

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.97309632 |
| 2 | proteasome assembly (GO:0043248) | 5.22687130 |
| 3 | cytidine deamination (GO:0009972) | 4.64596711 |
| 4 | cytidine metabolic process (GO:0046087) | 4.64596711 |
| 5 | cytidine catabolic process (GO:0006216) | 4.64596711 |
| 6 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.26895831 |
| 7 | respiratory chain complex IV assembly (GO:0008535) | 4.17801184 |
| 8 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.09566056 |
| 9 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.94355962 |
| 10 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.91924040 |
| 11 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.91333049 |
| 12 | DNA double-strand break processing (GO:0000729) | 3.88245936 |
| 13 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.85537221 |
| 14 | protein complex biogenesis (GO:0070271) | 3.85267678 |
| 15 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 3.77931068 |
| 16 | cullin deneddylation (GO:0010388) | 3.76296743 |
| 17 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.72000345 |
| 18 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.70659261 |
| 19 | cytochrome complex assembly (GO:0017004) | 3.68380823 |
| 20 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.62537679 |
| 21 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.61143260 |
| 22 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.61143260 |
| 23 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.61143260 |
| 24 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.59128688 |
| 25 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.59128688 |
| 26 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.59095991 |
| 27 | protein deneddylation (GO:0000338) | 3.58017707 |
| 28 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.56445102 |
| 29 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.53166800 |
| 30 | ATP synthesis coupled proton transport (GO:0015986) | 3.53166800 |
| 31 | respiratory electron transport chain (GO:0022904) | 3.51005105 |
| 32 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.50595215 |
| 33 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.50595215 |
| 34 | electron transport chain (GO:0022900) | 3.48968428 |
| 35 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.46013807 |
| 36 | protein neddylation (GO:0045116) | 3.45884292 |
| 37 | mannosylation (GO:0097502) | 3.43216081 |
| 38 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.39624831 |
| 39 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.39624831 |
| 40 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.39173601 |
| 41 | amino acid salvage (GO:0043102) | 3.39140813 |
| 42 | L-methionine salvage (GO:0071267) | 3.39140813 |
| 43 | L-methionine biosynthetic process (GO:0071265) | 3.39140813 |
| 44 | NADH dehydrogenase complex assembly (GO:0010257) | 3.35168684 |
| 45 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.35168684 |
| 46 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.35168684 |
| 47 | negative regulation of ligase activity (GO:0051352) | 3.32554236 |
| 48 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.32554236 |
| 49 | rRNA modification (GO:0000154) | 3.30811191 |
| 50 | branched-chain amino acid catabolic process (GO:0009083) | 3.25626383 |
| 51 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.24323577 |
| 52 | termination of RNA polymerase III transcription (GO:0006386) | 3.22449846 |
| 53 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.22449846 |
| 54 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.20191832 |
| 55 | platelet dense granule organization (GO:0060155) | 3.16159616 |
| 56 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.15389723 |
| 57 | response to pheromone (GO:0019236) | 3.10784229 |
| 58 | maturation of 5.8S rRNA (GO:0000460) | 3.06971000 |
| 59 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.04465264 |
| 60 | signal peptide processing (GO:0006465) | 3.04236980 |
| 61 | positive regulation of ligase activity (GO:0051351) | 3.04222751 |
| 62 | preassembly of GPI anchor in ER membrane (GO:0016254) | 3.03386766 |
| 63 | protein-cofactor linkage (GO:0018065) | 2.90577993 |
| 64 | regulation of cellular amine metabolic process (GO:0033238) | 2.90083977 |
| 65 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.87050272 |
| 66 | lactate metabolic process (GO:0006089) | 2.84665252 |
| 67 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 2.84225202 |
| 68 | pseudouridine synthesis (GO:0001522) | 2.84103940 |
| 69 | iron-sulfur cluster assembly (GO:0016226) | 2.83628122 |
| 70 | metallo-sulfur cluster assembly (GO:0031163) | 2.83628122 |
| 71 | peptidyl-histidine modification (GO:0018202) | 2.83434264 |
| 72 | rRNA methylation (GO:0031167) | 2.83325850 |
| 73 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.83257107 |
| 74 | protein targeting to mitochondrion (GO:0006626) | 2.81734302 |
| 75 | ubiquinone biosynthetic process (GO:0006744) | 2.80889192 |
| 76 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.78089531 |
| 77 | regulation of mitochondrial translation (GO:0070129) | 2.76020054 |
| 78 | GPI anchor metabolic process (GO:0006505) | 2.72846548 |
| 79 | positive regulation of cell cycle arrest (GO:0071158) | 2.72237779 |
| 80 | oxidative phosphorylation (GO:0006119) | 2.71798072 |
| 81 | protein localization to mitochondrion (GO:0070585) | 2.71498108 |
| 82 | chaperone-mediated protein transport (GO:0072321) | 2.70547831 |
| 83 | ubiquinone metabolic process (GO:0006743) | 2.67425633 |
| 84 | GPI anchor biosynthetic process (GO:0006506) | 2.65958992 |
| 85 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.64660369 |
| 86 | establishment of protein localization to mitochondrion (GO:0072655) | 2.63748451 |
| 87 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 2.63568649 |
| 88 | isotype switching (GO:0045190) | 2.63568649 |
| 89 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 2.63568649 |
| 90 | cellular ketone body metabolic process (GO:0046950) | 2.63554590 |
| 91 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 2.63496723 |
| 92 | negative regulation of telomere maintenance (GO:0032205) | 2.63129505 |
| 93 | branched-chain amino acid metabolic process (GO:0009081) | 2.60773872 |
| 94 | C-terminal protein lipidation (GO:0006501) | 2.60663539 |
| 95 | ribosome assembly (GO:0042255) | 2.60608905 |
| 96 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.60551164 |
| 97 | DNA damage response, detection of DNA damage (GO:0042769) | 2.60154448 |
| 98 | tRNA processing (GO:0008033) | 2.57621499 |
| 99 | regulation of ligase activity (GO:0051340) | 2.57533755 |
| 100 | hydrogen ion transmembrane transport (GO:1902600) | 2.56071302 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.81352997 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.09324228 |
| 3 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.85698652 |
| 4 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.74485306 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.49423173 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.07024329 |
| 7 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.01518831 |
| 8 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.81979094 |
| 9 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.66922166 |
| 10 | VDR_22108803_ChIP-Seq_LS180_Human | 2.59380745 |
| 11 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.55724743 |
| 12 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.54704643 |
| 13 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.44869711 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.44296037 |
| 15 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.30320483 |
| 16 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.28255902 |
| 17 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.27575082 |
| 18 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.17443321 |
| 19 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.17165159 |
| 20 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.16561677 |
| 21 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.12926931 |
| 22 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.07895910 |
| 23 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.93524077 |
| 24 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.91534481 |
| 25 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.86178476 |
| 26 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.76227710 |
| 27 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.73347492 |
| 28 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.69494275 |
| 29 | EWS_26573619_Chip-Seq_HEK293_Human | 1.67540535 |
| 30 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.63074596 |
| 31 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.62989324 |
| 32 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.62133181 |
| 33 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.55115791 |
| 34 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.53680079 |
| 35 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.53361840 |
| 36 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.52906328 |
| 37 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.49651383 |
| 38 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.43391263 |
| 39 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.42953052 |
| 40 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.41819350 |
| 41 | P300_19829295_ChIP-Seq_ESCs_Human | 1.40251273 |
| 42 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.37660652 |
| 43 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.34193682 |
| 44 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.30945641 |
| 45 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.30103629 |
| 46 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.29613274 |
| 47 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.29446840 |
| 48 | FUS_26573619_Chip-Seq_HEK293_Human | 1.28537908 |
| 49 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.25743526 |
| 50 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.25710118 |
| 51 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.23816613 |
| 52 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.22358394 |
| 53 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.22358394 |
| 54 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.20250603 |
| 55 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.20250603 |
| 56 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.19072602 |
| 57 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.18845598 |
| 58 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.17960785 |
| 59 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.17370683 |
| 60 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.17317628 |
| 61 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.16747467 |
| 62 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.16690809 |
| 63 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.15342394 |
| 64 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.14842792 |
| 65 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.14224724 |
| 66 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.13473832 |
| 67 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.11991086 |
| 68 | AR_20517297_ChIP-Seq_VCAP_Human | 1.11218427 |
| 69 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.10243184 |
| 70 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.08309170 |
| 71 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.07011359 |
| 72 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.06289376 |
| 73 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.06289376 |
| 74 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.05774684 |
| 75 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.05417881 |
| 76 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.04538699 |
| 77 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.03845691 |
| 78 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.03293604 |
| 79 | FOXA1_21572438_ChIP-Seq_LNCaP_Human | 1.02413720 |
| 80 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02072815 |
| 81 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.01631945 |
| 82 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.01366261 |
| 83 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.01071112 |
| 84 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.00134918 |
| 85 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.99725504 |
| 86 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 0.97382282 |
| 87 | GATA3_26560356_Chip-Seq_TH2_Human | 0.97235045 |
| 88 | NCOR_22424771_ChIP-Seq_293T_Human | 0.95552999 |
| 89 | TTF2_22483619_ChIP-Seq_HELA_Human | 0.94942813 |
| 90 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.93395130 |
| 91 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.92774319 |
| 92 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.89304459 |
| 93 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.88237651 |
| 94 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.87003818 |
| 95 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.86932770 |
| 96 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 0.86905253 |
| 97 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.86279312 |
| 98 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.86035839 |
| 99 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.85796118 |
| 100 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.85155663 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0002102_abnormal_ear_morphology | 3.26294050 |
| 2 | MP0002837_dystrophic_cardiac_calcinosis | 3.14842384 |
| 3 | MP0003806_abnormal_nucleotide_metabolis | 2.79894580 |
| 4 | MP0008058_abnormal_DNA_repair | 2.75518542 |
| 5 | MP0000372_irregular_coat_pigmentation | 2.72271671 |
| 6 | MP0006036_abnormal_mitochondrial_physio | 2.72223486 |
| 7 | MP0003195_calcinosis | 2.54978744 |
| 8 | MP0005645_abnormal_hypothalamus_physiol | 2.47977636 |
| 9 | MP0008877_abnormal_DNA_methylation | 2.34032233 |
| 10 | MP0005671_abnormal_response_to | 2.31766545 |
| 11 | MP0006072_abnormal_retinal_apoptosis | 2.24961362 |
| 12 | MP0003786_premature_aging | 2.13570337 |
| 13 | MP0003646_muscle_fatigue | 2.12519184 |
| 14 | MP0006035_abnormal_mitochondrial_morpho | 1.93590422 |
| 15 | MP0001529_abnormal_vocalization | 1.91004631 |
| 16 | MP0009697_abnormal_copulation | 1.90521690 |
| 17 | MP0001984_abnormal_olfaction | 1.87439621 |
| 18 | MP0008875_abnormal_xenobiotic_pharmacok | 1.87260586 |
| 19 | MP0003186_abnormal_redox_activity | 1.79724654 |
| 20 | MP0001835_abnormal_antigen_presentation | 1.79332635 |
| 21 | MP0004145_abnormal_muscle_electrophysio | 1.77096401 |
| 22 | MP0008872_abnormal_physiological_respon | 1.75989593 |
| 23 | MP0004147_increased_porphyrin_level | 1.74508730 |
| 24 | MP0003718_maternal_effect | 1.73695601 |
| 25 | MP0005253_abnormal_eye_physiology | 1.62807714 |
| 26 | MP0005075_abnormal_melanosome_morpholog | 1.62180585 |
| 27 | MP0003011_delayed_dark_adaptation | 1.61427272 |
| 28 | MP0005084_abnormal_gallbladder_morpholo | 1.59772715 |
| 29 | MP0009046_muscle_twitch | 1.56273130 |
| 30 | MP0002876_abnormal_thyroid_physiology | 1.50177012 |
| 31 | MP0005646_abnormal_pituitary_gland | 1.49458544 |
| 32 | MP0001764_abnormal_homeostasis | 1.46318687 |
| 33 | MP0002163_abnormal_gland_morphology | 1.41976817 |
| 34 | MP0005551_abnormal_eye_electrophysiolog | 1.40766933 |
| 35 | MP0002736_abnormal_nociception_after | 1.40455707 |
| 36 | MP0009785_altered_susceptibility_to | 1.39568637 |
| 37 | MP0000516_abnormal_urinary_system | 1.37285079 |
| 38 | MP0005367_renal/urinary_system_phenotyp | 1.37285079 |
| 39 | MP0010094_abnormal_chromosome_stability | 1.37107121 |
| 40 | MP0005332_abnormal_amino_acid | 1.30678239 |
| 41 | MP0001873_stomach_inflammation | 1.28556302 |
| 42 | MP0005379_endocrine/exocrine_gland_phen | 1.28094566 |
| 43 | MP0004142_abnormal_muscle_tone | 1.27273901 |
| 44 | MP0004215_abnormal_myocardial_fiber | 1.26319127 |
| 45 | MP0001968_abnormal_touch/_nociception | 1.25583454 |
| 46 | MP0001905_abnormal_dopamine_level | 1.24458362 |
| 47 | MP0005410_abnormal_fertilization | 1.23649167 |
| 48 | MP0003693_abnormal_embryo_hatching | 1.19589946 |
| 49 | MP0008995_early_reproductive_senescence | 1.17741866 |
| 50 | MP0005636_abnormal_mineral_homeostasis | 1.15667726 |
| 51 | MP0002138_abnormal_hepatobiliary_system | 1.14423803 |
| 52 | MP0006276_abnormal_autonomic_nervous | 1.13429927 |
| 53 | MP0002693_abnormal_pancreas_physiology | 1.10613525 |
| 54 | MP0003137_abnormal_impulse_conducting | 1.10180158 |
| 55 | MP0003880_abnormal_central_pattern | 1.09427504 |
| 56 | MP0008007_abnormal_cellular_replicative | 1.06616006 |
| 57 | MP0002090_abnormal_vision | 1.04155151 |
| 58 | MP0001501_abnormal_sleep_pattern | 1.00340914 |
| 59 | MP0009745_abnormal_behavioral_response | 0.99423005 |
| 60 | MP0002277_abnormal_respiratory_mucosa | 0.99289056 |
| 61 | MP0010386_abnormal_urinary_bladder | 0.96874189 |
| 62 | MP0001661_extended_life_span | 0.96665031 |
| 63 | MP0003787_abnormal_imprinting | 0.94653941 |
| 64 | MP0002166_altered_tumor_susceptibility | 0.94590660 |
| 65 | MP0008789_abnormal_olfactory_epithelium | 0.94454000 |
| 66 | MP0002272_abnormal_nervous_system | 0.93320185 |
| 67 | MP0002148_abnormal_hypersensitivity_rea | 0.92187320 |
| 68 | MP0005389_reproductive_system_phenotype | 0.92138367 |
| 69 | MP0001919_abnormal_reproductive_system | 0.88643587 |
| 70 | MP0003567_abnormal_fetal_cardiomyocyte | 0.88516997 |
| 71 | MP0002638_abnormal_pupillary_reflex | 0.88443908 |
| 72 | MP0002751_abnormal_autonomic_nervous | 0.88012280 |
| 73 | MP0006082_CNS_inflammation | 0.87736371 |
| 74 | MP0009333_abnormal_splenocyte_physiolog | 0.87724313 |
| 75 | MP0001929_abnormal_gametogenesis | 0.86774831 |
| 76 | MP0000358_abnormal_cell_content/ | 0.86599143 |
| 77 | MP0005408_hypopigmentation | 0.86428535 |
| 78 | MP0002234_abnormal_pharynx_morphology | 0.85093517 |
| 79 | MP0005266_abnormal_metabolism | 0.84141252 |
| 80 | MP0002909_abnormal_adrenal_gland | 0.80270540 |
| 81 | MP0005330_cardiomyopathy | 0.79789545 |
| 82 | MP0002006_tumorigenesis | 0.78294542 |
| 83 | MP0002938_white_spotting | 0.76497968 |
| 84 | MP0005085_abnormal_gallbladder_physiolo | 0.76273647 |
| 85 | MP0006054_spinal_hemorrhage | 0.76080133 |
| 86 | MP0000749_muscle_degeneration | 0.74332633 |
| 87 | MP0004957_abnormal_blastocyst_morpholog | 0.73157981 |
| 88 | MP0008775_abnormal_heart_ventricle | 0.69456374 |
| 89 | MP0002210_abnormal_sex_determination | 0.68694733 |
| 90 | MP0000653_abnormal_sex_gland | 0.68449356 |
| 91 | MP0002160_abnormal_reproductive_system | 0.67678490 |
| 92 | MP0000639_abnormal_adrenal_gland | 0.67474088 |
| 93 | MP0001119_abnormal_female_reproductive | 0.66790123 |
| 94 | MP0004043_abnormal_pH_regulation | 0.64892724 |
| 95 | MP0004484_altered_response_of | 0.61702330 |
| 96 | MP0002095_abnormal_skin_pigmentation | 0.61533463 |
| 97 | MP0001756_abnormal_urination | 0.60694324 |
| 98 | MP0005386_behavior/neurological_phenoty | 0.59936414 |
| 99 | MP0004924_abnormal_behavior | 0.59936414 |
| 100 | MP0001800_abnormal_humoral_immune | 0.59712100 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.05169157 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.58138674 |
| 3 | Acute encephalopathy (HP:0006846) | 4.47794230 |
| 4 | Progressive macrocephaly (HP:0004481) | 4.45388759 |
| 5 | Mitochondrial inheritance (HP:0001427) | 4.40469939 |
| 6 | Increased CSF lactate (HP:0002490) | 4.20840784 |
| 7 | Hepatocellular necrosis (HP:0001404) | 3.82406908 |
| 8 | Hepatic necrosis (HP:0002605) | 3.66112700 |
| 9 | Cerebral edema (HP:0002181) | 3.51047511 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 3.49438459 |
| 11 | Increased hepatocellular lipid droplets (HP:0006565) | 3.41899960 |
| 12 | 3-Methylglutaconic aciduria (HP:0003535) | 3.35917626 |
| 13 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.35283110 |
| 14 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.35283110 |
| 15 | Methylmalonic acidemia (HP:0002912) | 3.00679894 |
| 16 | Lactic acidosis (HP:0003128) | 2.99883640 |
| 17 | Increased serum lactate (HP:0002151) | 2.93679466 |
| 18 | Hypothermia (HP:0002045) | 2.85898696 |
| 19 | Type I transferrin isoform profile (HP:0003642) | 2.84566268 |
| 20 | Aplastic anemia (HP:0001915) | 2.80678197 |
| 21 | Increased intramyocellular lipid droplets (HP:0012240) | 2.76973646 |
| 22 | Methylmalonic aciduria (HP:0012120) | 2.75665569 |
| 23 | Respiratory failure (HP:0002878) | 2.72539707 |
| 24 | Renal Fanconi syndrome (HP:0001994) | 2.66794726 |
| 25 | Exercise intolerance (HP:0003546) | 2.59994543 |
| 26 | Optic disc pallor (HP:0000543) | 2.59313574 |
| 27 | Lethargy (HP:0001254) | 2.59290382 |
| 28 | Abnormal protein glycosylation (HP:0012346) | 2.57568865 |
| 29 | Abnormal glycosylation (HP:0012345) | 2.57568865 |
| 30 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.57568865 |
| 31 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.57568865 |
| 32 | Hypoproteinemia (HP:0003075) | 2.54249905 |
| 33 | Degeneration of anterior horn cells (HP:0002398) | 2.50358892 |
| 34 | Abnormality of the anterior horn cell (HP:0006802) | 2.50358892 |
| 35 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.46577737 |
| 36 | Increased muscle lipid content (HP:0009058) | 2.43574007 |
| 37 | Pancreatic cysts (HP:0001737) | 2.42763412 |
| 38 | Ketoacidosis (HP:0001993) | 2.35035443 |
| 39 | Stomatitis (HP:0010280) | 2.28574077 |
| 40 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.27921391 |
| 41 | Abolished electroretinogram (ERG) (HP:0000550) | 2.27628388 |
| 42 | Abnormality of alanine metabolism (HP:0010916) | 2.25365381 |
| 43 | Hyperalaninemia (HP:0003348) | 2.25365381 |
| 44 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.25365381 |
| 45 | IgG deficiency (HP:0004315) | 2.25118988 |
| 46 | Renal cortical cysts (HP:0000803) | 2.23202522 |
| 47 | Medial flaring of the eyebrow (HP:0010747) | 2.22091361 |
| 48 | Exertional dyspnea (HP:0002875) | 2.18393163 |
| 49 | Dicarboxylic aciduria (HP:0003215) | 2.17080520 |
| 50 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.17080520 |
| 51 | Leukodystrophy (HP:0002415) | 2.15569899 |
| 52 | CNS demyelination (HP:0007305) | 2.14012342 |
| 53 | Congenital stationary night blindness (HP:0007642) | 2.13430386 |
| 54 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.12661753 |
| 55 | Abnormality of the labia minora (HP:0012880) | 2.07259980 |
| 56 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 2.06468996 |
| 57 | Abnormality of midbrain morphology (HP:0002418) | 2.05358807 |
| 58 | Molar tooth sign on MRI (HP:0002419) | 2.05358807 |
| 59 | Reduced antithrombin III activity (HP:0001976) | 2.01811569 |
| 60 | Ketosis (HP:0001946) | 2.00822127 |
| 61 | Thyroiditis (HP:0100646) | 2.00332829 |
| 62 | Pancreatic fibrosis (HP:0100732) | 2.00313435 |
| 63 | Generalized aminoaciduria (HP:0002909) | 2.00153483 |
| 64 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.00111675 |
| 65 | Abnormality of vitamin B metabolism (HP:0004340) | 1.99224858 |
| 66 | Hyperglycinemia (HP:0002154) | 1.98848018 |
| 67 | Hypoglycemic coma (HP:0001325) | 1.98746326 |
| 68 | True hermaphroditism (HP:0010459) | 1.93016664 |
| 69 | Abnormality of methionine metabolism (HP:0010901) | 1.92526245 |
| 70 | Glycosuria (HP:0003076) | 1.90830104 |
| 71 | Abnormality of urine glucose concentration (HP:0011016) | 1.90830104 |
| 72 | Pancreatic islet-cell hyperplasia (HP:0004510) | 1.89723486 |
| 73 | Cerebral hypomyelination (HP:0006808) | 1.88824669 |
| 74 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.88296624 |
| 75 | Abnormality of serum amino acid levels (HP:0003112) | 1.84310294 |
| 76 | Large for gestational age (HP:0001520) | 1.81786360 |
| 77 | Increased serum pyruvate (HP:0003542) | 1.81462548 |
| 78 | Colon cancer (HP:0003003) | 1.81455475 |
| 79 | Tongue fasciculations (HP:0001308) | 1.81175659 |
| 80 | Microvesicular hepatic steatosis (HP:0001414) | 1.80550265 |
| 81 | Abnormality of the renal cortex (HP:0011035) | 1.79990293 |
| 82 | Progressive microcephaly (HP:0000253) | 1.79377675 |
| 83 | Hyperglycinuria (HP:0003108) | 1.79162584 |
| 84 | Nephrogenic diabetes insipidus (HP:0009806) | 1.78927154 |
| 85 | Short tibia (HP:0005736) | 1.77272734 |
| 86 | Hypoglycemic seizures (HP:0002173) | 1.76233984 |
| 87 | Palpitations (HP:0001962) | 1.75477909 |
| 88 | Congenital primary aphakia (HP:0007707) | 1.74767003 |
| 89 | Neoplasm of the adrenal gland (HP:0100631) | 1.73192029 |
| 90 | X-linked dominant inheritance (HP:0001423) | 1.73126649 |
| 91 | Abnormality of glycine metabolism (HP:0010895) | 1.72858458 |
| 92 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.72858458 |
| 93 | Pancytopenia (HP:0001876) | 1.72675598 |
| 94 | Hypomagnesemia (HP:0002917) | 1.72111499 |
| 95 | Severe combined immunodeficiency (HP:0004430) | 1.71754712 |
| 96 | Abnormality of endocrine pancreas physiology (HP:0012093) | 1.71634058 |
| 97 | Abnormality of the pancreatic islet cells (HP:0006476) | 1.71634058 |
| 98 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.71235114 |
| 99 | Hypoplasia of the fovea (HP:0007750) | 1.69161553 |
| 100 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.69161553 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP4K2 | 3.10225360 |
| 2 | MST4 | 3.03373304 |
| 3 | FRK | 2.99987065 |
| 4 | TRIM28 | 2.90896798 |
| 5 | EIF2AK3 | 2.83873137 |
| 6 | BCKDK | 2.54023104 |
| 7 | TXK | 2.52566063 |
| 8 | WNK3 | 2.31331394 |
| 9 | ZAK | 2.20249248 |
| 10 | NUAK1 | 2.16803516 |
| 11 | VRK2 | 2.06113778 |
| 12 | EIF2AK1 | 2.04020979 |
| 13 | MAP3K12 | 1.96670095 |
| 14 | BCR | 1.95358246 |
| 15 | ADRBK2 | 1.83285385 |
| 16 | TSSK6 | 1.77843929 |
| 17 | GRK1 | 1.76763810 |
| 18 | SRPK1 | 1.74780785 |
| 19 | PINK1 | 1.71911626 |
| 20 | ERBB3 | 1.70800651 |
| 21 | KDR | 1.67152699 |
| 22 | BUB1 | 1.63602911 |
| 23 | TAOK3 | 1.60383264 |
| 24 | CSNK1G3 | 1.55120112 |
| 25 | VRK1 | 1.53201045 |
| 26 | NEK1 | 1.51344189 |
| 27 | CSNK1G1 | 1.49261835 |
| 28 | OBSCN | 1.46500786 |
| 29 | STK16 | 1.45683396 |
| 30 | BMPR1B | 1.42457574 |
| 31 | MAP2K7 | 1.38085225 |
| 32 | PLK3 | 1.38045617 |
| 33 | CSNK1A1L | 1.34088009 |
| 34 | CSNK1G2 | 1.30879709 |
| 35 | PHKG1 | 1.23138674 |
| 36 | PHKG2 | 1.23138674 |
| 37 | INSRR | 1.14532312 |
| 38 | TLK1 | 1.06463233 |
| 39 | OXSR1 | 1.04654903 |
| 40 | PLK2 | 1.02617594 |
| 41 | MAP3K4 | 1.00908812 |
| 42 | PAK3 | 0.98389707 |
| 43 | LIMK1 | 0.96939866 |
| 44 | TIE1 | 0.96818723 |
| 45 | TESK1 | 0.96347309 |
| 46 | DAPK1 | 0.95109898 |
| 47 | PBK | 0.94508912 |
| 48 | MAPK13 | 0.93687674 |
| 49 | TESK2 | 0.90011954 |
| 50 | MKNK2 | 0.86516867 |
| 51 | MYLK | 0.85906810 |
| 52 | NME1 | 0.84364488 |
| 53 | MAP2K6 | 0.81582904 |
| 54 | MKNK1 | 0.79742439 |
| 55 | PDK2 | 0.77422253 |
| 56 | STK39 | 0.75945048 |
| 57 | PRKCE | 0.75229744 |
| 58 | BMPR2 | 0.73755067 |
| 59 | WNK4 | 0.69285998 |
| 60 | PLK1 | 0.66316627 |
| 61 | DYRK2 | 0.64870456 |
| 62 | PLK4 | 0.63999321 |
| 63 | STK38L | 0.63445905 |
| 64 | RPS6KA4 | 0.61315773 |
| 65 | EIF2AK2 | 0.60237859 |
| 66 | ACVR1B | 0.58544075 |
| 67 | RPS6KA5 | 0.58075161 |
| 68 | FER | 0.57427976 |
| 69 | ATR | 0.57334404 |
| 70 | TEC | 0.54858350 |
| 71 | MAPKAPK3 | 0.53551819 |
| 72 | ITK | 0.53451442 |
| 73 | TNK2 | 0.51185739 |
| 74 | CCNB1 | 0.50610564 |
| 75 | CSNK1A1 | 0.50220245 |
| 76 | PRKCQ | 0.47949761 |
| 77 | CAMK2A | 0.47586248 |
| 78 | PRKCG | 0.46740857 |
| 79 | FLT3 | 0.45800216 |
| 80 | PRKCI | 0.45121979 |
| 81 | IKBKB | 0.44035489 |
| 82 | CSNK2A1 | 0.44024853 |
| 83 | SCYL2 | 0.43670905 |
| 84 | CAMKK2 | 0.43407935 |
| 85 | BRSK2 | 0.43165137 |
| 86 | TNIK | 0.42826504 |
| 87 | GRK7 | 0.42232113 |
| 88 | PIM2 | 0.41889651 |
| 89 | CAMK2D | 0.36756630 |
| 90 | ATM | 0.36028651 |
| 91 | MINK1 | 0.35947498 |
| 92 | PRKACA | 0.34661970 |
| 93 | DAPK2 | 0.34205211 |
| 94 | CSNK2A2 | 0.33477575 |
| 95 | ADRBK1 | 0.32945643 |
| 96 | PRKCA | 0.31082371 |
| 97 | SIK3 | 0.30480221 |
| 98 | TTK | 0.29547516 |
| 99 | MAP3K5 | 0.28451804 |
| 100 | AURKB | 0.27909801 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.59040083 |
| 2 | Protein export_Homo sapiens_hsa03060 | 3.59018958 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.29592016 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 2.73675925 |
| 5 | RNA polymerase_Homo sapiens_hsa03020 | 2.27253198 |
| 6 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.16839570 |
| 7 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.05371135 |
| 8 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.93610739 |
| 9 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.88889189 |
| 10 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.84078144 |
| 11 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.82275927 |
| 12 | Homologous recombination_Homo sapiens_hsa03440 | 1.69716071 |
| 13 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.69254715 |
| 14 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.67395170 |
| 15 | Asthma_Homo sapiens_hsa05310 | 1.64931234 |
| 16 | Alzheimers disease_Homo sapiens_hsa05010 | 1.64715173 |
| 17 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.60874544 |
| 18 | Huntingtons disease_Homo sapiens_hsa05016 | 1.58874712 |
| 19 | Mismatch repair_Homo sapiens_hsa03430 | 1.58280045 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.54537505 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.50491390 |
| 22 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.48708341 |
| 23 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.47948560 |
| 24 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.45430596 |
| 25 | Allograft rejection_Homo sapiens_hsa05330 | 1.45291677 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.41878391 |
| 27 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.37629833 |
| 28 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.37186217 |
| 29 | RNA degradation_Homo sapiens_hsa03018 | 1.36795069 |
| 30 | Peroxisome_Homo sapiens_hsa04146 | 1.36775692 |
| 31 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 1.36552401 |
| 32 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.35698527 |
| 33 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.30644550 |
| 34 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.29223941 |
| 35 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.27485942 |
| 36 | Phototransduction_Homo sapiens_hsa04744 | 1.18167049 |
| 37 | DNA replication_Homo sapiens_hsa03030 | 1.17748502 |
| 38 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.17626349 |
| 39 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.17115851 |
| 40 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.15799193 |
| 41 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.13451515 |
| 42 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 1.12422845 |
| 43 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 1.11978923 |
| 44 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.09225145 |
| 45 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.08479468 |
| 46 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.06738753 |
| 47 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.06714221 |
| 48 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.05867007 |
| 49 | RNA transport_Homo sapiens_hsa03013 | 1.03117701 |
| 50 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.99814974 |
| 51 | Base excision repair_Homo sapiens_hsa03410 | 0.99196617 |
| 52 | Purine metabolism_Homo sapiens_hsa00230 | 0.98267239 |
| 53 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.94392303 |
| 54 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.92670114 |
| 55 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.91134488 |
| 56 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.89761364 |
| 57 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.87831325 |
| 58 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.87072889 |
| 59 | Spliceosome_Homo sapiens_hsa03040 | 0.86862783 |
| 60 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.85900191 |
| 61 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.83996359 |
| 62 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.81146087 |
| 63 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.80886755 |
| 64 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.80652923 |
| 65 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.80544674 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.79105515 |
| 67 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.75806472 |
| 68 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.73099392 |
| 69 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.70875337 |
| 70 | Carbon metabolism_Homo sapiens_hsa01200 | 0.69849648 |
| 71 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.68727736 |
| 72 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.68569723 |
| 73 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.67992022 |
| 74 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.66124220 |
| 75 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.64742342 |
| 76 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.64503487 |
| 77 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.63030609 |
| 78 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.61569756 |
| 79 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.61291354 |
| 80 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.61182025 |
| 81 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.58883092 |
| 82 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.58146505 |
| 83 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.55368045 |
| 84 | Retinol metabolism_Homo sapiens_hsa00830 | 0.52358116 |
| 85 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.52121893 |
| 86 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.52112550 |
| 87 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.51971173 |
| 88 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48092684 |
| 89 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.47160880 |
| 90 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.46910810 |
| 91 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.46853808 |
| 92 | Circadian rhythm_Homo sapiens_hsa04710 | 0.43464802 |
| 93 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.42586847 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.42470043 |
| 95 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.40939226 |
| 96 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39224077 |
| 97 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.37738602 |
| 98 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.36466572 |
| 99 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.34741375 |
| 100 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.32708760 |

