NECTIN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.80126026
2sperm motility (GO:0030317)5.33537177
3fusion of sperm to egg plasma membrane (GO:0007342)5.19376314
4multicellular organism reproduction (GO:0032504)4.75409418
5cell wall macromolecule metabolic process (GO:0044036)4.72419356
6cell wall macromolecule catabolic process (GO:0016998)4.72419356
7epithelial cilium movement (GO:0003351)4.68079081
8paraxial mesoderm development (GO:0048339)4.52156213
9piRNA metabolic process (GO:0034587)4.51509547
10acrosome assembly (GO:0001675)4.48930881
11acrosome reaction (GO:0007340)4.46092948
12axonemal dynein complex assembly (GO:0070286)4.45142457
13sperm-egg recognition (GO:0035036)4.28919367
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.24240165
15cilium movement (GO:0003341)4.12015338
16motile cilium assembly (GO:0044458)4.00895307
17spermatid development (GO:0007286)4.00423320
18male meiosis (GO:0007140)3.97073052
19plasma membrane fusion (GO:0045026)3.90769100
20reproduction (GO:0000003)3.83115970
21binding of sperm to zona pellucida (GO:0007339)3.77714556
22erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.75412518
23L-phenylalanine catabolic process (GO:0006559)3.75412518
24cell-cell recognition (GO:0009988)3.64830859
25chondrocyte proliferation (GO:0035988)3.64043205
26notochord development (GO:0030903)3.50067702
27anterior/posterior axis specification, embryo (GO:0008595)3.46740683
28organic cation transport (GO:0015695)3.46217492
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.34736347
30L-phenylalanine metabolic process (GO:0006558)3.34736347
31response to pheromone (GO:0019236)3.34486110
32cell migration involved in sprouting angiogenesis (GO:0002042)3.27836446
33aromatic amino acid family catabolic process (GO:0009074)3.27033279
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.26320680
35axon extension involved in axon guidance (GO:0048846)3.26320680
36artery development (GO:0060840)3.20450930
37hormone catabolic process (GO:0042447)3.16037758
38mesenchymal-epithelial cell signaling (GO:0060638)3.12416852
39single fertilization (GO:0007338)3.10504976
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.10379583
41drug catabolic process (GO:0042737)3.09977275
42urea metabolic process (GO:0019627)3.09169762
43urea cycle (GO:0000050)3.09169762
44synaptonemal complex organization (GO:0070193)3.08042446
45cellular glucuronidation (GO:0052695)3.05856527
46hippo signaling (GO:0035329)3.05616546
47drug transmembrane transport (GO:0006855)3.04119060
48genitalia morphogenesis (GO:0035112)2.99207207
49DNA methylation involved in gamete generation (GO:0043046)2.99165832
50regulation of cilium movement (GO:0003352)2.98205417
51lymphangiogenesis (GO:0001946)2.96853048
52left/right pattern formation (GO:0060972)2.96680257
53homocysteine metabolic process (GO:0050667)2.96057852
54sperm capacitation (GO:0048240)2.93088719
55negative regulation of axon extension involved in axon guidance (GO:0048843)2.92264114
56regulation of bile acid biosynthetic process (GO:0070857)2.90186471
57synaptonemal complex assembly (GO:0007130)2.88706044
58tryptophan catabolic process (GO:0006569)2.86408961
59indole-containing compound catabolic process (GO:0042436)2.86408961
60indolalkylamine catabolic process (GO:0046218)2.86408961
61estrogen biosynthetic process (GO:0006703)2.83269032
62planar cell polarity pathway involved in neural tube closure (GO:0090179)2.82228660
63negative regulation of axon guidance (GO:1902668)2.81172301
64collagen fibril organization (GO:0030199)2.80709777
65nuclear pore complex assembly (GO:0051292)2.79054910
66fertilization (GO:0009566)2.78824416
67tryptophan metabolic process (GO:0006568)2.76027795
68inner ear receptor cell development (GO:0060119)2.75872465
69embryonic foregut morphogenesis (GO:0048617)2.74197213
70regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73967588
71negative regulation of DNA repair (GO:0045738)2.73893677
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72314116
73convergent extension (GO:0060026)2.72234724
74midgut development (GO:0007494)2.71374253
75spermatogenesis (GO:0007283)2.70756123
76cell adhesion mediated by integrin (GO:0033627)2.69917931
77glucuronate metabolic process (GO:0019585)2.69833179
78uronic acid metabolic process (GO:0006063)2.69833179
79male gamete generation (GO:0048232)2.69186528
80ventricular system development (GO:0021591)2.67958685
81ventricular cardiac muscle cell development (GO:0055015)2.67009555
82cellular response to vitamin D (GO:0071305)2.66656106
83negative regulation of inclusion body assembly (GO:0090084)2.65451966
84polyol transport (GO:0015791)2.64481489
85nitrogen cycle metabolic process (GO:0071941)2.64410930
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.62909893
87high-density lipoprotein particle remodeling (GO:0034375)2.61780358
88regulation of growth hormone secretion (GO:0060123)2.60538126
89glyoxylate metabolic process (GO:0046487)2.59541267
90bile acid and bile salt transport (GO:0015721)2.59135425
91mitotic metaphase plate congression (GO:0007080)2.58358052
92triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.57735247
93mitotic cytokinesis (GO:0000281)2.57187949
94sulfur amino acid catabolic process (GO:0000098)2.56883222
95regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.56355721
96bile acid biosynthetic process (GO:0006699)2.54779605
97gamete generation (GO:0007276)2.53690367
98mitotic sister chromatid cohesion (GO:0007064)2.53062913
99intestinal absorption (GO:0050892)2.52712760
100regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.51854771
101bile acid metabolic process (GO:0008206)2.51102176
102alpha-linolenic acid metabolic process (GO:0036109)2.50444141
103kidney mesenchyme development (GO:0072074)2.50185045
104heterochromatin organization (GO:0070828)2.49704222
105outer ear morphogenesis (GO:0042473)2.49581615
106reverse cholesterol transport (GO:0043691)2.48608862
107exogenous drug catabolic process (GO:0042738)2.48457731
108negative chemotaxis (GO:0050919)2.47083451
109lateral sprouting from an epithelium (GO:0060601)2.46693488
110regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.45838683
111amino-acid betaine metabolic process (GO:0006577)2.45294432
112negative regulation of keratinocyte proliferation (GO:0010839)2.45187933
113kynurenine metabolic process (GO:0070189)2.44668991
114peptidyl-glutamic acid modification (GO:0018200)2.44460243
115protein localization to kinetochore (GO:0034501)2.43559143
116acylglycerol homeostasis (GO:0055090)2.43471243
117triglyceride homeostasis (GO:0070328)2.43471243
118dorsal/ventral axis specification (GO:0009950)2.43107971
119cellular response to vitamin (GO:0071295)2.42528902
120endothelial cell morphogenesis (GO:0001886)2.41049035
121lung epithelium development (GO:0060428)2.40957051
122sequestering of extracellular ligand from receptor (GO:0035581)2.40361390
123surfactant homeostasis (GO:0043129)2.39512789
124glomerular visceral epithelial cell development (GO:0072015)2.39457889
125presynaptic membrane assembly (GO:0097105)2.39377113
126metaphase plate congression (GO:0051310)2.39280199
127appendage development (GO:0048736)2.39013248
128limb development (GO:0060173)2.39013248
129cytoskeleton-dependent cytokinesis (GO:0061640)2.38635798
130negative regulation of fibrinolysis (GO:0051918)2.38502123
131regulation of cell fate specification (GO:0042659)2.38454329
132negative regulation of chondrocyte differentiation (GO:0032331)2.37985044
133regulation of fibrinolysis (GO:0051917)2.37354482
134mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.37195006
135endodermal cell differentiation (GO:0035987)2.37097809
136negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.37061654
137nuclear pore organization (GO:0006999)2.37030750
138chromatin remodeling at centromere (GO:0031055)2.36894657
139Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.36579335
140intestinal cholesterol absorption (GO:0030299)2.36545763
141phospholipid efflux (GO:0033700)2.35601102
142microtubule depolymerization (GO:0007019)2.35545168
143mesodermal cell differentiation (GO:0048333)2.35545067
144cellular process involved in reproduction in multicellular organism (GO:0022412)2.34778671
145negative regulation of fibroblast apoptotic process (GO:2000270)2.34706884
146regulation of non-canonical Wnt signaling pathway (GO:2000050)2.34288763
147bone trabecula formation (GO:0060346)2.34130204
148germ cell development (GO:0007281)2.34118777
149CENP-A containing nucleosome assembly (GO:0034080)2.34052617
150response to follicle-stimulating hormone (GO:0032354)2.33705090
151tyrosine metabolic process (GO:0006570)2.33322933
152regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.33069247
153establishment of tissue polarity (GO:0007164)2.32980760
154establishment of planar polarity (GO:0001736)2.32980760
155regulation of establishment of planar polarity (GO:0090175)2.32529149
156positive regulation of glycolytic process (GO:0045821)2.31343215
157transepithelial transport (GO:0070633)2.29044506
158male meiosis I (GO:0007141)2.28498288
159skin morphogenesis (GO:0043589)2.28210483
160histone exchange (GO:0043486)2.27819870
161regulation of axon guidance (GO:1902667)2.27724594
162regulation of axon extension involved in axon guidance (GO:0048841)2.27253321
163establishment of integrated proviral latency (GO:0075713)2.26581145
164regulation of centriole replication (GO:0046599)2.25670946
165regulation of mitotic spindle organization (GO:0060236)2.25141334
166lung-associated mesenchyme development (GO:0060484)2.23855251
167substrate-dependent cell migration (GO:0006929)2.23348008
168metanephric mesenchyme development (GO:0072075)2.23298678
169chemical homeostasis within a tissue (GO:0048875)2.22581013
170intraciliary transport (GO:0042073)2.22479437
171mesenchymal cell differentiation (GO:0048762)2.22292231
172axon extension (GO:0048675)2.22275706
173calcium ion-dependent exocytosis (GO:0017156)2.21695457
174response to hepatocyte growth factor (GO:0035728)2.20673129
175cellular response to hepatocyte growth factor stimulus (GO:0035729)2.20673129
176cysteine metabolic process (GO:0006534)2.20631543
177pericardium development (GO:0060039)2.19974522
178linoleic acid metabolic process (GO:0043651)2.19167890
179sulfate transmembrane transport (GO:1902358)2.19047672
180apical protein localization (GO:0045176)2.18877427
181morphogenesis of an epithelial sheet (GO:0002011)2.18145860
182peptidyl-glutamic acid carboxylation (GO:0017187)2.18092509
183protein carboxylation (GO:0018214)2.18092509
184ventricular septum development (GO:0003281)2.18016574
185positive regulation of protein autophosphorylation (GO:0031954)2.17755531
186serine family amino acid catabolic process (GO:0009071)2.17501390
187chromosome condensation (GO:0030261)2.16880520
188establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.16737538
189cochlea morphogenesis (GO:0090103)2.16504636
190non-canonical Wnt signaling pathway (GO:0035567)2.16470445
191positive regulation of cardiac muscle cell proliferation (GO:0060045)2.14692179
192establishment of apical/basal cell polarity (GO:0035089)2.13205223
193negative regulation of embryonic development (GO:0045992)2.12565711
194positive regulation of cardiac muscle tissue development (GO:0055025)2.12409756
195substrate adhesion-dependent cell spreading (GO:0034446)2.12335716
196primitive streak formation (GO:0090009)2.10750605
197establishment of monopolar cell polarity (GO:0061162)2.10593639
198establishment or maintenance of monopolar cell polarity (GO:0061339)2.10593639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.04966970
2EZH2_22144423_ChIP-Seq_EOC_Human2.77668286
3FOXM1_23109430_ChIP-Seq_U2OS_Human2.56907911
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43934826
5WT1_19549856_ChIP-ChIP_CCG9911_Human2.34035159
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.32895285
7AR_21909140_ChIP-Seq_LNCAP_Human2.31853642
8GBX2_23144817_ChIP-Seq_PC3_Human2.16426678
9E2F7_22180533_ChIP-Seq_HELA_Human2.10821917
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.99351611
11BRD4_25478319_ChIP-Seq_HGPS_Human1.87852028
12LXR_22158963_ChIP-Seq_LIVER_Mouse1.83594473
13TAF15_26573619_Chip-Seq_HEK293_Human1.81618971
14VDR_22108803_ChIP-Seq_LS180_Human1.80314853
15HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77077760
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76868954
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76499973
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76267715
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.74893250
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73039708
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.72472245
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70999723
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70818824
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.68985906
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.68882780
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64756307
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63915717
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.63913483
29EWS_26573619_Chip-Seq_HEK293_Human1.63517049
30CJUN_26792858_Chip-Seq_BT549_Human1.63051845
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62878602
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61809663
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.59668502
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57604096
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56740427
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52395642
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52067678
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51451171
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49503621
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49410817
41FUS_26573619_Chip-Seq_HEK293_Human1.47284585
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46757389
43TBX3_20139965_ChIP-Seq_MESCs_Mouse1.46051287
44TBX3_20139965_ChIP-Seq_ESCs_Mouse1.45232380
45BCAT_22108803_ChIP-Seq_LS180_Human1.43690998
46SMAD4_21799915_ChIP-Seq_A2780_Human1.43680724
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43405975
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42909631
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.40971275
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39221007
51NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38464949
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38464949
53P300_19829295_ChIP-Seq_ESCs_Human1.37596055
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36418038
55TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.35660373
56KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.35125489
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32277921
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32026679
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31991430
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31599380
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31599380
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.31070208
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29831174
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29699200
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29477909
66EED_16625203_ChIP-ChIP_MESCs_Mouse1.29281756
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28732422
68TP53_16413492_ChIP-PET_HCT116_Human1.28506284
69PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28104710
70PPARA_22158963_ChIP-Seq_LIVER_Mouse1.27696725
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.27522283
72STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26862697
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.26304586
74STAT3_23295773_ChIP-Seq_U87_Human1.26173200
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.24810429
76EZH2_27304074_Chip-Seq_ESCs_Mouse1.24596398
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.23882603
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.23367349
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.23314313
80ZNF274_21170338_ChIP-Seq_K562_Hela1.22437351
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22281886
82NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.21323024
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.20094747
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19615861
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19487367
86P53_22387025_ChIP-Seq_ESCs_Mouse1.19189559
87KDM2B_26808549_Chip-Seq_REH_Human1.18465219
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17302741
89RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17246921
90FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17020755
91RNF2_27304074_Chip-Seq_NSC_Mouse1.16909795
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16607127
93SOX9_26525672_Chip-Seq_HEART_Mouse1.16274080
94TCF4_18268006_ChIP-ChIP_LS174T_Human1.15799441
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15467481
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15375649
97AHR_22903824_ChIP-Seq_MCF-7_Human1.15202005
98EP300_21415370_ChIP-Seq_HL-1_Mouse1.15033085
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.14929412
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14739161
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14287450
102TAL1_26923725_Chip-Seq_HPCs_Mouse1.13882746
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.13690749
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13145879
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.12309025
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12256673
107TCF4_23295773_ChIP-Seq_U87_Human1.11773342
108NANOG_16153702_ChIP-ChIP_HESCs_Human1.11045817
109IGF1R_20145208_ChIP-Seq_DFB_Human1.10540776
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10192975
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.09718975
112CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09567181
113TP53_18474530_ChIP-ChIP_U2OS_Human1.09025433
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08968424
115SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08452672
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08135626
117TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07961937
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07619810
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.07443570
120PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06351894
121AR_25329375_ChIP-Seq_VCAP_Human1.06026150
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05854212
123TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05464480
124EZH2_27294783_Chip-Seq_ESCs_Mouse1.05099076
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04941236
126TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04888956
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04862158
128P300_18555785_Chip-Seq_ESCs_Mouse1.04686761
129OCT4_18555785_Chip-Seq_ESCs_Mouse1.03903495
130ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03783175
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02939070
132CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02450424
133TP63_19390658_ChIP-ChIP_HaCaT_Human1.01991077
134JUN_21703547_ChIP-Seq_K562_Human1.01849918
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01765200
136SOX2_16153702_ChIP-ChIP_HESCs_Human1.00956389
137TBL1_22424771_ChIP-Seq_293T_Human1.00924150
138EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00820200
139ELK1_19687146_ChIP-ChIP_HELA_Human1.00739977
140CBP_20019798_ChIP-Seq_JUKART_Human1.00671035
141IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00442232
142SMAD_19615063_ChIP-ChIP_OVARY_Human1.00416280
143PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00369792
144FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99272653
145TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97816981
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97756262
147GF1B_26923725_Chip-Seq_HPCs_Mouse0.96771565
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95659800
149CDX2_22108803_ChIP-Seq_LS180_Human0.95422701
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94117515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.72545107
2MP0005360_urolithiasis4.47670531
3MP0002139_abnormal_hepatobiliary_system4.28669943
4MP0005085_abnormal_gallbladder_physiolo3.48027729
5MP0005365_abnormal_bile_salt3.40001691
6MP0008438_abnormal_cutaneous_collagen3.35250303
7MP0003252_abnormal_bile_duct2.91950934
8MP0000566_synostosis2.84310741
9MP0008875_abnormal_xenobiotic_pharmacok2.66129593
10MP0010352_gastrointestinal_tract_polyps2.41030321
11MP0005623_abnormal_meninges_morphology2.10195435
12MP0009780_abnormal_chondrocyte_physiolo2.06369455
13MP0003698_abnormal_male_reproductive1.85366977
14MP0003283_abnormal_digestive_organ1.82310208
15MP0009053_abnormal_anal_canal1.78977359
16MP0002234_abnormal_pharynx_morphology1.75743384
17MP0003868_abnormal_feces_composition1.71625645
18MP0005248_abnormal_Harderian_gland1.71262107
19MP0003195_calcinosis1.70989999
20MP0004043_abnormal_pH_regulation1.68258336
21MP0001929_abnormal_gametogenesis1.67853313
22MP0004019_abnormal_vitamin_homeostasis1.63712461
23MP0003941_abnormal_skin_development1.62648185
24MP0000428_abnormal_craniofacial_morphol1.56312338
25MP0000462_abnormal_digestive_system1.48571885
26MP0003950_abnormal_plasma_membrane1.47702668
27MP0010329_abnormal_lipoprotein_level1.42570042
28MP0005257_abnormal_intraocular_pressure1.42094000
29MP0000678_abnormal_parathyroid_gland1.41065036
30MP0002249_abnormal_larynx_morphology1.40267524
31MP0010368_abnormal_lymphatic_system1.35653128
32MP0000579_abnormal_nail_morphology1.32474104
33MP0001666_abnormal_nutrient_absorption1.32211594
34MP0002653_abnormal_ependyma_morphology1.31595308
35MP0009250_abnormal_appendicular_skeleto1.30913052
36MP0002138_abnormal_hepatobiliary_system1.30118144
37MP0003566_abnormal_cell_adhesion1.28044409
38MP0002084_abnormal_developmental_patter1.26477835
39MP0001958_emphysema1.25021716
40MP0004264_abnormal_extraembryonic_tissu1.24677102
41MP0009384_cardiac_valve_regurgitation1.24601967
42MP0002233_abnormal_nose_morphology1.24200646
43MP0003942_abnormal_urinary_system1.23256169
44MP0001879_abnormal_lymphatic_vessel1.21586828
45MP0001299_abnormal_eye_distance/1.20852169
46MP0003122_maternal_imprinting1.20607354
47MP0002697_abnormal_eye_size1.19836880
48MP0005332_abnormal_amino_acid1.17625219
49MP0005451_abnormal_body_composition1.17144971
50MP0003937_abnormal_limbs/digits/tail_de1.16699325
51MP0004957_abnormal_blastocyst_morpholog1.16456543
52MP0003136_yellow_coat_color1.15604855
53MP0001293_anophthalmia1.15497762
54MP0006054_spinal_hemorrhage1.14878107
55MP0002085_abnormal_embryonic_tissue1.14703366
56MP0002282_abnormal_trachea_morphology1.14655931
57MP0003115_abnormal_respiratory_system1.13922889
58MP0004272_abnormal_basement_membrane1.13288949
59MP0008932_abnormal_embryonic_tissue1.12184820
60MP0000537_abnormal_urethra_morphology1.11905519
61MP0006292_abnormal_olfactory_placode1.11723488
62MP0002161_abnormal_fertility/fecundity1.10818018
63MP0003279_aneurysm1.09934350
64MP0005646_abnormal_pituitary_gland1.07227233
65MP0005187_abnormal_penis_morphology1.06290773
66MP0003119_abnormal_digestive_system1.05836921
67MP0002210_abnormal_sex_determination1.04919328
68MP0000013_abnormal_adipose_tissue1.03811592
69MP0010030_abnormal_orbit_morphology1.03795018
70MP0009697_abnormal_copulation1.03025635
71MP0000049_abnormal_middle_ear1.02621621
72MP0003755_abnormal_palate_morphology1.02258608
73MP0003091_abnormal_cell_migration1.01040234
74MP0003890_abnormal_embryonic-extraembry1.00875544
75MP0000534_abnormal_ureter_morphology1.00329258
76MP0002896_abnormal_bone_mineralization1.00134508
77MP0002928_abnormal_bile_duct0.98551305
78MP0005197_abnormal_uvea_morphology0.98446508
79MP0009703_decreased_birth_body0.98360627
80MP0005508_abnormal_skeleton_morphology0.97554088
81MP0003718_maternal_effect0.95880091
82MP0001177_atelectasis0.95449095
83MP0005220_abnormal_exocrine_pancreas0.94661914
84MP0002111_abnormal_tail_morphology0.93164422
85MP0003121_genomic_imprinting0.92858426
86MP0000432_abnormal_head_morphology0.92753270
87MP0000653_abnormal_sex_gland0.92653424
88MP0003861_abnormal_nervous_system0.91939237
89MP0005647_abnormal_sex_gland0.91000370
90MP0003935_abnormal_craniofacial_develop0.90336560
91MP0000631_abnormal_neuroendocrine_gland0.89712137
92MP0002102_abnormal_ear_morphology0.89496186
93MP0005275_abnormal_skin_tensile0.89291425
94MP0001145_abnormal_male_reproductive0.89186568
95MP0005023_abnormal_wound_healing0.88688770
96MP0003385_abnormal_body_wall0.87173113
97MP0002751_abnormal_autonomic_nervous0.86748399
98MP0001346_abnormal_lacrimal_gland0.86610239
99MP0002796_impaired_skin_barrier0.86556910
100MP0005670_abnormal_white_adipose0.86349949
101MP0008877_abnormal_DNA_methylation0.86297368
102MP0002116_abnormal_craniofacial_bone0.86192584
103MP0010234_abnormal_vibrissa_follicle0.85526163
104MP0000569_abnormal_digit_pigmentation0.84919044
105MP0003806_abnormal_nucleotide_metabolis0.84614304
106MP0000163_abnormal_cartilage_morphology0.84536013
107MP0003123_paternal_imprinting0.84398616
108MP0002118_abnormal_lipid_homeostasis0.83410173
109MP0001765_abnormal_ion_homeostasis0.82667821
110MP0005503_abnormal_tendon_morphology0.82256434
111MP0006276_abnormal_autonomic_nervous0.82253666
112MP0000767_abnormal_smooth_muscle0.81601633
113MP0003705_abnormal_hypodermis_morpholog0.81491945
114MP0001944_abnormal_pancreas_morphology0.81450023
115MP0002295_abnormal_pulmonary_circulatio0.81117744
116MP0001286_abnormal_eye_development0.81030548
117MP0000778_abnormal_nervous_system0.79942393
118MP0001984_abnormal_olfaction0.79902697
119MP0000762_abnormal_tongue_morphology0.79496034
120MP0002177_abnormal_outer_ear0.78726649
121MP0000026_abnormal_inner_ear0.78670499
122MP0000647_abnormal_sebaceous_gland0.78262337
123MP0002932_abnormal_joint_morphology0.76971549
124MP0004782_abnormal_surfactant_physiolog0.76872713
125MP0000751_myopathy0.76400029
126MP0002081_perinatal_lethality0.76326119
127MP0005380_embryogenesis_phenotype0.76173864
128MP0001672_abnormal_embryogenesis/_devel0.76173864
129MP0002092_abnormal_eye_morphology0.75882386
130MP0004197_abnormal_fetal_growth/weight/0.75651879
131MP0009379_abnormal_foot_pigmentation0.75430776
132MP0003878_abnormal_ear_physiology0.73644596
133MP0005377_hearing/vestibular/ear_phenot0.73644596
134MP0000613_abnormal_salivary_gland0.73389007
135MP0009672_abnormal_birth_weight0.72876401
136MP0002109_abnormal_limb_morphology0.71979190
137MP0005595_abnormal_vascular_smooth0.71930895
138MP0002938_white_spotting0.71691439
139MP0001697_abnormal_embryo_size0.71316972
140MP0003111_abnormal_nucleus_morphology0.71259177
141MP0001340_abnormal_eyelid_morphology0.71216892
142MP0002098_abnormal_vibrissa_morphology0.70557289
143MP0000733_abnormal_muscle_development0.70539849
144MP0003936_abnormal_reproductive_system0.70448874
145MP0005171_absent_coat_pigmentation0.70141490
146MP0005408_hypopigmentation0.69223979
147MP0005395_other_phenotype0.69173278
148MP0010307_abnormal_tumor_latency0.68585429
149MP0004133_heterotaxia0.68494987
150MP0002108_abnormal_muscle_morphology0.68044878
151MP0003984_embryonic_growth_retardation0.67983703

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.85821223
2Absent/shortened dynein arms (HP:0200106)5.86697566
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.86697566
4Chronic bronchitis (HP:0004469)4.72906794
5Abnormal respiratory motile cilium physiology (HP:0012261)4.64342410
6Premature rupture of membranes (HP:0001788)4.37703718
7Abnormal respiratory epithelium morphology (HP:0012253)3.79995266
8Abnormal respiratory motile cilium morphology (HP:0005938)3.79995266
9Rhinitis (HP:0012384)3.66421920
10Abnormal ciliary motility (HP:0012262)3.47156260
11Protrusio acetabuli (HP:0003179)3.43901809
12Intrahepatic cholestasis (HP:0001406)3.34829485
13Tubulointerstitial nephritis (HP:0001970)3.26401695
14Ankle contracture (HP:0006466)3.13833667
15Deep venous thrombosis (HP:0002625)2.98210107
16Abnormality of dentin (HP:0010299)2.85305785
17Vascular tortuosity (HP:0004948)2.85233029
18Hyperinsulinemic hypoglycemia (HP:0000825)2.84155823
19Neonatal short-limb short stature (HP:0008921)2.83823370
20Hypoglycemic seizures (HP:0002173)2.83268145
21Conjugated hyperbilirubinemia (HP:0002908)2.82946674
22Aortic dissection (HP:0002647)2.78417149
23Abnormality of the renal medulla (HP:0100957)2.77389147
24Broad metatarsal (HP:0001783)2.76842331
25Infertility (HP:0000789)2.76680139
26Arterial tortuosity (HP:0005116)2.70530520
27Nephronophthisis (HP:0000090)2.68198742
28Hepatoblastoma (HP:0002884)2.67798604
29Abnormality of glutamine family amino acid metabolism (HP:0010902)2.65761206
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.65725063
31Shallow orbits (HP:0000586)2.64650225
32Hypobetalipoproteinemia (HP:0003563)2.63498670
33Soft skin (HP:0000977)2.53682737
34Tubulointerstitial abnormality (HP:0001969)2.51122288
35Aortic aneurysm (HP:0004942)2.50467910
36Abnormality of aromatic amino acid family metabolism (HP:0004338)2.46617701
37Enlarged kidneys (HP:0000105)2.44723804
38Epidermoid cyst (HP:0200040)2.42572578
39Symptomatic seizures (HP:0011145)2.41531672
40Hypoglycemic coma (HP:0001325)2.40353303
41Septo-optic dysplasia (HP:0100842)2.37981120
42Tubular atrophy (HP:0000092)2.33656618
43Abnormality of the renal cortex (HP:0011035)2.33431673
44Hyperactive renin-angiotensin system (HP:0000841)2.26856683
45Chronic hepatic failure (HP:0100626)2.23863421
46Widely patent fontanelles and sutures (HP:0004492)2.21258605
47Absent eyebrow (HP:0002223)2.20884167
48Hypoplastic labia majora (HP:0000059)2.19387296
49Male infertility (HP:0003251)2.14552035
50Overgrowth (HP:0001548)2.13626762
51Prolonged partial thromboplastin time (HP:0003645)2.13271273
52Midline defect of the nose (HP:0004122)2.12831503
53Follicular hyperkeratosis (HP:0007502)2.10212385
54Hypolipoproteinemia (HP:0010981)2.07729298
55Atrophic scars (HP:0001075)2.06661285
56Potter facies (HP:0002009)2.04491877
57Facial shape deformation (HP:0011334)2.04491877
58Abnormality of the labia majora (HP:0012881)2.03175534
59Wide anterior fontanel (HP:0000260)2.02653837
60Hyperglycemia (HP:0003074)1.97932648
61Partial duplication of the phalanx of hand (HP:0009999)1.97524000
62Abnormality of the ischium (HP:0003174)1.96284863
63Papillary thyroid carcinoma (HP:0002895)1.94156440
64Renal dysplasia (HP:0000110)1.92231613
65Preaxial foot polydactyly (HP:0001841)1.91518476
66Wormian bones (HP:0002645)1.91430211
67Vascular calcification (HP:0004934)1.91256351
68Abnormality of renal excretion (HP:0011036)1.90792977
69Xanthomatosis (HP:0000991)1.90686623
70Bladder diverticulum (HP:0000015)1.89891106
71Tubulointerstitial fibrosis (HP:0005576)1.89536986
72Cystic liver disease (HP:0006706)1.88820303
73Hyperkalemia (HP:0002153)1.88321920
74Cardiovascular calcification (HP:0011915)1.87209885
75Hypoalphalipoproteinemia (HP:0003233)1.84976497
76Fibular hypoplasia (HP:0003038)1.84067861
77Fat malabsorption (HP:0002630)1.83526211
78Myelomeningocele (HP:0002475)1.82285402
79Spinal rigidity (HP:0003306)1.82070803
80Vertebral clefting (HP:0008428)1.81094898
81Abnormal lung lobation (HP:0002101)1.81028160
82Molar tooth sign on MRI (HP:0002419)1.79540889
83Abnormality of midbrain morphology (HP:0002418)1.79540889
84Abnormality of the phalanges of the hallux (HP:0010057)1.79288802
85Bell-shaped thorax (HP:0001591)1.78289124
86Chorioretinal atrophy (HP:0000533)1.78281022
87Anophthalmia (HP:0000528)1.78183183
88Limb-girdle muscle weakness (HP:0003325)1.76896808
89Partial duplication of thumb phalanx (HP:0009944)1.76864579
90Bowel diverticulosis (HP:0005222)1.76410305
91Abnormal urine output (HP:0012590)1.75620580
92Mitral valve prolapse (HP:0001634)1.75482947
93Abnormality of chloride homeostasis (HP:0011422)1.74622293
94Abnormality of proline metabolism (HP:0010907)1.72791737
95Hydroxyprolinuria (HP:0003080)1.72791737
96Osteomalacia (HP:0002749)1.72655769
97Cortical dysplasia (HP:0002539)1.72178874
98Ketosis (HP:0001946)1.71832028
99Abnormality of purine metabolism (HP:0004352)1.71678183
100Occipital encephalocele (HP:0002085)1.71548489
101Bronchiectasis (HP:0002110)1.70956915
102Omphalocele (HP:0001539)1.70053698
103Bifid tongue (HP:0010297)1.69709432
104Limited hip movement (HP:0008800)1.69610849
105Cutaneous syndactyly (HP:0012725)1.69072604
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68739212
107Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.67734559
108Coronal craniosynostosis (HP:0004440)1.67581549
109Polydipsia (HP:0001959)1.66691220
110Abnormal drinking behavior (HP:0030082)1.66691220
111Renal cortical cysts (HP:0000803)1.66575983
112Ketoacidosis (HP:0001993)1.64601900
113Broad long bones (HP:0005622)1.62559900
114Bile duct proliferation (HP:0001408)1.60970465
115Abnormal biliary tract physiology (HP:0012439)1.60970465
116Cervical subluxation (HP:0003308)1.60750036
117Capillary hemangiomas (HP:0005306)1.60600395
118Maternal diabetes (HP:0009800)1.60042914
119Morphological abnormality of the middle ear (HP:0008609)1.59210165
120Short 4th metacarpal (HP:0010044)1.58437257
121Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.58437257
122Fragile skin (HP:0001030)1.57663612
123Slender build (HP:0001533)1.57332686
124Rickets (HP:0002748)1.57037435
125Hyperextensible skin (HP:0000974)1.57023729
126Short hallux (HP:0010109)1.56917128
127Neoplasm of the tracheobronchial system (HP:0100552)1.56881199
128Abnormality of aspartate family amino acid metabolism (HP:0010899)1.56872411
129Abnormality of the septum pellucidum (HP:0007375)1.56592935
130Type 1 muscle fiber predominance (HP:0003803)1.56462021
131Short nail (HP:0001799)1.56396010
132Congenital hepatic fibrosis (HP:0002612)1.55294118
133Joint laxity (HP:0001388)1.55247508
134Bilateral microphthalmos (HP:0007633)1.54737531
135Malnutrition (HP:0004395)1.54205619
136Embryonal renal neoplasm (HP:0011794)1.54100681
137Aplasia of the phalanges of the hand (HP:0009802)1.54003053
138Aplasia involving bones of the extremities (HP:0009825)1.54003053
139Aplasia involving bones of the upper limbs (HP:0009823)1.54003053
140Abnormality of the labia minora (HP:0012880)1.53804997
141Insulin-resistant diabetes mellitus (HP:0000831)1.53643128
142Intestinal atresia (HP:0011100)1.53549305
143Optic nerve hypoplasia (HP:0000609)1.53379343
144Polyuria (HP:0000103)1.53088879
145Stage 5 chronic kidney disease (HP:0003774)1.52631387
146Absent septum pellucidum (HP:0001331)1.52221561
147Aplasia/Hypoplasia of the fibula (HP:0006492)1.51997472
148Alveolar cell carcinoma (HP:0006519)1.51983982
149Duplication of thumb phalanx (HP:0009942)1.51636918
150Cutaneous finger syndactyly (HP:0010554)1.51516628
151Arnold-Chiari malformation (HP:0002308)1.50940498
152Hypoventilation (HP:0002791)1.50876265
153Vertebral arch anomaly (HP:0008438)1.50130815
154Increased purine levels (HP:0004368)1.49701964
155Hyperuricemia (HP:0002149)1.49701964
156Delayed gross motor development (HP:0002194)1.49551783
157Postaxial foot polydactyly (HP:0001830)1.49490399
158Nephroblastoma (Wilms tumor) (HP:0002667)1.49391504
159Gout (HP:0001997)1.48992949
160Ulnar bowing (HP:0003031)1.48387688
161Medial flaring of the eyebrow (HP:0010747)1.48082206
162Supernumerary spleens (HP:0009799)1.47858404
163Hypoplasia of dental enamel (HP:0006297)1.47618464
164Genu recurvatum (HP:0002816)1.47525435
165Abnormality of sulfur amino acid metabolism (HP:0004339)1.47412855
166Renal duplication (HP:0000075)1.47237999
167Protruding ear (HP:0000411)1.47190243
168Hepatocellular carcinoma (HP:0001402)1.47089000
169Camptodactyly of toe (HP:0001836)1.46514704
170Blue sclerae (HP:0000592)1.45492749
171Abnormality of the distal phalanx of the thumb (HP:0009617)1.44916802
172Knee flexion contracture (HP:0006380)1.44360032
173Pulmonic stenosis (HP:0001642)1.44033616
174Hypoplastic ischia (HP:0003175)1.43996076
175Abnormality of the middle phalanges of the toes (HP:0010183)1.43645358
176Gastrointestinal atresia (HP:0002589)1.42809753
177Abnormal delivery (HP:0001787)1.41551756
178Osteolytic defects of the hand bones (HP:0009699)1.40616921
179Osteolytic defects of the phalanges of the hand (HP:0009771)1.40616921
180Broad phalanx (HP:0006009)1.40052025
181Aplasia/Hypoplasia of the sternum (HP:0006714)1.38857499
182Turricephaly (HP:0000262)1.38066238
183Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.37491500
184Broad thumb (HP:0011304)1.37476367
185Facial cleft (HP:0002006)1.36273514
186Increased nuchal translucency (HP:0010880)1.36022266
187Aplasia/Hypoplasia of the hallux (HP:0008362)1.35724408
188Missing ribs (HP:0000921)1.35337669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD34.30162291
2PDK44.12269960
3PDK34.12269960
4INSRR3.42265226
5LATS13.41725843
6TNIK2.72853093
7PDK22.70662402
8STK38L2.64630330
9WNK42.44729936
10FRK2.34760045
11EPHB22.31761940
12MKNK22.09769699
13TESK12.02962471
14ERBB41.97839178
15ICK1.94830186
16WEE11.90084234
17STK391.85665295
18CDC71.85110293
19BUB11.75372636
20WNK31.68344353
21PLK31.66874888
22MAPK151.64164159
23BRSK21.61366275
24STK31.56709164
25AKT31.54327177
26MYLK1.49985770
27CASK1.43250725
28PNCK1.42634410
29TSSK61.41976291
30MKNK11.39127424
31DDR21.29911555
32SIK11.29660026
33KSR11.20006635
34PTK2B1.17220255
35DMPK1.17164885
36MAP3K21.17156639
37NEK91.17028535
38TRIM281.16994299
39PAK31.16501979
40ACVR1B1.12802475
41BCR1.11385643
42PAK21.11374149
43STK381.10729717
44TAF11.09264604
45NEK11.07216981
46PLK11.05508244
47PASK1.03845593
48MST41.03163957
49LATS21.00938398
50NUAK11.00504032
51MAP3K40.99708122
52MAP3K100.98365422
53PBK0.96693562
54WNK10.93665315
55SGK20.93359805
56LIMK10.91937502
57DYRK1B0.91446805
58BRD40.88591160
59FGFR20.88556744
60ERBB20.88470911
61NTRK30.88162749
62EPHA20.85723018
63FER0.85374696
64CAMK1G0.84265059
65BMPR20.83532073
66OXSR10.82688141
67MET0.82486804
68SGK2230.82342497
69SGK4940.82342497
70PAK40.82292208
71CDK120.78463398
72EPHA40.77670913
73SRPK10.75551742
74LMTK20.74835502
75PTK20.74500599
76MOS0.74373995
77NEK60.72711842
78ROCK20.72626308
79MAPK130.70117221
80MST1R0.69414351
81PLK20.67987590
82BRSK10.67525772
83CDK30.66396169
84RIPK10.66371074
85AURKB0.64016380
86IRAK10.63424107
87STK240.63299974
88PLK40.63223630
89PDGFRA0.60550564
90SGK30.60455924
91PIK3CA0.60347691
92PRKAA10.60192690
93NTRK10.59942734
94TTK0.59562858
95CHEK20.58182201
96MAP2K70.58147408
97CSNK1G10.57988380
98GSK3A0.56949507
99FGFR10.54878754
100PAK60.54139329
101MARK30.53594448
102TTN0.52853706
103PTK60.52176001
104CAMK1D0.50537919
105TAOK30.50461201
106PRKD20.50038241
107ERBB30.49636271
108TGFBR20.49441996
109MAP3K120.47999995
110NLK0.47278625
111MARK10.47266197
112PRKCZ0.47083556
113MTOR0.46842275
114ATM0.46371547
115EPHA30.46288206
116ZAK0.46174414
117PRKAA20.44976794
118CDK80.44924320
119NTRK20.43907421
120EIF2AK20.43305448
121CHEK10.43039425
122VRK10.42431877
123MAP2K40.42289847
124BMPR1B0.41773393
125STK160.40973776
126KDR0.40745624
127CSNK1G20.40530211
128IRAK20.39859504
129TIE10.39819682
130MAP3K30.39741319
131CSNK1A1L0.38966026
132TYRO30.38551880
133PRKCE0.38379697
134CCNB10.38274084
135NEK20.38084416
136YES10.37925023
137EIF2AK30.37553905
138PDGFRB0.37390685
139PINK10.37329679
140CDK70.37074845
141BRAF0.36796611
142DYRK30.36544195
143SGK10.36524181
144FLT30.35623427
145PRKG20.35293409
146PRKCG0.35019885
147MELK0.34941669
148MAP2K10.32811917
149DYRK1A0.32618997
150ROCK10.31309670
151CSNK1E0.30947422

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.92515760
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94189522
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.83044424
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.53037432
5Sulfur metabolism_Homo sapiens_hsa009202.34133990
6Tryptophan metabolism_Homo sapiens_hsa003802.06337014
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06223081
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.01486821
9Selenocompound metabolism_Homo sapiens_hsa004501.92042689
10Arginine biosynthesis_Homo sapiens_hsa002201.91935349
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89938035
12Fatty acid degradation_Homo sapiens_hsa000711.87798844
13Steroid hormone biosynthesis_Homo sapiens_hsa001401.76973872
14Protein export_Homo sapiens_hsa030601.71165721
15Butanoate metabolism_Homo sapiens_hsa006501.67272749
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67201957
17Bile secretion_Homo sapiens_hsa049761.66625055
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.65736183
19Non-homologous end-joining_Homo sapiens_hsa034501.64091776
20Propanoate metabolism_Homo sapiens_hsa006401.62513263
21Retinol metabolism_Homo sapiens_hsa008301.59870719
22Chemical carcinogenesis_Homo sapiens_hsa052041.59296457
23Focal adhesion_Homo sapiens_hsa045101.57883086
24Cell cycle_Homo sapiens_hsa041101.56693517
25Histidine metabolism_Homo sapiens_hsa003401.54969395
26PPAR signaling pathway_Homo sapiens_hsa033201.54907544
27Complement and coagulation cascades_Homo sapiens_hsa046101.52170450
28Peroxisome_Homo sapiens_hsa041461.52079318
29Fatty acid biosynthesis_Homo sapiens_hsa000611.45967594
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45858333
31Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41989309
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41441911
33Fatty acid metabolism_Homo sapiens_hsa012121.39888946
34Pyruvate metabolism_Homo sapiens_hsa006201.37031376
35Fat digestion and absorption_Homo sapiens_hsa049751.35806744
36Vitamin digestion and absorption_Homo sapiens_hsa049771.35779491
37Proteoglycans in cancer_Homo sapiens_hsa052051.31622388
38Steroid biosynthesis_Homo sapiens_hsa001001.28085728
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27506862
40Starch and sucrose metabolism_Homo sapiens_hsa005001.27469584
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26988019
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25720407
43Basal transcription factors_Homo sapiens_hsa030221.22192087
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19128028
45MicroRNAs in cancer_Homo sapiens_hsa052061.18554442
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18146870
47Linoleic acid metabolism_Homo sapiens_hsa005911.15848957
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14979184
49Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12115023
50ABC transporters_Homo sapiens_hsa020101.11952344
51Basal cell carcinoma_Homo sapiens_hsa052171.10278947
52Mineral absorption_Homo sapiens_hsa049781.10045489
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09894803
54RNA transport_Homo sapiens_hsa030131.09302429
55Glucagon signaling pathway_Homo sapiens_hsa049221.06958652
56Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06566194
57p53 signaling pathway_Homo sapiens_hsa041151.04208527
58Lysine degradation_Homo sapiens_hsa003101.02920767
59Mismatch repair_Homo sapiens_hsa034301.02254328
60Dorso-ventral axis formation_Homo sapiens_hsa043201.02183157
61Thyroid cancer_Homo sapiens_hsa052160.99752921
62PI3K-Akt signaling pathway_Homo sapiens_hsa041510.97474943
63Insulin secretion_Homo sapiens_hsa049110.96839241
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94987592
65Nucleotide excision repair_Homo sapiens_hsa034200.94532119
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94284695
67Vitamin B6 metabolism_Homo sapiens_hsa007500.93993912
68Phenylalanine metabolism_Homo sapiens_hsa003600.93551417
69beta-Alanine metabolism_Homo sapiens_hsa004100.93507818
70Melanoma_Homo sapiens_hsa052180.92766453
71Hedgehog signaling pathway_Homo sapiens_hsa043400.92339120
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92159755
73Tyrosine metabolism_Homo sapiens_hsa003500.91936184
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91159779
75Fanconi anemia pathway_Homo sapiens_hsa034600.90831435
76Dilated cardiomyopathy_Homo sapiens_hsa054140.90021955
77Pathways in cancer_Homo sapiens_hsa052000.85658897
78Gap junction_Homo sapiens_hsa045400.85301633
79Oocyte meiosis_Homo sapiens_hsa041140.82314600
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82103211
81N-Glycan biosynthesis_Homo sapiens_hsa005100.81578859
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.80547580
83Protein digestion and absorption_Homo sapiens_hsa049740.78432427
84Small cell lung cancer_Homo sapiens_hsa052220.78226992
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77997443
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77301289
87Renin-angiotensin system_Homo sapiens_hsa046140.76440582
88Adherens junction_Homo sapiens_hsa045200.72414790
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72225057
90Glycerolipid metabolism_Homo sapiens_hsa005610.71556334
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71340439
92mRNA surveillance pathway_Homo sapiens_hsa030150.70559515
93Hippo signaling pathway_Homo sapiens_hsa043900.69709936
94Glutathione metabolism_Homo sapiens_hsa004800.68159587
95Thyroid hormone synthesis_Homo sapiens_hsa049180.66179971
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.66066330
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65396800
98DNA replication_Homo sapiens_hsa030300.62388539
99Arginine and proline metabolism_Homo sapiens_hsa003300.60953920
100Amphetamine addiction_Homo sapiens_hsa050310.58712613
101Fatty acid elongation_Homo sapiens_hsa000620.58323050
102One carbon pool by folate_Homo sapiens_hsa006700.58213182
103Wnt signaling pathway_Homo sapiens_hsa043100.57934623
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57881870
105Axon guidance_Homo sapiens_hsa043600.56670506
106Rap1 signaling pathway_Homo sapiens_hsa040150.56431224
107Ether lipid metabolism_Homo sapiens_hsa005650.54008536
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51529238
109RNA degradation_Homo sapiens_hsa030180.51074792
110Tight junction_Homo sapiens_hsa045300.50286901
111Ovarian steroidogenesis_Homo sapiens_hsa049130.49767877
112Homologous recombination_Homo sapiens_hsa034400.49631468
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.49117771
114Renin secretion_Homo sapiens_hsa049240.48403859
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46729515
116Melanogenesis_Homo sapiens_hsa049160.45302940
117Colorectal cancer_Homo sapiens_hsa052100.44325003
118RNA polymerase_Homo sapiens_hsa030200.42026891
119TGF-beta signaling pathway_Homo sapiens_hsa043500.41768000
120Taste transduction_Homo sapiens_hsa047420.40788843
121Spliceosome_Homo sapiens_hsa030400.40520654
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40150756
123ECM-receptor interaction_Homo sapiens_hsa045120.39900587
124Circadian rhythm_Homo sapiens_hsa047100.39148705
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.38922290
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38621937
127Type II diabetes mellitus_Homo sapiens_hsa049300.38510832
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.38280878
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.35785166
130Sphingolipid metabolism_Homo sapiens_hsa006000.35656746
131Amoebiasis_Homo sapiens_hsa051460.35621582
132Insulin resistance_Homo sapiens_hsa049310.34714772
133Arachidonic acid metabolism_Homo sapiens_hsa005900.33857580
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32297729
135Cocaine addiction_Homo sapiens_hsa050300.31770724
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29883663
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29867120
138Carbon metabolism_Homo sapiens_hsa012000.29341782
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.28728212
140Prostate cancer_Homo sapiens_hsa052150.28072884
141Metabolic pathways_Homo sapiens_hsa011000.25527477
142Caffeine metabolism_Homo sapiens_hsa002320.24356153
143Folate biosynthesis_Homo sapiens_hsa007900.24347431
144Estrogen signaling pathway_Homo sapiens_hsa049150.22348135

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »