NDUFV3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of at least forty-one subunits that make up the NADH-ubiquinone oxidoreductase complex. This complex is part of the mitochondrial respiratory chain and serves to catalyze the rotenone-sensitive oxidation of NADH and the reduction of ubiquinone. The encoded protein is one of three proteins found in the flavoprotein fraction of the complex. The specific function of the encoded protein is unknown. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)9.51074794
2energy coupled proton transport, down electrochemical gradient (GO:0015985)8.96791450
3ATP synthesis coupled proton transport (GO:0015986)8.96791450
4* mitochondrial electron transport, NADH to ubiquinone (GO:0006120)8.69074120
5* respiratory electron transport chain (GO:0022904)7.92619142
6* electron transport chain (GO:0022900)7.73883218
7behavioral response to nicotine (GO:0035095)6.13281851
8ATP biosynthetic process (GO:0006754)5.05046719
9hydrogen ion transmembrane transport (GO:1902600)4.83094422
10inner mitochondrial membrane organization (GO:0007007)4.61800115
11protein complex biogenesis (GO:0070271)4.60508294
12membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.54584218
13purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.53139246
14purine nucleoside triphosphate biosynthetic process (GO:0009145)4.44419777
15oxidative phosphorylation (GO:0006119)4.43265674
16protein neddylation (GO:0045116)4.30290577
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.29017845
18chaperone-mediated protein transport (GO:0072321)4.28751858
19proton transport (GO:0015992)4.23928795
20hydrogen transport (GO:0006818)4.17209275
21mitochondrial respiratory chain complex assembly (GO:0033108)4.13894049
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.06595133
23NADH dehydrogenase complex assembly (GO:0010257)4.06595133
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.06595133
25ribonucleoside triphosphate biosynthetic process (GO:0009201)3.92335806
26membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.85957186
27translational termination (GO:0006415)3.76475503
28membrane repolarization during action potential (GO:0086011)3.67131288
29regulation of oxidative phosphorylation (GO:0002082)3.66288710
30water-soluble vitamin biosynthetic process (GO:0042364)3.58737731
31tricarboxylic acid cycle (GO:0006099)3.42579523
32regulation of mitochondrial translation (GO:0070129)3.33276027
33dopamine transport (GO:0015872)3.30666306
34nucleoside triphosphate biosynthetic process (GO:0009142)3.26259221
35positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.25637337
36somite development (GO:0061053)3.24707854
37negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.24273277
38positive regulation of fatty acid oxidation (GO:0046321)3.22582612
39regulation of mesoderm development (GO:2000380)3.22411738
40dopamine biosynthetic process (GO:0042416)3.20198678
41regulation of cell communication by electrical coupling (GO:0010649)3.19535073
42sarcomere organization (GO:0045214)3.18738021
43respiratory chain complex IV assembly (GO:0008535)3.18447877
44regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.15533083
45* generation of precursor metabolites and energy (GO:0006091)3.14918440
46regulation of membrane repolarization (GO:0060306)3.05587120
47regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.04773879
48ubiquinone biosynthetic process (GO:0006744)3.03646027
49quinone biosynthetic process (GO:1901663)3.03646027
50cytochrome complex assembly (GO:0017004)3.02684667
51calcium-mediated signaling using intracellular calcium source (GO:0035584)3.01327326
52cell proliferation in forebrain (GO:0021846)3.01080856
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.99767034
54ATP hydrolysis coupled proton transport (GO:0015991)2.99767034
55regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.99251146
56translational elongation (GO:0006414)2.99153772
57sulfation (GO:0051923)2.98835583
58cellular ketone body metabolic process (GO:0046950)2.97083230
59serotonin metabolic process (GO:0042428)2.93996359
60aerobic respiration (GO:0009060)2.93190033
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93078647
62mitochondrial transport (GO:0006839)2.93065907
63negative regulation of transcription regulatory region DNA binding (GO:2000678)2.93040204
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.91931975
65NADH metabolic process (GO:0006734)2.91827521
66detection of calcium ion (GO:0005513)2.90489685
67cotranslational protein targeting to membrane (GO:0006613)2.89911731
68sarcoplasmic reticulum calcium ion transport (GO:0070296)2.89121579
69maturation of SSU-rRNA (GO:0030490)2.88994635
70ubiquinone metabolic process (GO:0006743)2.88844756
71indolalkylamine metabolic process (GO:0006586)2.88530994
72regulation of skeletal muscle contraction (GO:0014819)2.87578422
73regulation of acyl-CoA biosynthetic process (GO:0050812)2.86708495
74protein targeting to ER (GO:0045047)2.85869557
75DNA deamination (GO:0045006)2.85723471
76fatty acid elongation (GO:0030497)2.84810640
77primary amino compound metabolic process (GO:1901160)2.84467828
78negative regulation of protein localization to cell surface (GO:2000009)2.84028937
79cellular response to epinephrine stimulus (GO:0071872)2.82978089
80response to epinephrine (GO:0071871)2.82381715
81regulation of relaxation of muscle (GO:1901077)2.80141702
82nonmotile primary cilium assembly (GO:0035058)2.79817088
83substantia nigra development (GO:0021762)2.76629387
84positive regulation of potassium ion transmembrane transport (GO:1901381)2.76459409
85regulation of catecholamine metabolic process (GO:0042069)2.76291735
86regulation of dopamine metabolic process (GO:0042053)2.76291735
87regulation of actin filament-based movement (GO:1903115)2.75704381
88membrane repolarization (GO:0086009)2.75508980
89cardiovascular system development (GO:0072358)2.75483960
90cellular protein complex disassembly (GO:0043624)2.74582568
91kynurenine metabolic process (GO:0070189)2.73393668
92establishment of protein localization to endoplasmic reticulum (GO:0072599)2.71710524
93GTP biosynthetic process (GO:0006183)2.71463092
94heart process (GO:0003015)2.71220519
95heart contraction (GO:0060047)2.71220519
96spinal cord motor neuron differentiation (GO:0021522)2.69670160
97retinal ganglion cell axon guidance (GO:0031290)2.67693125
98ketone body metabolic process (GO:1902224)2.67655720
99succinate metabolic process (GO:0006105)2.67478948
100protein localization to endoplasmic reticulum (GO:0070972)2.66687113
101positive regulation of fatty acid beta-oxidation (GO:0032000)2.64134500
102spinal cord development (GO:0021510)2.63449870
103regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62631399
104ribosomal small subunit biogenesis (GO:0042274)2.61853819
105purine nucleoside monophosphate biosynthetic process (GO:0009127)2.60753151
106purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.60753151
107epithelial cilium movement (GO:0003351)2.60162558
108viral life cycle (GO:0019058)2.59633528
109positive regulation of action potential (GO:0045760)2.59285680
110central nervous system myelination (GO:0022010)2.58838664
111axon ensheathment in central nervous system (GO:0032291)2.58838664
112membrane depolarization during action potential (GO:0086010)2.58782836
113thalamus development (GO:0021794)2.58345267
114platelet dense granule organization (GO:0060155)2.57938857
115protein polyglutamylation (GO:0018095)2.57692060
116positive regulation of gastrulation (GO:2000543)2.57560830
117regulation of coenzyme metabolic process (GO:0051196)2.56035932
118regulation of cofactor metabolic process (GO:0051193)2.56035932
119negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.55109657
120ribosomal small subunit assembly (GO:0000028)2.54885609
121negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.52300949
122negative regulation of calcium ion transmembrane transport (GO:1903170)2.52300949
123nephron epithelium morphogenesis (GO:0072088)2.51958321
124nephron tubule morphogenesis (GO:0072078)2.51958321
125L-fucose catabolic process (GO:0042355)2.50318545
126fucose catabolic process (GO:0019317)2.50318545
127L-fucose metabolic process (GO:0042354)2.50318545
128branched-chain amino acid catabolic process (GO:0009083)2.50136888
129indole-containing compound catabolic process (GO:0042436)2.49305709
130indolalkylamine catabolic process (GO:0046218)2.49305709
131tryptophan catabolic process (GO:0006569)2.49305709
132gamma-aminobutyric acid transport (GO:0015812)2.48536950
133regulation of cellular respiration (GO:0043457)2.47837895
134purine ribonucleoside biosynthetic process (GO:0046129)2.46647817
135purine nucleoside biosynthetic process (GO:0042451)2.46647817
136intracellular protein transmembrane import (GO:0044743)2.45740703
137indole-containing compound metabolic process (GO:0042430)2.45235323
138cardiac myofibril assembly (GO:0055003)2.44318995
139response to redox state (GO:0051775)2.42981885
140termination of RNA polymerase III transcription (GO:0006386)2.42967369
141transcription elongation from RNA polymerase III promoter (GO:0006385)2.42967369
142negative regulation of systemic arterial blood pressure (GO:0003085)2.42581122
143muscle filament sliding (GO:0030049)2.42380451
144actin-myosin filament sliding (GO:0033275)2.42380451
145myofibril assembly (GO:0030239)2.42289242
146alkaloid metabolic process (GO:0009820)2.41153747
147regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.40564711
148negative regulation of telomere maintenance (GO:0032205)2.40369835
149regulation of posttranscriptional gene silencing (GO:0060147)2.39856058
150regulation of gene silencing by miRNA (GO:0060964)2.39856058
151regulation of gene silencing by RNA (GO:0060966)2.39856058
152pharyngeal system development (GO:0060037)2.39467750
153synaptic transmission, cholinergic (GO:0007271)2.39201037
154negative regulation of response to food (GO:0032096)2.37577200
155negative regulation of appetite (GO:0032099)2.37577200
156neuron cell-cell adhesion (GO:0007158)2.37416376
157outer ear morphogenesis (GO:0042473)2.37377456
158negative regulation of potassium ion transmembrane transport (GO:1901380)2.37339179
159neuronal action potential (GO:0019228)2.37275740
160protein-cofactor linkage (GO:0018065)2.37065342
161cardiac muscle contraction (GO:0060048)2.37046327
162ventricular cardiac muscle cell action potential (GO:0086005)2.35859477
163aldehyde catabolic process (GO:0046185)2.35559505
164nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.35212573
165regulation of striated muscle contraction (GO:0006942)2.35170505
166viral transcription (GO:0019083)2.34409644
167establishment of protein localization to mitochondrion (GO:0072655)2.34050609
168protein targeting to mitochondrion (GO:0006626)2.33952799
169cellular response to ATP (GO:0071318)2.33710831
170cardiac muscle tissue morphogenesis (GO:0055008)2.33267594
171mitochondrion morphogenesis (GO:0070584)2.32734402
172parturition (GO:0007567)2.32606197
173neuron fate specification (GO:0048665)2.32294599
174protein import into peroxisome matrix (GO:0016558)2.29796494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.93369011
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.67237894
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.85522690
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.74672773
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.70064934
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62889078
7VDR_22108803_ChIP-Seq_LS180_Human2.57179724
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.48875874
9GBX2_23144817_ChIP-Seq_PC3_Human2.35429615
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25448451
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21490842
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16529620
13TAF15_26573619_Chip-Seq_HEK293_Human2.11162606
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05602796
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.02286755
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98394999
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96192114
18BP1_19119308_ChIP-ChIP_Hs578T_Human1.94932869
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90436789
20EWS_26573619_Chip-Seq_HEK293_Human1.86625280
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86250008
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84099474
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76850319
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76737215
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.72973227
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71450441
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.69225867
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.69140510
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.69140510
30RNF2_27304074_Chip-Seq_NSC_Mouse1.67591719
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67122346
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.66009733
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65007973
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63976031
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63085777
36GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63026531
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.62182193
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58566640
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56819192
40MYC_18940864_ChIP-ChIP_HL60_Human1.54181963
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.54149541
42SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53647087
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.51577558
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51096262
45* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47940543
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.47244009
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41537223
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40987175
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39089369
50REST_21632747_ChIP-Seq_MESCs_Mouse1.39034055
51CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37983276
52TP53_20018659_ChIP-ChIP_R1E_Mouse1.33634374
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33118524
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.31669558
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.24599588
56NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23255015
57TP53_22573176_ChIP-Seq_HFKS_Human1.23087025
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22527568
59IGF1R_20145208_ChIP-Seq_DFB_Human1.20597306
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20506418
61REST_18959480_ChIP-ChIP_MESCs_Mouse1.19951647
62EST1_17652178_ChIP-ChIP_JURKAT_Human1.19739733
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19077458
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18376511
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.17922410
66P300_19829295_ChIP-Seq_ESCs_Human1.17187280
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16464450
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16254702
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13758889
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13454206
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13370148
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12364342
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11283972
74ER_23166858_ChIP-Seq_MCF-7_Human1.09958048
75HTT_18923047_ChIP-ChIP_STHdh_Human1.09645325
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09140969
77ERA_21632823_ChIP-Seq_H3396_Human1.09015219
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07992738
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07244640
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.06822275
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06086530
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.06086530
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05002614
84ZNF274_21170338_ChIP-Seq_K562_Hela1.04438820
85CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04430469
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04252623
87TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04252623
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03803433
89* AR_25329375_ChIP-Seq_VCAP_Human1.03357847
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01882782
91RNF2_27304074_Chip-Seq_ESCs_Mouse1.01601402
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.01342855
93PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01248739
94LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01071672
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.00634813
96ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98518000
97TAF2_19829295_ChIP-Seq_ESCs_Human0.98287994
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97670818
99STAT3_23295773_ChIP-Seq_U87_Human0.96897969
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96413791
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95984651
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95616418
103TCF4_23295773_ChIP-Seq_U87_Human0.95215069
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94044209
105SMAD3_21741376_ChIP-Seq_EPCs_Human0.94004344
106FLI1_27457419_Chip-Seq_LIVER_Mouse0.93989296
107CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93658564
108* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93444749
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.91462420
110P53_21459846_ChIP-Seq_SAOS-2_Human0.91362339
111HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91362117
112ERG_21242973_ChIP-ChIP_JURKAT_Human0.91225704
113CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90166640
114FUS_26573619_Chip-Seq_HEK293_Human0.89688950
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89593195
116CTCF_27219007_Chip-Seq_Bcells_Human0.89261577
117CBP_20019798_ChIP-Seq_JUKART_Human0.88721608
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88721608
119PCGF2_27294783_Chip-Seq_ESCs_Mouse0.88138429
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86595833
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.84831917
122SMAD4_21799915_ChIP-Seq_A2780_Human0.84280768
123PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84254205
124BCAT_22108803_ChIP-Seq_LS180_Human0.84171935
125RAD21_21589869_ChIP-Seq_MESCs_Mouse0.82870736
126* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81764343
127NANOG_19829295_ChIP-Seq_ESCs_Human0.81182973
128SOX2_19829295_ChIP-Seq_ESCs_Human0.81182973
129IRF1_19129219_ChIP-ChIP_H3396_Human0.81061303
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80431197
131ETS1_20019798_ChIP-Seq_JURKAT_Human0.80400924
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79607959
133* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77968091
134YY1_21170310_ChIP-Seq_MESCs_Mouse0.77819342
135NANOG_20526341_ChIP-Seq_ESCs_Human0.76968349
136HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.76868180
137* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76460079
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76240571
139PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76153429
140AR_21572438_ChIP-Seq_LNCaP_Human0.76087918
141NCOR_22424771_ChIP-Seq_293T_Human0.75040462
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74718024
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.74436481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.67656649
2MP0003646_muscle_fatigue3.35228029
3MP0003880_abnormal_central_pattern3.05296909
4MP0000751_myopathy2.94004313
5MP0001529_abnormal_vocalization2.88188116
6MP0004215_abnormal_myocardial_fiber2.65183685
7MP0004036_abnormal_muscle_relaxation2.49633903
8MP0006292_abnormal_olfactory_placode2.49563109
9MP0004084_abnormal_cardiac_muscle2.44190792
10MP0006276_abnormal_autonomic_nervous2.44064500
11MP0006036_abnormal_mitochondrial_physio2.32810009
12MP0001905_abnormal_dopamine_level2.31480522
13MP0009379_abnormal_foot_pigmentation2.27712620
14MP0002822_catalepsy2.25969992
15MP0000749_muscle_degeneration2.06702226
16MP0002938_white_spotting2.02074547
17MP0003283_abnormal_digestive_organ2.01989754
18MP0005330_cardiomyopathy2.00347138
19MP0003137_abnormal_impulse_conducting1.93498358
20MP0002653_abnormal_ependyma_morphology1.86553238
21MP0002102_abnormal_ear_morphology1.84720299
22MP0000569_abnormal_digit_pigmentation1.82043609
23MP0004133_heterotaxia1.81294476
24MP0010030_abnormal_orbit_morphology1.76274848
25MP0000631_abnormal_neuroendocrine_gland1.74731879
26MP0004885_abnormal_endolymph1.74355139
27MP0002234_abnormal_pharynx_morphology1.73612604
28MP0000049_abnormal_middle_ear1.72860454
29MP0005646_abnormal_pituitary_gland1.72414510
30MP0002736_abnormal_nociception_after1.72403835
31MP0006035_abnormal_mitochondrial_morpho1.66016508
32MP0002160_abnormal_reproductive_system1.65618981
33MP0002735_abnormal_chemical_nociception1.65367595
34MP0002272_abnormal_nervous_system1.64948987
35MP0002972_abnormal_cardiac_muscle1.64701923
36MP0001440_abnormal_grooming_behavior1.64334703
37MP0002638_abnormal_pupillary_reflex1.63707167
38MP0004145_abnormal_muscle_electrophysio1.63214472
39MP0001968_abnormal_touch/_nociception1.62885098
40MP0004142_abnormal_muscle_tone1.56912713
41MP0003011_delayed_dark_adaptation1.54613754
42MP0004043_abnormal_pH_regulation1.54276636
43MP0002064_seizures1.51360024
44MP0004085_abnormal_heartbeat1.47682132
45MP0009745_abnormal_behavioral_response1.46682363
46MP0005620_abnormal_muscle_contractility1.44557397
47MP0009046_muscle_twitch1.43066839
48MP0004924_abnormal_behavior1.39303891
49MP0005386_behavior/neurological_phenoty1.39303891
50MP0004484_altered_response_of1.39104820
51MP0002734_abnormal_mechanical_nocicepti1.38819932
52MP0001984_abnormal_olfaction1.35051855
53MP0003195_calcinosis1.34874315
54MP0001970_abnormal_pain_threshold1.33822939
55MP0000026_abnormal_inner_ear1.33139355
56MP0005083_abnormal_biliary_tract1.32372271
57MP0005535_abnormal_body_temperature1.31762315
58MP0004270_analgesia1.31603989
59MP0003937_abnormal_limbs/digits/tail_de1.30249446
60MP0003879_abnormal_hair_cell1.29593030
61MP0005174_abnormal_tail_pigmentation1.29399813
62MP0001486_abnormal_startle_reflex1.28477503
63MP0006072_abnormal_retinal_apoptosis1.28440518
64MP0003635_abnormal_synaptic_transmissio1.28433184
65MP0003938_abnormal_ear_development1.28362700
66MP0002332_abnormal_exercise_endurance1.27618901
67MP0008775_abnormal_heart_ventricle1.25941403
68MP0003806_abnormal_nucleotide_metabolis1.25502200
69MP0002106_abnormal_muscle_physiology1.25444603
70MP0008877_abnormal_DNA_methylation1.24223837
71MP0002067_abnormal_sensory_capabilities1.24184275
72MP0010386_abnormal_urinary_bladder1.24129792
73MP0002572_abnormal_emotion/affect_behav1.24118460
74MP0002733_abnormal_thermal_nociception1.23059247
75MP0000566_synostosis1.20625982
76MP0002876_abnormal_thyroid_physiology1.20069469
77MP0009250_abnormal_appendicular_skeleto1.19552966
78MP0003119_abnormal_digestive_system1.19500067
79MP0000750_abnormal_muscle_regeneration1.17909462
80MP0001544_abnormal_cardiovascular_syste1.13841366
81MP0005385_cardiovascular_system_phenoty1.13841366
82MP0004130_abnormal_muscle_cell1.13453376
83MP0005409_darkened_coat_color1.12978270
84MP0005389_reproductive_system_phenotype1.12800580
85MP0008872_abnormal_physiological_respon1.12608410
86MP0005551_abnormal_eye_electrophysiolog1.11807451
87MP0001501_abnormal_sleep_pattern1.11232669
88MP0002277_abnormal_respiratory_mucosa1.09804130
89MP0004087_abnormal_muscle_fiber1.09564600
90MP0005451_abnormal_body_composition1.09451998
91MP0006138_congestive_heart_failure1.07839467
92MP0000747_muscle_weakness1.07696162
93MP0005369_muscle_phenotype1.05343673
94MP0003136_yellow_coat_color1.05231849
95MP0000920_abnormal_myelination1.04283485
96MP0001293_anophthalmia1.04148193
97MP0000230_abnormal_systemic_arterial1.04137275
98MP0002249_abnormal_larynx_morphology1.03176511
99MP0005195_abnormal_posterior_eye1.01064389
100MP0000372_irregular_coat_pigmentation1.00822800
101MP0005379_endocrine/exocrine_gland_phen1.00216762
102MP0002752_abnormal_somatic_nervous0.97602944
103MP0002229_neurodegeneration0.97577838
104MP0000013_abnormal_adipose_tissue0.97296776
105MP0008995_early_reproductive_senescence0.96787550
106MP0005670_abnormal_white_adipose0.96734016
107MP0001963_abnormal_hearing_physiology0.96215803
108MP0005423_abnormal_somatic_nervous0.95985874
109MP0004742_abnormal_vestibular_system0.94978462
110MP0003878_abnormal_ear_physiology0.94868049
111MP0005377_hearing/vestibular/ear_phenot0.94868049
112MP0003329_amyloid_beta_deposits0.93192214
113MP0002063_abnormal_learning/memory/cond0.92985596
114MP0003890_abnormal_embryonic-extraembry0.92493846
115MP0000759_abnormal_skeletal_muscle0.91481510
116MP0001485_abnormal_pinna_reflex0.91003620
117MP0005332_abnormal_amino_acid0.90151586
118MP0008875_abnormal_xenobiotic_pharmacok0.88243919
119MP0002184_abnormal_innervation0.87645172
120MP0001727_abnormal_embryo_implantation0.87638145
121MP0001664_abnormal_digestion0.87464789
122MP0002928_abnormal_bile_duct0.86981133
123MP0003942_abnormal_urinary_system0.86755193
124MP0008789_abnormal_olfactory_epithelium0.86561852
125MP0000427_abnormal_hair_cycle0.85200323
126MP0001986_abnormal_taste_sensitivity0.84393510
127MP0005645_abnormal_hypothalamus_physiol0.84024335
128MP0002095_abnormal_skin_pigmentation0.83273200
129MP0000955_abnormal_spinal_cord0.81852044
130MP0003950_abnormal_plasma_membrane0.81838693
131MP0005187_abnormal_penis_morphology0.81816023
132MP0005253_abnormal_eye_physiology0.81736840
133MP0002269_muscular_atrophy0.80588672
134MP0002066_abnormal_motor_capabilities/c0.79122125
135MP0005171_absent_coat_pigmentation0.78931684
136MP0000538_abnormal_urinary_bladder0.78725737
137MP0002090_abnormal_vision0.78115937
138MP0003315_abnormal_perineum_morphology0.78028925
139MP0005636_abnormal_mineral_homeostasis0.77983659
140MP0009053_abnormal_anal_canal0.77687955
141MP0000778_abnormal_nervous_system0.77421637
142MP0001502_abnormal_circadian_rhythm0.76439486
143MP0002557_abnormal_social/conspecific_i0.76109203
144MP0002163_abnormal_gland_morphology0.75845850
145MP0005085_abnormal_gallbladder_physiolo0.75620830

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.16943741
2Abnormal mitochondria in muscle tissue (HP:0008316)6.60284611
3Mitochondrial inheritance (HP:0001427)6.25513820
4Acute encephalopathy (HP:0006846)6.16822840
5Progressive macrocephaly (HP:0004481)6.06731460
6Hepatocellular necrosis (HP:0001404)5.32427714
7Increased CSF lactate (HP:0002490)5.27005211
8Hepatic necrosis (HP:0002605)5.02181335
9Increased hepatocellular lipid droplets (HP:0006565)4.84772054
10Lipid accumulation in hepatocytes (HP:0006561)4.68408054
11Cerebral edema (HP:0002181)4.65761896
12Increased intramyocellular lipid droplets (HP:0012240)4.35431696
13Renal Fanconi syndrome (HP:0001994)4.27413333
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.15223711
15Increased muscle lipid content (HP:0009058)4.13523738
16Optic disc pallor (HP:0000543)3.85616521
17Exercise intolerance (HP:0003546)3.84892210
18Lactic acidosis (HP:0003128)3.82167813
19Pancreatic cysts (HP:0001737)3.80887828
20Respiratory failure (HP:0002878)3.80711891
21Sudden death (HP:0001699)3.79580005
22Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.62242736
23Pancreatic fibrosis (HP:0100732)3.58257107
24Abnormality of midbrain morphology (HP:0002418)3.57661818
25Molar tooth sign on MRI (HP:0002419)3.57661818
26Muscle hypertrophy of the lower extremities (HP:0008968)3.47534670
27Calf muscle hypertrophy (HP:0008981)3.47502113
28Leukodystrophy (HP:0002415)3.46064218
29Increased serum pyruvate (HP:0003542)3.37288392
30Abnormality of glycolysis (HP:0004366)3.37288392
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.32528210
32Decreased activity of mitochondrial respiratory chain (HP:0008972)3.32528210
33True hermaphroditism (HP:0010459)3.28741382
34Nephronophthisis (HP:0000090)3.23242616
353-Methylglutaconic aciduria (HP:0003535)3.20031103
36Pheochromocytoma (HP:0002666)3.17380944
37Increased serum lactate (HP:0002151)3.10204751
38Abnormal number of erythroid precursors (HP:0012131)3.07143055
39Abnormality of renal resorption (HP:0011038)3.06099063
40Decreased circulating renin level (HP:0003351)3.02810997
41Neuroendocrine neoplasm (HP:0100634)2.99893062
42Palpitations (HP:0001962)2.99872108
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.98154050
44Abnormality of alanine metabolism (HP:0010916)2.98154050
45Hyperalaninemia (HP:0003348)2.98154050
46Congenital stationary night blindness (HP:0007642)2.97481506
47Exertional dyspnea (HP:0002875)2.97261837
48Concave nail (HP:0001598)2.94436752
49Congenital, generalized hypertrichosis (HP:0004540)2.91371464
50Ventricular tachycardia (HP:0004756)2.85004753
51Clumsiness (HP:0002312)2.75216057
52Respiratory difficulties (HP:0002880)2.70545837
53Type II lissencephaly (HP:0007260)2.69877292
54Abnormality of urine glucose concentration (HP:0011016)2.69449795
55Glycosuria (HP:0003076)2.69449795
56Sclerocornea (HP:0000647)2.66165738
57Abnormality of the renal medulla (HP:0100957)2.61215500
58Lethargy (HP:0001254)2.59784249
59Syncope (HP:0001279)2.57602037
60Exercise-induced myalgia (HP:0003738)2.55504311
61Abnormality of the renal collecting system (HP:0004742)2.52786355
62Hypothermia (HP:0002045)2.52171192
63Myoglobinuria (HP:0002913)2.50521603
64Aplasia/Hypoplasia of the patella (HP:0006498)2.49296441
65Prolonged QT interval (HP:0001657)2.48343949
66X-linked dominant inheritance (HP:0001423)2.47212208
67Atrial fibrillation (HP:0005110)2.46978674
68Patellar aplasia (HP:0006443)2.46625352
69Dicarboxylic aciduria (HP:0003215)2.45621755
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.45621755
71Tubular atrophy (HP:0000092)2.40779500
72Hyperphosphaturia (HP:0003109)2.40393496
73Abnormality of the calf musculature (HP:0001430)2.38748642
74Reticulocytopenia (HP:0001896)2.38492177
75Abnormality of the renal cortex (HP:0011035)2.37390404
76Abolished electroretinogram (ERG) (HP:0000550)2.36870332
77Myokymia (HP:0002411)2.35923196
78Genetic anticipation (HP:0003743)2.35490140
79Primary atrial arrhythmia (HP:0001692)2.34262751
80Myotonia (HP:0002486)2.33333153
81Birth length less than 3rd percentile (HP:0003561)2.32620857
82Supraventricular tachycardia (HP:0004755)2.31010497
83Muscle fiber splitting (HP:0003555)2.30596823
84Pendular nystagmus (HP:0012043)2.29435811
85Lipoatrophy (HP:0100578)2.28549374
86Progressive cerebellar ataxia (HP:0002073)2.27918104
87Aplasia/Hypoplasia of the tibia (HP:0005772)2.27732576
88Ketoacidosis (HP:0001993)2.26949499
89Abnormal drinking behavior (HP:0030082)2.26130347
90Polydipsia (HP:0001959)2.26130347
91Cystic liver disease (HP:0006706)2.25590155
92Absent thumb (HP:0009777)2.25108230
93Decreased electroretinogram (ERG) amplitude (HP:0000654)2.24522729
94Supraventricular arrhythmia (HP:0005115)2.22712651
95Medial flaring of the eyebrow (HP:0010747)2.21384464
96Abnormal urine phosphate concentration (HP:0012599)2.19695128
97Furrowed tongue (HP:0000221)2.18967186
98CNS demyelination (HP:0007305)2.18466297
99Hyperventilation (HP:0002883)2.17974411
100Anencephaly (HP:0002323)2.16476397
101Cerebral hemorrhage (HP:0001342)2.16238337
102Large for gestational age (HP:0001520)2.14319279
103Absent/shortened dynein arms (HP:0200106)2.14111744
104Dynein arm defect of respiratory motile cilia (HP:0012255)2.14111744
105Limb dystonia (HP:0002451)2.11583005
106Rhabdomyolysis (HP:0003201)2.11355878
107Emotional lability (HP:0000712)2.11099342
108Vomiting (HP:0002013)2.08135540
109Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.08056743
110Dilated cardiomyopathy (HP:0001644)2.07418051
111Hypoplasia of the pons (HP:0012110)2.02298464
112Abnormal respiratory epithelium morphology (HP:0012253)2.00121333
113Abnormal respiratory motile cilium morphology (HP:0005938)2.00121333
114Maternal diabetes (HP:0009800)1.99795119
115Broad-based gait (HP:0002136)1.99592977
116Exercise-induced muscle cramps (HP:0003710)1.97726467
117Conjunctival hamartoma (HP:0100780)1.97329204
118Sensory axonal neuropathy (HP:0003390)1.97173000
119Abnormality of the pons (HP:0007361)1.96263752
120Chronic hepatic failure (HP:0100626)1.95191328
121Duplicated collecting system (HP:0000081)1.93413115
122Left ventricular hypertrophy (HP:0001712)1.93403713
123Severe muscular hypotonia (HP:0006829)1.92514739
124Chorioretinal atrophy (HP:0000533)1.92513241
125Muscle stiffness (HP:0003552)1.91549996
126Hypoplasia of the uterus (HP:0000013)1.91164734
127Methylmalonic aciduria (HP:0012120)1.90625682
128Stenosis of the external auditory canal (HP:0000402)1.90332165
129Short hallux (HP:0010109)1.90186161
130Abnormal pupillary function (HP:0007686)1.89413933
131Abnormality of fatty-acid metabolism (HP:0004359)1.88147786
132Male pseudohermaphroditism (HP:0000037)1.88131197
133Renal tubular dysfunction (HP:0000124)1.87385668
134Aplasia/hypoplasia of the uterus (HP:0008684)1.86929519
135Congenital hepatic fibrosis (HP:0002612)1.86750315
136Generalized aminoaciduria (HP:0002909)1.86649565
137Short tibia (HP:0005736)1.84421505
138Ragged-red muscle fibers (HP:0003200)1.83355201
139Abnormal ciliary motility (HP:0012262)1.82198640
140Hypoplasia of the ulna (HP:0003022)1.82066502
141Macrocytic anemia (HP:0001972)1.81935544
142Retinal dysplasia (HP:0007973)1.79001056
143Aplasia/Hypoplasia of the tongue (HP:0010295)1.78769529
144Anophthalmia (HP:0000528)1.78316990
145Aplasia/Hypoplasia of the hallux (HP:0008362)1.77575340
146Methylmalonic acidemia (HP:0002912)1.77529158
147Inability to walk (HP:0002540)1.77338216
148Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77231734
149Gait imbalance (HP:0002141)1.76272030
150Ketosis (HP:0001946)1.76083676
151Pallor (HP:0000980)1.75934531
152Abnormality of cells of the erythroid lineage (HP:0012130)1.75837953
153Rib fusion (HP:0000902)1.75610157
154Cerebellar dysplasia (HP:0007033)1.74666913
155Congenital sensorineural hearing impairment (HP:0008527)1.74523952
156Polyuria (HP:0000103)1.74053934
157Parakeratosis (HP:0001036)1.72167671
158Increased corneal curvature (HP:0100692)1.71243076
159Keratoconus (HP:0000563)1.71243076
160Septo-optic dysplasia (HP:0100842)1.70944806
161Progressive external ophthalmoplegia (HP:0000590)1.70814634
162Abnormal EKG (HP:0003115)1.70387486
163EMG: myopathic abnormalities (HP:0003458)1.69298623
164Hyporeflexia of lower limbs (HP:0002600)1.68498492
165Megalencephaly (HP:0001355)1.68043751
166Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68032330
167Bulbous nose (HP:0000414)1.67520836
168Focal motor seizures (HP:0011153)1.67405015
169Blindness (HP:0000618)1.65820739
170Abnormality of aromatic amino acid family metabolism (HP:0004338)1.64199061
171Hypoplastic left heart (HP:0004383)1.63615596
172Metabolic acidosis (HP:0001942)1.62128208
173Hypoglycemic coma (HP:0001325)1.61119613
174Gliosis (HP:0002171)1.59641833
175Congenital ichthyosiform erythroderma (HP:0007431)1.59174337
176Testicular atrophy (HP:0000029)1.58003659
177Anxiety (HP:0000739)1.56807805
178Athetosis (HP:0002305)1.56333893
179Rimmed vacuoles (HP:0003805)1.55809326

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.52052933
2MYLK3.50095508
3STK392.94495112
4ZAK2.83834129
5GRK72.78978484
6WNK42.73846590
7MAP3K122.72795241
8MUSK2.62137712
9GRK12.60181537
10NME12.57732460
11GRK52.50243046
12NME22.45146705
13BCKDK2.42467135
14PHKG12.35770862
15PHKG22.35770862
16ARAF2.27426837
17OBSCN2.25454116
18ACVR1B2.15837903
19CASK2.02861324
20VRK22.00564656
21OXSR11.89721731
22PIK3CA1.89153926
23PNCK1.83870000
24CAMK2D1.77632728
25TNIK1.75310862
26STK161.69075522
27TAF11.63306632
28NUAK11.60777451
29LMTK21.56437747
30PKN11.49103345
31TAOK31.47160806
32MAPKAPK51.43600310
33ADRBK21.34024787
34INSRR1.30266015
35FGR1.27879838
36CAMK2A1.26679111
37CAMK2B1.26432871
38TTN1.22047561
39DAPK21.21527422
40MAP4K21.20691281
41UHMK11.20605320
42PINK11.18371553
43MAP2K71.17525346
44ADRBK11.14525883
45PDK31.11475285
46PDK41.11475285
47STK111.07887910
48PBK1.07604220
49BRAF1.07550005
50WNK31.07312852
51CAMK2G1.05441832
52PRKCE1.03525399
53LIMK11.03188495
54MST1R1.01587656
55PAK31.01255942
56MAPKAPK31.01181222
57DAPK31.01071294
58MAP2K20.97768168
59TGFBR10.96131277
60RPS6KA50.94924347
61RPS6KA60.94406910
62MAP3K40.94075820
63MAPK130.93993628
64MST40.93012528
65EPHB20.92595357
66MARK10.91703593
67MKNK20.91479034
68ILK0.90612282
69ROCK20.87950539
70BCR0.87509676
71CAMK1D0.86974467
72EPHA40.84397027
73PTK2B0.84077356
74PRKACA0.84068097
75MAPK150.81096359
76DYRK30.78871846
77NTRK10.78481203
78DYRK20.76171423
79FGFR20.75741603
80NTRK30.74989456
81MAP2K40.73705824
82CAMKK20.73530952
83CAMK1G0.73072092
84BMPR1B0.72438057
85PDK20.72269680
86BMPR20.71518374
87PLK20.70785986
88CDK190.69992521
89CSNK1G30.69984515
90ABL20.68998623
91CSNK1G20.68626757
92NEK20.68505976
93MAPK120.65259149
94CHEK20.64407128
95TIE10.63293124
96PRKAA20.59086692
97PLK40.58465504
98BUB10.57700015
99SGK4940.56410466
100SGK2230.56410466
101GRK60.55256710
102CDK50.54348545
103STK240.53793720
104CDC70.53628816
105NTRK20.53526003
106WNK10.53007305
107IRAK20.52261998
108RIPK40.52120454
109TLK10.50370380
110PRKD10.50102482
111CAMK10.50100802
112RPS6KA20.48093515
113CSNK1A1L0.47905537
114CSNK1A10.47729891
115MAP2K60.47561052
116ROCK10.47553484
117SGK20.47495419
118PRKAA10.45744607
119PRKCG0.45321414
120CHUK0.45279848
121PRKACG0.42944515
122PRKCQ0.42276490
123IKBKB0.41991322
124BRSK20.41696934
125MAP2K10.41398791
126MAPK40.40876405
127RPS6KL10.40519976
128RPS6KC10.40519976
129PRKCZ0.40403165
130PRKG10.40284228
131PRKACB0.39595671
132PRKCA0.39049045
133AURKA0.38118533
134PLK10.37874343
135VRK10.37865966
136CSNK1G10.37727790
137PIM20.35376619
138CDC42BPA0.35294606
139CAMK40.35046612
140PRKCI0.33646020
141ERBB20.33526022
142IRAK10.33331042
143CDK140.33277898
144EPHB10.33239827
145CSNK2A10.32809554
146MET0.30791711
147PIK3CG0.30518446

Predicted pathways (KEGG)

RankGene SetZ-score
1* Oxidative phosphorylation_Homo sapiens_hsa001906.35834893
2Parkinsons disease_Homo sapiens_hsa050125.43860862
3Alzheimers disease_Homo sapiens_hsa050104.22265704
4Huntingtons disease_Homo sapiens_hsa050163.62800130
5* Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.52227769
6Cardiac muscle contraction_Homo sapiens_hsa042603.44046446
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51701578
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49097360
9Sulfur metabolism_Homo sapiens_hsa009202.28537972
10Fatty acid elongation_Homo sapiens_hsa000622.26213032
11Ribosome_Homo sapiens_hsa030102.24666511
12Nitrogen metabolism_Homo sapiens_hsa009102.11019734
13Propanoate metabolism_Homo sapiens_hsa006401.98565879
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82100142
15Protein export_Homo sapiens_hsa030601.80624009
16Collecting duct acid secretion_Homo sapiens_hsa049661.74862014
17Selenocompound metabolism_Homo sapiens_hsa004501.72087178
18Butanoate metabolism_Homo sapiens_hsa006501.70660604
19Homologous recombination_Homo sapiens_hsa034401.70227158
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60651998
21Pyruvate metabolism_Homo sapiens_hsa006201.56046186
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.52866626
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42880724
24Proteasome_Homo sapiens_hsa030501.33279632
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30347512
26Basal transcription factors_Homo sapiens_hsa030221.26618780
27Fatty acid degradation_Homo sapiens_hsa000711.26365079
28Fanconi anemia pathway_Homo sapiens_hsa034601.19734422
29Fatty acid metabolism_Homo sapiens_hsa012121.17274631
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13797493
31Tyrosine metabolism_Homo sapiens_hsa003501.10268770
32Basal cell carcinoma_Homo sapiens_hsa052171.06562406
33Phenylalanine metabolism_Homo sapiens_hsa003601.04789816
34Vibrio cholerae infection_Homo sapiens_hsa051101.04329680
35Carbon metabolism_Homo sapiens_hsa012001.03223241
36One carbon pool by folate_Homo sapiens_hsa006701.01930426
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01685749
38Nicotine addiction_Homo sapiens_hsa050330.99552703
39Vitamin digestion and absorption_Homo sapiens_hsa049770.96289894
40Peroxisome_Homo sapiens_hsa041460.95544703
41RNA degradation_Homo sapiens_hsa030180.92678507
42Steroid biosynthesis_Homo sapiens_hsa001000.92373951
43* Metabolic pathways_Homo sapiens_hsa011000.86609507
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85022653
45Purine metabolism_Homo sapiens_hsa002300.84158338
46Serotonergic synapse_Homo sapiens_hsa047260.83874177
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83704985
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.83673325
49Dilated cardiomyopathy_Homo sapiens_hsa054140.79552277
50Retinol metabolism_Homo sapiens_hsa008300.79544406
51Taste transduction_Homo sapiens_hsa047420.79327624
52Synaptic vesicle cycle_Homo sapiens_hsa047210.78686722
53Histidine metabolism_Homo sapiens_hsa003400.78031279
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77520237
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77426626
56Caffeine metabolism_Homo sapiens_hsa002320.77337308
57Hedgehog signaling pathway_Homo sapiens_hsa043400.77336581
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77037574
59Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73389458
60Pyrimidine metabolism_Homo sapiens_hsa002400.72264460
61Tryptophan metabolism_Homo sapiens_hsa003800.71840605
62GABAergic synapse_Homo sapiens_hsa047270.68733953
63Linoleic acid metabolism_Homo sapiens_hsa005910.68295321
64Sulfur relay system_Homo sapiens_hsa041220.67148348
65Arginine and proline metabolism_Homo sapiens_hsa003300.66212866
66Ether lipid metabolism_Homo sapiens_hsa005650.66210042
67Ovarian steroidogenesis_Homo sapiens_hsa049130.64883501
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.64477845
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63002264
70beta-Alanine metabolism_Homo sapiens_hsa004100.62185974
71ABC transporters_Homo sapiens_hsa020100.61847707
72RNA polymerase_Homo sapiens_hsa030200.60083981
73Phototransduction_Homo sapiens_hsa047440.59453996
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58246859
75Rheumatoid arthritis_Homo sapiens_hsa053230.57454859
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.57026213
77PPAR signaling pathway_Homo sapiens_hsa033200.56536678
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.56244183
79Arachidonic acid metabolism_Homo sapiens_hsa005900.54278522
80Morphine addiction_Homo sapiens_hsa050320.54265845
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52615237
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50268474
83Mineral absorption_Homo sapiens_hsa049780.49467622
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49090311
85Glutathione metabolism_Homo sapiens_hsa004800.48988557
86Oxytocin signaling pathway_Homo sapiens_hsa049210.48628010
87Glutamatergic synapse_Homo sapiens_hsa047240.47390213
88Nucleotide excision repair_Homo sapiens_hsa034200.47170873
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45711706
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44635051
91Calcium signaling pathway_Homo sapiens_hsa040200.44450717
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43977293
93Insulin secretion_Homo sapiens_hsa049110.43922355
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.43338463
95Chemical carcinogenesis_Homo sapiens_hsa052040.42531928
96Cocaine addiction_Homo sapiens_hsa050300.42197252
97Circadian entrainment_Homo sapiens_hsa047130.41946173
98Circadian rhythm_Homo sapiens_hsa047100.41554207
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40575873
100Renin secretion_Homo sapiens_hsa049240.39858356
101cAMP signaling pathway_Homo sapiens_hsa040240.39810253
102Folate biosynthesis_Homo sapiens_hsa007900.39350898
103Dopaminergic synapse_Homo sapiens_hsa047280.38684293
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38266493
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.37018677
106Fat digestion and absorption_Homo sapiens_hsa049750.35182109
107Amphetamine addiction_Homo sapiens_hsa050310.35155307
108Cholinergic synapse_Homo sapiens_hsa047250.34956131
109Starch and sucrose metabolism_Homo sapiens_hsa005000.34188082
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33702884
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.32594696
112Salivary secretion_Homo sapiens_hsa049700.32233790
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32087273
114Pancreatic secretion_Homo sapiens_hsa049720.31323392
115Regulation of autophagy_Homo sapiens_hsa041400.30180880
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27452575
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26904637
118Fructose and mannose metabolism_Homo sapiens_hsa000510.25568577
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25104654
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24978322
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24130084
122Olfactory transduction_Homo sapiens_hsa047400.23796120
123Sphingolipid metabolism_Homo sapiens_hsa006000.22818839
124Gastric acid secretion_Homo sapiens_hsa049710.22266009
125Glycerolipid metabolism_Homo sapiens_hsa005610.21607921
126Phagosome_Homo sapiens_hsa041450.19957749
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.19242374
128Long-term depression_Homo sapiens_hsa047300.18171455
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16705835
130Galactose metabolism_Homo sapiens_hsa000520.15940718
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.15806310

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