NDUFS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.49879976
2ATP synthesis coupled proton transport (GO:0015986)6.04772988
3energy coupled proton transport, down electrochemical gradient (GO:0015985)6.04772988
4oxidative phosphorylation (GO:0006119)5.90611420
5tricarboxylic acid cycle (GO:0006099)5.75443710
6* respiratory electron transport chain (GO:0022904)5.53137565
7* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.49830973
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.41571690
9* electron transport chain (GO:0022900)5.38477501
10NADH metabolic process (GO:0006734)5.32872948
11DNA deamination (GO:0045006)5.19345925
12viral transcription (GO:0019083)4.47176312
13ribosomal small subunit biogenesis (GO:0042274)4.42631279
14translational termination (GO:0006415)4.25206387
15oxaloacetate metabolic process (GO:0006107)4.24455487
16protein maturation by protein folding (GO:0022417)4.21157703
17ribosomal small subunit assembly (GO:0000028)4.16521524
18aerobic respiration (GO:0009060)4.15168759
19regulation of mitochondrial translation (GO:0070129)4.08403769
20transcription elongation from RNA polymerase III promoter (GO:0006385)4.07617577
21termination of RNA polymerase III transcription (GO:0006386)4.07617577
22SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.04583579
23L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.02791228
24translational elongation (GO:0006414)4.01403144
25proteasome assembly (GO:0043248)3.99567853
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.98398546
27cotranslational protein targeting to membrane (GO:0006613)3.96355609
28GTP biosynthetic process (GO:0006183)3.96250558
29protein targeting to ER (GO:0045047)3.94427733
30* protein complex biogenesis (GO:0070271)3.85907323
31succinate metabolic process (GO:0006105)3.84454745
32protein localization to endoplasmic reticulum (GO:0070972)3.81895878
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.75956467
34regulation of oxidative phosphorylation (GO:0002082)3.71863452
35* mitochondrial respiratory chain complex assembly (GO:0033108)3.66339128
36cytochrome complex assembly (GO:0017004)3.65440068
37ATP biosynthetic process (GO:0006754)3.64714620
38translation (GO:0006412)3.64614799
39UTP biosynthetic process (GO:0006228)3.64268121
40quinone biosynthetic process (GO:1901663)3.62986564
41ubiquinone biosynthetic process (GO:0006744)3.62986564
42L-methionine salvage (GO:0071267)3.61280673
43L-methionine biosynthetic process (GO:0071265)3.61280673
44amino acid salvage (GO:0043102)3.61280673
45guanosine-containing compound biosynthetic process (GO:1901070)3.61135500
46respiratory chain complex IV assembly (GO:0008535)3.60923225
47heart contraction (GO:0060047)3.60589205
48heart process (GO:0003015)3.60589205
49regulation of cellular amino acid metabolic process (GO:0006521)3.56666069
50base-excision repair, AP site formation (GO:0006285)3.54771634
51regulation of cellular respiration (GO:0043457)3.52916362
52peptidyl-histidine modification (GO:0018202)3.51697314
53maturation of SSU-rRNA (GO:0030490)3.48034575
54regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.47761351
55* mitochondrial respiratory chain complex I assembly (GO:0032981)3.43901203
56* NADH dehydrogenase complex assembly (GO:0010257)3.43901203
57* mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43901203
58viral life cycle (GO:0019058)3.43443154
59pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.43332656
60negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42443793
61protein neddylation (GO:0045116)3.41942472
62metallo-sulfur cluster assembly (GO:0031163)3.39212656
63iron-sulfur cluster assembly (GO:0016226)3.39212656
64sarcomere organization (GO:0045214)3.38103766
65pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.37904136
66cellular protein complex disassembly (GO:0043624)3.37387931
67RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.37196903
68tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.37196903
69spliceosomal snRNP assembly (GO:0000387)3.34931883
70UTP metabolic process (GO:0046051)3.34395237
71branched-chain amino acid catabolic process (GO:0009083)3.33361238
72cellular respiration (GO:0045333)3.31584341
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30390611
74CTP biosynthetic process (GO:0006241)3.30320738
75CTP metabolic process (GO:0046036)3.30320738
76antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.28794315
77purine nucleoside triphosphate biosynthetic process (GO:0009145)3.28707184
78pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.28426428
79* cellular component biogenesis (GO:0044085)3.27745865
80translational initiation (GO:0006413)3.26918448
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.26799884
82ribosomal large subunit biogenesis (GO:0042273)3.25389444
83inner mitochondrial membrane organization (GO:0007007)3.24123151
84positive regulation of ligase activity (GO:0051351)3.23573825
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.22794900
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22682164
87deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.21409547
88pyrimidine nucleotide catabolic process (GO:0006244)3.20959843
89deoxyribonucleotide catabolic process (GO:0009264)3.19821094
90daunorubicin metabolic process (GO:0044597)3.17990864
91polyketide metabolic process (GO:0030638)3.17990864
92doxorubicin metabolic process (GO:0044598)3.17990864
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17348436
94proton transport (GO:0015992)3.16834470
95regulation of acyl-CoA biosynthetic process (GO:0050812)3.16311762
96intracellular protein transmembrane import (GO:0044743)3.15910273
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.15723983
982-oxoglutarate metabolic process (GO:0006103)3.14675192
99ubiquinone metabolic process (GO:0006743)3.11095435
100negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10541630
101negative regulation of ligase activity (GO:0051352)3.10541630
102antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.09593733
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.08121509
104signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.08121509
105signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.07528552
106signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.07528552
107signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.07528552
108regulation of cofactor metabolic process (GO:0051193)3.07498075
109regulation of coenzyme metabolic process (GO:0051196)3.07498075
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.05333133
111purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.04961282
112purine nucleoside monophosphate biosynthetic process (GO:0009127)3.04961282
113protein targeting to mitochondrion (GO:0006626)3.03179243
114chaperone-mediated protein transport (GO:0072321)3.02521920
115cullin deneddylation (GO:0010388)3.02373394
116hydrogen ion transmembrane transport (GO:1902600)3.02368064
117ribonucleoside triphosphate biosynthetic process (GO:0009201)3.01302342
118protein deneddylation (GO:0000338)2.99747276
119mitochondrial transport (GO:0006839)2.97875468
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96845099
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.96845099
122lysine catabolic process (GO:0006554)2.96146015
123lysine metabolic process (GO:0006553)2.96146015
124branched-chain amino acid metabolic process (GO:0009081)2.94146169
125muscle filament sliding (GO:0030049)2.93208295
126actin-myosin filament sliding (GO:0033275)2.93208295
127establishment of protein localization to mitochondrion (GO:0072655)2.92061219
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91297339
129signal transduction involved in cell cycle checkpoint (GO:0072395)2.90909921
130fatty acid beta-oxidation (GO:0006635)2.90058103
131aldehyde catabolic process (GO:0046185)2.84212940
132tricarboxylic acid metabolic process (GO:0072350)2.81577267
133pseudouridine synthesis (GO:0001522)2.81574898
134aminoglycoside antibiotic metabolic process (GO:0030647)2.79568701
135protein localization to mitochondrion (GO:0070585)2.76603422
136positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.76401094
137nucleoside triphosphate biosynthetic process (GO:0009142)2.76352474
138galactose catabolic process (GO:0019388)2.73877296
139NAD metabolic process (GO:0019674)2.73184609
140GDP-mannose metabolic process (GO:0019673)2.72703541
141telomere maintenance via semi-conservative replication (GO:0032201)2.72686457
142rRNA modification (GO:0000154)2.71039167
143purine nucleobase biosynthetic process (GO:0009113)2.70088908
144ribonucleoside monophosphate biosynthetic process (GO:0009156)2.69409900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.28053416
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.23188115
3* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.92138451
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76477014
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62619704
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.59161003
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.47689498
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.34315883
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.21539758
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17884939
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.88268594
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80956272
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72756551
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70161703
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.65400265
16* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.54188265
17* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.41170175
18* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.29015983
19E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27399440
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.25227081
21VDR_23849224_ChIP-Seq_CD4+_Human2.23505327
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21007010
23YY1_21170310_ChIP-Seq_MESCs_Mouse2.19866876
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16792645
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.15661163
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.07950937
27DCP1A_22483619_ChIP-Seq_HELA_Human2.07913340
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.07185926
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06727649
30E2F7_22180533_ChIP-Seq_HELA_Human2.04139285
31FOXP3_21729870_ChIP-Seq_TREG_Human2.01286643
32* GABP_19822575_ChIP-Seq_HepG2_Human1.94404079
33XRN2_22483619_ChIP-Seq_HELA_Human1.91287110
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90726681
35* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90638960
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89860750
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86115839
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82493851
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78860975
40* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77331735
41* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.77170266
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73391682
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73245584
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72981682
45* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61552408
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.61532232
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.56845758
48MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56819369
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55409606
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53476891
51ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52037763
52PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50001488
53CIITA_25753668_ChIP-Seq_RAJI_Human1.45089932
54TTF2_22483619_ChIP-Seq_HELA_Human1.41963661
55* RXR_22158963_ChIP-Seq_LIVER_Mouse1.39384279
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39057693
57ZNF263_19887448_ChIP-Seq_K562_Human1.38861754
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37843751
59* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.37051063
60ELK1_19687146_ChIP-ChIP_HELA_Human1.36651980
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30633294
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.29384873
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29331079
64CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.27605726
65* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27533476
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27479995
67* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27353254
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24758664
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24362804
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24101851
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.23537832
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23039399
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23013532
74IRF8_22096565_ChIP-ChIP_GC-B_Human1.22771002
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14069058
76RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13660016
77IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11803284
78ELF1_20517297_ChIP-Seq_JURKAT_Human1.10882391
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10057340
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.07169216
81GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06823247
82TBX5_21415370_ChIP-Seq_HL-1_Mouse1.06052966
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03792903
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03570930
85MYCN_18555785_ChIP-Seq_MESCs_Mouse1.03376646
86ELK1_22589737_ChIP-Seq_MCF10A_Human1.02577738
87* P68_20966046_ChIP-Seq_HELA_Human1.01458329
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01321470
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00791414
90* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98731983
91NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98218023
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97870252
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96480471
94* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95964776
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95797396
96FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95255984
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.95050639
98POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93965623
99KDM5A_27292631_Chip-Seq_BREAST_Human0.93246623
100E2F1_21310950_ChIP-Seq_MCF-7_Human0.93167538
101BCL6_27268052_Chip-Seq_Bcells_Human0.91779682
102SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90734564
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90621822
104KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90566302
105SPI1_23547873_ChIP-Seq_NB4_Human0.90441858
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90172962
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.88217999
108PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88216984
109OCT4_18692474_ChIP-Seq_MEFs_Mouse0.87259303
110YY1_22570637_ChIP-Seq_MALME-3M_Human0.86694169
111SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.84950581
112CTCF_20526341_ChIP-Seq_ESCs_Human0.84918455
113CTCF_26484167_Chip-Seq_Bcells_Mouse0.84810331
114TET1_21451524_ChIP-Seq_MESCs_Mouse0.84723380
115* BCOR_27268052_Chip-Seq_Bcells_Human0.84687119
116* PHF8_20622854_ChIP-Seq_HELA_Human0.84286759
117* E2F1_20622854_ChIP-Seq_HELA_Human0.84134673
118* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.82669608
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82028070
120MYC_18940864_ChIP-ChIP_HL60_Human0.81650209
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81137269
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.79806315
123SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79171607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.79324301
2MP0002837_dystrophic_cardiac_calcinosis4.62082545
3MP0003806_abnormal_nucleotide_metabolis3.93345929
4MP0006036_abnormal_mitochondrial_physio3.85787073
5MP0004084_abnormal_cardiac_muscle3.66933501
6MP0004215_abnormal_myocardial_fiber2.99714824
7MP0000749_muscle_degeneration2.97417612
8MP0010030_abnormal_orbit_morphology2.94643454
9MP0004036_abnormal_muscle_relaxation2.78907093
10MP0005330_cardiomyopathy2.66467310
11MP0003186_abnormal_redox_activity2.65166500
12MP0000751_myopathy2.61485014
13MP0004147_increased_porphyrin_level2.36983278
14MP0006035_abnormal_mitochondrial_morpho2.35711838
15MP0002139_abnormal_hepatobiliary_system2.24927571
16MP0004145_abnormal_muscle_electrophysio2.18534602
17MP0005085_abnormal_gallbladder_physiolo2.15536097
18MP0005360_urolithiasis2.14844008
19MP0009697_abnormal_copulation2.11309134
20MP0003693_abnormal_embryo_hatching2.06692039
21MP0008932_abnormal_embryonic_tissue2.04262497
22MP0005332_abnormal_amino_acid1.99257488
23MP0002938_white_spotting1.96953761
24MP0001764_abnormal_homeostasis1.96527107
25MP0002234_abnormal_pharynx_morphology1.94828606
26MP0003136_yellow_coat_color1.93150319
27MP0003011_delayed_dark_adaptation1.86601057
28MP0002972_abnormal_cardiac_muscle1.82893793
29MP0005365_abnormal_bile_salt1.82450594
30MP0002163_abnormal_gland_morphology1.80691570
31MP0006292_abnormal_olfactory_placode1.80596007
32MP0001905_abnormal_dopamine_level1.77901650
33MP0003195_calcinosis1.77412474
34MP0004043_abnormal_pH_regulation1.76753201
35MP0008875_abnormal_xenobiotic_pharmacok1.74751591
36MP0009379_abnormal_foot_pigmentation1.71369539
37MP0005319_abnormal_enzyme/_coenzyme1.66045359
38MP0002822_catalepsy1.63547329
39MP0001544_abnormal_cardiovascular_syste1.63461772
40MP0005385_cardiovascular_system_phenoty1.63461772
41MP0003123_paternal_imprinting1.61938369
42MP0002653_abnormal_ependyma_morphology1.58187117
43MP0000750_abnormal_muscle_regeneration1.57264450
44MP0003656_abnormal_erythrocyte_physiolo1.54447555
45MP0002269_muscular_atrophy1.53124306
46MP0003221_abnormal_cardiomyocyte_apopto1.51069919
47MP0004087_abnormal_muscle_fiber1.50633450
48MP0002736_abnormal_nociception_after1.50126039
49MP0008789_abnormal_olfactory_epithelium1.48498107
50MP0005266_abnormal_metabolism1.46794645
51MP0005620_abnormal_muscle_contractility1.42350352
52MP0003137_abnormal_impulse_conducting1.41184721
53MP0008775_abnormal_heart_ventricle1.40155864
54MP0005584_abnormal_enzyme/coenzyme_acti1.38462086
55MP0004957_abnormal_blastocyst_morpholog1.34194615
56MP0002876_abnormal_thyroid_physiology1.34126240
57MP0002106_abnormal_muscle_physiology1.33188564
58MP0009643_abnormal_urine_homeostasis1.33105540
59MP0001853_heart_inflammation1.30283123
60MP0003315_abnormal_perineum_morphology1.29835374
61MP0006072_abnormal_retinal_apoptosis1.29496425
62MP0001835_abnormal_antigen_presentation1.28162262
63MP0009840_abnormal_foam_cell1.25840397
64MP0000343_altered_response_to1.22368850
65MP0004142_abnormal_muscle_tone1.19098917
66MP0005636_abnormal_mineral_homeostasis1.18466154
67MP0010630_abnormal_cardiac_muscle1.17070810
68MP0006138_congestive_heart_failure1.15226020
69MP0005408_hypopigmentation1.14817908
70MP0005645_abnormal_hypothalamus_physiol1.13534488
71MP0004130_abnormal_muscle_cell1.12922393
72MP0004484_altered_response_of1.08904495
73MP0001346_abnormal_lacrimal_gland1.08098106
74MP0001986_abnormal_taste_sensitivity1.07626392
75MP0005670_abnormal_white_adipose1.07450269
76MP0002396_abnormal_hematopoietic_system1.07104861
77MP0005084_abnormal_gallbladder_morpholo1.06802170
78MP0000049_abnormal_middle_ear1.06643863
79MP0003828_pulmonary_edema1.05475443
80MP0001756_abnormal_urination1.04355189
81MP0009785_altered_susceptibility_to1.04267114
82MP0005376_homeostasis/metabolism_phenot1.03891293
83MP0009333_abnormal_splenocyte_physiolog1.02809200
84MP0002132_abnormal_respiratory_system1.01695962
85MP0010329_abnormal_lipoprotein_level0.98634927
86MP0002160_abnormal_reproductive_system0.98074935
87MP0005379_endocrine/exocrine_gland_phen0.97867662
88MP0005369_muscle_phenotype0.97157753
89MP0002127_abnormal_cardiovascular_syste0.96396415
90MP0008058_abnormal_DNA_repair0.95483053
91MP0000372_irregular_coat_pigmentation0.95276305
92MP0002102_abnormal_ear_morphology0.95151504
93MP0002332_abnormal_exercise_endurance0.95119114
94MP0003724_increased_susceptibility_to0.94554541
95MP0001661_extended_life_span0.94540070
96MP0002148_abnormal_hypersensitivity_rea0.94349591
97MP0009046_muscle_twitch0.94099071
98MP0005083_abnormal_biliary_tract0.93297927
99MP0006054_spinal_hemorrhage0.92598323
100MP0008469_abnormal_protein_level0.92455661
101MP0003786_premature_aging0.91315858
102MP0000759_abnormal_skeletal_muscle0.91161112
103MP0006276_abnormal_autonomic_nervous0.90985180
104MP0000358_abnormal_cell_content/0.90578341
105MP0000230_abnormal_systemic_arterial0.89342211
106MP0000747_muscle_weakness0.89092511
107MP0001968_abnormal_touch/_nociception0.88014707
108MP0001529_abnormal_vocalization0.86868528
109MP0003763_abnormal_thymus_physiology0.85973363
110MP0005394_taste/olfaction_phenotype0.85494348
111MP0005499_abnormal_olfactory_system0.85494348
112MP0005075_abnormal_melanosome_morpholog0.85337649
113MP0005646_abnormal_pituitary_gland0.84446725
114MP0010094_abnormal_chromosome_stability0.84394659
115MP0005671_abnormal_response_to0.83371927
116MP0002277_abnormal_respiratory_mucosa0.83234086
117MP0004085_abnormal_heartbeat0.81501405
118MP0002095_abnormal_skin_pigmentation0.81359918
119MP0003077_abnormal_cell_cycle0.81254907
120MP0001727_abnormal_embryo_implantation0.79188466
121MP0008007_abnormal_cellular_replicative0.79075587
122MP0003718_maternal_effect0.76718583
123MP0000678_abnormal_parathyroid_gland0.76165186
124MP0005058_abnormal_lysosome_morphology0.76090449
125MP0004233_abnormal_muscle_weight0.74640301
126MP0005165_increased_susceptibility_to0.74105340
127MP0008872_abnormal_physiological_respon0.73977347
128MP0003567_abnormal_fetal_cardiomyocyte0.73417593
129MP0000609_abnormal_liver_physiology0.73336736
130MP0001984_abnormal_olfaction0.73105149
131MP0005025_abnormal_response_to0.73033653
132MP0002138_abnormal_hepatobiliary_system0.71705795
133MP0002210_abnormal_sex_determination0.71688537
134MP0005389_reproductive_system_phenotype0.71539432
135MP0002118_abnormal_lipid_homeostasis0.70608269
136MP0005451_abnormal_body_composition0.69930432
137MP0000566_synostosis0.69874323
138MP0003111_abnormal_nucleus_morphology0.69002940
139MP0005253_abnormal_eye_physiology0.68874644
140MP0004133_heterotaxia0.68873435
141MP0004019_abnormal_vitamin_homeostasis0.67526560
142MP0005535_abnormal_body_temperature0.67351264
143MP0000598_abnormal_liver_morphology0.66699796
144MP0008995_early_reproductive_senescence0.66699021
145MP0001666_abnormal_nutrient_absorption0.66243339
146MP0005410_abnormal_fertilization0.66199810
147MP0000313_abnormal_cell_death0.65090474
148MP0001293_anophthalmia0.64940518
149MP0002249_abnormal_larynx_morphology0.62689843
150MP0001919_abnormal_reproductive_system0.62177141
151MP0000516_abnormal_urinary_system0.61728016
152MP0005367_renal/urinary_system_phenotyp0.61728016
153MP0005551_abnormal_eye_electrophysiolog0.60720274

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.62972775
2Abnormal mitochondria in muscle tissue (HP:0008316)5.58155361
3* Hepatic necrosis (HP:0002605)5.42342685
4* Hepatocellular necrosis (HP:0001404)5.11415586
5Acute encephalopathy (HP:0006846)5.07916911
6* Mitochondrial inheritance (HP:0001427)4.98851308
7* Increased CSF lactate (HP:0002490)4.73506528
8Progressive macrocephaly (HP:0004481)4.50459175
9Cerebral edema (HP:0002181)4.23636926
10Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.06859450
11Decreased activity of mitochondrial respiratory chain (HP:0008972)4.06859450
12* Lactic acidosis (HP:0003128)4.04181119
13* Increased serum lactate (HP:0002151)3.71135158
14Generalized aminoaciduria (HP:0002909)3.69849811
15Increased muscle lipid content (HP:0009058)3.68682716
16Exercise intolerance (HP:0003546)3.65207308
17Increased intramyocellular lipid droplets (HP:0012240)3.63903679
18Abnormality of fatty-acid metabolism (HP:0004359)3.61330344
19Abnormality of dicarboxylic acid metabolism (HP:0010995)3.56000770
20Dicarboxylic aciduria (HP:0003215)3.56000770
21* Respiratory failure (HP:0002878)3.45710055
22Lipid accumulation in hepatocytes (HP:0006561)3.42793539
23Increased serum pyruvate (HP:0003542)3.41205861
24Abnormality of glycolysis (HP:0004366)3.41205861
25Palpitations (HP:0001962)3.40823723
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.31691250
27Increased hepatocellular lipid droplets (HP:0006565)3.25378751
28Myoglobinuria (HP:0002913)3.21596576
29Abnormality of alanine metabolism (HP:0010916)3.14537498
30Hyperalaninemia (HP:0003348)3.14537498
31Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.14537498
32Lethargy (HP:0001254)3.10192199
33Hypoglycemic coma (HP:0001325)3.07324008
34Sudden death (HP:0001699)3.04671293
35Rhabdomyolysis (HP:0003201)3.03413187
36Proximal tubulopathy (HP:0000114)2.97208430
37Ventricular tachycardia (HP:0004756)2.90129096
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.87659159
39Nausea (HP:0002018)2.83003176
40Exercise-induced muscle cramps (HP:0003710)2.82698984
41Renal Fanconi syndrome (HP:0001994)2.78318251
42Reticulocytopenia (HP:0001896)2.74285411
43Ragged-red muscle fibers (HP:0003200)2.73552694
44Calf muscle hypertrophy (HP:0008981)2.73469154
45Ketoacidosis (HP:0001993)2.70482540
46Hyperglycinuria (HP:0003108)2.68733268
47Neoplasm of head and neck (HP:0012288)2.68357427
48Esophageal neoplasm (HP:0100751)2.68357427
49Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.66990410
50* CNS demyelination (HP:0007305)2.64774589
51Testicular atrophy (HP:0000029)2.64354428
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.63900697
53Glycosuria (HP:0003076)2.63536162
54Abnormality of urine glucose concentration (HP:0011016)2.63536162
55Lipoatrophy (HP:0100578)2.62127792
56Hyperammonemia (HP:0001987)2.59765306
57Neuroendocrine neoplasm (HP:0100634)2.59187599
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58003345
59Abnormal protein N-linked glycosylation (HP:0012347)2.58003345
60Abnormal protein glycosylation (HP:0012346)2.58003345
61Abnormal glycosylation (HP:0012345)2.58003345
623-Methylglutaconic aciduria (HP:0003535)2.56930066
63Pheochromocytoma (HP:0002666)2.50369387
64Optic disc pallor (HP:0000543)2.50298312
65Macrocytic anemia (HP:0001972)2.50067167
66Vomiting (HP:0002013)2.48192211
67Exercise-induced myalgia (HP:0003738)2.47097879
68Opisthotonus (HP:0002179)2.45534269
69Ketosis (HP:0001946)2.44993725
70Muscle hypertrophy of the lower extremities (HP:0008968)2.43833625
71Respiratory difficulties (HP:0002880)2.41632802
72Methylmalonic aciduria (HP:0012120)2.39019812
73Exertional dyspnea (HP:0002875)2.38952953
74Conjunctival hamartoma (HP:0100780)2.38704743
75Leukodystrophy (HP:0002415)2.38572420
76Dilated cardiomyopathy (HP:0001644)2.37881440
77Metabolic acidosis (HP:0001942)2.35119786
78Microvesicular hepatic steatosis (HP:0001414)2.32504617
79Microretrognathia (HP:0000308)2.31026892
80Neoplasm of the adrenal gland (HP:0100631)2.30923308
81Atrial fibrillation (HP:0005110)2.23412416
82Abnormality of serine family amino acid metabolism (HP:0010894)2.22953830
83Abnormality of glycine metabolism (HP:0010895)2.22953830
84Degeneration of anterior horn cells (HP:0002398)2.21347164
85Abnormality of the anterior horn cell (HP:0006802)2.21347164
86Type I transferrin isoform profile (HP:0003642)2.16578952
87Supraventricular tachycardia (HP:0004755)2.16201966
88Abnormal number of erythroid precursors (HP:0012131)2.14590366
89Multiple enchondromatosis (HP:0005701)2.14189779
90Pancytopenia (HP:0001876)2.13407575
91X-linked dominant inheritance (HP:0001423)2.13211161
92Abnormality of serum amino acid levels (HP:0003112)2.09153686
93Progressive microcephaly (HP:0000253)2.08159880
94Abnormality of cells of the erythroid lineage (HP:0012130)2.07692642
95Rough bone trabeculation (HP:0100670)2.07559438
96Renal cortical cysts (HP:0000803)2.07186701
97Supraventricular arrhythmia (HP:0005115)2.06988623
98Reduced antithrombin III activity (HP:0001976)2.06260043
99* Emotional lability (HP:0000712)2.06205116
100Progressive muscle weakness (HP:0003323)2.05757605
101Hypokinesia (HP:0002375)2.04489919
102Hyperglycinemia (HP:0002154)2.04423081
103Primary atrial arrhythmia (HP:0001692)2.03480596
104Gout (HP:0001997)2.01929161
105* Gliosis (HP:0002171)2.01343625
106Abnormality of the calf musculature (HP:0001430)1.96952251
107Abnormality of aromatic amino acid family metabolism (HP:0004338)1.95751426
108Myotonia (HP:0002486)1.95748774
109Cerebral hypomyelination (HP:0006808)1.94075738
110Blindness (HP:0000618)1.94022879
111Muscle fiber atrophy (HP:0100295)1.89718548
112Aplasia/hypoplasia of the uterus (HP:0008684)1.89637106
113Muscle fiber splitting (HP:0003555)1.89355724
114Aplastic anemia (HP:0001915)1.87812416
115Cerebral palsy (HP:0100021)1.86765430
116Abnormality of renal resorption (HP:0011038)1.85616258
117Abnormality of the left ventricular outflow tract (HP:0011103)1.81740485
118Subaortic stenosis (HP:0001682)1.81740485
119Unsteady gait (HP:0002317)1.81395858
120Nemaline bodies (HP:0003798)1.79709307
121Methylmalonic acidemia (HP:0002912)1.79346843
122Sclerocornea (HP:0000647)1.79175764
123Hyperphosphaturia (HP:0003109)1.76444115
124Tinnitus (HP:0000360)1.73983347
125Delayed CNS myelination (HP:0002188)1.70772801
126Myokymia (HP:0002411)1.70252441
127Oral leukoplakia (HP:0002745)1.69187678
128Poor suck (HP:0002033)1.68698222
129Myopathic facies (HP:0002058)1.68574658
130Sparse eyelashes (HP:0000653)1.68178422
131Type 2 muscle fiber atrophy (HP:0003554)1.67064824
132Muscle fiber inclusion bodies (HP:0100299)1.66216435
133Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.63949738
134Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.62899029
135Severe muscular hypotonia (HP:0006829)1.62610159
136Hypoplasia of the uterus (HP:0000013)1.60953349
137Pallor (HP:0000980)1.60542907
138Prolonged neonatal jaundice (HP:0006579)1.57231746
139Hypoplastic left heart (HP:0004383)1.55387305
140Abnormal trabecular bone morphology (HP:0100671)1.55164845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.99658912
2BCKDK4.53951498
3MYLK3.36424134
4NME23.18872701
5BUB12.96068030
6STK162.82369779
7EIF2AK12.61064957
8PDK32.58957478
9PDK42.58957478
10NEK12.53153859
11OBSCN2.32823928
12PIM22.30596906
13MAP3K122.22704501
14NME12.21794199
15ZAK1.93043418
16PINK11.90837038
17KDR1.88308982
18WEE11.72539180
19MUSK1.69577293
20IRAK31.65213584
21STK241.59273149
22CDK81.58638753
23PDK21.58224775
24CSNK1G31.57595952
25CDC71.55850075
26TTN1.54305441
27TSSK61.53623186
28LMTK21.53325472
29CCNB11.50099591
30EIF2AK31.49433933
31MAP3K111.49291511
32VRK11.48046479
33PBK1.39084353
34NUAK11.24186406
35ARAF1.20619610
36CSNK1A1L1.19620116
37FLT31.19494108
38CSNK1G11.16950036
39DYRK21.13935648
40NEK91.12076529
41CSNK1G21.11373611
42STK38L1.10079416
43MAP4K21.09082514
44TLK11.06327950
45BRAF1.05729990
46MAP2K31.03364179
47ILK1.01056875
48BRSK21.00866677
49ACVR1B1.00489841
50TAF10.99018890
51SRPK10.98073151
52EPHA20.97771840
53PHKG20.94294123
54PHKG10.94294123
55TIE10.93662112
56MAP4K10.93579666
57PIK3CA0.89703142
58MAP2K60.88774496
59TESK10.84014431
60RPS6KA50.83557011
61SMG10.82857875
62PLK40.80972066
63LRRK20.79664023
64MAPKAPK50.78952289
65BMPR1B0.78619144
66TEC0.78616495
67CHEK20.78607301
68STK40.77270739
69MAPKAPK30.76393319
70ABL20.75735085
71IRAK40.74378556
72GRK70.74335917
73DAPK30.74241091
74GRK50.73771284
75MST40.68936235
76PIK3CG0.66603805
77TBK10.65693338
78BRSK10.65386934
79TESK20.65111748
80ATR0.65024856
81CAMK2G0.64649895
82MAP3K30.64458594
83PLK30.63789974
84PRKG20.63731686
85PAK10.61336551
86ERN10.60442970
87KIT0.60015533
88CDK70.59702436
89SIK30.59156781
90TXK0.57541203
91TAOK20.57284758
92TGFBR10.56908060
93DAPK10.56900863
94ZAP700.56860914
95CSNK2A20.55180978
96AURKA0.53119540
97RPS6KA60.52049876
98BTK0.51717068
99RPS6KC10.51186338
100RPS6KL10.51186338
101LIMK10.49847366
102AKT20.49017210
103CSNK2A10.48594794
104AURKB0.48466286
105SYK0.47631277
106PKN20.47390204
107CDK190.46787759
108PAK40.46687379
109PRKD30.46397744
110TTK0.46225836
111MAPK120.44431659
112PLK10.44062548
113MAP2K70.38539141
114PIM10.38335417
115PRKCI0.37183235
116MAPK110.36411432
117IKBKB0.36336526
118PRKCD0.35951318
119WNK40.35432283
120EPHB20.34729325
121TYK20.34466365
122CAMK2D0.33040273
123BMPR20.32892321
124RPS6KB20.31738564
125WNK30.31517216
126MAPK40.31236700
127CSNK1A10.31147768
128SCYL20.30865378
129EIF2AK20.30780907
130MAP2K20.28951282
131ADRBK20.28437255
132CDK11A0.27795285
133CDK140.26708126
134MST1R0.25725325
135PKN10.25629719
136GRK10.25291868
137CAMK2B0.25088776
138CDK150.23704100
139CDK180.21043413
140MAP3K80.20818971
141ADRBK10.19181984
142RPS6KA40.18965466
143MINK10.18477352

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.47047043
2* Oxidative phosphorylation_Homo sapiens_hsa001904.02547251
3Parkinsons disease_Homo sapiens_hsa050123.73136863
4Proteasome_Homo sapiens_hsa030503.39742055
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.24628439
6Ribosome_Homo sapiens_hsa030102.63308438
7Huntingtons disease_Homo sapiens_hsa050162.48163941
8Propanoate metabolism_Homo sapiens_hsa006402.45422413
9Alzheimers disease_Homo sapiens_hsa050102.42060182
10* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.34261391
11Carbon metabolism_Homo sapiens_hsa012002.25192002
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22451706
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17415100
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08206647
15Pyruvate metabolism_Homo sapiens_hsa006202.02740201
16DNA replication_Homo sapiens_hsa030302.02610477
17Fatty acid degradation_Homo sapiens_hsa000711.94147403
18Cardiac muscle contraction_Homo sapiens_hsa042601.89740870
19RNA polymerase_Homo sapiens_hsa030201.86604473
20Mismatch repair_Homo sapiens_hsa034301.71729204
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59254277
22Pyrimidine metabolism_Homo sapiens_hsa002401.57739025
23Biosynthesis of amino acids_Homo sapiens_hsa012301.54022469
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53477155
25Protein export_Homo sapiens_hsa030601.45533147
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.45322997
27Fatty acid elongation_Homo sapiens_hsa000621.41114203
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35050437
29Peroxisome_Homo sapiens_hsa041461.33903866
30Fatty acid metabolism_Homo sapiens_hsa012121.31452240
31Sulfur relay system_Homo sapiens_hsa041221.31050893
32Pentose phosphate pathway_Homo sapiens_hsa000301.28583266
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28075773
34Butanoate metabolism_Homo sapiens_hsa006501.24839339
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22932449
36Folate biosynthesis_Homo sapiens_hsa007901.22748299
37Base excision repair_Homo sapiens_hsa034101.15955620
38beta-Alanine metabolism_Homo sapiens_hsa004101.14924196
39Fanconi anemia pathway_Homo sapiens_hsa034601.13158736
40Glutathione metabolism_Homo sapiens_hsa004801.11325555
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08960384
42Homologous recombination_Homo sapiens_hsa034401.08335878
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.08323547
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07366691
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.05539016
46Nucleotide excision repair_Homo sapiens_hsa034201.04441965
47Fructose and mannose metabolism_Homo sapiens_hsa000511.01058501
48Tryptophan metabolism_Homo sapiens_hsa003801.00293145
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00176766
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99132791
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96992983
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93595874
53Sulfur metabolism_Homo sapiens_hsa009200.93454306
54Galactose metabolism_Homo sapiens_hsa000520.92431334
55* Metabolic pathways_Homo sapiens_hsa011000.91344556
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89856119
57Arginine and proline metabolism_Homo sapiens_hsa003300.88683149
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87762625
59Phenylalanine metabolism_Homo sapiens_hsa003600.86521315
60Purine metabolism_Homo sapiens_hsa002300.86241397
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.85674083
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78993118
63One carbon pool by folate_Homo sapiens_hsa006700.78695156
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.77746128
65Spliceosome_Homo sapiens_hsa030400.76990244
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76137423
67Starch and sucrose metabolism_Homo sapiens_hsa005000.75555704
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75174463
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74811928
70Chemical carcinogenesis_Homo sapiens_hsa052040.66291277
71Collecting duct acid secretion_Homo sapiens_hsa049660.64055539
72Arginine biosynthesis_Homo sapiens_hsa002200.58469607
73Tyrosine metabolism_Homo sapiens_hsa003500.57940469
74Selenocompound metabolism_Homo sapiens_hsa004500.56712931
75RNA degradation_Homo sapiens_hsa030180.54540241
76Steroid biosynthesis_Homo sapiens_hsa001000.53931103
77PPAR signaling pathway_Homo sapiens_hsa033200.52905521
78Other glycan degradation_Homo sapiens_hsa005110.52135322
79Vitamin B6 metabolism_Homo sapiens_hsa007500.52122185
80RNA transport_Homo sapiens_hsa030130.48371182
81Vibrio cholerae infection_Homo sapiens_hsa051100.37333158
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35271819
83Legionellosis_Homo sapiens_hsa051340.35256436
84Histidine metabolism_Homo sapiens_hsa003400.35147897
85Synaptic vesicle cycle_Homo sapiens_hsa047210.35120401
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.34216366
87Systemic lupus erythematosus_Homo sapiens_hsa053220.34032747
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33795905
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31845487
90Arachidonic acid metabolism_Homo sapiens_hsa005900.29314454
91Basal transcription factors_Homo sapiens_hsa030220.28553224
92Regulation of autophagy_Homo sapiens_hsa041400.26744547
93Fat digestion and absorption_Homo sapiens_hsa049750.23895062
94Dilated cardiomyopathy_Homo sapiens_hsa054140.23414893
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22995892
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.22321393
97Retinol metabolism_Homo sapiens_hsa008300.21238127
98Phototransduction_Homo sapiens_hsa047440.21107393
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.16949253
100N-Glycan biosynthesis_Homo sapiens_hsa005100.16361825
101Primary immunodeficiency_Homo sapiens_hsa053400.14660520
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.14648658
103Alcoholism_Homo sapiens_hsa050340.14581942
104Cell cycle_Homo sapiens_hsa041100.14476053
105Epstein-Barr virus infection_Homo sapiens_hsa051690.13667847
106p53 signaling pathway_Homo sapiens_hsa041150.13263820
107Nitrogen metabolism_Homo sapiens_hsa009100.12860141
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12236764
109Glycerolipid metabolism_Homo sapiens_hsa005610.12179806
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.12039905
111Oocyte meiosis_Homo sapiens_hsa041140.09757124
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.09208269
113Vitamin digestion and absorption_Homo sapiens_hsa049770.09070205
114Non-homologous end-joining_Homo sapiens_hsa034500.08530123
115Basal cell carcinoma_Homo sapiens_hsa052170.05556925

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