NEFH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* neurofilament cytoskeleton organization (GO:0060052)9.28315840
2neuronal action potential propagation (GO:0019227)6.72110280
3negative regulation of dendrite morphogenesis (GO:0050774)6.41448126
4cerebellar granule cell differentiation (GO:0021707)5.86895212
5cell migration in hindbrain (GO:0021535)5.78046384
6synaptic vesicle maturation (GO:0016188)5.61903819
7neuromuscular process controlling posture (GO:0050884)5.36902768
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.24520418
9detection of temperature stimulus (GO:0016048)5.23519636
10axon cargo transport (GO:0008088)5.01549861
11cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.00257034
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.73563451
13proline transport (GO:0015824)4.63410520
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.62496476
15sodium ion export (GO:0071436)4.61707573
16regulation of synaptic vesicle exocytosis (GO:2000300)4.60948161
17calcium-mediated signaling using intracellular calcium source (GO:0035584)4.60785722
18glutamate secretion (GO:0014047)4.60431353
19synaptic vesicle exocytosis (GO:0016079)4.59047191
20membrane depolarization during action potential (GO:0086010)4.57517942
21detection of temperature stimulus involved in sensory perception of pain (GO:0050965)4.46951343
22detection of temperature stimulus involved in sensory perception (GO:0050961)4.46951343
23cellular potassium ion homeostasis (GO:0030007)4.44625857
24positive regulation of synapse maturation (GO:0090129)4.42804137
25gamma-aminobutyric acid signaling pathway (GO:0007214)4.40393122
26cell communication by electrical coupling (GO:0010644)4.39250282
27negative regulation of dendrite development (GO:2000171)4.38893295
28positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.31706389
29peripheral nervous system neuron development (GO:0048935)4.31199526
30cerebellar Purkinje cell differentiation (GO:0021702)4.30659854
31synaptic transmission, glutamatergic (GO:0035249)4.29027718
32neuronal ion channel clustering (GO:0045161)4.23626632
33neuron-neuron synaptic transmission (GO:0007270)4.21638595
34establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.18764424
35mitochondrion transport along microtubule (GO:0047497)4.18764424
36negative regulation of microtubule polymerization (GO:0031115)4.18296282
37regulation of translational termination (GO:0006449)4.16117609
38neurotransmitter secretion (GO:0007269)4.13459406
39establishment of mitochondrion localization (GO:0051654)4.13251059
40positive regulation of potassium ion transmembrane transport (GO:1901381)4.08638668
41regulation of synaptic vesicle transport (GO:1902803)4.06703660
42L-amino acid import (GO:0043092)4.04683911
43glycine transport (GO:0015816)4.02146571
44neuronal action potential (GO:0019228)4.01892592
45cerebellar Purkinje cell layer development (GO:0021680)4.01577067
46glutamate receptor signaling pathway (GO:0007215)4.00373822
47regulation of neurotransmitter secretion (GO:0046928)4.00150407
48innervation (GO:0060384)4.00120581
49synaptic vesicle endocytosis (GO:0048488)3.99267834
50positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.99222724
51regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.97641598
52cell communication involved in cardiac conduction (GO:0086065)3.95639930
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93011319
54regulation of synaptic plasticity (GO:0048167)3.92582925
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91777317
56membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.90261874
57* intermediate filament organization (GO:0045109)3.90200752
58membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.85131035
59positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.84196173
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.81540304
61cell differentiation in hindbrain (GO:0021533)3.80541308
62activation of protein kinase A activity (GO:0034199)3.79709933
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.79636970
64long-term memory (GO:0007616)3.78294894
65regulation of ARF protein signal transduction (GO:0032012)3.73757858
66amino acid import (GO:0043090)3.73346388
67organelle transport along microtubule (GO:0072384)3.72011114
68positive regulation of potassium ion transport (GO:0043268)3.71801948
69negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.68197015
70positive regulation of dendritic spine morphogenesis (GO:0061003)3.66784623
71regulation of postsynaptic membrane potential (GO:0060078)3.66473745
72regulation of neurotransmitter transport (GO:0051588)3.63205770
73regulation of sensory perception (GO:0051931)3.61136409
74regulation of sensory perception of pain (GO:0051930)3.61136409
75locomotory exploration behavior (GO:0035641)3.61024029
76regulation of glutamate receptor signaling pathway (GO:1900449)3.59546470
77layer formation in cerebral cortex (GO:0021819)3.59048752
78positive regulation of dendritic spine development (GO:0060999)3.58528605
79positive regulation of membrane potential (GO:0045838)3.58295536
80vesicle transport along microtubule (GO:0047496)3.57561838
81regulation of sodium ion transmembrane transporter activity (GO:2000649)3.53965925
82membrane repolarization (GO:0086009)3.53220339
83negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52815710
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.51892443
85membrane repolarization during action potential (GO:0086011)3.50684173
86negative regulation of potassium ion transmembrane transport (GO:1901380)3.48921261
87neuromuscular process controlling balance (GO:0050885)3.48888124
88regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.48416137
89axon ensheathment in central nervous system (GO:0032291)3.48036741
90central nervous system myelination (GO:0022010)3.48036741
91exploration behavior (GO:0035640)3.46825139
92regulation of vesicle fusion (GO:0031338)3.45244891
93response to acidic pH (GO:0010447)3.43710963
94potassium ion homeostasis (GO:0055075)3.43535132
95prepulse inhibition (GO:0060134)3.42689833
96regulation of voltage-gated calcium channel activity (GO:1901385)3.39387365
97neurotransmitter transport (GO:0006836)3.38784565
98protein localization to synapse (GO:0035418)3.33936428
99membrane depolarization (GO:0051899)3.33051079
100regulation of synapse maturation (GO:0090128)3.32707419
101regulation of synapse structural plasticity (GO:0051823)3.29824551
102regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.29074413
103plasma membrane repair (GO:0001778)3.28570146
104inositol phosphate catabolic process (GO:0071545)3.28453186
105synaptic vesicle docking involved in exocytosis (GO:0016081)3.26599328
106anterograde axon cargo transport (GO:0008089)3.26159318
107positive regulation of neurotransmitter transport (GO:0051590)3.25049780
108regulation of neuronal synaptic plasticity (GO:0048168)3.24110135
109transmission of nerve impulse (GO:0019226)3.23952463
110neuromuscular process (GO:0050905)3.23341614
111regulation of calcium ion-dependent exocytosis (GO:0017158)3.21032197
112potassium ion import (GO:0010107)3.20920534
113regulation of membrane repolarization (GO:0060306)3.19418169
114regulation of synaptic transmission (GO:0050804)3.19033173
115behavioral response to cocaine (GO:0048148)3.18946310
116cytoskeletal anchoring at plasma membrane (GO:0007016)3.18129168
117acidic amino acid transport (GO:0015800)3.18059668
118positive regulation of axon extension (GO:0045773)3.17170165
119microtubule-based transport (GO:0010970)3.16357383
120long-term synaptic potentiation (GO:0060291)3.14698334
121neurotransmitter-gated ion channel clustering (GO:0072578)3.14168088
122positive regulation of neurotransmitter secretion (GO:0001956)3.13588233
123regulation of dendritic spine morphogenesis (GO:0061001)3.12011614
124negative regulation of inclusion body assembly (GO:0090084)3.10128021
125postsynaptic membrane organization (GO:0001941)3.09888330
126G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09201187
127neuron cell-cell adhesion (GO:0007158)3.08908791
128synaptic transmission (GO:0007268)3.08508533
129neuromuscular synaptic transmission (GO:0007274)3.08032206
130cytoskeleton-dependent intracellular transport (GO:0030705)3.07456374
131establishment of synaptic vesicle localization (GO:0097480)3.06867055
132synaptic vesicle transport (GO:0048489)3.06867055
133regulation of neurotransmitter levels (GO:0001505)3.05931093
134* intermediate filament cytoskeleton organization (GO:0045104)3.05762784
135regulation of NFAT protein import into nucleus (GO:0051532)3.04420581
136cellular sodium ion homeostasis (GO:0006883)3.04382039
137positive regulation of sodium ion transport (GO:0010765)3.03354941
138vocalization behavior (GO:0071625)3.02336748
139* intermediate filament-based process (GO:0045103)3.01910520
140sodium ion transmembrane transport (GO:0035725)3.00550727
141short-term memory (GO:0007614)3.00459188
142positive regulation of axonogenesis (GO:0050772)3.00135627
143adult walking behavior (GO:0007628)2.99649610
144regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.99350329
145mating behavior (GO:0007617)2.99000658
146gamma-aminobutyric acid transport (GO:0015812)2.98577227
147regulation of sodium ion transmembrane transport (GO:1902305)2.97574858
148calcium ion-dependent exocytosis (GO:0017156)2.96644923
149C4-dicarboxylate transport (GO:0015740)2.96466264
150regulation of exocytosis (GO:0017157)2.96381125
151regulation of potassium ion transmembrane transport (GO:1901379)2.96330620
152enteric nervous system development (GO:0048484)2.94349155
153negative regulation of calcium ion transport into cytosol (GO:0010523)2.94032139
154regulation of calcium ion transmembrane transporter activity (GO:1901019)2.93180894
155regulation of calcium ion transmembrane transport (GO:1903169)2.93180894
156suckling behavior (GO:0001967)2.90540916
157cellular potassium ion transport (GO:0071804)2.89909636
158potassium ion transmembrane transport (GO:0071805)2.89909636
159action potential (GO:0001508)2.89829019
160axon regeneration (GO:0031103)2.87496829
161negative regulation of cation channel activity (GO:2001258)2.87485254

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.62283422
2* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18377223
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.17200900
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11581260
5GBX2_23144817_ChIP-Seq_PC3_Human2.99901329
6JARID2_20075857_ChIP-Seq_MESCs_Mouse2.94219440
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.92149600
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90815994
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90815994
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.71873767
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64671360
12REST_18959480_ChIP-ChIP_MESCs_Mouse2.57086378
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.56472241
14* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.46794190
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39113329
16TAF15_26573619_Chip-Seq_HEK293_Human2.34308964
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.28749462
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.20438613
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.20029851
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.15449298
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.05049038
22DROSHA_22980978_ChIP-Seq_HELA_Human2.04848241
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04000826
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.01651617
25AR_21572438_ChIP-Seq_LNCaP_Human1.94799125
26IGF1R_20145208_ChIP-Seq_DFB_Human1.90832506
27NR3C1_23031785_ChIP-Seq_PC12_Mouse1.90796658
28SMAD4_21799915_ChIP-Seq_A2780_Human1.74309238
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.71824081
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71696619
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69920171
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.65693510
33* EED_16625203_ChIP-ChIP_MESCs_Mouse1.65365043
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.65229494
35* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.64727099
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64677094
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.62431474
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60301575
39KDM2B_26808549_Chip-Seq_K562_Human1.56694890
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53133829
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44729586
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41222381
43ZNF274_21170338_ChIP-Seq_K562_Hela1.40832326
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37567774
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37423484
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36299597
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33491732
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.31523482
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31150542
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30796705
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29986331
52STAT3_23295773_ChIP-Seq_U87_Human1.28593025
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25828975
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24708234
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.24689869
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.23878441
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19501999
58CTCF_27219007_Chip-Seq_Bcells_Human1.18775568
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17968561
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.17877253
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17652054
62LXR_22292898_ChIP-Seq_THP-1_Human1.17581784
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16603727
64AR_25329375_ChIP-Seq_VCAP_Human1.16445121
65* TET1_21490601_ChIP-Seq_MESCs_Mouse1.15863025
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15728160
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15465030
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14703296
69P300_19829295_ChIP-Seq_ESCs_Human1.14622840
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14502886
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13221736
72SMC4_20622854_ChIP-Seq_HELA_Human1.12217572
73* AR_19668381_ChIP-Seq_PC3_Human1.12095823
74SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12018833
75* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10663834
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.10539581
77AHR_22903824_ChIP-Seq_MCF-7_Human1.09821127
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09713264
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07763673
80ZNF263_19887448_ChIP-Seq_K562_Human1.06417283
81* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05367227
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.03959898
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03150931
84MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02655785
85ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.01944525
86RNF2_27304074_Chip-Seq_NSC_Mouse1.01126885
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00588724
88SMAD4_21741376_ChIP-Seq_EPCs_Human1.00449952
89WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98102908
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97224818
91KLF4_19829295_ChIP-Seq_ESCs_Human0.97182663
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.96580886
93* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96516721
94OCT4_19829295_ChIP-Seq_ESCs_Human0.96187614
95KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95915870
96RUNX1_26923725_Chip-Seq_HPCs_Mouse0.94999140
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94829740
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.93419437
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.93070735
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91015952
101GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.90924319
102CREB1_26743006_Chip-Seq_LNCaP_Human0.90769819
103KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90616217
104PRDM14_20953172_ChIP-Seq_ESCs_Human0.89928011
105MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89906417
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89231735
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88987704
108CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88409201
109TCF4_23295773_ChIP-Seq_U87_Human0.88218847
110FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87881646
111P68_20966046_ChIP-Seq_HELA_Human0.87774831
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.87427695
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87331225
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87128121
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85383931
116BCAT_22108803_ChIP-Seq_LS180_Human0.85043653
117* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.84680889
118CBX2_27304074_Chip-Seq_ESCs_Mouse0.83742373
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.82846916
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81411256
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81411256
122CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81403447
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.81096499
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.80557603
125PIAS1_25552417_ChIP-Seq_VCAP_Human0.79864380
126* RING1B_27294783_Chip-Seq_NPCs_Mouse0.79542740
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79261501
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78360427
129KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.77550769
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77174720

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception5.67523494
2MP0004270_analgesia4.54608636
3MP0001968_abnormal_touch/_nociception4.50000227
4MP0002736_abnormal_nociception_after4.25441100
5MP0004859_abnormal_synaptic_plasticity3.99770733
6MP0004858_abnormal_nervous_system3.85305266
7MP0003880_abnormal_central_pattern3.75626589
8MP0002734_abnormal_mechanical_nocicepti3.46228686
9MP0006276_abnormal_autonomic_nervous3.46189148
10MP0002733_abnormal_thermal_nociception3.38532757
11MP0009046_muscle_twitch3.34281118
12MP0003635_abnormal_synaptic_transmissio3.01520164
13MP0004147_increased_porphyrin_level2.97418769
14MP0001970_abnormal_pain_threshold2.87094976
15* MP0002272_abnormal_nervous_system2.71762064
16MP0001348_abnormal_lacrimal_gland2.54219834
17MP0003329_amyloid_beta_deposits2.46717699
18MP0002067_abnormal_sensory_capabilities2.46552860
19MP0002064_seizures2.41370227
20MP0001986_abnormal_taste_sensitivity2.40701142
21MP0009745_abnormal_behavioral_response2.27135522
22MP0002184_abnormal_innervation2.18290158
23MP0002063_abnormal_learning/memory/cond2.12771990
24MP0008569_lethality_at_weaning2.08044731
25MP0001486_abnormal_startle_reflex2.00190288
26* MP0000955_abnormal_spinal_cord1.95020752
27MP0003787_abnormal_imprinting1.92457282
28MP0004142_abnormal_muscle_tone1.89085411
29MP0005423_abnormal_somatic_nervous1.88860575
30* MP0004811_abnormal_neuron_physiology1.85917530
31MP0002572_abnormal_emotion/affect_behav1.76417606
32MP0010386_abnormal_urinary_bladder1.60899845
33MP0002909_abnormal_adrenal_gland1.56971323
34MP0002751_abnormal_autonomic_nervous1.54050384
35MP0003633_abnormal_nervous_system1.49508593
36* MP0002229_neurodegeneration1.47025097
37MP0001501_abnormal_sleep_pattern1.44494514
38MP0001440_abnormal_grooming_behavior1.44371712
39* MP0002882_abnormal_neuron_morphology1.39980977
40MP0004924_abnormal_behavior1.37398891
41MP0005386_behavior/neurological_phenoty1.37398891
42MP0003123_paternal_imprinting1.32792106
43* MP0002066_abnormal_motor_capabilities/c1.32548630
44MP0000604_amyloidosis1.31552800
45MP0000751_myopathy1.30864210
46MP0000778_abnormal_nervous_system1.29464379
47MP0004145_abnormal_muscle_electrophysio1.28416610
48MP0005083_abnormal_biliary_tract1.24670801
49MP0001299_abnormal_eye_distance/1.23706263
50MP0000920_abnormal_myelination1.22994347
51MP0008877_abnormal_DNA_methylation1.22289089
52MP0003634_abnormal_glial_cell1.22060640
53MP0003631_nervous_system_phenotype1.21245602
54MP0005623_abnormal_meninges_morphology1.21090299
55MP0003879_abnormal_hair_cell1.13721311
56MP0002557_abnormal_social/conspecific_i1.13179688
57MP0001188_hyperpigmentation1.09290581
58MP0003183_abnormal_peptide_metabolism1.08693467
59MP0002638_abnormal_pupillary_reflex1.07151174
60MP0001177_atelectasis1.06323607
61MP0009780_abnormal_chondrocyte_physiolo1.01551780
62MP0003011_delayed_dark_adaptation1.01550372
63MP0000747_muscle_weakness1.01031848
64MP0005551_abnormal_eye_electrophysiolog0.99306998
65* MP0002752_abnormal_somatic_nervous0.97805341
66MP0001963_abnormal_hearing_physiology0.91443814
67MP0003698_abnormal_male_reproductive0.91203175
68MP0004885_abnormal_endolymph0.89692572
69MP0001485_abnormal_pinna_reflex0.89132850
70MP0001984_abnormal_olfaction0.87958419
71MP0003632_abnormal_nervous_system0.80257834
72MP0000749_muscle_degeneration0.79378176
73MP0001849_ear_inflammation0.75497384
74MP0003656_abnormal_erythrocyte_physiolo0.74903317
75MP0001270_distended_abdomen0.73322505
76MP0002161_abnormal_fertility/fecundity0.72630927
77MP0000534_abnormal_ureter_morphology0.72459580
78MP0004085_abnormal_heartbeat0.71931627
79MP0008874_decreased_physiological_sensi0.71704429
80MP0005409_darkened_coat_color0.71096325
81MP0008872_abnormal_physiological_respon0.66978531
82MP0003283_abnormal_digestive_organ0.66632296
83MP0002152_abnormal_brain_morphology0.66490088
84MP0003122_maternal_imprinting0.66064761
85MP0005535_abnormal_body_temperature0.65436469
86MP0005167_abnormal_blood-brain_barrier0.63731279
87MP0002837_dystrophic_cardiac_calcinosis0.63043765
88MP0003646_muscle_fatigue0.62876760
89MP0001765_abnormal_ion_homeostasis0.62210890
90MP0005670_abnormal_white_adipose0.61985541
91MP0004742_abnormal_vestibular_system0.61963238
92MP0008260_abnormal_autophagy0.61140889
93MP0004036_abnormal_muscle_relaxation0.60869680
94MP0004510_myositis0.60599536
95MP0000372_irregular_coat_pigmentation0.58061367
96MP0001905_abnormal_dopamine_level0.57618706
97MP0001664_abnormal_digestion0.57332901
98MP0000566_synostosis0.57314561
99MP0003045_fibrosis0.56867914
100MP0002089_abnormal_postnatal_growth/wei0.56537682
101MP0003137_abnormal_impulse_conducting0.56507055
102MP0002090_abnormal_vision0.55786835
103MP0009379_abnormal_foot_pigmentation0.55408357
104MP0005410_abnormal_fertilization0.55064312
105MP0003172_abnormal_lysosome_physiology0.54713314
106MP0003690_abnormal_glial_cell0.54538345
107MP0001929_abnormal_gametogenesis0.54386782
108MP0000569_abnormal_digit_pigmentation0.54158912
109MP0001529_abnormal_vocalization0.53647236
110MP0003121_genomic_imprinting0.52912646
111MP0005645_abnormal_hypothalamus_physiol0.52747188
112MP0010768_mortality/aging0.52530661
113MP0004215_abnormal_myocardial_fiber0.52518757
114MP0006035_abnormal_mitochondrial_morpho0.52423393
115MP0005646_abnormal_pituitary_gland0.51961687
116MP0002822_catalepsy0.51645753
117MP0002082_postnatal_lethality0.51541689
118MP0010770_preweaning_lethality0.51541689
119MP0003956_abnormal_body_size0.51166627
120* MP0003861_abnormal_nervous_system0.51142335
121MP0001943_abnormal_respiration0.51014994
122MP0002069_abnormal_eating/drinking_beha0.50813675
123MP0002234_abnormal_pharynx_morphology0.50765669
124MP0002873_normal_phenotype0.50345390
125MP0005394_taste/olfaction_phenotype0.49468640
126MP0001502_abnormal_circadian_rhythm0.48333210
127MP0010769_abnormal_survival0.47813733
128MP0004883_abnormal_blood_vessel0.47267587
129MP0004484_altered_response_of0.47034276
130MP0002269_muscular_atrophy0.44956425

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.05544083
2Myokymia (HP:0002411)7.77582892
3Action tremor (HP:0002345)6.15406433
4Segmental peripheral demyelination/remyelination (HP:0003481)5.73580922
5Supranuclear gaze palsy (HP:0000605)5.12680962
6Focal motor seizures (HP:0011153)5.06469564
7Insidious onset (HP:0003587)4.81720597
8Termporal pattern (HP:0011008)4.81720597
9Atonic seizures (HP:0010819)4.78220068
10Pheochromocytoma (HP:0002666)4.68720005
11Febrile seizures (HP:0002373)4.63453823
12Limb dystonia (HP:0002451)4.28088260
13Hammertoe (HP:0001765)4.27374053
14Neuroendocrine neoplasm (HP:0100634)4.21947188
15Foot dorsiflexor weakness (HP:0009027)4.05970836
16Focal seizures (HP:0007359)4.02569935
17Steppage gait (HP:0003376)3.98315848
18Ventricular fibrillation (HP:0001663)3.88567601
19Progressive cerebellar ataxia (HP:0002073)3.85238956
20Abnormality of binocular vision (HP:0011514)3.83413550
21Diplopia (HP:0000651)3.83413550
22Ankle clonus (HP:0011448)3.80636089
23Abnormality of the foot musculature (HP:0001436)3.67284867
24Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.64881029
25Dysmetric saccades (HP:0000641)3.64399864
26Onion bulb formation (HP:0003383)3.56701871
27Visual hallucinations (HP:0002367)3.53016945
28Urinary urgency (HP:0000012)3.45472482
29Absence seizures (HP:0002121)3.39318038
30Decreased motor nerve conduction velocity (HP:0003431)3.34372536
31Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.31385441
32Hypercortisolism (HP:0001578)3.27523041
33Neurofibrillary tangles (HP:0002185)3.26825422
34Cerebral hypomyelination (HP:0006808)3.24749951
35Spastic gait (HP:0002064)3.21583628
36Status epilepticus (HP:0002133)3.20143818
37Focal dystonia (HP:0004373)3.18253113
38Truncal ataxia (HP:0002078)3.17346417
39Distal sensory impairment (HP:0002936)3.16261830
40Generalized tonic-clonic seizures (HP:0002069)3.02639101
41Abnormality of pain sensation (HP:0010832)3.01844766
42Impaired pain sensation (HP:0007328)3.01844766
43Neoplasm of the peripheral nervous system (HP:0100007)2.95867574
44Scanning speech (HP:0002168)2.94129243
45Dialeptic seizures (HP:0011146)2.93315891
46Peripheral hypomyelination (HP:0007182)2.91613620
47Tetraplegia (HP:0002445)2.87531693
48Mutism (HP:0002300)2.83139176
49Failure to thrive in infancy (HP:0001531)2.81526736
50Obstructive sleep apnea (HP:0002870)2.81505316
51Cerebral inclusion bodies (HP:0100314)2.80380772
52Slow saccadic eye movements (HP:0000514)2.80084807
53Urinary bladder sphincter dysfunction (HP:0002839)2.76055641
54Epileptic encephalopathy (HP:0200134)2.74091795
55Impaired vibration sensation in the lower limbs (HP:0002166)2.72270512
56Abnormality of ocular smooth pursuit (HP:0000617)2.72055517
57Abnormality of the vocal cords (HP:0008777)2.69972741
58Abnormality of the corticospinal tract (HP:0002492)2.65840412
59Craniofacial dystonia (HP:0012179)2.61174431
60Rigidity (HP:0002063)2.59493586
61Muscle stiffness (HP:0003552)2.52948854
62Epileptiform EEG discharges (HP:0011182)2.51597100
63Papilledema (HP:0001085)2.50817716
64Neoplasm of the heart (HP:0100544)2.50437800
65Depression (HP:0000716)2.50108858
66Neuronal loss in central nervous system (HP:0002529)2.46153934
67Abnormality of the lower motor neuron (HP:0002366)2.42908417
68Akinesia (HP:0002304)2.38122021
69Lower limb muscle weakness (HP:0007340)2.35263265
70Broad-based gait (HP:0002136)2.34483009
71Dysautonomia (HP:0002459)2.32235510
72Paraplegia (HP:0010550)2.31840659
73Dysmetria (HP:0001310)2.30904516
74Insomnia (HP:0100785)2.28061632
75Amblyopia (HP:0000646)2.27782311
76Gaze-evoked nystagmus (HP:0000640)2.26001066
77Myotonia (HP:0002486)2.24254074
78Poor eye contact (HP:0000817)2.24192107
79Postural tremor (HP:0002174)2.24010320
80Hemiparesis (HP:0001269)2.23542501
81Abnormal eating behavior (HP:0100738)2.23181443
82Annular pancreas (HP:0001734)2.21477915
83Spastic paraplegia (HP:0001258)2.19788463
84Sleep apnea (HP:0010535)2.18058523
85Abnormality of the musculature of the hand (HP:0001421)2.18003950
86EEG with generalized epileptiform discharges (HP:0011198)2.17259381
87Postural instability (HP:0002172)2.16701299
88Hyporeflexia of lower limbs (HP:0002600)2.16686576
89Gait ataxia (HP:0002066)2.15846072
90Anxiety (HP:0000739)2.13336995
91Horizontal nystagmus (HP:0000666)2.13329512
92CNS hypomyelination (HP:0003429)2.12588620
93Hypoplasia of the brainstem (HP:0002365)2.10738833
94Aplasia/Hypoplasia of the brainstem (HP:0007362)2.10738833
95Distal arthrogryposis (HP:0005684)2.09277738
96Resting tremor (HP:0002322)2.08534547
97Hypoventilation (HP:0002791)2.07294058
98Limb ataxia (HP:0002070)2.06057667
99Fetal akinesia sequence (HP:0001989)2.05357031
100Bundle branch block (HP:0011710)2.03314783
101Progressive inability to walk (HP:0002505)2.02424073
102Choreoathetosis (HP:0001266)2.01396582
103Clonus (HP:0002169)2.01070789
104Hypothermia (HP:0002045)2.00702626
105Peripheral demyelination (HP:0011096)2.00531799
106Spastic tetraparesis (HP:0001285)2.00157018
107Delusions (HP:0000746)1.99520317
108Hemiplegia (HP:0002301)1.99022240
109Stereotypic behavior (HP:0000733)1.98708916
110Menstrual irregularities (HP:0000858)1.97249803
111Rapidly progressive (HP:0003678)1.97055404
112Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96503272
113Bradykinesia (HP:0002067)1.95967001
114Areflexia of lower limbs (HP:0002522)1.95532187
115Cerebral hemorrhage (HP:0001342)1.95128849
116Pes cavus (HP:0001761)1.94890193
117Bradycardia (HP:0001662)1.93699942
118Dysdiadochokinesis (HP:0002075)1.93325246
119Degeneration of the lateral corticospinal tracts (HP:0002314)1.92554071
120Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92554071
121Incomplete penetrance (HP:0003829)1.91989415
122Impaired proprioception (HP:0010831)1.87369995
123Hypsarrhythmia (HP:0002521)1.85771463
124Apathy (HP:0000741)1.85451623
125Aplasia involving bones of the extremities (HP:0009825)1.83541351
126Aplasia involving bones of the upper limbs (HP:0009823)1.83541351
127Aplasia of the phalanges of the hand (HP:0009802)1.83541351
128Diminished motivation (HP:0000745)1.83059591
129Abnormality of saccadic eye movements (HP:0000570)1.82199557
130Amelogenesis imperfecta (HP:0000705)1.81014940
131Slow progression (HP:0003677)1.80303645
132Abnormal social behavior (HP:0012433)1.79538112
133Impaired social interactions (HP:0000735)1.79538112
134Torticollis (HP:0000473)1.78139225
135Impaired vibratory sensation (HP:0002495)1.77278427
136Impaired smooth pursuit (HP:0007772)1.76916461
137Increased circulating renin level (HP:0000848)1.75799768
138Dysarthria (HP:0001260)1.75338947
139Abnormality of calcium-phosphate metabolism (HP:0100530)1.75279531
140Lower limb asymmetry (HP:0100559)1.75229268
141Thyroid carcinoma (HP:0002890)1.73037405
142Intention tremor (HP:0002080)1.72777497
143Prolonged QT interval (HP:0001657)1.72128118
144Morphological abnormality of the pyramidal tract (HP:0002062)1.72010473
145Abnormal EKG (HP:0003115)1.66828258
146Heart block (HP:0012722)1.66609758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.77004223
2MINK14.60245552
3LMTK24.49094965
4EPHA44.33223387
5MAP3K93.51520896
6MAP3K122.98370039
7WNK12.90232781
8MAP3K42.81614529
9KSR22.74504163
10LATS22.62462975
11NTRK12.62239719
12MAP2K42.40902284
13LIMK12.31438997
14MAP2K72.25244843
15TESK12.12094016
16SCYL22.09575060
17PHKG12.04647772
18PHKG22.04647772
19STK391.90753867
20PAK61.88544032
21MAP3K21.88130899
22WNK41.80136615
23RET1.76665972
24CAMKK11.56686038
25MAPKAPK31.54257353
26CAMK11.50684692
27STK381.43240652
28CASK1.39685001
29NEK11.36919434
30RIPK11.34367118
31BRAF1.33607502
32AKT31.32264484
33MAP3K131.25138620
34MYLK1.24363687
35MAPK131.21739913
36TNK21.21107578
37MARK11.20780624
38CAMK2B1.17431103
39NEK61.17328768
40MAP3K111.16936486
41GRK51.14316623
42CDK51.10331222
43CAMK1G1.07758275
44SGK2231.05662966
45SGK4941.05662966
46CAMKK21.04298802
47PINK11.03336893
48PRKCG1.03006764
49CDK191.02848918
50MARK21.02089558
51PRPF4B0.98464461
52TYRO30.98324431
53MAP3K10.95434060
54ARAF0.95009524
55MAPKAPK50.94424329
56MAP2K10.93018655
57UHMK10.91127359
58FER0.89297044
59PNCK0.85501340
60SGK10.84741249
61RIPK40.83772697
62RPS6KA20.83066695
63MATK0.83056935
64CAMK1D0.81181485
65PRKD30.79345961
66PRKCH0.78935566
67SGK20.78127713
68PDPK10.75989959
69PRKG20.74309456
70PDK10.73721661
71DMPK0.73386943
72DYRK1A0.69051357
73SIK20.67539298
74SGK30.67174469
75NEK90.67101308
76DAPK30.66752624
77ROCK20.66107777
78GRK70.66092149
79CDC42BPA0.65032248
80ALK0.63770399
81PAK20.63282500
82TAOK10.61063769
83ADRBK10.60993174
84CSNK1E0.59870498
85CAMK2G0.59442526
86EEF2K0.57637846
87MAPK120.57094620
88BRSK10.57025780
89CAMK40.56665080
90KSR10.55991400
91CDK140.55455454
92ROCK10.54104563
93MAPK100.52554995
94FES0.51528445
95EPHA30.50346596
96CAMK2A0.47252214
97CDK180.45633301
98PRKG10.45531574
99CSNK1G20.42827224
100MUSK0.42534813
101MOS0.42190328
102CDK150.41778571
103MAP2K60.41020407
104FYN0.40578311
105PKN10.40219915
106PAK30.40211511
107CSNK1G30.40013961
108PLK20.39000221
109PRKCA0.38902836
110PDK40.38681111
111PDK30.38681111
112PRKACB0.38619630
113CSNK1A10.38403319
114TESK20.37521246
115NTRK20.37413247
116CDK11A0.34808554
117STK110.34228933
118PRKCZ0.33951989
119SIK30.33081933
120RPS6KA30.33039107
121PRKACA0.30810423
122PRKACG0.27594520
123DAPK20.27230901
124AURKA0.27225118
125OXSR10.27222247
126MAPK80.26615224
127PRKCE0.26411878
128FGFR30.26291153
129PRKCB0.24110796
130DAPK10.18920047
131CAMK2D0.18871856
132RAF10.18785137

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.80405083
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.46205297
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.36536952
4Olfactory transduction_Homo sapiens_hsa047402.62343542
5Long-term potentiation_Homo sapiens_hsa047202.13749368
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09163904
7* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.08556594
8Nicotine addiction_Homo sapiens_hsa050332.02341597
9Dopaminergic synapse_Homo sapiens_hsa047282.01320022
10Circadian entrainment_Homo sapiens_hsa047131.88424387
11Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88035758
12Taste transduction_Homo sapiens_hsa047421.84426998
13Gastric acid secretion_Homo sapiens_hsa049711.84260237
14Dorso-ventral axis formation_Homo sapiens_hsa043201.81112680
15Insulin secretion_Homo sapiens_hsa049111.81047376
16Salivary secretion_Homo sapiens_hsa049701.75410412
17Cholinergic synapse_Homo sapiens_hsa047251.74804695
18Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.71734468
19GABAergic synapse_Homo sapiens_hsa047271.70143701
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.68701426
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.60859264
22Glutamatergic synapse_Homo sapiens_hsa047241.57576073
23Amphetamine addiction_Homo sapiens_hsa050311.54201710
24GnRH signaling pathway_Homo sapiens_hsa049121.51872116
25Fatty acid biosynthesis_Homo sapiens_hsa000611.46452071
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32374083
27Oocyte meiosis_Homo sapiens_hsa041141.32123705
28Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.30416144
29Morphine addiction_Homo sapiens_hsa050321.30248275
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.29424292
31Gap junction_Homo sapiens_hsa045401.26207673
32Cardiac muscle contraction_Homo sapiens_hsa042601.24170822
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22957340
34Glioma_Homo sapiens_hsa052141.21886701
35Renin secretion_Homo sapiens_hsa049241.20489787
36Oxytocin signaling pathway_Homo sapiens_hsa049211.19133988
37Collecting duct acid secretion_Homo sapiens_hsa049661.18223520
38Serotonergic synapse_Homo sapiens_hsa047261.17698912
39ErbB signaling pathway_Homo sapiens_hsa040121.17067969
40Long-term depression_Homo sapiens_hsa047301.16489100
41Vitamin B6 metabolism_Homo sapiens_hsa007501.13890274
42Calcium signaling pathway_Homo sapiens_hsa040201.08366935
43Estrogen signaling pathway_Homo sapiens_hsa049151.06799187
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03402460
45Vibrio cholerae infection_Homo sapiens_hsa051101.01651100
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.01447865
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00300727
48Insulin signaling pathway_Homo sapiens_hsa049100.98118613
49Central carbon metabolism in cancer_Homo sapiens_hsa052300.96587236
50Nitrogen metabolism_Homo sapiens_hsa009100.96329720
51Type II diabetes mellitus_Homo sapiens_hsa049300.94465842
52cAMP signaling pathway_Homo sapiens_hsa040240.93280463
53Thyroid cancer_Homo sapiens_hsa052160.90701914
54Parkinsons disease_Homo sapiens_hsa050120.87376123
55Glucagon signaling pathway_Homo sapiens_hsa049220.86860173
56Melanogenesis_Homo sapiens_hsa049160.84964353
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83339584
58Bile secretion_Homo sapiens_hsa049760.81398372
59VEGF signaling pathway_Homo sapiens_hsa043700.80732190
60Salmonella infection_Homo sapiens_hsa051320.78930823
61Alzheimers disease_Homo sapiens_hsa050100.77185507
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.76180029
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.75766455
64Arginine and proline metabolism_Homo sapiens_hsa003300.74730192
65Thyroid hormone synthesis_Homo sapiens_hsa049180.73997252
66Oxidative phosphorylation_Homo sapiens_hsa001900.73400849
67Endocytosis_Homo sapiens_hsa041440.72589154
68Axon guidance_Homo sapiens_hsa043600.72366069
69Melanoma_Homo sapiens_hsa052180.71328233
70Cocaine addiction_Homo sapiens_hsa050300.70264814
71Prion diseases_Homo sapiens_hsa050200.70114910
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69646634
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68059009
74MAPK signaling pathway_Homo sapiens_hsa040100.67444184
75Endometrial cancer_Homo sapiens_hsa052130.67284471
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.65692119
77Inositol phosphate metabolism_Homo sapiens_hsa005620.65020449
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64669069
79mTOR signaling pathway_Homo sapiens_hsa041500.64620309
80Prolactin signaling pathway_Homo sapiens_hsa049170.63585820
81Circadian rhythm_Homo sapiens_hsa047100.62830495
82Pancreatic secretion_Homo sapiens_hsa049720.62370018
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61968281
84Phototransduction_Homo sapiens_hsa047440.60327100
85Ras signaling pathway_Homo sapiens_hsa040140.58678931
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.58512584
87Choline metabolism in cancer_Homo sapiens_hsa052310.57790068
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57242642
89Mineral absorption_Homo sapiens_hsa049780.57068421
90Pyruvate metabolism_Homo sapiens_hsa006200.56679097
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55329642
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.55108871
93Alcoholism_Homo sapiens_hsa050340.50694758
94Rap1 signaling pathway_Homo sapiens_hsa040150.50427793
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50357597
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46198664
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44343252
98Huntingtons disease_Homo sapiens_hsa050160.42552630
99Phagosome_Homo sapiens_hsa041450.39551417
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36977399
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36849899
102Dilated cardiomyopathy_Homo sapiens_hsa054140.36467944
103Non-small cell lung cancer_Homo sapiens_hsa052230.35767974
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35192203
105Regulation of autophagy_Homo sapiens_hsa041400.34699472
106Folate biosynthesis_Homo sapiens_hsa007900.34293936
107Fructose and mannose metabolism_Homo sapiens_hsa000510.34247445
108Tight junction_Homo sapiens_hsa045300.33426293
109Arginine biosynthesis_Homo sapiens_hsa002200.31181278
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.29226030
111beta-Alanine metabolism_Homo sapiens_hsa004100.25918331
112Histidine metabolism_Homo sapiens_hsa003400.25641314
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.25133853
114Ovarian steroidogenesis_Homo sapiens_hsa049130.22122908
115Wnt signaling pathway_Homo sapiens_hsa043100.21971224
116Biosynthesis of amino acids_Homo sapiens_hsa012300.18767850
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18173281
118Phenylalanine metabolism_Homo sapiens_hsa003600.17937787

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