NEFHP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)8.78211375
2response to pheromone (GO:0019236)8.58067723
3plasma membrane fusion (GO:0045026)8.57307629
4chromosome condensation (GO:0030261)8.30905457
5DNA packaging (GO:0006323)8.05656451
6microtubule depolymerization (GO:0007019)7.61607844
7spermatid development (GO:0007286)7.41298424
8single strand break repair (GO:0000012)7.31793969
9protein polyglutamylation (GO:0018095)7.27394483
10protein targeting to Golgi (GO:0000042)7.02824221
11sperm-egg recognition (GO:0035036)6.91357096
12establishment of protein localization to Golgi (GO:0072600)6.85338388
13multicellular organism reproduction (GO:0032504)6.84778185
14microtubule polymerization or depolymerization (GO:0031109)6.63846161
15calcium ion-dependent exocytosis (GO:0017156)6.58813781
16retrograde transport, vesicle recycling within Golgi (GO:0000301)6.56926779
17spermatid nucleus differentiation (GO:0007289)6.37301373
18phosphatidylethanolamine biosynthetic process (GO:0006646)6.30957516
19reproduction (GO:0000003)6.21489098
20centriole replication (GO:0007099)6.10357087
21binding of sperm to zona pellucida (GO:0007339)5.96855260
22rRNA methylation (GO:0031167)5.90782527
23spermatogenesis (GO:0007283)5.86037524
24male gamete generation (GO:0048232)5.83901366
25phosphatidylethanolamine metabolic process (GO:0046337)5.80319982
26cell-cell recognition (GO:0009988)5.69745147
27axonemal dynein complex assembly (GO:0070286)5.59166916
28microtubule severing (GO:0051013)5.53332629
29regulation of Rab GTPase activity (GO:0032313)5.48551064
30positive regulation of Rab GTPase activity (GO:0032851)5.48551064
31negative regulation of inclusion body assembly (GO:0090084)5.39643708
32sexual reproduction (GO:0019953)5.37536783
33regulation of transcription involved in cell fate commitment (GO:0060850)5.36388207
34gamete generation (GO:0007276)5.35201884
35centriole assembly (GO:0098534)5.33745838
36regulation of centriole replication (GO:0046599)5.13808115
37protein localization to Golgi apparatus (GO:0034067)4.98332467
38rRNA modification (GO:0000154)4.97090643
39seminiferous tubule development (GO:0072520)4.85743831
40regulation of cilium movement (GO:0003352)4.80567422
41cilium or flagellum-dependent cell motility (GO:0001539)4.79849919
42cell wall macromolecule metabolic process (GO:0044036)4.76586576
43cell wall macromolecule catabolic process (GO:0016998)4.72701651
44single fertilization (GO:0007338)4.71245364
45cellular ketone body metabolic process (GO:0046950)4.66064095
46motile cilium assembly (GO:0044458)4.60093176
47RNA destabilization (GO:0050779)4.48037396
48musculoskeletal movement (GO:0050881)4.32984247
49multicellular organismal movement (GO:0050879)4.32984247
50multicellular organismal reproductive process (GO:0048609)4.27276243
51germ cell development (GO:0007281)4.17799939
52ketone body metabolic process (GO:1902224)4.09672495
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.07410535
54coenzyme catabolic process (GO:0009109)4.02948652
55fertilization (GO:0009566)4.02120079
56epithelial cilium movement (GO:0003351)3.98180163
57regulation of inclusion body assembly (GO:0090083)3.93716857
58chromatin silencing (GO:0006342)3.80653465
59organic cation transport (GO:0015695)3.73085650
60regulation of microtubule-based movement (GO:0060632)3.66793047
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61182467
62Golgi to endosome transport (GO:0006895)3.57923633
63cilium movement (GO:0003341)3.54080362
64nucleus organization (GO:0006997)3.49028202
65negative regulation of Rho protein signal transduction (GO:0035024)3.48061284
66regulation of somitogenesis (GO:0014807)3.40099470
67microtubule nucleation (GO:0007020)3.34017546
68response to acidic pH (GO:0010447)3.28043655
69cerebral cortex neuron differentiation (GO:0021895)3.26543916
70membrane protein intracellular domain proteolysis (GO:0031293)3.26412147
71peptidyl-threonine dephosphorylation (GO:0035970)3.22044097
72mesenchymal cell differentiation involved in kidney development (GO:0072161)3.14549803
73mesenchymal cell differentiation involved in renal system development (GO:2001012)3.14549803
74NAD biosynthetic process (GO:0009435)3.12876035
75polyamine biosynthetic process (GO:0006596)3.12596336
76cellular response to pH (GO:0071467)3.10804816
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.10130985
78glycerol ether metabolic process (GO:0006662)3.07927220
79regulation of interleukin-13 production (GO:0032656)2.96487434
80multicellular organismal development (GO:0007275)2.84082800
81ether metabolic process (GO:0018904)2.83917578
82cell recognition (GO:0008037)2.82802920
83regulation of T-helper 2 cell differentiation (GO:0045628)2.81470094
84protein depolymerization (GO:0051261)2.80625646
85regulation of phosphoprotein phosphatase activity (GO:0043666)2.79948018
86histone H3-K9 demethylation (GO:0033169)2.74517134
87homeostasis of number of cells within a tissue (GO:0048873)2.74248255
88outer ear morphogenesis (GO:0042473)2.74127530
89detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.73146726
90nucleosome disassembly (GO:0006337)2.72470951
91protein-DNA complex disassembly (GO:0032986)2.72470951
92regulation of female gonad development (GO:2000194)2.71005987
93cell differentiation involved in metanephros development (GO:0072202)2.70399915
94receptor recycling (GO:0001881)2.70022347
95vesicle transport along microtubule (GO:0047496)2.66776815
96cranial nerve morphogenesis (GO:0021602)2.63509970
97neurofilament cytoskeleton organization (GO:0060052)2.61497767
98fusion of sperm to egg plasma membrane (GO:0007342)11.3189478
99acrosome reaction (GO:0007340)11.2957976
100sperm motility (GO:0030317)11.1729587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.79663871
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.45275929
3EZH2_22144423_ChIP-Seq_EOC_Human2.95921461
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.69143403
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41551620
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31980989
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.30242187
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.24510717
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24510717
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.15139037
11CBP_20019798_ChIP-Seq_JUKART_Human2.15139037
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.05688864
13FUS_26573619_Chip-Seq_HEK293_Human1.94852984
14DROSHA_22980978_ChIP-Seq_HELA_Human1.92603934
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89860608
16ELF1_20517297_ChIP-Seq_JURKAT_Human1.86361745
17EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81925101
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.81763530
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.80038779
20RAC3_21632823_ChIP-Seq_H3396_Human1.74525836
21RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.72950754
22EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.72891911
23ERA_21632823_ChIP-Seq_H3396_Human1.72835384
24NANOG_20526341_ChIP-Seq_ESCs_Human1.70370244
25AR_21572438_ChIP-Seq_LNCaP_Human1.70263258
26CTCF_27219007_Chip-Seq_Bcells_Human1.67060089
27UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.65844168
28ER_23166858_ChIP-Seq_MCF-7_Human1.60968776
29MYC_19829295_ChIP-Seq_ESCs_Human1.60025397
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59829754
31SMC4_20622854_ChIP-Seq_HELA_Human1.58880665
32WDR5_24793694_ChIP-Seq_LNCAP_Human1.56091114
33YY1_22570637_ChIP-Seq_MALME-3M_Human1.55615838
34BCL6_27268052_Chip-Seq_Bcells_Human1.55536756
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53157121
36EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.51362284
37SMAD4_21741376_ChIP-Seq_EPCs_Human1.51051023
38E2F1_20622854_ChIP-Seq_HELA_Human1.50981834
39TAF15_26573619_Chip-Seq_HEK293_Human1.50684630
40TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50608846
41TAF2_19829295_ChIP-Seq_ESCs_Human1.48201584
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.47296072
43CTCF_20526341_ChIP-Seq_ESCs_Human1.45459718
44ZNF274_21170338_ChIP-Seq_K562_Hela1.44230010
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43189482
46PHF8_20622854_ChIP-Seq_HELA_Human1.42431915
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.42323964
48OCT4_20526341_ChIP-Seq_ESCs_Human1.38434409
49P68_20966046_ChIP-Seq_HELA_Human1.38214634
50ERG_20517297_ChIP-Seq_VCAP_Human1.35781501
51AR_25329375_ChIP-Seq_VCAP_Human1.35775208
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35463944
53BCOR_27268052_Chip-Seq_Bcells_Human1.35273794
54TP63_22573176_ChIP-Seq_HFKS_Human1.33249718
55PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.33171378
56RBPJ_21746931_ChIP-Seq_IB4_Human1.31997714
57P300_19829295_ChIP-Seq_ESCs_Human1.31562601
58HNFA_21074721_ChIP-Seq_CACO-2_Human1.30127218
59SMAD3_21741376_ChIP-Seq_ESCs_Human1.29502963
60P300_27268052_Chip-Seq_Bcells_Human1.28805851
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27598578
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25885544
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.24913110
64ETV1_20927104_ChIP-Seq_GIST48_Human1.24742960
65NFYB_21822215_ChIP-Seq_K562_Human1.24466326
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24005833
67REST_21632747_ChIP-Seq_MESCs_Mouse1.23973708
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23365332
69CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22896223
70TBL1_22424771_ChIP-Seq_293T_Human1.22710832
71TP53_18474530_ChIP-ChIP_U2OS_Human1.20394241
72KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19924824
73CEBPB_22108803_ChIP-Seq_LS180_Human1.19860213
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19132731
75PHF8_20622853_ChIP-Seq_HELA_Human1.19074789
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19064745
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18718316
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17586613
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17143996
80SOX2_22085726_ChIP-Seq_NPCs_Mouse1.16943406
81RUNX2_22187159_ChIP-Seq_PCA_Human1.15030473
82P53_21459846_ChIP-Seq_SAOS-2_Human1.13717534
83GATA3_21878914_ChIP-Seq_MCF-7_Human1.13652735
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11682262
85LXR_22292898_ChIP-Seq_THP-1_Human1.09262169
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08634497
87SMRT_27268052_Chip-Seq_Bcells_Human1.08496558
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08109166
89GATA6_21074721_ChIP-Seq_CACO-2_Human1.07941080
90SMAD4_21741376_ChIP-Seq_HESCs_Human1.07730293
91STAT3_23295773_ChIP-Seq_U87_Human1.05351549
92JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05079857
93NANOG_19829295_ChIP-Seq_ESCs_Human1.04788566
94SOX2_19829295_ChIP-Seq_ESCs_Human1.04788566
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04031329
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.03373858
97NFYA_21822215_ChIP-Seq_K562_Human1.02835752
98RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02790214
99SA1_27219007_Chip-Seq_Bcells_Human1.01703662
100SMAD4_21799915_ChIP-Seq_A2780_Human1.01205096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.32619731
2MP0005377_hearing/vestibular/ear_phenot4.99173720
3MP0003878_abnormal_ear_physiology4.99173720
4MP0005670_abnormal_white_adipose4.57317596
5MP0003698_abnormal_male_reproductive3.90808286
6MP0001929_abnormal_gametogenesis3.38241254
7MP0001348_abnormal_lacrimal_gland2.68811289
8MP0000678_abnormal_parathyroid_gland2.25836673
9MP0003646_muscle_fatigue2.23589623
10MP0002161_abnormal_fertility/fecundity2.20367306
11MP0005410_abnormal_fertilization10.6130969
12MP0003718_maternal_effect1.98962816
13MP0005423_abnormal_somatic_nervous1.84500547
14MP0001485_abnormal_pinna_reflex1.81841986
15MP0005451_abnormal_body_composition1.80974841
16MP0001486_abnormal_startle_reflex1.60780216
17MP0002210_abnormal_sex_determination1.54958575
18MP0004742_abnormal_vestibular_system1.54733952
19MP0001905_abnormal_dopamine_level1.52997623
20MP0004859_abnormal_synaptic_plasticity1.50108978
21MP0005379_endocrine/exocrine_gland_phen1.49076547
22MP0002735_abnormal_chemical_nociception1.44284801
23MP0003879_abnormal_hair_cell1.38872058
24MP0002234_abnormal_pharynx_morphology1.36296161
25MP0002132_abnormal_respiratory_system1.35289624
26MP0002249_abnormal_larynx_morphology1.34332523
27MP0003011_delayed_dark_adaptation1.33751275
28MP0001765_abnormal_ion_homeostasis1.33117280
29MP0008569_lethality_at_weaning1.32800929
30MP0001968_abnormal_touch/_nociception1.32536616
31MP0009046_muscle_twitch1.31056527
32MP0001963_abnormal_hearing_physiology1.29505560
33MP0000653_abnormal_sex_gland1.26644027
34MP0001145_abnormal_male_reproductive1.26600705
35MP0000569_abnormal_digit_pigmentation1.20344919
36MP0002138_abnormal_hepatobiliary_system1.18099060
37MP0002229_neurodegeneration1.15422031
38MP0005310_abnormal_salivary_gland1.12267532
39MP0000026_abnormal_inner_ear1.09840448
40MP0000534_abnormal_ureter_morphology1.08081989
41MP0001529_abnormal_vocalization1.06920194
42MP0000955_abnormal_spinal_cord1.06679963
43MP0004510_myositis1.06275721
44MP0002067_abnormal_sensory_capabilities1.06157536
45MP0002557_abnormal_social/conspecific_i1.04285418
46MP0002282_abnormal_trachea_morphology1.03644418
47MP0001440_abnormal_grooming_behavior1.00342106
48MP0005551_abnormal_eye_electrophysiolog0.99978321
49MP0005083_abnormal_biliary_tract0.98914419
50MP0000049_abnormal_middle_ear0.98734583
51MP0003329_amyloid_beta_deposits0.97325326
52MP0002572_abnormal_emotion/affect_behav0.96268980
53MP0002733_abnormal_thermal_nociception0.93622930
54MP0002272_abnormal_nervous_system0.92723751
55MP0009053_abnormal_anal_canal0.92403031
56MP0004085_abnormal_heartbeat0.91116278
57MP0005395_other_phenotype0.89636386
58MP0009745_abnormal_behavioral_response0.88549248
59MP0006276_abnormal_autonomic_nervous0.86918686
60MP0002127_abnormal_cardiovascular_syste0.84551763
61MP0005253_abnormal_eye_physiology0.77621902
62MP0001501_abnormal_sleep_pattern0.77597555
63MP0003880_abnormal_central_pattern0.77547804
64MP0003137_abnormal_impulse_conducting0.73257221
65MP0001188_hyperpigmentation0.72808626
66MP0003635_abnormal_synaptic_transmissio0.71701261
67MP0000566_synostosis0.71241316
68MP0008877_abnormal_DNA_methylation0.71131867
69MP0005085_abnormal_gallbladder_physiolo0.70698830
70MP0001666_abnormal_nutrient_absorption0.70488211
71MP0001970_abnormal_pain_threshold0.68922263
72MP0000681_abnormal_thyroid_gland0.62954204
73MP0005636_abnormal_mineral_homeostasis0.61837429
74MP0005248_abnormal_Harderian_gland0.61834707
75MP0005666_abnormal_adipose_tissue0.61603091
76MP0002734_abnormal_mechanical_nocicepti0.61469483
77MP0000015_abnormal_ear_pigmentation0.61332428
78MP0009115_abnormal_fat_cell0.57354382
79MP0005375_adipose_tissue_phenotype0.54435616
80MP0008789_abnormal_olfactory_epithelium0.53843429
81MP0005535_abnormal_body_temperature0.52694999
82MP0000516_abnormal_urinary_system0.51712846
83MP0005367_renal/urinary_system_phenotyp0.51712846
84MP0001270_distended_abdomen0.50873070
85MP0004484_altered_response_of0.50621107
86MP0003632_abnormal_nervous_system0.50049710
87MP0004811_abnormal_neuron_physiology0.49926084
88MP0003693_abnormal_embryo_hatching0.49789983
89MP0000003_abnormal_adipose_tissue0.49205176
90MP0004233_abnormal_muscle_weight0.49199246
91MP0000470_abnormal_stomach_morphology0.48828088
92MP0003631_nervous_system_phenotype0.47985377
93MP0002064_seizures0.47022391
94MP0002882_abnormal_neuron_morphology0.45747695
95MP0000230_abnormal_systemic_arterial0.42782453
96MP0008995_early_reproductive_senescence0.41723951
97MP0009697_abnormal_copulation0.40944306
98MP0004270_analgesia0.40870573
99MP0000604_amyloidosis0.39704751
100MP0005332_abnormal_amino_acid0.39115203

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.57893287
2Asymmetric septal hypertrophy (HP:0001670)5.77549800
3Attenuation of retinal blood vessels (HP:0007843)5.03964783
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.00128032
5Absent/shortened dynein arms (HP:0200106)5.00128032
6Bony spicule pigmentary retinopathy (HP:0007737)4.94032222
7Bell-shaped thorax (HP:0001591)4.71262872
8Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.49640292
9Tubulointerstitial nephritis (HP:0001970)4.37457062
10Hypoplastic ischia (HP:0003175)4.25174249
11Male infertility (HP:0003251)4.16436295
12Abnormal rod and cone electroretinograms (HP:0008323)4.11847039
13Hyperkalemia (HP:0002153)4.10158911
14Chronic hepatic failure (HP:0100626)4.09702618
15Abnormal ciliary motility (HP:0012262)4.05271513
16Resting tremor (HP:0002322)3.94728971
17Abnormal respiratory motile cilium physiology (HP:0012261)3.90473964
18Abnormal respiratory motile cilium morphology (HP:0005938)3.82848070
19Abnormal respiratory epithelium morphology (HP:0012253)3.82848070
20Enlarged epiphyses (HP:0010580)3.82694035
21Facial shape deformation (HP:0011334)3.81599944
22Potter facies (HP:0002009)3.81599944
23Abnormality of the ischium (HP:0003174)3.73183024
24Abnormality of macular pigmentation (HP:0008002)3.72485331
25Progressive cerebellar ataxia (HP:0002073)3.68944085
26Nephronophthisis (HP:0000090)3.63639567
27Infertility (HP:0000789)3.62816560
28Cone-rod dystrophy (HP:0000548)3.47600668
29Aplasia/Hypoplasia of the earlobes (HP:0009906)3.45349607
30Postural instability (HP:0002172)3.44174536
31Impulsivity (HP:0100710)3.35182883
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.34449368
33Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.30750615
34Nasal polyposis (HP:0100582)3.29411714
35Truncal obesity (HP:0001956)3.27465576
36Epiphyseal dysplasia (HP:0002656)3.26532751
37Amelogenesis imperfecta (HP:0000705)3.08799147
38Hypoplasia of the thymus (HP:0000778)3.01406878
39Abnormality of the renal medulla (HP:0100957)2.93151468
40Abnormality of dental color (HP:0011073)2.88397791
41Abnormal spermatogenesis (HP:0008669)2.85156431
42Abnormal urine output (HP:0012590)2.79399243
43Generalized aminoaciduria (HP:0002909)2.77860899
44Unilateral renal agenesis (HP:0000122)2.75740714
45Abnormality of the aortic arch (HP:0012303)2.63374206
46Menstrual irregularities (HP:0000858)2.59729806
47Abnormality of the nasal mucosa (HP:0000433)2.56862371
48Azoospermia (HP:0000027)2.56858344
49Abnormal drinking behavior (HP:0030082)2.47729911
50Polydipsia (HP:0001959)2.47729911
51Abnormality of potassium homeostasis (HP:0011042)2.45875450
52Hypoalphalipoproteinemia (HP:0003233)2.43957442
53Stage 5 chronic kidney disease (HP:0003774)2.41882707
54Abnormality of renal excretion (HP:0011036)2.40855687
55Failure to thrive in infancy (HP:0001531)2.40781568
56Mixed hearing impairment (HP:0000410)2.35337389
57Tubulointerstitial abnormality (HP:0001969)2.31596116
58Progressive sensorineural hearing impairment (HP:0000408)2.30335925
59Rhinitis (HP:0012384)2.29533165
60Congenital malformation of the right heart (HP:0011723)2.28363510
61Double outlet right ventricle (HP:0001719)2.28363510
62Abnormality of the costochondral junction (HP:0000919)2.27930670
63Polyuria (HP:0000103)2.22965571
64Portal hypertension (HP:0001409)2.22927893
65Hypophosphatemic rickets (HP:0004912)2.22098880
66Abnormality of the parathyroid morphology (HP:0011766)2.16684560
67Renovascular hypertension (HP:0100817)2.16468031
68Bradycardia (HP:0001662)2.15222856
69Renal dysplasia (HP:0000110)2.12431341
70Insulin-resistant diabetes mellitus (HP:0000831)2.11967358
71Genetic anticipation (HP:0003743)2.08939961
72Myokymia (HP:0002411)2.08716963
73Spastic paraparesis (HP:0002313)2.05869257
74Abnormality of the hepatic vasculature (HP:0006707)2.01567523
75Decreased central vision (HP:0007663)1.99032803
76Abnormality of the pubic bones (HP:0003172)1.97929178
77Ventricular tachycardia (HP:0004756)1.97363482
78Pancreatic fibrosis (HP:0100732)1.96066783
79Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.95862540
80Absent epiphyses (HP:0010577)1.95862540
81Osteomalacia (HP:0002749)1.88856619
82Bradykinesia (HP:0002067)1.87078826
83Widely patent fontanelles and sutures (HP:0004492)1.86195094
84Protuberant abdomen (HP:0001538)1.85269549
85Hyponatremia (HP:0002902)1.82391241
86Pendular nystagmus (HP:0012043)1.79898011
87Recurrent pneumonia (HP:0006532)1.78526918
88Renal Fanconi syndrome (HP:0001994)1.76791414
89Febrile seizures (HP:0002373)1.76410218
90Vertebral clefting (HP:0008428)1.76341782
91Congenital sensorineural hearing impairment (HP:0008527)1.76213394
92Abnormality of the epiphysis of the femoral head (HP:0010574)1.70393157
93Short ribs (HP:0000773)1.70362944
94Tetany (HP:0001281)1.68677709
95Pancreatic cysts (HP:0001737)1.67516800
96Intellectual disability, moderate (HP:0002342)1.66668952
97Hyperuricemia (HP:0002149)1.66258827
98Increased purine levels (HP:0004368)1.66258827
99Impaired smooth pursuit (HP:0007772)1.64103182
100Photophobia (HP:0000613)1.63974594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.39724054
2TESK15.69557546
3DDR25.55903780
4INSRR4.30002107
5PLK23.18634192
6PNCK2.71482963
7STK382.68565127
8MAP4K22.62987063
9BRD42.59947869
10MAPK152.32881460
11CAMK1G2.18168457
12STK38L1.86164992
13PRKD31.83562627
14PIK3CG1.59201789
15MST1R1.56096668
16PTK2B1.43779967
17GRK11.43424563
18WNK11.38552676
19MAP3K91.37133362
20PDK11.26869971
21PDPK11.23772266
22CDK71.22955805
23CDK121.21579537
24ADRBK21.20662158
25PINK11.15540894
26AKT31.01800907
27MAP3K111.00027727
28DYRK1B0.97453046
29LATS10.96095770
30TESK20.92730037
31NTRK30.92285325
32STK160.91832052
33NEK60.89488631
34CAMK1D0.81772596
35PRKG20.79378727
36SIK20.78697021
37KSR20.78461776
38MAP3K20.77555695
39WNK40.76868637
40FRK0.76218019
41RPS6KA20.72585192
42PRKG10.72261214
43STK390.70317767
44CDK30.70260574
45MAP2K20.70204978
46TYRO30.66593468
47MAP3K10.63373549
48UHMK10.58912463
49BRAF0.57654750
50RPS6KA10.57637879
51PRKCG0.55471916
52RPS6KC10.53039153
53RPS6KL10.53039153
54RPS6KA60.50052956
55PRKAA20.48906915
56MAP3K40.46690287
57CDK20.45825797
58CAMK10.45672208
59MAP3K80.42581720
60GSK3B0.42439325
61ZAK0.40800603
62LATS20.39926146
63MAPK10.39285429
64TLK10.37907014
65JAK30.37506977
66FGFR30.36814270
67SGK10.35773072
68PRKCE0.35327680
69ROCK10.34845069
70PRKCB0.32936869
71MUSK0.31842677
72BMPR1B0.31382840
73MAPK80.30314866
74CDK10.29839450
75SGK2230.27436877
76SGK4940.27436877
77MTOR0.26754404
78NUAK10.23792526
79CAMK40.23537581
80MARK10.23192925
81CDK40.22619470
82OXSR10.22242165
83MAPK140.21671437
84MARK20.21468124
85PRKCZ0.21243957
86CHEK10.20922951
87BRSK10.19018275
88CSNK1A10.18504064
89BLK0.18143193
90TIE10.17841021
91PRKACB0.17751212
92CAMK2A0.17301942
93PRKACA0.17185326
94DYRK1A0.16883643
95MAPK100.16855908
96AURKA0.16482465
97AKT10.15701355
98RIPK40.15406259
99PKN10.14950195
100MAP2K10.14602393

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.79203288
2Fatty acid biosynthesis_Homo sapiens_hsa000615.73336672
3Olfactory transduction_Homo sapiens_hsa047403.92090339
4Taste transduction_Homo sapiens_hsa047422.46771388
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.29781884
6Butanoate metabolism_Homo sapiens_hsa006502.25961442
7Glycerophospholipid metabolism_Homo sapiens_hsa005641.88145551
8Phototransduction_Homo sapiens_hsa047441.83335121
9Morphine addiction_Homo sapiens_hsa050321.75307200
10Nicotine addiction_Homo sapiens_hsa050331.73717874
11Type II diabetes mellitus_Homo sapiens_hsa049301.68074831
12Dorso-ventral axis formation_Homo sapiens_hsa043201.63661448
13Nitrogen metabolism_Homo sapiens_hsa009101.50256592
14Synaptic vesicle cycle_Homo sapiens_hsa047211.48709818
15Fatty acid degradation_Homo sapiens_hsa000711.46768868
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46311440
17Circadian entrainment_Homo sapiens_hsa047131.46255826
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.44389733
19GABAergic synapse_Homo sapiens_hsa047271.42993361
20Arginine biosynthesis_Homo sapiens_hsa002201.34854987
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33160552
22Type I diabetes mellitus_Homo sapiens_hsa049401.32721827
23Salivary secretion_Homo sapiens_hsa049701.31074651
24Glutamatergic synapse_Homo sapiens_hsa047241.28489461
25Calcium signaling pathway_Homo sapiens_hsa040201.22060157
26Serotonergic synapse_Homo sapiens_hsa047261.20329549
27Phenylalanine metabolism_Homo sapiens_hsa003601.19580133
28RNA transport_Homo sapiens_hsa030131.18660061
29Cholinergic synapse_Homo sapiens_hsa047251.14542346
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.14171413
31Fatty acid metabolism_Homo sapiens_hsa012121.12273529
32Graft-versus-host disease_Homo sapiens_hsa053321.10511021
33Protein digestion and absorption_Homo sapiens_hsa049741.10149641
34Antigen processing and presentation_Homo sapiens_hsa046121.06470731
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.05242276
36Allograft rejection_Homo sapiens_hsa053301.04770475
37Glycerolipid metabolism_Homo sapiens_hsa005611.04041816
38Autoimmune thyroid disease_Homo sapiens_hsa053201.02580079
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95822807
40Renin secretion_Homo sapiens_hsa049240.94703078
41Arginine and proline metabolism_Homo sapiens_hsa003300.94690067
42ABC transporters_Homo sapiens_hsa020100.94357080
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93560434
44Endocytosis_Homo sapiens_hsa041440.92851360
45Inositol phosphate metabolism_Homo sapiens_hsa005620.89256461
46Oocyte meiosis_Homo sapiens_hsa041140.88942180
47Gastric acid secretion_Homo sapiens_hsa049710.88159475
48Adipocytokine signaling pathway_Homo sapiens_hsa049200.88048670
49Cardiac muscle contraction_Homo sapiens_hsa042600.82518619
50Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82455793
51cAMP signaling pathway_Homo sapiens_hsa040240.81771236
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80598413
53Insulin secretion_Homo sapiens_hsa049110.79914652
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79388577
55Vitamin B6 metabolism_Homo sapiens_hsa007500.78975480
56Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77573766
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76907405
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.76612488
59Renin-angiotensin system_Homo sapiens_hsa046140.73488075
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.73340889
61Retinol metabolism_Homo sapiens_hsa008300.71564506
62Bile secretion_Homo sapiens_hsa049760.68501432
63PPAR signaling pathway_Homo sapiens_hsa033200.66192254
64Estrogen signaling pathway_Homo sapiens_hsa049150.65471741
65Fat digestion and absorption_Homo sapiens_hsa049750.64821218
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64147151
67Selenocompound metabolism_Homo sapiens_hsa004500.63746445
68Alcoholism_Homo sapiens_hsa050340.60560926
69Hedgehog signaling pathway_Homo sapiens_hsa043400.58466204
70Viral myocarditis_Homo sapiens_hsa054160.58005148
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57457828
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55919441
73Long-term depression_Homo sapiens_hsa047300.53809765
74Oxytocin signaling pathway_Homo sapiens_hsa049210.52462654
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52219947
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48668064
77Pancreatic secretion_Homo sapiens_hsa049720.47192067
78Fanconi anemia pathway_Homo sapiens_hsa034600.46150291
79Tyrosine metabolism_Homo sapiens_hsa003500.43933573
80Purine metabolism_Homo sapiens_hsa002300.43561692
81Linoleic acid metabolism_Homo sapiens_hsa005910.43405456
82Cocaine addiction_Homo sapiens_hsa050300.42658365
83Tight junction_Homo sapiens_hsa045300.41988956
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41025891
85Long-term potentiation_Homo sapiens_hsa047200.38195215
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38139620
87Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37179337
88MAPK signaling pathway_Homo sapiens_hsa040100.36484833
89VEGF signaling pathway_Homo sapiens_hsa043700.35863772
90Influenza A_Homo sapiens_hsa051640.35797635
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.35110776
92Chemical carcinogenesis_Homo sapiens_hsa052040.30089667
93mTOR signaling pathway_Homo sapiens_hsa041500.29269290
94Amphetamine addiction_Homo sapiens_hsa050310.27862770
95Huntingtons disease_Homo sapiens_hsa050160.27558280
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26934289
97Sphingolipid metabolism_Homo sapiens_hsa006000.24667712
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23445811
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23217497
100Basal transcription factors_Homo sapiens_hsa030220.22697807

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