	3.44414428
15	Cerebral edema (HP:0002181)	3.43938925
16	Elfin facies (HP:0004428)	3.41592407
17	Bile duct proliferation (HP:0001408)	3.36747073
18	Abnormal biliary tract physiology (HP:0012439)	3.36747073
19	Overriding aorta (HP:0002623)	3.36669956
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.35388064
21	Macrocytic anemia (HP:0001972)	3.29887399
22	Chronic hepatic failure (HP:0100626)	3.27911100
23	Paralysis (HP:0003470)	3.21002799
24	Sensory axonal neuropathy (HP:0003390)	3.14742742
25	Microvesicular hepatic steatosis (HP:0001414)	3.04105635
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.00623596
27	Renal duplication (HP:0000075)	2.98301538
28	Molar tooth sign on MRI (HP:0002419)	2.97998067
29	Abnormality of midbrain morphology (HP:0002418)	2.97998067
30	Abnormality of the diencephalon (HP:0010662)	2.85488359
31	Pallor (HP:0000980)	2.84605398
32	Amblyopia (HP:0000646)	2.84099663
33	Tubulointerstitial abnormality (HP:0001969)	2.81144147
34	Tubulointerstitial nephritis (HP:0001970)	2.80230121
35	Abnormality of the lower motor neuron (HP:0002366)	2.78438003
36	Abnormal number of erythroid precursors (HP:0012131)	2.78085878
37	Abnormality of cells of the erythroid lineage (HP:0012130)	2.75852386
38	Abnormal drinking behavior (HP:0030082)	2.73479807
39	Polydipsia (HP:0001959)	2.73479807
40	Increased hepatocellular lipid droplets (HP:0006565)	2.71234751
41	Pancreatic cysts (HP:0001737)	2.69544611
42	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.66789048
43	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.66789048
44	Tubular atrophy (HP:0000092)	2.65196512
45	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.64670181
46	Dyschromatopsia (HP:0007641)	2.63035185
47	Abnormality of the renal cortex (HP:0011035)	2.54567749
48	Tubulointerstitial fibrosis (HP:0005576)	2.53862009
49	Exercise intolerance (HP:0003546)	2.50484806
50	Hyperacusis (HP:0010780)	2.49148798
51	Flat cornea (HP:0007720)	2.48363232
52	Increased serum lactate (HP:0002151)	2.47162860
53	Hypergonadotropic hypogonadism (HP:0000815)	2.46930533
54	Increased intramyocellular lipid droplets (HP:0012240)	2.44030901
55	Increased serum pyruvate (HP:0003542)	2.42123034
56	Insomnia (HP:0100785)	2.41770797
57	Respiratory failure (HP:0002878)	2.40442880
58	Renal Fanconi syndrome (HP:0001994)	2.38455706
59	Pendular nystagmus (HP:0012043)	2.37570363
60	Pancreatic fibrosis (HP:0100732)	2.35894077
61	Hepatocellular necrosis (HP:0001404)	2.35071023
62	Broad alveolar ridges (HP:0000187)	2.34406111
63	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.34029752
64	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.33018186
65	Leukodystrophy (HP:0002415)	2.21319029
66	Parakeratosis (HP:0001036)	2.19910082
67	Hepatic necrosis (HP:0002605)	2.17936000
68	True hermaphroditism (HP:0010459)	2.17374880
69	Absent/shortened dynein arms (HP:0200106)	2.10793981
70	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.10793981
71	Abnormal rod and cone electroretinograms (HP:0008323)	2.09948900
72	Lipid accumulation in hepatocytes (HP:0006561)	2.09342582
73	Congenital stationary night blindness (HP:0007642)	2.06482266
74	Cystic liver disease (HP:0006706)	2.06259386
75	Optic disc pallor (HP:0000543)	2.06114033
76	Ankle contracture (HP:0006466)	2.05141662
77	Alacrima (HP:0000522)	2.01488205
78	Hyperglycinemia (HP:0002154)	2.00337672
79	Lactic acidosis (HP:0003128)	1.99958449
80	Dysphonia (HP:0001618)	1.96327631
81	Absent thumb (HP:0009777)	1.95075777
82	Polyuria (HP:0000103)	1.89677993
83	Abnormality of glycolysis (HP:0004366)	1.86622905
84	Microretrognathia (HP:0000308)	1.83740317
85	Respiratory difficulties (HP:0002880)	1.79663813
86	Lethargy (HP:0001254)	1.79029780
87	X-linked dominant inheritance (HP:0001423)	1.77877838
88	Increased muscle lipid content (HP:0009058)	1.77041788
89	Anencephaly (HP:0002323)	1.77039650
90	Hyperuricemia (HP:0002149)	1.76854125
91	Increased purine levels (HP:0004368)	1.76854125
92	Colon cancer (HP:0003003)	1.75799364
93	Abnormality of the carotid arteries (HP:0005344)	1.75050031
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.73855915
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.73855915
96	Sclerocornea (HP:0000647)	1.73076281
97	Depressed nasal ridge (HP:0000457)	1.70291772
98	Bifid tongue (HP:0010297)	1.68517340
99	Hyperalaninemia (HP:0003348)	1.67757536
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.67757536

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	7.81877762
2	CDK8	5.03098348
3	CDC42BPA	4.01739998
4	BRSK1	3.86841881
5	NME2	3.69133333
6	CAMKK2	3.33560782
7	SRPK1	2.54834194
8	WNK3	2.40376354
9	MAP3K11	2.37932522
10	TIE1	1.92072166
11	MAP4K1	1.83069274
12	CAMKK1	1.82032028
13	IRAK4	1.80960449
14	SIK2	1.73639685
15	ADRBK2	1.73511419
16	BRSK2	1.54080938
17	CLK1	1.52191187
18	EPHB2	1.45660922
19	GRK1	1.43297643
20	CASK	1.42792942
21	DYRK2	1.42618356
22	MST4	1.40773331
23	AURKA	1.30499251
24	PDK2	1.29136488
25	LRRK2	1.20089654
26	BLK	1.19775371
27	NEK2	1.19531455
28	BCKDK	1.16524094
29	KDR	1.07680688
30	TRIB3	1.06232398
31	MELK	1.04679544
32	MAPK11	0.97807065
33	CAMK1D	0.96766590
34	FRK	0.88866157
35	ABL2	0.88039961
36	CAMK1	0.87877574
37	ERN1	0.79936819
38	BMPR1B	0.78101835
39	WNK4	0.77166907
40	EIF2AK1	0.76812814
41	PKN2	0.74458509
42	DYRK1B	0.69444523
43	TGFBR1	0.68462142
44	PIM2	0.67751156
45	TNK2	0.67204758
46	MINK1	0.65151938
47	CAMK1G	0.63784984
48	CSNK2A2	0.63496285
49	ARAF	0.62740238
50	TXK	0.61908482
51	PTK6	0.61840096
52	CAMK4	0.61255629
53	INSRR	0.60540298
54	CHEK1	0.58430029
55	ROCK2	0.57289678
56	PAK1	0.56728253
57	TLK1	0.56667321
58	BUB1	0.53581096
59	ATR	0.53565086
60	ZAP70	0.53535114
61	EPHA3	0.51639291
62	PLK4	0.50037127
63	AURKB	0.49712360
64	MAPKAPK2	0.49023317
65	PRKCI	0.48507469
66	MAPK12	0.46979022
67	DYRK3	0.45525944
68	PRKD2	0.44829665
69	CSNK2A1	0.44269312
70	CDC7	0.43693234
71	RPS6KA5	0.42913891
72	MARK2	0.42674460
73	ADRBK1	0.40295273
74	STK4	0.39438243
75	ROCK1	0.39115415
76	DAPK2	0.38671757
77	STK11	0.38375509
78	CDK4	0.33049583
79	CSNK1D	0.32482102
80	CDK9	0.32037183
81	ZAK	0.31651483
82	OBSCN	0.31096885
83	PRKACA	0.30693032
84	NTRK2	0.29913983
85	ICK	0.29707806
86	FGR	0.27939722
87	ILK	0.26206777
88	PRKCG	0.25363429
89	CSNK1G2	0.24993844
90	PLK1	0.24791054
91	VRK2	0.24411435
92	ALK	0.23911083
93	MAP4K2	0.23805668
94	CSNK1E	0.23354556
95	MARK1	0.23062042
96	AKT2	0.22207398
97	TESK2	0.22174627
98	CSNK1G3	0.21222278
99	PKN1	0.20551454
100	CDK15	0.19882733

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.68019487
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.13519269
3	Parkinsons disease_Homo sapiens_hsa05012	4.65760414
4	Sulfur relay system_Homo sapiens_hsa04122	4.04706884
5	Alzheimers disease_Homo sapiens_hsa05010	3.20947402
6	Huntingtons disease_Homo sapiens_hsa05016	3.20375747
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.89969966
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.61398153
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30092620
10	RNA polymerase_Homo sapiens_hsa03020	2.22155789
11	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.96214656
12	RNA degradation_Homo sapiens_hsa03018	1.87839894
13	Pyrimidine metabolism_Homo sapiens_hsa00240	1.69616015
14	DNA replication_Homo sapiens_hsa03030	1.66679522
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.62157448
16	Spliceosome_Homo sapiens_hsa03040	1.56923705
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.41615733
18	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.29844283
19	Protein export_Homo sapiens_hsa03060	1.29462689
20	Sulfur metabolism_Homo sapiens_hsa00920	1.28629617
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.26661840
22	Regulation of autophagy_Homo sapiens_hsa04140	1.25294133
23	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.17524638
24	One carbon pool by folate_Homo sapiens_hsa00670	1.14358020
25	Proteasome_Homo sapiens_hsa03050	1.11050510
26	Peroxisome_Homo sapiens_hsa04146	1.10735522
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.09306466
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.05211277
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.02588938
30	Nucleotide excision repair_Homo sapiens_hsa03420	0.98351953
31	Glutathione metabolism_Homo sapiens_hsa00480	0.97988480
32	Purine metabolism_Homo sapiens_hsa00230	0.94503632
33	Homologous recombination_Homo sapiens_hsa03440	0.94225405
34	Metabolic pathways_Homo sapiens_hsa01100	0.92537825
35	Mismatch repair_Homo sapiens_hsa03430	0.91295001
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.90901882
37	Pyruvate metabolism_Homo sapiens_hsa00620	0.82868914
38	Linoleic acid metabolism_Homo sapiens_hsa00591	0.81852408
39	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.81577112
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.79068325
41	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79030865
42	Folate biosynthesis_Homo sapiens_hsa00790	0.78714235
43	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74970886
44	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74243812
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.73727771
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71455607
47	Arginine and proline metabolism_Homo sapiens_hsa00330	0.70993256
48	Fat digestion and absorption_Homo sapiens_hsa04975	0.70198595
49	Fatty acid elongation_Homo sapiens_hsa00062	0.67571680
50	Propanoate metabolism_Homo sapiens_hsa00640	0.64226853
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.59814115
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.59703343
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.59446101
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58288809
55	Basal transcription factors_Homo sapiens_hsa03022	0.57607001
56	Cell cycle_Homo sapiens_hsa04110	0.55913572
57	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.55447951
58	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.55324156
59	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.54704033
60	Nicotine addiction_Homo sapiens_hsa05033	0.53028347
61	Steroid biosynthesis_Homo sapiens_hsa00100	0.52048356
62	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51628142
63	Legionellosis_Homo sapiens_hsa05134	0.51374481
64	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.50434345
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.48815169
66	Butanoate metabolism_Homo sapiens_hsa00650	0.47677858
67	Retinol metabolism_Homo sapiens_hsa00830	0.47098240
68	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46852132
69	RNA transport_Homo sapiens_hsa03013	0.44816532
70	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44266288
71	Base excision repair_Homo sapiens_hsa03410	0.43833375
72	Axon guidance_Homo sapiens_hsa04360	0.41117347
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.38469255
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.38139507
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37871977
76	Phenylalanine metabolism_Homo sapiens_hsa00360	0.37546719
77	Galactose metabolism_Homo sapiens_hsa00052	0.37410556
78	Tryptophan metabolism_Homo sapiens_hsa00380	0.37300009
79	Olfactory transduction_Homo sapiens_hsa04740	0.37190777
80	Tyrosine metabolism_Homo sapiens_hsa00350	0.35105144
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.34795479
82	Malaria_Homo sapiens_hsa05144	0.34026221
83	Phototransduction_Homo sapiens_hsa04744	0.30252674
84	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.29975881
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28937205
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.28164582
87	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.28067943
88	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.27953566
89	Bile secretion_Homo sapiens_hsa04976	0.27667947
90	Fatty acid degradation_Homo sapiens_hsa00071	0.25496132
91	Insulin secretion_Homo sapiens_hsa04911	0.23612589
92	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.22223396
93	Serotonergic synapse_Homo sapiens_hsa04726	0.21830556
94	Allograft rejection_Homo sapiens_hsa05330	0.21591405
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.20933149
96	Taste transduction_Homo sapiens_hsa04742	0.17649565
97	Graft-versus-host disease_Homo sapiens_hsa05332	0.17461920
98	Type I diabetes mellitus_Homo sapiens_hsa04940	0.17131176
99	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.14825088
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.13384054

NDUFS5P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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