NEFM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal action potential propagation (GO:0019227)6.00782490
2synaptic vesicle maturation (GO:0016188)5.72375103
3pyrimidine nucleobase catabolic process (GO:0006208)5.45722921
4cell migration in hindbrain (GO:0021535)5.22780692
5neuromuscular process controlling posture (GO:0050884)5.12080211
6neurotransmitter secretion (GO:0007269)5.00138917
7synaptic vesicle exocytosis (GO:0016079)4.88588673
8regulation of synaptic vesicle exocytosis (GO:2000300)4.66217169
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.65747182
10glutamate secretion (GO:0014047)4.65126984
11negative regulation of dendrite morphogenesis (GO:0050774)4.64869510
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.55038306
13neuromuscular synaptic transmission (GO:0007274)4.47321723
14detection of temperature stimulus (GO:0016048)4.41091380
15negative regulation of microtubule polymerization (GO:0031115)4.41062447
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.39298998
17* axon cargo transport (GO:0008088)4.37108518
18neuronal ion channel clustering (GO:0045161)4.36613439
19nucleobase catabolic process (GO:0046113)4.35056343
20* intermediate filament organization (GO:0045109)4.31712202
21proline transport (GO:0015824)4.12254664
22axon development (GO:0061564)4.09643202
23cerebellar Purkinje cell differentiation (GO:0021702)4.07531303
24cell communication by electrical coupling (GO:0010644)4.06593905
25presynaptic membrane organization (GO:0097090)4.01776239
26neuron cell-cell adhesion (GO:0007158)4.01531931
27mitochondrion transport along microtubule (GO:0047497)4.01165987
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.01165987
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.99888718
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.98533527
31substrate-independent telencephalic tangential migration (GO:0021826)3.98533527
32establishment of mitochondrion localization (GO:0051654)3.98390011
33regulation of synaptic vesicle transport (GO:1902803)3.97810100
34behavioral response to nicotine (GO:0035095)3.95210973
35protein localization to synapse (GO:0035418)3.95166419
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.93287418
37calcium-mediated signaling using intracellular calcium source (GO:0035584)3.91013955
38gamma-aminobutyric acid transport (GO:0015812)3.90365956
39neuron-neuron synaptic transmission (GO:0007270)3.89797425
40membrane depolarization during action potential (GO:0086010)3.89539819
41activation of protein kinase A activity (GO:0034199)3.81617728
42synaptic transmission, glutamatergic (GO:0035249)3.80911114
43positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.77377280
44sodium ion export (GO:0071436)3.76900904
45neurotransmitter transport (GO:0006836)3.76662239
46postsynaptic membrane organization (GO:0001941)3.76251488
47cellular potassium ion homeostasis (GO:0030007)3.76005628
48detection of temperature stimulus involved in sensory perception (GO:0050961)3.73881621
49detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.73881621
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.71922902
51auditory behavior (GO:0031223)3.71613397
52neuronal action potential (GO:0019228)3.66814338
53neuromuscular process controlling balance (GO:0050885)3.59691262
54dendritic spine morphogenesis (GO:0060997)3.57924728
55regulation of neurotransmitter levels (GO:0001505)3.54259792
56negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.54158811
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.50024581
58cell communication involved in cardiac conduction (GO:0086065)3.49035730
59synaptic vesicle docking involved in exocytosis (GO:0016081)3.47425866
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47225889
61locomotory exploration behavior (GO:0035641)3.45256194
62anterograde axon cargo transport (GO:0008089)3.44892185
63cell differentiation in hindbrain (GO:0021533)3.43764761
64negative regulation of dendrite development (GO:2000171)3.43160965
65organelle transport along microtubule (GO:0072384)3.42491194
66plasma membrane repair (GO:0001778)3.41736902
67innervation (GO:0060384)3.41060753
68positive regulation of potassium ion transmembrane transport (GO:1901381)3.39996875
69synapse assembly (GO:0007416)3.39358298
70membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38041462
71neuromuscular process (GO:0050905)3.37752026
72glutamate receptor signaling pathway (GO:0007215)3.34409271
73adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.34126167
74regulation of vesicle fusion (GO:0031338)3.33499746
75positive regulation of potassium ion transport (GO:0043268)3.32660546
76exploration behavior (GO:0035640)3.29722092
77* intermediate filament cytoskeleton organization (GO:0045104)3.27746482
78axon extension (GO:0048675)3.27552625
79layer formation in cerebral cortex (GO:0021819)3.27110212
80presynaptic membrane assembly (GO:0097105)3.26903492
81membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.24580565
82forebrain neuron differentiation (GO:0021879)3.24376147
83* intermediate filament-based process (GO:0045103)3.23517630
84vocalization behavior (GO:0071625)3.22695271
85body morphogenesis (GO:0010171)3.21107963
86regulation of postsynaptic membrane potential (GO:0060078)3.20426410
87positive regulation of dendritic spine morphogenesis (GO:0061003)3.18617225
88L-amino acid import (GO:0043092)3.17447984
89axon regeneration (GO:0031103)3.17070720
90adult walking behavior (GO:0007628)3.16732458
91regulation of neuronal synaptic plasticity (GO:0048168)3.15496487
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.15218045
93embryonic body morphogenesis (GO:0010172)3.13357021
94regulation of excitatory postsynaptic membrane potential (GO:0060079)3.13226250
95vesicle transport along microtubule (GO:0047496)3.12784659
96response to auditory stimulus (GO:0010996)3.12590473
97retinal ganglion cell axon guidance (GO:0031290)3.09751999
98calcium ion-dependent exocytosis (GO:0017156)3.08798190
99cerebellar granule cell differentiation (GO:0021707)3.07803455
100regulation of neurotransmitter transport (GO:0051588)3.07671631
101positive regulation of neurotransmitter transport (GO:0051590)3.06409761
102negative regulation of neurotransmitter secretion (GO:0046929)3.05832057
103regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05643423
104positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05641294
105spinal cord association neuron differentiation (GO:0021527)3.05561272
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.04767999
107response to acidic pH (GO:0010447)3.02683033
108positive regulation of axon extension (GO:0045773)3.02422733
109regulation of voltage-gated calcium channel activity (GO:1901385)3.01520624
110behavioral response to cocaine (GO:0048148)3.00392769
111glycine transport (GO:0015816)3.00335120
112regulation of glutamate receptor signaling pathway (GO:1900449)3.00271124
113positive regulation of axonogenesis (GO:0050772)3.00148252
114regulation of sodium ion transmembrane transporter activity (GO:2000649)2.98980708
115regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.98295316
116mechanosensory behavior (GO:0007638)2.97396090
117response to histamine (GO:0034776)2.97320398
118positive regulation of fibroblast migration (GO:0010763)2.95582351
119short-term memory (GO:0007614)2.90204737
120dendrite morphogenesis (GO:0048813)2.90177011
121axon ensheathment in central nervous system (GO:0032291)2.88687292
122central nervous system myelination (GO:0022010)2.88687292
123synapse organization (GO:0050808)2.88123401
124membrane repolarization during action potential (GO:0086011)2.87663570
125cerebellar Purkinje cell layer development (GO:0021680)2.87542638
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.87138715
127regulation of long-term neuronal synaptic plasticity (GO:0048169)2.86187915
128dopamine receptor signaling pathway (GO:0007212)2.86178290
129membrane hyperpolarization (GO:0060081)2.86078369
130positive regulation of membrane potential (GO:0045838)2.85713487
131neuron projection extension (GO:1990138)2.85003752
132* microtubule-based transport (GO:0010970)2.84001856
133regulation of synaptic transmission, GABAergic (GO:0032228)2.83909067
134axonal fasciculation (GO:0007413)2.83323063
135neuron recognition (GO:0008038)2.82768886
136membrane depolarization (GO:0051899)2.82519699
137regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82098436
138regulation of axon extension (GO:0030516)2.81945817
139membrane repolarization (GO:0086009)2.81812158
140neuron projection extension involved in neuron projection guidance (GO:1902284)2.81713505
141regulation of translational termination (GO:0006449)2.81266158
142* cytoskeleton-dependent intracellular transport (GO:0030705)2.80904383
143regulation of synapse structural plasticity (GO:0051823)2.79433737
144transmission of nerve impulse (GO:0019226)2.78771473
145signal release (GO:0023061)2.78014120
146synaptic transmission (GO:0007268)2.74992256
147regulation of neurotransmitter secretion (GO:0046928)2.70725270
148* regulation of axonogenesis (GO:0050770)2.70175202
149potassium ion homeostasis (GO:0055075)2.69014274
150regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.68755217
151mating behavior (GO:0007617)2.68298167
152* neurofilament cytoskeleton organization (GO:0060052)10.4545551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.62659812
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.45589088
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.34253076
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.27416576
5GBX2_23144817_ChIP-Seq_PC3_Human3.09742080
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02485010
7* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.97961376
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89423061
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89423061
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.81061633
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.79975963
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.69614237
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65913039
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46992438
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45780741
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.44605918
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.39768031
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.35572360
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35235831
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33639017
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28121160
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.24150223
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19853938
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.07972493
25TAF15_26573619_Chip-Seq_HEK293_Human2.03914381
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.03746746
27* RARB_27405468_Chip-Seq_BRAIN_Mouse2.02384914
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01578942
29DROSHA_22980978_ChIP-Seq_HELA_Human1.99825520
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93497713
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84177056
32NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75500523
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71366217
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69524812
35* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69500278
36AR_21572438_ChIP-Seq_LNCaP_Human1.68634199
37IGF1R_20145208_ChIP-Seq_DFB_Human1.60446542
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59231675
39SMAD4_21799915_ChIP-Seq_A2780_Human1.57657226
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.53921556
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52595900
42ZNF274_21170338_ChIP-Seq_K562_Hela1.51541843
43* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51368547
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50920314
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.44006727
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41240599
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35438104
48KDM2B_26808549_Chip-Seq_K562_Human1.34882615
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.33576584
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30518982
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29935891
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29430538
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26431993
54TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21312820
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21080220
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19547882
57* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18556946
58SOX2_21211035_ChIP-Seq_LN229_Gbm1.18349065
59CTCF_27219007_Chip-Seq_Bcells_Human1.17945799
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15734331
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15567708
62ESR2_21235772_ChIP-Seq_MCF-7_Human1.14186821
63EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14186517
64AR_25329375_ChIP-Seq_VCAP_Human1.11416888
65RNF2_27304074_Chip-Seq_NSC_Mouse1.10999007
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10775815
67P300_19829295_ChIP-Seq_ESCs_Human1.10180580
68CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.08357208
69* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08356934
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07808241
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07534068
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05594777
73* AR_19668381_ChIP-Seq_PC3_Human1.05465442
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05273981
75ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05115137
76* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04807620
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02456863
78* STAT3_23295773_ChIP-Seq_U87_Human1.01913059
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00948424
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.00660977
81AHR_22903824_ChIP-Seq_MCF-7_Human0.99420471
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.98960657
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98802572
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98529625
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.97709741
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97090667
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97090667
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96969775
89RING1B_27294783_Chip-Seq_NPCs_Mouse0.96351065
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96260724
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94979957
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.94568302
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92751135
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92343276
95STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91927684
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.89591690
97P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89328388
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88923795
99YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87012956
100KLF4_19829295_ChIP-Seq_ESCs_Human0.86682981
101* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86519607
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.84976580
103* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84821980
104POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83643245
105FUS_26573619_Chip-Seq_HEK293_Human0.83416100
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83252087
107OCT4_19829295_ChIP-Seq_ESCs_Human0.83112232
108TCF4_23295773_ChIP-Seq_U87_Human0.82881843
109* TP53_20018659_ChIP-ChIP_R1E_Mouse0.82830809
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81993641
111NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.81976587
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81779543
113PIAS1_25552417_ChIP-Seq_VCAP_Human0.81777554
114* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81369645
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80825237
116BCAT_22108803_ChIP-Seq_LS180_Human0.80382131
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.79857552
118JUN_21703547_ChIP-Seq_K562_Human0.79813575
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.79449280
120SMAD4_21741376_ChIP-Seq_EPCs_Human0.79054655
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.78319919
122REST_19997604_ChIP-ChIP_NEURONS_Mouse0.77957266
123* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75270593
124ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.74899540
125STAT3_18555785_ChIP-Seq_MESCs_Mouse0.74730149
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.71353670
127RUNX1_26923725_Chip-Seq_HPCs_Mouse0.68252320

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception4.77226425
2MP0004859_abnormal_synaptic_plasticity4.58065508
3MP0004270_analgesia4.27025361
4MP0001968_abnormal_touch/_nociception4.16497604
5MP0003880_abnormal_central_pattern4.09776036
6MP0002736_abnormal_nociception_after3.78969441
7MP0004858_abnormal_nervous_system3.63003603
8MP0006276_abnormal_autonomic_nervous3.58000478
9MP0002734_abnormal_mechanical_nocicepti3.52196908
10MP0003635_abnormal_synaptic_transmissio3.34199661
11MP0002733_abnormal_thermal_nociception3.13508929
12MP0009046_muscle_twitch3.13446807
13MP0002184_abnormal_innervation2.79894510
14MP0001970_abnormal_pain_threshold2.78890050
15MP0003123_paternal_imprinting2.71512223
16MP0004142_abnormal_muscle_tone2.69711394
17MP0005423_abnormal_somatic_nervous2.62644488
18* MP0002272_abnormal_nervous_system2.59583925
19MP0001188_hyperpigmentation2.58033810
20MP0002064_seizures2.56475582
21MP0009745_abnormal_behavioral_response2.54151760
22MP0002063_abnormal_learning/memory/cond2.41468812
23* MP0000955_abnormal_spinal_cord2.39510713
24MP0003329_amyloid_beta_deposits2.31370983
25MP0002067_abnormal_sensory_capabilities2.22945563
26MP0001486_abnormal_startle_reflex2.11625970
27* MP0004811_abnormal_neuron_physiology1.99427532
28MP0001348_abnormal_lacrimal_gland1.94042790
29MP0002572_abnormal_emotion/affect_behav1.93242377
30MP0008569_lethality_at_weaning1.75980274
31MP0000778_abnormal_nervous_system1.75187433
32MP0003121_genomic_imprinting1.69929640
33MP0001986_abnormal_taste_sensitivity1.67987952
34* MP0002882_abnormal_neuron_morphology1.60771641
35MP0004147_increased_porphyrin_level1.56886470
36MP0002909_abnormal_adrenal_gland1.56716262
37MP0001440_abnormal_grooming_behavior1.55607489
38MP0002653_abnormal_ependyma_morphology1.50111768
39MP0004924_abnormal_behavior1.48429904
40MP0005386_behavior/neurological_phenoty1.48429904
41MP0002751_abnormal_autonomic_nervous1.47483113
42MP0002638_abnormal_pupillary_reflex1.42367720
43MP0002557_abnormal_social/conspecific_i1.41796200
44MP0002066_abnormal_motor_capabilities/c1.40490907
45MP0003633_abnormal_nervous_system1.40387649
46MP0000751_myopathy1.40070933
47* MP0002229_neurodegeneration1.37846956
48MP0001501_abnormal_sleep_pattern1.34979102
49MP0005646_abnormal_pituitary_gland1.34524273
50MP0005623_abnormal_meninges_morphology1.25606101
51* MP0002752_abnormal_somatic_nervous1.20093168
52MP0000604_amyloidosis1.19192744
53MP0002332_abnormal_exercise_endurance1.18957376
54MP0001299_abnormal_eye_distance/1.18893617
55MP0000534_abnormal_ureter_morphology1.17811372
56MP0004133_heterotaxia1.16696911
57MP0003631_nervous_system_phenotype1.15060774
58MP0003879_abnormal_hair_cell1.14118655
59MP0001529_abnormal_vocalization1.13781671
60MP0005394_taste/olfaction_phenotype1.13105430
61MP0005499_abnormal_olfactory_system1.13105430
62MP0008877_abnormal_DNA_methylation1.12954066
63MP0003634_abnormal_glial_cell1.11888608
64MP0009379_abnormal_foot_pigmentation1.10659616
65MP0003385_abnormal_body_wall1.08696626
66MP0002163_abnormal_gland_morphology1.05909836
67MP0004145_abnormal_muscle_electrophysio1.02986057
68MP0001346_abnormal_lacrimal_gland1.00575238
69MP0000920_abnormal_myelination1.00557080
70MP0003122_maternal_imprinting0.99310694
71MP0005551_abnormal_eye_electrophysiolog0.98192054
72MP0001984_abnormal_olfaction0.96925888
73MP0002269_muscular_atrophy0.92662655
74MP0000631_abnormal_neuroendocrine_gland0.92363678
75MP0005409_darkened_coat_color0.92356390
76MP0001963_abnormal_hearing_physiology0.89239530
77MP0005083_abnormal_biliary_tract0.88658992
78MP0004134_abnormal_chest_morphology0.87394039
79MP0009780_abnormal_chondrocyte_physiolo0.85565252
80MP0002876_abnormal_thyroid_physiology0.85057298
81MP0001485_abnormal_pinna_reflex0.84440222
82MP0003890_abnormal_embryonic-extraembry0.81016082
83MP0002152_abnormal_brain_morphology0.79729259
84MP0008789_abnormal_olfactory_epithelium0.79532930
85MP0004885_abnormal_endolymph0.79173681
86MP0000747_muscle_weakness0.78469274
87MP0003119_abnormal_digestive_system0.78263234
88MP0003942_abnormal_urinary_system0.78177033
89MP0000538_abnormal_urinary_bladder0.76732436
90MP0003283_abnormal_digestive_organ0.73922783
91MP0004085_abnormal_heartbeat0.73325537
92MP0002822_catalepsy0.73072489
93MP0003011_delayed_dark_adaptation0.72491463
94MP0004742_abnormal_vestibular_system0.71855348
95MP0002837_dystrophic_cardiac_calcinosis0.71739973
96MP0000026_abnormal_inner_ear0.71514990
97MP0002928_abnormal_bile_duct0.71318944
98MP0003938_abnormal_ear_development0.71098416
99MP0002160_abnormal_reproductive_system0.70056606
100MP0002081_perinatal_lethality0.70008697
101MP0003632_abnormal_nervous_system0.69904531
102MP0005645_abnormal_hypothalamus_physiol0.67177551
103MP0008872_abnormal_physiological_respon0.67125990
104MP0001270_distended_abdomen0.66823521
105MP0006292_abnormal_olfactory_placode0.65829046
106MP0005187_abnormal_penis_morphology0.65347454
107MP0001943_abnormal_respiration0.65315549
108MP0005195_abnormal_posterior_eye0.63583835
109MP0000566_synostosis0.63507129
110MP0006072_abnormal_retinal_apoptosis0.62778998
111MP0001502_abnormal_circadian_rhythm0.62716873
112MP0001905_abnormal_dopamine_level0.62300312
113MP0008874_decreased_physiological_sensi0.60929674
114MP0000749_muscle_degeneration0.60836737
115MP0000759_abnormal_skeletal_muscle0.60181429
116MP0005535_abnormal_body_temperature0.59720066
117MP0003137_abnormal_impulse_conducting0.55846013
118MP0002069_abnormal_eating/drinking_beha0.55819798
119MP0006035_abnormal_mitochondrial_morpho0.52961274
120MP0001664_abnormal_digestion0.51435054
121MP0005410_abnormal_fertilization0.50839296
122MP0010769_abnormal_survival0.50172625
123MP0010770_preweaning_lethality0.49465744
124MP0002082_postnatal_lethality0.49465744
125MP0004036_abnormal_muscle_relaxation0.47687036
126MP0010386_abnormal_urinary_bladder0.47395822
127MP0004233_abnormal_muscle_weight0.47300028
128MP0000569_abnormal_digit_pigmentation0.46314635
129MP0010768_mortality/aging0.45906209
130* MP0003861_abnormal_nervous_system0.44780195
131MP0004883_abnormal_blood_vessel0.44650036
132MP0003956_abnormal_body_size0.44353005
133MP0001177_atelectasis0.43389105
134MP0003787_abnormal_imprinting0.43195849

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)9.08347086
2Myokymia (HP:0002411)7.58793398
3Segmental peripheral demyelination/remyelination (HP:0003481)5.69827448
4Supranuclear gaze palsy (HP:0000605)5.39970055
5Action tremor (HP:0002345)5.07573253
6Pheochromocytoma (HP:0002666)5.06891735
7Neuroendocrine neoplasm (HP:0100634)4.51290836
8Focal motor seizures (HP:0011153)4.29480294
9Hammertoe (HP:0001765)4.26085118
10Termporal pattern (HP:0011008)4.20215424
11Insidious onset (HP:0003587)4.20215424
12Focal seizures (HP:0007359)4.11312684
13Limb dystonia (HP:0002451)4.04466613
14Foot dorsiflexor weakness (HP:0009027)4.04160921
15Atonic seizures (HP:0010819)4.01985574
16Steppage gait (HP:0003376)3.97534054
17Febrile seizures (HP:0002373)3.81621071
18Ankle clonus (HP:0011448)3.76490569
19Progressive cerebellar ataxia (HP:0002073)3.73725768
20Abnormality of the foot musculature (HP:0001436)3.66387713
21Abnormality of the vocal cords (HP:0008777)3.64518130
22Onion bulb formation (HP:0003383)3.43349701
23Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.41751121
24Decreased motor nerve conduction velocity (HP:0003431)3.37258940
25Neoplasm of the peripheral nervous system (HP:0100007)3.15223131
26Visual hallucinations (HP:0002367)3.12110732
27Urinary urgency (HP:0000012)3.11876321
28Distal sensory impairment (HP:0002936)3.08990395
29Hepatoblastoma (HP:0002884)3.07489131
30Failure to thrive in infancy (HP:0001531)3.05386980
31Ventricular fibrillation (HP:0001663)3.02658512
32Polyphagia (HP:0002591)2.99551023
33Absence seizures (HP:0002121)2.99393839
34Hypercortisolism (HP:0001578)2.98721916
35Gait imbalance (HP:0002141)2.88013976
36Epileptic encephalopathy (HP:0200134)2.87654046
37Spastic gait (HP:0002064)2.85716381
38Abnormal pancreas size (HP:0012094)2.85393171
39Generalized tonic-clonic seizures (HP:0002069)2.83905112
40Abnormality of the corticospinal tract (HP:0002492)2.80048595
41Impaired pain sensation (HP:0007328)2.80009438
42Abnormality of pain sensation (HP:0010832)2.80009438
43Broad-based gait (HP:0002136)2.80008157
44Drooling (HP:0002307)2.79308042
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.75372285
46Truncal ataxia (HP:0002078)2.69769025
47Slow saccadic eye movements (HP:0000514)2.65818815
48Urinary bladder sphincter dysfunction (HP:0002839)2.61601646
49Dialeptic seizures (HP:0011146)2.60030906
50Amblyopia (HP:0000646)2.59714955
51Status epilepticus (HP:0002133)2.57822876
52Abnormality of the lower motor neuron (HP:0002366)2.56650316
53Abnormality of the musculature of the hand (HP:0001421)2.55419427
54Excessive salivation (HP:0003781)2.54602195
55Impaired vibration sensation in the lower limbs (HP:0002166)2.51939203
56Poor suck (HP:0002033)2.51316690
57Hypoventilation (HP:0002791)2.42386360
58Epileptiform EEG discharges (HP:0011182)2.41708358
59Aplasia/Hypoplasia of the brainstem (HP:0007362)2.41158796
60Hypoplasia of the brainstem (HP:0002365)2.41158796
61Abnormal eating behavior (HP:0100738)2.40019549
62Muscle stiffness (HP:0003552)2.39619339
63Spastic tetraplegia (HP:0002510)2.38788175
64Nephrogenic diabetes insipidus (HP:0009806)2.38517396
65Myotonia (HP:0002486)2.35757504
66Paraplegia (HP:0010550)2.29361935
67Insomnia (HP:0100785)2.28191895
68Scanning speech (HP:0002168)2.27389863
69Dysmetria (HP:0001310)2.25709798
70Peripheral hypomyelination (HP:0007182)2.25554295
71Congenital primary aphakia (HP:0007707)2.24516986
72Anxiety (HP:0000739)2.22490301
73Depression (HP:0000716)2.22019165
74Lower limb muscle weakness (HP:0007340)2.21489813
75EEG with generalized epileptiform discharges (HP:0011198)2.21080569
76Vaginal atresia (HP:0000148)2.20447433
77Spastic paraplegia (HP:0001258)2.18207234
78Cerebral hypomyelination (HP:0006808)2.16776234
79Incomplete penetrance (HP:0003829)2.16317882
80Medial flaring of the eyebrow (HP:0010747)2.15224218
81Hypsarrhythmia (HP:0002521)2.14319241
82Genital tract atresia (HP:0001827)2.13411251
83Sleep apnea (HP:0010535)2.13005304
84Mutism (HP:0002300)2.12056743
85Anomalous pulmonary venous return (HP:0010772)2.11658673
86Anosmia (HP:0000458)2.10598351
87Growth hormone deficiency (HP:0000824)2.10413946
88Intention tremor (HP:0002080)2.10127186
89Cerebral hemorrhage (HP:0001342)2.10020830
90Abnormality of calcium-phosphate metabolism (HP:0100530)2.08034670
91CNS hypomyelination (HP:0003429)2.07055528
92Neonatal hypoglycemia (HP:0001998)2.07046976
93Fetal akinesia sequence (HP:0001989)2.06888869
94Pes cavus (HP:0001761)2.04711003
95Torticollis (HP:0000473)2.04182149
96Amyotrophic lateral sclerosis (HP:0007354)2.02647981
97Diplopia (HP:0000651)1.99722895
98Abnormality of binocular vision (HP:0011514)1.99722895
99Hyporeflexia of lower limbs (HP:0002600)1.99696475
100Specific learning disability (HP:0001328)1.97150588
101Progressive external ophthalmoplegia (HP:0000590)1.95862431
102Peripheral demyelination (HP:0011096)1.95842938
103Lissencephaly (HP:0001339)1.95170932
104Pachygyria (HP:0001302)1.94935476
105Abnormality of the labia minora (HP:0012880)1.94576261
106Gaze-evoked nystagmus (HP:0000640)1.94364255
107Postural instability (HP:0002172)1.94255940
108Metaphyseal dysplasia (HP:0100255)1.93979433
109Generalized hypotonia (HP:0001290)1.93748884
110Impaired vibratory sensation (HP:0002495)1.92740684
111Akinesia (HP:0002304)1.91671155
112Neurofibrillary tangles (HP:0002185)1.91523788
113Postural tremor (HP:0002174)1.91383695
114Diastasis recti (HP:0001540)1.90230980
115Annular pancreas (HP:0001734)1.88420233
116Rapidly progressive (HP:0003678)1.88221767
117Neoplasm of the adrenal cortex (HP:0100641)1.87992437
118Dysdiadochokinesis (HP:0002075)1.86898064
119Congenital malformation of the right heart (HP:0011723)1.86186931
120Double outlet right ventricle (HP:0001719)1.86186931
121Clonus (HP:0002169)1.85875920
122Hypogonadotrophic hypogonadism (HP:0000044)1.85717139
123Hemiparesis (HP:0001269)1.85112686
124Agitation (HP:0000713)1.82886390
125Papilledema (HP:0001085)1.82744771
126Spastic tetraparesis (HP:0001285)1.82485860
127Facial shape deformation (HP:0011334)1.80942505
128Potter facies (HP:0002009)1.80942505
129Acute necrotizing encephalopathy (HP:0006965)1.80710246
130Progressive inability to walk (HP:0002505)1.80437163
131Slow progression (HP:0003677)1.80346069
132Morphological abnormality of the pyramidal tract (HP:0002062)1.80199384
133Cortical dysplasia (HP:0002539)1.79053289
134Craniofacial dystonia (HP:0012179)1.79001217
135Abnormality of the pulmonary veins (HP:0011718)1.78202407
136Hypoplasia of the corpus callosum (HP:0002079)1.76507578
137Abnormality of saccadic eye movements (HP:0000570)1.75864893
138Impaired smooth pursuit (HP:0007772)1.75456313
139Lower limb asymmetry (HP:0100559)1.74749851
140Focal dystonia (HP:0004373)1.74670323
141Impaired social interactions (HP:0000735)1.74296062
142Abnormal social behavior (HP:0012433)1.74296062
143Hyperthyroidism (HP:0000836)1.72829203
144Pointed chin (HP:0000307)1.72179363
145Degeneration of the lateral corticospinal tracts (HP:0002314)1.70473800
146Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70473800
147Poor coordination (HP:0002370)1.69201810
148Dysautonomia (HP:0002459)1.68858136
149Hyperparathyroidism (HP:0000843)1.68216873
150Retinal dysplasia (HP:0007973)1.67668964
151Delusions (HP:0000746)1.67250269
152Bradykinesia (HP:0002067)1.67190195
153Bundle branch block (HP:0011710)1.66846737
154Molar tooth sign on MRI (HP:0002419)1.65200492
155Abnormality of midbrain morphology (HP:0002418)1.65200492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.63829690
2LMTK24.31484219
3MARK14.12516906
4MAP3K93.77838722
5MAP3K123.26027652
6* MINK13.22543724
7LATS23.20920659
8MAP3K42.89967190
9LIMK12.58463862
10MAP2K42.39738238
11WNK12.34113563
12KSR22.31473605
13PHKG22.29768698
14PHKG12.29768698
15MAP2K72.23308637
16NTRK12.15372377
17TYRO32.05155942
18PAK62.03499670
19RET1.68155635
20MAP3K21.53950141
21STK391.51461708
22WNK41.48215309
23CAMKK11.47545028
24BCR1.43697309
25SCYL21.41790008
26MAPK131.40582015
27NEK11.35419161
28STK381.25026451
29CDK51.24926833
30GRK51.21867409
31MAPKAPK31.18272975
32PRKCG1.15503900
33MAP3K111.09010476
34CDK191.05630855
35DYRK1A1.05197668
36CAMKK21.03075784
37CASK1.00181684
38CAMK10.98499413
39UHMK10.97427629
40CAMK1G0.95479241
41FER0.92731842
42BRAF0.90530282
43IRAK20.86857710
44PAK30.85772327
45CAMK2G0.85561576
46GRK70.84682612
47KSR10.84363812
48EPHA40.82641788
49ARAF0.82454094
50PNCK0.82247981
51MAP2K10.79193842
52DAPK20.79029043
53CAMK2A0.76904927
54ICK0.76803327
55STK160.76490527
56CDK140.76265273
57CDC42BPA0.75410490
58ADRBK20.75339870
59MAP3K10.74755106
60RPS6KA20.74462160
61RIPK40.73161325
62WNK30.71850585
63PRKD30.70954991
64SGK4940.70800473
65SGK2230.70800473
66DYRK1B0.69652829
67NTRK20.68260287
68PINK10.68065436
69EPHA30.66005811
70FES0.64182032
71CDK180.63938739
72CSNK1G30.63791747
73ADRBK10.63428801
74ROCK20.62153038
75PRKCZ0.61509872
76CDK150.61135941
77PLK20.60303283
78CAMK1D0.60039832
79EPHB20.59796028
80PDPK10.59251205
81SGK10.57710809
82CSNK1A1L0.57107866
83PKN10.55013908
84ERBB20.54848832
85DYRK30.52292107
86MATK0.52241883
87CDK11A0.52233031
88CSNK1G20.51864278
89FGFR20.51701603
90ALK0.51655599
91PDK10.51538045
92* PRKACA0.49663680
93ROCK10.49308066
94IRAK10.49235284
95PRKCE0.48588755
96PRKG10.47389292
97TNK20.46651471
98MAPK100.46606442
99PRKCH0.46595559
100TAOK10.43424997
101DAPK10.42940764
102TRIM280.41398491
103MAPK40.41384865
104CSNK1D0.41207182
105CSNK1G10.40798444
106* MAPK80.40677958
107BMPR1B0.39663746
108PRKACB0.39493181
109* CSNK1E0.38988634
110PRKDC0.38385188
111NME10.38263602
112STK110.37485088
113* GSK3B0.36854715
114SIK20.36792592
115MAPK90.36657690
116CAMK2B0.36531907
117OXSR10.36462909
118PRKCA0.36175933
119TNIK0.36000573
120FYN0.35675946
121CAMK2D0.35267556
122MARK20.32280266
123PRKG20.31708304
124AURKA0.31222096
125SGK20.29706611
126PTK20.29248736
127TESK10.29131512
128PDK30.29005939
129PDK40.29005939
130PRKCB0.28188331
131SGK30.26781062
132BRSK10.26631809
133RPS6KA30.25723352
134DYRK20.24645252

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047214.14175668
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.14947433
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.01889518
4Olfactory transduction_Homo sapiens_hsa047402.41818352
5Nicotine addiction_Homo sapiens_hsa050332.30375022
6Cholinergic synapse_Homo sapiens_hsa047252.19885821
7Long-term potentiation_Homo sapiens_hsa047202.05727619
8* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.04198106
9Circadian entrainment_Homo sapiens_hsa047131.91556401
10Dopaminergic synapse_Homo sapiens_hsa047281.89102628
11Oxidative phosphorylation_Homo sapiens_hsa001901.75966462
12GABAergic synapse_Homo sapiens_hsa047271.74104717
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73241936
14Insulin secretion_Homo sapiens_hsa049111.71757635
15Parkinsons disease_Homo sapiens_hsa050121.70023710
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69072580
17Taste transduction_Homo sapiens_hsa047421.67748202
18Salivary secretion_Homo sapiens_hsa049701.66284453
19Cardiac muscle contraction_Homo sapiens_hsa042601.64884469
20Gastric acid secretion_Homo sapiens_hsa049711.64638084
21Amphetamine addiction_Homo sapiens_hsa050311.61650372
22Glutamatergic synapse_Homo sapiens_hsa047241.56914881
23Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.52409995
24Collecting duct acid secretion_Homo sapiens_hsa049661.50500921
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49021685
26GnRH signaling pathway_Homo sapiens_hsa049121.45611659
27Alzheimers disease_Homo sapiens_hsa050101.41119792
28Gap junction_Homo sapiens_hsa045401.37053860
29Morphine addiction_Homo sapiens_hsa050321.36478874
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32800668
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32143519
32Dorso-ventral axis formation_Homo sapiens_hsa043201.30804012
33Oxytocin signaling pathway_Homo sapiens_hsa049211.24832470
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23049101
35Vibrio cholerae infection_Homo sapiens_hsa051101.17383841
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.17048867
37Serotonergic synapse_Homo sapiens_hsa047261.16841954
38Renin secretion_Homo sapiens_hsa049241.16782540
39Glioma_Homo sapiens_hsa052141.16502556
40Axon guidance_Homo sapiens_hsa043601.15696186
41Oocyte meiosis_Homo sapiens_hsa041141.14424714
42Ribosome_Homo sapiens_hsa030101.12176971
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12109677
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11329030
45Calcium signaling pathway_Homo sapiens_hsa040201.11272540
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08306115
47Long-term depression_Homo sapiens_hsa047301.07081371
48ErbB signaling pathway_Homo sapiens_hsa040121.05384010
49Huntingtons disease_Homo sapiens_hsa050161.03875544
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02242906
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98763961
52Estrogen signaling pathway_Homo sapiens_hsa049150.98066719
53Type II diabetes mellitus_Homo sapiens_hsa049300.92502504
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89207481
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87986908
56Insulin signaling pathway_Homo sapiens_hsa049100.87242075
57cAMP signaling pathway_Homo sapiens_hsa040240.85551481
58Cocaine addiction_Homo sapiens_hsa050300.85157250
59Choline metabolism in cancer_Homo sapiens_hsa052310.84678817
60Melanogenesis_Homo sapiens_hsa049160.84296944
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.80239160
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77747460
63VEGF signaling pathway_Homo sapiens_hsa043700.76395372
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76188771
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.75320980
66Glucagon signaling pathway_Homo sapiens_hsa049220.74804891
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69285401
68Thyroid cancer_Homo sapiens_hsa052160.68598712
69Alcoholism_Homo sapiens_hsa050340.68579595
70Prion diseases_Homo sapiens_hsa050200.67995126
71Endocytosis_Homo sapiens_hsa041440.66082593
72Salmonella infection_Homo sapiens_hsa051320.64987737
73Melanoma_Homo sapiens_hsa052180.64282060
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.64100334
75Bile secretion_Homo sapiens_hsa049760.63674927
76MAPK signaling pathway_Homo sapiens_hsa040100.63268841
77Ras signaling pathway_Homo sapiens_hsa040140.61753860
78Phototransduction_Homo sapiens_hsa047440.61269595
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.60297795
80Pyruvate metabolism_Homo sapiens_hsa006200.60119216
81Regulation of autophagy_Homo sapiens_hsa041400.58985554
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57474700
83Nitrogen metabolism_Homo sapiens_hsa009100.57341372
84Phagosome_Homo sapiens_hsa041450.56057119
85Rap1 signaling pathway_Homo sapiens_hsa040150.55838035
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55617214
87Thyroid hormone synthesis_Homo sapiens_hsa049180.55415948
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54866016
89Endometrial cancer_Homo sapiens_hsa052130.54782561
90Steroid biosynthesis_Homo sapiens_hsa001000.52986158
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52045469
92Dilated cardiomyopathy_Homo sapiens_hsa054140.51787614
93Wnt signaling pathway_Homo sapiens_hsa043100.51313715
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50571068
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48813042
96Vitamin B6 metabolism_Homo sapiens_hsa007500.48804855
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48370881
982-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47564717
99Pancreatic secretion_Homo sapiens_hsa049720.47543941
100Hedgehog signaling pathway_Homo sapiens_hsa043400.47420922
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45267453
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43124485
103Hippo signaling pathway_Homo sapiens_hsa043900.42767426
104Inositol phosphate metabolism_Homo sapiens_hsa005620.42530600
105Prolactin signaling pathway_Homo sapiens_hsa049170.41080032
106mTOR signaling pathway_Homo sapiens_hsa041500.40553613
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33556995
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33303719
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33294537
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.31305538
111Basal cell carcinoma_Homo sapiens_hsa052170.31203313
112Renal cell carcinoma_Homo sapiens_hsa052110.29434889
113Notch signaling pathway_Homo sapiens_hsa043300.28465315
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28408078
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25117519
116Ether lipid metabolism_Homo sapiens_hsa005650.24898845
117Sulfur relay system_Homo sapiens_hsa041220.24851570
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23980852
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23038199
120Ovarian steroidogenesis_Homo sapiens_hsa049130.22998161
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.20543157

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