NEDD4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55219521
2locomotory exploration behavior (GO:0035641)5.01447906
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01174690
4vocalization behavior (GO:0071625)4.99436193
5synaptic vesicle maturation (GO:0016188)4.78396288
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75563551
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72388712
8synaptic vesicle exocytosis (GO:0016079)4.61776991
9regulation of glutamate receptor signaling pathway (GO:1900449)4.59080485
10glutamate secretion (GO:0014047)4.55422482
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.45563400
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.40859602
13regulation of synaptic vesicle exocytosis (GO:2000300)4.23544415
14regulation of synapse structural plasticity (GO:0051823)4.06414193
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.04980641
16neurotransmitter-gated ion channel clustering (GO:0072578)4.03700584
17protein localization to synapse (GO:0035418)3.98487812
18regulation of synaptic vesicle transport (GO:1902803)3.95972306
19exploration behavior (GO:0035640)3.95530852
20regulation of neuronal synaptic plasticity (GO:0048168)3.95243655
21neurotransmitter secretion (GO:0007269)3.88336767
22neuron cell-cell adhesion (GO:0007158)3.87933892
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.83811789
24glutamate receptor signaling pathway (GO:0007215)3.83703074
25synaptic transmission, glutamatergic (GO:0035249)3.83297721
26layer formation in cerebral cortex (GO:0021819)3.78098012
27behavioral response to nicotine (GO:0035095)3.74596708
28cerebral cortex radially oriented cell migration (GO:0021799)3.66028947
29neuron-neuron synaptic transmission (GO:0007270)3.62781251
30regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59829955
31membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57414928
32positive regulation of synapse maturation (GO:0090129)3.51130753
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50217735
34neuronal action potential propagation (GO:0019227)3.49821186
35cell migration in hindbrain (GO:0021535)3.49351564
36proline transport (GO:0015824)3.49345048
37gamma-aminobutyric acid transport (GO:0015812)3.48069400
38regulation of dendritic spine morphogenesis (GO:0061001)3.44252474
39presynaptic membrane assembly (GO:0097105)3.41573298
40regulation of postsynaptic membrane potential (GO:0060078)3.40748130
41neuron recognition (GO:0008038)3.36559908
42presynaptic membrane organization (GO:0097090)3.35863595
43prepulse inhibition (GO:0060134)3.33247212
44positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33051708
45dendritic spine morphogenesis (GO:0060997)3.31680963
46long-term memory (GO:0007616)3.31155531
47dendrite morphogenesis (GO:0048813)3.29949512
48negative regulation of dendrite development (GO:2000171)3.28769351
49negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.28118283
50cellular potassium ion homeostasis (GO:0030007)3.28034820
51regulation of synapse maturation (GO:0090128)3.27175928
52positive regulation of membrane potential (GO:0045838)3.25953752
53regulation of synaptic plasticity (GO:0048167)3.24853770
54behavioral defense response (GO:0002209)3.23918767
55behavioral fear response (GO:0001662)3.23918767
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.23064220
57negative regulation of dendrite morphogenesis (GO:0050774)3.21582766
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.21509136
59neuromuscular process controlling balance (GO:0050885)3.18670195
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17700708
61positive regulation of dendritic spine morphogenesis (GO:0061003)3.16767017
62axonal fasciculation (GO:0007413)3.14320033
63membrane depolarization during action potential (GO:0086010)3.13745834
64membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.13025440
65activation of protein kinase A activity (GO:0034199)3.12560879
66innervation (GO:0060384)3.08969641
67nucleobase catabolic process (GO:0046113)3.08690290
68sodium ion export (GO:0071436)3.08524624
69cell communication by electrical coupling (GO:0010644)3.07971530
70synapse assembly (GO:0007416)3.06983627
71adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.04320464
72neurotransmitter transport (GO:0006836)3.04067647
73dopamine receptor signaling pathway (GO:0007212)3.01365810
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01030270
75membrane hyperpolarization (GO:0060081)3.00803113
76substrate-independent telencephalic tangential migration (GO:0021826)2.99871528
77substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.99871528
78membrane depolarization (GO:0051899)2.98083810
79cerebellar Purkinje cell differentiation (GO:0021702)2.97619957
80cell proliferation in forebrain (GO:0021846)2.97109317
81regulation of vesicle fusion (GO:0031338)2.96581404
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.95500251
83positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94915175
84response to histamine (GO:0034776)2.93310024
85membrane repolarization during action potential (GO:0086011)2.92021251
86fear response (GO:0042596)2.91565633
87synaptic vesicle endocytosis (GO:0048488)2.91242920
88regulation of neurotransmitter secretion (GO:0046928)2.91194325
89limb bud formation (GO:0060174)2.90708501
90regulation of neurotransmitter levels (GO:0001505)2.88866795
91long-term synaptic potentiation (GO:0060291)2.87041740
92regulation of dendritic spine development (GO:0060998)2.86147549
93auditory behavior (GO:0031223)2.83630751
94striatum development (GO:0021756)2.82564146
95cell communication involved in cardiac conduction (GO:0086065)2.82511360
96positive regulation of fibroblast migration (GO:0010763)2.81868073
97positive regulation of neurotransmitter secretion (GO:0001956)2.80576783
98positive regulation of neurotransmitter transport (GO:0051590)2.79117080
99transmission of nerve impulse (GO:0019226)2.78727067
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.76300375
101regulation of neurotransmitter transport (GO:0051588)2.76218505
102neuromuscular process (GO:0050905)2.76029682
103spinal cord development (GO:0021510)2.75948973
104vesicle transport along microtubule (GO:0047496)2.75788506
105pyrimidine nucleobase catabolic process (GO:0006208)2.75406678
106behavioral response to cocaine (GO:0048148)2.74598145
107cerebellar granule cell differentiation (GO:0021707)2.73244326
108postsynaptic membrane organization (GO:0001941)2.71379015
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.71034714
110learning (GO:0007612)2.68221693
111neuronal action potential (GO:0019228)2.67383757
112artery development (GO:0060840)2.66957297
113central nervous system projection neuron axonogenesis (GO:0021952)2.66532500
114response to auditory stimulus (GO:0010996)2.66022100
115establishment of nucleus localization (GO:0040023)2.64742328
116regulation of female receptivity (GO:0045924)2.64484474
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.62486069
118retinal ganglion cell axon guidance (GO:0031290)2.57542672
119neurofilament cytoskeleton organization (GO:0060052)2.55689050
120positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.55270875
121regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53470392
122cerebral cortex cell migration (GO:0021795)2.52202150
123negative regulation of astrocyte differentiation (GO:0048712)2.51855273
124axon ensheathment in central nervous system (GO:0032291)2.51142726
125central nervous system myelination (GO:0022010)2.51142726
126membrane repolarization (GO:0086009)2.49383112
127serotonin metabolic process (GO:0042428)2.43777813
128positive regulation of action potential (GO:0045760)2.42566053
129axon extension (GO:0048675)2.40521370
130regulation of hippo signaling (GO:0035330)2.39672762
131synapse organization (GO:0050808)2.37049080
132positive regulation of synapse assembly (GO:0051965)2.36568805
133primary amino compound metabolic process (GO:1901160)2.35277449
134multicellular organismal signaling (GO:0035637)2.35264926
135regulation of non-canonical Wnt signaling pathway (GO:2000050)2.32950670
136embryonic retina morphogenesis in camera-type eye (GO:0060059)2.30029215
137forebrain neuron differentiation (GO:0021879)2.28251096
138establishment of mitochondrion localization (GO:0051654)2.26912186
139adult walking behavior (GO:0007628)2.26074435
140positive regulation of sodium ion transmembrane transport (GO:1902307)2.24459964
141positive regulation of cardiac muscle cell differentiation (GO:2000727)2.23296891
142neuromuscular synaptic transmission (GO:0007274)2.22933884
143somite development (GO:0061053)2.22596336
144positive regulation of dendritic spine development (GO:0060999)2.22248372
145regulation of heart rate by cardiac conduction (GO:0086091)2.21421666
146parturition (GO:0007567)2.20331622
147camera-type eye morphogenesis (GO:0048593)2.19208848
148mechanosensory behavior (GO:0007638)2.19109963
149cellular anion homeostasis (GO:0030002)2.18424466
150peristalsis (GO:0030432)2.17841465
151C4-dicarboxylate transport (GO:0015740)2.17386289
152regulation of synapse assembly (GO:0051963)2.17339593
153dendrite development (GO:0016358)2.16401239
154forebrain cell migration (GO:0021885)2.14726208
155regulation of translation, ncRNA-mediated (GO:0045974)2.14683474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42689540
2GBX2_23144817_ChIP-Seq_PC3_Human3.34189499
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77136228
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71742448
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62593254
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46304219
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46304219
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.43862736
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37620083
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.36708533
11DROSHA_22980978_ChIP-Seq_HELA_Human2.34496397
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30485156
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28911286
14SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.26517473
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.20088920
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.18432343
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17124363
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.13643127
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.99623383
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97727576
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.95869760
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.94896595
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91756115
24* REST_18959480_ChIP-ChIP_MESCs_Mouse1.91320967
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81614447
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78605440
27AR_21572438_ChIP-Seq_LNCaP_Human1.76962380
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73898849
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73491841
30* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69025094
31VDR_22108803_ChIP-Seq_LS180_Human1.68874761
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67405635
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60085808
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.56504364
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54813821
36TAF15_26573619_Chip-Seq_HEK293_Human1.52916125
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48040623
38* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47124000
39IGF1R_20145208_ChIP-Seq_DFB_Human1.45172672
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45151922
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43978484
42ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42077338
43* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40001278
44* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36426424
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35208552
46* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33029249
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32624317
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.32275679
49ZNF274_21170338_ChIP-Seq_K562_Hela1.31966424
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31257029
51AHR_22903824_ChIP-Seq_MCF-7_Human1.31036710
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29085697
53TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28601166
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.28118170
55AR_25329375_ChIP-Seq_VCAP_Human1.26791585
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25064532
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.24397928
58* P300_19829295_ChIP-Seq_ESCs_Human1.24032395
59* AR_19668381_ChIP-Seq_PC3_Human1.23486533
60* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23019022
61* STAT3_23295773_ChIP-Seq_U87_Human1.22864440
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21182990
63CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21130098
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.19454804
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18780362
66* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17739046
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.17224054
68* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17207135
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.16778182
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15243798
71FUS_26573619_Chip-Seq_HEK293_Human1.14742433
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14118159
73KDM2B_26808549_Chip-Seq_K562_Human1.14043640
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12914875
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.12556944
76* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12047095
77* SMAD3_21741376_ChIP-Seq_HESCs_Human1.11964415
78DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11354498
79* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10439332
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.09679640
81* SMAD4_21741376_ChIP-Seq_HESCs_Human1.09324917
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08502747
83* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06865567
84KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06856101
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06702203
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05182148
87CBP_20019798_ChIP-Seq_JUKART_Human1.04006483
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04006483
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.03271398
90EWS_26573619_Chip-Seq_HEK293_Human1.03076761
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03040706
92TCF4_23295773_ChIP-Seq_U87_Human1.02033378
93RXR_22108803_ChIP-Seq_LS180_Human1.01947385
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01555057
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00855486
96TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00819749
97GATA1_26923725_Chip-Seq_HPCs_Mouse1.00344505
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00083814
99* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99524374
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99080713
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98296738
102CBX2_27304074_Chip-Seq_ESCs_Mouse0.97671564
103* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97594710
104* TP53_16413492_ChIP-PET_HCT116_Human0.97000671
105ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96997841
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96680765
107BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95696047
108BCAT_22108803_ChIP-Seq_LS180_Human0.95630619
109PRDM14_20953172_ChIP-Seq_ESCs_Human0.94879100
110* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94577953
111RUNX2_22187159_ChIP-Seq_PCA_Human0.93134106
112* EP300_21415370_ChIP-Seq_HL-1_Mouse0.92801350
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.92702207
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92592285
115TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92592285
116RNF2_27304074_Chip-Seq_NSC_Mouse0.90370327
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90259808
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90218645
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90094840
120TP53_18474530_ChIP-ChIP_U2OS_Human0.89948110
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87218577
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.86935041
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.86872960

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.42883121
2MP0003880_abnormal_central_pattern4.28106475
3MP0004270_analgesia4.07628937
4MP0003635_abnormal_synaptic_transmissio3.86524773
5MP0002822_catalepsy3.38213318
6MP0001968_abnormal_touch/_nociception3.37649452
7MP0002063_abnormal_learning/memory/cond3.22925392
8MP0009745_abnormal_behavioral_response3.12919108
9MP0002735_abnormal_chemical_nociception3.00173661
10MP0002064_seizures2.78024400
11MP0002734_abnormal_mechanical_nocicepti2.73776584
12MP0006292_abnormal_olfactory_placode2.72870119
13MP0002736_abnormal_nociception_after2.70215204
14MP0009046_muscle_twitch2.69340453
15MP0000566_synostosis2.66106248
16MP0002572_abnormal_emotion/affect_behav2.61991656
17MP0005423_abnormal_somatic_nervous2.43010766
18MP0002733_abnormal_thermal_nociception2.28368687
19MP0002272_abnormal_nervous_system2.25332049
20MP0001486_abnormal_startle_reflex2.24533477
21MP0004858_abnormal_nervous_system2.12343520
22MP0001970_abnormal_pain_threshold2.04204954
23MP0001440_abnormal_grooming_behavior2.00179315
24MP0006276_abnormal_autonomic_nervous1.97516736
25MP0002184_abnormal_innervation1.90428540
26MP0001501_abnormal_sleep_pattern1.89802963
27MP0000778_abnormal_nervous_system1.86111006
28MP0002067_abnormal_sensory_capabilities1.85669400
29MP0000569_abnormal_digit_pigmentation1.85611433
30MP0002909_abnormal_adrenal_gland1.83147674
31MP0005646_abnormal_pituitary_gland1.75825738
32MP0004811_abnormal_neuron_physiology1.71552542
33MP0003329_amyloid_beta_deposits1.71284967
34MP0005386_behavior/neurological_phenoty1.67494519
35MP0004924_abnormal_behavior1.67494519
36MP0003890_abnormal_embryonic-extraembry1.65091187
37MP0001984_abnormal_olfaction1.64282281
38MP0009780_abnormal_chondrocyte_physiolo1.64161003
39MP0003123_paternal_imprinting1.62774016
40MP0002557_abnormal_social/conspecific_i1.62081321
41MP0002234_abnormal_pharynx_morphology1.61886368
42MP0004885_abnormal_endolymph1.51570181
43MP0003879_abnormal_hair_cell1.50269896
44MP0000537_abnormal_urethra_morphology1.47831771
45MP0010234_abnormal_vibrissa_follicle1.45938175
46MP0003121_genomic_imprinting1.45908045
47MP0000955_abnormal_spinal_cord1.45584780
48MP0008569_lethality_at_weaning1.42451510
49MP0003938_abnormal_ear_development1.34396920
50MP0003315_abnormal_perineum_morphology1.32926390
51MP0004133_heterotaxia1.32065165
52MP0000049_abnormal_middle_ear1.30639153
53MP0002882_abnormal_neuron_morphology1.30076161
54MP0002066_abnormal_motor_capabilities/c1.28705493
55MP0008789_abnormal_olfactory_epithelium1.27009337
56MP0003787_abnormal_imprinting1.25205242
57MP0005409_darkened_coat_color1.24360888
58MP0003942_abnormal_urinary_system1.24079760
59MP0002938_white_spotting1.21646255
60MP0001502_abnormal_circadian_rhythm1.21312321
61MP0009053_abnormal_anal_canal1.18097721
62MP0003937_abnormal_limbs/digits/tail_de1.14682998
63MP0002160_abnormal_reproductive_system1.13993307
64MP0001529_abnormal_vocalization1.12621022
65MP0003119_abnormal_digestive_system1.12405058
66MP0003011_delayed_dark_adaptation1.08325401
67MP0003633_abnormal_nervous_system1.06961628
68MP0008961_abnormal_basal_metabolism1.06795273
69MP0000026_abnormal_inner_ear1.04034403
70MP0001177_atelectasis1.03963988
71MP0003755_abnormal_palate_morphology1.03859934
72* MP0002069_abnormal_eating/drinking_beha1.02104615
73MP0008874_decreased_physiological_sensi1.01939556
74MP0002089_abnormal_postnatal_growth/wei1.01785437
75MP0002152_abnormal_brain_morphology1.00136007
76MP0002102_abnormal_ear_morphology0.98326157
77MP0002653_abnormal_ependyma_morphology0.95977595
78MP0010386_abnormal_urinary_bladder0.93791086
79MP0002233_abnormal_nose_morphology0.90389509
80MP0003631_nervous_system_phenotype0.90328946
81MP0001905_abnormal_dopamine_level0.90292975
82MP0000751_myopathy0.89438783
83MP0005360_urolithiasis0.89044708
84MP0000604_amyloidosis0.88608395
85MP0002837_dystrophic_cardiac_calcinosis0.88434885
86MP0002876_abnormal_thyroid_physiology0.86954871
87MP0005195_abnormal_posterior_eye0.85640774
88MP0008872_abnormal_physiological_respon0.85148444
89MP0003195_calcinosis0.84115552
90MP0002139_abnormal_hepatobiliary_system0.84104144
91MP0005535_abnormal_body_temperature0.83978823
92MP0004510_myositis0.83581069
93MP0008877_abnormal_DNA_methylation0.83226279
94* MP0004085_abnormal_heartbeat0.83071300
95MP0001293_anophthalmia0.80849051
96MP0001299_abnormal_eye_distance/0.80282431
97MP0005085_abnormal_gallbladder_physiolo0.80091421
98MP0002229_neurodegeneration0.79595651
99MP0001666_abnormal_nutrient_absorption0.77652520
100MP0005645_abnormal_hypothalamus_physiol0.76694143
101MP0009250_abnormal_appendicular_skeleto0.76475662
102MP0001188_hyperpigmentation0.74912541
103MP0002116_abnormal_craniofacial_bone0.74381316
104MP0003385_abnormal_body_wall0.74284771
105MP0005551_abnormal_eye_electrophysiolog0.72406336
106MP0004142_abnormal_muscle_tone0.69002321
107MP0005394_taste/olfaction_phenotype0.68847146
108MP0005499_abnormal_olfactory_system0.68847146
109MP0004484_altered_response_of0.68552705
110MP0003075_altered_response_to0.67478811
111MP0001664_abnormal_digestion0.67305143
112MP0004742_abnormal_vestibular_system0.66864646
113MP0004215_abnormal_myocardial_fiber0.66425088
114MP0003646_muscle_fatigue0.64277483
115MP0003122_maternal_imprinting0.63075571
116MP0002752_abnormal_somatic_nervous0.63043031
117MP0000631_abnormal_neuroendocrine_gland0.62263923
118MP0001963_abnormal_hearing_physiology0.61603418
119MP0003632_abnormal_nervous_system0.60746323
120MP0001485_abnormal_pinna_reflex0.58939454
121MP0002090_abnormal_vision0.58874736
122MP0003137_abnormal_impulse_conducting0.58783529
123MP0010329_abnormal_lipoprotein_level0.58189465
124MP0004145_abnormal_muscle_electrophysio0.56770064
125MP0003861_abnormal_nervous_system0.54253347
126MP0004043_abnormal_pH_regulation0.53713052
127MP0005187_abnormal_penis_morphology0.53273607
128MP0003634_abnormal_glial_cell0.52103782
129MP0005365_abnormal_bile_salt0.52093720
130MP0004130_abnormal_muscle_cell0.51789422
131MP0001943_abnormal_respiration0.51592162
132MP0002638_abnormal_pupillary_reflex0.50342308
133MP0005171_absent_coat_pigmentation0.50156592
134MP0000534_abnormal_ureter_morphology0.50034266
135MP0000013_abnormal_adipose_tissue0.49913519

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.05133503
2Myokymia (HP:0002411)6.75122729
3Focal seizures (HP:0007359)5.40896896
4Visual hallucinations (HP:0002367)4.39838229
5Epileptic encephalopathy (HP:0200134)4.04321233
6Progressive cerebellar ataxia (HP:0002073)3.97614952
7Febrile seizures (HP:0002373)3.94728748
8Action tremor (HP:0002345)3.88474836
9Abnormality of the lower motor neuron (HP:0002366)3.42556807
10Atonic seizures (HP:0010819)3.38618226
11Absence seizures (HP:0002121)3.36297897
12Generalized tonic-clonic seizures (HP:0002069)3.27895699
13Hyperventilation (HP:0002883)3.25340086
14Dialeptic seizures (HP:0011146)3.20646634
15Poor eye contact (HP:0000817)3.16536194
16Abnormal social behavior (HP:0012433)3.11726750
17Impaired social interactions (HP:0000735)3.11726750
18Broad-based gait (HP:0002136)3.11657077
19Supranuclear gaze palsy (HP:0000605)3.09872079
20Torticollis (HP:0000473)3.07838037
21Amblyopia (HP:0000646)2.99423807
22Gaze-evoked nystagmus (HP:0000640)2.97532515
23Impaired vibration sensation in the lower limbs (HP:0002166)2.95913111
24Ankle clonus (HP:0011448)2.94905352
25Focal dystonia (HP:0004373)2.93261813
26Urinary bladder sphincter dysfunction (HP:0002839)2.89890478
27Abnormal eating behavior (HP:0100738)2.81348463
28Hepatoblastoma (HP:0002884)2.80513857
29Dysdiadochokinesis (HP:0002075)2.76866454
30Depression (HP:0000716)2.72689094
31Epileptiform EEG discharges (HP:0011182)2.67507355
32Excessive salivation (HP:0003781)2.63342012
33Drooling (HP:0002307)2.63342012
34Scanning speech (HP:0002168)2.61065727
35Genetic anticipation (HP:0003743)2.60036419
36Limb dystonia (HP:0002451)2.58703030
37Urinary urgency (HP:0000012)2.58315742
38Dysmetria (HP:0001310)2.55932692
39Dysmetric saccades (HP:0000641)2.55568373
40Anxiety (HP:0000739)2.55052941
41EEG with generalized epileptiform discharges (HP:0011198)2.54949608
42Abnormality of the nasal septum (HP:0000419)2.54678187
43Craniofacial dystonia (HP:0012179)2.54315822
44Truncal ataxia (HP:0002078)2.49513474
45Ventricular fibrillation (HP:0001663)2.49118983
46Osteomalacia (HP:0002749)2.48894791
47Failure to thrive in infancy (HP:0001531)2.48103753
48Hypsarrhythmia (HP:0002521)2.47906744
49Stereotypic behavior (HP:0000733)2.46488478
50Termporal pattern (HP:0011008)2.45892981
51Insidious onset (HP:0003587)2.45892981
52Impaired smooth pursuit (HP:0007772)2.43928130
53Shawl scrotum (HP:0000049)2.37158541
54Postural instability (HP:0002172)2.34390221
55Blue irides (HP:0000635)2.30804894
56Fetal akinesia sequence (HP:0001989)2.29522142
57Mutism (HP:0002300)2.27643668
58Nephronophthisis (HP:0000090)2.27194414
59Pheochromocytoma (HP:0002666)2.26314711
60True hermaphroditism (HP:0010459)2.21148071
61Status epilepticus (HP:0002133)2.19587330
62Spastic gait (HP:0002064)2.17620684
63Gout (HP:0001997)2.17149667
64Short 4th metacarpal (HP:0010044)2.15683954
65Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.15683954
66Impaired vibratory sensation (HP:0002495)2.13272562
67Chronic hepatic failure (HP:0100626)2.13022594
68Morphological abnormality of the middle ear (HP:0008609)2.12543473
69Abnormality of pain sensation (HP:0010832)2.11912903
70Impaired pain sensation (HP:0007328)2.11912903
71Polyphagia (HP:0002591)2.11520951
72Abnormality of ocular smooth pursuit (HP:0000617)2.10300984
73Bradykinesia (HP:0002067)2.08834381
74Bundle branch block (HP:0011710)2.08539928
75Pancreatic cysts (HP:0001737)2.08165901
76Oligodontia (HP:0000677)2.07728858
77Annular pancreas (HP:0001734)2.06367889
78Decreased circulating renin level (HP:0003351)2.05718505
79Progressive inability to walk (HP:0002505)2.05677457
80Abnormality of the labia minora (HP:0012880)2.04539653
81Pancreatic fibrosis (HP:0100732)2.04512976
82Abnormality of the middle phalanges of the toes (HP:0010183)2.04067528
83Gait imbalance (HP:0002141)2.03561435
84Fibular aplasia (HP:0002990)2.01459900
85Abnormality of the renal medulla (HP:0100957)2.00867014
86Obstructive sleep apnea (HP:0002870)2.00821812
87Incomplete penetrance (HP:0003829)2.00537623
88Lower limb muscle weakness (HP:0007340)2.00339963
89Cystic liver disease (HP:0006706)1.97812373
90Aplasia/Hypoplasia of the sternum (HP:0006714)1.96060106
91Cutaneous finger syndactyly (HP:0010554)1.95710987
92Intention tremor (HP:0002080)1.93119814
93Lower limb asymmetry (HP:0100559)1.92287172
94Cerebral inclusion bodies (HP:0100314)1.91693330
95Pachygyria (HP:0001302)1.90870013
96Short femoral neck (HP:0100864)1.90414869
97Megalencephaly (HP:0001355)1.89293538
98Pointed chin (HP:0000307)1.87624709
99Protruding tongue (HP:0010808)1.87104922
100Tetraplegia (HP:0002445)1.86754233
101Pendular nystagmus (HP:0012043)1.85810996
102Absent speech (HP:0001344)1.84488680
103Abnormality of midbrain morphology (HP:0002418)1.83397468
104Molar tooth sign on MRI (HP:0002419)1.83397468
105Papilledema (HP:0001085)1.82829069
106Lissencephaly (HP:0001339)1.82607580
107Syncope (HP:0001279)1.82562559
108Neurofibrillary tangles (HP:0002185)1.82207650
109Abnormal EKG (HP:0003115)1.82003280
110Abnormality of the proximal phalanges of the hand (HP:0009834)1.81738525
111Optic nerve hypoplasia (HP:0000609)1.81001192
112Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80882293
113Aplasia involving bones of the extremities (HP:0009825)1.79764896
114Aplasia involving bones of the upper limbs (HP:0009823)1.79764896
115Aplasia of the phalanges of the hand (HP:0009802)1.79764896
116Agitation (HP:0000713)1.78736212
117Tented upper lip vermilion (HP:0010804)1.78488669
118Generalized myoclonic seizures (HP:0002123)1.77166954
119Hemiplegia (HP:0002301)1.75107521
120Hemiparesis (HP:0001269)1.75086473
121Genital tract atresia (HP:0001827)1.74994286
122Vaginal atresia (HP:0000148)1.74832331
123Chorioretinal atrophy (HP:0000533)1.74010799
124Gait ataxia (HP:0002066)1.73950569
125Amyotrophic lateral sclerosis (HP:0007354)1.73832805
126Exotropia (HP:0000577)1.73458080
127Medial flaring of the eyebrow (HP:0010747)1.73259294
128Abnormality of the corticospinal tract (HP:0002492)1.73253852
129Prolonged QT interval (HP:0001657)1.73142542
130Thyroid-stimulating hormone excess (HP:0002925)1.72646741
131Hammertoe (HP:0001765)1.71566854
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.71096766
133Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69703688
134Short 1st metacarpal (HP:0010034)1.69703688
135Clonus (HP:0002169)1.68981549
136Metabolic alkalosis (HP:0200114)1.67834763
137Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67413856
138Hypoplasia of the brainstem (HP:0002365)1.67413856
139Neuroendocrine neoplasm (HP:0100634)1.66704555
140Hyperactive renin-angiotensin system (HP:0000841)1.65182405
141Sleep apnea (HP:0010535)1.65125924
142Abnormality of renin-angiotensin system (HP:0000847)1.65057873
143Lower limb amyotrophy (HP:0007210)1.64885679
144Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.64402107
145Abnormality of the aortic arch (HP:0012303)1.64087992
146Abnormal respiratory epithelium morphology (HP:0012253)1.64064611
147Abnormal respiratory motile cilium morphology (HP:0005938)1.64064611
148Abnormality of saccadic eye movements (HP:0000570)1.64020141
149Specific learning disability (HP:0001328)1.62675947
150Small hand (HP:0200055)1.61903103
151Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61240263
152Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.60049913
153Periauricular skin pits (HP:0100277)1.59846549
154Preauricular pit (HP:0004467)1.59846549
155Patellar aplasia (HP:0006443)1.59208850
156Septo-optic dysplasia (HP:0100842)1.57069262
157Hypoplasia of the ulna (HP:0003022)1.56622585
158Abnormality of the 4th metacarpal (HP:0010012)1.56481125
159Aplasia/Hypoplasia of the patella (HP:0006498)1.56362452
160Cutaneous syndactyly (HP:0012725)1.54850622
161Congenital primary aphakia (HP:0007707)1.52878859
162Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.52727507
163Hyperaldosteronism (HP:0000859)1.52682529
164Abnormality of the 1st metacarpal (HP:0010009)1.52450131
165Adrenal hypoplasia (HP:0000835)1.51951259
166Aplasia/Hypoplasia of the fibula (HP:0006492)1.51396345
167Synostosis of carpal bones (HP:0005048)1.51210808
168Postaxial hand polydactyly (HP:0001162)1.50200040
169Morphological abnormality of the pyramidal tract (HP:0002062)1.50018274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.41895091
2NTRK34.26363844
3MAP3K94.01782730
4MARK13.28691216
5DAPK23.18544619
6MAP3K43.12260090
7KSR22.92957532
8MAP2K72.45179449
9MINK12.34757974
10KSR12.11152936
11WNK42.08773191
12MAP2K42.00541924
13MAP3K21.91028765
14PAK61.90734841
15PRKD31.83674234
16NTRK21.71458078
17DAPK11.70128879
18NTRK11.65494711
19ARAF1.61291430
20RIPK41.59728285
21EPHB21.57778433
22CAMKK11.54806442
23MAP3K121.51410003
24DYRK21.51005504
25STK391.50815285
26CAMK1D1.50780180
27MAPK131.50488416
28CDK51.41041433
29TAOK11.39888206
30CASK1.36642940
31MAP3K131.29420305
32SIK21.28639832
33STK381.26640803
34LATS21.23492016
35RET1.15624248
36TLK11.15489313
37PRPF4B1.14424565
38GRK51.13800685
39EPHA21.10531096
40LMTK21.09750572
41MAP4K21.07437246
42ICK1.07071724
43BMPR1B1.05576380
44TYRO31.02852566
45PRKCG1.02565371
46STK38L1.01496492
47RAF10.99419492
48GRK10.95639485
49PINK10.93807825
50CAMK2A0.92040200
51PLK20.90512000
52PTK2B0.90411851
53MAP3K60.90188055
54LATS10.88276860
55* SGK2230.87147160
56* SGK4940.87147160
57CAMKK20.85873729
58ADRBK20.83927870
59ERBB20.82677392
60BMPR20.82202606
61MAP2K10.81106355
62PIK3CA0.80976133
63WNK10.80904381
64* SGK20.80437012
65SIK30.79154175
66MAPK150.78685090
67FER0.77972794
68FES0.77330254
69MARK20.76936417
70* SGK30.76425639
71MAP3K10.74905482
72CAMK2B0.73980645
73CSNK1A1L0.73809835
74CDK180.72196970
75FRK0.71078164
76PHKG20.71036105
77PHKG10.71036105
78CAMK10.70979035
79PAK30.70896288
80AKT30.70500049
81PKN10.70411522
82UHMK10.68286279
83WNK30.67641335
84PRKCH0.66638683
85CDK140.66626756
86CDK150.66513964
87BRAF0.66035350
88* SGK10.65861718
89PRKCZ0.65838020
90PNCK0.65456868
91ACVR1B0.62533496
92STK110.60105941
93TNIK0.59552382
94CSNK1E0.58175441
95RPS6KA20.57999223
96CSNK1G20.56817308
97DYRK30.56784623
98PDPK10.55315703
99CSNK1G30.54392024
100FGFR20.53865897
101CAMK40.53856337
102CDK11A0.52426637
103OXSR10.52325327
104PDK10.52052715
105CSNK1G10.51137002
106MET0.50421051
107NEK10.48464912
108MKNK20.46552531
109RPS6KA30.46431544
110PRKCE0.45912114
111CAMK1G0.45318126
112DYRK1A0.45196490
113ERBB40.44843883
114MAPKAPK50.44648516
115DMPK0.44205230
116CSNK1A10.43702530
117* PRKACA0.43152932
118MAP3K70.42958566
119PTK20.41288814
120PRKAA20.40204722
121CDC42BPA0.39580411
122MOS0.39575933
123RIPK10.38997473
124FGFR10.37886713
125CAMK2G0.37877230
126GSK3B0.37743189
127CSNK1D0.37043799
128RPS6KB10.36413506
129MAPK100.36264131
130BCR0.35509595
131INSRR0.35403278
132CAMK2D0.31607108
133ROCK10.30409689
134PRKAA10.29947645
135PRKD20.29583742

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16688978
2Synaptic vesicle cycle_Homo sapiens_hsa047212.96051430
3Olfactory transduction_Homo sapiens_hsa047402.47085715
4Long-term potentiation_Homo sapiens_hsa047202.45928389
5Circadian entrainment_Homo sapiens_hsa047132.37165539
6Glutamatergic synapse_Homo sapiens_hsa047242.28598030
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.25072936
8GABAergic synapse_Homo sapiens_hsa047272.25026214
9Amphetamine addiction_Homo sapiens_hsa050312.21786657
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14294471
11Morphine addiction_Homo sapiens_hsa050322.07061685
12Dopaminergic synapse_Homo sapiens_hsa047281.99576334
13Insulin secretion_Homo sapiens_hsa049111.80815591
14Salivary secretion_Homo sapiens_hsa049701.79633854
15Cholinergic synapse_Homo sapiens_hsa047251.71327104
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67507304
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64019910
18Taste transduction_Homo sapiens_hsa047421.60153341
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58965989
20Gastric acid secretion_Homo sapiens_hsa049711.58878072
21* Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58748644
22Fatty acid biosynthesis_Homo sapiens_hsa000611.57806395
23Cocaine addiction_Homo sapiens_hsa050301.55915174
24Nitrogen metabolism_Homo sapiens_hsa009101.49799065
25Oxytocin signaling pathway_Homo sapiens_hsa049211.47685100
26GnRH signaling pathway_Homo sapiens_hsa049121.46982843
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.46097436
28Long-term depression_Homo sapiens_hsa047301.44914162
29Renin secretion_Homo sapiens_hsa049241.44480354
30Vitamin digestion and absorption_Homo sapiens_hsa049771.42675843
31Histidine metabolism_Homo sapiens_hsa003401.41408990
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39163692
33Steroid biosynthesis_Homo sapiens_hsa001001.38372459
34Serotonergic synapse_Homo sapiens_hsa047261.36484779
35Type II diabetes mellitus_Homo sapiens_hsa049301.34317948
36Calcium signaling pathway_Homo sapiens_hsa040201.33004977
37Gap junction_Homo sapiens_hsa045401.28691944
38Collecting duct acid secretion_Homo sapiens_hsa049661.21220873
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19830527
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16922878
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.16235910
42Linoleic acid metabolism_Homo sapiens_hsa005911.14923409
43Fat digestion and absorption_Homo sapiens_hsa049751.14143520
44Glioma_Homo sapiens_hsa052141.13322644
45cAMP signaling pathway_Homo sapiens_hsa040241.11065109
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09884968
47ErbB signaling pathway_Homo sapiens_hsa040121.08108298
48Retinol metabolism_Homo sapiens_hsa008301.07926729
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.07103919
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07012996
51Axon guidance_Homo sapiens_hsa043601.04983485
52Dorso-ventral axis formation_Homo sapiens_hsa043201.04791253
53Hippo signaling pathway_Homo sapiens_hsa043901.02266342
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01382323
55Estrogen signaling pathway_Homo sapiens_hsa049150.99721344
56Bile secretion_Homo sapiens_hsa049760.97862483
57Melanogenesis_Homo sapiens_hsa049160.95906970
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.95276331
59beta-Alanine metabolism_Homo sapiens_hsa004100.93838609
60ABC transporters_Homo sapiens_hsa020100.93757802
61Chemical carcinogenesis_Homo sapiens_hsa052040.92201370
62Choline metabolism in cancer_Homo sapiens_hsa052310.90090137
63Tryptophan metabolism_Homo sapiens_hsa003800.89095648
64Basal cell carcinoma_Homo sapiens_hsa052170.89034431
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88701973
66Butanoate metabolism_Homo sapiens_hsa006500.88229729
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88197696
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87830558
69Arginine biosynthesis_Homo sapiens_hsa002200.87678752
70Phototransduction_Homo sapiens_hsa047440.82395871
71Circadian rhythm_Homo sapiens_hsa047100.81475406
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80031718
73Hedgehog signaling pathway_Homo sapiens_hsa043400.79944379
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.79912828
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78325877
76Tight junction_Homo sapiens_hsa045300.77924989
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77436037
78Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77366575
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77303304
80Oocyte meiosis_Homo sapiens_hsa041140.77180688
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75930990
82Endometrial cancer_Homo sapiens_hsa052130.75298915
83Ether lipid metabolism_Homo sapiens_hsa005650.74963977
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.74459973
85Tyrosine metabolism_Homo sapiens_hsa003500.72538954
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72261316
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71681025
88Arginine and proline metabolism_Homo sapiens_hsa003300.71341055
89Propanoate metabolism_Homo sapiens_hsa006400.71302417
90Protein export_Homo sapiens_hsa030600.69772955
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69693712
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69412929
93VEGF signaling pathway_Homo sapiens_hsa043700.68862108
94Thyroid hormone synthesis_Homo sapiens_hsa049180.68256729
95Caffeine metabolism_Homo sapiens_hsa002320.67322378
96Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66910881
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66729974
98Pancreatic secretion_Homo sapiens_hsa049720.66298983
99Phenylalanine metabolism_Homo sapiens_hsa003600.65880915
100mTOR signaling pathway_Homo sapiens_hsa041500.65691799
101Starch and sucrose metabolism_Homo sapiens_hsa005000.65643982
102Fatty acid degradation_Homo sapiens_hsa000710.64475217
103Glucagon signaling pathway_Homo sapiens_hsa049220.63800461
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.63635969
105PPAR signaling pathway_Homo sapiens_hsa033200.63406984
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62664803
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61890672
108Vibrio cholerae infection_Homo sapiens_hsa051100.61271789
109Dilated cardiomyopathy_Homo sapiens_hsa054140.60119348
110MAPK signaling pathway_Homo sapiens_hsa040100.58883324
111Cardiac muscle contraction_Homo sapiens_hsa042600.58569928
112Insulin signaling pathway_Homo sapiens_hsa049100.58277638
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.56695387
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55847271
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55798495
116Rap1 signaling pathway_Homo sapiens_hsa040150.55592431
117Non-small cell lung cancer_Homo sapiens_hsa052230.55480257
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50621468
119Ras signaling pathway_Homo sapiens_hsa040140.50176382
120Prion diseases_Homo sapiens_hsa050200.49868209
121Renal cell carcinoma_Homo sapiens_hsa052110.49018298
122Adherens junction_Homo sapiens_hsa045200.48558203
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47566216
124Melanoma_Homo sapiens_hsa052180.47544093
125Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46791332
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46230639
127Inositol phosphate metabolism_Homo sapiens_hsa005620.45112225
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44690939
129Ovarian steroidogenesis_Homo sapiens_hsa049130.44074848
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42439652
131Prolactin signaling pathway_Homo sapiens_hsa049170.42366719
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.40164561
133* Endocytosis_Homo sapiens_hsa041440.39906430
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35851116
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.35459499
136Colorectal cancer_Homo sapiens_hsa052100.34182380
137Mineral absorption_Homo sapiens_hsa049780.33528114
138Glycerolipid metabolism_Homo sapiens_hsa005610.31582312
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30610277
140Wnt signaling pathway_Homo sapiens_hsa043100.30446992
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29285631
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.28957887

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