NDUFS6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.27030833
2ATP synthesis coupled proton transport (GO:0015986)8.71139239
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.71139239
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.97999374
5* respiratory electron transport chain (GO:0022904)7.74471901
6* electron transport chain (GO:0022900)7.54005766
7oxidative phosphorylation (GO:0006119)6.75197454
8tricarboxylic acid cycle (GO:0006099)5.69948874
9maturation of SSU-rRNA (GO:0030490)5.58155232
10sarcomere organization (GO:0045214)5.29244559
11ATP biosynthetic process (GO:0006754)5.08335935
12viral life cycle (GO:0019058)4.70412644
13protein complex biogenesis (GO:0070271)4.67376538
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.62239026
15regulation of mitochondrial translation (GO:0070129)4.61277780
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60568092
17mitochondrial respiratory chain complex I assembly (GO:0032981)4.60568092
18NADH dehydrogenase complex assembly (GO:0010257)4.60568092
19purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.60380405
20cellular protein complex disassembly (GO:0043624)4.57718125
21purine nucleoside triphosphate biosynthetic process (GO:0009145)4.57492152
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.56382532
23translational initiation (GO:0006413)4.51650085
24heart process (GO:0003015)4.43808320
25heart contraction (GO:0060047)4.43808320
26mitochondrial respiratory chain complex assembly (GO:0033108)4.42340492
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.41550642
28quinone biosynthetic process (GO:1901663)4.40821691
29ubiquinone biosynthetic process (GO:0006744)4.40821691
30ribonucleoprotein complex biogenesis (GO:0022613)4.39009069
31NADH metabolic process (GO:0006734)4.28813206
32cellular component biogenesis (GO:0044085)4.28612202
33cardiac myofibril assembly (GO:0055003)4.28206122
34transcription elongation from RNA polymerase III promoter (GO:0006385)4.26380782
35termination of RNA polymerase III transcription (GO:0006386)4.26380782
36aerobic respiration (GO:0009060)4.24880286
37actin-myosin filament sliding (GO:0033275)4.22021679
38muscle filament sliding (GO:0030049)4.22021679
39hydrogen ion transmembrane transport (GO:1902600)4.18379114
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.11629020
41ribonucleoside triphosphate biosynthetic process (GO:0009201)4.11248668
42myofibril assembly (GO:0030239)3.99468253
43inner mitochondrial membrane organization (GO:0007007)3.98863663
44protein complex disassembly (GO:0043241)3.94927395
45pseudouridine synthesis (GO:0001522)3.90655365
46ubiquinone metabolic process (GO:0006743)3.86891856
47viral transcription (GO:0019083)3.85327174
48ribosomal small subunit assembly (GO:0000028)3.85148952
49negative regulation of ligase activity (GO:0051352)3.83966351
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.83966351
51macromolecular complex disassembly (GO:0032984)3.75512477
52rRNA processing (GO:0006364)3.72606868
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72052061
54pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.71471336
55cardiac muscle contraction (GO:0060048)3.71371788
56translational termination (GO:0006415)3.69891596
57regulation of oxidative phosphorylation (GO:0002082)3.68261226
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68229284
59regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.66155114
60nucleoside triphosphate biosynthetic process (GO:0009142)3.65056415
61pyrimidine nucleotide catabolic process (GO:0006244)3.62363438
62protein targeting to membrane (GO:0006612)3.61489044
63spliceosomal snRNP assembly (GO:0000387)3.60545886
64DNA deamination (GO:0045006)3.60457621
65purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.59989018
66purine nucleoside monophosphate biosynthetic process (GO:0009127)3.59989018
67establishment of protein localization to mitochondrial membrane (GO:0090151)3.59347108
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58873630
69UTP biosynthetic process (GO:0006228)3.58766925
70ribosomal small subunit biogenesis (GO:0042274)3.58338367
71bundle of His cell to Purkinje myocyte communication (GO:0086069)3.58197928
72cardiac muscle cell development (GO:0055013)3.56775603
73rRNA metabolic process (GO:0016072)3.56327248
74proton transport (GO:0015992)3.54774689
75pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.53609599
76succinate metabolic process (GO:0006105)3.53158668
77cardiac muscle tissue morphogenesis (GO:0055008)3.52395590
78rRNA modification (GO:0000154)3.51821873
79mitochondrial transport (GO:0006839)3.51546733
80positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.51486849
81negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.49780419
82proteasome assembly (GO:0043248)3.49354564
83pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.49057058
84hydrogen transport (GO:0006818)3.48408540
85chaperone-mediated protein transport (GO:0072321)3.48168365
86ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.44194672
87guanosine-containing compound biosynthetic process (GO:1901070)3.43981596
88regulation of acyl-CoA biosynthetic process (GO:0050812)3.43919851
89cellular respiration (GO:0045333)3.41464172
90SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40638677
91respiratory chain complex IV assembly (GO:0008535)3.40019333
92nuclear-transcribed mRNA catabolic process (GO:0000956)3.39822147
93translational elongation (GO:0006414)3.38871592
94DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.38571164
95actin-mediated cell contraction (GO:0070252)3.37451336
96branched-chain amino acid catabolic process (GO:0009083)3.35891768
97cotranslational protein targeting to membrane (GO:0006613)3.34767611
98protein targeting to ER (GO:0045047)3.34615045
99cytochrome complex assembly (GO:0017004)3.33462554
100ribosome biogenesis (GO:0042254)3.31870583
101regulation of relaxation of muscle (GO:1901077)3.31798959
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31433405
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31433405
104signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31039900
105signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31039900
106signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31039900
107regulation of skeletal muscle contraction (GO:0014819)3.30840421
108DNA replication checkpoint (GO:0000076)3.30597186
109cardiac cell development (GO:0055006)3.30172375
110CTP biosynthetic process (GO:0006241)3.29794130
111CTP metabolic process (GO:0046036)3.29794130
112base-excision repair, AP site formation (GO:0006285)3.28175533
113regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.28020806
114regulation of cellular respiration (GO:0043457)3.28001609
115oxaloacetate metabolic process (GO:0006107)3.27609643
116UTP metabolic process (GO:0046051)3.27033082
117positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26367351
118signal transduction involved in DNA integrity checkpoint (GO:0072401)3.25867921
119signal transduction involved in DNA damage checkpoint (GO:0072422)3.25867921
120nucleobase-containing small molecule interconversion (GO:0015949)3.25101687
121protein targeting to mitochondrion (GO:0006626)3.25033540
122nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24479537
123telomere maintenance via semi-conservative replication (GO:0032201)3.24426560
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.24398659
125mRNA catabolic process (GO:0006402)3.22394892
126regulation of cofactor metabolic process (GO:0051193)3.21231290
127regulation of coenzyme metabolic process (GO:0051196)3.21231290
128signal transduction involved in cell cycle checkpoint (GO:0072395)3.20393034
129establishment of protein localization to endoplasmic reticulum (GO:0072599)3.20017090
130establishment of protein localization to mitochondrion (GO:0072655)3.19956622
131protein localization to endoplasmic reticulum (GO:0070972)3.19369555
132DNA strand elongation involved in DNA replication (GO:0006271)3.19016443
133pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.18128298
134translation (GO:0006412)3.17610167
135regulation of actin filament-based movement (GO:1903115)3.14894645
136formation of translation preinitiation complex (GO:0001731)3.14826943
137regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.13421878
138muscle tissue morphogenesis (GO:0060415)3.13046831
139adult heart development (GO:0007512)3.12657173
140negative regulation of potassium ion transmembrane transport (GO:1901380)3.09081014
141L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08799780
142protein localization to mitochondrion (GO:0070585)3.06039217
143ventricular cardiac muscle cell action potential (GO:0086005)3.03984114
144iron-sulfur cluster assembly (GO:0016226)3.02612599
145metallo-sulfur cluster assembly (GO:0031163)3.02612599
146ribonucleoside monophosphate biosynthetic process (GO:0009156)3.01725491
147* generation of precursor metabolites and energy (GO:0006091)3.01487011
148aspartate family amino acid catabolic process (GO:0009068)2.99927306
149protein neddylation (GO:0045116)2.99706208
150regulation of cellular amino acid metabolic process (GO:0006521)2.98346550
1512-oxoglutarate metabolic process (GO:0006103)2.95312677
152ribosomal large subunit biogenesis (GO:0042273)2.95296789
153fatty acid beta-oxidation (GO:0006635)2.95024854
154purine nucleoside biosynthetic process (GO:0042451)2.94240122
155purine ribonucleoside biosynthetic process (GO:0046129)2.94240122
156GTP biosynthetic process (GO:0006183)2.92536050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.59421102
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.44484554
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.11479717
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86743818
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.79499769
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.63244266
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.62765524
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43124549
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.38141321
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.33434515
11E2F7_22180533_ChIP-Seq_HELA_Human3.32928974
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.21977464
13* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.21276919
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87121817
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85522201
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.82017847
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67421518
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63214189
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57512927
20* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52058507
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.37152363
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.33733619
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31341647
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30782081
25CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.24561574
26CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.22137986
27* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20446528
28DCP1A_22483619_ChIP-Seq_HELA_Human2.18744203
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12739435
30* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12405197
31VDR_23849224_ChIP-Seq_CD4+_Human1.99489971
32XRN2_22483619_ChIP-Seq_HELA_Human1.95623500
33* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84526673
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.81935817
35* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.80336024
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80294765
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79024947
38FOXP3_21729870_ChIP-Seq_TREG_Human1.71172101
39STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68102388
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67303551
41GABP_19822575_ChIP-Seq_HepG2_Human1.67108454
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.65796500
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55295480
44TTF2_22483619_ChIP-Seq_HELA_Human1.53650287
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45388192
46PPARA_22158963_ChIP-Seq_LIVER_Mouse1.44659122
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43982314
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.43263170
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39240288
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39112271
51KDM5A_27292631_Chip-Seq_BREAST_Human1.38119923
52* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35663937
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.35445354
54ELK1_22589737_ChIP-Seq_MCF10A_Human1.33974734
55FOXM1_23109430_ChIP-Seq_U2OS_Human1.33532079
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30418373
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.30384011
58CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.28680905
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.27359701
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26526376
61ELK1_19687146_ChIP-ChIP_HELA_Human1.26512292
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24462373
63* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24456026
64ZNF263_19887448_ChIP-Seq_K562_Human1.23744476
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.22904773
66* E2F1_21310950_ChIP-Seq_MCF-7_Human1.22361364
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22299081
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21450334
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21041891
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20713548
71GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19493102
72FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18370453
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17076609
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16426157
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14800957
76MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.12539697
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.11978011
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.09808641
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08724945
80CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08368607
81CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08189085
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07341698
83TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06969605
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06419747
85HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05853242
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05667626
87EGR1_23403033_ChIP-Seq_LIVER_Mouse1.05659171
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03825771
89SOX2_18692474_ChIP-Seq_MEFs_Mouse1.03822769
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.03556326
91* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03167014
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01905562
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01444976
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98840200
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95091873
96* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93745845
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.93502680
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92964019
99SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91607694
100* CIITA_25753668_ChIP-Seq_RAJI_Human0.89454877
101MYCN_18555785_ChIP-Seq_MESCs_Mouse0.89362682
102MYC_18940864_ChIP-ChIP_HL60_Human0.88856754
103TET1_21451524_ChIP-Seq_MESCs_Mouse0.88465451
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88236720
105PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86915618
106RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.83652201
107* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.83469178
108AR_21909140_ChIP-Seq_LNCAP_Human0.83246868
109CTCF_26484167_Chip-Seq_Bcells_Mouse0.82859314
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.82191006
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82003217
112BCL6_27268052_Chip-Seq_Bcells_Human0.81863329
113E2F4_17652178_ChIP-ChIP_JURKAT_Human0.81707685
114STAT1_20625510_ChIP-Seq_HELA_Human0.78109568
115NANOG_20526341_ChIP-Seq_ESCs_Human0.77914538
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.77818635
117GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77558679
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76139506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.33499322
2MP0003646_muscle_fatigue5.92752893
3MP0004084_abnormal_cardiac_muscle4.70689608
4MP0004215_abnormal_myocardial_fiber4.11959761
5MP0000751_myopathy3.94885467
6MP0000749_muscle_degeneration3.68501210
7MP0005330_cardiomyopathy3.62333962
8MP0006036_abnormal_mitochondrial_physio3.60934176
9MP0004036_abnormal_muscle_relaxation3.55394542
10MP0008058_abnormal_DNA_repair3.51877580
11MP0003806_abnormal_nucleotide_metabolis3.29572917
12MP0006292_abnormal_olfactory_placode3.17490943
13MP0003111_abnormal_nucleus_morphology2.87616920
14MP0010094_abnormal_chromosome_stability2.83926879
15MP0002972_abnormal_cardiac_muscle2.68296871
16MP0003137_abnormal_impulse_conducting2.56072476
17MP0003077_abnormal_cell_cycle2.52736456
18MP0000750_abnormal_muscle_regeneration2.52409498
19MP0006035_abnormal_mitochondrial_morpho2.46469323
20MP0008775_abnormal_heart_ventricle2.37955730
21MP0003786_premature_aging2.36069458
22MP0004087_abnormal_muscle_fiber2.28177520
23MP0005385_cardiovascular_system_phenoty2.27851597
24MP0001544_abnormal_cardiovascular_syste2.27851597
25MP0003123_paternal_imprinting2.17193845
26MP0003186_abnormal_redox_activity2.16423026
27MP0005620_abnormal_muscle_contractility2.12212183
28MP0002163_abnormal_gland_morphology2.09419871
29MP0008007_abnormal_cellular_replicative1.99163010
30MP0004484_altered_response_of1.98792933
31MP0002106_abnormal_muscle_physiology1.98431389
32MP0002269_muscular_atrophy1.88558165
33MP0006138_congestive_heart_failure1.88510405
34MP0003221_abnormal_cardiomyocyte_apopto1.83632953
35MP0010630_abnormal_cardiac_muscle1.79384206
36MP0003828_pulmonary_edema1.71778414
37MP0009379_abnormal_foot_pigmentation1.65565407
38MP0002332_abnormal_exercise_endurance1.64963367
39MP0003195_calcinosis1.64834813
40MP0010030_abnormal_orbit_morphology1.62426684
41MP0005085_abnormal_gallbladder_physiolo1.62107465
42MP0004130_abnormal_muscle_cell1.60476837
43MP0002938_white_spotting1.57010768
44MP0008789_abnormal_olfactory_epithelium1.55724302
45MP0005266_abnormal_metabolism1.54659636
46MP0005369_muscle_phenotype1.54121088
47MP0002160_abnormal_reproductive_system1.53334493
48MP0004043_abnormal_pH_regulation1.50657089
49MP0004085_abnormal_heartbeat1.49258180
50MP0004145_abnormal_muscle_electrophysio1.46672188
51MP0000759_abnormal_skeletal_muscle1.42689471
52MP0005360_urolithiasis1.41144330
53MP0000049_abnormal_middle_ear1.38399789
54MP0000747_muscle_weakness1.37517028
55MP0002127_abnormal_cardiovascular_syste1.37349672
56MP0005332_abnormal_amino_acid1.37248445
57MP0005083_abnormal_biliary_tract1.35046044
58MP0002139_abnormal_hepatobiliary_system1.34555848
59MP0002736_abnormal_nociception_after1.31789181
60MP0005451_abnormal_body_composition1.31436837
61MP0005670_abnormal_white_adipose1.30233969
62MP0003567_abnormal_fetal_cardiomyocyte1.28442861
63MP0003693_abnormal_embryo_hatching1.25915605
64MP0000678_abnormal_parathyroid_gland1.22780881
65MP0001529_abnormal_vocalization1.21379125
66MP0003950_abnormal_plasma_membrane1.15525492
67MP0008995_early_reproductive_senescence1.14059232
68MP0002653_abnormal_ependyma_morphology1.13972030
69MP0008875_abnormal_xenobiotic_pharmacok1.13327530
70MP0005165_increased_susceptibility_to1.12900631
71MP0005379_endocrine/exocrine_gland_phen1.12090921
72MP0001293_anophthalmia1.10560562
73MP0005319_abnormal_enzyme/_coenzyme1.09933721
74MP0005389_reproductive_system_phenotype1.09761548
75MP0002210_abnormal_sex_determination1.08142237
76MP0000350_abnormal_cell_proliferation1.08005850
77MP0000343_altered_response_to1.07294863
78MP0004858_abnormal_nervous_system1.06364510
79MP0005365_abnormal_bile_salt1.05209203
80MP0004147_increased_porphyrin_level1.04480650
81MP0005394_taste/olfaction_phenotype1.04073099
82MP0005499_abnormal_olfactory_system1.04073099
83MP0000313_abnormal_cell_death1.02874433
84MP0001188_hyperpigmentation0.98255063
85MP0003656_abnormal_erythrocyte_physiolo0.95854853
86MP0005501_abnormal_skin_physiology0.95723786
87MP0005666_abnormal_adipose_tissue0.94559402
88MP0002277_abnormal_respiratory_mucosa0.94001508
89MP0001881_abnormal_mammary_gland0.93335803
90MP0001730_embryonic_growth_arrest0.93090025
91MP0001764_abnormal_homeostasis0.92242001
92MP0001919_abnormal_reproductive_system0.92223426
93MP0006072_abnormal_retinal_apoptosis0.91810240
94MP0000230_abnormal_systemic_arterial0.91549316
95MP0001853_heart_inflammation0.90175447
96MP0005646_abnormal_pituitary_gland0.89421267
97MP0004233_abnormal_muscle_weight0.87949679
98MP0009643_abnormal_urine_homeostasis0.86796191
99MP0009333_abnormal_splenocyte_physiolog0.86447295
100MP0004957_abnormal_blastocyst_morpholog0.86093272
101MP0005584_abnormal_enzyme/coenzyme_acti0.80937160
102MP0002095_abnormal_skin_pigmentation0.80242809
103MP0009840_abnormal_foam_cell0.80232701
104MP0001697_abnormal_embryo_size0.80224947
105MP0005636_abnormal_mineral_homeostasis0.80167260
106MP0001145_abnormal_male_reproductive0.79107848
107MP0005376_homeostasis/metabolism_phenot0.77550532
108MP0009697_abnormal_copulation0.77125376
109MP0005408_hypopigmentation0.77053328
110MP0001485_abnormal_pinna_reflex0.76253872
111MP0002080_prenatal_lethality0.72681416
112MP0005535_abnormal_body_temperature0.71948900
113MP0000358_abnormal_cell_content/0.70998310
114MP0001929_abnormal_gametogenesis0.70725643
115MP0000653_abnormal_sex_gland0.70639321
116MP0009250_abnormal_appendicular_skeleto0.68396611
117MP0009046_muscle_twitch0.67710000
118MP0001666_abnormal_nutrient_absorption0.67394315
119MP0001727_abnormal_embryo_implantation0.66593156
120MP0003938_abnormal_ear_development0.66346458
121MP0003718_maternal_effect0.66200304
122MP0002822_catalepsy0.65892573
123MP0001661_extended_life_span0.65749555
124MP0000490_abnormal_crypts_of0.64571412
125MP0001984_abnormal_olfaction0.63659687
126MP0004510_myositis0.63639950
127MP0002019_abnormal_tumor_incidence0.63453059
128MP0002102_abnormal_ear_morphology0.62754669
129MP0002090_abnormal_vision0.62508919
130MP0002697_abnormal_eye_size0.62090284
131MP0002234_abnormal_pharynx_morphology0.61420692
132MP0009053_abnormal_anal_canal0.61043112
133MP0003121_genomic_imprinting0.60878356
134MP0003136_yellow_coat_color0.60495712
135MP0005084_abnormal_gallbladder_morpholo0.59441014
136MP0002638_abnormal_pupillary_reflex0.59208453
137MP0000266_abnormal_heart_morphology0.59065309
138MP0002078_abnormal_glucose_homeostasis0.56299090
139MP0002118_abnormal_lipid_homeostasis0.55043590
140MP0008932_abnormal_embryonic_tissue0.54604966
141MP0001905_abnormal_dopamine_level0.53143087
142MP0001756_abnormal_urination0.48424778
143MP0003941_abnormal_skin_development0.48376314
144MP0002132_abnormal_respiratory_system0.48005239
145MP0006276_abnormal_autonomic_nervous0.44068677
146MP0004142_abnormal_muscle_tone0.43207633
147MP0003315_abnormal_perineum_morphology0.39505064
148MP0003011_delayed_dark_adaptation0.39118054
149MP0004133_heterotaxia0.37731831
150MP0000372_irregular_coat_pigmentation0.36952183
151MP0009642_abnormal_blood_homeostasis0.36950862
152MP0008469_abnormal_protein_level0.36678661
153MP0005375_adipose_tissue_phenotype0.36506323
154MP0002876_abnormal_thyroid_physiology0.36381512
155MP0004381_abnormal_hair_follicle0.34056060
156MP0000609_abnormal_liver_physiology0.33819365

Predicted human phenotypes

RankGene SetZ-score
1* Acute necrotizing encephalopathy (HP:0006965)6.34606618
2* Abnormal mitochondria in muscle tissue (HP:0008316)6.01361728
3Hepatic necrosis (HP:0002605)5.71672467
4* Mitochondrial inheritance (HP:0001427)5.63997313
5Hepatocellular necrosis (HP:0001404)5.57672074
6* Acute encephalopathy (HP:0006846)5.56623813
7* Progressive macrocephaly (HP:0004481)5.14309018
8* Increased CSF lactate (HP:0002490)5.07788899
9Sudden death (HP:0001699)4.96270007
10Reticulocytopenia (HP:0001896)4.60379508
11Ventricular tachycardia (HP:0004756)4.53629305
12* Cerebral edema (HP:0002181)4.52448376
13Calf muscle hypertrophy (HP:0008981)4.15873556
14Palpitations (HP:0001962)4.14976679
15Decreased activity of mitochondrial respiratory chain (HP:0008972)4.14566965
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.14566965
17Lipid accumulation in hepatocytes (HP:0006561)4.10601869
18* Lactic acidosis (HP:0003128)4.05867321
19Macrocytic anemia (HP:0001972)4.02605729
20Increased hepatocellular lipid droplets (HP:0006565)4.00861508
21Increased intramyocellular lipid droplets (HP:0012240)3.94370937
22Increased muscle lipid content (HP:0009058)3.92262436
23* Respiratory failure (HP:0002878)3.86069957
24* Exercise intolerance (HP:0003546)3.81106878
25Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.81024790
26Muscle hypertrophy of the lower extremities (HP:0008968)3.80451499
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.75202162
28Increased serum lactate (HP:0002151)3.68259924
29Lipoatrophy (HP:0100578)3.58789813
30Myoglobinuria (HP:0002913)3.48617113
31Atrial fibrillation (HP:0005110)3.45669955
32Dicarboxylic aciduria (HP:0003215)3.45561384
33Abnormality of dicarboxylic acid metabolism (HP:0010995)3.45561384
34Exercise-induced muscle cramps (HP:0003710)3.40232150
35Supraventricular tachycardia (HP:0004755)3.28247492
36Exercise-induced myalgia (HP:0003738)3.27701884
37Primary atrial arrhythmia (HP:0001692)3.24662161
38Muscle fiber splitting (HP:0003555)3.23886432
39Abnormality of glycolysis (HP:0004366)3.23152837
40Increased serum pyruvate (HP:0003542)3.23152837
41Renal Fanconi syndrome (HP:0001994)3.21507492
42Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.21066274
43Supraventricular arrhythmia (HP:0005115)3.17354310
44Rhabdomyolysis (HP:0003201)3.14373316
45Dilated cardiomyopathy (HP:0001644)3.12271857
46Generalized aminoaciduria (HP:0002909)3.09057478
47Abnormality of the calf musculature (HP:0001430)3.08658167
48Pallor (HP:0000980)3.02688308
49Abnormality of fatty-acid metabolism (HP:0004359)3.01151879
503-Methylglutaconic aciduria (HP:0003535)2.98475938
51* Lethargy (HP:0001254)2.95542705
52* Optic disc pallor (HP:0000543)2.90863493
53Hypoglycemic coma (HP:0001325)2.85928953
54Conjunctival hamartoma (HP:0100780)2.85517447
55Syncope (HP:0001279)2.82145637
56Ragged-red muscle fibers (HP:0003200)2.80166496
57Aplastic anemia (HP:0001915)2.76728296
58* Leukodystrophy (HP:0002415)2.75650501
59Abnormality of the left ventricular outflow tract (HP:0011103)2.75330295
60Subaortic stenosis (HP:0001682)2.75330295
61Prolonged QT interval (HP:0001657)2.71942409
62Respiratory difficulties (HP:0002880)2.71932667
63Right ventricular cardiomyopathy (HP:0011663)2.70569147
64CNS demyelination (HP:0007305)2.69750797
65Pheochromocytoma (HP:0002666)2.68311127
66Type I transferrin isoform profile (HP:0003642)2.67422580
67Neuroendocrine neoplasm (HP:0100634)2.65767977
68Exertional dyspnea (HP:0002875)2.65010306
69Glycosuria (HP:0003076)2.62675329
70Abnormality of urine glucose concentration (HP:0011016)2.62675329
71Nausea (HP:0002018)2.60240638
72Abnormality of cells of the erythroid lineage (HP:0012130)2.59397888
73Ketoacidosis (HP:0001993)2.58932687
74Microretrognathia (HP:0000308)2.51426576
75Bundle branch block (HP:0011710)2.49158888
76Abnormal number of erythroid precursors (HP:0012131)2.47060574
77Abnormality of alanine metabolism (HP:0010916)2.46586130
78Hyperalaninemia (HP:0003348)2.46586130
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46586130
80Asymmetric septal hypertrophy (HP:0001670)2.44364737
81Myotonia (HP:0002486)2.37966570
82Pancytopenia (HP:0001876)2.37921778
83Esophageal neoplasm (HP:0100751)2.37909011
84Neoplasm of head and neck (HP:0012288)2.37909011
85EMG: myopathic abnormalities (HP:0003458)2.35623334
86Hyperglycinemia (HP:0002154)2.34296456
87Absent thumb (HP:0009777)2.33941755
88Hyporeflexia of lower limbs (HP:0002600)2.30455881
89Hyperglycinuria (HP:0003108)2.29284584
90Heart block (HP:0012722)2.29000941
91Ketosis (HP:0001946)2.28534203
92Methylmalonic aciduria (HP:0012120)2.28462163
93* Vomiting (HP:0002013)2.26261396
94Hyperammonemia (HP:0001987)2.26076549
95Ventricular arrhythmia (HP:0004308)2.25939618
96Testicular atrophy (HP:0000029)2.24949391
97Emotional lability (HP:0000712)2.23715360
98Proximal tubulopathy (HP:0000114)2.22412139
99Cerebral hypomyelination (HP:0006808)2.22360867
100Abnormality of the anterior horn cell (HP:0006802)2.20878397
101Degeneration of anterior horn cells (HP:0002398)2.20878397
102Cleft eyelid (HP:0000625)2.17475979
103Neoplasm of the adrenal gland (HP:0100631)2.17417728
104Ventricular fibrillation (HP:0001663)2.14133745
105Abnormal atrioventricular conduction (HP:0005150)2.13551270
106Multiple enchondromatosis (HP:0005701)2.11657614
107Metabolic acidosis (HP:0001942)2.11618913
108Palmoplantar keratoderma (HP:0000982)2.11344858
109Abnormality of renal resorption (HP:0011038)2.11279193
110Microvesicular hepatic steatosis (HP:0001414)2.09226791
111Progressive muscle weakness (HP:0003323)2.09090098
112Sparse eyelashes (HP:0000653)2.05393560
113Reduced antithrombin III activity (HP:0001976)2.04262972
114Atrioventricular block (HP:0001678)2.03880840
115* X-linked dominant inheritance (HP:0001423)2.01980097
116Hyperphosphaturia (HP:0003109)2.01433115
117Abnormal protein glycosylation (HP:0012346)2.00618613
118Abnormal glycosylation (HP:0012345)2.00618613
119Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00618613
120Abnormal protein N-linked glycosylation (HP:0012347)2.00618613
121Abnormal EKG (HP:0003115)2.00304236
122Abnormality of serum amino acid levels (HP:0003112)2.00150199
123Rough bone trabeculation (HP:0100670)2.00145862
124Left ventricular hypertrophy (HP:0001712)1.98836541
125Oral leukoplakia (HP:0002745)1.96746714
126Hyperthyroidism (HP:0000836)1.91341611
127Birth length less than 3rd percentile (HP:0003561)1.87243801
128Gout (HP:0001997)1.84850913
129Abnormal number of incisors (HP:0011064)1.81163764
130Progressive microcephaly (HP:0000253)1.80304019
131Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79943685
132Gliosis (HP:0002171)1.78952149
133Myokymia (HP:0002411)1.75964030
134Opisthotonus (HP:0002179)1.75648197
135Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74287247
136Horseshoe kidney (HP:0000085)1.65965623
137Trismus (HP:0000211)1.65681795
138* Blindness (HP:0000618)1.65507597
139Abnormality of placental membranes (HP:0011409)1.62151622
140Amniotic constriction ring (HP:0009775)1.62151622
141Methylmalonic acidemia (HP:0002912)1.58281217
142Abnormal urine phosphate concentration (HP:0012599)1.58059706
143Abnormality of reticulocytes (HP:0004312)1.57667931
144Colon cancer (HP:0003003)1.57598770
145Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.57275040
146Pendular nystagmus (HP:0012043)1.56476201
147Death in infancy (HP:0001522)1.56235850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.74220533
2BCKDK4.58303404
3NME24.53107277
4MYLK4.11999167
5CDC73.28601537
6NME13.25621639
7OBSCN3.00892278
8TTN2.99730970
9PDK42.73502684
10PDK32.73502684
11BUB12.47722456
12STK162.41281963
13LMTK22.32926999
14MUSK2.28190253
15PHKG12.17213625
16PHKG22.17213625
17NEK12.07634419
18PINK11.98587226
19EIF2AK11.90613235
20ARAF1.78273626
21PDK21.77101632
22PIK3CA1.76908594
23PIM21.69041740
24ZAK1.60101281
25BRAF1.57966744
26IRAK31.52930802
27TLK11.51064541
28GRK71.49401972
29STK241.47279246
30KDR1.46025089
31WNK41.45268391
32MAPKAPK31.35412296
33ILK1.34220089
34VRK11.32739746
35WEE11.30086114
36EIF2AK31.27711704
37TTK1.26342386
38STK38L1.25434178
39PBK1.22094497
40MAP3K111.21016326
41TIE11.14671346
42DAPK31.13340815
43PLK41.11842791
44CAMK2D1.06311247
45ABL21.01153300
46CHEK20.97249429
47BRSK10.96090141
48STK40.95706487
49SRPK10.92873700
50MAP3K120.92867249
51PLK30.91936186
52MST40.91421774
53CSNK1G30.91215031
54TESK10.87260818
55CCNB10.85585180
56ATR0.85103515
57DAPK10.84688554
58LIMK10.82666171
59RPS6KA40.82058225
60NUAK10.81852460
61SCYL20.76138813
62MAP2K70.75975620
63TESK20.74698343
64CDK80.72780835
65MAP3K30.70774840
66DMPK0.70725383
67CSNK1G20.64984680
68CSNK1G10.63724661
69MAP4K20.63709755
70PAK10.62264203
71CAMK2G0.60777030
72CDK70.60436186
73STK390.58240740
74RPS6KB20.57757442
75RPS6KC10.57505567
76RPS6KL10.57505567
77MST1R0.57274718
78MAPK120.56716774
79AURKA0.55563699
80AURKB0.54595346
81NEK20.54455892
82PAK40.52833663
83CHEK10.52421520
84MAP2K20.52130305
85MAP3K50.51669188
86RPS6KA60.50700865
87DYRK30.49716707
88TAF10.48787787
89CDK190.48583090
90CSNK2A10.47297218
91ROCK10.46339887
92WNK30.45594846
93PRKACA0.45438641
94PKN20.45410252
95CSNK1A1L0.44706738
96TAOK20.44512255
97EPHA20.44301477
98PIK3CG0.44213773
99MAP2K60.44193610
100CSNK1E0.44137330
101GRK50.44067476
102PRKD10.43834233
103CDC42BPA0.42409729
104MAP2K30.42140455
105SMG10.42117328
106MAP3K80.41780623
107CAMK2A0.39124637
108CSNK2A20.39053368
109ADRBK20.39027693
110IRAK20.38309418
111GRK10.37497115
112RPS6KA50.36517680
113IRAK40.36453882
114FLT30.35503690
115MAPKAPK50.34840701
116CDK11A0.33989176
117TSSK60.33525715
118EIF2AK20.33494905
119MINK10.32713549
120CDK140.32687267
121CDK20.31842061
122PAK30.31771040
123TRPM70.30979015
124BRSK20.30452190
125LRRK20.30241610
126PRKACB0.30171987
127NEK90.29986877
128PLK10.29248173
129DYRK20.29163329
130CDK10.29146512
131ATM0.29016822
132CDK40.28525062
133ADRBK10.26564601
134CSNK1A10.26326649
135PRKCG0.25848740
136PKN10.25532490
137PRKACG0.25187931
138CDK150.25131402
139PRKCI0.25107308
140PRKCD0.24757678
141PIM10.24515660
142EPHB20.24040705
143TBK10.22829449
144AKT20.22195083

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.37813807
2Parkinsons disease_Homo sapiens_hsa050124.92178073
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.09068364
4Alzheimers disease_Homo sapiens_hsa050103.44212756
5Huntingtons disease_Homo sapiens_hsa050163.38771505
6Ribosome_Homo sapiens_hsa030103.26641290
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.24073102
8Cardiac muscle contraction_Homo sapiens_hsa042603.23938089
9Proteasome_Homo sapiens_hsa030502.81566694
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.80678473
11Propanoate metabolism_Homo sapiens_hsa006402.51166342
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09795856
13Carbon metabolism_Homo sapiens_hsa012002.04748496
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00050016
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97914884
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.91055974
17Fatty acid degradation_Homo sapiens_hsa000711.85850519
18RNA polymerase_Homo sapiens_hsa030201.83006734
19Pyruvate metabolism_Homo sapiens_hsa006201.79353822
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59043863
21Fatty acid elongation_Homo sapiens_hsa000621.57032167
22Protein export_Homo sapiens_hsa030601.39563756
23Pyrimidine metabolism_Homo sapiens_hsa002401.31729417
24Butanoate metabolism_Homo sapiens_hsa006501.31701432
25Fatty acid metabolism_Homo sapiens_hsa012121.26844774
26Sulfur metabolism_Homo sapiens_hsa009201.22681736
27Fanconi anemia pathway_Homo sapiens_hsa034601.19769252
28Peroxisome_Homo sapiens_hsa041461.16578015
29DNA replication_Homo sapiens_hsa030301.15858117
30Biosynthesis of amino acids_Homo sapiens_hsa012301.13706888
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.11100218
32Folate biosynthesis_Homo sapiens_hsa007901.06761410
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05884197
34Sulfur relay system_Homo sapiens_hsa041221.05428196
35Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03956512
36Phenylalanine metabolism_Homo sapiens_hsa003601.03665626
37Cysteine and methionine metabolism_Homo sapiens_hsa002700.98277743
38Glutathione metabolism_Homo sapiens_hsa004800.97041866
39Mismatch repair_Homo sapiens_hsa034300.95261080
40beta-Alanine metabolism_Homo sapiens_hsa004100.94161560
41* Metabolic pathways_Homo sapiens_hsa011000.94070180
42Tryptophan metabolism_Homo sapiens_hsa003800.93988307
43Dilated cardiomyopathy_Homo sapiens_hsa054140.93032650
44Arginine and proline metabolism_Homo sapiens_hsa003300.90196537
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86172386
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82529092
47Homologous recombination_Homo sapiens_hsa034400.80714301
48Tyrosine metabolism_Homo sapiens_hsa003500.78955921
49Cell cycle_Homo sapiens_hsa041100.77347300
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77004673
51Fructose and mannose metabolism_Homo sapiens_hsa000510.71500881
52Purine metabolism_Homo sapiens_hsa002300.70957031
53Pentose phosphate pathway_Homo sapiens_hsa000300.67709432
54Spliceosome_Homo sapiens_hsa030400.63823219
55PPAR signaling pathway_Homo sapiens_hsa033200.63769337
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63248623
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62907396
58Non-homologous end-joining_Homo sapiens_hsa034500.62318944
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61110733
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60850944
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60587056
62Base excision repair_Homo sapiens_hsa034100.59513861
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58800549
64Vitamin B6 metabolism_Homo sapiens_hsa007500.58622303
65Nucleotide excision repair_Homo sapiens_hsa034200.57767857
66Galactose metabolism_Homo sapiens_hsa000520.57730773
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57443107
68Starch and sucrose metabolism_Homo sapiens_hsa005000.56922763
69Fat digestion and absorption_Homo sapiens_hsa049750.55251554
70Drug metabolism - other enzymes_Homo sapiens_hsa009830.53300723
71Chemical carcinogenesis_Homo sapiens_hsa052040.51748644
72Arginine biosynthesis_Homo sapiens_hsa002200.48982809
73Arachidonic acid metabolism_Homo sapiens_hsa005900.48591805
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47533676
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46816780
76Linoleic acid metabolism_Homo sapiens_hsa005910.46700147
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.46660897
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.44768104
79Systemic lupus erythematosus_Homo sapiens_hsa053220.42976237
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42557150
81Histidine metabolism_Homo sapiens_hsa003400.38609627
82One carbon pool by folate_Homo sapiens_hsa006700.37669412
83N-Glycan biosynthesis_Homo sapiens_hsa005100.37331103
84RNA degradation_Homo sapiens_hsa030180.36808721
85mRNA surveillance pathway_Homo sapiens_hsa030150.36761336
86Steroid biosynthesis_Homo sapiens_hsa001000.36277275
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35248209
88Collecting duct acid secretion_Homo sapiens_hsa049660.35053339
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31266421
90Selenocompound metabolism_Homo sapiens_hsa004500.30915331
91RNA transport_Homo sapiens_hsa030130.30856933
92Viral myocarditis_Homo sapiens_hsa054160.27333749
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27062975
94Retinol metabolism_Homo sapiens_hsa008300.23987048
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22832919
96p53 signaling pathway_Homo sapiens_hsa041150.22600480
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22170831
98Basal transcription factors_Homo sapiens_hsa030220.21886229
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.19430169
100Regulation of autophagy_Homo sapiens_hsa041400.18807553
101Oocyte meiosis_Homo sapiens_hsa041140.15191413
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.14687102
103Vibrio cholerae infection_Homo sapiens_hsa051100.14002475
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13453473
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.11808906
106Vitamin digestion and absorption_Homo sapiens_hsa049770.10654337
107Phototransduction_Homo sapiens_hsa047440.09718596
108Synaptic vesicle cycle_Homo sapiens_hsa047210.09599258
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07994321
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.07724116
111Alcoholism_Homo sapiens_hsa050340.07436962
112Legionellosis_Homo sapiens_hsa051340.02710641
113Glycerolipid metabolism_Homo sapiens_hsa005610.02537197
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.01053855
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.00756029
116Caffeine metabolism_Homo sapiens_hsa002320.00748910
117Glucagon signaling pathway_Homo sapiens_hsa04922-0.0186903
118Epstein-Barr virus infection_Homo sapiens_hsa05169-0.0139789

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