NECAB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a neuronal calcium-binding protein that binds to and modulates the function of at least two receptors, adenosine A(2A) receptor and metabotropic glutamate receptor type 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.10907934
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.96691422
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.70577772
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.69325305
5locomotory exploration behavior (GO:0035641)5.61894377
6vocalization behavior (GO:0071625)5.17694181
7synaptic vesicle exocytosis (GO:0016079)5.10469799
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.90354855
9regulation of synapse structural plasticity (GO:0051823)4.86796916
10postsynaptic membrane organization (GO:0001941)4.83842800
11regulation of synaptic vesicle exocytosis (GO:2000300)4.81407855
12regulation of long-term neuronal synaptic plasticity (GO:0048169)4.77228669
13regulation of glutamate receptor signaling pathway (GO:1900449)4.75929640
14regulation of neuronal synaptic plasticity (GO:0048168)4.69935648
15neuronal ion channel clustering (GO:0045161)4.65512653
16protein localization to synapse (GO:0035418)4.65471577
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.57095604
18glutamate secretion (GO:0014047)4.53202478
19prepulse inhibition (GO:0060134)4.42918452
20neurotransmitter secretion (GO:0007269)4.42472524
21positive regulation of synaptic transmission, GABAergic (GO:0032230)4.41403890
22regulation of synaptic vesicle transport (GO:1902803)4.34730329
23dendritic spine morphogenesis (GO:0060997)4.25077421
24exploration behavior (GO:0035640)4.20112642
25adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.16275246
26neurotransmitter-gated ion channel clustering (GO:0072578)4.14420116
27synaptic transmission, dopaminergic (GO:0001963)4.13839401
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.12527156
29layer formation in cerebral cortex (GO:0021819)4.09950876
30neuronal action potential propagation (GO:0019227)4.09770776
31long-term memory (GO:0007616)4.08301667
32positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.03453898
33pyrimidine nucleobase catabolic process (GO:0006208)4.03226721
34striatum development (GO:0021756)4.01218314
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00580239
36neuron cell-cell adhesion (GO:0007158)3.99628829
37regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.97404644
38positive regulation of membrane potential (GO:0045838)3.94923039
39presynaptic membrane organization (GO:0097090)3.94070265
40positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.93303160
41regulation of dendritic spine morphogenesis (GO:0061001)3.91280704
42sodium ion export (GO:0071436)3.89885248
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.88480254
44synaptic transmission, glutamatergic (GO:0035249)3.87317234
45presynaptic membrane assembly (GO:0097105)3.85536294
46neuron-neuron synaptic transmission (GO:0007270)3.85535101
47auditory behavior (GO:0031223)3.82891264
48dopamine receptor signaling pathway (GO:0007212)3.81688254
49neuromuscular process controlling posture (GO:0050884)3.79915400
50neuromuscular process controlling balance (GO:0050885)3.76285805
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74818759
52activation of protein kinase A activity (GO:0034199)3.74583960
53gamma-aminobutyric acid transport (GO:0015812)3.74281617
54regulation of excitatory postsynaptic membrane potential (GO:0060079)3.72590198
55regulation of voltage-gated calcium channel activity (GO:1901385)3.71010587
56chemosensory behavior (GO:0007635)3.68889626
57regulation of glutamate secretion (GO:0014048)3.65087893
58response to auditory stimulus (GO:0010996)3.64189396
59L-amino acid import (GO:0043092)3.60187088
60regulation of synaptic plasticity (GO:0048167)3.59059343
61nucleobase catabolic process (GO:0046113)3.56850786
62behavioral response to cocaine (GO:0048148)3.56343280
63mating behavior (GO:0007617)3.54964968
64transmission of nerve impulse (GO:0019226)3.54725226
65positive regulation of neurotransmitter transport (GO:0051590)3.52267217
66neurotransmitter transport (GO:0006836)3.51605887
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.50743227
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.49758224
69regulation of postsynaptic membrane potential (GO:0060078)3.49620187
70adenosine receptor signaling pathway (GO:0001973)3.49424277
71glutamate receptor signaling pathway (GO:0007215)3.47798226
72regulation of female receptivity (GO:0045924)3.46504577
73negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.46271284
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.44467081
75G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.43684114
76response to amphetamine (GO:0001975)3.43338688
77axonal fasciculation (GO:0007413)3.42493753
78cerebellar granule cell differentiation (GO:0021707)3.39663614
79synaptic vesicle endocytosis (GO:0048488)3.38541414
80regulation of neurotransmitter levels (GO:0001505)3.37803562
81visual learning (GO:0008542)3.36877264
82glycine transport (GO:0015816)3.36771123
83neuromuscular synaptic transmission (GO:0007274)3.36018721
84positive regulation of dendritic spine morphogenesis (GO:0061003)3.35821985
85negative regulation of dendrite morphogenesis (GO:0050774)3.35363489
86long-term synaptic potentiation (GO:0060291)3.34301585
87regulation of vesicle fusion (GO:0031338)3.31784966
88behavioral fear response (GO:0001662)3.31757718
89behavioral defense response (GO:0002209)3.31757718
90positive regulation of neurotransmitter secretion (GO:0001956)3.29919622
91proline transport (GO:0015824)3.28975653
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28472266
93negative regulation of amino acid transport (GO:0051956)3.28143127
94cell migration in hindbrain (GO:0021535)3.25126642
95central nervous system myelination (GO:0022010)3.23378313
96axon ensheathment in central nervous system (GO:0032291)3.23378313
97negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21871282
98potassium ion import (GO:0010107)3.21275292
99visual behavior (GO:0007632)3.20718230
100regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.20355722
101regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.20355722
102learning (GO:0007612)3.20020411
103cell communication by electrical coupling (GO:0010644)3.19196510
104regulation of synaptic transmission, GABAergic (GO:0032228)3.19119979
105positive regulation of synapse maturation (GO:0090129)3.18729974
106regulation of neurotransmitter secretion (GO:0046928)3.15930983
107female mating behavior (GO:0060180)3.15419996
108regulation of neurotransmitter transport (GO:0051588)3.13050966
109positive regulation of dendritic spine development (GO:0060999)3.12817393
110neuron recognition (GO:0008038)3.12748570
111amino acid import (GO:0043090)3.12673288
112regulation of dendritic spine development (GO:0060998)3.11384312
113cellular potassium ion homeostasis (GO:0030007)3.09422607
114regulation of ARF protein signal transduction (GO:0032012)3.09002073
115detection of calcium ion (GO:0005513)3.08938616
116regulation of synaptic transmission (GO:0050804)3.08729725
117cerebellar Purkinje cell differentiation (GO:0021702)3.08356146
118adult walking behavior (GO:0007628)3.08003516
119positive regulation of synaptic transmission (GO:0050806)3.07393267
120dendritic spine organization (GO:0097061)3.07314987
121neuromuscular process (GO:0050905)3.06545873
122potassium ion homeostasis (GO:0055075)3.05222302
123response to histamine (GO:0034776)3.05038768
124regulation of synaptic transmission, dopaminergic (GO:0032225)3.04207952
125membrane hyperpolarization (GO:0060081)3.03179866
126membrane depolarization (GO:0051899)3.03080510
127establishment of mitochondrion localization (GO:0051654)3.02348612
128cerebellar Purkinje cell layer development (GO:0021680)3.00935306
129regulation of exocytosis (GO:0017157)3.00912597
130fear response (GO:0042596)3.00541383
131vesicle transport along microtubule (GO:0047496)2.99715156
132membrane depolarization during action potential (GO:0086010)2.99562645
133synaptic transmission (GO:0007268)2.96831476
134establishment of synaptic vesicle localization (GO:0097480)2.96764764
135synaptic vesicle transport (GO:0048489)2.96764764
136gamma-aminobutyric acid signaling pathway (GO:0007214)2.94776090
137cellular sodium ion homeostasis (GO:0006883)2.93104192
138phosphorelay signal transduction system (GO:0000160)2.87925243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94128956
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.34392695
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12043780
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01988354
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01778855
6GBX2_23144817_ChIP-Seq_PC3_Human3.01642758
7REST_21632747_ChIP-Seq_MESCs_Mouse2.93018601
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.78656974
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70366089
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70366089
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.67345093
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63453664
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.58898080
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.56653932
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54897117
16DROSHA_22980978_ChIP-Seq_HELA_Human2.54884699
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.54687953
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53338200
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51383741
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41680513
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.39953690
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.36857359
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.31870637
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31623945
25* RNF2_27304074_Chip-Seq_ESCs_Mouse2.22067505
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20742899
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18709144
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.07605188
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06808507
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.84820586
31AR_21572438_ChIP-Seq_LNCaP_Human1.76668443
32RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.62370477
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57492389
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50718181
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49327365
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46646553
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42120462
38SMAD4_21799915_ChIP-Seq_A2780_Human1.41715936
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.38940267
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33597232
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33301710
42EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31542702
43KDM2B_26808549_Chip-Seq_K562_Human1.30724470
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28393197
45CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27138681
46* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26803407
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25895792
48SOX2_21211035_ChIP-Seq_LN229_Gbm1.25739737
49AR_19668381_ChIP-Seq_PC3_Human1.24012227
50TAF15_26573619_Chip-Seq_HEK293_Human1.22160160
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.20341145
52ZNF274_21170338_ChIP-Seq_K562_Hela1.14288554
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13199352
54CTCF_27219007_Chip-Seq_Bcells_Human1.12670683
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12416619
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12280431
57STAT3_23295773_ChIP-Seq_U87_Human1.12161550
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.12022191
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11262764
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10584692
61PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10267687
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10243396
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07674651
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06832330
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.06765030
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06354929
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06354929
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06112670
69SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05640307
70AR_25329375_ChIP-Seq_VCAP_Human1.04827278
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03906462
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03587214
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.02948964
74P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01627321
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00125657
76YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98837379
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97903137
78P300_19829295_ChIP-Seq_ESCs_Human0.97855020
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97463858
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97171685
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97007561
82SMAD3_21741376_ChIP-Seq_ESCs_Human0.96325292
83TET1_21490601_ChIP-Seq_MESCs_Mouse0.96288952
84DPY_21335234_ChIP-Seq_ESCs_Mouse0.94482626
85* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94374435
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93655814
87OCT4_19829295_ChIP-Seq_ESCs_Human0.93039830
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93021981
89RNF2_27304074_Chip-Seq_NSC_Mouse0.92922211
90TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92735428
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91369853
92SMAD3_21741376_ChIP-Seq_HESCs_Human0.90185937
93ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90164768
94TCF4_23295773_ChIP-Seq_U87_Human0.89930697
95NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89752410
96* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89625393
97* KLF4_19829295_ChIP-Seq_ESCs_Human0.88212258
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.87996609
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.87335316
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.86382877
101ZFP57_27257070_Chip-Seq_ESCs_Mouse0.86267658
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.85405834
103RUNX2_22187159_ChIP-Seq_PCA_Human0.84468542
104GATA1_26923725_Chip-Seq_HPCs_Mouse0.84170074
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82950258
106* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82570923
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82387723
108PIAS1_25552417_ChIP-Seq_VCAP_Human0.81322940
109LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80757817
110CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80300943
111AHR_22903824_ChIP-Seq_MCF-7_Human0.80052055
112SMAD_19615063_ChIP-ChIP_OVARY_Human0.79708458
113SMAD4_21741376_ChIP-Seq_EPCs_Human0.78463866
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78271881
115SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77800065
116LXR_22292898_ChIP-Seq_THP-1_Human0.77742074
117EGR1_19032775_ChIP-ChIP_M12_Human0.75789010
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74852298
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.74246619
120POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.70069295
121ETV2_25802403_ChIP-Seq_MESCs_Mouse0.68799780
122SMC4_20622854_ChIP-Seq_HELA_Human0.68769201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.18502582
2MP0002822_catalepsy5.56902795
3MP0003880_abnormal_central_pattern4.47847265
4MP0003635_abnormal_synaptic_transmissio4.06911398
5MP0004270_analgesia3.52008059
6MP0002063_abnormal_learning/memory/cond3.41873523
7MP0009745_abnormal_behavioral_response3.38580764
8MP0000013_abnormal_adipose_tissue2.96717782
9MP0002064_seizures2.95164437
10MP0002572_abnormal_emotion/affect_behav2.88828275
11MP0005423_abnormal_somatic_nervous2.61278886
12MP0009046_muscle_twitch2.57819106
13MP0001968_abnormal_touch/_nociception2.57754144
14MP0001486_abnormal_startle_reflex2.52525914
15MP0002272_abnormal_nervous_system2.49661023
16MP0002734_abnormal_mechanical_nocicepti2.34468598
17MP0002909_abnormal_adrenal_gland2.21227622
18MP0001501_abnormal_sleep_pattern2.20792462
19MP0002733_abnormal_thermal_nociception2.05161230
20MP0005646_abnormal_pituitary_gland1.98800971
21MP0001529_abnormal_vocalization1.92690659
22MP0001970_abnormal_pain_threshold1.89884326
23MP0001440_abnormal_grooming_behavior1.82864162
24MP0003879_abnormal_hair_cell1.79770465
25MP0002735_abnormal_chemical_nociception1.75898358
26MP0009780_abnormal_chondrocyte_physiolo1.74155370
27MP0006276_abnormal_autonomic_nervous1.72925034
28MP0002557_abnormal_social/conspecific_i1.72506924
29MP0002067_abnormal_sensory_capabilities1.71275495
30MP0005645_abnormal_hypothalamus_physiol1.70954678
31MP0004811_abnormal_neuron_physiology1.69921180
32MP0005386_behavior/neurological_phenoty1.69323659
33MP0004924_abnormal_behavior1.69323659
34MP0002736_abnormal_nociception_after1.68622801
35MP0001984_abnormal_olfaction1.65289286
36MP0003122_maternal_imprinting1.61520282
37MP0002184_abnormal_innervation1.59108818
38MP0003787_abnormal_imprinting1.51568454
39MP0008569_lethality_at_weaning1.50358490
40MP0004858_abnormal_nervous_system1.49614835
41MP0000955_abnormal_spinal_cord1.48743008
42MP0003329_amyloid_beta_deposits1.43679837
43MP0000778_abnormal_nervous_system1.41341272
44MP0003283_abnormal_digestive_organ1.40902129
45MP0004885_abnormal_endolymph1.39831876
46MP0001502_abnormal_circadian_rhythm1.36990590
47MP0002066_abnormal_motor_capabilities/c1.35765252
48MP0002882_abnormal_neuron_morphology1.35697997
49MP0001905_abnormal_dopamine_level1.27412839
50MP0000003_abnormal_adipose_tissue1.22756570
51MP0003633_abnormal_nervous_system1.18480197
52MP0008961_abnormal_basal_metabolism1.13514828
53MP0002152_abnormal_brain_morphology1.05557413
54MP0000566_synostosis1.00466620
55MP0003938_abnormal_ear_development0.99421124
56MP0004142_abnormal_muscle_tone0.99014283
57MP0002069_abnormal_eating/drinking_beha0.98766181
58MP0002229_neurodegeneration0.98116928
59MP0001485_abnormal_pinna_reflex0.97464521
60MP0000751_myopathy0.96823015
61MP0003631_nervous_system_phenotype0.96817259
62MP0001188_hyperpigmentation0.95826015
63MP0003075_altered_response_to0.94703925
64MP0005535_abnormal_body_temperature0.92443464
65MP0005551_abnormal_eye_electrophysiolog0.91936397
66MP0005499_abnormal_olfactory_system0.91296393
67MP0005394_taste/olfaction_phenotype0.91296393
68MP0000631_abnormal_neuroendocrine_gland0.91076086
69MP0005167_abnormal_blood-brain_barrier0.88972712
70MP0010386_abnormal_urinary_bladder0.88417747
71MP0003123_paternal_imprinting0.88068138
72MP0001177_atelectasis0.87789515
73MP0008872_abnormal_physiological_respon0.87311049
74MP0004085_abnormal_heartbeat0.85570624
75MP0002638_abnormal_pupillary_reflex0.85092340
76MP0002876_abnormal_thyroid_physiology0.84935721
77MP0008874_decreased_physiological_sensi0.84508870
78MP0004742_abnormal_vestibular_system0.84211498
79MP0010234_abnormal_vibrissa_follicle0.81266573
80MP0000569_abnormal_digit_pigmentation0.81052042
81MP0003136_yellow_coat_color0.80326939
82MP0003011_delayed_dark_adaptation0.79786393
83MP0008877_abnormal_DNA_methylation0.79734822
84MP0000026_abnormal_inner_ear0.77778619
85MP0001346_abnormal_lacrimal_gland0.75961833
86MP0003634_abnormal_glial_cell0.73580238
87MP0002102_abnormal_ear_morphology0.73505452
88MP0002090_abnormal_vision0.67352256
89MP0000639_abnormal_adrenal_gland0.67156038
90MP0002752_abnormal_somatic_nervous0.66903034
91MP0003690_abnormal_glial_cell0.65104653
92MP0001963_abnormal_hearing_physiology0.65068534
93MP0005248_abnormal_Harderian_gland0.64919510
94MP0005409_darkened_coat_color0.64743616
95MP0003878_abnormal_ear_physiology0.64728326
96MP0005377_hearing/vestibular/ear_phenot0.64728326
97MP0001986_abnormal_taste_sensitivity0.64255614
98MP0002837_dystrophic_cardiac_calcinosis0.63985144
99MP0002928_abnormal_bile_duct0.62907065
100MP0003121_genomic_imprinting0.62892430
101MP0002653_abnormal_ependyma_morphology0.62221334
102MP0003137_abnormal_impulse_conducting0.62059552
103MP0004133_heterotaxia0.59913896
104MP0004043_abnormal_pH_regulation0.59652972
105MP0003632_abnormal_nervous_system0.58406068
106MP0004145_abnormal_muscle_electrophysio0.57128497
107MP0004233_abnormal_muscle_weight0.56693340
108MP0006292_abnormal_olfactory_placode0.56411376
109MP0006072_abnormal_retinal_apoptosis0.54768671
110MP0010769_abnormal_survival0.53545525
111MP0010770_preweaning_lethality0.53299969
112MP0002082_postnatal_lethality0.53299969
113MP0001943_abnormal_respiration0.52769754
114MP0003172_abnormal_lysosome_physiology0.52223878
115MP0003861_abnormal_nervous_system0.50875099
116MP0003956_abnormal_body_size0.50017542
117MP0000604_amyloidosis0.49274383
118MP0000920_abnormal_myelination0.48212616

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.03326113
2Focal motor seizures (HP:0011153)6.90862301
3Focal seizures (HP:0007359)5.27569677
4Visual hallucinations (HP:0002367)5.09387953
5Abnormality of binocular vision (HP:0011514)3.79975250
6Diplopia (HP:0000651)3.79975250
7Poor eye contact (HP:0000817)3.77986942
8Epileptic encephalopathy (HP:0200134)3.70710704
9Febrile seizures (HP:0002373)3.68752948
10Ankle clonus (HP:0011448)3.65412684
11Absence seizures (HP:0002121)3.60769665
12Atonic seizures (HP:0010819)3.58965240
13Anxiety (HP:0000739)3.49506021
14Torticollis (HP:0000473)3.48540704
15Generalized tonic-clonic seizures (HP:0002069)3.45963526
16Depression (HP:0000716)3.45381936
17Progressive cerebellar ataxia (HP:0002073)3.45331755
18Action tremor (HP:0002345)3.43943982
19Impaired social interactions (HP:0000735)3.42014494
20Abnormal social behavior (HP:0012433)3.42014494
21Impaired vibration sensation in the lower limbs (HP:0002166)3.30964405
22Annular pancreas (HP:0001734)3.30644169
23Dialeptic seizures (HP:0011146)3.27204771
24Supranuclear gaze palsy (HP:0000605)3.17698918
25Focal dystonia (HP:0004373)3.13795075
26Megalencephaly (HP:0001355)3.09033518
27Limb dystonia (HP:0002451)3.02800889
28Urinary bladder sphincter dysfunction (HP:0002839)3.00608524
29Abnormal eating behavior (HP:0100738)3.00500292
30Dysdiadochokinesis (HP:0002075)3.00480751
31Broad-based gait (HP:0002136)3.00062708
32Papilledema (HP:0001085)2.99468596
33Postural instability (HP:0002172)2.96399814
34Oligodactyly (hands) (HP:0001180)2.95543141
35Craniofacial dystonia (HP:0012179)2.92681283
36Sleep apnea (HP:0010535)2.87580383
37Resting tremor (HP:0002322)2.85324150
38Failure to thrive in infancy (HP:0001531)2.84027331
39Gaze-evoked nystagmus (HP:0000640)2.78265486
40Truncal ataxia (HP:0002078)2.78022654
41Akinesia (HP:0002304)2.72552209
42Stereotypic behavior (HP:0000733)2.72056856
43Dysmetria (HP:0001310)2.70961512
44Mutism (HP:0002300)2.69101744
45Abnormality of the corticospinal tract (HP:0002492)2.69094740
46Split foot (HP:0001839)2.62405096
47Increased circulating renin level (HP:0000848)2.58318175
48Urinary urgency (HP:0000012)2.58196701
49Scanning speech (HP:0002168)2.52133663
50EEG with generalized epileptiform discharges (HP:0011198)2.47587893
51Epileptiform EEG discharges (HP:0011182)2.46480622
52Hypsarrhythmia (HP:0002521)2.46169457
53Peripheral hypomyelination (HP:0007182)2.44706244
54Pointed chin (HP:0000307)2.44700658
55Bradykinesia (HP:0002067)2.43029065
56Progressive inability to walk (HP:0002505)2.42611386
57Ventricular fibrillation (HP:0001663)2.40449977
58Abnormality of the lower motor neuron (HP:0002366)2.40366332
59Delusions (HP:0000746)2.38546923
60Spastic gait (HP:0002064)2.36711296
61Amblyopia (HP:0000646)2.36364364
62Anomalous pulmonary venous return (HP:0010772)2.33343407
63Impaired smooth pursuit (HP:0007772)2.30499005
64Tetraplegia (HP:0002445)2.26868786
65Neuronal loss in central nervous system (HP:0002529)2.26257058
66Hemiparesis (HP:0001269)2.24582299
67Genetic anticipation (HP:0003743)2.23789576
68Cerebral inclusion bodies (HP:0100314)2.23382811
69Poor suck (HP:0002033)2.22590781
70Polyphagia (HP:0002591)2.19811878
71Congenital malformation of the right heart (HP:0011723)2.19192688
72Double outlet right ventricle (HP:0001719)2.19192688
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18883117
74Intention tremor (HP:0002080)2.17539219
75Oligodactyly (HP:0012165)2.17260380
76Degeneration of the lateral corticospinal tracts (HP:0002314)2.17109567
77Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.17109567
78Morphological abnormality of the pyramidal tract (HP:0002062)2.16650819
79Deep palmar crease (HP:0006191)2.16555787
80Ankyloglossia (HP:0010296)2.16218220
81Hyperventilation (HP:0002883)2.11633867
82Abnormal EKG (HP:0003115)2.10137481
83Impaired vibratory sensation (HP:0002495)2.07181902
84Nuclear cataract (HP:0100018)2.05502065
85Neurofibrillary tangles (HP:0002185)2.05341370
86Clonus (HP:0002169)2.05310640
87Insomnia (HP:0100785)2.04756532
88Fetal akinesia sequence (HP:0001989)2.04603485
89Lower limb muscle weakness (HP:0007340)2.03867577
90Agitation (HP:0000713)2.03107657
91Amyotrophic lateral sclerosis (HP:0007354)2.02925378
92Excessive salivation (HP:0003781)2.02355316
93Drooling (HP:0002307)2.02355316
94Insidious onset (HP:0003587)2.01398261
95Termporal pattern (HP:0011008)2.01398261
96Dysmetric saccades (HP:0000641)2.00194540
97Abnormality of the aortic arch (HP:0012303)1.99488269
98Prolonged QT interval (HP:0001657)1.98160546
99Cerebral hypomyelination (HP:0006808)1.98088941
100Lower limb asymmetry (HP:0100559)1.97721624
101Abnormality of ocular smooth pursuit (HP:0000617)1.97279156
102Abnormality of the labia minora (HP:0012880)1.95800073
103Obstructive sleep apnea (HP:0002870)1.95668111
104Spastic tetraparesis (HP:0001285)1.95216853
105Hemiplegia (HP:0002301)1.93427554
106Lower limb amyotrophy (HP:0007210)1.90823469
107Abnormality of the pulmonary veins (HP:0011718)1.90655295
108Gait imbalance (HP:0002141)1.89434476
109Pheochromocytoma (HP:0002666)1.89344717
110Male infertility (HP:0003251)1.87009319
111Bundle branch block (HP:0011710)1.85329817
112Status epilepticus (HP:0002133)1.84898218
113Spastic tetraplegia (HP:0002510)1.82192312
114Apathy (HP:0000741)1.81384282
115Generalized myoclonic seizures (HP:0002123)1.80938985
116Incomplete penetrance (HP:0003829)1.80631868
117Absent speech (HP:0001344)1.78715063
118Choreoathetosis (HP:0001266)1.78529054
119Psychosis (HP:0000709)1.78468763
120Bronchomalacia (HP:0002780)1.78143409
121Fragile nails (HP:0001808)1.77888099
122Generalized hypotonia (HP:0001290)1.75863497
123Aplasia involving bones of the upper limbs (HP:0009823)1.74869911
124Aplasia of the phalanges of the hand (HP:0009802)1.74869911
125Aplasia involving bones of the extremities (HP:0009825)1.74869911
126Diminished motivation (HP:0000745)1.74705807
127Inability to walk (HP:0002540)1.74287583
128Anosmia (HP:0000458)1.71899103
129Truncus arteriosus (HP:0001660)1.71324591
130Gait ataxia (HP:0002066)1.69981276
131Death in childhood (HP:0003819)1.69453064
132Hypercortisolism (HP:0001578)1.68816900
133Deeply set eye (HP:0000490)1.68709727
134Menstrual irregularities (HP:0000858)1.68580570
135Specific learning disability (HP:0001328)1.67440255
136Rigidity (HP:0002063)1.67391400
137Thickened helices (HP:0000391)1.67389091
138Mixed hearing impairment (HP:0000410)1.64957135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.35587468
2NTRK34.62414239
3MAP3K94.07145571
4PRKD32.93940894
5KSR22.69118574
6MINK12.57583697
7TAOK12.44320354
8ARAF2.42945229
9MARK12.39560933
10MAP3K42.34827966
11DAPK22.18851605
12NTRK22.03984630
13PAK61.97015552
14CAMKK11.93245162
15KSR11.91646723
16NTRK11.86971059
17MAP2K71.79634642
18RIPK41.59278794
19TNIK1.57778462
20CDK51.56254076
21BRAF1.55541798
22PINK11.54859936
23MAP3K121.48100095
24MAP3K21.45718951
25DYRK21.44790598
26MAP2K41.43277941
27MAP3K131.41548477
28TYRO31.37315754
29FES1.36588987
30STK381.33090054
31GRK51.22946930
32RAF11.22131739
33UHMK11.21649364
34DAPK11.21548269
35PRPF4B1.15315906
36MAPK131.10940915
37SIK21.08303556
38PRKCH1.03751286
39CAMKK21.02466073
40IRAK20.99841270
41PRKCG0.98838013
42SGK4940.98766484
43SGK2230.98766484
44CDK140.94595960
45CDK180.93317625
46FGFR20.90451897
47CAMK2A0.90273532
48CDK150.89491241
49PLK20.88981369
50MAP3K110.87744594
51MAP3K10.86818048
52RIPK10.86622462
53ALK0.85263228
54MAP2K60.83561704
55LATS20.83504832
56STK110.83365913
57PNCK0.82081239
58CASK0.80951421
59SGK20.78148660
60CDK11A0.77916389
61PHKG20.75046194
62PHKG10.75046194
63SGK10.73142633
64RET0.72987768
65TNK20.72023869
66CAMK10.70683338
67OXSR10.70636640
68CAMK2B0.69453326
69NEK10.69037892
70BMPR20.68467882
71MARK20.68289615
72PAK30.66931172
73CDK190.66405764
74PDPK10.65989404
75MAPK120.65609115
76SGK30.65204720
77PDK10.64105358
78LMTK20.60504677
79WNK30.59377993
80PKN10.56932778
81DYRK1A0.55398366
82DMPK0.55065875
83PRKD20.54930520
84CDC42BPA0.54813095
85CSNK1G20.51359183
86RPS6KA30.50686829
87SCYL20.49341911
88NEK60.49125384
89ERBB20.48693775
90BRSK10.48228772
91PRKCZ0.46831154
92PTK2B0.46677745
93MAP2K10.45654905
94MAPK100.45611004
95CAMK2G0.44789697
96DAPK30.44361177
97RPS6KA20.43664164
98CAMK2D0.41945089
99SIK30.40353625
100LIMK10.39108219
101PRKG20.38463944
102CAMK40.35927012
103PRKCE0.35551113
104FYN0.34749332
105ROCK20.34427777
106EPHB20.33978976
107MOS0.33909520
108CAMK1G0.33726263
109DYRK1B0.33209202
110HIPK20.30829101
111PRKACA0.30739814
112PRKCB0.30441267
113PRKG10.29689036
114MUSK0.27967544
115MAP4K20.27876637
116MAP3K60.27412288
117MAPK80.27183091
118PDGFRA0.26994387
119FER0.26967248
120INSRR0.26652658
121MAPK150.26163706
122CSNK1G30.25785229

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.25918742
2Synaptic vesicle cycle_Homo sapiens_hsa047213.22474184
3Nicotine addiction_Homo sapiens_hsa050333.06610926
4GABAergic synapse_Homo sapiens_hsa047272.87528868
5Morphine addiction_Homo sapiens_hsa050322.71139157
6Circadian entrainment_Homo sapiens_hsa047132.67327644
7Amphetamine addiction_Homo sapiens_hsa050312.63844839
8Long-term potentiation_Homo sapiens_hsa047202.59957234
9Glutamatergic synapse_Homo sapiens_hsa047242.44691821
10Dopaminergic synapse_Homo sapiens_hsa047282.43975015
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.43442234
12Cocaine addiction_Homo sapiens_hsa050302.35579865
13Insulin secretion_Homo sapiens_hsa049112.19981036
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18849613
15Cholinergic synapse_Homo sapiens_hsa047252.15765206
16Salivary secretion_Homo sapiens_hsa049701.91651743
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86879507
18Serotonergic synapse_Homo sapiens_hsa047261.73689352
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72988394
20Gastric acid secretion_Homo sapiens_hsa049711.72713971
21Vitamin B6 metabolism_Homo sapiens_hsa007501.67234828
22Renin secretion_Homo sapiens_hsa049241.66414725
23Oxytocin signaling pathway_Homo sapiens_hsa049211.64688492
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63342175
25Taste transduction_Homo sapiens_hsa047421.62952590
26Long-term depression_Homo sapiens_hsa047301.57706346
27Gap junction_Homo sapiens_hsa045401.51324030
28GnRH signaling pathway_Homo sapiens_hsa049121.46955238
29Calcium signaling pathway_Homo sapiens_hsa040201.45635823
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34455498
31cAMP signaling pathway_Homo sapiens_hsa040241.33007001
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28334325
33Type II diabetes mellitus_Homo sapiens_hsa049301.27643354
34Collecting duct acid secretion_Homo sapiens_hsa049661.27214098
35Glioma_Homo sapiens_hsa052141.23639789
36Estrogen signaling pathway_Homo sapiens_hsa049151.21849651
37Nitrogen metabolism_Homo sapiens_hsa009101.18534877
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14124987
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09913107
40Melanogenesis_Homo sapiens_hsa049161.05503863
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04316551
42Oocyte meiosis_Homo sapiens_hsa041141.02995483
43ErbB signaling pathway_Homo sapiens_hsa040120.99789173
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.98848327
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97114004
46Type I diabetes mellitus_Homo sapiens_hsa049400.95597584
47Axon guidance_Homo sapiens_hsa043600.92295912
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92013679
49Phototransduction_Homo sapiens_hsa047440.90922380
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.89786833
51Oxidative phosphorylation_Homo sapiens_hsa001900.87990629
52Vibrio cholerae infection_Homo sapiens_hsa051100.87089451
53Alcoholism_Homo sapiens_hsa050340.86350754
54Cardiac muscle contraction_Homo sapiens_hsa042600.84924973
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80197204
56Thyroid hormone synthesis_Homo sapiens_hsa049180.78544446
57Alzheimers disease_Homo sapiens_hsa050100.78418196
58Non-small cell lung cancer_Homo sapiens_hsa052230.75292378
59Choline metabolism in cancer_Homo sapiens_hsa052310.73304110
60Dorso-ventral axis formation_Homo sapiens_hsa043200.73182035
61Parkinsons disease_Homo sapiens_hsa050120.73151383
62VEGF signaling pathway_Homo sapiens_hsa043700.71720458
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.71451864
64Pancreatic secretion_Homo sapiens_hsa049720.70771541
65Prion diseases_Homo sapiens_hsa050200.70552867
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70137410
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67386898
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66284528
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66146918
70Endometrial cancer_Homo sapiens_hsa052130.66083506
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65628551
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65030940
73Dilated cardiomyopathy_Homo sapiens_hsa054140.64932841
74Glucagon signaling pathway_Homo sapiens_hsa049220.61378895
75MAPK signaling pathway_Homo sapiens_hsa040100.60997863
76Rap1 signaling pathway_Homo sapiens_hsa040150.60892156
77Ras signaling pathway_Homo sapiens_hsa040140.60077123
78mTOR signaling pathway_Homo sapiens_hsa041500.59525646
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56970496
80Butanoate metabolism_Homo sapiens_hsa006500.56149753
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54753305
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.53289675
83Renal cell carcinoma_Homo sapiens_hsa052110.52433461
84Inositol phosphate metabolism_Homo sapiens_hsa005620.51828189
85Arginine biosynthesis_Homo sapiens_hsa002200.49782029
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49467271
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49260849
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49154710
89Insulin signaling pathway_Homo sapiens_hsa049100.48613311
90Regulation of autophagy_Homo sapiens_hsa041400.48230152
91Circadian rhythm_Homo sapiens_hsa047100.47818527
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45222464
93Bile secretion_Homo sapiens_hsa049760.43753389
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42126345
95Endocytosis_Homo sapiens_hsa041440.42033168
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41168132
97Ovarian steroidogenesis_Homo sapiens_hsa049130.40257715
98Hippo signaling pathway_Homo sapiens_hsa043900.39080528
99Chemokine signaling pathway_Homo sapiens_hsa040620.37811017
100Thyroid cancer_Homo sapiens_hsa052160.37252341
101Hedgehog signaling pathway_Homo sapiens_hsa043400.36934446
102Maturity onset diabetes of the young_Homo sapiens_hsa049500.33989769
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33526443
104Wnt signaling pathway_Homo sapiens_hsa043100.33429661
105Prolactin signaling pathway_Homo sapiens_hsa049170.32945800
106Huntingtons disease_Homo sapiens_hsa050160.29409252
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29380406
108AMPK signaling pathway_Homo sapiens_hsa041520.27722606
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27693095
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.27007346
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26695756
112Colorectal cancer_Homo sapiens_hsa052100.26440176
113Folate biosynthesis_Homo sapiens_hsa007900.25527254
114Arginine and proline metabolism_Homo sapiens_hsa003300.25135454
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.24930142
116Histidine metabolism_Homo sapiens_hsa003400.24875016
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24776655
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22723640

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