NECTIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)7.44874266
2fatty acid elongation (GO:0030497)7.18964378
3axon ensheathment in central nervous system (GO:0032291)7.08902456
4central nervous system myelination (GO:0022010)7.08902456
5multicellular organismal water homeostasis (GO:0050891)5.42302986
6keratinocyte differentiation (GO:0030216)5.16432488
7cell-substrate junction assembly (GO:0007044)5.03448299
8intermediate filament organization (GO:0045109)5.03364665
9planar cell polarity pathway involved in neural tube closure (GO:0090179)4.93000607
10epithelial cell differentiation involved in prostate gland development (GO:0060742)4.87725326
11desmosome organization (GO:0002934)4.82102021
12L-phenylalanine catabolic process (GO:0006559)4.81779104
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.81779104
14negative regulation of keratinocyte proliferation (GO:0010839)4.75856991
15long-chain fatty acid biosynthetic process (GO:0042759)4.71399433
16establishment of planar polarity (GO:0001736)4.58809243
17establishment of tissue polarity (GO:0007164)4.58809243
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.55999681
19cytoskeletal anchoring at plasma membrane (GO:0007016)4.53848760
20gap junction assembly (GO:0016264)4.53639040
21epidermis development (GO:0008544)4.49283079
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.35665165
23L-phenylalanine metabolic process (GO:0006558)4.35665165
24water homeostasis (GO:0030104)4.29881557
25polarized epithelial cell differentiation (GO:0030859)4.27413641
26ensheathment of neurons (GO:0007272)4.17430498
27axon ensheathment (GO:0008366)4.17430498
28epidermal cell differentiation (GO:0009913)4.13886129
29myelination (GO:0042552)4.11783089
30cholesterol biosynthetic process (GO:0006695)4.09810487
31long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.05725163
32epithelial cell-cell adhesion (GO:0090136)3.93675688
33very long-chain fatty acid metabolic process (GO:0000038)3.92136171
34sodium ion export (GO:0071436)3.89317547
35surfactant homeostasis (GO:0043129)3.86966537
36long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.83110080
37fatty-acyl-CoA biosynthetic process (GO:0046949)3.81294167
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.74045301
39regulation of hair follicle development (GO:0051797)3.69011625
40fatty-acyl-CoA metabolic process (GO:0035337)3.62675617
41semaphorin-plexin signaling pathway (GO:0071526)3.59556375
42sterol biosynthetic process (GO:0016126)3.56869470
43regulation of keratinocyte proliferation (GO:0010837)3.55318953
44cell communication involved in cardiac conduction (GO:0086065)3.53719525
45peptide cross-linking (GO:0018149)3.51624912
46intermediate filament cytoskeleton organization (GO:0045104)3.42230586
47atrioventricular valve morphogenesis (GO:0003181)3.40876183
48aromatic amino acid family catabolic process (GO:0009074)3.35557385
49negative regulation of cell fate specification (GO:0009996)3.35402654
50chemical homeostasis within a tissue (GO:0048875)3.33355210
51response to methylmercury (GO:0051597)3.30367427
52Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.30139744
53positive regulation of epidermal cell differentiation (GO:0045606)3.28356042
54myelin maintenance (GO:0043217)3.25256630
55intermediate filament-based process (GO:0045103)3.24027759
56apical protein localization (GO:0045176)3.23852140
57positive regulation of epidermis development (GO:0045684)3.22877498
58protein localization to endosome (GO:0036010)3.16607807
59skin morphogenesis (GO:0043589)3.16588636
60adherens junction assembly (GO:0034333)3.14948146
61regulation of establishment of planar polarity (GO:0090175)3.14698348
62limb bud formation (GO:0060174)3.13231868
63focal adhesion assembly (GO:0048041)3.10998160
64cell-substrate adherens junction assembly (GO:0007045)3.10998160
65ectoderm development (GO:0007398)3.09282174
66bile acid biosynthetic process (GO:0006699)3.06563391
67ventricular cardiac muscle cell action potential (GO:0086005)3.05332894
68regulation of heart rate by cardiac conduction (GO:0086091)3.03228520
69regulation of collateral sprouting (GO:0048670)3.03193765
70skin development (GO:0043588)2.99881374
71oligodendrocyte differentiation (GO:0048709)2.99643868
72presynaptic membrane organization (GO:0097090)2.98488501
73asymmetric protein localization (GO:0008105)2.98282309
74thioester biosynthetic process (GO:0035384)2.97933980
75acyl-CoA biosynthetic process (GO:0071616)2.97933980
76hemidesmosome assembly (GO:0031581)2.97628840
77heme transport (GO:0015886)2.96945364
78activation of Rac GTPase activity (GO:0032863)2.96110513
79negative regulation of epidermis development (GO:0045683)2.89946003
80layer formation in cerebral cortex (GO:0021819)2.89312238
81establishment of mitochondrion localization (GO:0051654)2.88936109
82synaptic vesicle docking involved in exocytosis (GO:0016081)2.88364596
83keratinization (GO:0031424)2.86600058
84maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85509431
85presynaptic membrane assembly (GO:0097105)2.83759541
86negative regulation of lipase activity (GO:0060192)2.83145966
87neuron remodeling (GO:0016322)2.83134987
88regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.81947772
89lateral sprouting from an epithelium (GO:0060601)2.80290623
90glutamate secretion (GO:0014047)2.77853265
91adherens junction organization (GO:0034332)2.77688640
92regulation of hair cycle (GO:0042634)2.76523158
93regulation of epidermis development (GO:0045682)2.76051590
94glutathione biosynthetic process (GO:0006750)2.73729022
95cell junction assembly (GO:0034329)2.73340239
96virion attachment to host cell (GO:0019062)2.72416923
97adhesion of symbiont to host cell (GO:0044650)2.72416923
98cell junction organization (GO:0034330)2.72358999
99glyoxylate metabolic process (GO:0046487)2.70293501
100L-serine transport (GO:0015825)2.69562890
101iron coordination entity transport (GO:1901678)2.69446407
102keratinocyte development (GO:0003334)2.69404363
103alpha-linolenic acid metabolic process (GO:0036109)2.69120075
104pyrimidine nucleobase catabolic process (GO:0006208)2.69038396
105establishment of skin barrier (GO:0061436)2.69015616
106isoprenoid biosynthetic process (GO:0008299)2.68936379
107amyloid precursor protein metabolic process (GO:0042982)2.68477757
108non-canonical Wnt signaling pathway (GO:0035567)2.67820325
109positive regulation of cellular amine metabolic process (GO:0033240)2.67168881
110positive regulation of keratinocyte differentiation (GO:0045618)2.67006864
111creatine metabolic process (GO:0006600)2.66924465
112negative regulation of neurotransmitter transport (GO:0051589)2.66629724
113regulation of cardioblast differentiation (GO:0051890)2.66082054
114glycerophospholipid catabolic process (GO:0046475)2.65192175
115hair cycle (GO:0042633)2.65138540
116molting cycle (GO:0042303)2.65138540
117negative regulation of cell fate commitment (GO:0010454)2.64665143
118coenzyme catabolic process (GO:0009109)2.61791682
119negative regulation of protein localization to cell surface (GO:2000009)2.61552793
120peptidyl-tyrosine autophosphorylation (GO:0038083)2.61486854
121convergent extension (GO:0060026)2.60627056
122regulation of fibrinolysis (GO:0051917)2.60571811
123mitotic G1 DNA damage checkpoint (GO:0031571)2.59901240
124protein retention in ER lumen (GO:0006621)2.59755867
125acyl-CoA metabolic process (GO:0006637)2.59100842
126thioester metabolic process (GO:0035383)2.59100842
127cholesterol metabolic process (GO:0008203)2.58555170
128intestinal epithelial cell development (GO:0060576)2.58494692
129negative regulation of axon extension involved in axon guidance (GO:0048843)2.58170587
130regulation of water loss via skin (GO:0033561)2.57953232
131establishment of apical/basal cell polarity (GO:0035089)2.57513239
132eye photoreceptor cell differentiation (GO:0001754)2.57221685
133photoreceptor cell differentiation (GO:0046530)2.57221685
134negative regulation of neurotransmitter secretion (GO:0046929)2.56656870
135regulation of short-term neuronal synaptic plasticity (GO:0048172)2.52006944
136bile acid metabolic process (GO:0008206)2.51454512
137nonribosomal peptide biosynthetic process (GO:0019184)2.50606475
138neuron cell-cell adhesion (GO:0007158)2.50513049
139response to phenylpropanoid (GO:0080184)2.50399308
140tyrosine metabolic process (GO:0006570)2.50022898
141positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.49763785
142regulation of keratinocyte differentiation (GO:0045616)2.49717962
143peptidyl-glutamic acid carboxylation (GO:0017187)2.49568906
144protein carboxylation (GO:0018214)2.49568906
145cellular potassium ion homeostasis (GO:0030007)2.49565786
146renal system development (GO:0072001)2.49414758
147cardiac conduction (GO:0061337)2.49391647
148establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.49242010
149cardiac right ventricle morphogenesis (GO:0003215)2.49088531
150response to lipoprotein particle (GO:0055094)2.48980853
151negative regulation of fibrinolysis (GO:0051918)2.48064173
152keratinocyte proliferation (GO:0043616)2.48058666
153negative regulation of chondrocyte differentiation (GO:0032331)2.47330584
154regulation of phospholipase A2 activity (GO:0032429)2.47082211
155G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.46666128
156positive regulation of hair cycle (GO:0042635)2.46213658
157positive regulation of hair follicle development (GO:0051798)2.46213658
158molting cycle process (GO:0022404)2.46172249
159hair cycle process (GO:0022405)2.46172249
160branching involved in salivary gland morphogenesis (GO:0060445)2.46019620
161G1 DNA damage checkpoint (GO:0044783)2.44569142
162fibrinolysis (GO:0042730)2.44567713
163peripheral nervous system axon ensheathment (GO:0032292)2.44267048
164myelination in peripheral nervous system (GO:0022011)2.44267048
165morphogenesis of embryonic epithelium (GO:0016331)2.43843449
166regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.43362330
167positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.43362330
168sterol metabolic process (GO:0016125)2.41119224
169regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.40474616
170regulation of cholesterol esterification (GO:0010872)2.40344118
171axon development (GO:0061564)2.40319057
172triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.40081684
173high-density lipoprotein particle remodeling (GO:0034375)2.37394536
174negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.36635681
175regulation of bile acid biosynthetic process (GO:0070857)2.35512282
176linoleic acid metabolic process (GO:0043651)2.34563145
177cholesterol efflux (GO:0033344)2.32672336
178sphingoid metabolic process (GO:0046519)2.32571569
179substantia nigra development (GO:0021762)2.31618370
180steroid biosynthetic process (GO:0006694)2.30677865
181positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.30623852
182dendritic spine morphogenesis (GO:0060997)2.30594761
183gamma-aminobutyric acid transport (GO:0015812)2.30476688
184cerebellar granule cell differentiation (GO:0021707)2.30336134
185regulation of lipoprotein metabolic process (GO:0050746)2.29554076
186regulation of cholesterol homeostasis (GO:2000188)2.28856112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.01976317
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.62905187
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29464601
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27610303
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25833947
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24349480
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20045729
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18037619
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14107330
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12557479
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.11378911
12RACK7_27058665_Chip-Seq_MCF-7_Human2.10678010
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.10246244
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.10246244
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.06861414
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02625162
17RXR_22158963_ChIP-Seq_LIVER_Mouse2.02153007
18GBX2_23144817_ChIP-Seq_PC3_Human2.01495858
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01305911
20LXR_22292898_ChIP-Seq_THP-1_Human1.99485875
21AR_21572438_ChIP-Seq_LNCaP_Human1.94546722
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93124331
23KDM2B_26808549_Chip-Seq_K562_Human1.89792805
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88575336
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87681581
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87177653
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85615277
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84629755
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.82645241
30EZH2_22144423_ChIP-Seq_EOC_Human1.80927242
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79409287
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77095957
33UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.74784234
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.73758871
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71643093
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.71017031
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.69238139
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68024167
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.67386993
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.64894415
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.63797049
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59368164
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.55922929
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54599603
45SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54599603
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54489612
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52844636
48TRIM28_21343339_ChIP-Seq_HEK293_Human1.48537914
49POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46606479
50P300_27058665_Chip-Seq_ZR-75-30cells_Human1.43536300
51CLOCK_20551151_ChIP-Seq_293T_Human1.43038779
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42856707
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42371373
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41359365
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.40896177
56ERG_21242973_ChIP-ChIP_JURKAT_Human1.40095607
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.39116480
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38131347
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38030062
60ATF3_27146783_Chip-Seq_COLON_Human1.37719690
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37548133
62TP63_22573176_ChIP-Seq_HFKS_Human1.37403513
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37294188
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35953968
65TAF15_26573619_Chip-Seq_HEK293_Human1.34610870
66CBX2_27304074_Chip-Seq_ESCs_Mouse1.33432121
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32654524
68SMC4_20622854_ChIP-Seq_HELA_Human1.31557379
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.30926798
70KDM2B_26808549_Chip-Seq_DND41_Human1.30284841
71SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30257486
72DROSHA_22980978_ChIP-Seq_HELA_Human1.29229761
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28324993
74EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27402708
75ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27355969
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27345991
77CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27275047
78SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26420892
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.25051033
80VDR_22108803_ChIP-Seq_LS180_Human1.24639820
81CREB1_26743006_Chip-Seq_LNCaP_Human1.24311311
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24289238
83TCF7_22412390_ChIP-Seq_EML_Mouse1.23957415
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23415197
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.22397600
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.21074360
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20708537
88AHR_22903824_ChIP-Seq_MCF-7_Human1.19731395
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17834283
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16954194
91TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16459731
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16347573
93SMAD3_21741376_ChIP-Seq_EPCs_Human1.15756849
94TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14909233
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14703956
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14588386
97SA1_27219007_Chip-Seq_ERYTHROID_Human1.13532462
98RING1B_27294783_Chip-Seq_NPCs_Mouse1.13204042
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12010943
100ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10825537
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10281306
102KLF5_25053715_ChIP-Seq_YYC3_Human1.09895510
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09638207
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.08559561
105TP53_20018659_ChIP-ChIP_R1E_Mouse1.07771289
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07400884
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.06644658
108MYC_22102868_ChIP-Seq_BL_Human1.06622058
109PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05954558
110P68_20966046_ChIP-Seq_HELA_Human1.05349205
111OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04299792
112SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03533173
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01569797
114WT1_25993318_ChIP-Seq_PODOCYTE_Human1.00615144
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00375362
116KAP1_27257070_Chip-Seq_ESCs_Mouse0.99996988
117CTCF_27219007_Chip-Seq_Bcells_Human0.98906052
118P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98714337
119RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98557811
120HTT_18923047_ChIP-ChIP_STHdh_Human0.97488622
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97279956
122SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97000218
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.96249069
124REST_21632747_ChIP-Seq_MESCs_Mouse0.96053772
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95476080
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94359433
127SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93490583
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.93003967
129TP53_18474530_ChIP-ChIP_U2OS_Human0.92207271
130CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92152990
131ZNF263_19887448_ChIP-Seq_K562_Human0.91665224
132EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90732244
133DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90728327
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89277779
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88965873
136MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88963777
137CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87769080
138SMAD3_21741376_ChIP-Seq_HESCs_Human0.87133416
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86670033
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86670033
141OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86429115
142REST_18959480_ChIP-ChIP_MESCs_Mouse0.86230257
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85588048
144P300_19829295_ChIP-Seq_ESCs_Human0.85579635
145CTCF_27219007_Chip-Seq_ERYTHROID_Human0.85508373
146TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85321368
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85172850
148CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84546713
149RNF2_27304074_Chip-Seq_NSC_Mouse0.84441095
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.83621548
151RARB_27405468_Chip-Seq_BRAIN_Mouse0.83402608
152AR_21909140_ChIP-Seq_LNCAP_Human0.82789064
153POU5F1_16518401_ChIP-PET_MESCs_Mouse0.82226481
154TP63_23658742_ChIP-Seq_EP156T_Human0.82125631
155AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81679157
156VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81217464
157FOXA2_19822575_ChIP-Seq_HepG2_Human0.80057603
158BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79875364
159ESR1_20079471_ChIP-ChIP_T-47D_Human0.79610991
160PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.78834074
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78433999
162SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78391630
163TP53_16413492_ChIP-PET_HCT116_Human0.78115855
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76899167
165SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76598617
166TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76553565
167GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76541370
168ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.75408191
169EP300_21415370_ChIP-Seq_HL-1_Mouse0.74145873
170WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.72894786
171RXR_22108803_ChIP-Seq_LS180_Human0.72564607

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier3.64068240
2MP0003705_abnormal_hypodermis_morpholog3.49087652
3MP0000579_abnormal_nail_morphology2.97894437
4MP0002254_reproductive_system_inflammat2.95601534
5MP0000920_abnormal_myelination2.78040397
6MP0002139_abnormal_hepatobiliary_system2.73982910
7MP0005360_urolithiasis2.73282250
8MP0004381_abnormal_hair_follicle2.72822658
9MP0003880_abnormal_central_pattern2.50192275
10MP0004264_abnormal_extraembryonic_tissu2.49787202
11MP0004270_analgesia2.45663396
12MP0000383_abnormal_hair_follicle2.43136230
13MP0005085_abnormal_gallbladder_physiolo2.39064157
14MP0003566_abnormal_cell_adhesion2.38874952
15MP0010678_abnormal_skin_adnexa2.33175865
16MP0000566_synostosis2.28107107
17MP0001346_abnormal_lacrimal_gland2.26494235
18MP0001849_ear_inflammation2.15528644
19MP0003329_amyloid_beta_deposits2.15447996
20MP0008875_abnormal_xenobiotic_pharmacok2.13814919
21MP0000647_abnormal_sebaceous_gland2.08944705
22MP0004885_abnormal_endolymph2.00401044
23MP0000467_abnormal_esophagus_morphology1.97859660
24MP0005501_abnormal_skin_physiology1.94374426
25MP0005365_abnormal_bile_salt1.79129869
26MP0002098_abnormal_vibrissa_morphology1.75766744
27MP0000762_abnormal_tongue_morphology1.74162580
28MP0003011_delayed_dark_adaptation1.73814255
29MP0005275_abnormal_skin_tensile1.70807136
30MP0003453_abnormal_keratinocyte_physiol1.67268280
31MP0003195_calcinosis1.65644307
32MP0009840_abnormal_foam_cell1.65346768
33MP0009053_abnormal_anal_canal1.65165802
34MP0000778_abnormal_nervous_system1.63378171
35MP0003950_abnormal_plasma_membrane1.58710413
36MP0003690_abnormal_glial_cell1.56978510
37MP0003806_abnormal_nucleotide_metabolis1.56632263
38MP0010771_integument_phenotype1.52614691
39MP0005451_abnormal_body_composition1.52281046
40MP0004782_abnormal_surfactant_physiolog1.50738466
41MP0003941_abnormal_skin_development1.46793067
42MP0001486_abnormal_startle_reflex1.46685908
43MP0009379_abnormal_foot_pigmentation1.43432448
44MP0004142_abnormal_muscle_tone1.42739706
45MP0005083_abnormal_biliary_tract1.42334413
46MP0003878_abnormal_ear_physiology1.42109843
47MP0005377_hearing/vestibular/ear_phenot1.42109843
48MP0002060_abnormal_skin_morphology1.41582853
49MP0009931_abnormal_skin_appearance1.37603910
50MP0004859_abnormal_synaptic_plasticity1.35613053
51MP0002272_abnormal_nervous_system1.34934265
52MP0003283_abnormal_digestive_organ1.34676471
53MP0005076_abnormal_cell_differentiation1.34258206
54MP0005551_abnormal_eye_electrophysiolog1.34104947
55MP0001216_abnormal_epidermal_layer1.33958484
56MP0005409_darkened_coat_color1.33109299
57MP0004742_abnormal_vestibular_system1.30812712
58MP0009780_abnormal_chondrocyte_physiolo1.29680285
59MP0005423_abnormal_somatic_nervous1.27780928
60MP0002064_seizures1.26642191
61MP0001340_abnormal_eyelid_morphology1.26638152
62MP0000427_abnormal_hair_cycle1.24585667
63MP0004272_abnormal_basement_membrane1.23603077
64MP0010234_abnormal_vibrissa_follicle1.23409438
65MP0000377_abnormal_hair_follicle1.23134888
66MP0002734_abnormal_mechanical_nocicepti1.22704706
67MP0003136_yellow_coat_color1.21557843
68MP0003634_abnormal_glial_cell1.21481452
69MP0003315_abnormal_perineum_morphology1.21075911
70MP0010352_gastrointestinal_tract_polyps1.21009136
71MP0001529_abnormal_vocalization1.20252063
72MP0003632_abnormal_nervous_system1.17429320
73MP0009672_abnormal_birth_weight1.17356082
74MP0003635_abnormal_synaptic_transmissio1.15322241
75MP0004947_skin_inflammation1.13651653
76MP0000678_abnormal_parathyroid_gland1.11794048
77MP0002089_abnormal_postnatal_growth/wei1.10877105
78MP0000604_amyloidosis1.10461673
79MP0001188_hyperpigmentation1.08287802
80MP0009046_muscle_twitch1.04705783
81MP0009745_abnormal_behavioral_response1.04511842
82MP0002229_neurodegeneration1.04419872
83MP0002822_catalepsy1.03727882
84MP0001666_abnormal_nutrient_absorption1.03051867
85MP0010329_abnormal_lipoprotein_level1.02653341
86MP0010030_abnormal_orbit_morphology1.00773643
87MP0000462_abnormal_digestive_system1.00565880
88MP0001348_abnormal_lacrimal_gland0.97848416
89MP0000367_abnormal_coat/_hair0.96964062
90MP0002118_abnormal_lipid_homeostasis0.96887307
91MP0000627_abnormal_mammary_gland0.95258620
92MP0001177_atelectasis0.95185694
93MP0003252_abnormal_bile_duct0.94119354
94MP0000955_abnormal_spinal_cord0.93979004
95MP0002063_abnormal_learning/memory/cond0.93872242
96MP0005023_abnormal_wound_healing0.93774908
97MP0003123_paternal_imprinting0.93425132
98MP0004019_abnormal_vitamin_homeostasis0.93249864
99MP0004185_abnormal_adipocyte_glucose0.92623615
100MP0001440_abnormal_grooming_behavior0.92121840
101MP0008789_abnormal_olfactory_epithelium0.90477240
102MP0002882_abnormal_neuron_morphology0.88931395
103MP0004858_abnormal_nervous_system0.88047821
104MP0002697_abnormal_eye_size0.87666286
105MP0005332_abnormal_amino_acid0.86564099
106MP0002572_abnormal_emotion/affect_behav0.86025367
107MP0005195_abnormal_posterior_eye0.85499158
108MP0000537_abnormal_urethra_morphology0.85239538
109MP0008260_abnormal_autophagy0.82066411
110MP0003938_abnormal_ear_development0.81054132
111MP0002249_abnormal_larynx_morphology0.80825264
112MP0002234_abnormal_pharynx_morphology0.79895691
113MP0005257_abnormal_intraocular_pressure0.79818250
114MP0003631_nervous_system_phenotype0.79509934
115MP0001905_abnormal_dopamine_level0.79365366
116MP0002752_abnormal_somatic_nervous0.78895452
117MP0002111_abnormal_tail_morphology0.78717637
118MP0002090_abnormal_vision0.78611592
119MP0002233_abnormal_nose_morphology0.78594328
120MP0001485_abnormal_pinna_reflex0.77473960
121MP0003755_abnormal_palate_morphology0.77166848
122MP0002733_abnormal_thermal_nociception0.77005054
123MP0008569_lethality_at_weaning0.75540102
124MP0001851_eye_inflammation0.75170674
125MP0005499_abnormal_olfactory_system0.74872574
126MP0005394_taste/olfaction_phenotype0.74872574
127MP0002184_abnormal_innervation0.73749477
128MP0001968_abnormal_touch/_nociception0.73648259
129MP0001299_abnormal_eye_distance/0.73612840
130MP0001191_abnormal_skin_condition0.73162121
131MP0004043_abnormal_pH_regulation0.72891364
132MP0001970_abnormal_pain_threshold0.71935036
133MP0004197_abnormal_fetal_growth/weight/0.69243731
134MP0003115_abnormal_respiratory_system0.65718676
135MP0003191_abnormal_cellular_cholesterol0.58443239
136MP0000428_abnormal_craniofacial_morphol0.57628883
137MP0000432_abnormal_head_morphology0.56403758
138MP0001730_embryonic_growth_arrest0.55361754
139MP0002177_abnormal_outer_ear0.54664569
140MP0003861_abnormal_nervous_system0.52550979
141MP0005248_abnormal_Harderian_gland0.50273065
142MP0002896_abnormal_bone_mineralization0.49666213
143MP0004233_abnormal_muscle_weight0.49438655
144MP0005623_abnormal_meninges_morphology0.48723513
145MP0002081_perinatal_lethality0.44495677
146MP0002085_abnormal_embryonic_tissue0.42583697
147MP0003119_abnormal_digestive_system0.41864958
148MP0002084_abnormal_developmental_patter0.41841073
149MP0002877_abnormal_melanocyte_morpholog0.39609137
150MP0003937_abnormal_limbs/digits/tail_de0.37881136
151MP0001243_abnormal_dermal_layer0.37861834

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)5.38390707
2Neurofibrillary tangles (HP:0002185)5.24052828
3Alopecia of scalp (HP:0002293)5.23804040
4Cerebral inclusion bodies (HP:0100314)4.23614869
5Intrahepatic cholestasis (HP:0001406)4.16555901
6Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.11387969
7Degeneration of the lateral corticospinal tracts (HP:0002314)4.11387969
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.97736926
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.94513795
10Congenital ichthyosiform erythroderma (HP:0007431)3.86623358
11Ridged nail (HP:0001807)3.77800699
12Abnormality of the corticospinal tract (HP:0002492)3.71452934
13Selective tooth agenesis (HP:0001592)3.58561121
14Hypotrichosis (HP:0001006)3.56949095
15Abnormal blistering of the skin (HP:0008066)3.48334453
16Sensory axonal neuropathy (HP:0003390)3.47535342
17Xanthomatosis (HP:0000991)3.43457820
18Absent eyelashes (HP:0000561)3.43340047
19Fragile nails (HP:0001808)3.38579976
20Oral leukoplakia (HP:0002745)3.23936305
21Deep venous thrombosis (HP:0002625)3.22459839
22Sparse scalp hair (HP:0002209)3.13421654
23Sparse eyelashes (HP:0000653)3.12426243
24Hyperlipoproteinemia (HP:0010980)3.00581170
25Increased IgE level (HP:0003212)2.99524217
26Natal tooth (HP:0000695)2.92145987
27Pterygium (HP:0001059)2.91163274
28Advanced eruption of teeth (HP:0006288)2.86422749
29Alacrima (HP:0000522)2.84613392
30Erythroderma (HP:0001019)2.83688930
31Epidermoid cyst (HP:0200040)2.83439816
32Intention tremor (HP:0002080)2.82649476
33Plantar hyperkeratosis (HP:0007556)2.76723995
34Erythema (HP:0010783)2.76559114
35Supranuclear gaze palsy (HP:0000605)2.76532164
36Hypoplasia of dental enamel (HP:0006297)2.71769454
37Prolonged partial thromboplastin time (HP:0003645)2.65746498
38Ankyloglossia (HP:0010296)2.62952650
39Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61168595
40Onion bulb formation (HP:0003383)2.58670881
41Coronal craniosynostosis (HP:0004440)2.55250212
42Hypobetalipoproteinemia (HP:0003563)2.53580047
43Palmoplantar keratoderma (HP:0000982)2.49563719
44Abnormality of the axillary hair (HP:0100134)2.47923887
45Abnormality of secondary sexual hair (HP:0009888)2.47923887
46Aplasia involving bones of the upper limbs (HP:0009823)2.47566264
47Aplasia of the phalanges of the hand (HP:0009802)2.47566264
48Aplasia involving bones of the extremities (HP:0009825)2.47566264
49Peripheral hypomyelination (HP:0007182)2.45675408
50Anonychia (HP:0001798)2.45000854
51Milia (HP:0001056)2.44338113
52Hypophosphatemic rickets (HP:0004912)2.38842999
53Termporal pattern (HP:0011008)2.36851455
54Insidious onset (HP:0003587)2.36851455
55Lip pit (HP:0100267)2.35374638
56Spastic gait (HP:0002064)2.34896490
57Fragile skin (HP:0001030)2.34422607
58Hypoplastic labia majora (HP:0000059)2.34061285
59Septate vagina (HP:0001153)2.32010116
60Myokymia (HP:0002411)2.31589447
61Woolly hair (HP:0002224)2.30392731
62Absent hair (HP:0002298)2.27551538
63Esophageal atresia (HP:0002032)2.23512696
64Blepharitis (HP:0000498)2.23452192
65Taurodontia (HP:0000679)2.23213058
66Abnormality of permanent molar morphology (HP:0011071)2.23213058
67Abnormality of the dental root (HP:0006486)2.23213058
68Hyporeflexia of lower limbs (HP:0002600)2.22059230
69Hypoplastic pelvis (HP:0008839)2.18522758
70Right ventricular cardiomyopathy (HP:0011663)2.17018090
71Onycholysis (HP:0001806)2.16909849
72Bifid scrotum (HP:0000048)2.13324576
73Hyperacusis (HP:0010780)2.11402668
74Dysmetria (HP:0001310)2.10249907
75Abnormality of the labia majora (HP:0012881)2.09477473
76Decreased lacrimation (HP:0000633)2.07264131
77Turricephaly (HP:0000262)2.06707347
78Aplasia cutis congenita (HP:0001057)2.06050094
79Palmoplantar hyperkeratosis (HP:0000972)2.05771478
80Thick nail (HP:0001805)2.05464230
81Abnormality of molar morphology (HP:0011070)2.05091190
82Abnormality of molar (HP:0011077)2.05091190
83Abnormality of the salivary glands (HP:0010286)2.02790160
84Laryngomalacia (HP:0001601)2.02420274
85Thickened helices (HP:0000391)2.02272503
86Bronchomalacia (HP:0002780)2.02197268
87Ankle clonus (HP:0011448)2.01892303
88Synostosis involving the elbow (HP:0003938)2.00160502
89Humeroradial synostosis (HP:0003041)2.00160502
90Cerebral hypomyelination (HP:0006808)1.98787522
91Corneal erosion (HP:0200020)1.98687859
92Morphological abnormality of the pyramidal tract (HP:0002062)1.98228741
93Nasolacrimal duct obstruction (HP:0000579)1.97114128
94Fat malabsorption (HP:0002630)1.96640248
95Abnormality of oral frenula (HP:0000190)1.96001701
96Oligodontia (HP:0000677)1.95705557
97Spastic paraparesis (HP:0002313)1.95337416
98Amyloidosis (HP:0011034)1.95132736
99Obstructive sleep apnea (HP:0002870)1.92660687
100Abnormality of the lacrimal duct (HP:0011481)1.92300095
101Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91764869
102Cupped ear (HP:0000378)1.91725927
103Ectropion (HP:0000656)1.91687488
104Akinesia (HP:0002304)1.90666313
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.90523609
106Septo-optic dysplasia (HP:0100842)1.90125635
107Popliteal pterygium (HP:0009756)1.89351402
108Abnormality of methionine metabolism (HP:0010901)1.89190009
109Rickets (HP:0002748)1.88705952
110Abnormality of the dental pulp (HP:0006479)1.87966877
111Abnormality of hair growth rate (HP:0011363)1.87781260
112Slow-growing hair (HP:0002217)1.87781260
113Abnormality of nail color (HP:0100643)1.87366346
114Megalencephaly (HP:0001355)1.86456298
115Carious teeth (HP:0000670)1.86208252
116Abnormality of the Achilles tendon (HP:0005109)1.85812883
117Scanning speech (HP:0002168)1.85586900
118Partial agenesis of the corpus callosum (HP:0001338)1.84768799
119Hypohidrosis (HP:0000966)1.84391912
120Leukodystrophy (HP:0002415)1.83939497
121Absent septum pellucidum (HP:0001331)1.83178036
122Abnormal hair laboratory examination (HP:0003328)1.82296707
123Conjugated hyperbilirubinemia (HP:0002908)1.82068480
124Palmar hyperkeratosis (HP:0010765)1.81163947
125Insomnia (HP:0100785)1.81150702
126Pili torti (HP:0003777)1.80707635
127Atrophic scars (HP:0001075)1.79122043
128Abnormal auditory evoked potentials (HP:0006958)1.77846429
129Conical tooth (HP:0000698)1.77649884
130Spastic tetraparesis (HP:0001285)1.77614989
131Abnormality of placental membranes (HP:0011409)1.76637327
132Amniotic constriction ring (HP:0009775)1.76637327
133Hyperventilation (HP:0002883)1.76348414
134Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.76234275
135Breast hypoplasia (HP:0003187)1.75961647
136Abnormality of the gastric mucosa (HP:0004295)1.74808956
137Severe Myopia (HP:0011003)1.73255484
138Brittle hair (HP:0002299)1.73213340
139Premature skin wrinkling (HP:0100678)1.73061748
140Multifactorial inheritance (HP:0001426)1.72422577
141Slow saccadic eye movements (HP:0000514)1.72074091
142Broad face (HP:0000283)1.71673298
143Infantile muscular hypotonia (HP:0008947)1.71651401
144Ventricular tachycardia (HP:0004756)1.71326687
145Labial hypoplasia (HP:0000066)1.70593240
146Split foot (HP:0001839)1.67839336
147Vascular calcification (HP:0004934)1.67797066
148Hypolipoproteinemia (HP:0010981)1.67689304
149Split hand (HP:0001171)1.67265537
150Abnormality of glycolysis (HP:0004366)1.67178325
151Increased serum pyruvate (HP:0003542)1.67178325
152Stridor (HP:0010307)1.66186562
153Neonatal death (HP:0003811)1.66113670
154Complement deficiency (HP:0004431)1.65945035
155Nail dystrophy (HP:0008404)1.65630994
156Abnormality of the fingernails (HP:0001231)1.65488823
157Hypoplastic female external genitalia (HP:0012815)1.62540701
158Germ cell neoplasia (HP:0100728)1.60324128
159Shallow orbits (HP:0000586)1.59954137
160Dry hair (HP:0011359)1.59603475
161Depressed nasal tip (HP:0000437)1.59075314
162Trismus (HP:0000211)1.58616942
163Abnormality of the nasolacrimal system (HP:0000614)1.54086081
164Curly hair (HP:0002212)1.51646547
165Acanthosis nigricans (HP:0000956)1.50361879
166Fatigable weakness (HP:0003473)1.49823300
167Abnormality of the neuromuscular junction (HP:0003398)1.49823300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.53580073
2RIPK13.61853006
3OXSR13.32046331
4SMG13.11118319
5TRIB33.05350428
6FGFR22.87011594
7PKN12.72222073
8CDK122.67146680
9EPHB12.61013014
10EEF2K2.54845437
11BCR2.46639994
12CASK2.44485497
13MARK12.25975312
14MET2.25165163
15ARAF2.22591072
16PBK1.85855056
17MAPKAPK51.85521144
18WNK41.84546534
19EPHA41.72776543
20CDK191.72232441
21NTRK11.69106134
22PDGFRA1.66060356
23MST1R1.58130937
24UHMK11.57270333
25NTRK21.55165753
26ICK1.54602414
27MAP3K101.50395970
28PAK61.50049912
29LIMK11.48970989
30MAPK151.48208973
31DYRK21.45460349
32STK241.43610090
33CSNK1G31.43465015
34CSNK1A1L1.42299448
35ERBB41.40175593
36FER1.40142416
37LMTK21.39112006
38PRKD31.35091438
39CAMK2B1.33913146
40MAP3K21.33591362
41TGFBR11.31934009
42CSNK1G11.25707265
43MST41.25338017
44SGK4941.24261068
45SGK2231.24261068
46TYRO31.23150398
47MAP3K91.20892258
48PAK41.18982383
49CSNK1G21.18570730
50FGR1.17068629
51ROCK21.16410518
52PNCK1.15774870
53MAPKAPK31.15647164
54DAPK21.15408886
55ERN11.12285069
56PAK31.10586518
57WNK11.10519525
58PKN21.08197850
59MAP3K61.04757871
60CAMK2G1.02027582
61RPS6KA21.01604928
62EPHB21.01064255
63RPS6KB20.98971675
64MTOR0.98921067
65CAMK2D0.95292152
66PTK60.93945251
67PHKG20.93928585
68PHKG10.93928585
69CAMK2A0.93119211
70CDK50.92233423
71MARK20.91044181
72CAMK1D0.90586890
73GSK3A0.88458644
74STK110.88456366
75PRPF4B0.87512482
76NEK60.86348023
77CAMK1G0.85354777
78TAOK10.85150857
79GRK50.81040643
80PRKCE0.80656438
81LATS10.80354450
82TESK10.79967619
83DMPK0.79471102
84PRKD10.79047912
85FGFR10.77231957
86FGFR40.76953938
87BRAF0.76433842
88SIK10.76048349
89GRK10.74038455
90CDK140.73396385
91LATS20.73154994
92STK380.71017918
93PIM20.70029474
94BMPR1B0.69116515
95EPHA20.68903691
96CDK150.65317834
97EPHA30.63694967
98PRKCZ0.62958502
99MAP2K20.62844749
100DYRK1A0.62295286
101BRD40.61471481
102TRPM70.60826292
103ALK0.60031123
104CDK180.59904767
105CSNK1D0.58338570
106TESK20.58119813
107PIK3CG0.57188457
108ERBB20.57147436
109CDK11A0.56816886
110TNIK0.56488216
111MAP3K130.55446811
112CLK10.53302355
113TAF10.53106456
114CDC42BPA0.52976322
115IRAK30.52623919
116PTK20.52208580
117CDK30.51901794
118NME10.51890293
119CDK70.51170166
120RET0.50924569
121DYRK1B0.50866791
122CSNK1E0.50030815
123MAP2K40.49282725
124MAP3K30.48921012
125MAP3K10.48886643
126PRKD20.48765604
127PRKCI0.47353187
128FYN0.47333199
129SGK30.46717080
130MINK10.46065160
131NTRK30.45495524
132PRKG10.45276632
133BMX0.45241297
134DDR20.44843249
135PLK20.44702482
136RPS6KB10.44687314
137MAP3K70.44529169
138PDPK10.43326185
139KSR20.42799841
140STK38L0.42048323
141INSRR0.41908410
142RPS6KA10.41695234
143GRK70.41668544
144DAPK10.41065825
145CSNK1A10.40939035
146MUSK0.40813860
147PRKCQ0.40491746
148KSR10.40193130
149RPS6KL10.39402653
150RPS6KC10.39402653
151MAPK100.38500726
152PDGFRB0.35716697
153TTN0.34658783
154FGFR30.34517705
155PRKCH0.34507229
156MAPK90.30785741
157PRKG20.29001755
158TTK0.28772615
159MAPK80.28735644
160HIPK20.26062966

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.44820828
2Steroid biosynthesis_Homo sapiens_hsa001003.32323562
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.11754535
4Nitrogen metabolism_Homo sapiens_hsa009103.06161149
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.97289332
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.94233541
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.75634703
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.62236613
9Histidine metabolism_Homo sapiens_hsa003402.26981162
10Butanoate metabolism_Homo sapiens_hsa006502.09999740
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04151046
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01224838
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00692060
14Notch signaling pathway_Homo sapiens_hsa043301.97391529
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91643625
16Adherens junction_Homo sapiens_hsa045201.75881696
17Thyroid cancer_Homo sapiens_hsa052161.74503503
18Ether lipid metabolism_Homo sapiens_hsa005651.71067276
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.70433680
20VEGF signaling pathway_Homo sapiens_hsa043701.66397125
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.64210262
22Sulfur metabolism_Homo sapiens_hsa009201.63759218
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.62423229
24Arginine biosynthesis_Homo sapiens_hsa002201.60127866
25Long-term potentiation_Homo sapiens_hsa047201.59991450
26Linoleic acid metabolism_Homo sapiens_hsa005911.57636974
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.56887918
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.55064435
29GnRH signaling pathway_Homo sapiens_hsa049121.54838349
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53993015
31Retinol metabolism_Homo sapiens_hsa008301.53016593
32Endometrial cancer_Homo sapiens_hsa052131.52675189
33Chemical carcinogenesis_Homo sapiens_hsa052041.52618243
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.50925900
35Glioma_Homo sapiens_hsa052141.50069250
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46069334
37Axon guidance_Homo sapiens_hsa043601.44731178
38Bladder cancer_Homo sapiens_hsa052191.43562221
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43422593
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.41861986
41Phenylalanine metabolism_Homo sapiens_hsa003601.40093852
42Tryptophan metabolism_Homo sapiens_hsa003801.38730788
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36829833
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.36439571
45Fatty acid metabolism_Homo sapiens_hsa012121.34308301
46Estrogen signaling pathway_Homo sapiens_hsa049151.32947663
47MicroRNAs in cancer_Homo sapiens_hsa052061.32206345
48Tyrosine metabolism_Homo sapiens_hsa003501.30361472
49Complement and coagulation cascades_Homo sapiens_hsa046101.30323571
50Amoebiasis_Homo sapiens_hsa051461.26696508
51Small cell lung cancer_Homo sapiens_hsa052221.26468256
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.23562478
53Proteoglycans in cancer_Homo sapiens_hsa052051.22157595
54Chronic myeloid leukemia_Homo sapiens_hsa052201.21919205
55Peroxisome_Homo sapiens_hsa041461.20907698
56Focal adhesion_Homo sapiens_hsa045101.16674546
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16349547
58Bile secretion_Homo sapiens_hsa049761.13919478
59Insulin signaling pathway_Homo sapiens_hsa049101.10107273
60beta-Alanine metabolism_Homo sapiens_hsa004101.08790936
61PPAR signaling pathway_Homo sapiens_hsa033201.07611698
62Fatty acid degradation_Homo sapiens_hsa000711.04480693
63Phototransduction_Homo sapiens_hsa047441.02857385
64GABAergic synapse_Homo sapiens_hsa047271.02067661
65Sphingolipid metabolism_Homo sapiens_hsa006000.99867100
66Inositol phosphate metabolism_Homo sapiens_hsa005620.97974315
67Choline metabolism in cancer_Homo sapiens_hsa052310.97836364
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97250083
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.97108030
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95705584
71Arginine and proline metabolism_Homo sapiens_hsa003300.94802836
72Glutamatergic synapse_Homo sapiens_hsa047240.92626871
73Wnt signaling pathway_Homo sapiens_hsa043100.92154516
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91178638
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.90839344
76Propanoate metabolism_Homo sapiens_hsa006400.90305771
77Non-small cell lung cancer_Homo sapiens_hsa052230.88702668
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88582663
79Gap junction_Homo sapiens_hsa045400.87603512
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87047255
81Fat digestion and absorption_Homo sapiens_hsa049750.86786166
82Acute myeloid leukemia_Homo sapiens_hsa052210.86217857
83Rap1 signaling pathway_Homo sapiens_hsa040150.85481527
84Vibrio cholerae infection_Homo sapiens_hsa051100.85149045
85Serotonergic synapse_Homo sapiens_hsa047260.84821979
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84671303
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84220208
88Amphetamine addiction_Homo sapiens_hsa050310.83792706
89Dilated cardiomyopathy_Homo sapiens_hsa054140.83366672
90ABC transporters_Homo sapiens_hsa020100.81989420
91Arachidonic acid metabolism_Homo sapiens_hsa005900.81211001
92Pancreatic secretion_Homo sapiens_hsa049720.80149796
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77927008
94Vitamin B6 metabolism_Homo sapiens_hsa007500.77910554
95Glutathione metabolism_Homo sapiens_hsa004800.75137351
96Pancreatic cancer_Homo sapiens_hsa052120.75073593
97Glucagon signaling pathway_Homo sapiens_hsa049220.72641967
98AMPK signaling pathway_Homo sapiens_hsa041520.72439330
99Nicotine addiction_Homo sapiens_hsa050330.71965688
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71677168
101Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70397748
102Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70199091
103Pathways in cancer_Homo sapiens_hsa052000.69627386
104Insulin secretion_Homo sapiens_hsa049110.69358485
105Hedgehog signaling pathway_Homo sapiens_hsa043400.69102394
106Endocytosis_Homo sapiens_hsa041440.68936761
107Fatty acid biosynthesis_Homo sapiens_hsa000610.68370595
108Prostate cancer_Homo sapiens_hsa052150.67992992
109Vitamin digestion and absorption_Homo sapiens_hsa049770.67657911
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67482233
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67285618
112Folate biosynthesis_Homo sapiens_hsa007900.66544067
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65693649
114Basal cell carcinoma_Homo sapiens_hsa052170.65081831
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61870035
116Ovarian steroidogenesis_Homo sapiens_hsa049130.61560565
117Long-term depression_Homo sapiens_hsa047300.61332243
118Thyroid hormone synthesis_Homo sapiens_hsa049180.61088051
119Oxidative phosphorylation_Homo sapiens_hsa001900.59506599
120Colorectal cancer_Homo sapiens_hsa052100.59185792
121Tight junction_Homo sapiens_hsa045300.58628826
122Oxytocin signaling pathway_Homo sapiens_hsa049210.57909037
123Caffeine metabolism_Homo sapiens_hsa002320.57570925
124mRNA surveillance pathway_Homo sapiens_hsa030150.57416534
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56952628
126Protein digestion and absorption_Homo sapiens_hsa049740.56874800
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.56869193
128mTOR signaling pathway_Homo sapiens_hsa041500.56200898
129cAMP signaling pathway_Homo sapiens_hsa040240.56198644
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55402125
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54619020
132Biosynthesis of amino acids_Homo sapiens_hsa012300.54028189
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.53768738
134Synaptic vesicle cycle_Homo sapiens_hsa047210.53340248
135Pyruvate metabolism_Homo sapiens_hsa006200.52752354
136Salivary secretion_Homo sapiens_hsa049700.52668016
137Staphylococcus aureus infection_Homo sapiens_hsa051500.51680530
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51083859
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.49475320
140Collecting duct acid secretion_Homo sapiens_hsa049660.49396768
141Cocaine addiction_Homo sapiens_hsa050300.48307437
142Morphine addiction_Homo sapiens_hsa050320.45097253
143Circadian entrainment_Homo sapiens_hsa047130.45074477
144Alzheimers disease_Homo sapiens_hsa050100.41896537
145Renin secretion_Homo sapiens_hsa049240.41095599
146Melanogenesis_Homo sapiens_hsa049160.40664567
147Mineral absorption_Homo sapiens_hsa049780.39599311
148Taste transduction_Homo sapiens_hsa047420.38179426
149Ras signaling pathway_Homo sapiens_hsa040140.36660890
150Gastric acid secretion_Homo sapiens_hsa049710.36289176
151ECM-receptor interaction_Homo sapiens_hsa045120.36197253
152Prion diseases_Homo sapiens_hsa050200.35464104
153ErbB signaling pathway_Homo sapiens_hsa040120.34947755
154Renal cell carcinoma_Homo sapiens_hsa052110.34116032
155Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33839430
156Metabolic pathways_Homo sapiens_hsa011000.32769527
157Sphingolipid signaling pathway_Homo sapiens_hsa040710.32032632
158Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31655618
159Vascular smooth muscle contraction_Homo sapiens_hsa042700.30277793
160Dorso-ventral axis formation_Homo sapiens_hsa043200.30205061
161Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.29877459
162Dopaminergic synapse_Homo sapiens_hsa047280.29274374
163Hippo signaling pathway_Homo sapiens_hsa043900.28872319
164Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28469366

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