NDUFS7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.61585668
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.04342885
3ATP synthesis coupled proton transport (GO:0015986)8.04342885
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)7.74255441
5* respiratory electron transport chain (GO:0022904)7.26197463
6* electron transport chain (GO:0022900)7.07684163
7oxidative phosphorylation (GO:0006119)5.89622543
8tricarboxylic acid cycle (GO:0006099)5.65284734
9regulation of somitogenesis (GO:0014807)5.39320402
10* protein complex biogenesis (GO:0070271)5.15258596
11NADH metabolic process (GO:0006734)5.07051112
12* mitochondrial respiratory chain complex I assembly (GO:0032981)5.03765372
13* NADH dehydrogenase complex assembly (GO:0010257)5.03765372
14* mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.03765372
15* mitochondrial respiratory chain complex assembly (GO:0033108)4.90817731
16regulation of mitochondrial translation (GO:0070129)4.83220311
17ubiquinone biosynthetic process (GO:0006744)4.76497008
18quinone biosynthetic process (GO:1901663)4.76497008
19ATP biosynthetic process (GO:0006754)4.72118533
20inner mitochondrial membrane organization (GO:0007007)4.46911830
21sarcomere organization (GO:0045214)4.37801338
22heart contraction (GO:0060047)4.31881770
23heart process (GO:0003015)4.31881770
24respiratory chain complex IV assembly (GO:0008535)4.30768099
25DNA deamination (GO:0045006)4.24485863
26deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.23605915
27hydrogen ion transmembrane transport (GO:1902600)4.23244475
28ubiquinone metabolic process (GO:0006743)4.18379463
29purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.16393536
30chaperone-mediated protein transport (GO:0072321)4.15920765
31sulfation (GO:0051923)4.13133680
32purine nucleoside triphosphate biosynthetic process (GO:0009145)4.12611973
33aerobic respiration (GO:0009060)4.08656058
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.98724583
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.97711775
36cytochrome complex assembly (GO:0017004)3.96383380
37GDP-mannose metabolic process (GO:0019673)3.94851901
38regulation of acyl-CoA biosynthetic process (GO:0050812)3.92226751
39positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.91033962
40actin-myosin filament sliding (GO:0033275)3.85017569
41muscle filament sliding (GO:0030049)3.85017569
42succinate metabolic process (GO:0006105)3.78753959
43ribonucleoside triphosphate biosynthetic process (GO:0009201)3.73170251
44proton transport (GO:0015992)3.71316044
45viral mRNA export from host cell nucleus (GO:0046784)3.70145925
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.69451269
47hydrogen transport (GO:0006818)3.64822200
48regulation of relaxation of muscle (GO:1901077)3.62707880
49regulation of cofactor metabolic process (GO:0051193)3.58366011
50regulation of coenzyme metabolic process (GO:0051196)3.58366011
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57386342
52oxaloacetate metabolic process (GO:0006107)3.56018017
53pseudouridine synthesis (GO:0001522)3.55145583
54myofibril assembly (GO:0030239)3.54584315
55regulation of skeletal muscle contraction (GO:0014819)3.53909113
56cardiac myofibril assembly (GO:0055003)3.52980240
57proteasome assembly (GO:0043248)3.48877057
58regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.45562454
59DNA integration (GO:0015074)3.44009672
60mitochondrial transport (GO:0006839)3.42669244
61positive regulation of prostaglandin secretion (GO:0032308)3.40367902
62regulation of oxidative phosphorylation (GO:0002082)3.39713547
63heparin biosynthetic process (GO:0030210)3.33152724
64heparin metabolic process (GO:0030202)3.33152724
65cellular respiration (GO:0045333)3.32597600
66purine nucleoside monophosphate biosynthetic process (GO:0009127)3.32410301
67purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.32410301
68metallo-sulfur cluster assembly (GO:0031163)3.30106032
69iron-sulfur cluster assembly (GO:0016226)3.30106032
70L-methionine salvage (GO:0071267)3.29441976
71L-methionine biosynthetic process (GO:0071265)3.29441976
72amino acid salvage (GO:0043102)3.29441976
73regulation of cellular respiration (GO:0043457)3.29409835
74cardiac muscle contraction (GO:0060048)3.28911806
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.27275946
76protein targeting to mitochondrion (GO:0006626)3.27082931
77nucleoside triphosphate biosynthetic process (GO:0009142)3.26068380
78regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.23794860
79establishment of protein localization to mitochondrion (GO:0072655)3.21381321
80peptidyl-histidine modification (GO:0018202)3.17101977
81branched-chain amino acid catabolic process (GO:0009083)3.15010236
82creatine metabolic process (GO:0006600)3.10821143
83negative regulation of B cell apoptotic process (GO:0002903)3.09021290
84heme biosynthetic process (GO:0006783)3.07870264
85water-soluble vitamin biosynthetic process (GO:0042364)3.07441033
86DNA replication-dependent nucleosome assembly (GO:0006335)3.04955814
87DNA replication-dependent nucleosome organization (GO:0034723)3.04955814
88regulation of cell communication by electrical coupling (GO:0010649)3.03705091
89cytidine metabolic process (GO:0046087)3.00962329
90cytidine catabolic process (GO:0006216)3.00962329
91cytidine deamination (GO:0009972)3.00962329
92regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.00287509
93rRNA modification (GO:0000154)3.00273990
94base-excision repair, AP site formation (GO:0006285)2.98947341
95actin-mediated cell contraction (GO:0070252)2.97950099
96protein localization to mitochondrion (GO:0070585)2.96929005
97* generation of precursor metabolites and energy (GO:0006091)2.95402122
98quinone metabolic process (GO:1901661)2.95132216
99regulation of actin filament-based movement (GO:1903115)2.95079789
100replicative senescence (GO:0090399)2.92918540
101ribosomal small subunit assembly (GO:0000028)2.91242643
102positive regulation of action potential (GO:0045760)2.90118623
103transcription elongation from RNA polymerase III promoter (GO:0006385)2.88246894
104termination of RNA polymerase III transcription (GO:0006386)2.88246894
105positive regulation of mitochondrial fission (GO:0090141)2.87127881
106mitochondrial membrane organization (GO:0007006)2.83477851
107positive regulation of potassium ion transmembrane transport (GO:1901381)2.82912443
108pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82329909
109mitochondrion morphogenesis (GO:0070584)2.81697582
110purine ribonucleoside biosynthetic process (GO:0046129)2.81337288
111purine nucleoside biosynthetic process (GO:0042451)2.81337288
112cardiac muscle tissue morphogenesis (GO:0055008)2.80978145
113protein neddylation (GO:0045116)2.80518267
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.75734517
115ribonucleoside monophosphate biosynthetic process (GO:0009156)2.75720703
116aspartate family amino acid catabolic process (GO:0009068)2.75118906
117fatty acid beta-oxidation (GO:0006635)2.74021167
118positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.73419362
119regulation of striated muscle contraction (GO:0006942)2.71565008
120regulation of sulfur metabolic process (GO:0042762)2.70805567
121skeletal muscle contraction (GO:0003009)2.70540726
122striated muscle contraction (GO:0006941)2.70034230
123ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.69778843
124energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.69410857
125ATP hydrolysis coupled proton transport (GO:0015991)2.69410857
126regulation of action potential (GO:0098900)2.69114716
127sarcoplasmic reticulum calcium ion transport (GO:0070296)2.68128410
128nucleotide salvage (GO:0043173)2.63214005
129mannosylation (GO:0097502)2.62765310
130skeletal muscle fiber development (GO:0048741)2.62654962
131cardiac muscle hypertrophy (GO:0003300)2.62069576
132GTP biosynthetic process (GO:0006183)2.58432326
133cellular potassium ion homeostasis (GO:0030007)2.57525410
134muscle hypertrophy (GO:0014896)2.56401851
135tRNA modification (GO:0006400)2.54314926
136intracellular protein transmembrane import (GO:0044743)2.54038135
137positive regulation of TOR signaling (GO:0032008)2.53984872
138regulation of membrane repolarization (GO:0060306)2.52619933
139purine nucleotide salvage (GO:0032261)2.50423813
140myotube cell development (GO:0014904)2.49655364
141striated muscle hypertrophy (GO:0014897)2.49154971
142peroxisome fission (GO:0016559)2.48011203
143response to misfolded protein (GO:0051788)2.47023454
144rRNA methylation (GO:0031167)2.46881253
145purine deoxyribonucleotide catabolic process (GO:0009155)2.45600490
146negative regulation of telomere maintenance (GO:0032205)2.43642242

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44206838
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.92456335
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.76789761
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.74652806
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.54517372
6SRF_21415370_ChIP-Seq_HL-1_Mouse3.50024888
7ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.47307854
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.27162804
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.25418673
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.21757022
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.20523302
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.11127382
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.10564880
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08338282
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03379550
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94722772
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.84016872
18* YY1_21170310_ChIP-Seq_MESCs_Mouse2.83159511
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69487822
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65732578
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58823839
22* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.51700675
23DCP1A_22483619_ChIP-Seq_HELA_Human2.44499739
24* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.34096514
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.32039991
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.29209479
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28794492
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23210227
29* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18239667
30* XRN2_22483619_ChIP-Seq_HELA_Human2.12805591
31BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.12761197
32* VDR_23849224_ChIP-Seq_CD4+_Human2.04155172
33* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.99560576
34* VDR_21846776_ChIP-Seq_THP-1_Human1.96390781
35* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90266432
36* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90138940
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87155250
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.86200136
39* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.84924384
40* TTF2_22483619_ChIP-Seq_HELA_Human1.76018666
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.70930664
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67175150
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.66429388
44* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64794960
45* P68_20966046_ChIP-Seq_HELA_Human1.61770774
46* FOXP3_21729870_ChIP-Seq_TREG_Human1.56607513
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54139278
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53142287
49* LXR_22292898_ChIP-Seq_THP-1_Human1.49303476
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48435757
51* GABP_19822575_ChIP-Seq_HepG2_Human1.46748341
52* BCOR_27268052_Chip-Seq_Bcells_Human1.42468262
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.42207691
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.40711738
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36312819
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35818141
57* E2F1_20622854_ChIP-Seq_HELA_Human1.35405242
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35162120
59PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31045636
60PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.30897887
61* PHF8_20622854_ChIP-Seq_HELA_Human1.30712519
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30411622
63* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30307033
64CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29817900
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29188307
66* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28795673
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.27906231
68CIITA_25753668_ChIP-Seq_RAJI_Human1.26783903
69YY1_22570637_ChIP-Seq_MALME-3M_Human1.23730638
70GATA1_22025678_ChIP-Seq_K562_Human1.22116801
71MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21889722
72STAT1_20625510_ChIP-Seq_HELA_Human1.20719864
73CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15349431
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15158128
75* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15118154
76EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14812406
77CTCF_21964334_Chip-Seq_Bcells_Human1.14744934
78* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14529641
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14039705
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.13619977
81* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12095301
82SA1_27219007_Chip-Seq_Bcells_Human1.11947687
83* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11489877
84MAF_26560356_Chip-Seq_TH2_Human1.11353185
85CTCF_20526341_ChIP-Seq_ESCs_Human1.10875583
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.09661104
87ELK1_22589737_ChIP-Seq_MCF10A_Human1.09185325
88* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08661340
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08035385
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07831557
91* P300_27268052_Chip-Seq_Bcells_Human1.07268674
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.07156526
93GATA4_21415370_ChIP-Seq_HL-1_Mouse1.07065593
94CTCF_27219007_Chip-Seq_Bcells_Human1.06394791
95HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06351580
96PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06288458
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06190276
98ERA_21632823_ChIP-Seq_H3396_Human1.05512049
99SPI1_20517297_ChIP-Seq_HL60_Human1.04521178
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03952356
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.03240795
102CTCF_26484167_Chip-Seq_Bcells_Mouse1.02666192
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01086097
104TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01054400
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00047546
106MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99795417
107* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99761931
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98973229
109* RARA_24833708_ChIP-Seq_LIVER_Mouse0.98581918
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98490275
111EZH2_22144423_ChIP-Seq_EOC_Human0.97078528
112* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96945886
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.95855987
114* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95528660
115SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94398137
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92257245
117* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.92233157
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91886436
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91456406
120KDM5A_27292631_Chip-Seq_BREAST_Human0.90331494
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89907810
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89519781
123* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89462944
124IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88758804
125BCL6_27268052_Chip-Seq_Bcells_Human0.88652967
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.88515983
127NANOG_20526341_ChIP-Seq_ESCs_Human0.88383814
128ZNF263_19887448_ChIP-Seq_K562_Human0.87137910
129NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85781023
130MYC_18940864_ChIP-ChIP_HL60_Human0.83252539
131ELK1_19687146_ChIP-ChIP_HELA_Human0.82235580
132RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.81682760
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81547382
134* ELF1_20517297_ChIP-Seq_JURKAT_Human0.80974855
135* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.80818652
136* FOXP1_21924763_ChIP-Seq_HESCs_Human0.79591279
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.78267031
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77875031
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77418860
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.76946949
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.76335603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.80340342
2MP0002837_dystrophic_cardiac_calcinosis5.58960541
3MP0000751_myopathy4.29853154
4MP0000749_muscle_degeneration3.89431255
5MP0004084_abnormal_cardiac_muscle3.81350001
6MP0004215_abnormal_myocardial_fiber3.68516931
7MP0006036_abnormal_mitochondrial_physio3.59429087
8MP0004036_abnormal_muscle_relaxation3.46863491
9MP0003806_abnormal_nucleotide_metabolis3.19294587
10MP0005330_cardiomyopathy3.04603863
11MP0004147_increased_porphyrin_level2.68570760
12MP0006035_abnormal_mitochondrial_morpho2.51500902
13MP0002138_abnormal_hepatobiliary_system2.42959528
14MP0003137_abnormal_impulse_conducting2.38516496
15MP0002972_abnormal_cardiac_muscle2.22056337
16MP0004484_altered_response_of2.06940278
17MP0005360_urolithiasis2.06815036
18MP0004145_abnormal_muscle_electrophysio2.02318012
19MP0002106_abnormal_muscle_physiology2.01453414
20MP0000750_abnormal_muscle_regeneration1.98575487
21MP0009379_abnormal_foot_pigmentation1.96592731
22MP0005620_abnormal_muscle_contractility1.94952766
23MP0008775_abnormal_heart_ventricle1.94547116
24MP0005171_absent_coat_pigmentation1.93331660
25MP0001529_abnormal_vocalization1.90769513
26MP0004087_abnormal_muscle_fiber1.84626527
27MP0002269_muscular_atrophy1.83249919
28MP0005423_abnormal_somatic_nervous1.79266602
29MP0000747_muscle_weakness1.77455478
30MP0005385_cardiovascular_system_phenoty1.71420351
31MP0001544_abnormal_cardiovascular_syste1.71420351
32MP0005670_abnormal_white_adipose1.65855192
33MP0002160_abnormal_reproductive_system1.64548203
34MP0002163_abnormal_gland_morphology1.60788405
35MP0009046_muscle_twitch1.58808988
36MP0005369_muscle_phenotype1.58360910
37MP0004130_abnormal_muscle_cell1.57034613
38MP0004043_abnormal_pH_regulation1.51496974
39MP0003186_abnormal_redox_activity1.50757867
40MP0009840_abnormal_foam_cell1.49939089
41MP0001502_abnormal_circadian_rhythm1.49744329
42MP0006138_congestive_heart_failure1.46142405
43MP0004085_abnormal_heartbeat1.44227190
44MP0003221_abnormal_cardiomyocyte_apopto1.42944774
45MP0004142_abnormal_muscle_tone1.40593455
46MP0002332_abnormal_exercise_endurance1.40309034
47MP0003656_abnormal_erythrocyte_physiolo1.40190593
48MP0000759_abnormal_skeletal_muscle1.39770768
49MP0000678_abnormal_parathyroid_gland1.36855703
50MP0002735_abnormal_chemical_nociception1.35550428
51MP0005083_abnormal_biliary_tract1.31889087
52MP0009697_abnormal_copulation1.30081857
53MP0002139_abnormal_hepatobiliary_system1.29857605
54MP0005266_abnormal_metabolism1.28722115
55MP0003828_pulmonary_edema1.26981498
56MP0004859_abnormal_synaptic_plasticity1.26743331
57MP0001905_abnormal_dopamine_level1.26192503
58MP0004510_myositis1.24206143
59MP0010630_abnormal_cardiac_muscle1.22816971
60MP0003880_abnormal_central_pattern1.21283082
61MP0005058_abnormal_lysosome_morphology1.16316044
62MP0005332_abnormal_amino_acid1.14862150
63MP0005646_abnormal_pituitary_gland1.12451800
64MP0004270_analgesia1.12369168
65MP0003693_abnormal_embryo_hatching1.10385234
66MP0001970_abnormal_pain_threshold1.06005101
67MP0002272_abnormal_nervous_system1.05923548
68MP0005389_reproductive_system_phenotype1.05233386
69MP0009764_decreased_sensitivity_to1.04521484
70MP0000230_abnormal_systemic_arterial1.03461509
71MP0003635_abnormal_synaptic_transmissio1.00675891
72MP0005584_abnormal_enzyme/coenzyme_acti0.99915122
73MP0006072_abnormal_retinal_apoptosis0.99089893
74MP0005165_increased_susceptibility_to0.94737274
75MP0003950_abnormal_plasma_membrane0.94411351
76MP0003195_calcinosis0.94398734
77MP0001764_abnormal_homeostasis0.94373762
78MP0002822_catalepsy0.94355981
79MP0002733_abnormal_thermal_nociception0.94102695
80MP0008569_lethality_at_weaning0.93914473
81MP0005410_abnormal_fertilization0.89435750
82MP0002127_abnormal_cardiovascular_syste0.88044789
83MP0004233_abnormal_muscle_weight0.86398623
84MP0005319_abnormal_enzyme/_coenzyme0.85555177
85MP0005671_abnormal_response_to0.85523593
86MP0008260_abnormal_autophagy0.85346205
87MP0002736_abnormal_nociception_after0.84491854
88MP0000049_abnormal_middle_ear0.84045113
89MP0005636_abnormal_mineral_homeostasis0.82981183
90MP0003879_abnormal_hair_cell0.81311264
91MP0005379_endocrine/exocrine_gland_phen0.80878802
92MP0005085_abnormal_gallbladder_physiolo0.79431112
93MP0005551_abnormal_eye_electrophysiolog0.76910324
94MP0002064_seizures0.76900037
95MP0001440_abnormal_grooming_behavior0.76403162
96MP0002653_abnormal_ependyma_morphology0.76088514
97MP0000343_altered_response_to0.75522354
98MP0002063_abnormal_learning/memory/cond0.74781822
99MP0005253_abnormal_eye_physiology0.73645442
100MP0001485_abnormal_pinna_reflex0.73583353
101MP0005535_abnormal_body_temperature0.73199292
102MP0005084_abnormal_gallbladder_morpholo0.72593188
103MP0002734_abnormal_mechanical_nocicepti0.72453060
104MP0002572_abnormal_emotion/affect_behav0.72235336
105MP0001486_abnormal_startle_reflex0.71885241
106MP0009643_abnormal_urine_homeostasis0.71533784
107MP0000003_abnormal_adipose_tissue0.71432722
108MP0000358_abnormal_cell_content/0.70649145
109MP0008875_abnormal_xenobiotic_pharmacok0.70134171
110MP0005645_abnormal_hypothalamus_physiol0.69636882
111MP0003011_delayed_dark_adaptation0.69602999
112MP0005376_homeostasis/metabolism_phenot0.68754426
113MP0003567_abnormal_fetal_cardiomyocyte0.68489799
114MP0000920_abnormal_myelination0.68095969
115MP0000685_abnormal_immune_system0.67901942
116MP0004742_abnormal_vestibular_system0.66663538
117MP0001756_abnormal_urination0.66134325
118MP0002638_abnormal_pupillary_reflex0.64558894
119MP0006276_abnormal_autonomic_nervous0.63879330
120MP0005386_behavior/neurological_phenoty0.63141172
121MP0004924_abnormal_behavior0.63141172
122MP0002078_abnormal_glucose_homeostasis0.62087285
123MP0008872_abnormal_physiological_respon0.60541711
124MP0001663_abnormal_digestive_system0.58300446
125MP0005451_abnormal_body_composition0.58213904
126MP0002118_abnormal_lipid_homeostasis0.56826356
127MP0005365_abnormal_bile_salt0.56388894
128MP0003191_abnormal_cellular_cholesterol0.55939616
129MP0000013_abnormal_adipose_tissue0.55464212
130MP0002876_abnormal_thyroid_physiology0.55303081
131MP0001986_abnormal_taste_sensitivity0.54978302
132MP0000372_irregular_coat_pigmentation0.54906965
133MP0005375_adipose_tissue_phenotype0.54644882
134MP0001968_abnormal_touch/_nociception0.54418674
135MP0009745_abnormal_behavioral_response0.53154199
136MP0001664_abnormal_digestion0.52246922
137MP0002229_neurodegeneration0.49810829
138MP0002067_abnormal_sensory_capabilities0.48282343

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.60220775
2Abnormal mitochondria in muscle tissue (HP:0008316)6.31051457
3* Mitochondrial inheritance (HP:0001427)5.90953069
4* Hepatocellular necrosis (HP:0001404)5.85420420
5Acute encephalopathy (HP:0006846)5.69532226
6* Hepatic necrosis (HP:0002605)5.61431393
7Progressive macrocephaly (HP:0004481)5.35983650
8* Increased CSF lactate (HP:0002490)5.27309185
9Oral leukoplakia (HP:0002745)4.68147895
10Cerebral edema (HP:0002181)4.39829019
11* Lactic acidosis (HP:0003128)4.28146700
12Lipid accumulation in hepatocytes (HP:0006561)4.14979409
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.14417859
14Exercise intolerance (HP:0003546)4.06046008
15Increased intramyocellular lipid droplets (HP:0012240)4.02600907
16Increased hepatocellular lipid droplets (HP:0006565)4.02368903
17Increased muscle lipid content (HP:0009058)4.01178377
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.97897551
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.97897551
20* Respiratory failure (HP:0002878)3.97651179
21Sudden death (HP:0001699)3.96265077
22Anomalous pulmonary venous return (HP:0010772)3.88627757
23* Increased serum lactate (HP:0002151)3.78152335
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.67630129
25Muscle fiber inclusion bodies (HP:0100299)3.58657486
26Calf muscle hypertrophy (HP:0008981)3.57367448
27Abnormality of glycolysis (HP:0004366)3.55239817
28Increased serum pyruvate (HP:0003542)3.55239817
29Muscle hypertrophy of the lower extremities (HP:0008968)3.47931539
30Exercise-induced muscle cramps (HP:0003710)3.42953163
31Myoglobinuria (HP:0002913)3.40708993
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.40514528
33Renal Fanconi syndrome (HP:0001994)3.38753617
34Abnormality of the pulmonary veins (HP:0011718)3.36427433
35Exercise-induced myalgia (HP:0003738)3.34562143
36Optic disc pallor (HP:0000543)3.32758835
37Nemaline bodies (HP:0003798)3.30526252
38Palpitations (HP:0001962)3.30203117
39Leukodystrophy (HP:0002415)3.13721582
40Ventricular tachycardia (HP:0004756)3.13085839
41Myopathic facies (HP:0002058)3.08656093
42Rhabdomyolysis (HP:0003201)3.04409235
433-Methylglutaconic aciduria (HP:0003535)3.03041911
44Abnormality of dicarboxylic acid metabolism (HP:0010995)3.02218354
45Dicarboxylic aciduria (HP:0003215)3.02218354
46Rough bone trabeculation (HP:0100670)2.86848880
47Abnormality of fatty-acid metabolism (HP:0004359)2.84820550
48Atrial fibrillation (HP:0005110)2.84309625
49Ragged-red muscle fibers (HP:0003200)2.83637313
50Lipoatrophy (HP:0100578)2.80063240
51Muscle fiber splitting (HP:0003555)2.78447563
52* CNS demyelination (HP:0007305)2.77987539
53Abnormality of alanine metabolism (HP:0010916)2.77222676
54Hyperalaninemia (HP:0003348)2.77222676
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.77222676
56Abnormality of the calf musculature (HP:0001430)2.72209694
57Exertional dyspnea (HP:0002875)2.71442431
58Pheochromocytoma (HP:0002666)2.70271772
59Lethargy (HP:0001254)2.70224588
60Supraventricular tachycardia (HP:0004755)2.69609276
61Myotonia (HP:0002486)2.67639879
62Neuroendocrine neoplasm (HP:0100634)2.67486491
63Primary atrial arrhythmia (HP:0001692)2.62361999
64Supraventricular arrhythmia (HP:0005115)2.59254185
65Dilated cardiomyopathy (HP:0001644)2.54872843
66Muscle stiffness (HP:0003552)2.50484222
67Paralysis (HP:0003470)2.47180770
68Respiratory difficulties (HP:0002880)2.46524634
69Progressive external ophthalmoplegia (HP:0000590)2.43772713
70* Emotional lability (HP:0000712)2.40566299
71Generalized aminoaciduria (HP:0002909)2.37423196
72Syncope (HP:0001279)2.36462913
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.36190750
74Premature graying of hair (HP:0002216)2.34045585
75Abnormality of urine glucose concentration (HP:0011016)2.29470901
76Glycosuria (HP:0003076)2.29470901
77Hemiplegia (HP:0002301)2.24460551
78Vomiting (HP:0002013)2.21894838
79Abnormal trabecular bone morphology (HP:0100671)2.21888611
80Methylmalonic aciduria (HP:0012120)2.21842182
81EMG: myopathic abnormalities (HP:0003458)2.21062752
82Ketoacidosis (HP:0001993)2.14579259
83Abnormality of renal resorption (HP:0011038)2.13391340
84Prolonged QT interval (HP:0001657)2.12444761
85Microvesicular hepatic steatosis (HP:0001414)2.12193468
86Asymmetric septal hypertrophy (HP:0001670)2.08381128
87Testicular atrophy (HP:0000029)2.08360232
88Reduced antithrombin III activity (HP:0001976)2.05853933
89Severe muscular hypotonia (HP:0006829)2.05661721
90Short femoral neck (HP:0100864)2.03463984
91Neoplasm of head and neck (HP:0012288)2.02980271
92Esophageal neoplasm (HP:0100751)2.02980271
93Tongue fasciculations (HP:0001308)2.02974821
94* Gliosis (HP:0002171)1.97110098
95Type 1 muscle fiber predominance (HP:0003803)1.97106088
96Hyporeflexia of lower limbs (HP:0002600)1.96176519
97Cholecystitis (HP:0001082)1.94422256
98Abnormal gallbladder physiology (HP:0012438)1.94422256
99Conjunctival hamartoma (HP:0100780)1.93427583
100Cerebral hypomyelination (HP:0006808)1.93198316
101Type II lissencephaly (HP:0007260)1.92366170
102Squamous cell carcinoma (HP:0002860)1.91994038
103X-linked dominant inheritance (HP:0001423)1.90254327
104Type I transferrin isoform profile (HP:0003642)1.90163671
105Abnormal number of erythroid precursors (HP:0012131)1.90053801
106Abnormality of cells of the erythroid lineage (HP:0012130)1.90019660
107Hyperglycinuria (HP:0003108)1.89956323
108Ketosis (HP:0001946)1.89629876
109Methylmalonic acidemia (HP:0002912)1.89193805
110Left ventricular hypertrophy (HP:0001712)1.88483341
111Unsteady gait (HP:0002317)1.86325536
112Hyperammonemia (HP:0001987)1.85796864
113Progressive muscle weakness (HP:0003323)1.85686009
114Hypoglycemic coma (HP:0001325)1.85640713
115Ventricular arrhythmia (HP:0004308)1.85303534
116Distal arthrogryposis (HP:0005684)1.85070960
117Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.85061450
118Cerebral palsy (HP:0100021)1.84858831
119Abnormal EKG (HP:0003115)1.83697636
120Metabolic acidosis (HP:0001942)1.83450643
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82414289
122Progressive microcephaly (HP:0000253)1.81188896
123Centrally nucleated skeletal muscle fibers (HP:0003687)1.80728881
124Subaortic stenosis (HP:0001682)1.80508087
125Abnormality of the left ventricular outflow tract (HP:0011103)1.80508087
126Abnormal protein glycosylation (HP:0012346)1.79528629
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.79528629
128Abnormal protein N-linked glycosylation (HP:0012347)1.79528629
129Abnormal glycosylation (HP:0012345)1.79051753
130Areflexia of lower limbs (HP:0002522)1.78002800
131Muscle fibrillation (HP:0010546)1.74932924
132Hypoplasia of the pons (HP:0012110)1.73883169
133Pendular nystagmus (HP:0012043)1.73201378
134Hypoplasia of the uterus (HP:0000013)1.69790360
135Abnormality of glycolipid metabolism (HP:0010969)1.67721200
136Abnormality of liposaccharide metabolism (HP:0010968)1.67721200
137Abnormality of glycosphingolipid metabolism (HP:0004343)1.67721200
138Microretrognathia (HP:0000308)1.65324141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.74889496
2MYLK3.53198971
3OBSCN3.41917512
4VRK23.37973313
5MUSK2.99549891
6STK162.90848471
7BLK2.78339244
8ARAF2.76482470
9NME12.64854337
10NME22.64747030
11PHKG22.56956764
12PHKG12.56956764
13TLK12.40846931
14LMTK22.40308349
15TTN2.24561613
16ZAK2.23995194
17PDK32.13678285
18PDK42.13678285
19PIM22.13027643
20BRD42.09121466
21MAP3K122.07763827
22VRK11.96902706
23GRK71.93293633
24CDK121.79173621
25PINK11.68976008
26PDK21.66368037
27BUB11.62506010
28NEK11.61712142
29CDK191.61687603
30IRAK31.50501413
31MAP3K111.49906351
32MAP2K71.48245216
33BRAF1.41145913
34GRK11.35957298
35PRKD31.35422775
36EIF2AK31.32937773
37CASK1.32417863
38DAPK21.27962781
39DAPK31.26792876
40CSNK1G31.24334744
41WNK41.18933904
42ERN11.18818958
43TIE11.16484621
44PIK3CA1.14519764
45CSNK1A1L1.13647251
46TESK21.13454701
47CAMK2D1.13405051
48STK391.08768513
49OXSR11.07967559
50GRK51.07372019
51KDR0.97488448
52MAPK130.96975801
53STK40.96258492
54CCNB10.95540933
55CAMK2G0.93464699
56MAP2K30.92236752
57EIF2AK10.92235294
58MAP4K20.91937825
59MAPK110.90065588
60TESK10.89606744
61TSSK60.88207818
62RPS6KL10.87012380
63RPS6KC10.87012380
64CAMK40.86058577
65TEC0.83920828
66SMG10.83608410
67PKN10.82666602
68ILK0.81510932
69CSNK1G20.81457552
70MAPK120.79636383
71CSNK1G10.79104498
72MAPKAPK50.78809412
73RPS6KA60.78068527
74LIMK10.76636903
75IKBKB0.75908284
76TAF10.74558090
77TBK10.70994482
78BMPR1B0.70353169
79STK240.68961483
80MAP4K10.65724302
81WEE10.64290530
82CAMK2A0.63824314
83PRKAA10.63380462
84CDK80.63202584
85CAMKK20.61957342
86TNK20.61713264
87CAMK2B0.59943382
88PAK60.56934659
89ADRBK20.55120658
90ROCK20.54755808
91ABL20.53402101
92AKT20.50931196
93MARK30.49820892
94PRKCI0.48034850
95PRKACA0.46233402
96CDK90.44945115
97ROCK10.44724069
98MAP2K20.44060342
99FLT30.43633679
100PBK0.43331954
101PRKD20.42600929
102PRKCE0.42432835
103SYK0.41973836
104TNIK0.41261945
105NUAK10.40847776
106PIM10.40451816
107TAOK30.39969414
108MAP2K60.39654479
109CAMK10.38406821
110MAP3K30.37121244
111MAP2K40.37073746
112UHMK10.36067294
113RPS6KA50.35887360
114MAPK150.35844657
115INSRR0.35659179
116SIK20.35581218
117PRKD10.35501493
118MAP3K50.35143315
119AURKA0.33983693
120TRIB30.33020922
121MAP3K40.32889548
122PRKCQ0.32849847
123HIPK20.32756517
124PRKG20.32436899
125GRK60.32285111
126DYRK20.30111779
127PRKACB0.29751311
128MAP3K60.29296663
129PDPK10.28772372
130TAOK20.28225579
131RPS6KA20.26509420
132MAPK40.26400020
133PIK3CG0.24587669
134MKNK20.23182587
135KIT0.22693952
136ADRBK10.21117415
137CSNK2A10.20587920
138PAK10.19589617
139DAPK10.19391974
140MAPKAPK30.19120661
141PRKCD0.18308085

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001905.60870678
2Parkinsons disease_Homo sapiens_hsa050124.96851278
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.28605893
4Alzheimers disease_Homo sapiens_hsa050103.59030911
5Huntingtons disease_Homo sapiens_hsa050163.40215694
6Cardiac muscle contraction_Homo sapiens_hsa042603.23808302
7* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.19162854
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91169537
9Alcoholism_Homo sapiens_hsa050342.68717174
10Ribosome_Homo sapiens_hsa030102.57098788
11Propanoate metabolism_Homo sapiens_hsa006402.45704174
12Proteasome_Homo sapiens_hsa030502.43003271
13Fatty acid elongation_Homo sapiens_hsa000622.05083296
14RNA polymerase_Homo sapiens_hsa030202.02160687
15Pyruvate metabolism_Homo sapiens_hsa006202.01706151
16Carbon metabolism_Homo sapiens_hsa012001.98100321
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94691845
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84365739
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.79344478
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.75367605
21Folate biosynthesis_Homo sapiens_hsa007901.74719345
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70474931
23Fatty acid degradation_Homo sapiens_hsa000711.70121118
24Sulfur relay system_Homo sapiens_hsa041221.52498968
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51119982
26Protein export_Homo sapiens_hsa030601.38081214
27Fatty acid metabolism_Homo sapiens_hsa012121.28319763
28Collecting duct acid secretion_Homo sapiens_hsa049661.26572410
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25752912
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.21828831
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20724134
32Peroxisome_Homo sapiens_hsa041461.19927612
33Pyrimidine metabolism_Homo sapiens_hsa002401.19458908
34Butanoate metabolism_Homo sapiens_hsa006501.18041455
35Biosynthesis of amino acids_Homo sapiens_hsa012301.13573356
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09649490
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.08698204
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07534751
39Sulfur metabolism_Homo sapiens_hsa009201.06118150
40Primary immunodeficiency_Homo sapiens_hsa053401.04956515
41* Metabolic pathways_Homo sapiens_hsa011001.03058113
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99195000
43Arginine and proline metabolism_Homo sapiens_hsa003300.96238508
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94180268
45beta-Alanine metabolism_Homo sapiens_hsa004100.93779227
46Fructose and mannose metabolism_Homo sapiens_hsa000510.88488260
47Dilated cardiomyopathy_Homo sapiens_hsa054140.88406882
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87035593
49Maturity onset diabetes of the young_Homo sapiens_hsa049500.84920762
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80159752
51Purine metabolism_Homo sapiens_hsa002300.77710286
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72748256
53DNA replication_Homo sapiens_hsa030300.71507301
54Nicotine addiction_Homo sapiens_hsa050330.71190655
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70447414
56Phenylalanine metabolism_Homo sapiens_hsa003600.70418042
57Fanconi anemia pathway_Homo sapiens_hsa034600.69337038
58Asthma_Homo sapiens_hsa053100.69044046
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68039424
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65914407
61Pentose phosphate pathway_Homo sapiens_hsa000300.64938698
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.63259936
63Insulin secretion_Homo sapiens_hsa049110.63034837
64Mismatch repair_Homo sapiens_hsa034300.61760808
65Glutathione metabolism_Homo sapiens_hsa004800.58685336
66Viral carcinogenesis_Homo sapiens_hsa052030.58612286
67Vibrio cholerae infection_Homo sapiens_hsa051100.57875116
68Tyrosine metabolism_Homo sapiens_hsa003500.57793895
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51777506
70Basal transcription factors_Homo sapiens_hsa030220.50236057
71Homologous recombination_Homo sapiens_hsa034400.48190064
72Tryptophan metabolism_Homo sapiens_hsa003800.47138829
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45176120
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44387981
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44194321
76Base excision repair_Homo sapiens_hsa034100.44134307
77Galactose metabolism_Homo sapiens_hsa000520.43612290
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42828790
79Arachidonic acid metabolism_Homo sapiens_hsa005900.41148014
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40360471
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39554007
82Starch and sucrose metabolism_Homo sapiens_hsa005000.39523967
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.39490118
84Regulation of autophagy_Homo sapiens_hsa041400.39055876
85Morphine addiction_Homo sapiens_hsa050320.38711910
86Nitrogen metabolism_Homo sapiens_hsa009100.36481163
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35322992
88Synaptic vesicle cycle_Homo sapiens_hsa047210.34877537
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34458756
90Salivary secretion_Homo sapiens_hsa049700.34458281
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.34061316
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33901319
93PPAR signaling pathway_Homo sapiens_hsa033200.33556912
94GABAergic synapse_Homo sapiens_hsa047270.33527167
95Nucleotide excision repair_Homo sapiens_hsa034200.32027570
96Histidine metabolism_Homo sapiens_hsa003400.31363300
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31152959
98Lysosome_Homo sapiens_hsa041420.30482964
99Non-homologous end-joining_Homo sapiens_hsa034500.29430386
100Circadian entrainment_Homo sapiens_hsa047130.28880086
101One carbon pool by folate_Homo sapiens_hsa006700.28472108
102Phototransduction_Homo sapiens_hsa047440.28090354
103Gastric acid secretion_Homo sapiens_hsa049710.27861502
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27343027
105RNA degradation_Homo sapiens_hsa030180.27313511
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26774383
107Vitamin B6 metabolism_Homo sapiens_hsa007500.26619485
108Renin secretion_Homo sapiens_hsa049240.26232453
109Oxytocin signaling pathway_Homo sapiens_hsa049210.25370708
110Calcium signaling pathway_Homo sapiens_hsa040200.25196171
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24103405
112Spliceosome_Homo sapiens_hsa030400.23839466
113Vitamin digestion and absorption_Homo sapiens_hsa049770.23291630
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22865201
115Arginine biosynthesis_Homo sapiens_hsa002200.22178002
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21601197
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.20613443
118Systemic lupus erythematosus_Homo sapiens_hsa053220.20293215
119Linoleic acid metabolism_Homo sapiens_hsa005910.19690471
120Fat digestion and absorption_Homo sapiens_hsa049750.19586412
121Rheumatoid arthritis_Homo sapiens_hsa053230.16054913
122Other glycan degradation_Homo sapiens_hsa005110.15357580
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14314461
124Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13848412
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12923911
126Glycerolipid metabolism_Homo sapiens_hsa005610.12140938
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08050123
128Selenocompound metabolism_Homo sapiens_hsa004500.07534436
129Retinol metabolism_Homo sapiens_hsa008300.06875308
130Taste transduction_Homo sapiens_hsa047420.06796483
131Chemical carcinogenesis_Homo sapiens_hsa052040.05974032
132Glucagon signaling pathway_Homo sapiens_hsa049220.05008793

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