NEDD8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.87220321
2ATP synthesis coupled proton transport (GO:0015986)8.29381174
3energy coupled proton transport, down electrochemical gradient (GO:0015985)8.29381174
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.97998427
5respiratory electron transport chain (GO:0022904)6.37787833
6ribosomal small subunit biogenesis (GO:0042274)6.26436157
7electron transport chain (GO:0022900)6.22747249
8viral transcription (GO:0019083)6.06444422
9translational termination (GO:0006415)5.85279378
10chaperone-mediated protein transport (GO:0072321)5.54847513
11ribosomal small subunit assembly (GO:0000028)5.47047171
12cotranslational protein targeting to membrane (GO:0006613)5.33959137
13establishment of protein localization to mitochondrial membrane (GO:0090151)5.31365846
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.29226831
15protein targeting to ER (GO:0045047)5.24549211
16proteasome assembly (GO:0043248)5.14403882
17protein localization to endoplasmic reticulum (GO:0070972)5.00773820
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.99707879
19translational elongation (GO:0006414)4.98050998
20maturation of SSU-rRNA (GO:0030490)4.82126600
21cellular protein complex disassembly (GO:0043624)4.81320597
22viral life cycle (GO:0019058)4.76577962
23protein complex biogenesis (GO:0070271)4.62622708
24mitochondrial respiratory chain complex I assembly (GO:0032981)4.57688786
25NADH dehydrogenase complex assembly (GO:0010257)4.57688786
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.57688786
27negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.44942191
28translational initiation (GO:0006413)4.40865654
29establishment of integrated proviral latency (GO:0075713)4.37965362
30GTP biosynthetic process (GO:0006183)4.37542520
31ribosomal large subunit biogenesis (GO:0042273)4.34316938
32regulation of cellular amino acid metabolic process (GO:0006521)4.31270856
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.28284481
34mitochondrial respiratory chain complex assembly (GO:0033108)4.25831861
35translation (GO:0006412)4.22960198
36purine ribonucleoside triphosphate biosynthetic process (GO:0009206)4.14657122
37negative regulation of ligase activity (GO:0051352)4.13682647
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.13682647
39hydrogen ion transmembrane transport (GO:1902600)4.10650667
40termination of RNA polymerase III transcription (GO:0006386)4.09152621
41transcription elongation from RNA polymerase III promoter (GO:0006385)4.09152621
42ATP biosynthetic process (GO:0006754)4.08118436
43purine nucleoside triphosphate biosynthetic process (GO:0009145)4.05024543
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.04939505
45protein complex disassembly (GO:0043241)4.02892898
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.00456588
477-methylguanosine mRNA capping (GO:0006370)3.98962915
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.96904450
497-methylguanosine RNA capping (GO:0009452)3.93362799
50RNA capping (GO:0036260)3.93362799
51establishment of viral latency (GO:0019043)3.92879547
52intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.90998373
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.90998373
54regulation of mitochondrial translation (GO:0070129)3.89510746
55* protein neddylation (GO:0045116)3.88312290
56macromolecular complex disassembly (GO:0032984)3.88037954
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.85672226
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.85672226
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.85672226
60sequestering of actin monomers (GO:0042989)3.84768327
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.84400776
62establishment of protein localization to mitochondrion (GO:0072655)3.82680959
63protein targeting to mitochondrion (GO:0006626)3.81411403
64UTP biosynthetic process (GO:0006228)3.79625878
65cullin deneddylation (GO:0010388)3.76313948
66signal transduction involved in DNA damage checkpoint (GO:0072422)3.75261803
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.75261803
68anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.73158103
69antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.72452159
70signal transduction involved in cell cycle checkpoint (GO:0072395)3.71686585
71ribonucleoside triphosphate biosynthetic process (GO:0009201)3.69464148
72oxidative phosphorylation (GO:0006119)3.58978990
73proton transport (GO:0015992)3.56905634
74protein localization to mitochondrion (GO:0070585)3.54948223
75guanosine-containing compound biosynthetic process (GO:1901070)3.53635184
76protein targeting to membrane (GO:0006612)3.52512912
77protein deneddylation (GO:0000338)3.49728081
78hydrogen transport (GO:0006818)3.46996396
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.41806827
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.40555105
81tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.40555105
82regulation of cellular amine metabolic process (GO:0033238)3.40061679
83cellular component biogenesis (GO:0044085)3.39393974
84respiratory chain complex IV assembly (GO:0008535)3.37331267
85inner mitochondrial membrane organization (GO:0007007)3.35156119
86ribonucleoprotein complex biogenesis (GO:0022613)3.34397472
87positive regulation of ligase activity (GO:0051351)3.31437137
88nucleoside triphosphate biosynthetic process (GO:0009142)3.26738668
89dopamine transport (GO:0015872)3.20881696
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.19946737
91protein-cofactor linkage (GO:0018065)3.18400121
92cytochrome complex assembly (GO:0017004)3.17107563
93UTP metabolic process (GO:0046051)3.16554920
94behavioral response to nicotine (GO:0035095)3.15990386
95CTP metabolic process (GO:0046036)3.13471617
96CTP biosynthetic process (GO:0006241)3.13471617
97spliceosomal snRNP assembly (GO:0000387)3.10756913
98intracellular protein transmembrane import (GO:0044743)3.07895541
99nuclear-transcribed mRNA catabolic process (GO:0000956)3.06594597
100spliceosomal complex assembly (GO:0000245)3.03991365
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03933249
102mitochondrial transport (GO:0006839)3.01959595
103positive regulation of cell cycle arrest (GO:0071158)3.01901824
104water-soluble vitamin biosynthetic process (GO:0042364)3.01423595
105DNA deamination (GO:0045006)3.00496115
106mRNA catabolic process (GO:0006402)2.97548935
107regulation of ubiquitin-protein transferase activity (GO:0051438)2.97357721
108DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.95411974
109platelet dense granule organization (GO:0060155)2.95185593
110chromatin remodeling at centromere (GO:0031055)2.84417202
111regulation of cilium movement (GO:0003352)2.80670613
112purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.78137784
113purine nucleoside monophosphate biosynthetic process (GO:0009127)2.78137784
114DNA damage response, detection of DNA damage (GO:0042769)2.72120084
115aerobic respiration (GO:0009060)2.71828577
116protein targeting (GO:0006605)2.71817698
117rRNA modification (GO:0000154)2.68787456
118RNA catabolic process (GO:0006401)2.67195933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.21659391
2* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.94438585
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.81192941
4* EST1_17652178_ChIP-ChIP_JURKAT_Human4.47436586
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.95687403
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.91708651
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.83265638
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.73159250
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.61711437
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.56313984
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.53343699
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.48798645
13* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.48204069
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.37400571
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.32219169
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80928340
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51011951
18* VDR_23849224_ChIP-Seq_CD4+_Human2.45364504
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42743728
20XRN2_22483619_ChIP-Seq_HELA_Human2.42727324
21DCP1A_22483619_ChIP-Seq_HELA_Human2.39643821
22ELK1_19687146_ChIP-ChIP_HELA_Human2.38567156
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31970218
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.31173127
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.29351326
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25868400
27TTF2_22483619_ChIP-Seq_HELA_Human2.22495300
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18222030
29YY1_21170310_ChIP-Seq_MESCs_Mouse2.15209950
30ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.00864343
31CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.97638272
32FOXP3_21729870_ChIP-Seq_TREG_Human1.96136641
33ELK1_22589737_ChIP-Seq_MCF10A_Human1.91072428
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79310594
35* GABP_19822575_ChIP-Seq_HepG2_Human1.75097406
36ZNF274_21170338_ChIP-Seq_K562_Hela1.72317036
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72246672
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60828868
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.60808044
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59661975
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53299566
42MYC_18940864_ChIP-ChIP_HL60_Human1.51336256
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48494758
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44768077
45EZH2_22144423_ChIP-Seq_EOC_Human1.39515345
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35851125
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30929883
48VDR_22108803_ChIP-Seq_LS180_Human1.30918516
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27278660
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25494542
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24909781
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24880995
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23776343
54CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.23581913
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21575993
56KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20425591
57* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19640629
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17869483
59CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17461146
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15425232
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.14901613
62IRF1_19129219_ChIP-ChIP_H3396_Human1.14178828
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12880251
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12788937
65NANOG_16153702_ChIP-ChIP_HESCs_Human1.08061390
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07208189
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06608569
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04652733
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03362812
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03275359
71FUS_26573619_Chip-Seq_HEK293_Human1.02824848
72CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02438999
73TAF15_26573619_Chip-Seq_HEK293_Human1.02033016
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01968112
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01637677
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99431143
77SOX17_20123909_ChIP-Seq_XEN_Mouse0.98915796
78* TP53_22573176_ChIP-Seq_HFKS_Human0.97672865
79MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95695333
80ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93663212
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92413887
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90112353
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87528728
84* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86961108
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.86850203
86KDM5A_27292631_Chip-Seq_BREAST_Human0.85986554
87E2F7_22180533_ChIP-Seq_HELA_Human0.84951620
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.84908811
89POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84903648
90GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84603033
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84596609
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84145097
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81349401
94* FOXP1_21924763_ChIP-Seq_HESCs_Human0.80953922
95FOXA1_25329375_ChIP-Seq_VCAP_Human0.80415382
96FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80415382
97RNF2_27304074_Chip-Seq_NSC_Mouse0.79564969
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.78682213
99SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77974627
100* HTT_18923047_ChIP-ChIP_STHdh_Human0.76032515
101* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.75982837
102RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75932114
103FLI1_27457419_Chip-Seq_LIVER_Mouse0.75882530
104P300_19829295_ChIP-Seq_ESCs_Human0.75828782
105EZH2_27304074_Chip-Seq_ESCs_Mouse0.75466150
106STAT1_20625510_ChIP-Seq_HELA_Human0.75132364
107REST_21632747_ChIP-Seq_MESCs_Mouse0.73921711
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.73403450
109CTBP2_25329375_ChIP-Seq_LNCAP_Human0.73344662
110EWS_26573619_Chip-Seq_HEK293_Human0.73202864
111REST_18959480_ChIP-ChIP_MESCs_Mouse0.73154862
112RBPJ_22232070_ChIP-Seq_NCS_Mouse0.73089106
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71309616
114EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.71194829
115SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69451224
116CIITA_25753668_ChIP-Seq_RAJI_Human0.69326207
117MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69222440
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68742981
119CBX2_27304074_Chip-Seq_ESCs_Mouse0.68018088
120* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.66947826
121IGF1R_20145208_ChIP-Seq_DFB_Human0.66813077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.22802846
2MP0003880_abnormal_central_pattern4.08152427
3MP0001529_abnormal_vocalization3.90398987
4MP0010030_abnormal_orbit_morphology3.32132072
5MP0001905_abnormal_dopamine_level3.28499051
6MP0006276_abnormal_autonomic_nervous3.18404379
7MP0002638_abnormal_pupillary_reflex2.44055714
8MP0002736_abnormal_nociception_after2.42975717
9MP0002653_abnormal_ependyma_morphology2.29445050
10MP0001968_abnormal_touch/_nociception2.25013449
11MP0003011_delayed_dark_adaptation2.16299877
12MP0003693_abnormal_embryo_hatching2.04861074
13MP0002163_abnormal_gland_morphology2.01928842
14MP0002735_abnormal_chemical_nociception1.97302347
15MP0001293_anophthalmia1.91998930
16MP0004142_abnormal_muscle_tone1.91630870
17MP0004957_abnormal_blastocyst_morpholog1.89268607
18MP0006035_abnormal_mitochondrial_morpho1.88972190
19MP0003121_genomic_imprinting1.87740925
20MP0002102_abnormal_ear_morphology1.87193446
21MP0008932_abnormal_embryonic_tissue1.85140920
22MP0006036_abnormal_mitochondrial_physio1.84533056
23MP0003787_abnormal_imprinting1.82297476
24MP0003136_yellow_coat_color1.81140668
25MP0001188_hyperpigmentation1.79425553
26MP0001986_abnormal_taste_sensitivity1.72694129
27MP0002938_white_spotting1.67121434
28MP0002734_abnormal_mechanical_nocicepti1.66090725
29MP0000372_irregular_coat_pigmentation1.62670185
30MP0001440_abnormal_grooming_behavior1.60666896
31MP0010386_abnormal_urinary_bladder1.57106106
32MP0003806_abnormal_nucleotide_metabolis1.56110134
33MP0001970_abnormal_pain_threshold1.55708476
34MP0001727_abnormal_embryo_implantation1.55224717
35MP0002733_abnormal_thermal_nociception1.53357853
36MP0002272_abnormal_nervous_system1.51345214
37MP0005409_darkened_coat_color1.50688251
38MP0005551_abnormal_eye_electrophysiolog1.49798522
39MP0002837_dystrophic_cardiac_calcinosis1.48001511
40MP0002751_abnormal_autonomic_nervous1.47792927
41MP0002064_seizures1.47769867
42MP0003186_abnormal_redox_activity1.47111847
43MP0008789_abnormal_olfactory_epithelium1.43775821
44MP0003122_maternal_imprinting1.43198775
45MP0009745_abnormal_behavioral_response1.40532854
46MP0005423_abnormal_somatic_nervous1.39710959
47MP0003718_maternal_effect1.39610310
48MP0008877_abnormal_DNA_methylation1.36233827
49MP0009046_muscle_twitch1.34791584
50MP0003315_abnormal_perineum_morphology1.31217763
51MP0003786_premature_aging1.30589004
52MP0006292_abnormal_olfactory_placode1.26222103
53MP0002572_abnormal_emotion/affect_behav1.24891323
54MP0005379_endocrine/exocrine_gland_phen1.23479961
55MP0008057_abnormal_DNA_replication1.21734997
56MP0002184_abnormal_innervation1.20777117
57MP0002234_abnormal_pharynx_morphology1.17572251
58MP0002233_abnormal_nose_morphology1.16968482
59MP0001984_abnormal_olfaction1.15972394
60MP0003635_abnormal_synaptic_transmissio1.12863352
61MP0002067_abnormal_sensory_capabilities1.12694983
62MP0004742_abnormal_vestibular_system1.11756388
63MP0001286_abnormal_eye_development1.11124898
64MP0008875_abnormal_xenobiotic_pharmacok1.10909896
65MP0003890_abnormal_embryonic-extraembry1.10231956
66MP0005394_taste/olfaction_phenotype1.10019083
67MP0005499_abnormal_olfactory_system1.10019083
68MP0008058_abnormal_DNA_repair1.09931109
69MP0004270_analgesia1.09066567
70MP0005408_hypopigmentation1.08729191
71MP0005195_abnormal_posterior_eye1.08022246
72MP0003077_abnormal_cell_cycle1.07836031
73MP0002160_abnormal_reproductive_system1.06434590
74MP0006072_abnormal_retinal_apoptosis1.04978544
75MP0003123_paternal_imprinting1.02296834
76MP0002148_abnormal_hypersensitivity_rea1.01677128
77MP0005253_abnormal_eye_physiology1.01629976
78MP0001485_abnormal_pinna_reflex1.00986568
79MP0005646_abnormal_pituitary_gland0.98415294
80MP0000778_abnormal_nervous_system0.97175639
81MP0000955_abnormal_spinal_cord0.95844984
82MP0005386_behavior/neurological_phenoty0.93798129
83MP0004924_abnormal_behavior0.93798129
84MP0002063_abnormal_learning/memory/cond0.93493140
85MP0005171_absent_coat_pigmentation0.93291842
86MP0003195_calcinosis0.90536502
87MP0003878_abnormal_ear_physiology0.89010018
88MP0005377_hearing/vestibular/ear_phenot0.89010018
89MP0000049_abnormal_middle_ear0.88918814
90MP0004147_increased_porphyrin_level0.86640099
91MP0002277_abnormal_respiratory_mucosa0.86458773
92MP0010094_abnormal_chromosome_stability0.86239795
93MP0003937_abnormal_limbs/digits/tail_de0.84572788
94MP0002752_abnormal_somatic_nervous0.83971180
95MP0002210_abnormal_sex_determination0.82827557
96MP0004133_heterotaxia0.82004367
97MP0002132_abnormal_respiratory_system0.81484860
98MP0003283_abnormal_digestive_organ0.80972987
99MP0005391_vision/eye_phenotype0.80019572
100MP0003942_abnormal_urinary_system0.79214451
101MP0002822_catalepsy0.79189898
102MP0000026_abnormal_inner_ear0.78675861
103MP0008872_abnormal_physiological_respon0.78371133
104MP0002090_abnormal_vision0.78342726
105MP0001486_abnormal_startle_reflex0.78124484
106MP0002876_abnormal_thyroid_physiology0.77073553
107MP0003938_abnormal_ear_development0.75922794
108MP0000358_abnormal_cell_content/0.75068387
109MP0003755_abnormal_palate_morphology0.74993931
110MP0001324_abnormal_eye_pigmentation0.74969737
111MP0001501_abnormal_sleep_pattern0.74793058
112MP0001963_abnormal_hearing_physiology0.74745334
113MP0004145_abnormal_muscle_electrophysio0.73892982
114MP0000538_abnormal_urinary_bladder0.73288150
115MP0009697_abnormal_copulation0.72566718
116MP0001542_abnormal_bone_strength0.72432300
117MP0004885_abnormal_endolymph0.72341515
118MP0004019_abnormal_vitamin_homeostasis0.70668903
119MP0004381_abnormal_hair_follicle0.70107681
120MP0002557_abnormal_social/conspecific_i0.69545516
121MP0005084_abnormal_gallbladder_morpholo0.68987678
122MP0009333_abnormal_splenocyte_physiolog0.68898940
123MP0005389_reproductive_system_phenotype0.68596904
124MP0002332_abnormal_exercise_endurance0.66231057
125MP0002882_abnormal_neuron_morphology0.65508400
126MP0002066_abnormal_motor_capabilities/c0.65493859
127MP0000631_abnormal_neuroendocrine_gland0.65035511
128MP0000749_muscle_degeneration0.63471433
129MP0000015_abnormal_ear_pigmentation0.62708641
130MP0000566_synostosis0.61272639
131MP0008995_early_reproductive_senescence0.60695938

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)7.21498929
2Mitochondrial inheritance (HP:0001427)6.49505826
3Abnormal mitochondria in muscle tissue (HP:0008316)6.44013448
4Progressive macrocephaly (HP:0004481)6.08808315
5Acute encephalopathy (HP:0006846)5.59907375
6Increased CSF lactate (HP:0002490)5.49151639
7Hepatocellular necrosis (HP:0001404)5.43474696
8Increased hepatocellular lipid droplets (HP:0006565)5.38353958
9Abnormality of cells of the erythroid lineage (HP:0012130)5.23607441
10Abnormal number of erythroid precursors (HP:0012131)4.69826920
11Lipid accumulation in hepatocytes (HP:0006561)4.68318109
12Renal Fanconi syndrome (HP:0001994)4.67723039
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.53227309
14Hepatic necrosis (HP:0002605)4.49195845
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.20942523
16Reticulocytopenia (HP:0001896)3.92220556
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.88250856
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.88250856
19Exertional dyspnea (HP:0002875)3.82017075
20Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.81309262
213-Methylglutaconic aciduria (HP:0003535)3.80294245
22Exercise intolerance (HP:0003546)3.78258172
23Increased intramyocellular lipid droplets (HP:0012240)3.74675016
24Abnormality of glycolysis (HP:0004366)3.73630631
25Increased serum pyruvate (HP:0003542)3.73630631
26Respiratory failure (HP:0002878)3.73225011
27Cerebral edema (HP:0002181)3.58875909
28Optic disc pallor (HP:0000543)3.58086951
29Increased serum lactate (HP:0002151)3.50237762
30Leukodystrophy (HP:0002415)3.50203445
31Macrocytic anemia (HP:0001972)3.49744236
32Lactic acidosis (HP:0003128)3.32184893
33Respiratory difficulties (HP:0002880)3.17113667
34Septo-optic dysplasia (HP:0100842)3.07720430
35Molar tooth sign on MRI (HP:0002419)3.05843841
36Abnormality of midbrain morphology (HP:0002418)3.05843841
37Pallor (HP:0000980)3.03285564
38Parakeratosis (HP:0001036)3.02093023
39Increased muscle lipid content (HP:0009058)2.99222241
40Rib fusion (HP:0000902)2.98128116
41Abnormality of renal resorption (HP:0011038)2.92842639
42Emotional lability (HP:0000712)2.51929016
43Congenital ichthyosiform erythroderma (HP:0007431)2.50238770
44Congenital, generalized hypertrichosis (HP:0004540)2.47480070
45Nephronophthisis (HP:0000090)2.46852965
46Neuroendocrine neoplasm (HP:0100634)2.36892481
47X-linked dominant inheritance (HP:0001423)2.33813202
48Abnormality of the labia minora (HP:0012880)2.33672374
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.33671216
50Colon cancer (HP:0003003)2.28193118
51Hyperglycinemia (HP:0002154)2.28117941
52Cerebral hypomyelination (HP:0006808)2.27369830
53CNS demyelination (HP:0007305)2.26100874
54Limb dystonia (HP:0002451)2.25814704
55Hypothermia (HP:0002045)2.25071826
56Absent septum pellucidum (HP:0001331)2.18744547
57Hyperphosphaturia (HP:0003109)2.16572448
58Aplastic anemia (HP:0001915)2.16206189
59Abnormality of placental membranes (HP:0011409)2.15227218
60Amniotic constriction ring (HP:0009775)2.15227218
61Bifid tongue (HP:0010297)2.12339940
62Myokymia (HP:0002411)2.12165665
63Abnormal pupillary function (HP:0007686)2.09187653
64Methylmalonic acidemia (HP:0002912)2.07528587
65Pheochromocytoma (HP:0002666)2.06005555
66Absent thumb (HP:0009777)2.03265024
67Adrenal hypoplasia (HP:0000835)2.02902711
68Methylmalonic aciduria (HP:0012120)2.02445103
69Medial flaring of the eyebrow (HP:0010747)1.96559951
70Delusions (HP:0000746)1.96304195
71Anophthalmia (HP:0000528)1.95060641
72Generalized aminoaciduria (HP:0002909)1.94562099
73Aplasia/hypoplasia of the uterus (HP:0008684)1.92416822
74Abnormality of urine glucose concentration (HP:0011016)1.91712178
75Glycosuria (HP:0003076)1.91712178
76Breast hypoplasia (HP:0003187)1.91222722
77Anencephaly (HP:0002323)1.90755911
78Abnormality of the renal medulla (HP:0100957)1.89391413
79Optic nerve hypoplasia (HP:0000609)1.85954198
80Growth hormone deficiency (HP:0000824)1.84761373
81Genital tract atresia (HP:0001827)1.81313123
82Oral leukoplakia (HP:0002745)1.80120426
83Microvesicular hepatic steatosis (HP:0001414)1.80019237
84Blindness (HP:0000618)1.79862557
85Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.79170560
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.79154079
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.77997035
88Renal tubular dysfunction (HP:0000124)1.74835659
89Abnormal urine phosphate concentration (HP:0012599)1.74679909
90Type I transferrin isoform profile (HP:0003642)1.70976271
91Stenosis of the external auditory canal (HP:0000402)1.70877121
92Supernumerary spleens (HP:0009799)1.70870281
93Gait imbalance (HP:0002141)1.69469388
94Congenital primary aphakia (HP:0007707)1.68769780
95Abnormal hair whorl (HP:0010721)1.65028979
96Meckel diverticulum (HP:0002245)1.64328387
97Pendular nystagmus (HP:0012043)1.64298654
98Abnormality of secondary sexual hair (HP:0009888)1.64269791
99Abnormality of the axillary hair (HP:0100134)1.64269791
100Abnormal hemoglobin (HP:0011902)1.62906584
101Abnormality of the septum pellucidum (HP:0007375)1.61924945
102Gliosis (HP:0002171)1.61420269
103Birth length less than 3rd percentile (HP:0003561)1.60028272
104Congenital stationary night blindness (HP:0007642)1.59096141
105Sensory axonal neuropathy (HP:0003390)1.58938782
106Rough bone trabeculation (HP:0100670)1.58779626
107Poor suck (HP:0002033)1.58622815
108Male pseudohermaphroditism (HP:0000037)1.57781359
109Progressive external ophthalmoplegia (HP:0000590)1.56895770
110Nephrogenic diabetes insipidus (HP:0009806)1.56803876
111Abnormal autonomic nervous system physiology (HP:0012332)1.56341762
112Pancytopenia (HP:0001876)1.55934047
113Concave nail (HP:0001598)1.55154019
114Cystic liver disease (HP:0006706)1.54755047
115Cerebral hemorrhage (HP:0001342)1.54525142
116Abnormality of the ileum (HP:0001549)1.54308627
117Triphalangeal thumb (HP:0001199)1.53901705
118Retinal dysplasia (HP:0007973)1.53548041
119Delayed CNS myelination (HP:0002188)1.53213604
120Conjunctival hamartoma (HP:0100780)1.53078265
121Maternal diabetes (HP:0009800)1.52704172
122CNS hypomyelination (HP:0003429)1.52643881
123Hemivertebrae (HP:0002937)1.52294251
124Lethargy (HP:0001254)1.50917531
125Esotropia (HP:0000565)1.50778038
126True hermaphroditism (HP:0010459)1.50644845
127Pancreatic fibrosis (HP:0100732)1.48644697
128Pancreatic cysts (HP:0001737)1.47970828
129Sclerocornea (HP:0000647)1.46656648
130Irregular epiphyses (HP:0010582)1.45949316
131Vaginal atresia (HP:0000148)1.44358903
132Carpal bone hypoplasia (HP:0001498)1.44066713
133Glossoptosis (HP:0000162)1.43881233
134Hypokinesia (HP:0002375)1.42999045
135Unsteady gait (HP:0002317)1.42481146
136Neoplasm of head and neck (HP:0012288)1.41154880
137Esophageal neoplasm (HP:0100751)1.41154880
138Depressed nasal ridge (HP:0000457)1.40571340
139Postnatal microcephaly (HP:0005484)1.40382916

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.59509231
2BUB13.43504488
3NME23.40220286
4NME13.31438884
5MAP3K123.30183696
6STK163.29511422
7ARAF2.81189145
8MST42.48846025
9PBK2.41705233
10PIM22.30631458
11VRK12.29781587
12ZAK2.24918858
13LIMK12.14511954
14WEE11.98324275
15PNCK1.95948935
16CASK1.90967680
17SRPK11.89591449
18TRIM281.87711145
19MYLK1.85495134
20BCKDK1.78233351
21CDK191.77651849
22TLK11.74829001
23EIF2AK11.72962384
24BRAF1.69224541
25GRK51.67994779
26NUAK11.66150779
27MAP4K21.65444524
28EIF2AK31.64887654
29TESK21.54758823
30TAF11.49101073
31NEK11.39978913
32TSSK61.38456864
33GRK71.37977071
34GRK11.34413541
35EPHB21.33986821
36TESK11.33563357
37BMPR1B1.33400330
38PDK21.32662213
39PLK41.28556611
40MAP3K91.27269734
41BCR1.26335935
42STK391.22476010
43MAPKAPK51.20887186
44PINK11.20578039
45DYRK21.20449923
46PLK21.19548888
47TNIK1.17446836
48MAP2K71.15346358
49BMPR21.14293358
50RIPK41.12754389
51AURKA1.11155133
52ADRBK21.07709652
53EPHA41.06415374
54ABL21.06377633
55OXSR11.00707112
56ILK0.98081825
57KDR0.98075742
58MUSK0.97293794
59CSNK1G30.96598956
60MKNK10.95569984
61MAPK130.92150416
62UHMK10.90731994
63BRSK10.87504346
64PLK30.81779989
65MAP3K110.81687150
66ACVR1B0.77320636
67INSRR0.75479539
68DAPK30.74994655
69TTK0.74453677
70ADRBK10.74320260
71MARK10.71854811
72MINK10.70309538
73NTRK20.70051389
74CDK80.67431752
75CSNK2A10.67428323
76CDC70.67305024
77PAK10.66926598
78CDK140.66338276
79CAMK2B0.65817723
80PHKG10.64525407
81PHKG20.64525407
82CCNB10.64450843
83PAK30.64220239
84CSNK1A1L0.63088521
85OBSCN0.63001111
86CSNK2A20.62760150
87IRAK40.61478489
88FGR0.59430256
89RPS6KA50.58156415
90RAF10.56910551
91PLK10.56562773
92NEK20.54575746
93CDK180.54508245
94CDK11A0.53983938
95DAPK10.53297498
96GRK60.52599163
97CAMK2A0.51530127
98CDK150.50506633
99SIK30.50204303
100WNK40.49789943
101CHEK20.49339478
102CSNK1E0.49251851
103ROCK20.48525926
104CSNK1G20.46515092
105FGFR20.45238421
106PIK3CA0.45222938
107EIF2AK20.44831011
108CAMK2D0.44750933
109IRAK20.44498424
110YES10.44463415
111MAP3K40.44356477
112RPS6KB20.43627765
113PRKCG0.43390616
114CAMK2G0.42956387
115TIE10.42783505
116ATR0.42737123
117AURKB0.41987988
118CSNK1G10.41798914
119PRKCI0.41043678
120FRK0.40804206
121CSNK1A10.40782740
122MKNK20.40183036
123SYK0.36657388
124NTRK30.36447053
125BLK0.35453986
126LRRK20.35412866
127WNK30.34636429
128PRKCE0.34604190
129DYRK30.33521882
130FES0.32305366
131PRKACA0.32002295

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.82558721
2Ribosome_Homo sapiens_hsa030105.28197011
3Parkinsons disease_Homo sapiens_hsa050125.03417121
4Proteasome_Homo sapiens_hsa030504.89337924
5Huntingtons disease_Homo sapiens_hsa050163.69291216
6Alzheimers disease_Homo sapiens_hsa050103.68768026
7RNA polymerase_Homo sapiens_hsa030203.34402439
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.00468612
9Protein export_Homo sapiens_hsa030602.63809134
10Cardiac muscle contraction_Homo sapiens_hsa042602.29013213
11DNA replication_Homo sapiens_hsa030301.93742100
12Collecting duct acid secretion_Homo sapiens_hsa049661.92061073
13Pyrimidine metabolism_Homo sapiens_hsa002401.90272004
14Spliceosome_Homo sapiens_hsa030401.88211278
15Mismatch repair_Homo sapiens_hsa034301.69553069
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54626317
17Nucleotide excision repair_Homo sapiens_hsa034201.53761291
18Homologous recombination_Homo sapiens_hsa034401.40507497
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33062766
20Vibrio cholerae infection_Homo sapiens_hsa051101.30436174
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28829733
22Basal transcription factors_Homo sapiens_hsa030221.21034901
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13235471
24RNA transport_Homo sapiens_hsa030131.07597298
25One carbon pool by folate_Homo sapiens_hsa006701.07373154
26Purine metabolism_Homo sapiens_hsa002301.05427817
27Propanoate metabolism_Homo sapiens_hsa006401.05102445
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.04387133
29Butanoate metabolism_Homo sapiens_hsa006501.03965041
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98307159
31Base excision repair_Homo sapiens_hsa034100.97477003
32RNA degradation_Homo sapiens_hsa030180.97408812
33Peroxisome_Homo sapiens_hsa041460.95921690
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94543565
35Rheumatoid arthritis_Homo sapiens_hsa053230.93686783
36Synaptic vesicle cycle_Homo sapiens_hsa047210.88368876
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78449059
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77341776
39Nicotine addiction_Homo sapiens_hsa050330.76968109
40Glutathione metabolism_Homo sapiens_hsa004800.76876309
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75263763
42Epstein-Barr virus infection_Homo sapiens_hsa051690.72270188
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71894544
44Non-homologous end-joining_Homo sapiens_hsa034500.71756864
45Phagosome_Homo sapiens_hsa041450.70700213
46Serotonergic synapse_Homo sapiens_hsa047260.68366169
47Fatty acid elongation_Homo sapiens_hsa000620.67384110
48Tryptophan metabolism_Homo sapiens_hsa003800.67037294
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67028768
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65430731
51Metabolic pathways_Homo sapiens_hsa011000.62937702
52Nitrogen metabolism_Homo sapiens_hsa009100.62514635
53Fanconi anemia pathway_Homo sapiens_hsa034600.60798532
54Phototransduction_Homo sapiens_hsa047440.59851274
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59850775
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59823732
57Basal cell carcinoma_Homo sapiens_hsa052170.57214460
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57175122
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55646137
60Graft-versus-host disease_Homo sapiens_hsa053320.54369294
61Selenocompound metabolism_Homo sapiens_hsa004500.54113151
62Chemical carcinogenesis_Homo sapiens_hsa052040.53098377
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52947987
64Asthma_Homo sapiens_hsa053100.52732669
65Cell cycle_Homo sapiens_hsa041100.51785388
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50892438
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.50785573
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50679004
69Arachidonic acid metabolism_Homo sapiens_hsa005900.49681680
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48847209
71Hedgehog signaling pathway_Homo sapiens_hsa043400.48442642
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.48088373
73Autoimmune thyroid disease_Homo sapiens_hsa053200.47511162
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46678998
75Allograft rejection_Homo sapiens_hsa053300.46564059
76beta-Alanine metabolism_Homo sapiens_hsa004100.43631546
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41443465
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41073086
79Ether lipid metabolism_Homo sapiens_hsa005650.41045726
80Sulfur relay system_Homo sapiens_hsa041220.39054099
81Alcoholism_Homo sapiens_hsa050340.38141896
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37854304
83N-Glycan biosynthesis_Homo sapiens_hsa005100.36404819
84Fat digestion and absorption_Homo sapiens_hsa049750.35711543
85Fatty acid degradation_Homo sapiens_hsa000710.35709823
86Tyrosine metabolism_Homo sapiens_hsa003500.35492926
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35158636
88Biosynthesis of amino acids_Homo sapiens_hsa012300.34895293
89Phenylalanine metabolism_Homo sapiens_hsa003600.34218093
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34201120
91Retinol metabolism_Homo sapiens_hsa008300.33116446
92Oocyte meiosis_Homo sapiens_hsa041140.32426633
93Regulation of autophagy_Homo sapiens_hsa041400.32065171
94Systemic lupus erythematosus_Homo sapiens_hsa053220.31477478
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.31457556
96Fatty acid metabolism_Homo sapiens_hsa012120.31385734
97Steroid biosynthesis_Homo sapiens_hsa001000.31015221
98Type I diabetes mellitus_Homo sapiens_hsa049400.28807863
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27688618
100Mineral absorption_Homo sapiens_hsa049780.27302025
101Caffeine metabolism_Homo sapiens_hsa002320.27204649
102Pyruvate metabolism_Homo sapiens_hsa006200.27033730
103Olfactory transduction_Homo sapiens_hsa047400.27028255
104Taste transduction_Homo sapiens_hsa047420.26250592
105Linoleic acid metabolism_Homo sapiens_hsa005910.26190684
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25444906
107Folate biosynthesis_Homo sapiens_hsa007900.24423340
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24366614
109Vitamin digestion and absorption_Homo sapiens_hsa049770.23606427
110Dopaminergic synapse_Homo sapiens_hsa047280.22921434
111Long-term depression_Homo sapiens_hsa047300.20820553
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.20193830
113GABAergic synapse_Homo sapiens_hsa047270.19872755
114Sphingolipid metabolism_Homo sapiens_hsa006000.19018933
115Sulfur metabolism_Homo sapiens_hsa009200.17872682
116Vitamin B6 metabolism_Homo sapiens_hsa007500.17082069
117Shigellosis_Homo sapiens_hsa051310.17068837
118African trypanosomiasis_Homo sapiens_hsa051430.16075967
119mRNA surveillance pathway_Homo sapiens_hsa030150.15206101
120Amphetamine addiction_Homo sapiens_hsa050310.13834557
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13227157
122p53 signaling pathway_Homo sapiens_hsa041150.12202578
123Pertussis_Homo sapiens_hsa051330.11700751
124Morphine addiction_Homo sapiens_hsa050320.11189953
125Pentose phosphate pathway_Homo sapiens_hsa000300.10100719
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.10004174
127Salmonella infection_Homo sapiens_hsa051320.09214858
128Hematopoietic cell lineage_Homo sapiens_hsa046400.05655935
129Arginine and proline metabolism_Homo sapiens_hsa003300.05154249
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.04604673
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.04141888
132Glutamatergic synapse_Homo sapiens_hsa047240.03337109
133Cocaine addiction_Homo sapiens_hsa050300.02823525
134Carbon metabolism_Homo sapiens_hsa012000.02791585
135Cholinergic synapse_Homo sapiens_hsa047250.02613261
136Legionellosis_Homo sapiens_hsa051340.00916363
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.00902982
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.00044974
139Gap junction_Homo sapiens_hsa045400.00040964

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