NECAB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)6.25499064
2glutamate secretion (GO:0014047)6.18524784
3synaptic vesicle exocytosis (GO:0016079)6.13744104
4synaptic vesicle maturation (GO:0016188)5.89150796
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78612843
6regulation of synaptic vesicle exocytosis (GO:2000300)5.49396773
7negative regulation of dendrite morphogenesis (GO:0050774)5.44675992
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.07417371
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89277487
10regulation of synaptic vesicle transport (GO:1902803)4.84249111
11locomotory exploration behavior (GO:0035641)4.72869237
12vocalization behavior (GO:0071625)4.61679538
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.60849892
14protein localization to synapse (GO:0035418)4.57775835
15neuron cell-cell adhesion (GO:0007158)4.42646815
16cell migration in hindbrain (GO:0021535)4.36826697
17cerebellar Purkinje cell differentiation (GO:0021702)4.31233378
18neurotransmitter secretion (GO:0007269)4.29857857
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.26191193
20negative regulation of dendrite development (GO:2000171)4.12106786
21regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.09947672
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01472203
23proline biosynthetic process (GO:0006561)4.00452680
24regulation of glutamate receptor signaling pathway (GO:1900449)3.99834499
25neuromuscular process controlling posture (GO:0050884)3.99693871
26membrane depolarization during action potential (GO:0086010)3.96595347
27proline transport (GO:0015824)3.95627732
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.93505990
29exploration behavior (GO:0035640)3.92712549
30regulation of neuronal synaptic plasticity (GO:0048168)3.89644249
31NADH metabolic process (GO:0006734)3.85778510
32neuron-neuron synaptic transmission (GO:0007270)3.79975802
33synaptic transmission, glutamatergic (GO:0035249)3.79133276
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.77974842
35neurofilament cytoskeleton organization (GO:0060052)3.77339136
36creatine metabolic process (GO:0006600)3.70412776
37positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.68850580
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63964693
39proline metabolic process (GO:0006560)3.63653862
40cellular potassium ion homeostasis (GO:0030007)3.61581523
41innervation (GO:0060384)3.59912030
42regulation of neurotransmitter secretion (GO:0046928)3.58246688
43regulation of cholesterol biosynthetic process (GO:0045540)3.58150214
44muscle filament sliding (GO:0030049)3.57264597
45actin-myosin filament sliding (GO:0033275)3.57264597
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51433735
47neurotransmitter transport (GO:0006836)3.49174929
48gamma-aminobutyric acid transport (GO:0015812)3.45221199
49negative regulation of cell size (GO:0045792)3.44199553
50glutamate receptor signaling pathway (GO:0007215)3.42954978
51calcium-mediated signaling using intracellular calcium source (GO:0035584)3.42124462
52gluconeogenesis (GO:0006094)3.40336647
53regulation of synaptic plasticity (GO:0048167)3.40036358
54calcium ion-dependent exocytosis (GO:0017156)3.37605747
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37020680
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35878508
57activation of protein kinase A activity (GO:0034199)3.33597041
58synaptic vesicle endocytosis (GO:0048488)3.31897806
59neurotransmitter-gated ion channel clustering (GO:0072578)3.30424567
60response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.29426223
61regulation of neurotransmitter levels (GO:0001505)3.27786071
62regulation of synapse structural plasticity (GO:0051823)3.27231130
63Golgi transport vesicle coating (GO:0048200)3.26993928
64COPI coating of Golgi vesicle (GO:0048205)3.26993928
65L-phenylalanine metabolic process (GO:0006558)3.25597490
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.25597490
67negative regulation of microtubule polymerization (GO:0031115)3.25083395
68membrane depolarization (GO:0051899)3.24649758
69hexose biosynthetic process (GO:0019319)3.23308413
70cell-substrate adherens junction assembly (GO:0007045)3.22770078
71focal adhesion assembly (GO:0048041)3.22770078
72long-term synaptic potentiation (GO:0060291)3.21297579
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20765387
74regulation of postsynaptic membrane potential (GO:0060078)3.20671431
75protein retention in ER lumen (GO:0006621)3.19499191
76positive regulation of membrane potential (GO:0045838)3.19217576
77regulation of neurotransmitter transport (GO:0051588)3.19071657
78retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.16340542
79negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16097374
80neuronal action potential (GO:0019228)3.15853245
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.15766321
82adherens junction assembly (GO:0034333)3.15711062
83regulation of vesicle fusion (GO:0031338)3.14701451
84cell communication by electrical coupling (GO:0010644)3.13588000
85regulation of sodium ion transmembrane transporter activity (GO:2000649)3.13291345
86sodium ion export (GO:0071436)3.11240651
87cardiac muscle contraction (GO:0060048)3.10068109
88cytoskeletal anchoring at plasma membrane (GO:0007016)3.06340255
89synaptic transmission (GO:0007268)3.05856339
90neuromuscular process (GO:0050905)3.04435919
91monosaccharide biosynthetic process (GO:0046364)3.04273176
92neuromuscular process controlling balance (GO:0050885)3.04069144
93positive regulation of potassium ion transmembrane transport (GO:1901381)3.03655884
94vesicle transport along microtubule (GO:0047496)3.03505168
95negative regulation of cation channel activity (GO:2001258)3.03018796
96detection of temperature stimulus involved in sensory perception (GO:0050961)3.02782988
97detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.02782988
984-hydroxyproline metabolic process (GO:0019471)3.00766459
99peripheral nervous system neuron development (GO:0048935)3.00174238
100regulation of voltage-gated calcium channel activity (GO:1901385)2.99878238
101membrane repolarization (GO:0086009)2.99539131
102neuron recognition (GO:0008038)2.99460107
103synaptic vesicle transport (GO:0048489)2.98675477
104establishment of synaptic vesicle localization (GO:0097480)2.98675477
105layer formation in cerebral cortex (GO:0021819)2.98446275
106urea cycle (GO:0000050)2.97614686
107peptidyl-glutamic acid carboxylation (GO:0017187)2.97496303
108protein carboxylation (GO:0018214)2.97496303
109mating behavior (GO:0007617)2.95848768
110oxaloacetate metabolic process (GO:0006107)2.95665313
111neuromuscular synaptic transmission (GO:0007274)2.94920421
112positive regulation of synapse maturation (GO:0090129)2.94673203
113sarcomere organization (GO:0045214)2.93859630
114ATP hydrolysis coupled proton transport (GO:0015991)2.93093544
115energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.93093544
116transferrin transport (GO:0033572)2.92935063
117negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92361804
118presynaptic membrane assembly (GO:0097105)2.89824127
119regulation of synaptic transmission (GO:0050804)2.89753902
120presynaptic membrane organization (GO:0097090)2.89245015
121membrane hyperpolarization (GO:0060081)2.89161795
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.89082151
123organelle transport along microtubule (GO:0072384)2.88531891
124regulation of synaptic transmission, glutamatergic (GO:0051966)2.88302671
125detection of temperature stimulus (GO:0016048)2.88124695
126regulation of cholesterol metabolic process (GO:0090181)2.87161727
127regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.86931567
128inositol phosphate catabolic process (GO:0071545)2.85838991
129adult walking behavior (GO:0007628)2.85165840
130synapse assembly (GO:0007416)2.85061142
1312-oxoglutarate metabolic process (GO:0006103)2.84963802
132establishment of vesicle localization (GO:0051650)2.84462211
133striated muscle contraction (GO:0006941)2.84236704
134sarcoplasmic reticulum calcium ion transport (GO:0070296)2.82287319
135cardiac myofibril assembly (GO:0055003)2.78901594
136urea metabolic process (GO:0019627)2.75475188
137actin-mediated cell contraction (GO:0070252)2.75315867
138biotin metabolic process (GO:0006768)2.75214020
139L-phenylalanine catabolic process (GO:0006559)2.70379836
140erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.70379836
141skeletal muscle contraction (GO:0003009)2.70377480
142dicarboxylic acid biosynthetic process (GO:0043650)2.68309039
143lung epithelium development (GO:0060428)2.67356899
144regulation of synapse maturation (GO:0090128)2.66964231
145tricarboxylic acid metabolic process (GO:0072350)2.66802364
146regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.65086148
147basement membrane organization (GO:0071711)2.65062667
148fructose metabolic process (GO:0006000)2.63446739
149glutamine family amino acid biosynthetic process (GO:0009084)2.61926348
150fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.60808559
151regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57748029
152myofibril assembly (GO:0030239)2.57677016
153regulation of cholesterol homeostasis (GO:2000188)2.56579637
154nitrogen cycle metabolic process (GO:0071941)2.55226401
155positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47493591
156semaphorin-plexin signaling pathway (GO:0071526)2.44553644
157regulation of translational fidelity (GO:0006450)2.43401835
158planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42736926
159tricarboxylic acid cycle (GO:0006099)2.42726440
160cell-cell junction maintenance (GO:0045217)2.41991899
161glycolytic process (GO:0006096)2.41014139
162regulation of glucose import in response to insulin stimulus (GO:2001273)2.38056095
163cerebellar Purkinje cell layer development (GO:0021680)2.36010823
164negative regulation of fatty acid biosynthetic process (GO:0045717)2.34267923
165cerebellar granule cell differentiation (GO:0021707)2.33948432
166glycogen catabolic process (GO:0005980)2.32774109
167phosphate ion transmembrane transport (GO:0035435)2.32567329
168GDP-mannose metabolic process (GO:0019673)2.32301636
169cellular modified amino acid catabolic process (GO:0042219)2.32029979
170apoptotic process involved in morphogenesis (GO:0060561)2.30275417
171response to parathyroid hormone (GO:0071107)2.29579473
172actomyosin structure organization (GO:0031032)2.29035978
173glutamate metabolic process (GO:0006536)2.26866608
174insulin-like growth factor receptor signaling pathway (GO:0048009)2.26862706
175regulation of fatty acid beta-oxidation (GO:0031998)2.25902828
176mannose metabolic process (GO:0006013)2.25262224
177skeletal muscle fiber development (GO:0048741)2.23423693
178maternal placenta development (GO:0001893)2.22909144
179respiratory system process (GO:0003016)2.22724878
180glucose 6-phosphate metabolic process (GO:0051156)2.21889799
181very-low-density lipoprotein particle assembly (GO:0034379)2.20679679
182atrioventricular valve morphogenesis (GO:0003181)2.17976175
183positive regulation of dendritic spine morphogenesis (GO:0061003)2.17550155
184negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.17417276
185regulation of skeletal muscle contraction (GO:0014819)2.15911096
186negative regulation of fibrinolysis (GO:0051918)2.15036090
187alpha-linolenic acid metabolic process (GO:0036109)2.14608566
188endothelial cell chemotaxis (GO:0035767)2.14185503
189carnitine shuttle (GO:0006853)2.13926936

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.93446504
2GBX2_23144817_ChIP-Seq_PC3_Human3.86035053
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.25605962
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.23483376
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08207190
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03935015
7ZNF263_19887448_ChIP-Seq_K562_Human2.96614750
8LXR_22292898_ChIP-Seq_THP-1_Human2.95194269
9REST_21632747_ChIP-Seq_MESCs_Mouse2.90492235
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.84775492
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81721993
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81721993
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.77716032
14TAF15_26573619_Chip-Seq_HEK293_Human2.72269384
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.69815303
16TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67243976
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58584294
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.58251670
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56583876
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51544023
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.49979503
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44595452
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43313217
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.41078852
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.39372161
26RACK7_27058665_Chip-Seq_MCF-7_Human2.38814818
27ESR2_21235772_ChIP-Seq_MCF-7_Human2.35315938
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33157342
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18398000
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.17815909
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.15168366
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.15018728
33DROSHA_22980978_ChIP-Seq_HELA_Human2.11727766
34EZH2_27294783_Chip-Seq_ESCs_Mouse2.08243360
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.01929328
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.95567047
37TET1_21451524_ChIP-Seq_MESCs_Mouse1.93998051
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91935526
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.90737254
40P68_20966046_ChIP-Seq_HELA_Human1.89248377
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85434622
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84813876
43SMC4_20622854_ChIP-Seq_HELA_Human1.83604114
44SMAD4_21799915_ChIP-Seq_A2780_Human1.81757795
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.80796849
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80787068
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.80613384
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76842165
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.75986582
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75725626
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74812406
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74419334
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72477584
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69824197
55CTCF_27219007_Chip-Seq_Bcells_Human1.68859928
56CREB1_26743006_Chip-Seq_LNCaP_Human1.67704871
57ERG_21242973_ChIP-ChIP_JURKAT_Human1.67172827
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.65216439
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.64956096
60P300_19829295_ChIP-Seq_ESCs_Human1.62078427
61KDM2B_26808549_Chip-Seq_DND41_Human1.61055943
62TP63_17297297_ChIP-ChIP_HaCaT_Human1.60789934
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.59150284
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57561442
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57435504
66VDR_21846776_ChIP-Seq_THP-1_Human1.57152620
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56322387
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.55344564
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54105922
70RXR_22158963_ChIP-Seq_LIVER_Mouse1.52853436
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52611013
72CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.51901512
73SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.50539925
74SA1_27219007_Chip-Seq_ERYTHROID_Human1.49583008
75* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48627641
76AR_21572438_ChIP-Seq_LNCaP_Human1.48132954
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46543463
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46155046
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44869407
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44018270
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42968610
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.42723213
83NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41327024
84TCF7_22412390_ChIP-Seq_EML_Mouse1.41080811
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39917094
86* SRY_22984422_ChIP-ChIP_TESTIS_Rat1.39747387
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39004508
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36767827
89AR_25329375_ChIP-Seq_VCAP_Human1.35509620
90HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.35484387
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35457579
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.34461835
93TRIM28_21343339_ChIP-Seq_HEK293_Human1.33064125
94ZNF274_21170338_ChIP-Seq_K562_Hela1.32960889
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.31370610
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30833478
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30292999
98RNF2_27304074_Chip-Seq_NSC_Mouse1.29228719
99MYC_22102868_ChIP-Seq_BL_Human1.27132871
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27080764
101CLOCK_20551151_ChIP-Seq_293T_Human1.26814087
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25806810
103STAT3_23295773_ChIP-Seq_U87_Human1.25709434
104RUNX1_27514584_Chip-Seq_MCF-7_Human1.25604783
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25289894
106RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22847347
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.22546122
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.22319256
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21627205
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19686126
111ELF1_20517297_ChIP-Seq_JURKAT_Human1.19447338
112ESR1_21235772_ChIP-Seq_MCF-7_Human1.19198335
113RING1B_27294783_Chip-Seq_ESCs_Mouse1.18926675
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.18722673
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.18293570
116AHR_22903824_ChIP-Seq_MCF-7_Human1.18100646
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.18086966
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17930236
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17370586
120TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17254466
121P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16834196
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.16292059
123NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14747977
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13763917
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12458191
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11700151
127AR_19668381_ChIP-Seq_PC3_Human1.10815570
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.09992426
129BCOR_27268052_Chip-Seq_Bcells_Human1.09881989
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.09392531
131SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09067475
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.08986111
133HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08850918
134PIAS1_25552417_ChIP-Seq_VCAP_Human1.08836233
135SMAD_19615063_ChIP-ChIP_OVARY_Human1.08265779
136TCF4_23295773_ChIP-Seq_U87_Human1.08244412
137FOXP1_21924763_ChIP-Seq_HESCs_Human1.07096022
138ATF3_27146783_Chip-Seq_COLON_Human1.07073062
139KDM2B_26808549_Chip-Seq_JURKAT_Human1.06922451
140KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04883984
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04717043
142SA1_27219007_Chip-Seq_Bcells_Human1.04481715
143KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.04242053
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03924870
145SMAD3_21741376_ChIP-Seq_ESCs_Human1.01753187
146CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01452469
147KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01345890
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01088453
149BCAT_22108803_ChIP-Seq_LS180_Human1.00563209
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00327325
151CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00278946
152PHF8_20622854_ChIP-Seq_HELA_Human1.00250150
153YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00190893
154THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00019199
155PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99771800
156UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99479306
157TP53_22127205_ChIP-Seq_IMR90_Human0.99448622
158TBX20_22328084_ChIP-Seq_HEART_Mouse0.99188312
159TBX20_22080862_ChIP-Seq_HEART_Mouse0.99188312
160NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.98741058
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.98720780
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98542258
163ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98265307
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98005086
165JUN_21703547_ChIP-Seq_K562_Human0.97475603
166RUNX2_22187159_ChIP-Seq_PCA_Human0.96786061
167* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95393780
168CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95147263
169CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95031262
170AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94755388
171IGF1R_20145208_ChIP-Seq_DFB_Human0.92044961
172RING1B_27294783_Chip-Seq_NPCs_Mouse0.91948267
173POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91860635
174MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90861181
175TET1_21490601_ChIP-Seq_MESCs_Mouse0.90658666
176VDR_22108803_ChIP-Seq_LS180_Human0.89377596
177MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88886514
178EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87542665
179RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86897512
180POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86553187
181TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86553187
182CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86457223
183SOX9_26525672_Chip-Seq_HEART_Mouse0.86326213
184* KDM2B_26808549_Chip-Seq_K562_Human0.85969513
185NANOG_18555785_Chip-Seq_ESCs_Mouse0.85807002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.65247228
2MP0003880_abnormal_central_pattern4.88764354
3MP0004270_analgesia4.15836096
4MP0002735_abnormal_chemical_nociception3.94328628
5MP0001968_abnormal_touch/_nociception3.87974576
6MP0003635_abnormal_synaptic_transmissio3.76564839
7MP0005451_abnormal_body_composition3.60583731
8MP0002736_abnormal_nociception_after3.37885891
9MP0009046_muscle_twitch3.37186243
10MP0002734_abnormal_mechanical_nocicepti3.20398457
11MP0002064_seizures3.11384187
12MP0003705_abnormal_hypodermis_morpholog3.05632371
13MP0009745_abnormal_behavioral_response3.00289616
14MP0002063_abnormal_learning/memory/cond2.88675971
15MP0002272_abnormal_nervous_system2.76322653
16MP0002733_abnormal_thermal_nociception2.67852634
17MP0004858_abnormal_nervous_system2.61053789
18MP0002572_abnormal_emotion/affect_behav2.53358396
19MP0001970_abnormal_pain_threshold2.53192859
20MP0001486_abnormal_startle_reflex2.36460388
21MP0006276_abnormal_autonomic_nervous2.35710245
22MP0002067_abnormal_sensory_capabilities2.25521831
23MP0004036_abnormal_muscle_relaxation2.23529701
24MP0001984_abnormal_olfaction2.20850594
25MP0002184_abnormal_innervation2.20357871
26MP0005360_urolithiasis2.16888109
27MP0000747_muscle_weakness2.16418418
28MP0001440_abnormal_grooming_behavior2.08809710
29MP0004087_abnormal_muscle_fiber2.05774271
30MP0003123_paternal_imprinting2.05251959
31MP0005423_abnormal_somatic_nervous2.03928082
32MP0001501_abnormal_sleep_pattern2.01273981
33MP0002249_abnormal_larynx_morphology2.01046374
34MP0010030_abnormal_orbit_morphology1.99656149
35MP0005330_cardiomyopathy1.97678227
36MP0004084_abnormal_cardiac_muscle1.94648472
37MP0005058_abnormal_lysosome_morphology1.93804317
38MP0008569_lethality_at_weaning1.91501797
39MP0000759_abnormal_skeletal_muscle1.91202966
40MP0005409_darkened_coat_color1.90638242
41MP0003329_amyloid_beta_deposits1.84839358
42MP0004811_abnormal_neuron_physiology1.84172245
43MP0001346_abnormal_lacrimal_gland1.83782027
44MP0002269_muscular_atrophy1.78825664
45MP0000750_abnormal_muscle_regeneration1.78496427
46MP0009840_abnormal_foam_cell1.77584050
47MP0002822_catalepsy1.76927455
48MP0000955_abnormal_spinal_cord1.75624301
49MP0005670_abnormal_white_adipose1.72510248
50MP0005386_behavior/neurological_phenoty1.69067155
51MP0004924_abnormal_behavior1.69067155
52MP0000003_abnormal_adipose_tissue1.68604221
53MP0003879_abnormal_hair_cell1.63866425
54MP0004185_abnormal_adipocyte_glucose1.62708608
55MP0000733_abnormal_muscle_development1.61400002
56MP0000778_abnormal_nervous_system1.59865499
57MP0002557_abnormal_social/conspecific_i1.54551097
58MP0002106_abnormal_muscle_physiology1.51524406
59MP0005666_abnormal_adipose_tissue1.51096113
60MP0003183_abnormal_peptide_metabolism1.50884297
61MP0004142_abnormal_muscle_tone1.49591878
62MP0002882_abnormal_neuron_morphology1.49435840
63MP0001905_abnormal_dopamine_level1.46643228
64MP0005083_abnormal_biliary_tract1.44854156
65MP0010630_abnormal_cardiac_muscle1.43925012
66MP0002066_abnormal_motor_capabilities/c1.39078136
67MP0002089_abnormal_postnatal_growth/wei1.38349173
68MP0006138_congestive_heart_failure1.37016851
69MP0005646_abnormal_pituitary_gland1.36860331
70MP0000566_synostosis1.35123058
71MP0004130_abnormal_muscle_cell1.34808506
72MP0005369_muscle_phenotype1.34433823
73MP0001986_abnormal_taste_sensitivity1.32725649
74MP0005375_adipose_tissue_phenotype1.32491635
75MP0001529_abnormal_vocalization1.26409861
76MP0000678_abnormal_parathyroid_gland1.26290505
77MP0000013_abnormal_adipose_tissue1.25465584
78MP0003137_abnormal_impulse_conducting1.24746120
79MP0009780_abnormal_chondrocyte_physiolo1.24645525
80MP0003633_abnormal_nervous_system1.21730145
81MP0003787_abnormal_imprinting1.21703957
82MP0005076_abnormal_cell_differentiation1.21098113
83MP0003122_maternal_imprinting1.17019543
84MP0002229_neurodegeneration1.16168385
85MP0002972_abnormal_cardiac_muscle1.16131724
86MP0001661_extended_life_span1.14198794
87MP0002909_abnormal_adrenal_gland1.14083854
88MP0001849_ear_inflammation1.13971612
89MP0002108_abnormal_muscle_morphology1.10486986
90MP0000751_myopathy1.10020378
91MP0005620_abnormal_muscle_contractility1.09452223
92MP0003631_nervous_system_phenotype1.07548048
93MP0001502_abnormal_circadian_rhythm1.05618641
94MP0002751_abnormal_autonomic_nervous1.02451281
95MP0005365_abnormal_bile_salt1.01106285
96MP0002152_abnormal_brain_morphology0.98515769
97MP0001963_abnormal_hearing_physiology0.98353863
98MP0008260_abnormal_autophagy0.97127698
99MP0002752_abnormal_somatic_nervous0.96539760
100MP0008872_abnormal_physiological_respon0.95721364
101MP0004742_abnormal_vestibular_system0.95191104
102MP0001188_hyperpigmentation0.94607682
103MP0004145_abnormal_muscle_electrophysio0.92952558
104MP0004885_abnormal_endolymph0.92819478
105MP0008874_decreased_physiological_sensi0.92510762
106MP0004510_myositis0.92356634
107MP0000537_abnormal_urethra_morphology0.91545077
108MP0003634_abnormal_glial_cell0.89539795
109MP0003942_abnormal_urinary_system0.89267060
110MP0010234_abnormal_vibrissa_follicle0.88551079
111MP0001485_abnormal_pinna_reflex0.88272231
112MP0008438_abnormal_cutaneous_collagen0.87861523
113MP0009384_cardiac_valve_regurgitation0.85286945
114MP0000604_amyloidosis0.84742214
115MP0004147_increased_porphyrin_level0.84279549
116MP0005645_abnormal_hypothalamus_physiol0.82444096
117MP0010329_abnormal_lipoprotein_level0.82341926
118MP0002653_abnormal_ependyma_morphology0.81842570
119MP0005410_abnormal_fertilization0.81497859
120MP0004085_abnormal_heartbeat0.80190562
121MP0005499_abnormal_olfactory_system0.78994531
122MP0005394_taste/olfaction_phenotype0.78994531
123MP0003566_abnormal_cell_adhesion0.77972645
124MP0002069_abnormal_eating/drinking_beha0.77551536
125MP0002837_dystrophic_cardiac_calcinosis0.76818569
126MP0000534_abnormal_ureter_morphology0.76774225
127MP0005171_absent_coat_pigmentation0.75034950
128MP0002139_abnormal_hepatobiliary_system0.74492256
129MP0009672_abnormal_birth_weight0.73603117
130MP0001664_abnormal_digestion0.73387386
131MP0003632_abnormal_nervous_system0.73122364
132MP0002971_abnormal_brown_adipose0.71745240
133MP0005332_abnormal_amino_acid0.71551075
134MP0005535_abnormal_body_temperature0.71296678
135MP0000681_abnormal_thyroid_gland0.70763883
136MP0006036_abnormal_mitochondrial_physio0.69910380
137MP0003172_abnormal_lysosome_physiology0.69625450
138MP0002876_abnormal_thyroid_physiology0.68316898
139MP0000920_abnormal_myelination0.68032246
140MP0008775_abnormal_heart_ventricle0.65228148
141MP0008877_abnormal_DNA_methylation0.64964924
142MP0004272_abnormal_basement_membrane0.64722506
143MP0002118_abnormal_lipid_homeostasis0.64585332
144MP0005623_abnormal_meninges_morphology0.64003911
145MP0001544_abnormal_cardiovascular_syste0.62847349
146MP0005385_cardiovascular_system_phenoty0.62847349
147MP0005551_abnormal_eye_electrophysiolog0.62439969
148MP0001299_abnormal_eye_distance/0.61363465
149MP0004215_abnormal_myocardial_fiber0.61010559
150MP0004264_abnormal_extraembryonic_tissu0.60637797
151MP0001666_abnormal_nutrient_absorption0.59901932
152MP0002163_abnormal_gland_morphology0.59712229
153MP0002160_abnormal_reproductive_system0.59452409
154MP0001177_atelectasis0.59198393
155MP0000749_muscle_degeneration0.58995738
156MP0001348_abnormal_lacrimal_gland0.58646834
157MP0004484_altered_response_of0.58472996
158MP0000639_abnormal_adrenal_gland0.58261673
159MP0001943_abnormal_respiration0.56939648
160MP0003385_abnormal_body_wall0.56732259
161MP0003115_abnormal_respiratory_system0.56396005
162MP0010769_abnormal_survival0.52919456
163MP0004233_abnormal_muscle_weight0.52890969
164MP0010770_preweaning_lethality0.52211606
165MP0002082_postnatal_lethality0.52211606
166MP0003646_muscle_fatigue0.51751352
167MP0003956_abnormal_body_size0.50880804
168MP0010768_mortality/aging0.49939374

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.46533928
2Focal motor seizures (HP:0011153)7.45746424
3Atonic seizures (HP:0010819)6.05913886
4Focal seizures (HP:0007359)5.78540309
5Febrile seizures (HP:0002373)5.51948058
6Epileptic encephalopathy (HP:0200134)4.85758644
7Progressive cerebellar ataxia (HP:0002073)4.73471219
8Action tremor (HP:0002345)4.61892348
9Absence seizures (HP:0002121)4.46283269
10Visual hallucinations (HP:0002367)4.32490248
11Exercise-induced myalgia (HP:0003738)4.16182526
12Dialeptic seizures (HP:0011146)4.11633873
13Pheochromocytoma (HP:0002666)4.03576305
14Generalized tonic-clonic seizures (HP:0002069)3.90340410
15Ulnar claw (HP:0001178)3.84253486
16Myopathic facies (HP:0002058)3.82297537
17Muscle fiber inclusion bodies (HP:0100299)3.80732178
18Neuroendocrine neoplasm (HP:0100634)3.79230443
19Type 1 muscle fiber predominance (HP:0003803)3.74372574
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.71479116
21Nemaline bodies (HP:0003798)3.63985734
22Deep venous thrombosis (HP:0002625)3.57031915
23Distal lower limb muscle weakness (HP:0009053)3.46635848
24Gaze-evoked nystagmus (HP:0000640)3.42482553
25Insidious onset (HP:0003587)3.42480800
26Termporal pattern (HP:0011008)3.42480800
27Ankle clonus (HP:0011448)3.21606028
28Truncal ataxia (HP:0002078)3.20552999
29Centrally nucleated skeletal muscle fibers (HP:0003687)3.20340463
30Supranuclear gaze palsy (HP:0000605)3.19321733
31Increased connective tissue (HP:0009025)3.01456827
32Hyporeflexia of lower limbs (HP:0002600)2.97712921
33Impaired vibration sensation in the lower limbs (HP:0002166)2.96666658
34Limb dystonia (HP:0002451)2.95952685
35Distal lower limb amyotrophy (HP:0008944)2.95757313
36Amblyopia (HP:0000646)2.91443998
37Sudden death (HP:0001699)2.90530786
38Hyperventilation (HP:0002883)2.85812274
39Abnormality of the lower motor neuron (HP:0002366)2.85224250
40Urinary bladder sphincter dysfunction (HP:0002839)2.80662549
41Exercise-induced muscle cramps (HP:0003710)2.80411407
42Mildly elevated creatine phosphokinase (HP:0008180)2.77309188
43Bundle branch block (HP:0011710)2.74724530
44Abnormality of the Achilles tendon (HP:0005109)2.72971811
45Asymmetric septal hypertrophy (HP:0001670)2.69713580
46Achilles tendon contracture (HP:0001771)2.65339986
47Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.61362512
48Scanning speech (HP:0002168)2.58968203
49Neoplasm of the peripheral nervous system (HP:0100007)2.58580513
50Myoglobinuria (HP:0002913)2.58274999
51Hyperacusis (HP:0010780)2.58148615
52Round ear (HP:0100830)2.58065724
53Depression (HP:0000716)2.57958819
54Urinary urgency (HP:0000012)2.56354066
55Abnormal eating behavior (HP:0100738)2.55093157
56EMG: myopathic abnormalities (HP:0003458)2.53945862
57Failure to thrive in infancy (HP:0001531)2.53687122
58Broad-based gait (HP:0002136)2.52502659
59Rhabdomyolysis (HP:0003201)2.50009549
60Impaired smooth pursuit (HP:0007772)2.46708956
61Dysmetria (HP:0001310)2.45545928
62Cerebral aneurysm (HP:0004944)2.45335350
63Poor eye contact (HP:0000817)2.43693526
64Reticulocytosis (HP:0001923)2.41796755
65Fetal akinesia sequence (HP:0001989)2.40452858
66Anxiety (HP:0000739)2.40082040
67Spastic gait (HP:0002064)2.39591930
68Increased variability in muscle fiber diameter (HP:0003557)2.39135703
69Dysdiadochokinesis (HP:0002075)2.38232310
70Difficulty climbing stairs (HP:0003551)2.38219016
71Abnormal atrioventricular conduction (HP:0005150)2.37659191
72Abnormality of skeletal muscle fiber size (HP:0012084)2.37375946
73Ventricular tachycardia (HP:0004756)2.37201217
74Obstructive sleep apnea (HP:0002870)2.35360570
75Ventricular fibrillation (HP:0001663)2.33951876
76Abnormal hair whorl (HP:0010721)2.31545146
77Abnormality of pain sensation (HP:0010832)2.31523728
78Impaired pain sensation (HP:0007328)2.31523728
79Ulnar deviation of the wrist (HP:0003049)2.29833322
80Lower limb amyotrophy (HP:0007210)2.28519796
81Abnormality of the calf musculature (HP:0001430)2.27815209
82Progressive inability to walk (HP:0002505)2.26944628
83Stridor (HP:0010307)2.26685134
84Impaired social interactions (HP:0000735)2.26179891
85Abnormal social behavior (HP:0012433)2.26179891
86Postural instability (HP:0002172)2.25770915
87EMG: neuropathic changes (HP:0003445)2.25098503
88Ulnar bowing (HP:0003031)2.24297796
89Bulbar palsy (HP:0001283)2.23881570
90Specific learning disability (HP:0001328)2.23482547
91Abnormality of ocular smooth pursuit (HP:0000617)2.20815491
92Distal upper limb amyotrophy (HP:0007149)2.20616457
93Upper limb amyotrophy (HP:0009129)2.20616457
94Heart block (HP:0012722)2.20450541
95Postural tremor (HP:0002174)2.20439185
96Dysmetric saccades (HP:0000641)2.20128647
97Muscle hypertrophy of the lower extremities (HP:0008968)2.19760284
98Epileptiform EEG discharges (HP:0011182)2.17252329
99Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17229992
100Hypoplasia of the brainstem (HP:0002365)2.17229992
101Inability to walk (HP:0002540)2.16663448
102Bradykinesia (HP:0002067)2.16457438
103Ragged-red muscle fibers (HP:0003200)2.16389185
104Status epilepticus (HP:0002133)2.15496156
105Myotonia (HP:0002486)2.14396845
106Protrusio acetabuli (HP:0003179)2.12730818
107Broad face (HP:0000283)2.12154553
108Impaired vibratory sensation (HP:0002495)2.11044914
109Akinesia (HP:0002304)2.10645866
110Progressive muscle weakness (HP:0003323)2.10076050
111Absent speech (HP:0001344)2.09249974
112Torticollis (HP:0000473)2.08481696
113Delusions (HP:0000746)2.07308965
114Hemorrhage of the eye (HP:0011885)2.06764159
115Gait ataxia (HP:0002066)2.06510606
116Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05140848
117Focal dystonia (HP:0004373)2.05058964
118Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04892401
119Calf muscle hypertrophy (HP:0008981)2.04810009
120Cholelithiasis (HP:0001081)2.03805879
121EEG with generalized epileptiform discharges (HP:0011198)2.02776847
122Hypoventilation (HP:0002791)2.01520991
123Abnormality of the vocal cords (HP:0008777)1.98211167
124Abnormality of the corticospinal tract (HP:0002492)1.97204588
125Neck muscle weakness (HP:0000467)1.96734640
126Genetic anticipation (HP:0003743)1.96617965
127Scapular winging (HP:0003691)1.95573442
128Hypsarrhythmia (HP:0002521)1.94604317
129Lymphangioma (HP:0100764)1.94312861
130Spinal rigidity (HP:0003306)1.93880701
131Hammertoe (HP:0001765)1.93607959
132Muscle fiber splitting (HP:0003555)1.92524512
133Abnormal gallbladder physiology (HP:0012438)1.91937486
134Cholecystitis (HP:0001082)1.91937486
135Thin ribs (HP:0000883)1.91219492
136Hypothermia (HP:0002045)1.90740195
137Gait imbalance (HP:0002141)1.90494846
138Lower limb muscle weakness (HP:0007340)1.90410838
139Testicular atrophy (HP:0000029)1.89827780
140Muscle stiffness (HP:0003552)1.88728374
141Annular pancreas (HP:0001734)1.88129542
142Flat acetabular roof (HP:0003180)1.87962503
143Sensory axonal neuropathy (HP:0003390)1.87894729
144Vertebral compression fractures (HP:0002953)1.87564317
145Dilated cardiomyopathy (HP:0001644)1.87052472
146Hypercortisolism (HP:0001578)1.87050280
147Resting tremor (HP:0002322)1.86991895
148Calcaneovalgus deformity (HP:0001848)1.86636552
149Abnormality of the foot musculature (HP:0001436)1.86431577
150Craniofacial dystonia (HP:0012179)1.86189987
151Insomnia (HP:0100785)1.84736312
152Incomplete penetrance (HP:0003829)1.84510287
153Hemiparesis (HP:0001269)1.84014677
154Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.83843652
155Rigidity (HP:0002063)1.83780200
156Distal arthrogryposis (HP:0005684)1.83705270
157Subaortic stenosis (HP:0001682)1.83334252
158Abnormality of the left ventricular outflow tract (HP:0011103)1.83334252
159Foot dorsiflexor weakness (HP:0009027)1.82885275
160Atrioventricular block (HP:0001678)1.82460184
161Steppage gait (HP:0003376)1.82151001
162Poor suck (HP:0002033)1.82075756
163Abnormality of the aortic arch (HP:0012303)1.80629818
164Abnormality of glycolysis (HP:0004366)1.80487506
165Back pain (HP:0003418)1.78888582
166Hypercholesterolemia (HP:0003124)1.78784812
167Thin bony cortex (HP:0002753)1.78255656
168Mutism (HP:0002300)1.76780240
169Sparse lateral eyebrow (HP:0005338)1.76675891
170Hemiplegia (HP:0002301)1.75121753
171Bronchomalacia (HP:0002780)1.75056323
172Bradycardia (HP:0001662)1.74951261
173Blue irides (HP:0000635)1.74456588
174Excessive salivation (HP:0003781)1.72993400
175Drooling (HP:0002307)1.72993400
176Genital tract atresia (HP:0001827)1.72853356
177Generalized amyotrophy (HP:0003700)1.71957783
178Retinal dysplasia (HP:0007973)1.71765428
179Stereotypic behavior (HP:0000733)1.71638916
180Abnormality of the tricuspid valve (HP:0001702)1.70932225
181Biconcave vertebral bodies (HP:0004586)1.68494694
182Hypoalphalipoproteinemia (HP:0003233)1.67115225
183Asymmetry of the thorax (HP:0001555)1.66504234
184Easy fatigability (HP:0003388)1.66118471
185Abnormal gallbladder morphology (HP:0012437)1.65231082
186Abnormality of the calcaneus (HP:0008364)1.64795070
187Ventricular arrhythmia (HP:0004308)1.64783149
188Infantile muscular hypotonia (HP:0008947)1.64451484
189Cerebral inclusion bodies (HP:0100314)1.63465319
190Hyperthyroidism (HP:0000836)1.63070788
191Xanthomatosis (HP:0000991)1.62038934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.40322756
2NTRK34.47445149
3ICK3.77247142
4MAP3K93.45904784
5CASK3.33128681
6MAP3K43.23578536
7MAP3K123.21146421
8MINK13.03330148
9TTN2.96772487
10MAP2K72.93606543
11SIK12.86986792
12EPHA42.66278638
13CDK192.66040916
14DAPK22.55340697
15PKN22.52392576
16EEF2K2.34485028
17OBSCN2.21033659
18MAP2K42.19910530
19PAK62.17307656
20GRK52.03565121
21LMTK21.99936764
22EPHA21.89658041
23KSR21.88974841
24PLK21.85516380
25DAPK11.84986280
26SMG11.79462859
27ARAF1.78623803
28FGFR41.75727298
29RIPK11.74004290
30TESK11.70236448
31RIPK41.69532842
32NTRK11.68909856
33TESK21.62833458
34MARK11.62142781
35ERN11.60455872
36LATS21.49564873
37MAPK131.46643339
38CAMKK11.42022041
39MUSK1.40736927
40CDK51.38790151
41OXSR11.36670925
42CAMKK21.34615185
43IRAK31.33193883
44NTRK21.31283051
45MST1R1.28753397
46PRKD31.23198099
47PRPF4B1.20900248
48PRKCG1.20869907
49MARK21.19743312
50SIK31.18598960
51MTOR1.16558508
52MAPKAPK51.16380151
53UHMK11.15529599
54SGK2231.11370484
55SGK4941.11370484
56RET1.11325811
57AKT31.10892476
58CDK181.09778076
59KSR11.08851578
60PDGFRA1.07967185
61MAP3K21.06421370
62CDK141.06398013
63SGK21.05847787
64PTK2B1.04019197
65MAPK121.03247693
66NME21.02000894
67CDK151.01946940
68STK381.01145473
69PHKG11.00125219
70PHKG21.00125219
71PNCK0.99517198
72CDK120.98457442
73DMPK0.98033826
74PTK20.94050956
75CCNB10.92475248
76LIMK10.89962762
77CDK11A0.89162896
78PINK10.87199785
79CAMK2A0.86957036
80MAPKAPK30.85952595
81CAMK1D0.84721946
82MAP2K30.83244993
83WNK10.83021362
84CAMK2B0.77811141
85MET0.77765677
86SGK30.76948944
87PIM20.74621150
88MAPK110.74249656
89BRAF0.73962427
90ILK0.72666483
91PTK60.71831401
92MAP3K70.71372428
93CDK80.70880216
94NEK10.69394664
95TAOK10.69287981
96PDK40.69219372
97PDK30.69219372
98FES0.68970360
99PRKD20.68560714
100CAMK10.68435898
101STK390.68038906
102PRKCH0.67614480
103CAMK2G0.66748148
104AKT20.66149673
105CAMK2D0.66018265
106DYRK1B0.65321280
107PDPK10.64936047
108PDK10.64674455
109TNIK0.64393257
110CDK70.62392795
111RPS6KB20.62373840
112MAP2K60.62202921
113BMPR20.62053260
114BMX0.61574721
115TAOK20.61503914
116CDC42BPA0.60778228
117MAP2K10.60038414
118MAP2K20.59765276
119MAP3K60.58812506
120PRKAA10.57524698
121BCR0.56898705
122TSSK60.56672259
123STK110.56023762
124PAK40.55006369
125TNK20.54280577
126FER0.51383855
127PAK30.51244319
128CAMK1G0.51062700
129MAP3K10.51036344
130TYRO30.49819934
131RPS6KA20.49486191
132PRKD10.49267799
133WNK40.49255154
134LRRK20.48147437
135NEK60.47833290
136RPS6KL10.47800089
137RPS6KC10.47800089
138MAP3K130.47654863
139ADRBK10.45913951
140SIK20.43330341
141BRSK10.42854693
142DDR20.42695300
143RAF10.42356522
144DAPK30.42315547
145CSNK1G20.41549894
146PRKAA20.38750436
147PRKCE0.38429384
148SGK10.37842324
149CAMK40.36770082
150MAP3K110.36405550
151ROCK20.35875701
152ALK0.34351027
153NME10.33997824
154RPS6KA30.32778481
155MAPK100.31471010

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.36926459
2Nicotine addiction_Homo sapiens_hsa050333.40846444
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.24861337
4Olfactory transduction_Homo sapiens_hsa047403.23409985
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.60272130
6Collecting duct acid secretion_Homo sapiens_hsa049662.53108725
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.46511811
8Arginine biosynthesis_Homo sapiens_hsa002202.44145510
9Circadian entrainment_Homo sapiens_hsa047132.41170027
10Long-term potentiation_Homo sapiens_hsa047202.39756985
11Biosynthesis of amino acids_Homo sapiens_hsa012302.36008237
12Sulfur relay system_Homo sapiens_hsa041222.33621486
13GABAergic synapse_Homo sapiens_hsa047272.27356357
14Taste transduction_Homo sapiens_hsa047422.26304739
15Glutamatergic synapse_Homo sapiens_hsa047242.25818036
16Amphetamine addiction_Homo sapiens_hsa050312.23001993
17Morphine addiction_Homo sapiens_hsa050322.18742047
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.15508200
19Salivary secretion_Homo sapiens_hsa049702.10543643
20Dopaminergic synapse_Homo sapiens_hsa047282.09316175
21Phenylalanine metabolism_Homo sapiens_hsa003602.08520710
22Insulin secretion_Homo sapiens_hsa049112.05928197
23Carbon metabolism_Homo sapiens_hsa012001.78718367
24Cyanoamino acid metabolism_Homo sapiens_hsa004601.78455654
25Arginine and proline metabolism_Homo sapiens_hsa003301.77687871
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71731985
27Gastric acid secretion_Homo sapiens_hsa049711.71218540
28Cholinergic synapse_Homo sapiens_hsa047251.69986787
29Vitamin B6 metabolism_Homo sapiens_hsa007501.67202801
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64283194
31Other glycan degradation_Homo sapiens_hsa005111.59508316
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55036718
33Vibrio cholerae infection_Homo sapiens_hsa051101.54898262
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.52218219
35Serotonergic synapse_Homo sapiens_hsa047261.50108976
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49988398
37Calcium signaling pathway_Homo sapiens_hsa040201.46696215
38Pentose phosphate pathway_Homo sapiens_hsa000301.43457573
39Long-term depression_Homo sapiens_hsa047301.42607778
40Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.41009338
41Oxytocin signaling pathway_Homo sapiens_hsa049211.39570619
42Cardiac muscle contraction_Homo sapiens_hsa042601.38899657
43Renin secretion_Homo sapiens_hsa049241.38239094
44Oxidative phosphorylation_Homo sapiens_hsa001901.36769626
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.34360370
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.32222782
47GnRH signaling pathway_Homo sapiens_hsa049121.28666679
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.26078816
49Galactose metabolism_Homo sapiens_hsa000521.24861355
50Gap junction_Homo sapiens_hsa045401.17619846
51Cocaine addiction_Homo sapiens_hsa050301.15942514
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.15405792
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14324419
54AMPK signaling pathway_Homo sapiens_hsa041521.14301700
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13509337
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13019701
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.12262919
58cAMP signaling pathway_Homo sapiens_hsa040241.11131227
59Parkinsons disease_Homo sapiens_hsa050121.08210193
60Tyrosine metabolism_Homo sapiens_hsa003501.07043739
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07009354
62Oocyte meiosis_Homo sapiens_hsa041141.06480070
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.03355652
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02383193
65ErbB signaling pathway_Homo sapiens_hsa040121.02100893
66Fatty acid metabolism_Homo sapiens_hsa012120.99032913
67Glioma_Homo sapiens_hsa052140.98811277
68PPAR signaling pathway_Homo sapiens_hsa033200.97470691
69Type II diabetes mellitus_Homo sapiens_hsa049300.97264125
70Alzheimers disease_Homo sapiens_hsa050100.97262213
71Notch signaling pathway_Homo sapiens_hsa043300.93745672
72Estrogen signaling pathway_Homo sapiens_hsa049150.92470444
73Dorso-ventral axis formation_Homo sapiens_hsa043200.91106020
74Lysine degradation_Homo sapiens_hsa003100.89341226
75Melanogenesis_Homo sapiens_hsa049160.87498178
76Fatty acid biosynthesis_Homo sapiens_hsa000610.86330644
77Axon guidance_Homo sapiens_hsa043600.84405797
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83369123
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83130254
80Phototransduction_Homo sapiens_hsa047440.78866556
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78252458
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77422587
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76239553
84Pancreatic secretion_Homo sapiens_hsa049720.75900875
85Fatty acid degradation_Homo sapiens_hsa000710.75024211
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.73158915
87Insulin resistance_Homo sapiens_hsa049310.72005399
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.71030023
89Huntingtons disease_Homo sapiens_hsa050160.68235407
90Complement and coagulation cascades_Homo sapiens_hsa046100.67449545
91Histidine metabolism_Homo sapiens_hsa003400.67373756
92Thyroid hormone synthesis_Homo sapiens_hsa049180.67323868
93MAPK signaling pathway_Homo sapiens_hsa040100.65447894
94Non-small cell lung cancer_Homo sapiens_hsa052230.65274995
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64223571
96Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62631496
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62473686
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59927507
99Inositol phosphate metabolism_Homo sapiens_hsa005620.58556311
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.58290493
101Glucagon signaling pathway_Homo sapiens_hsa049220.55794003
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.55444802
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55353490
104Regulation of autophagy_Homo sapiens_hsa041400.54802874
105Fatty acid elongation_Homo sapiens_hsa000620.54273556
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53934371
107Insulin signaling pathway_Homo sapiens_hsa049100.53835020
108Bladder cancer_Homo sapiens_hsa052190.53550271
109ABC transporters_Homo sapiens_hsa020100.53060338
110VEGF signaling pathway_Homo sapiens_hsa043700.52541674
111Folate biosynthesis_Homo sapiens_hsa007900.52082944
112Tight junction_Homo sapiens_hsa045300.52052303
113Endocytosis_Homo sapiens_hsa041440.51920862
114Ras signaling pathway_Homo sapiens_hsa040140.51349388
115Rheumatoid arthritis_Homo sapiens_hsa053230.50320217
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49304419
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.48792914
118Choline metabolism in cancer_Homo sapiens_hsa052310.47723705
119Phagosome_Homo sapiens_hsa041450.47066928
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47038325
121Focal adhesion_Homo sapiens_hsa045100.46719433
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46068294
123Rap1 signaling pathway_Homo sapiens_hsa040150.45758316
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.44939998
125Ovarian steroidogenesis_Homo sapiens_hsa049130.44739560
126Chronic myeloid leukemia_Homo sapiens_hsa052200.43578672
127Bile secretion_Homo sapiens_hsa049760.41796712
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.41357989
129Dilated cardiomyopathy_Homo sapiens_hsa054140.41255396
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39493019
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39467694
132Alcoholism_Homo sapiens_hsa050340.38038873
133Endometrial cancer_Homo sapiens_hsa052130.37204669
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36570671
135Melanoma_Homo sapiens_hsa052180.35434359
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.34800001
137mTOR signaling pathway_Homo sapiens_hsa041500.34448069
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33628603
139Pyruvate metabolism_Homo sapiens_hsa006200.31145788
140Fructose and mannose metabolism_Homo sapiens_hsa000510.29280126
141Mineral absorption_Homo sapiens_hsa049780.28558831
142Prolactin signaling pathway_Homo sapiens_hsa049170.27926062
143Wnt signaling pathway_Homo sapiens_hsa043100.26000357
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24503526
145Salmonella infection_Homo sapiens_hsa051320.24270132
146Prion diseases_Homo sapiens_hsa050200.23845386
147Thyroid cancer_Homo sapiens_hsa052160.23578201

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