NDUFV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)7.38996834
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.97508817
3NADH metabolic process (GO:0006734)5.91185208
4ATP synthesis coupled proton transport (GO:0015986)5.49185348
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.49185348
6regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.39380233
7sarcomere organization (GO:0045214)5.25099074
8* respiratory electron transport chain (GO:0022904)5.21672988
9* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.13499241
10lysine metabolic process (GO:0006553)5.12207043
11lysine catabolic process (GO:0006554)5.12207043
12regulation of acyl-CoA biosynthetic process (GO:0050812)5.11158606
13* electron transport chain (GO:0022900)5.08406038
14carnitine shuttle (GO:0006853)5.05479570
15succinate metabolic process (GO:0006105)4.93016454
16oxidative phosphorylation (GO:0006119)4.92152821
17aspartate family amino acid catabolic process (GO:0009068)4.84343787
18regulation of cofactor metabolic process (GO:0051193)4.81062624
19regulation of coenzyme metabolic process (GO:0051196)4.81062624
20Golgi transport vesicle coating (GO:0048200)4.80622273
21COPI coating of Golgi vesicle (GO:0048205)4.80622273
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.69695258
23cardiac myofibril assembly (GO:0055003)4.68601639
242-oxoglutarate metabolic process (GO:0006103)4.68431774
25fatty acid transmembrane transport (GO:1902001)4.65823092
26fatty acid beta-oxidation (GO:0006635)4.56565144
27oxaloacetate metabolic process (GO:0006107)4.54302973
28deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.51008055
29proline biosynthetic process (GO:0006561)4.47088513
30negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.33568021
31muscle filament sliding (GO:0030049)4.26897001
32actin-myosin filament sliding (GO:0033275)4.26897001
33branched-chain amino acid catabolic process (GO:0009083)4.26154491
34myofibril assembly (GO:0030239)4.18096414
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.16641052
36regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.15755536
37regulation of sequestering of triglyceride (GO:0010889)4.13849902
38regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.08732061
39cardiac muscle contraction (GO:0060048)4.07963771
40acetyl-CoA metabolic process (GO:0006084)4.05640501
41retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.05151392
42fatty acid catabolic process (GO:0009062)4.01930023
43negative regulation of potassium ion transmembrane transport (GO:1901380)4.00432289
44GDP-mannose metabolic process (GO:0019673)3.98912345
45peptidyl-arginine omega-N-methylation (GO:0035247)3.98281932
46cellular ketone body metabolic process (GO:0046950)3.98128456
47carnitine transmembrane transport (GO:1902603)3.95487138
48hexose biosynthetic process (GO:0019319)3.95027023
49monosaccharide biosynthetic process (GO:0046364)3.94959483
50tricarboxylic acid metabolic process (GO:0072350)3.92822009
51fatty acid oxidation (GO:0019395)3.91182383
52amino-acid betaine transport (GO:0015838)3.90675308
53carnitine transport (GO:0015879)3.90675308
54protein maturation by protein folding (GO:0022417)3.89916043
55lipid oxidation (GO:0034440)3.82858138
56short-chain fatty acid metabolic process (GO:0046459)3.82030885
57regulation of skeletal muscle contraction (GO:0014819)3.81782696
58glycolytic process (GO:0006096)3.80817478
59negative regulation of cell size (GO:0045792)3.79188670
60branched-chain amino acid metabolic process (GO:0009081)3.78331072
61regulation of fatty acid oxidation (GO:0046320)3.77014368
62regulation of sulfur metabolic process (GO:0042762)3.76225791
63ATP biosynthetic process (GO:0006754)3.72537413
64regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.65348111
65glyoxylate metabolic process (GO:0046487)3.60252435
66ventricular cardiac muscle cell action potential (GO:0086005)3.55060386
67monocarboxylic acid catabolic process (GO:0072329)3.52814559
68regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.52483934
69mitochondrial fusion (GO:0008053)3.49763441
70cardiac muscle cell development (GO:0055013)3.47466045
71ketone body metabolic process (GO:1902224)3.43693533
72actin-mediated cell contraction (GO:0070252)3.41856208
73bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39799239
74regulation of actin filament-based movement (GO:1903115)3.39600623
75nucleoside diphosphate biosynthetic process (GO:0009133)3.39438065
76regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.38355299
77inner mitochondrial membrane organization (GO:0007007)3.38066374
78biotin metabolic process (GO:0006768)3.35567499
79valine metabolic process (GO:0006573)3.34428246
80regulation of translational fidelity (GO:0006450)3.34367890
81pentose-phosphate shunt (GO:0006098)3.34205917
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.33197775
83L-phenylalanine metabolic process (GO:0006558)3.33197775
84carnitine metabolic process (GO:0009437)3.32619228
85heart process (GO:0003015)3.32485483
86heart contraction (GO:0060047)3.32485483
87plasma membrane repair (GO:0001778)3.30920071
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.29049705
89quaternary ammonium group transport (GO:0015697)3.25943667
90cardiac muscle hypertrophy (GO:0003300)3.25567871
91sarcoplasmic reticulum calcium ion transport (GO:0070296)3.24511138
92striated muscle contraction (GO:0006941)3.23086203
93proline metabolic process (GO:0006560)3.21631784
94quinone biosynthetic process (GO:1901663)3.19682100
95ubiquinone biosynthetic process (GO:0006744)3.19682100
96actomyosin structure organization (GO:0031032)3.19527240
97cardiac cell development (GO:0055006)3.18992681
98formation of translation preinitiation complex (GO:0001731)3.18903929
99cardiac muscle tissue morphogenesis (GO:0055008)3.18224237
100gluconeogenesis (GO:0006094)3.17550964
101protein retention in ER lumen (GO:0006621)3.16876549
102regulation of mitochondrial translation (GO:0070129)3.15767643
103amino-acid betaine metabolic process (GO:0006577)3.15391632
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.15030311
105L-phenylalanine catabolic process (GO:0006559)3.15030311
106regulation of relaxation of muscle (GO:1901077)3.14740921
107creatine metabolic process (GO:0006600)3.13272374
108regulation of cell communication by electrical coupling (GO:0010649)3.10966888
109striated muscle hypertrophy (GO:0014897)3.09022034
110nucleobase-containing small molecule interconversion (GO:0015949)3.08721408
111cell communication involved in cardiac conduction (GO:0086065)3.08468199
112positive regulation of fatty acid oxidation (GO:0046321)3.08023153
113maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06592318
114ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.05198438
115adult heart development (GO:0007512)3.03610961
116heart trabecula formation (GO:0060347)3.03496556
117peptidyl-arginine N-methylation (GO:0035246)3.03492338
118peptidyl-arginine methylation (GO:0018216)3.03492338
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.03143123
120regulation of oxidative phosphorylation (GO:0002082)3.01491841
121glucose catabolic process (GO:0006007)3.00846155
122purine nucleoside triphosphate biosynthetic process (GO:0009145)2.99940200
123histone arginine methylation (GO:0034969)2.99167070
124regulation of membrane repolarization (GO:0060306)2.99027289
125regulation of sarcomere organization (GO:0060297)2.97722513
126aerobic respiration (GO:0009060)2.97638756
127purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97518017
128DNA unwinding involved in DNA replication (GO:0006268)2.91874857
129fructose metabolic process (GO:0006000)2.90789309
130nuclear envelope reassembly (GO:0031468)2.88479999
131mitotic nuclear envelope reassembly (GO:0007084)2.88479999
132NADPH regeneration (GO:0006740)2.88243980
133iron-sulfur cluster assembly (GO:0016226)2.82944798
134metallo-sulfur cluster assembly (GO:0031163)2.82944798
135spliceosomal tri-snRNP complex assembly (GO:0000244)2.80567687
136pyruvate metabolic process (GO:0006090)2.80307733
137galactose catabolic process (GO:0019388)2.78156173
138deoxyribose phosphate biosynthetic process (GO:0046385)2.76951972
1392-deoxyribonucleotide biosynthetic process (GO:0009265)2.76951972
140DNA strand elongation involved in DNA replication (GO:0006271)2.73617139
1414-hydroxyproline metabolic process (GO:0019471)2.72894947
142negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.71778864
143skeletal muscle contraction (GO:0003009)2.71777869
144glutamine family amino acid biosynthetic process (GO:0009084)2.68725898
145nucleotide salvage (GO:0043173)2.68124653
146regulation of cellular respiration (GO:0043457)2.65731307
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62689549
148DNA strand elongation (GO:0022616)2.60904631
149glucose metabolic process (GO:0006006)2.60455060
150telomere maintenance via semi-conservative replication (GO:0032201)2.56854594
151negative regulation of necroptotic process (GO:0060546)2.56836634
152UV protection (GO:0009650)2.56082336
153regulation of superoxide anion generation (GO:0032928)2.53658727
154pentose metabolic process (GO:0019321)2.51621942
155glucose 6-phosphate metabolic process (GO:0051156)2.51387918
156heme biosynthetic process (GO:0006783)2.50063844
157folic acid metabolic process (GO:0046655)2.46329253
158endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.45323862
159protoporphyrinogen IX biosynthetic process (GO:0006782)2.43385678
160negative regulation of necrotic cell death (GO:0060547)2.43016471
161dicarboxylic acid biosynthetic process (GO:0043650)2.42448125
162regulation of mitochondrial membrane potential (GO:0051881)2.36173742
163apoptotic process involved in morphogenesis (GO:0060561)2.35040329
164protoporphyrinogen IX metabolic process (GO:0046501)2.34825725
165transcription from mitochondrial promoter (GO:0006390)2.34310976
166purine nucleotide salvage (GO:0032261)2.33161772
167barbed-end actin filament capping (GO:0051016)2.32958778
168pinocytosis (GO:0006907)2.32835174
169regulation of cholesterol biosynthetic process (GO:0045540)2.32393087
170nitrogen cycle metabolic process (GO:0071941)2.31387338
171porphyrin-containing compound biosynthetic process (GO:0006779)2.30167692
172hexose metabolic process (GO:0019318)2.29771997
173urea cycle (GO:0000050)2.27430190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.50332952
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.44846501
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse5.03280242
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.30577562
5RXR_22158963_ChIP-Seq_LIVER_Mouse3.99774099
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.75454926
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.06639575
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.05205789
9ZNF263_19887448_ChIP-Seq_K562_Human2.53135768
10E2F7_22180533_ChIP-Seq_HELA_Human2.41540979
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.38953788
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.37478442
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.19114798
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17860131
15EP300_21415370_ChIP-Seq_HL-1_Mouse2.13510330
16* VDR_21846776_ChIP-Seq_THP-1_Human2.12248636
17NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.05426567
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.05002767
19MYC_22102868_ChIP-Seq_BL_Human1.96670917
20CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93720994
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87961910
22CLOCK_20551151_ChIP-Seq_293T_Human1.86712853
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.85356912
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.85356912
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83653824
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81593920
27XRN2_22483619_ChIP-Seq_HELA_Human1.78185374
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77269266
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.73544965
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71714146
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70356131
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.69994151
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.67043922
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.65388342
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64396841
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.64105659
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.63337859
38* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59494804
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58718343
40PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56472311
41NELFA_20434984_ChIP-Seq_ESCs_Mouse1.48653981
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.47124328
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47116640
44MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.46831859
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45803605
46KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44546463
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42721497
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41949280
49GABP_19822575_ChIP-Seq_HepG2_Human1.40166651
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.40092340
51* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.39826831
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38585928
53EZH2_22144423_ChIP-Seq_EOC_Human1.37927683
54DCP1A_22483619_ChIP-Seq_HELA_Human1.37765747
55SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37565953
56* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.37074060
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.37051457
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.36629147
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35914077
60CIITA_25753668_ChIP-Seq_RAJI_Human1.35059249
61GATA4_21415370_ChIP-Seq_HL-1_Mouse1.34803058
62BP1_19119308_ChIP-ChIP_Hs578T_Human1.34432296
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33219419
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32263083
65MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31726163
66PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.30514343
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.30513418
68CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30411131
69ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.30280590
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26997499
71SMC4_20622854_ChIP-Seq_HELA_Human1.26838957
72SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.26384424
73* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24231123
74* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23887914
75* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22260866
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20325108
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17648019
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17431960
79CTCF_26484167_Chip-Seq_Bcells_Mouse1.16860971
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15639018
81NCOR1_26117541_ChIP-Seq_K562_Human1.15136277
82KDM2B_26808549_Chip-Seq_DND41_Human1.14489407
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14141495
84* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.14093623
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12237769
86* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11657064
87MAF_26560356_Chip-Seq_TH2_Human1.11584800
88YY1_22570637_ChIP-Seq_MALME-3M_Human1.10534596
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09789497
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08676644
91* FOXP1_21924763_ChIP-Seq_HESCs_Human1.07674187
92* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07092819
93EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06965315
94MAF_26560356_Chip-Seq_TH1_Human1.06935322
95* KDM5A_27292631_Chip-Seq_BREAST_Human1.06179872
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06137336
97SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.05994983
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05331732
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.05170941
100CTCF_27219007_Chip-Seq_Bcells_Human1.04658707
101GATA1_22383799_ChIP-Seq_G1ME_Mouse1.04185255
102RARB_24833708_ChIP-Seq_LIVER_Mouse1.03007146
103* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02442214
104YY1_21170310_ChIP-Seq_MESCs_Mouse1.01507398
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01476505
106P68_20966046_ChIP-Seq_HELA_Human0.97414593
107HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96906692
108* ETS1_20019798_ChIP-Seq_JURKAT_Human0.93753258
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93628834
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93158982
111BCL6_27268052_Chip-Seq_Bcells_Human0.92585075
112SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91849142
113TET1_21451524_ChIP-Seq_MESCs_Mouse0.91015555
114HTT_18923047_ChIP-ChIP_STHdh_Human0.87918301
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.87499433
116ERG_21242973_ChIP-ChIP_JURKAT_Human0.87113599
117RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86876719
118LXR_22292898_ChIP-Seq_THP-1_Human0.86474646
119RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85501339
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84925294
121OCT4_20526341_ChIP-Seq_ESCs_Human0.84631479
122REST_18959480_ChIP-ChIP_MESCs_Mouse0.84169815
123TAF2_19829295_ChIP-Seq_ESCs_Human0.83238753
124* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83121859
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82719797
126BCOR_27268052_Chip-Seq_Bcells_Human0.82233733
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80765655
128FOXH1_21741376_ChIP-Seq_ESCs_Human0.80375907
129GATA1_22025678_ChIP-Seq_K562_Human0.80026884
130* TP63_22573176_ChIP-Seq_HFKS_Human0.79298671
131CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78336217
132* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.77549471
133PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.77211318
134E2F1_20622854_ChIP-Seq_HELA_Human0.77183949
135CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.76365226
136CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73518429
137NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73460977
138ZNF274_21170338_ChIP-Seq_K562_Hela0.73140111
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.70964508
140ATF3_27146783_Chip-Seq_COLON_Human0.70533695
141* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.69827307
142HNF4A_19822575_ChIP-Seq_HepG2_Human0.69577619
143* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.69558085
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.69075872
145ERA_21632823_ChIP-Seq_H3396_Human0.68396271
146EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.68033810
147* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.67597537
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.66964125
149SOX2_21211035_ChIP-Seq_LN229_Human0.66578870
150ESR2_21235772_ChIP-Seq_MCF-7_Human0.65942008
151RACK7_27058665_Chip-Seq_MCF-7_Human0.65912571
152SA1_27219007_Chip-Seq_Bcells_Human0.65179172
153MYC_18358816_ChIP-ChIP_MESCs_Mouse0.64995440
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.64339980
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.63927635

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.02615058
2MP0003646_muscle_fatigue4.75860521
3MP0004084_abnormal_cardiac_muscle4.12028008
4MP0000751_myopathy4.05505511
5MP0004215_abnormal_myocardial_fiber3.71124308
6MP0004036_abnormal_muscle_relaxation3.46105016
7MP0000749_muscle_degeneration3.20209326
8MP0005058_abnormal_lysosome_morphology3.20016506
9MP0005330_cardiomyopathy3.16156240
10MP0006036_abnormal_mitochondrial_physio2.88789509
11MP0003806_abnormal_nucleotide_metabolis2.77654009
12MP0005360_urolithiasis2.72391170
13MP0002139_abnormal_hepatobiliary_system2.68797629
14MP0004130_abnormal_muscle_cell2.61408431
15MP0008260_abnormal_autophagy2.41442050
16MP0002972_abnormal_cardiac_muscle2.35159542
17MP0008775_abnormal_heart_ventricle2.35071868
18MP0005085_abnormal_gallbladder_physiolo2.32749891
19MP0004087_abnormal_muscle_fiber2.31845904
20MP0005620_abnormal_muscle_contractility2.20749260
21MP0003137_abnormal_impulse_conducting2.13118374
22MP0002269_muscular_atrophy2.08898652
23MP0005670_abnormal_white_adipose2.05737166
24MP0005365_abnormal_bile_salt2.01466263
25MP0004145_abnormal_muscle_electrophysio1.99815360
26MP0005385_cardiovascular_system_phenoty1.94045047
27MP0001544_abnormal_cardiovascular_syste1.94045047
28MP0004043_abnormal_pH_regulation1.91987103
29MP0000750_abnormal_muscle_regeneration1.90279005
30MP0005332_abnormal_amino_acid1.88365669
31MP0008875_abnormal_xenobiotic_pharmacok1.87425675
32MP0001661_extended_life_span1.87306096
33MP0006035_abnormal_mitochondrial_morpho1.86150952
34MP0000747_muscle_weakness1.85474298
35MP0002106_abnormal_muscle_physiology1.83085222
36MP0002822_catalepsy1.81892816
37MP0006138_congestive_heart_failure1.80090393
38MP0004484_altered_response_of1.80072951
39MP0005666_abnormal_adipose_tissue1.75547156
40MP0003221_abnormal_cardiomyocyte_apopto1.75278949
41MP0004085_abnormal_heartbeat1.68863400
42MP0003195_calcinosis1.67914082
43MP0003111_abnormal_nucleus_morphology1.63259233
44MP0010630_abnormal_cardiac_muscle1.62075187
45MP0000759_abnormal_skeletal_muscle1.56684916
46MP0002877_abnormal_melanocyte_morpholog1.55835139
47MP0004233_abnormal_muscle_weight1.51501650
48MP0005369_muscle_phenotype1.48690837
49MP0010234_abnormal_vibrissa_follicle1.48321027
50MP0000372_irregular_coat_pigmentation1.45493095
51MP0002332_abnormal_exercise_endurance1.42015056
52MP0010329_abnormal_lipoprotein_level1.40369866
53MP0000013_abnormal_adipose_tissue1.40153109
54MP0009278_abnormal_bone_marrow1.27294678
55MP0003693_abnormal_embryo_hatching1.26183077
56MP0004858_abnormal_nervous_system1.25362948
57MP0002118_abnormal_lipid_homeostasis1.24121362
58MP0000678_abnormal_parathyroid_gland1.22622437
59MP0005083_abnormal_biliary_tract1.21479164
60MP0002971_abnormal_brown_adipose1.17982197
61MP0005535_abnormal_body_temperature1.16909772
62MP0005266_abnormal_metabolism1.16803417
63MP0010094_abnormal_chromosome_stability1.16258260
64MP0005319_abnormal_enzyme/_coenzyme1.16254607
65MP0009840_abnormal_foam_cell1.16042956
66MP0005375_adipose_tissue_phenotype1.15285303
67MP0002127_abnormal_cardiovascular_syste1.14621554
68MP0005584_abnormal_enzyme/coenzyme_acti1.14368884
69MP0003077_abnormal_cell_cycle1.11773248
70MP0000733_abnormal_muscle_development1.08392539
71MP0000358_abnormal_cell_content/1.07980133
72MP0001730_embryonic_growth_arrest1.07968569
73MP0004185_abnormal_adipocyte_glucose1.05753501
74MP0003252_abnormal_bile_duct1.02916448
75MP0008007_abnormal_cellular_replicative1.01710750
76MP0005451_abnormal_body_composition0.99904869
77MP0009333_abnormal_splenocyte_physiolog0.98777359
78MP0000230_abnormal_systemic_arterial0.97896264
79MP0003950_abnormal_plasma_membrane0.97339981
80MP0004859_abnormal_synaptic_plasticity0.96298871
81MP0008932_abnormal_embryonic_tissue0.95416159
82MP0002078_abnormal_glucose_homeostasis0.94689628
83MP0004957_abnormal_blastocyst_morpholog0.92852443
84MP0001666_abnormal_nutrient_absorption0.91645739
85MP0009643_abnormal_urine_homeostasis0.91639382
86MP0003186_abnormal_redox_activity0.89340400
87MP0005165_increased_susceptibility_to0.87535284
88MP0004147_increased_porphyrin_level0.85448992
89MP0003191_abnormal_cellular_cholesterol0.85380662
90MP0000003_abnormal_adipose_tissue0.84062105
91MP0001764_abnormal_homeostasis0.83954407
92MP0000313_abnormal_cell_death0.82463948
93MP0003329_amyloid_beta_deposits0.82025712
94MP0001849_ear_inflammation0.81272360
95MP0003075_altered_response_to0.81261679
96MP0001853_heart_inflammation0.81056573
97MP0000681_abnormal_thyroid_gland0.80781133
98MP0005501_abnormal_skin_physiology0.80547109
99MP0002909_abnormal_adrenal_gland0.79624465
100MP0001529_abnormal_vocalization0.78679224
101MP0003828_pulmonary_edema0.77184935
102MP0003172_abnormal_lysosome_physiology0.75978393
103MP0003786_premature_aging0.74899969
104MP0002080_prenatal_lethality0.74776387
105MP0000604_amyloidosis0.73392609
106MP0001873_stomach_inflammation0.71789004
107MP0000609_abnormal_liver_physiology0.71351553
108MP0008874_decreased_physiological_sensi0.70837154
109MP0003763_abnormal_thymus_physiology0.69462188
110MP0005636_abnormal_mineral_homeostasis0.67735729
111MP0008569_lethality_at_weaning0.66171802
112MP0002019_abnormal_tumor_incidence0.66120517
113MP0002132_abnormal_respiratory_system0.65722789
114MP0001756_abnormal_urination0.65583906
115MP0000858_altered_metastatic_potential0.65377858
116MP0000350_abnormal_cell_proliferation0.65282292
117MP0005376_homeostasis/metabolism_phenot0.64506083
118MP0005166_decreased_susceptibility_to0.62854125
119MP0005386_behavior/neurological_phenoty0.61811929
120MP0004924_abnormal_behavior0.61811929
121MP0003656_abnormal_erythrocyte_physiolo0.61228389
122MP0000343_altered_response_to0.59063713
123MP0000266_abnormal_heart_morphology0.59007241
124MP0001765_abnormal_ion_homeostasis0.58855318
125MP0002108_abnormal_muscle_morphology0.58834376
126MP0005448_abnormal_energy_balance0.58375560
127MP0004019_abnormal_vitamin_homeostasis0.57864038
128MP0005334_abnormal_fat_pad0.54486927
129MP0005452_abnormal_adipose_tissue0.53905476
130MP0002272_abnormal_nervous_system0.52808877
131MP0002234_abnormal_pharynx_morphology0.51710628
132MP0004510_myositis0.51092493
133MP0002970_abnormal_white_adipose0.50882547
134MP0002876_abnormal_thyroid_physiology0.50254708
135MP0003705_abnormal_hypodermis_morpholog0.49629901
136MP0004142_abnormal_muscle_tone0.47644351
137MP0008872_abnormal_physiological_respon0.47118377
138MP0003953_abnormal_hormone_level0.45929323
139MP0010368_abnormal_lymphatic_system0.45330717
140MP0001727_abnormal_embryo_implantation0.40997200

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)5.26458315
2Myoglobinuria (HP:0002913)4.81490806
3Exercise-induced myalgia (HP:0003738)4.69081905
4Hepatic necrosis (HP:0002605)4.46542146
5Exercise-induced muscle cramps (HP:0003710)4.33793323
6Myopathic facies (HP:0002058)4.33669440
7* Abnormal mitochondria in muscle tissue (HP:0008316)4.27203164
8Ventricular tachycardia (HP:0004756)4.20830794
9Calf muscle hypertrophy (HP:0008981)4.18768401
10Centrally nucleated skeletal muscle fibers (HP:0003687)4.17855255
11* Acute necrotizing encephalopathy (HP:0006965)4.15373603
12Muscle fiber inclusion bodies (HP:0100299)4.11566323
13* Acute encephalopathy (HP:0006846)4.08000236
14Hepatocellular necrosis (HP:0001404)4.07393213
15Nemaline bodies (HP:0003798)4.03803195
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.00816841
17Rhabdomyolysis (HP:0003201)3.98993152
18Muscle hypertrophy of the lower extremities (HP:0008968)3.93437866
19Palpitations (HP:0001962)3.92867150
20* Cerebral edema (HP:0002181)3.80284890
21Abnormality of fatty-acid metabolism (HP:0004359)3.74856433
22Increased serum pyruvate (HP:0003542)3.74470967
23Abnormality of glycolysis (HP:0004366)3.74470967
24Muscle fiber splitting (HP:0003555)3.72011029
25Ketoacidosis (HP:0001993)3.62047193
26Dicarboxylic aciduria (HP:0003215)3.61005241
27Abnormality of dicarboxylic acid metabolism (HP:0010995)3.61005241
28* Mitochondrial inheritance (HP:0001427)3.59759271
29Distal lower limb muscle weakness (HP:0009053)3.56802610
30Atrial fibrillation (HP:0005110)3.52124862
31Hypoglycemic coma (HP:0001325)3.48712918
32* Increased CSF lactate (HP:0002490)3.47062837
33Ketosis (HP:0001946)3.42771846
34* Progressive macrocephaly (HP:0004481)3.40421484
35Lipoatrophy (HP:0100578)3.39770982
36Increased muscle lipid content (HP:0009058)3.38404812
37Hyperglycinuria (HP:0003108)3.35612660
38Abnormality of the calf musculature (HP:0001430)3.34791418
39Distal lower limb amyotrophy (HP:0008944)3.30243848
40Hyperammonemia (HP:0001987)3.28744503
41Pheochromocytoma (HP:0002666)3.27619798
42Progressive muscle weakness (HP:0003323)3.26352707
43Primary atrial arrhythmia (HP:0001692)3.26238444
44Hyporeflexia of lower limbs (HP:0002600)3.26014537
45* Lactic acidosis (HP:0003128)3.23490210
46Supraventricular tachycardia (HP:0004755)3.20021284
47Syncope (HP:0001279)3.19299641
48Supraventricular arrhythmia (HP:0005115)3.14541711
49Right ventricular cardiomyopathy (HP:0011663)3.08185322
50Microvesicular hepatic steatosis (HP:0001414)3.02495812
51Abnormality of glycine metabolism (HP:0010895)3.01297988
52Abnormality of serine family amino acid metabolism (HP:0010894)3.01297988
53Type 1 muscle fiber predominance (HP:0003803)2.99442162
54Dilated cardiomyopathy (HP:0001644)2.98295812
55Neuroendocrine neoplasm (HP:0100634)2.97772242
56Increased intramyocellular lipid droplets (HP:0012240)2.94999015
57Ragged-red muscle fibers (HP:0003200)2.88821884
58Conjunctival hamartoma (HP:0100780)2.84384044
59Bundle branch block (HP:0011710)2.82585342
60* Lethargy (HP:0001254)2.79486186
61EMG: myopathic abnormalities (HP:0003458)2.77248936
62* Respiratory failure (HP:0002878)2.76465404
63Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.76348907
64Generalized aminoaciduria (HP:0002909)2.75954390
65Prolonged QT interval (HP:0001657)2.71651380
66Ventricular arrhythmia (HP:0004308)2.64867139
67* Exercise intolerance (HP:0003546)2.64482313
68Asymmetric septal hypertrophy (HP:0001670)2.63001192
69Neck muscle weakness (HP:0000467)2.62711119
70Myotonia (HP:0002486)2.60748544
71Increased connective tissue (HP:0009025)2.59272364
72Muscle stiffness (HP:0003552)2.58548358
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.56652325
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.56652325
75Abnormality of skeletal muscle fiber size (HP:0012084)2.55155902
76Metabolic acidosis (HP:0001942)2.54832758
77Hyperalaninemia (HP:0003348)2.53450430
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53450430
79Abnormality of alanine metabolism (HP:0010916)2.53450430
80Gout (HP:0001997)2.51462819
81Achilles tendon contracture (HP:0001771)2.50215183
82Ventricular fibrillation (HP:0001663)2.48093818
83Increased serum lactate (HP:0002151)2.47569141
84Heart block (HP:0012722)2.47423841
85Hyperglycinemia (HP:0002154)2.46045249
86Reticulocytosis (HP:0001923)2.45642115
87Difficulty running (HP:0009046)2.45459791
88Subaortic stenosis (HP:0001682)2.44471776
89Abnormality of the left ventricular outflow tract (HP:0011103)2.44471776
90Difficulty climbing stairs (HP:0003551)2.40437931
91Lipid accumulation in hepatocytes (HP:0006561)2.40274634
92Atrioventricular block (HP:0001678)2.39120158
93Stridor (HP:0010307)2.35641548
94Truncus arteriosus (HP:0001660)2.35575844
95CNS demyelination (HP:0007305)2.33724496
96Upper limb amyotrophy (HP:0009129)2.33438697
97Distal upper limb amyotrophy (HP:0007149)2.33438697
98Cholelithiasis (HP:0001081)2.32961548
99Abnormal atrioventricular conduction (HP:0005150)2.31180278
100* Vomiting (HP:0002013)2.30395774
101Seborrheic dermatitis (HP:0001051)2.26048054
102Abnormality of the Achilles tendon (HP:0005109)2.25798785
103Foot dorsiflexor weakness (HP:0009027)2.25623130
104Lower limb amyotrophy (HP:0007210)2.25601129
105Hyperthyroidism (HP:0000836)2.22932708
106Hypertensive crisis (HP:0100735)2.21409034
107Abnormality of the foot musculature (HP:0001436)2.20152827
108Cerebral palsy (HP:0100021)2.20124642
109Increased variability in muscle fiber diameter (HP:0003557)2.19936970
110Neoplasm of the adrenal gland (HP:0100631)2.18879579
111Proximal tubulopathy (HP:0000114)2.17985766
112Methylmalonic aciduria (HP:0012120)2.15879313
113Vertebral compression fractures (HP:0002953)2.14172093
114Neoplasm of head and neck (HP:0012288)2.14111802
115Esophageal neoplasm (HP:0100751)2.14111802
116Abnormal gallbladder morphology (HP:0012437)2.12213476
117Athetosis (HP:0002305)2.12133942
118Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11630532
119Rimmed vacuoles (HP:0003805)2.10944067
120Testicular atrophy (HP:0000029)2.08558451
121Bulbar palsy (HP:0001283)2.08492358
122Cholecystitis (HP:0001082)2.07375425
123Abnormal gallbladder physiology (HP:0012438)2.07375425
124Nausea (HP:0002018)2.07086772
125Mildly elevated creatine phosphokinase (HP:0008180)2.06375535
126Abnormality of the tricuspid valve (HP:0001702)2.05651579
127Abnormality of serum amino acid levels (HP:0003112)2.03706136
128Hyperacusis (HP:0010780)2.01699946
129Emotional lability (HP:0000712)2.01670381
130Hypoalphalipoproteinemia (HP:0003233)2.01375888
131* Leukodystrophy (HP:0002415)2.00620978
132Left ventricular hypertrophy (HP:0001712)1.98813442
133Xanthomatosis (HP:0000991)1.98190791
134Abnormal EKG (HP:0003115)1.97654891
135* Optic disc pallor (HP:0000543)1.97442574
136Glycosuria (HP:0003076)1.96800922
137EMG: neuropathic changes (HP:0003445)1.96166643
138Hypokinesia (HP:0002375)1.93114565
139Abnormality of the gallbladder (HP:0005264)1.92751369
140Round ear (HP:0100830)1.90956295
141Ulnar deviation of the wrist (HP:0003049)1.90530032
142Progressive external ophthalmoplegia (HP:0000590)1.89703840
143Diaphragmatic weakness (HP:0009113)1.87322238
144Abnormality of reticulocytes (HP:0004312)1.87016131
145Limb-girdle muscle atrophy (HP:0003797)1.86331168
146Insomnia (HP:0100785)1.81178844
147Calcaneovalgus deformity (HP:0001848)1.81028511
148Fatigue (HP:0012378)1.80892172
149Ankle clonus (HP:0011448)1.79769012
150Hand muscle atrophy (HP:0009130)1.79572346
151Trismus (HP:0000211)1.79132386
152Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77483325
153Spastic paraparesis (HP:0002313)1.74594952
154Abnormality of glycolipid metabolism (HP:0010969)1.73708697
155Abnormality of liposaccharide metabolism (HP:0010968)1.73708697
156Abnormality of glycosphingolipid metabolism (HP:0004343)1.73708697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.30013373
2PDK34.69059906
3PDK44.69059906
4TTN3.90173192
5OBSCN3.77353586
6LMTK23.40241376
7MYLK3.31360779
8NEK13.16609432
9PHKG13.13575782
10PHKG23.13575782
11TESK23.08725844
12PDK22.78603476
13SMG12.71024789
14TESK12.65806064
15TRIB32.51856030
16EEF2K2.32987177
17PINK12.23946613
18PKN22.17515610
19SCYL22.09151876
20VRK22.06397335
21IRAK32.02211809
22ICK1.94473606
23ERN11.93682392
24PIK3CA1.90962240
25WNK41.89222414
26PRPF4B1.88297905
27NME11.70069233
28PIM21.60838531
29EPHA21.49852255
30TIE11.32177195
31CAMK2D1.25872637
32MAP2K41.25788651
33STK241.22499156
34MUSK1.18864718
35STK38L1.15633409
36PAK31.12413705
37ILK1.11271001
38DAPK31.09885967
39TBK11.06953796
40MAP3K41.06699762
41PRKD31.05763805
42DMPK0.95864005
43OXSR10.94323488
44STK390.93695993
45RPS6KB20.91801156
46MAP2K30.90734610
47MAPK120.87382819
48TAOK20.86358000
49GRK70.86156702
50CAMK2G0.83074238
51PAK40.82265809
52PBK0.81595174
53PTK2B0.81233311
54AURKA0.80361825
55MAP3K80.78528245
56MAPKAPK30.77553824
57PRKD10.77442376
58EIF2AK10.75717808
59CAMK2A0.72106665
60RIPK40.71991612
61RAF10.71309935
62TNK20.70031716
63LIMK10.69788051
64CDK190.68993644
65BRSK10.68752675
66PRKAA10.68515333
67WNK30.67459590
68ARAF0.67183825
69ROCK10.67077255
70LRRK20.67031281
71MST1R0.66994531
72PDPK10.66288038
73SIK20.65826507
74SGK4940.65514208
75SGK2230.65514208
76MAP3K70.65277351
77MAP4K10.63191153
78MAP2K10.62003657
79CDC42BPA0.59847157
80KDR0.58847618
81NME20.57906745
82MAP2K20.55662839
83PAK10.55330282
84DAPK20.55120313
85PRKAA20.54651959
86BRAF0.54503992
87CDK70.54450515
88MAP3K60.53376773
89MAP3K30.53067406
90MAP3K110.52822376
91CDK11A0.52354761
92EPHA40.52289618
93ROCK20.52285005
94PRKACG0.52073599
95FLT30.52049235
96CAMK2B0.50950932
97INSRR0.50948366
98PRKCI0.50776848
99FGFR40.50257315
100CDK40.50245035
101PRKACA0.49512607
102PRKACB0.48747269
103BMX0.48624685
104MARK20.48010184
105SIK10.47417448
106STK160.46184074
107MAP3K50.45810664
108CAMK40.45188288
109MTOR0.45144688
110CDK150.45085472
111PKN10.44906679
112MAP3K120.44895148
113MAP2K60.44808439
114FER0.44495548
115MAP3K130.43399199
116CAMKK10.42275376
117MAP3K10.42065305
118BUB10.42022602
119PDK10.41781387
120AURKB0.41705752
121TTK0.40632842
122STK380.40559452
123MINK10.40481748
124CCNB10.40300514
125PRKCE0.40241569
126PTK60.38863637
127CDK140.38240041
128CDK180.38169028
129NTRK10.37136443
130RIPK10.36426309
131KSR20.36119658
132EPHB10.35550866
133ATR0.35068300
134PRKD20.33859748
135AKT20.33794974
136DAPK10.32988797
137UHMK10.32341848
138MET0.32153842
139ABL20.31376863
140CSNK1G30.31354063
141TSSK60.29733779
142PIK3CG0.29409094
143GRK50.28331741
144CAMK10.27492983
145MAPK110.27161741
146WNK10.27016006
147PRKCG0.26960688
148CASK0.25182365
149PAK60.24758233
150ZAK0.24714092
151LATS20.23862271
152SGK30.21192645
153RPS6KC10.20443327
154RPS6KL10.20443327
155ADRBK10.20314756

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.19587227
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.12208860
3Propanoate metabolism_Homo sapiens_hsa006403.54316089
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.20845476
5* Oxidative phosphorylation_Homo sapiens_hsa001903.18628543
6Fatty acid degradation_Homo sapiens_hsa000713.01836494
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97681640
8Parkinsons disease_Homo sapiens_hsa050122.94109734
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74574557
10DNA replication_Homo sapiens_hsa030302.60724904
11Carbon metabolism_Homo sapiens_hsa012002.60492784
12Pyruvate metabolism_Homo sapiens_hsa006202.56492961
13Cardiac muscle contraction_Homo sapiens_hsa042602.55338681
14Fatty acid metabolism_Homo sapiens_hsa012122.48665758
15Other glycan degradation_Homo sapiens_hsa005112.47375291
16Butanoate metabolism_Homo sapiens_hsa006502.35266182
17Base excision repair_Homo sapiens_hsa034102.18608454
18Alzheimers disease_Homo sapiens_hsa050102.08472324
19Fatty acid elongation_Homo sapiens_hsa000621.99497554
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99207290
21* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85914887
22Huntingtons disease_Homo sapiens_hsa050161.83062721
23Biosynthesis of amino acids_Homo sapiens_hsa012301.68927507
24Arginine biosynthesis_Homo sapiens_hsa002201.65043670
25Tryptophan metabolism_Homo sapiens_hsa003801.64757407
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60317955
27PPAR signaling pathway_Homo sapiens_hsa033201.55103009
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.53962869
29beta-Alanine metabolism_Homo sapiens_hsa004101.45326510
30Peroxisome_Homo sapiens_hsa041461.41710901
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.40135712
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26609562
33Ribosome_Homo sapiens_hsa030101.25818450
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22934200
35Dilated cardiomyopathy_Homo sapiens_hsa054141.22086107
36Sulfur metabolism_Homo sapiens_hsa009201.19654821
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16023019
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.15059227
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13782476
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12881640
41Phenylalanine metabolism_Homo sapiens_hsa003601.12225382
42Nitrogen metabolism_Homo sapiens_hsa009101.05041883
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03340492
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01759324
45Pyrimidine metabolism_Homo sapiens_hsa002401.01228644
46Starch and sucrose metabolism_Homo sapiens_hsa005000.97699757
47Mismatch repair_Homo sapiens_hsa034300.97528314
48Arginine and proline metabolism_Homo sapiens_hsa003300.95090671
49Spliceosome_Homo sapiens_hsa030400.82521689
50Tyrosine metabolism_Homo sapiens_hsa003500.82245521
51Fructose and mannose metabolism_Homo sapiens_hsa000510.79968309
52Sulfur relay system_Homo sapiens_hsa041220.79649925
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77795368
54Fat digestion and absorption_Homo sapiens_hsa049750.77781873
55Nucleotide excision repair_Homo sapiens_hsa034200.76164464
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75737069
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73974055
58N-Glycan biosynthesis_Homo sapiens_hsa005100.72602247
59Prion diseases_Homo sapiens_hsa050200.72261714
60Glycerolipid metabolism_Homo sapiens_hsa005610.71961969
61Bile secretion_Homo sapiens_hsa049760.71830843
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66028337
63* Metabolic pathways_Homo sapiens_hsa011000.65919401
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65911275
65Glucagon signaling pathway_Homo sapiens_hsa049220.65239506
66One carbon pool by folate_Homo sapiens_hsa006700.64605258
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63737811
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63594860
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61843379
70Fatty acid biosynthesis_Homo sapiens_hsa000610.61726745
71Collecting duct acid secretion_Homo sapiens_hsa049660.61348010
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.59963750
73Pentose phosphate pathway_Homo sapiens_hsa000300.59937870
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59352011
75Glutathione metabolism_Homo sapiens_hsa004800.58659568
76Proteasome_Homo sapiens_hsa030500.58244123
77Galactose metabolism_Homo sapiens_hsa000520.57501227
78Chemical carcinogenesis_Homo sapiens_hsa052040.57250794
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.52311144
80Histidine metabolism_Homo sapiens_hsa003400.49492112
81Purine metabolism_Homo sapiens_hsa002300.49226826
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.48822227
83Selenocompound metabolism_Homo sapiens_hsa004500.46247247
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45021376
85Acute myeloid leukemia_Homo sapiens_hsa052210.44299974
86Folate biosynthesis_Homo sapiens_hsa007900.42632035
87VEGF signaling pathway_Homo sapiens_hsa043700.41921034
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.41671011
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37534405
90Bladder cancer_Homo sapiens_hsa052190.37326778
91Insulin resistance_Homo sapiens_hsa049310.37015702
92Lysosome_Homo sapiens_hsa041420.37008135
93Shigellosis_Homo sapiens_hsa051310.36902161
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36815275
95Insulin signaling pathway_Homo sapiens_hsa049100.36163459
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34879501
97Lysine degradation_Homo sapiens_hsa003100.34422340
98Viral myocarditis_Homo sapiens_hsa054160.34232016
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34139614
100Systemic lupus erythematosus_Homo sapiens_hsa053220.33919449
101AMPK signaling pathway_Homo sapiens_hsa041520.33243126
102Vitamin B6 metabolism_Homo sapiens_hsa007500.32468723
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32221226
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31667217
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31534392
106RNA transport_Homo sapiens_hsa030130.31269544
107Synaptic vesicle cycle_Homo sapiens_hsa047210.28119217
108Complement and coagulation cascades_Homo sapiens_hsa046100.27878894
109Epstein-Barr virus infection_Homo sapiens_hsa051690.26392977
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.23570011
111Non-small cell lung cancer_Homo sapiens_hsa052230.23416325
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.22928700
113Calcium signaling pathway_Homo sapiens_hsa040200.22702370
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22451147
115Primary immunodeficiency_Homo sapiens_hsa053400.21759785
116Retinol metabolism_Homo sapiens_hsa008300.21220347
117Viral carcinogenesis_Homo sapiens_hsa052030.20798882
118Vibrio cholerae infection_Homo sapiens_hsa051100.17713253
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.17120545
120Insulin secretion_Homo sapiens_hsa049110.17075582
121Alcoholism_Homo sapiens_hsa050340.16889490
122Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16811724
123Gastric acid secretion_Homo sapiens_hsa049710.16315587
124ABC transporters_Homo sapiens_hsa020100.15784255
125Salmonella infection_Homo sapiens_hsa051320.14955243
126Apoptosis_Homo sapiens_hsa042100.14702179
127Caffeine metabolism_Homo sapiens_hsa002320.12953884
128Oocyte meiosis_Homo sapiens_hsa041140.12427582
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.11673219
130Renin secretion_Homo sapiens_hsa049240.10854213
131GABAergic synapse_Homo sapiens_hsa047270.10590072
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.09077119
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.08417279
134Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.04718958
135HIF-1 signaling pathway_Homo sapiens_hsa040660.04556873

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »