NECTIN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.70803605
2molting cycle (GO:0042303)8.77452259
3hair cycle (GO:0042633)8.77452259
4keratinocyte differentiation (GO:0030216)7.02261289
5hemidesmosome assembly (GO:0031581)6.75885428
6multicellular organismal water homeostasis (GO:0050891)6.71138130
7intermediate filament organization (GO:0045109)6.40442126
8bundle of His cell to Purkinje myocyte communication (GO:0086069)6.23155253
9sphingoid metabolic process (GO:0046519)6.18599818
10peptide cross-linking (GO:0018149)6.00144309
11epidermal cell differentiation (GO:0009913)5.62270265
12water homeostasis (GO:0030104)5.60841604
13sphingosine metabolic process (GO:0006670)5.37120855
14keratinocyte proliferation (GO:0043616)5.25175950
15epidermis development (GO:0008544)5.15237138
16detection of bacterium (GO:0016045)5.07027783
17skin morphogenesis (GO:0043589)4.96622318
18diol metabolic process (GO:0034311)4.94831474
19interferon-gamma secretion (GO:0072643)4.58212011
20regulation of ruffle assembly (GO:1900027)4.57508856
21detection of other organism (GO:0098543)4.55281706
22polarized epithelial cell differentiation (GO:0030859)4.30125890
23regulation of keratinocyte differentiation (GO:0045616)4.12787272
24ectoderm development (GO:0007398)4.10701888
25regulation of chemokine secretion (GO:0090196)4.10231807
26calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.08753397
27keratinocyte development (GO:0003334)4.02181672
28intermediate filament cytoskeleton organization (GO:0045104)3.94586216
29regulation of phospholipase A2 activity (GO:0032429)3.94354008
30long-chain fatty acid biosynthetic process (GO:0042759)3.92135593
31regulation of keratinocyte proliferation (GO:0010837)3.86812596
32intermediate filament-based process (GO:0045103)3.84302383
33positive regulation of epidermal cell differentiation (GO:0045606)3.68743007
34regulation of cell proliferation involved in kidney development (GO:1901722)3.63713853
35glucosamine-containing compound catabolic process (GO:1901072)3.60909670
36G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.60164745
37axonemal dynein complex assembly (GO:0070286)3.60061612
38regulation of hypersensitivity (GO:0002883)3.49007687
39regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.47825514
40regulation of natural killer cell differentiation (GO:0032823)3.44928929
41positive regulation of keratinocyte differentiation (GO:0045618)3.43942231
42negative regulation of cell fate specification (GO:0009996)3.42738028
43epithelial cell maturation (GO:0002070)3.41292596
44negative regulation of stress fiber assembly (GO:0051497)3.38870417
45positive regulation of interleukin-8 secretion (GO:2000484)3.34287689
46chemical homeostasis within a tissue (GO:0048875)3.34044145
47lateral sprouting from an epithelium (GO:0060601)3.33999048
48cyclooxygenase pathway (GO:0019371)3.33697720
49lung lobe morphogenesis (GO:0060463)3.33039859
50positive regulation of chemokine secretion (GO:0090197)3.23598386
51regulation of epidermis development (GO:0045682)3.20646673
52regulation of clathrin-mediated endocytosis (GO:2000369)3.19178889
53virion attachment to host cell (GO:0019062)3.19010278
54adhesion of symbiont to host cell (GO:0044650)3.19010278
55phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.18082771
56phospholipid scrambling (GO:0017121)3.17948015
57gap junction assembly (GO:0016264)3.17411855
58cardiac right ventricle morphogenesis (GO:0003215)3.17233012
59cornea development in camera-type eye (GO:0061303)3.16067509
60negative regulation of transcription by competitive promoter binding (GO:0010944)3.13216847
61surfactant homeostasis (GO:0043129)3.12299749
62positive regulation of hair cycle (GO:0042635)3.11695726
63positive regulation of hair follicle development (GO:0051798)3.11695726
64atrioventricular valve morphogenesis (GO:0003181)3.10608412
65pyrimidine-containing compound transmembrane transport (GO:0072531)3.10037665
66lipoxygenase pathway (GO:0019372)3.06337870
67negative regulation of keratinocyte proliferation (GO:0010839)3.04770845
68endocrine hormone secretion (GO:0060986)3.04115261
69ventricular cardiac muscle cell action potential (GO:0086005)3.02273586
70fatty acid elongation (GO:0030497)3.02037435
71apical protein localization (GO:0045176)3.01984908
72cellular response to interferon-alpha (GO:0035457)2.99071846
73positive regulation of monocyte chemotaxis (GO:0090026)2.98980034
74tight junction assembly (GO:0070830)2.96521183
75regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94667990
76epithelial cell differentiation involved in prostate gland development (GO:0060742)2.94398474
77cilium or flagellum-dependent cell motility (GO:0001539)2.94103952
78hair follicle development (GO:0001942)2.92056088
79cell-cell junction assembly (GO:0007043)2.91928161
80regulation of epidermal cell differentiation (GO:0045604)2.90281742
81phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.89105146
82negative regulation of interferon-gamma production (GO:0032689)2.87619317
83regulation of interleukin-8 secretion (GO:2000482)2.86823829
84regulation of glomerular filtration (GO:0003093)2.84430530
85regulation of transforming growth factor beta1 production (GO:0032908)2.81822382
86gland morphogenesis (GO:0022612)2.81764100
87primary alcohol catabolic process (GO:0034310)2.81590503
88cilium movement (GO:0003341)2.79957175
89regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.79495610
90epithelial cell-cell adhesion (GO:0090136)2.76746580
91vitamin transmembrane transport (GO:0035461)2.73165627
92negative regulation of kidney development (GO:0090185)2.72796863
93phosphatidylcholine acyl-chain remodeling (GO:0036151)2.72347570
94detection of external biotic stimulus (GO:0098581)2.72270840
95lung epithelium development (GO:0060428)2.71081968
96axoneme assembly (GO:0035082)2.69929998
97positive regulation of antigen processing and presentation (GO:0002579)2.69463745
98negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.66496218
99negative regulation of cell fate commitment (GO:0010454)2.66350235
100hair follicle morphogenesis (GO:0031069)2.65266712
101linoleic acid metabolic process (GO:0043651)2.65005059
102positive regulation of epidermis development (GO:0045684)2.64805142
103epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63916554
104phosphatidylinositol acyl-chain remodeling (GO:0036149)2.63169588
105one-carbon compound transport (GO:0019755)2.62449481
106regulation of heart rate by cardiac conduction (GO:0086091)2.61737653
107mammary gland epithelial cell differentiation (GO:0060644)2.60730851
108regulation of hair follicle development (GO:0051797)2.59500821
109iron ion import (GO:0097286)2.57622594
110retinol metabolic process (GO:0042572)2.56117085
111branching involved in labyrinthine layer morphogenesis (GO:0060670)2.55812029
112antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55135182
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55135182
114asymmetric protein localization (GO:0008105)2.54548173
115epithelium development (GO:0060429)2.53812165
116diterpenoid biosynthetic process (GO:0016102)2.52217602
117genitalia morphogenesis (GO:0035112)2.51680867
118ear development (GO:0043583)2.49632467
119transepithelial transport (GO:0070633)2.49120779
120mammary gland epithelial cell proliferation (GO:0033598)2.48907568
121sympathetic nervous system development (GO:0048485)2.48808529
122face development (GO:0060324)2.48265310
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.47643872
124phosphatidylserine acyl-chain remodeling (GO:0036150)2.44660069
125ER overload response (GO:0006983)2.44250289
126negative regulation of interleukin-2 production (GO:0032703)2.43098210
127establishment of planar polarity (GO:0001736)2.40328685
128establishment of tissue polarity (GO:0007164)2.40328685
129purinergic nucleotide receptor signaling pathway (GO:0035590)2.40021051
130negative regulation of T cell mediated immunity (GO:0002710)2.39519828
131positive regulation of Cdc42 GTPase activity (GO:0043089)2.39287880
132adhesion of symbiont to host (GO:0044406)2.38282906
133intestinal epithelial cell development (GO:0060576)2.37774320
134planar cell polarity pathway involved in neural tube closure (GO:0090179)2.37724959
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37319889
136antigen processing and presentation of endogenous antigen (GO:0019883)2.36717809
137positive regulation of glomerulus development (GO:0090193)2.36503782
138wound healing, spreading of epidermal cells (GO:0035313)2.35300069
139heart valve morphogenesis (GO:0003179)2.33097040
140eyelid development in camera-type eye (GO:0061029)2.32900914
141skin development (GO:0043588)2.32674963
142glomerular visceral epithelial cell development (GO:0072015)2.31739523
143molting cycle process (GO:0022404)2.29732283
144hair cycle process (GO:0022405)2.29732283
145detection of biotic stimulus (GO:0009595)2.27629108
146regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.27210995
147regulation of monocyte chemotaxis (GO:0090025)2.27002627
148negative regulation of actin filament bundle assembly (GO:0032232)2.26586982
149long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.24565225
150positive regulation of mitochondrial membrane permeability (GO:0035794)2.23739277
151desmosome organization (GO:0002934)13.7404829
152establishment of skin barrier (GO:0061436)10.3664693
153keratinization (GO:0031424)10.1691518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.54738271
2ESR1_21235772_ChIP-Seq_MCF-7_Human2.77855451
3P63_26484246_Chip-Seq_KERATINOCYTES_Human2.77318482
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.66337799
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.26531407
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.24727890
7SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.01788943
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.01788943
9TP63_17297297_ChIP-ChIP_HaCaT_Human13.6178969
10TRIM28_21343339_ChIP-Seq_HEK293_Human1.93696764
11FOXO3_23340844_ChIP-Seq_DLD1_Human1.83866714
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.79846664
13ZNF263_19887448_ChIP-Seq_K562_Human1.75043590
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.68528483
15SOX2_20726797_ChIP-Seq_SW620_Human1.67565833
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59977817
17AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.52786446
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47534176
19ELF5_23300383_ChIP-Seq_T47D_Human1.47096249
20TP63_23658742_ChIP-Seq_EP156T_Human1.46291202
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.43439689
22TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42176039
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.39707152
24AHR_22903824_ChIP-Seq_MCF-7_Human1.39118791
25CJUN_26792858_Chip-Seq_BT549_Human1.36999657
26TP53_18474530_ChIP-ChIP_U2OS_Human1.31901590
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.30561021
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.30396689
29FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.30325016
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.28690777
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28211202
32KLF5_25053715_ChIP-Seq_YYC3_Human1.26609267
33BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23293709
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20394216
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19741234
36KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18893104
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.16788740
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15966844
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15092929
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14626492
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14314900
42ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14189892
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13953808
44GATA4_25053715_ChIP-Seq_YYC3_Human1.13539893
45VDR_22108803_ChIP-Seq_LS180_Human1.09097774
46RACK7_27058665_Chip-Seq_MCF-7_Human1.07855306
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.07423708
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06969532
49AR_21572438_ChIP-Seq_LNCaP_Human1.06798169
50RXR_22108803_ChIP-Seq_LS180_Human1.06442186
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.06277456
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.06188427
53TP63_22573176_ChIP-Seq_HFKS_Human1.05242114
54GATA3_24758297_ChIP-Seq_MCF-7_Human1.04860650
55ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.04775996
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04724408
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04023852
58ESR1_20079471_ChIP-ChIP_T-47D_Human1.03908801
59HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03304975
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.02211374
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.02107308
62HOXB7_26014856_ChIP-Seq_BT474_Human1.01850097
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00718140
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00299843
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.00029132
66CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96863466
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96691932
68TP53_20018659_ChIP-ChIP_R1E_Mouse0.96107952
69SUZ12_27294783_Chip-Seq_ESCs_Mouse0.94564404
70CDX2_22108803_ChIP-Seq_LS180_Human0.94512233
71SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94329039
72GATA1_22025678_ChIP-Seq_K562_Human0.93864847
73GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93286407
74RBPJ_21746931_ChIP-Seq_IB4_Human0.93142425
75CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91988731
76ATF3_27146783_Chip-Seq_COLON_Human0.91894364
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90928736
78UBF1/2_26484160_Chip-Seq_HMECs_Human0.90831204
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89977769
80PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88108960
81GATA6_25053715_ChIP-Seq_YYC3_Human0.88102231
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87095755
83HNFA_21074721_ChIP-Seq_CACO-2_Human0.87093626
84SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86718992
85AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86697876
86CHD1_26751641_Chip-Seq_LNCaP_Human0.86505444
87EGR1_19032775_ChIP-ChIP_M12_Human0.86042537
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.85769144
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.84356290
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82754527
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.82654193
92ETV1_20927104_ChIP-Seq_GIST48_Human0.82434203
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82261271
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81396822
95TCF4_22108803_ChIP-Seq_LS180_Human0.81368896
96BCAT_22108803_ChIP-Seq_LS180_Human0.81011527
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79499328
98CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79261788
99GATA6_21074721_ChIP-Seq_CACO-2_Human0.78922219
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.78085085
101NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78038535
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78038535
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.77093126
104LXR_22292898_ChIP-Seq_THP-1_Human0.76987149
105EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76747290
106IRF8_27001747_Chip-Seq_BMDM_Mouse0.76255191
107SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76146568
108FOXM1_26456572_ChIP-Seq_MCF-7_Human0.75820354
109FOXA2_19822575_ChIP-Seq_HepG2_Human0.75384477
110RXR_22158963_ChIP-Seq_LIVER_Mouse0.75280499
111SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.74097834
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.73603462
113RNF2_27304074_Chip-Seq_ESCs_Mouse0.73565661
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73437647
115CEBPB_22108803_ChIP-Seq_LS180_Human0.73369261
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.72658782
117PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.72548369
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.72418463
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.70862152
120EZH2_27294783_Chip-Seq_ESCs_Mouse0.70612289
121P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.70418733
122CBX2_22325352_ChIP-Seq_293T-Rex_Human0.69816555
123PHF8_20622853_ChIP-Seq_HELA_Human0.69792681
124EED_16625203_ChIP-ChIP_MESCs_Mouse0.68695940
125ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68022161
126SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.67660076
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.67640612
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.67526748
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.66569689
130FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66445638
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.66001185
132KDM2B_26808549_Chip-Seq_K562_Human0.65950986
133EZH2_27304074_Chip-Seq_ESCs_Mouse0.65015109
134EZH2_18974828_ChIP-Seq_MESCs_Mouse0.64932747
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.64932747
136CLOCK_20551151_ChIP-Seq_293T_Human0.64661365
137ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.64190571
138SA1_27219007_Chip-Seq_ERYTHROID_Human0.62893765
139TBL1_22424771_ChIP-Seq_293T_Human0.61760122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.29948532
2MP0010234_abnormal_vibrissa_follicle7.03291169
3MP0005275_abnormal_skin_tensile5.52173994
4MP0005501_abnormal_skin_physiology4.44856710
5MP0000579_abnormal_nail_morphology4.21528527
6MP0003941_abnormal_skin_development3.85718887
7MP0004381_abnormal_hair_follicle3.77426455
8MP0002098_abnormal_vibrissa_morphology3.75601987
9MP0010678_abnormal_skin_adnexa3.45047560
10MP0001216_abnormal_epidermal_layer3.31000803
11MP0002254_reproductive_system_inflammat3.30800622
12MP0002060_abnormal_skin_morphology3.08411181
13MP0000383_abnormal_hair_follicle3.04462375
14MP0000647_abnormal_sebaceous_gland3.01337807
15MP0003453_abnormal_keratinocyte_physiol2.87312213
16MP0010771_integument_phenotype2.80254363
17MP0000377_abnormal_hair_follicle2.71800410
18MP0004947_skin_inflammation2.66100166
19MP0000427_abnormal_hair_cycle2.20001941
20MP0009780_abnormal_chondrocyte_physiolo2.03751343
21MP0005451_abnormal_body_composition2.03330658
22MP0001346_abnormal_lacrimal_gland2.02632896
23MP0003566_abnormal_cell_adhesion1.90383147
24MP0000467_abnormal_esophagus_morphology1.85808033
25MP0000566_synostosis1.83101108
26MP0002009_preneoplasia1.75807359
27MP0003705_abnormal_hypodermis_morpholog1.69900313
28MP0000762_abnormal_tongue_morphology1.60002580
29MP0009931_abnormal_skin_appearance1.56159475
30MP0001191_abnormal_skin_condition1.53622566
31MP0000367_abnormal_coat/_hair1.50278688
32MP0003950_abnormal_plasma_membrane1.50258231
33MP0001243_abnormal_dermal_layer1.44216416
34MP0005408_hypopigmentation1.38647432
35MP0004043_abnormal_pH_regulation1.36709551
36MP0003878_abnormal_ear_physiology1.35679250
37MP0005377_hearing/vestibular/ear_phenot1.35679250
38MP0005083_abnormal_biliary_tract1.22055709
39MP0008875_abnormal_xenobiotic_pharmacok1.21387548
40MP0001851_eye_inflammation1.20768718
41MP0004782_abnormal_surfactant_physiolog1.18479353
42MP0004185_abnormal_adipocyte_glucose1.17532949
43MP0003191_abnormal_cellular_cholesterol1.07473692
44MP0008004_abnormal_stomach_pH1.04046935
45MP0000627_abnormal_mammary_gland1.00848549
46MP0002006_tumorigenesis0.96943359
47MP0002653_abnormal_ependyma_morphology0.96504588
48MP0002166_altered_tumor_susceptibility0.94895792
49MP0001188_hyperpigmentation0.93992453
50MP0002148_abnormal_hypersensitivity_rea0.93827808
51MP0003436_decreased_susceptibility_to0.93370196
52MP0000516_abnormal_urinary_system0.93328074
53MP0005367_renal/urinary_system_phenotyp0.93328074
54MP0009379_abnormal_foot_pigmentation0.92179293
55MP0004264_abnormal_extraembryonic_tissu0.86662447
56MP0004019_abnormal_vitamin_homeostasis0.86239434
57MP0010352_gastrointestinal_tract_polyps0.84355251
58MP0005076_abnormal_cell_differentiation0.82621464
59MP0002277_abnormal_respiratory_mucosa0.80913224
60MP0001340_abnormal_eyelid_morphology0.79266957
61MP0004885_abnormal_endolymph0.77720047
62MP0010030_abnormal_orbit_morphology0.76259182
63MP0001666_abnormal_nutrient_absorption0.74302376
64MP0001756_abnormal_urination0.72717088
65MP0000465_gastrointestinal_hemorrhage0.72192497
66MP0002876_abnormal_thyroid_physiology0.71491995
67MP0002168_other_aberrant_phenotype0.70581189
68MP0005075_abnormal_melanosome_morpholog0.70044561
69MP0005023_abnormal_wound_healing0.69501949
70MP0003011_delayed_dark_adaptation0.67988023
71MP0002234_abnormal_pharynx_morphology0.65159985
72MP0000538_abnormal_urinary_bladder0.64203985
73MP0010386_abnormal_urinary_bladder0.62460027
74MP0003195_calcinosis0.61595702
75MP0000003_abnormal_adipose_tissue0.61502343
76MP0003638_abnormal_response/metabolism_0.60267446
77MP0001835_abnormal_antigen_presentation0.59195200
78MP0003300_gastrointestinal_ulcer0.58760491
79MP0009053_abnormal_anal_canal0.58181067
80MP0002909_abnormal_adrenal_gland0.58177544
81MP0002095_abnormal_skin_pigmentation0.57524587
82MP0001849_ear_inflammation0.57285670
83MP0001881_abnormal_mammary_gland0.57091661
84MP0001765_abnormal_ion_homeostasis0.56604709
85MP0004858_abnormal_nervous_system0.56427529
86MP0000537_abnormal_urethra_morphology0.55614838
87MP0003315_abnormal_perineum_morphology0.55428975
88MP0006054_spinal_hemorrhage0.54077109
89MP0005025_abnormal_response_to0.52158206
90MP0003136_yellow_coat_color0.51309842
91MP0002877_abnormal_melanocyte_morpholog0.49094112
92MP0009785_altered_susceptibility_to0.48792916
93MP0008995_early_reproductive_senescence0.48355916
94MP0001533_abnormal_skeleton_physiology0.47746812
95MP0003448_altered_tumor_morphology0.47104374
96MP0005647_abnormal_sex_gland0.46329211
97MP0002282_abnormal_trachea_morphology0.45895835
98MP0001784_abnormal_fluid_regulation0.45753019
99MP0005248_abnormal_Harderian_gland0.45258552
100MP0002111_abnormal_tail_morphology0.45136056
101MP0005395_other_phenotype0.43646718
102MP0002090_abnormal_vision0.42954084
103MP0001984_abnormal_olfaction0.42905814
104MP0004272_abnormal_basement_membrane0.42896505
105MP0010155_abnormal_intestine_physiology0.42228123
106MP0005000_abnormal_immune_tolerance0.42220074
107MP0000685_abnormal_immune_system0.42095010
108MP0009384_cardiac_valve_regurgitation0.41903955
109MP0001790_abnormal_immune_system0.41539284
110MP0005387_immune_system_phenotype0.41539284
111MP0003786_premature_aging0.41506871
112MP0002177_abnormal_outer_ear0.40848681
113MP0005365_abnormal_bile_salt0.40826828
114MP0005646_abnormal_pituitary_gland0.40628022
115MP0005375_adipose_tissue_phenotype0.39721893
116MP0003943_abnormal_hepatobiliary_system0.39469411
117MP0005636_abnormal_mineral_homeostasis0.39417084
118MP0008872_abnormal_physiological_respon0.39244490
119MP0001502_abnormal_circadian_rhythm0.38965360
120MP0003045_fibrosis0.38910647
121MP0005390_skeleton_phenotype0.38526849
122MP0000470_abnormal_stomach_morphology0.38256677
123MP0003763_abnormal_thymus_physiology0.37857073
124MP0001873_stomach_inflammation0.37068054
125MP0002249_abnormal_larynx_morphology0.35216163
126MP0005508_abnormal_skeleton_morphology0.35077641
127MP0005409_darkened_coat_color0.34820693
128MP0003303_peritoneal_inflammation0.34644798
129MP0003755_abnormal_palate_morphology0.34581999
130MP0005310_abnormal_salivary_gland0.34533395
131MP0003183_abnormal_peptide_metabolism0.32795056
132MP0003936_abnormal_reproductive_system0.30988703
133MP0002452_abnormal_antigen_presenting0.29295343
134MP0000613_abnormal_salivary_gland0.28413728
135MP0002998_abnormal_bone_remodeling0.28382752

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.79419228
2Hypotrichosis (HP:0001006)7.69843439
3Woolly hair (HP:0002224)6.97252880
4Onycholysis (HP:0001806)6.39673060
5Congenital ichthyosiform erythroderma (HP:0007431)6.30989165
6Plantar hyperkeratosis (HP:0007556)6.30203609
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.25310693
8Right ventricular cardiomyopathy (HP:0011663)6.23598668
9Abnormality of nail color (HP:0100643)6.23436358
10Palmoplantar hyperkeratosis (HP:0000972)5.95620445
11Palmar hyperkeratosis (HP:0010765)5.62983767
12Erythema (HP:0010783)5.34423352
13Fragile nails (HP:0001808)5.32023516
14Parakeratosis (HP:0001036)5.18336680
15Erythroderma (HP:0001019)5.13921162
16Lip pit (HP:0100267)4.98207687
17Pili torti (HP:0003777)4.57978034
18Milia (HP:0001056)4.57625763
19Nail dystrophy (HP:0008404)4.12621861
20Abnormal blistering of the skin (HP:0008066)3.94410184
21Thick nail (HP:0001805)3.92873527
22Natal tooth (HP:0000695)3.86518834
23Curly hair (HP:0002212)3.45539248
24Oral leukoplakia (HP:0002745)3.42681640
25Corneal erosion (HP:0200020)3.41825096
26Ectropion (HP:0000656)3.41413505
27Advanced eruption of teeth (HP:0006288)3.38365103
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36939329
29Sparse scalp hair (HP:0002209)3.29336999
30Hypohidrosis (HP:0000966)3.23435051
31Chronic bronchitis (HP:0004469)3.23062254
32Conjunctival hamartoma (HP:0100780)3.11948262
33Sparse eyelashes (HP:0000653)3.10199448
34Brittle hair (HP:0002299)3.09482219
35Alopecia of scalp (HP:0002293)3.01590602
36Abnormal hair laboratory examination (HP:0003328)2.93337255
37Pruritus (HP:0000989)2.91259231
38Gangrene (HP:0100758)2.90565880
39Atrophic scars (HP:0001075)2.87687533
40Abnormality of secondary sexual hair (HP:0009888)2.84506365
41Abnormality of the axillary hair (HP:0100134)2.84506365
42Ventricular tachycardia (HP:0004756)2.82143487
43Palmoplantar keratoderma (HP:0000982)2.75970248
44Hypergammaglobulinemia (HP:0010702)2.75041808
45Acanthosis nigricans (HP:0000956)2.74839416
46Popliteal pterygium (HP:0009756)2.73898118
47Amelogenesis imperfecta (HP:0000705)2.72018400
48Abnormality of the dental root (HP:0006486)2.60728149
49Taurodontia (HP:0000679)2.60728149
50Abnormality of permanent molar morphology (HP:0011071)2.60728149
51Concave nail (HP:0001598)2.58907858
52Distal lower limb muscle weakness (HP:0009053)2.58263461
53Abnormality of the gastric mucosa (HP:0004295)2.54858152
54Hyporeflexia of lower limbs (HP:0002600)2.52787697
55Abnormal respiratory motile cilium physiology (HP:0012261)2.49530895
56Absent eyelashes (HP:0000561)2.49232461
57Eczematoid dermatitis (HP:0000976)2.47784354
58Rhinitis (HP:0012384)2.47455458
59Furrowed tongue (HP:0000221)2.44513730
60Abnormality of the dental pulp (HP:0006479)2.42972560
61Abnormality of molar morphology (HP:0011070)2.42963109
62Abnormality of molar (HP:0011077)2.42963109
63Aplasia cutis congenita (HP:0001057)2.42175158
64Absent/shortened dynein arms (HP:0200106)2.39152738
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.39152738
66Abnormal respiratory motile cilium morphology (HP:0005938)2.35340596
67Abnormal respiratory epithelium morphology (HP:0012253)2.35340596
68Abnormality of the nasal septum (HP:0000419)2.33159169
69Tubulointerstitial nephritis (HP:0001970)2.31836578
70Blepharitis (HP:0000498)2.28815409
71Abnormal ciliary motility (HP:0012262)2.21474728
72Pustule (HP:0200039)2.20734773
73Ridged nail (HP:0001807)2.19890930
74Hyperactive renin-angiotensin system (HP:0000841)2.18482042
75Duplicated collecting system (HP:0000081)2.17559370
76Sparse lateral eyebrow (HP:0005338)2.15873089
77Septate vagina (HP:0001153)2.15864297
78Malnutrition (HP:0004395)2.13964275
79Oligodontia (HP:0000677)2.13195951
80Depressed nasal tip (HP:0000437)2.09321419
81Labial hypoplasia (HP:0000066)2.07972263
82Tubular atrophy (HP:0000092)2.07618404
83Renal salt wasting (HP:0000127)2.07256186
84Interstitial pulmonary disease (HP:0006530)2.06514749
85Hypoplastic labia majora (HP:0000059)2.06136648
86Absent hair (HP:0002298)2.04976694
87Congenital, generalized hypertrichosis (HP:0004540)2.04403921
88Dehydration (HP:0001944)2.03943995
89Ventricular fibrillation (HP:0001663)2.01846122
90Corneal dystrophy (HP:0001131)2.00338784
91Villous atrophy (HP:0011473)2.00310602
92Abnormality of small intestinal villus morphology (HP:0011472)2.00310602
93Ulnar claw (HP:0001178)2.00117827
94Dry hair (HP:0011359)1.99430329
95Dry skin (HP:0000958)1.97432612
96Abnormality of the salivary glands (HP:0010286)1.96981541
97Hypoplasia of dental enamel (HP:0006297)1.95565491
98Bronchiectasis (HP:0002110)1.93952134
99Anhidrosis (HP:0000970)1.92183450
100Abnormality of the renal collecting system (HP:0004742)1.91936060
101Skin ulcer (HP:0200042)1.90849896
102Selective tooth agenesis (HP:0001592)1.87651790
103Urticaria (HP:0001025)1.85173132
104Hypoplastic female external genitalia (HP:0012815)1.84584872
105Abnormality of the labia majora (HP:0012881)1.83622967
106Fatigable weakness (HP:0003473)1.83431246
107Abnormality of the neuromuscular junction (HP:0003398)1.83431246
108Follicular hyperkeratosis (HP:0007502)1.80158212
109Abnormality of hair growth rate (HP:0011363)1.78699533
110Slow-growing hair (HP:0002217)1.78699533
111Chronic otitis media (HP:0000389)1.76631900
112Hamartoma of the eye (HP:0010568)1.75743820
113Severe Myopia (HP:0011003)1.72866993
114Pterygium (HP:0001059)1.72669541
115Cone-rod dystrophy (HP:0000548)1.70334059
116Premature loss of primary teeth (HP:0006323)1.69957053
117Nasolacrimal duct obstruction (HP:0000579)1.66565915
118Hypodontia (HP:0000668)1.61454530
119Anonychia (HP:0001798)1.59865903
120Down-sloping shoulders (HP:0200021)1.58240282
121Abnormality of the labia (HP:0000058)1.54775706
122Fragile skin (HP:0001030)1.54098671
123Hyperhidrosis (HP:0000975)1.53373720
124Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.53200495
125Lack of skin elasticity (HP:0100679)1.51708001
126Skin pits (HP:0100276)1.48976619
127Recurrent bacterial skin infections (HP:0005406)1.48152529
128Laryngomalacia (HP:0001601)1.46564826
129Areflexia of lower limbs (HP:0002522)1.45252220
130Absent eyebrow (HP:0002223)1.44578466
131Abnormality of the distal phalanges of the toes (HP:0010182)1.44115990
132Nasal polyposis (HP:0100582)1.42525345
133Sepsis (HP:0100806)1.40720143
134Aplasia involving bones of the upper limbs (HP:0009823)1.38846712
135Aplasia of the phalanges of the hand (HP:0009802)1.38846712
136Aplasia involving bones of the extremities (HP:0009825)1.38846712
137Prostate neoplasm (HP:0100787)1.38339552
138Abnormal hemoglobin (HP:0011902)1.36571220

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.95445740
2MAPKAPK34.70463811
3FER3.71714980
4MST1R3.37519690
5MAP3K33.32661615
6EPHA22.98887543
7LATS12.49264117
8BLK2.41583966
9BRSK22.37006946
10RPS6KB22.27640209
11MAP3K22.23992096
12EPHB22.18622952
13EPHA32.12183849
14ERN12.03767748
15TRPM72.01277963
16PIM21.92062321
17MAP3K141.80618264
18EPHB11.66524141
19MAP3K121.54363116
20STK241.54071105
21TYK21.50740384
22TGFBR21.50186267
23WEE11.50072973
24RIPK41.49023225
25BCR1.42967910
26NME11.39117767
27AKT31.38023223
28PIK3CG1.36527502
29PTK61.35023621
30TRIM281.29610887
31PKN21.29587054
32FGFR31.28706815
33FGFR41.26653457
34EEF2K1.26178693
35SIK31.26113981
36LRRK21.19672367
37MAP3K91.18680247
38GRK11.15361981
39STK391.14834500
40ERBB31.13182527
41TGFBR11.12204665
42IKBKE1.11400101
43TBK11.09025776
44DYRK1B1.06678008
45IRAK31.04876367
46STK101.03365769
47FGFR20.99208751
48CDK60.98695161
49TESK10.98079669
50PBK0.93254780
51MAP2K60.90918701
52MAPKAPK50.90720631
53IKBKB0.90719851
54STK380.88739879
55MAP3K10.87877347
56MATK0.87698094
57FGFR10.87505500
58TNK20.86724303
59SIK10.86607391
60FRK0.84685404
61EIF2AK30.83976154
62RIPK10.82773702
63EIF2AK10.82337456
64MET0.81220615
65MAPKAPK20.81044483
66TAOK10.79713542
67MAP2K30.76654869
68JAK10.72240887
69HCK0.69106632
70MAP3K110.68729819
71BMPR1B0.67254045
72RPS6KA40.65504553
73STK30.64448320
74ITK0.63368276
75CDK30.63010776
76MUSK0.62767046
77NEK90.62580385
78OXSR10.62159063
79MAPK150.61512850
80YES10.61116265
81CHUK0.59381769
82GRK70.58462821
83TTN0.58049617
84PRKAA20.55127271
85PAK30.54894593
86NUAK10.54378936
87NEK60.54093306
88PRKCE0.53357892
89PTK20.48814554
90ILK0.47399087
91PDGFRB0.45609987
92NME20.45262046
93RPS6KA10.44730123
94JAK20.43961923
95MAP3K60.42833381
96MAP3K50.42296192
97IRAK10.41235874
98INSRR0.41214301
99BTK0.41025956
100ERBB20.40130247
101BMX0.39994892
102DMPK0.39968064
103HIPK20.39805275
104MAP3K70.39718227
105JAK30.39030167
106RPS6KA20.38875387
107LMTK20.38011020
108STK38L0.36282413
109CASK0.36018644
110SYK0.35959146
111MAP2K10.35642098
112TRIB30.35089043
113PRKD10.34602174
114ROCK10.34389621
115PIK3CA0.33793746
116LATS20.33663019
117ADRBK20.32887950
118MTOR0.32526883
119TLK10.31975228
120EGFR0.31245691
121NLK0.31193205
122BRSK10.30027207
123ABL10.29770943
124SRC0.27303553
125CSNK1E0.26791315
126PRKCI0.25913943
127ZAP700.25725255
128GSK3A0.25666150
129EIF2AK20.25619667
130CAMK1D0.25466821
131PAK40.25325080
132IGF1R0.24702158
133CSK0.24606070
134ERBB40.24105354
135SGK2230.24087743
136SGK4940.24087743
137ABL20.23932922
138ADRBK10.23788350
139RPS6KC10.23085743
140CSNK1G10.21935668
141CSNK1A10.21904503
142PRKD20.18840839
143SGK30.18214162
144TSSK60.16009289

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006002.88956678
2Circadian rhythm_Homo sapiens_hsa047102.76248809
3Ovarian steroidogenesis_Homo sapiens_hsa049132.17585997
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.11108274
5Steroid hormone biosynthesis_Homo sapiens_hsa001401.99019748
6Linoleic acid metabolism_Homo sapiens_hsa005911.95082278
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92650476
8Arachidonic acid metabolism_Homo sapiens_hsa005901.90699316
9Chemical carcinogenesis_Homo sapiens_hsa052041.90164702
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84465126
11Staphylococcus aureus infection_Homo sapiens_hsa051501.75048846
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.69331352
13Pertussis_Homo sapiens_hsa051331.62775481
14Adherens junction_Homo sapiens_hsa045201.51656961
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47347744
16Tyrosine metabolism_Homo sapiens_hsa003501.47204066
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.44491926
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43913468
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41647588
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.38495394
21Ether lipid metabolism_Homo sapiens_hsa005651.38042421
22Toxoplasmosis_Homo sapiens_hsa051451.37173854
23Collecting duct acid secretion_Homo sapiens_hsa049661.32458697
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.31993365
25Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28479538
26Phenylalanine metabolism_Homo sapiens_hsa003601.26540686
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25566065
28Osteoclast differentiation_Homo sapiens_hsa043801.25014358
29Leishmaniasis_Homo sapiens_hsa051401.24319366
30VEGF signaling pathway_Homo sapiens_hsa043701.24207836
31Glutathione metabolism_Homo sapiens_hsa004801.22738383
32Sulfur metabolism_Homo sapiens_hsa009201.20675500
33Histidine metabolism_Homo sapiens_hsa003401.19591865
34Tight junction_Homo sapiens_hsa045301.19440164
35Sphingolipid signaling pathway_Homo sapiens_hsa040711.19429615
36ECM-receptor interaction_Homo sapiens_hsa045121.18895430
37Basal cell carcinoma_Homo sapiens_hsa052171.17002409
38Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16890872
39Lysosome_Homo sapiens_hsa041421.13910840
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13792976
41Tuberculosis_Homo sapiens_hsa051521.13340321
42Hepatitis C_Homo sapiens_hsa051601.13215847
43Amoebiasis_Homo sapiens_hsa051461.11878990
44Fatty acid elongation_Homo sapiens_hsa000621.11009510
45Proteoglycans in cancer_Homo sapiens_hsa052051.05969668
46Steroid biosynthesis_Homo sapiens_hsa001001.05884683
47Glycerophospholipid metabolism_Homo sapiens_hsa005641.05116172
48NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05058840
49Graft-versus-host disease_Homo sapiens_hsa053321.04379523
50TNF signaling pathway_Homo sapiens_hsa046681.04152417
51Hippo signaling pathway_Homo sapiens_hsa043901.02481379
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02313930
53Rheumatoid arthritis_Homo sapiens_hsa053231.01162795
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00526566
55Axon guidance_Homo sapiens_hsa043600.98997953
56beta-Alanine metabolism_Homo sapiens_hsa004100.98901211
57Jak-STAT signaling pathway_Homo sapiens_hsa046300.96528900
58Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96068346
59Mineral absorption_Homo sapiens_hsa049780.95501541
60Bladder cancer_Homo sapiens_hsa052190.95377767
61Other glycan degradation_Homo sapiens_hsa005110.92724556
62Thyroid cancer_Homo sapiens_hsa052160.92721699
63Salmonella infection_Homo sapiens_hsa051320.91492513
64Influenza A_Homo sapiens_hsa051640.90267198
65Ribosome_Homo sapiens_hsa030100.89316253
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88058778
67Vitamin digestion and absorption_Homo sapiens_hsa049770.87953293
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87699144
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87038481
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84594710
71Acute myeloid leukemia_Homo sapiens_hsa052210.84577363
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.84250722
73p53 signaling pathway_Homo sapiens_hsa041150.83246201
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82517229
75Small cell lung cancer_Homo sapiens_hsa052220.82470822
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82353443
77Inositol phosphate metabolism_Homo sapiens_hsa005620.82324400
78Platelet activation_Homo sapiens_hsa046110.81336593
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.81164568
80GnRH signaling pathway_Homo sapiens_hsa049120.80927441
81Legionellosis_Homo sapiens_hsa051340.80741699
82Phagosome_Homo sapiens_hsa041450.80642800
83Notch signaling pathway_Homo sapiens_hsa043300.79372279
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.78460578
85Tryptophan metabolism_Homo sapiens_hsa003800.78086710
86Melanogenesis_Homo sapiens_hsa049160.78009811
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77802719
88Melanoma_Homo sapiens_hsa052180.77130520
89Apoptosis_Homo sapiens_hsa042100.76211020
90Ras signaling pathway_Homo sapiens_hsa040140.75607280
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74611818
92Malaria_Homo sapiens_hsa051440.74502839
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74472972
94Nitrogen metabolism_Homo sapiens_hsa009100.74164386
95Caffeine metabolism_Homo sapiens_hsa002320.74106079
96Choline metabolism in cancer_Homo sapiens_hsa052310.73735660
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73713363
98ErbB signaling pathway_Homo sapiens_hsa040120.73520866
99Pancreatic secretion_Homo sapiens_hsa049720.72556048
100Antigen processing and presentation_Homo sapiens_hsa046120.71491061
101Vibrio cholerae infection_Homo sapiens_hsa051100.70959588
102Measles_Homo sapiens_hsa051620.70634984
103Rap1 signaling pathway_Homo sapiens_hsa040150.69863086
104Retinol metabolism_Homo sapiens_hsa008300.69734163
105Renin secretion_Homo sapiens_hsa049240.69394435
106Hedgehog signaling pathway_Homo sapiens_hsa043400.69195132
107MicroRNAs in cancer_Homo sapiens_hsa052060.67100607
108Hematopoietic cell lineage_Homo sapiens_hsa046400.66098521
109Endocytosis_Homo sapiens_hsa041440.64872211
110Fructose and mannose metabolism_Homo sapiens_hsa000510.64058464
111Prostate cancer_Homo sapiens_hsa052150.63864168
112Phototransduction_Homo sapiens_hsa047440.63068417
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62881734
114Protein export_Homo sapiens_hsa030600.62504220
115Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62441642
116TGF-beta signaling pathway_Homo sapiens_hsa043500.62187319
117Salivary secretion_Homo sapiens_hsa049700.61731590
118B cell receptor signaling pathway_Homo sapiens_hsa046620.61431982
119Dorso-ventral axis formation_Homo sapiens_hsa043200.60866143
120ABC transporters_Homo sapiens_hsa020100.60523422
121Prolactin signaling pathway_Homo sapiens_hsa049170.60436485
122Selenocompound metabolism_Homo sapiens_hsa004500.59883123
123Endometrial cancer_Homo sapiens_hsa052130.57953488
124Pancreatic cancer_Homo sapiens_hsa052120.57751146
125African trypanosomiasis_Homo sapiens_hsa051430.56039050
126Gastric acid secretion_Homo sapiens_hsa049710.55566946
127T cell receptor signaling pathway_Homo sapiens_hsa046600.55300812
128PPAR signaling pathway_Homo sapiens_hsa033200.54688094
129Insulin resistance_Homo sapiens_hsa049310.54562971
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54201340
131Arginine and proline metabolism_Homo sapiens_hsa003300.53339266
132Chemokine signaling pathway_Homo sapiens_hsa040620.52485930
133Pathways in cancer_Homo sapiens_hsa052000.52387010
134Regulation of autophagy_Homo sapiens_hsa041400.44539595
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44386441
136Fat digestion and absorption_Homo sapiens_hsa049750.44272177
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.44232550
138Fatty acid biosynthesis_Homo sapiens_hsa000610.42590236
139Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42295859
140Peroxisome_Homo sapiens_hsa041460.40450981
141N-Glycan biosynthesis_Homo sapiens_hsa005100.35887859
142Protein digestion and absorption_Homo sapiens_hsa049740.31450889
143Metabolic pathways_Homo sapiens_hsa011000.30569191
144Estrogen signaling pathway_Homo sapiens_hsa049150.30490650
145AMPK signaling pathway_Homo sapiens_hsa041520.30018032
146Glycerolipid metabolism_Homo sapiens_hsa005610.29974763

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