NEDD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)4.84970548
2positive regulation of gamma-delta T cell activation (GO:0046645)4.83521585
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.69582062
4antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69582062
5positive thymic T cell selection (GO:0045059)4.30514238
6regulation of gamma-delta T cell differentiation (GO:0045586)4.03271670
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.00288920
8regulation of B cell receptor signaling pathway (GO:0050855)3.99571261
9substrate-dependent cell migration (GO:0006929)3.95994291
10leukocyte aggregation (GO:0070486)3.89179700
11morphogenesis of an endothelium (GO:0003159)3.88519961
12endothelial tube morphogenesis (GO:0061154)3.88519961
13B cell receptor signaling pathway (GO:0050853)3.84304095
14negative thymic T cell selection (GO:0045060)3.77049436
15regulation of gamma-delta T cell activation (GO:0046643)3.74804781
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.72953861
17negative T cell selection (GO:0043383)3.70148463
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.65084157
19regulation of T cell tolerance induction (GO:0002664)3.63315535
20negative regulation of fibrinolysis (GO:0051918)3.61552612
21thymic T cell selection (GO:0045061)3.57103696
22negative regulation of protein activation cascade (GO:2000258)3.44653478
23tolerance induction (GO:0002507)3.41921127
24hepatocyte apoptotic process (GO:0097284)3.41638635
25negative regulation of complement activation (GO:0045916)3.40457437
26lymph vessel development (GO:0001945)3.32286548
27positive T cell selection (GO:0043368)3.31649656
28positive regulation of tolerance induction (GO:0002645)3.25146559
29cellular extravasation (GO:0045123)3.23595582
30T cell selection (GO:0045058)3.21333195
31response to interleukin-15 (GO:0070672)3.19059858
32cellular response to zinc ion (GO:0071294)3.14894835
33vascular endothelial growth factor signaling pathway (GO:0038084)3.14544663
34membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.13942849
35regulation of B cell differentiation (GO:0045577)3.12664710
36cell proliferation involved in metanephros development (GO:0072203)3.11900781
37JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.06554934
38regulation of complement activation (GO:0030449)3.01287808
39negative regulation of cell killing (GO:0031342)3.01085715
40negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.01085715
41regulation of tolerance induction (GO:0002643)2.96751313
42intestinal cholesterol absorption (GO:0030299)2.96399893
43regulation of protein activation cascade (GO:2000257)2.94151596
44T cell costimulation (GO:0031295)2.91183945
45leukocyte cell-cell adhesion (GO:0007159)2.90508424
46negative regulation of protein autophosphorylation (GO:0031953)2.89252294
47negative regulation of humoral immune response (GO:0002921)2.88399685
48cellular response to interleukin-15 (GO:0071350)2.88055909
49regulation of alpha-beta T cell proliferation (GO:0046640)2.86800243
50negative regulation of phagocytosis (GO:0050765)2.85838256
51lymphocyte costimulation (GO:0031294)2.84024050
52regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.83692909
53positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82582333
54positive regulation of histone deacetylation (GO:0031065)2.82517829
55sulfation (GO:0051923)2.79802300
56cell proliferation involved in kidney development (GO:0072111)2.79395249
57establishment of endothelial barrier (GO:0061028)2.76768064
58regulation of glomerulus development (GO:0090192)2.74447990
59membrane repolarization during action potential (GO:0086011)2.73829776
60interferon-gamma-mediated signaling pathway (GO:0060333)2.72900119
61cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.72173353
62positive regulation of lamellipodium assembly (GO:0010592)2.70968167
63regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.70842067
64cellular anion homeostasis (GO:0030002)2.70461819
65regulation of fibrinolysis (GO:0051917)2.69210725
66positive regulation of fatty acid beta-oxidation (GO:0032000)2.66228919
67antigen receptor-mediated signaling pathway (GO:0050851)2.66117803
68positive regulation of fatty acid oxidation (GO:0046321)2.65861144
69glomerular basement membrane development (GO:0032836)2.65331431
70germ cell migration (GO:0008354)2.64176362
71T cell migration (GO:0072678)2.61042692
72detection of molecule of bacterial origin (GO:0032490)2.60662295
73lymphangiogenesis (GO:0001946)2.60637549
74natural killer cell differentiation (GO:0001779)2.59972145
75growth hormone receptor signaling pathway (GO:0060396)2.56238631
76B cell proliferation (GO:0042100)2.55346975
77interferon-gamma production (GO:0032609)2.55165379
78neutrophil activation (GO:0042119)2.54763072
79regulation of hippo signaling (GO:0035330)2.53858024
80endocardial cushion development (GO:0003197)2.53794257
81response to laminar fluid shear stress (GO:0034616)2.53317486
82modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51928934
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51928934
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.51928934
85modulation by symbiont of host immune response (GO:0052553)2.51928934
86positive regulation by symbiont of host defense response (GO:0052509)2.51928934
87modulation by symbiont of host defense response (GO:0052031)2.51928934
88cell adhesion mediated by integrin (GO:0033627)2.50804490
89surfactant homeostasis (GO:0043129)2.50571157
90negative regulation of B cell proliferation (GO:0030889)2.50462635
91positive regulation of interleukin-2 production (GO:0032743)2.50223325
92nephron epithelium morphogenesis (GO:0072088)2.49967402
93nephron tubule morphogenesis (GO:0072078)2.49967402
94regulation of interferon-beta biosynthetic process (GO:0045357)2.49957487
95regulation of B cell proliferation (GO:0030888)2.49772798
96positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49252957
97positive regulation of alpha-beta T cell proliferation (GO:0046641)2.47993500
98positive regulation of macrophage differentiation (GO:0045651)2.47612794
99response to muramyl dipeptide (GO:0032495)2.47502886
100leukocyte migration involved in inflammatory response (GO:0002523)2.47255762
101diacylglycerol metabolic process (GO:0046339)2.46370995
102regulation of cell proliferation involved in kidney development (GO:1901722)2.45385602
103positive regulation of B cell differentiation (GO:0045579)2.44376738
104negative regulation of Rho protein signal transduction (GO:0035024)2.44310669
105neutrophil activation involved in immune response (GO:0002283)2.43937355
106positive regulation of extracellular matrix organization (GO:1903055)2.43753484
107Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43389181
108very-low-density lipoprotein particle assembly (GO:0034379)2.42018130
109chemical homeostasis within a tissue (GO:0048875)2.41138551
110angiogenesis involved in wound healing (GO:0060055)2.39943890
111intestinal absorption (GO:0050892)2.39932803
112regulation of response to interferon-gamma (GO:0060330)2.39012195
113positive regulation of lamellipodium organization (GO:1902745)2.38638573
114low-density lipoprotein particle remodeling (GO:0034374)2.38043480
115regulation of extracellular matrix disassembly (GO:0010715)2.37910867
116plasma lipoprotein particle assembly (GO:0034377)2.36685535
117positive regulation of endothelial cell differentiation (GO:0045603)2.35720678
118regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.34832624
119regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.34527612
120regulation of macrophage cytokine production (GO:0010935)2.34352381
121lung lobe morphogenesis (GO:0060463)2.33786812
122regulation of endothelial cell differentiation (GO:0045601)2.33351246
123microglial cell activation (GO:0001774)2.33237893
124T cell receptor signaling pathway (GO:0050852)2.33156316
125negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.32702290
126regulation of T cell receptor signaling pathway (GO:0050856)2.32388204
127myeloid dendritic cell activation (GO:0001773)2.31860216
128positive regulation of interferon-alpha production (GO:0032727)2.31748046
129regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.31593951
130positive regulation of isotype switching (GO:0045830)2.30375930
131glomerular visceral epithelial cell development (GO:0072015)2.30257707
132regulation of interferon-alpha production (GO:0032647)2.30071977
133positive regulation of endothelial cell apoptotic process (GO:2000353)2.29684279
134transepithelial transport (GO:0070633)2.29666039
135apoptotic cell clearance (GO:0043277)2.29486733
136immune response-activating cell surface receptor signaling pathway (GO:0002429)2.29429811
137patterning of blood vessels (GO:0001569)2.29177607
138Notch signaling involved in heart development (GO:0061314)2.27336984
139granulocyte activation (GO:0036230)2.26927883
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.26027673
141natural killer cell activation (GO:0030101)2.25839502
142tyrosine phosphorylation of STAT protein (GO:0007260)2.25515339
143positive regulation of B cell proliferation (GO:0030890)2.23400542
144positive regulation of astrocyte differentiation (GO:0048711)2.23331882
145myeloid dendritic cell differentiation (GO:0043011)2.23038265
146response to type I interferon (GO:0034340)2.22936292
147lipoprotein metabolic process (GO:0042157)2.20912428
148regulation of regulatory T cell differentiation (GO:0045589)2.20074960
149regulation of non-canonical Wnt signaling pathway (GO:2000050)2.18439787
150positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.17938695
151flavonoid metabolic process (GO:0009812)2.16633842
152high-density lipoprotein particle remodeling (GO:0034375)2.15382891
153phosphate ion homeostasis (GO:0055062)2.14419957
154trivalent inorganic anion homeostasis (GO:0072506)2.14419957
155SMAD protein signal transduction (GO:0060395)2.13983348
156negative regulation of metanephros development (GO:0072217)2.13780659
157interkinetic nuclear migration (GO:0022027)2.13767788
158regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.13369755
159blood coagulation, intrinsic pathway (GO:0007597)2.13347641
160regulation of cholesterol homeostasis (GO:2000188)2.12896678
161positive regulation of male gonad development (GO:2000020)2.12601864
162positive regulation of metanephros development (GO:0072216)2.11499772
163regulation of humoral immune response (GO:0002920)2.10479812
164plasma lipoprotein particle remodeling (GO:0034369)2.10276523
165protein-lipid complex remodeling (GO:0034368)2.10276523
166macromolecular complex remodeling (GO:0034367)2.10276523
167lung vasculature development (GO:0060426)2.09633930
168activated T cell proliferation (GO:0050798)2.09080576
169regulation of metanephros development (GO:0072215)2.08996107
170negative regulation of leukocyte chemotaxis (GO:0002689)2.08629444
171interferon-gamma secretion (GO:0072643)2.08624809
172maintenance of gastrointestinal epithelium (GO:0030277)2.08423838
173phospholipid homeostasis (GO:0055091)2.08084580
174reverse cholesterol transport (GO:0043691)2.07182062
175negative regulation of fatty acid transport (GO:2000192)2.05654291
176positive regulation of blood coagulation (GO:0030194)2.04908413
177positive regulation of hemostasis (GO:1900048)2.04908413
178regulation of cholesterol storage (GO:0010885)2.04162704
179regulation of alkaline phosphatase activity (GO:0010692)2.02807692
180mesonephros development (GO:0001823)2.02184040
181purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.01462139
1823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.01462139
183positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.01418309
184low-density lipoprotein particle clearance (GO:0034383)2.00951859
185plasma lipoprotein particle organization (GO:0071827)2.00771221
186T cell mediated immunity (GO:0002456)1.99861470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.04032773
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.87781753
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.29528928
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.72675838
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.53726198
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.89550798
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.86738480
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.82737465
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.74097149
10* RUNX_20019798_ChIP-Seq_JUKART_Human2.70335249
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64224232
12MYC_22102868_ChIP-Seq_BL_Human2.61183912
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.53087887
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.48699477
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.43570684
16* MYB_26560356_Chip-Seq_TH2_Human2.41688126
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.41531163
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.37331626
19MAF_26560356_Chip-Seq_TH1_Human2.36054793
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.31065637
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.30750852
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29997072
23* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21469439
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.19394476
25STAT4_19710469_ChIP-ChIP_TH1__Mouse2.10217893
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08464045
27VDR_21846776_ChIP-Seq_THP-1_Human2.06433932
28MYB_26560356_Chip-Seq_TH1_Human2.05928298
29UTX_26944678_Chip-Seq_JUKART_Human2.01085222
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98400260
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98369653
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94249581
33* CLOCK_20551151_ChIP-Seq_293T_Human1.92584364
34VDR_24763502_ChIP-Seq_THP-1_Human1.85520611
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84774730
36TCF7_22412390_ChIP-Seq_EML_Mouse1.83987069
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.82478286
38* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80538781
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79882834
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.79096760
41* LXR_22158963_ChIP-Seq_LIVER_Mouse1.79026751
42* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.77706956
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73621748
44* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71803812
45* FOXA2_19822575_ChIP-Seq_HepG2_Human1.70338557
46* AHR_22903824_ChIP-Seq_MCF-7_Human1.67929319
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.66996019
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64653618
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.62939399
50KDM2B_26808549_Chip-Seq_DND41_Human1.61969933
51* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57663188
52* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.56034601
53* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55375978
54SCL_19346495_ChIP-Seq_HPC-7_Human1.55259886
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.54932947
56* ARNT_22903824_ChIP-Seq_MCF-7_Human1.54865444
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53930625
58TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53811975
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.53094240
60SPI1_23127762_ChIP-Seq_K562_Human1.49553025
61GATA3_27048872_Chip-Seq_THYMUS_Human1.49431739
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.47682222
63CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45755011
64TP53_16413492_ChIP-PET_HCT116_Human1.44579983
65VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43365354
66KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42899309
67Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42007180
68* RUNX1_22412390_ChIP-Seq_EML_Mouse1.41096329
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40909200
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.39802911
71ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.39290866
72SPI1_23547873_ChIP-Seq_NB4_Human1.38704843
73SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36688573
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36688573
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33893550
76* CDX2_20551321_ChIP-Seq_CACO-2_Human1.31978133
77VDR_24787735_ChIP-Seq_THP-1_Human1.31972316
78RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31386181
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31023341
80AR_21572438_ChIP-Seq_LNCaP_Human1.30815813
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29703886
82* PIAS1_25552417_ChIP-Seq_VCAP_Human1.29385051
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29016458
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.28866848
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27967604
86MAF_26560356_Chip-Seq_TH2_Human1.27829612
87* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27323743
88* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27314202
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.26352493
90CJUN_26792858_Chip-Seq_BT549_Human1.26289025
91EZH2_22144423_ChIP-Seq_EOC_Human1.26072459
92ESR1_21235772_ChIP-Seq_MCF-7_Human1.24609130
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.24496025
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23782756
95ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23769833
96FOXM1_23109430_ChIP-Seq_U2OS_Human1.23391148
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.21992423
98PU_27001747_Chip-Seq_BMDM_Mouse1.21404101
99* RXR_22108803_ChIP-Seq_LS180_Human1.20572837
100GATA1_22025678_ChIP-Seq_K562_Human1.18531122
101RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17816004
102PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15227720
103GBX2_23144817_ChIP-Seq_PC3_Human1.14873949
104E2F7_22180533_ChIP-Seq_HELA_Human1.13805443
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.13157701
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11593659
107BRD4_25478319_ChIP-Seq_HGPS_Human1.11061381
108ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10972361
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10391228
110GATA4_25053715_ChIP-Seq_YYC3_Human1.10356917
111DROSHA_22980978_ChIP-Seq_HELA_Human1.09998753
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09571438
113FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08859425
114* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07775751
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07095701
116PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06431718
117SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05729918
118* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05503752
119SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04241165
120ESR1_20079471_ChIP-ChIP_T-47D_Human1.04069846
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03495809
122STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02543819
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01973326
124WT1_19549856_ChIP-ChIP_CCG9911_Human1.01448957
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.99667382
126* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98736679
127FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98656272
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97592635
129ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97524510
130GATA2_19941826_ChIP-Seq_K562_Human0.97015950
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96017081
132NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95972375
133NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95972375
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95910422
135NCOR1_26117541_ChIP-Seq_K562_Human0.95775741
136BCAT_22108803_ChIP-Seq_LS180_Human0.95699545
137EED_16625203_ChIP-ChIP_MESCs_Mouse0.95095282
138EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94637652
139RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94637652
140FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94596573
141ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93397705
142TBX20_22328084_ChIP-Seq_HEART_Mouse0.93308310
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.93308310
144* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92800955
145RUNX1_27514584_Chip-Seq_MCF-7_Human0.92469870
146JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92389097
147* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92297804
148SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.92167372
149UBF1/2_26484160_Chip-Seq_HMECs_Human0.92040089
150GATA1_19941826_ChIP-Seq_K562_Human0.91983898
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91859336
152AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91048909
153* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90655164
154* SOX2_20726797_ChIP-Seq_SW620_Human0.89893623
155* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89850620
156SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.89649341
157TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89450927
158STAT3_23295773_ChIP-Seq_U87_Human0.88073270
159ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88056366
160* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87555376
161SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86494916
162SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85372032
163* HNF4A_19822575_ChIP-Seq_HepG2_Human0.84878868
164JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83933184
165* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83671584
166CDX2_22108803_ChIP-Seq_LS180_Human0.83484146
167FLI1_27457419_Chip-Seq_LIVER_Mouse0.83461813
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82911975
169CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82815687
170FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81076128
171SUZ12_27294783_Chip-Seq_NPCs_Mouse0.80940432

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.20611071
2MP0010368_abnormal_lymphatic_system2.88198610
3MP0008438_abnormal_cutaneous_collagen2.83851879
4MP0001835_abnormal_antigen_presentation2.79993049
5MP0003303_peritoneal_inflammation2.73782685
6MP0005360_urolithiasis2.66274139
7MP0001879_abnormal_lymphatic_vessel2.58990391
8MP0001790_abnormal_immune_system2.56224267
9MP0005387_immune_system_phenotype2.56224267
10MP0000685_abnormal_immune_system2.52020970
11MP0001800_abnormal_humoral_immune2.46417842
12MP0003724_increased_susceptibility_to2.41521523
13MP0002166_altered_tumor_susceptibility2.38572017
14MP0005671_abnormal_response_to2.28942774
15MP0003763_abnormal_thymus_physiology2.27550544
16MP0003195_calcinosis2.16281765
17* MP0002452_abnormal_antigen_presenting2.14598465
18MP0009785_altered_susceptibility_to2.11653608
19MP0005377_hearing/vestibular/ear_phenot2.08003192
20MP0003878_abnormal_ear_physiology2.08003192
21MP0001958_emphysema2.07803790
22MP0005000_abnormal_immune_tolerance2.06923902
23MP0006054_spinal_hemorrhage2.05965508
24MP0003436_decreased_susceptibility_to2.02798930
25MP0005085_abnormal_gallbladder_physiolo2.02326045
26MP0003252_abnormal_bile_duct2.01677684
27MP0003279_aneurysm1.97996848
28* MP0002420_abnormal_adaptive_immunity1.95590685
29* MP0001819_abnormal_immune_cell1.92339340
30MP0003705_abnormal_hypodermis_morpholog1.91577788
31MP0001873_stomach_inflammation1.91379128
32MP0005409_darkened_coat_color1.90384637
33MP0002139_abnormal_hepatobiliary_system1.89737937
34MP0010329_abnormal_lipoprotein_level1.89098422
35MP0002723_abnormal_immune_serum1.88343194
36MP0002006_tumorigenesis1.87725183
37MP0003566_abnormal_cell_adhesion1.83265609
38MP0005275_abnormal_skin_tensile1.79992567
39MP0002933_joint_inflammation1.77773226
40MP0010352_gastrointestinal_tract_polyps1.77289204
41MP0009278_abnormal_bone_marrow1.77187867
42MP0002405_respiratory_system_inflammati1.77075979
43MP0005365_abnormal_bile_salt1.72469936
44MP0002398_abnormal_bone_marrow1.70876217
45MP0005025_abnormal_response_to1.70480473
46MP0010155_abnormal_intestine_physiology1.68059316
47MP0004947_skin_inflammation1.67759912
48MP0002419_abnormal_innate_immunity1.66453903
49MP0003091_abnormal_cell_migration1.64519496
50MP0000569_abnormal_digit_pigmentation1.58947704
51MP0004808_abnormal_hematopoietic_stem1.57510650
52* MP0000716_abnormal_immune_system1.56249874
53MP0005670_abnormal_white_adipose1.52041267
54MP0001666_abnormal_nutrient_absorption1.49974433
55MP0001485_abnormal_pinna_reflex1.49571721
56MP0002148_abnormal_hypersensitivity_rea1.49017294
57MP0005023_abnormal_wound_healing1.49014564
58MP0005076_abnormal_cell_differentiation1.48431430
59MP0001533_abnormal_skeleton_physiology1.45357638
60MP0004272_abnormal_basement_membrane1.43928899
61MP0004510_myositis1.43224196
62MP0001853_heart_inflammation1.42038639
63MP0002396_abnormal_hematopoietic_system1.40625182
64MP0003448_altered_tumor_morphology1.40597222
65MP0002928_abnormal_bile_duct1.38602724
66MP0000465_gastrointestinal_hemorrhage1.37031283
67* MP0000689_abnormal_spleen_morphology1.35052945
68MP0003828_pulmonary_edema1.35046084
69MP0010234_abnormal_vibrissa_follicle1.32569782
70MP0003011_delayed_dark_adaptation1.32353510
71MP0002132_abnormal_respiratory_system1.31494002
72MP0001845_abnormal_inflammatory_respons1.30570327
73MP0003122_maternal_imprinting1.30511220
74MP0009384_cardiac_valve_regurgitation1.30040558
75* MP0002722_abnormal_immune_system1.29450667
76MP0000858_altered_metastatic_potential1.28657732
77* MP0002429_abnormal_blood_cell1.26258522
78MP0004885_abnormal_endolymph1.24104288
79MP0009333_abnormal_splenocyte_physiolog1.22641626
80MP0000703_abnormal_thymus_morphology1.22165410
81MP0000767_abnormal_smooth_muscle1.22139942
82MP0003183_abnormal_peptide_metabolism1.20871512
83MP0003045_fibrosis1.20861876
84MP0002998_abnormal_bone_remodeling1.20632058
85MP0004130_abnormal_muscle_cell1.19828100
86MP0005397_hematopoietic_system_phenotyp1.19458654
87MP0001545_abnormal_hematopoietic_system1.19458654
88MP0002138_abnormal_hepatobiliary_system1.18961788
89MP0003866_abnormal_defecation1.18750103
90MP0005503_abnormal_tendon_morphology1.16533546
91MP0002876_abnormal_thyroid_physiology1.12026299
92MP0006138_congestive_heart_failure1.08707156
93MP0001851_eye_inflammation1.08350764
94MP0002060_abnormal_skin_morphology1.05264742
95MP0000013_abnormal_adipose_tissue1.05226500
96MP0005595_abnormal_vascular_smooth1.04837282
97MP0002277_abnormal_respiratory_mucosa1.03927112
98MP0005084_abnormal_gallbladder_morpholo1.03327719
99MP0001756_abnormal_urination1.02465679
100MP0003879_abnormal_hair_cell1.01676399
101MP0000343_altered_response_to1.01654352
102MP0003950_abnormal_plasma_membrane0.99288046
103MP0004782_abnormal_surfactant_physiolog0.99174277
104MP0003453_abnormal_keratinocyte_physiol0.98574726
105MP0005464_abnormal_platelet_physiology0.97945784
106MP0004019_abnormal_vitamin_homeostasis0.97618133
107MP0002133_abnormal_respiratory_system0.97551543
108MP0005388_respiratory_system_phenotype0.97551543
109MP0002089_abnormal_postnatal_growth/wei0.96093783
110MP0005390_skeleton_phenotype0.95843061
111MP0000249_abnormal_blood_vessel0.95227206
112MP0002909_abnormal_adrenal_gland0.92006932
113MP0002009_preneoplasia0.91797858
114MP0004484_altered_response_of0.90333738
115MP0006082_CNS_inflammation0.88969995
116MP0000490_abnormal_crypts_of0.87541974
117MP0005167_abnormal_blood-brain_barrier0.86265326
118MP0009115_abnormal_fat_cell0.85011971
119MP0008875_abnormal_xenobiotic_pharmacok0.84399503
120MP0009840_abnormal_foam_cell0.84129506
121MP0004381_abnormal_hair_follicle0.83901659
122MP0002118_abnormal_lipid_homeostasis0.82737324
123MP0003136_yellow_coat_color0.82445828
124MP0001765_abnormal_ion_homeostasis0.82301998
125MP0003942_abnormal_urinary_system0.81459282
126MP0003795_abnormal_bone_structure0.80845800
127MP0002135_abnormal_kidney_morphology0.80766987
128MP0002282_abnormal_trachea_morphology0.79902447
129MP0002925_abnormal_cardiovascular_devel0.78769824
130MP0009643_abnormal_urine_homeostasis0.78667958
131MP0003868_abnormal_feces_composition0.78628204
132MP0004883_abnormal_blood_vessel0.78578158
133MP0002128_abnormal_blood_circulation0.78235419
134MP0005164_abnormal_response_to0.77531959
135MP0002136_abnormal_kidney_physiology0.76943537
136MP0008961_abnormal_basal_metabolism0.76583522
137MP0000566_synostosis0.75566455
138MP0005408_hypopigmentation0.75431618
139MP0000733_abnormal_muscle_development0.75308576
140MP0000534_abnormal_ureter_morphology0.74636961
141MP0001501_abnormal_sleep_pattern0.74280483
142MP0009764_decreased_sensitivity_to0.73676199
143MP0002168_other_aberrant_phenotype0.73352697
144MP0005166_decreased_susceptibility_to0.71150029
145MP0001243_abnormal_dermal_layer0.70849393
146MP0008469_abnormal_protein_level0.69845914
147MP0003943_abnormal_hepatobiliary_system0.68234399
148MP0001614_abnormal_blood_vessel0.67216382
149MP0002254_reproductive_system_inflammat0.66407493
150MP0005623_abnormal_meninges_morphology0.65626470
151MP0002295_abnormal_pulmonary_circulatio0.65461543
152MP0001663_abnormal_digestive_system0.64797593
153MP0002019_abnormal_tumor_incidence0.64734324

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.47008953
2Abnormality of the nasal septum (HP:0000419)4.17633753
3Agammaglobulinemia (HP:0004432)3.95148539
4Recurrent bronchitis (HP:0002837)3.91070772
5Cellulitis (HP:0100658)3.68330402
6Aortic aneurysm (HP:0004942)3.58468346
7Eczematoid dermatitis (HP:0000976)3.38823187
8Optic neuritis (HP:0100653)3.31049327
9Retrobulbar optic neuritis (HP:0100654)3.31049327
10Interstitial pulmonary disease (HP:0006530)3.28986760
11Hematochezia (HP:0002573)3.24296456
12Aortic dissection (HP:0002647)3.17078433
13Recurrent abscess formation (HP:0002722)3.13494581
14Gastrointestinal stroma tumor (HP:0100723)3.11864922
15Joint hemorrhage (HP:0005261)3.02951627
16Spontaneous hematomas (HP:0007420)3.02073369
17Verrucae (HP:0200043)3.01707628
18Papilloma (HP:0012740)3.01707628
19Recurrent viral infections (HP:0004429)3.01442086
20Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.98069771
21Glomerulonephritis (HP:0000099)2.98007303
22Recurrent fungal infections (HP:0002841)2.97545633
23Pigmentary retinal degeneration (HP:0001146)2.96569090
24Cerebral aneurysm (HP:0004944)2.95912104
25Emphysema (HP:0002097)2.95452381
26Small epiphyses (HP:0010585)2.95277143
27Colitis (HP:0002583)2.88394057
28Protrusio acetabuli (HP:0003179)2.87908988
29IgM deficiency (HP:0002850)2.87197943
30Abnormality of T cell number (HP:0011839)2.87051525
31T lymphocytopenia (HP:0005403)2.82327616
32Autoimmune thrombocytopenia (HP:0001973)2.81527739
33Lymphopenia (HP:0001888)2.80954363
34Chronic otitis media (HP:0000389)2.74610464
35Recurrent gram-negative bacterial infections (HP:0005420)2.74087830
36Abnormality of cells of the lymphoid lineage (HP:0012140)2.73340729
37Inflammation of the large intestine (HP:0002037)2.73277091
38Meningitis (HP:0001287)2.71702079
39Abnormality of the nasal mucosa (HP:0000433)2.70589628
40Gastrointestinal infarctions (HP:0005244)2.70241169
41Dilatation of the ascending aorta (HP:0005111)2.68027718
42Complement deficiency (HP:0004431)2.67131807
43Vascular tortuosity (HP:0004948)2.63282565
44Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.59729371
45Gastrointestinal inflammation (HP:0004386)2.59258849
46Myositis (HP:0100614)2.55494479
47Vasculitis (HP:0002633)2.54229511
48Osteomyelitis (HP:0002754)2.53698429
49Arthropathy (HP:0003040)2.52729847
50Decreased circulating renin level (HP:0003351)2.51382903
51IgA deficiency (HP:0002720)2.50794331
52Genetic anticipation (HP:0003743)2.47546703
53Premature rupture of membranes (HP:0001788)2.43851564
54Chronic sinusitis (HP:0011109)2.42653937
55Vascular calcification (HP:0004934)2.42495859
56Keratoconjunctivitis sicca (HP:0001097)2.41454483
57Recurrent sinusitis (HP:0011108)2.40433527
58Abnormality of the frontal sinuses (HP:0002687)2.38663178
59Abnormal delayed hypersensitivity skin test (HP:0002963)2.38219539
60Recurrent bacterial skin infections (HP:0005406)2.37900648
61Elevated erythrocyte sedimentation rate (HP:0003565)2.37667467
62Increased density of long bones (HP:0006392)2.37446325
63Abnormality of B cell number (HP:0010975)2.37134568
64B lymphocytopenia (HP:0010976)2.37134568
65Potter facies (HP:0002009)2.36809840
66Facial shape deformation (HP:0011334)2.36809840
67Osteolytic defects of the phalanges of the hand (HP:0009771)2.36658169
68Osteolytic defects of the hand bones (HP:0009699)2.36658169
69Arterial tortuosity (HP:0005116)2.35864390
70Epiphyseal dysplasia (HP:0002656)2.35651567
71Keratoconjunctivitis (HP:0001096)2.34920250
72Thyroiditis (HP:0100646)2.34711403
73Subacute progressive viral hepatitis (HP:0006572)2.33882377
74Spondylolisthesis (HP:0003302)2.33720035
75Prolonged partial thromboplastin time (HP:0003645)2.33068197
76Pustule (HP:0200039)2.32627505
77Panhypogammaglobulinemia (HP:0003139)2.32555393
78Ulnar bowing (HP:0003031)2.29773602
79Mediastinal lymphadenopathy (HP:0100721)2.28895089
80Abnormality of T cells (HP:0002843)2.28800785
81Short femoral neck (HP:0100864)2.28256452
82Periodontitis (HP:0000704)2.26473691
83Abnormality of the peritoneum (HP:0002585)2.26435356
84Nephritis (HP:0000123)2.24564100
85Hemorrhage of the eye (HP:0011885)2.24522628
86Mitral valve prolapse (HP:0001634)2.24155434
87Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22608713
88Short 4th metacarpal (HP:0010044)2.22608713
89Chronic mucocutaneous candidiasis (HP:0002728)2.22241739
90Recurrent cutaneous fungal infections (HP:0011370)2.22241739
91Abnormality of the fingertips (HP:0001211)2.22042246
92Cardiovascular calcification (HP:0011915)2.21743120
93Clumsiness (HP:0002312)2.21507934
94Bronchitis (HP:0012387)2.21222592
95Mitral stenosis (HP:0001718)2.20825952
96Broad metatarsal (HP:0001783)2.17731915
97Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16090539
98Stomach cancer (HP:0012126)2.15828608
99Eosinophilia (HP:0001880)2.15772102
100Systemic lupus erythematosus (HP:0002725)2.15586050
101Menorrhagia (HP:0000132)2.14976439
102Nasal polyposis (HP:0100582)2.14446688
103Abnormality of the wing of the ilium (HP:0011867)2.14269967
104Vitreoretinal degeneration (HP:0000655)2.13430421
105Shallow orbits (HP:0000586)2.12056184
106Abnormality of the proximal phalanges of the hand (HP:0009834)2.11531930
107Abnormality of the common coagulation pathway (HP:0010990)2.11530306
108Restrictive lung disease (HP:0002091)2.11405678
109Xanthomatosis (HP:0000991)2.10950440
110Pulmonary embolism (HP:0002204)2.09807475
111Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.08528079
112Atrophic scars (HP:0001075)2.08078864
113Portal hypertension (HP:0001409)2.07609352
114Metabolic alkalosis (HP:0200114)2.06077754
115Joint swelling (HP:0001386)2.05845580
116Epidermoid cyst (HP:0200040)2.05505391
117Striae distensae (HP:0001065)2.04180564
118Recurrent pneumonia (HP:0006532)2.03097485
119Viral hepatitis (HP:0006562)2.02129843
120Increased corneal curvature (HP:0100692)2.00989464
121Keratoconus (HP:0000563)2.00989464
122Bronchomalacia (HP:0002780)2.00856667
123Recurrent lower respiratory tract infections (HP:0002783)1.99967857
124Sepsis (HP:0100806)1.99367723
125Gingival bleeding (HP:0000225)1.98789336
126Aplasia/hypoplasia of the femur (HP:0005613)1.98689198
127True hermaphroditism (HP:0010459)1.98647876
128Absent frontal sinuses (HP:0002688)1.97204420
129Arterial thrombosis (HP:0004420)1.95741406
130Gingivitis (HP:0000230)1.95429493
131Sex reversal (HP:0012245)1.95254170
132Abnormal sex determination (HP:0012244)1.95254170
133Orchitis (HP:0100796)1.95100702
134Skin ulcer (HP:0200042)1.95082700
135Abnormality of the pleura (HP:0002103)1.95026926
136Abnormality of complement system (HP:0005339)1.94380455
137Persistence of primary teeth (HP:0006335)1.93954682
138Esophageal varix (HP:0002040)1.93478804
139Adactyly (HP:0009776)1.93059063
140Bicuspid aortic valve (HP:0001647)1.92585714
141Hemoptysis (HP:0002105)1.92296124
142Periauricular skin pits (HP:0100277)1.92267186
143Preauricular pit (HP:0004467)1.92267186
144Toxemia of pregnancy (HP:0100603)1.91798398
145Pulmonary infiltrates (HP:0002113)1.91464473
146IgG deficiency (HP:0004315)1.90858104
147Polycythemia (HP:0001901)1.90686494
148Peritonitis (HP:0002586)1.90486029
149Hypoplasia of the ulna (HP:0003022)1.88752634
150Ankle contracture (HP:0006466)1.88738349
151Stomatitis (HP:0010280)1.88722305
152Gonadal dysgenesis (HP:0000133)1.87305167
153Aplasia/Hypoplasia of the fibula (HP:0006492)1.87126239
154Mitral regurgitation (HP:0001653)1.86468677
155Recurrent skin infections (HP:0001581)1.86422742
156Osteomalacia (HP:0002749)1.86353208
157Fibular hypoplasia (HP:0003038)1.85450170
158Hemiplegia (HP:0002301)1.84854642
159Abnormality of T cell physiology (HP:0011840)1.82933030
160Camptodactyly of toe (HP:0001836)1.81879187
161Leukocytosis (HP:0001974)1.81747673
162Abnormality of the middle phalanges of the toes (HP:0010183)1.81437492
163Testicular neoplasm (HP:0010788)1.81274704
164Aneurysm (HP:0002617)1.81109050
165Abnormality of the hepatic vasculature (HP:0006707)1.79989157
166Autoimmune hemolytic anemia (HP:0001890)1.79221166
167Chest pain (HP:0100749)1.78675171
168Myocardial infarction (HP:0001658)1.78271143
169Combined immunodeficiency (HP:0005387)1.78045321
170Short hallux (HP:0010109)1.77055504
171Focal segmental glomerulosclerosis (HP:0000097)1.76385734
172Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.71268682
173Conical tooth (HP:0000698)1.68978322
174Congenital sensorineural hearing impairment (HP:0008527)1.68956765
175Xerostomia (HP:0000217)1.68612636
176Morphological abnormality of the middle ear (HP:0008609)1.68113143
177Genu varum (HP:0002970)1.67530459
178Congenital, generalized hypertrichosis (HP:0004540)1.66463124
179Supernumerary bones of the axial skeleton (HP:0009144)1.65588044
180Anomalous pulmonary venous return (HP:0010772)1.65350067
181Abnormality of the renal cortex (HP:0011035)1.64447198
182Segmental peripheral demyelination/remyelination (HP:0003481)1.64105887

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.53984857
2STK102.84405848
3MAP3K102.60625626
4TGFBR22.41183969
5ERN12.41061938
6TXK2.26465702
7TAOK32.22836467
8JAK32.18935850
9LRRK22.16245665
10FGFR42.14599797
11TIE12.12360441
12TRIB32.04230075
13FGFR32.01601798
14MAPK152.00714780
15JAK11.99955077
16PIK3CA1.95903645
17TBK11.94615552
18TYK21.90443231
19ZAP701.81253753
20KDR1.81215739
21ITK1.78377499
22GRK61.77752124
23MAP3K141.76612078
24TTN1.76137287
25SGK21.71651858
26IKBKE1.69455748
27EPHB11.63641362
28IRAK11.61725257
29EEF2K1.61046398
30CSK1.60528529
31WNK41.58020521
32EPHA31.57373096
33MST41.54252814
34TEC1.53260247
35RIPK11.53154999
36AKT31.44430212
37SGK2231.44287347
38SGK4941.44287347
39BTK1.41490514
40PKN21.41059113
41WNK11.41001747
42RPS6KA41.32987378
43STK391.32185295
44SGK31.27419132
45HCK1.25310748
46KIT1.24438871
47PTK61.17398585
48TGFBR11.15973201
49NLK1.14630629
50BLK1.10348963
51CSF1R1.10295089
52MARK31.10111654
53NEK91.09967176
54ERBB21.09901481
55FRK1.08316468
56CHUK1.07955285
57TRPM71.06956803
58STK38L1.06415164
59LCK1.04607886
60IKBKB1.00842541
61SYK1.00480899
62PRKCH1.00097884
63FER1.00043585
64SIK10.98722461
65CLK10.98326956
66BMPR1B0.95257055
67EPHB20.93354806
68PIM10.92826836
69PTK2B0.91331525
70IRAK40.90304029
71ACVR1B0.90110933
72MARK20.89980336
73CDK120.88713167
74TYRO30.87701521
75PRKAA20.85786270
76DMPK0.85577526
77FGFR20.85255189
78TNK20.85196465
79CDK90.84732058
80PAK40.84347117
81CDK60.83611065
82MYLK0.83566630
83RPS6KA20.82888767
84MAP2K30.82632773
85TLK10.82488470
86ADRBK20.81330782
87STK380.80469292
88CDC42BPA0.79099388
89MAP3K30.78971282
90RPS6KA60.77299860
91NUAK10.75922997
92MAPK70.75801120
93PDGFRB0.74812489
94MAP3K20.73318373
95RET0.72705782
96MAP3K10.72364930
97LATS10.71540651
98PDGFRA0.70959997
99CAMK1D0.70279869
100JAK20.70057102
101SIK20.70022897
102INSRR0.69922656
103MELK0.69091770
104PDPK10.68655610
105MATK0.67661744
106PRKCQ0.66607283
107LYN0.66431488
108PINK10.66216117
109EPHA20.65813775
110FGFR10.65199505
111OXSR10.64797701
112IRAK30.64137448
113RIPK40.64049672
114STK30.63206603
115PAK30.62318435
116PDK10.61133307
117STK40.60963845
118PRKD10.60289792
119RPS6KC10.59453936
120RPS6KL10.59453936
121MAP2K20.58500167
122SGK10.56601575
123INSR0.56334396
124MAP3K120.51177671
125YES10.50831938
126PRKG20.50617418
127PRKCZ0.50493813
128DYRK1B0.50344121
129ICK0.50230997
130FES0.49215258
131PRKD20.48323381
132ABL10.48292269
133HIPK20.48288986
134GRK10.48078229
135CAMK1G0.46928770
136MAP3K80.46732543
137MAP3K130.46019291
138EGFR0.45486591
139PTK20.44229400
140MAPKAPK20.43617816
141CDK40.43170187
142FGR0.42842936
143PAK20.40674563
144STK240.40595217
145FYN0.39002832
146ILK0.38927515
147MAP3K70.38693182
148BMX0.38655301

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.39116316
2Complement and coagulation cascades_Homo sapiens_hsa046102.95627285
3B cell receptor signaling pathway_Homo sapiens_hsa046622.59868695
4Leishmaniasis_Homo sapiens_hsa051402.39023866
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.21660479
6Leukocyte transendothelial migration_Homo sapiens_hsa046702.12587168
7Osteoclast differentiation_Homo sapiens_hsa043802.04445348
8Vitamin digestion and absorption_Homo sapiens_hsa049772.04322614
9Hematopoietic cell lineage_Homo sapiens_hsa046402.03240481
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.00192005
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.99554897
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.95706722
13T cell receptor signaling pathway_Homo sapiens_hsa046601.87685514
14Viral myocarditis_Homo sapiens_hsa054161.80435782
15Measles_Homo sapiens_hsa051621.79879763
16Toxoplasmosis_Homo sapiens_hsa051451.79772851
17Malaria_Homo sapiens_hsa051441.69889353
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67234459
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.64943040
20Antigen processing and presentation_Homo sapiens_hsa046121.57581896
21Fat digestion and absorption_Homo sapiens_hsa049751.56120882
22TNF signaling pathway_Homo sapiens_hsa046681.55607604
23Focal adhesion_Homo sapiens_hsa045101.52465602
24Small cell lung cancer_Homo sapiens_hsa052221.51595240
25Chronic myeloid leukemia_Homo sapiens_hsa052201.46672322
26Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46003955
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.44724707
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.44350031
29Pancreatic cancer_Homo sapiens_hsa052121.42859454
30Shigellosis_Homo sapiens_hsa051311.42584303
31ABC transporters_Homo sapiens_hsa020101.41220219
32Adherens junction_Homo sapiens_hsa045201.40939159
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.40593261
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39655061
35ECM-receptor interaction_Homo sapiens_hsa045121.38179205
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36203907
37PPAR signaling pathway_Homo sapiens_hsa033201.35554332
38Chemokine signaling pathway_Homo sapiens_hsa040621.32083932
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31712689
40Allograft rejection_Homo sapiens_hsa053301.31565790
41Platelet activation_Homo sapiens_hsa046111.29155702
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.26790118
43Fatty acid biosynthesis_Homo sapiens_hsa000611.26394092
44Graft-versus-host disease_Homo sapiens_hsa053321.26011413
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25704347
46Histidine metabolism_Homo sapiens_hsa003401.25357189
47Hepatitis B_Homo sapiens_hsa051611.24715552
48Proteoglycans in cancer_Homo sapiens_hsa052051.24281853
49NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23789353
50Tuberculosis_Homo sapiens_hsa051521.22051924
51Nitrogen metabolism_Homo sapiens_hsa009101.20823895
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20289637
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19638218
54Apoptosis_Homo sapiens_hsa042101.18103320
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15928508
56Herpes simplex infection_Homo sapiens_hsa051681.15926612
57Acute myeloid leukemia_Homo sapiens_hsa052211.15835706
58Pertussis_Homo sapiens_hsa051331.12949378
59Salmonella infection_Homo sapiens_hsa051321.12602877
60HTLV-I infection_Homo sapiens_hsa051661.12338509
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12222482
62Influenza A_Homo sapiens_hsa051641.12184791
63Chemical carcinogenesis_Homo sapiens_hsa052041.11819096
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11241601
65Bile secretion_Homo sapiens_hsa049761.10791446
66Amoebiasis_Homo sapiens_hsa051461.10041410
67MicroRNAs in cancer_Homo sapiens_hsa052061.07568512
68Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04469265
69Linoleic acid metabolism_Homo sapiens_hsa005911.03994407
70Steroid hormone biosynthesis_Homo sapiens_hsa001401.03089319
71Starch and sucrose metabolism_Homo sapiens_hsa005001.01481451
72Autoimmune thyroid disease_Homo sapiens_hsa053201.00020656
73Notch signaling pathway_Homo sapiens_hsa043300.97675659
74Retinol metabolism_Homo sapiens_hsa008300.97073098
75Legionellosis_Homo sapiens_hsa051340.96387459
76Hepatitis C_Homo sapiens_hsa051600.95751723
77Glycerolipid metabolism_Homo sapiens_hsa005610.94355984
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93857852
79Viral carcinogenesis_Homo sapiens_hsa052030.91553057
80Tryptophan metabolism_Homo sapiens_hsa003800.86291368
81Colorectal cancer_Homo sapiens_hsa052100.85395395
82Prostate cancer_Homo sapiens_hsa052150.84535503
83Type I diabetes mellitus_Homo sapiens_hsa049400.84405052
84VEGF signaling pathway_Homo sapiens_hsa043700.84168450
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83215366
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83116562
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82831737
88Pathways in cancer_Homo sapiens_hsa052000.82527977
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.82448094
90Insulin resistance_Homo sapiens_hsa049310.79612125
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79610313
92Mineral absorption_Homo sapiens_hsa049780.79571807
93TGF-beta signaling pathway_Homo sapiens_hsa043500.78437132
94Non-small cell lung cancer_Homo sapiens_hsa052230.77223307
95FoxO signaling pathway_Homo sapiens_hsa040680.76816576
96Prolactin signaling pathway_Homo sapiens_hsa049170.76477353
97Dorso-ventral axis formation_Homo sapiens_hsa043200.75871511
98Rap1 signaling pathway_Homo sapiens_hsa040150.73932844
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.73758492
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.72612063
101Staphylococcus aureus infection_Homo sapiens_hsa051500.71484509
102Circadian rhythm_Homo sapiens_hsa047100.70652120
103Ether lipid metabolism_Homo sapiens_hsa005650.70500694
104Renal cell carcinoma_Homo sapiens_hsa052110.69478290
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68333462
106p53 signaling pathway_Homo sapiens_hsa041150.67766602
107Epstein-Barr virus infection_Homo sapiens_hsa051690.66964100
108HIF-1 signaling pathway_Homo sapiens_hsa040660.66942411
109African trypanosomiasis_Homo sapiens_hsa051430.66203922
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.66063405
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65346450
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65331930
113Bladder cancer_Homo sapiens_hsa052190.64778473
114Endometrial cancer_Homo sapiens_hsa052130.62999947
115Renin secretion_Homo sapiens_hsa049240.61573334
116Rheumatoid arthritis_Homo sapiens_hsa053230.60531189
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60325350
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.59614174
119Ovarian steroidogenesis_Homo sapiens_hsa049130.58667223
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58107468
121Endocytosis_Homo sapiens_hsa041440.56875333
122Arachidonic acid metabolism_Homo sapiens_hsa005900.56218187
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55798186
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53917031
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53748037
126Asthma_Homo sapiens_hsa053100.53518610
127Glioma_Homo sapiens_hsa052140.53227505
128Choline metabolism in cancer_Homo sapiens_hsa052310.52069299
129Fatty acid degradation_Homo sapiens_hsa000710.51797323
130Protein digestion and absorption_Homo sapiens_hsa049740.50445643
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.49767686
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49766464
133Hedgehog signaling pathway_Homo sapiens_hsa043400.49678880
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49547584
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.49384718
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48444143
137mTOR signaling pathway_Homo sapiens_hsa041500.48317738
138Thyroid hormone synthesis_Homo sapiens_hsa049180.48188877
139Basal cell carcinoma_Homo sapiens_hsa052170.48130654
140Axon guidance_Homo sapiens_hsa043600.46787319
141Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46597404
142MAPK signaling pathway_Homo sapiens_hsa040100.45522114
143Caffeine metabolism_Homo sapiens_hsa002320.44996215
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44826974
145Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44209829
146Renin-angiotensin system_Homo sapiens_hsa046140.43996740
147Dilated cardiomyopathy_Homo sapiens_hsa054140.43869777
148Hippo signaling pathway_Homo sapiens_hsa043900.42024960
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.40083540

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