ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	neurofilament cytoskeleton organization (GO:0060052)	9.02210104
2	locomotory exploration behavior (GO:0035641)	5.54822194
3	cerebellar Purkinje cell differentiation (GO:0021702)	4.98726815
4	substrate-independent telencephalic tangential migration (GO:0021826)	4.85189897
5	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.85189897
6	pyrimidine nucleobase catabolic process (GO:0006208)	4.80126912
7	parturition (GO:0007567)	4.75226405
8	cell migration in hindbrain (GO:0021535)	4.57724749
9	establishment of mitochondrion localization (GO:0051654)	4.55540972
10	mitochondrion transport along microtubule (GO:0047497)	4.38977398
11	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	4.38977398
12	behavioral response to nicotine (GO:0035095)	4.34272755
13	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.29773562
14	ovulation cycle (GO:0042698)	4.27469913
15	gamma-aminobutyric acid transport (GO:0015812)	4.05038398
16	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.80893582
17	nucleobase catabolic process (GO:0046113)	3.75397507
18	neuron recognition (GO:0008038)	3.72321040
19	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	3.67187130
20	tachykinin receptor signaling pathway (GO:0007217)	3.63750311
21	forebrain neuron differentiation (GO:0021879)	3.61307442
22	exploration behavior (GO:0035640)	3.55592250
23	protein neddylation (GO:0045116)	3.54666094
24	axonal fasciculation (GO:0007413)	3.53595416
25	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.52771155
26	neuronal ion channel clustering (GO:0045161)	3.50767364
27	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.49200433
28	positive regulation of gastrulation (GO:2000543)	3.46048222
29	cell-cell junction maintenance (GO:0045217)	3.45108697
30	regulation of synapse structural plasticity (GO:0051823)	3.43598720
31	postsynaptic membrane organization (GO:0001941)	3.41094440
32	spinal cord association neuron differentiation (GO:0021527)	3.40605371
33	regulation of neuron migration (GO:2001222)	3.40216624
34	synaptic transmission, dopaminergic (GO:0001963)	3.40104464
35	cellular response to electrical stimulus (GO:0071257)	3.30938825
36	intermediate filament organization (GO:0045109)	3.30640506
37	regulation of glutamate receptor signaling pathway (GO:1900449)	3.29754656
38	adult walking behavior (GO:0007628)	3.28169371
39	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	3.27639468
40	cell differentiation in hindbrain (GO:0021533)	3.25234642
41	regulation of cilium movement (GO:0003352)	3.24141994
42	cell junction maintenance (GO:0034331)	3.23802330
43	presynaptic membrane organization (GO:0097090)	3.22834568
44	transmission of nerve impulse (GO:0019226)	3.17853822
45	neuron cell-cell adhesion (GO:0007158)	3.17469487
46	axon extension (GO:0048675)	3.16794066
47	uterus development (GO:0060065)	3.15777269
48	synapse assembly (GO:0007416)	3.14287972
49	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.13419758
50	phenylpropanoid metabolic process (GO:0009698)	3.12473957
51	glucocorticoid biosynthetic process (GO:0006704)	3.12222562
52	regulation of microtubule-based movement (GO:0060632)	3.08879894
53	body morphogenesis (GO:0010171)	3.08320748
54	dopamine receptor signaling pathway (GO:0007212)	3.07096048
55	negative regulation of catecholamine secretion (GO:0033604)	3.04506063
56	neuronal action potential propagation (GO:0019227)	3.02708237
57	dendrite morphogenesis (GO:0048813)	3.02470764
58	protein polyglutamylation (GO:0018095)	3.01859976
59	protein localization to synapse (GO:0035418)	3.00543029
60	ganglion development (GO:0061548)	2.98956285
61	head development (GO:0060322)	2.96797778
62	glutamate receptor signaling pathway (GO:0007215)	2.96185750
63	membrane depolarization during action potential (GO:0086010)	2.93213865
64	positive regulation of growth hormone secretion (GO:0060124)	2.89426427
65	hypothalamus development (GO:0021854)	2.87731577
66	regulation of bile acid biosynthetic process (GO:0070857)	2.86532333
67	synaptic vesicle maturation (GO:0016188)	2.86369088
68	negative regulation of neurotransmitter secretion (GO:0046929)	2.85026954
69	dendritic spine morphogenesis (GO:0060997)	2.84029091
70	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	2.82881058
71	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.81884595
72	lymphangiogenesis (GO:0001946)	2.81581754
73	neuron-neuron synaptic transmission (GO:0007270)	2.81576312
74	innervation (GO:0060384)	2.80886634
75	peripheral nervous system neuron development (GO:0048935)	2.80407895
76	regulation of gonadotropin secretion (GO:0032276)	2.79915656
77	embryonic body morphogenesis (GO:0010172)	2.78027335
78	axon cargo transport (GO:0008088)	2.76456665
79	synaptic transmission, glutamatergic (GO:0035249)	2.73819171
80	protein localization to cilium (GO:0061512)	2.71515730
81	retinal ganglion cell axon guidance (GO:0031290)	2.69568699
82	regulation of synaptic transmission, glutamatergic (GO:0051966)	2.67251183
83	glutamate secretion (GO:0014047)	2.64847550
84	negative regulation of axon extension (GO:0030517)	2.64774091
85	neuron migration (GO:0001764)	2.63392579
86	neuron projection extension (GO:1990138)	2.62888282
87	striatum development (GO:0021756)	2.61810926
88	motor neuron axon guidance (GO:0008045)	2.61351775
89	calcium ion-dependent exocytosis (GO:0017156)	2.60528743
90	regulation of potassium ion transmembrane transport (GO:1901379)	2.60374661
91	response to misfolded protein (GO:0051788)	2.59844995
92	cochlea development (GO:0090102)	2.59735104
93	nonmotile primary cilium assembly (GO:0035058)	2.58003027
94	phosphorelay signal transduction system (GO:0000160)	2.56474170
95	regulation of glycogen (starch) synthase activity (GO:2000465)	2.53188210
96	intermediate filament cytoskeleton organization (GO:0045104)	2.52331715
97	regulation of membrane repolarization (GO:0060306)	2.51113090
98	microtubule severing (GO:0051013)	2.51060108
99	response to histamine (GO:0034776)	2.50558778
100	glomerulus development (GO:0032835)	2.50148379

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.23718458
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.15366392
3	REST_21632747_ChIP-Seq_MESCs_Mouse	3.01373538
4	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.90298912
5	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.84570919
6	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.77134398
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.72449685
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.57640940
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.57615254
10	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.56858233
11	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.51337850
12	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.46364792
13	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.29976801
14	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.29471425
15	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.29471425
16	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.24735984
17	RNF2_27304074_Chip-Seq_ESCs_Mouse	2.22656567
18	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.20395592
19	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.18853773
20	RNF2_27304074_Chip-Seq_NSC_Mouse	2.17651201
21	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.13645766
22	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.12056117
23	GBX2_23144817_ChIP-Seq_PC3_Human	2.03173064
24	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.01717618
25	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.98292424
26	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.97973671
27	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.95253985
28	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.94022400
29	VDR_22108803_ChIP-Seq_LS180_Human	1.88499194
30	DROSHA_22980978_ChIP-Seq_HELA_Human	1.82821201
31	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.80845007
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.79284348
33	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.73917843
34	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.73225607
35	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.70204071
36	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.66802209
37	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.62411777
38	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.58155614
39	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.54238699
40	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.53729458
41	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.52420752
42	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.51839209
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.48794910
44	TAF15_26573619_Chip-Seq_HEK293_Human	1.41079981
45	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.40493432
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31507578
47	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.29182751
48	CTCF_27219007_Chip-Seq_Bcells_Human	1.24899529
49	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.24830647
50	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.22882613
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.21762408
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.21762408
53	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20892195
54	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.20164643
55	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.18420050
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.17592785
57	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.17383481
58	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.17337496
59	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.17291497
60	P300_19829295_ChIP-Seq_ESCs_Human	1.15897621
61	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.12758539
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11515845
63	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.11015947
64	AR_25329375_ChIP-Seq_VCAP_Human	1.07656996
65	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05198964
66	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.05150343
67	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04743903
68	CBP_20019798_ChIP-Seq_JUKART_Human	1.04743903
69	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04212004
70	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.03548183
71	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02434069
72	AR_19668381_ChIP-Seq_PC3_Human	0.99553006
73	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99405218
74	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99000331
75	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.97727414
76	IRF1_19129219_ChIP-ChIP_H3396_Human	0.96014514
77	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.95734789
78	FUS_26573619_Chip-Seq_HEK293_Human	0.94323658
79	TCF4_23295773_ChIP-Seq_U87_Human	0.93598410
80	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92775266
81	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.92714709
82	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.92275981
83	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.92126179
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92099735
85	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.91053223
86	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.90644665
87	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.89596055
88	BCAT_22108803_ChIP-Seq_LS180_Human	0.88157317
89	STAT3_23295773_ChIP-Seq_U87_Human	0.87162480
90	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86849518
91	TP53_22573176_ChIP-Seq_HFKS_Human	0.85699708
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.85245948
93	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.84959415
94	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84286342
95	JUN_21703547_ChIP-Seq_K562_Human	0.84142504
96	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.83765264
97	EWS_26573619_Chip-Seq_HEK293_Human	0.83737480
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.82219525
99	RUNX2_22187159_ChIP-Seq_PCA_Human	0.81548029
100	STAT3_18555785_ChIP-Seq_MESCs_Mouse	0.81331336

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.87511626
2	MP0003880_abnormal_central_pattern	4.50299704
3	MP0002822_catalepsy	3.91964341
4	MP0003123_paternal_imprinting	3.49945991
5	MP0006276_abnormal_autonomic_nervous	3.15546348
6	MP0005423_abnormal_somatic_nervous	2.97208811
7	MP0005646_abnormal_pituitary_gland	2.59250608
8	MP0001529_abnormal_vocalization	2.49282950
9	MP0009046_muscle_twitch	2.45318072
10	MP0004859_abnormal_synaptic_plasticity	2.35357304
11	MP0001188_hyperpigmentation	2.32696065
12	MP0000778_abnormal_nervous_system	2.28722022
13	MP0002272_abnormal_nervous_system	2.27744852
14	MP0003121_genomic_imprinting	2.21086405
15	MP0003635_abnormal_synaptic_transmissio	2.20012627
16	MP0003315_abnormal_perineum_morphology	2.10017469
17	MP0001348_abnormal_lacrimal_gland	2.08991469
18	MP0005187_abnormal_penis_morphology	2.04171590
19	MP0000955_abnormal_spinal_cord	2.02042943
20	MP0009745_abnormal_behavioral_response	1.97427562
21	MP0003890_abnormal_embryonic-extraembry	1.92282628
22	MP0002163_abnormal_gland_morphology	1.91384478
23	MP0004742_abnormal_vestibular_system	1.83052044
24	MP0001984_abnormal_olfaction	1.81848021
25	MP0008877_abnormal_DNA_methylation	1.81465282
26	MP0003122_maternal_imprinting	1.79057456
27	MP0002557_abnormal_social/conspecific_i	1.78937681
28	MP0004270_analgesia	1.77289221
29	MP0001485_abnormal_pinna_reflex	1.76805122
30	MP0004142_abnormal_muscle_tone	1.73497991
31	MP0002063_abnormal_learning/memory/cond	1.69467907
32	MP0001486_abnormal_startle_reflex	1.67865746
33	MP0002572_abnormal_emotion/affect_behav	1.67338945
34	MP0001970_abnormal_pain_threshold	1.62976366
35	MP0002184_abnormal_innervation	1.62704477
36	MP0002733_abnormal_thermal_nociception	1.62185619
37	MP0002734_abnormal_mechanical_nocicepti	1.61229080
38	MP0002064_seizures	1.60322408
39	MP0004133_heterotaxia	1.51004065
40	MP0001440_abnormal_grooming_behavior	1.50821725
41	MP0002928_abnormal_bile_duct	1.48878350
42	MP0004145_abnormal_muscle_electrophysio	1.48094512
43	MP0002882_abnormal_neuron_morphology	1.41904802
44	MP0002067_abnormal_sensory_capabilities	1.39449218
45	MP0005551_abnormal_eye_electrophysiolog	1.38859733
46	MP0002653_abnormal_ependyma_morphology	1.37937582
47	MP0004924_abnormal_behavior	1.37524029
48	MP0005386_behavior/neurological_phenoty	1.37524029
49	MP0002752_abnormal_somatic_nervous	1.33962047
50	MP0006292_abnormal_olfactory_placode	1.31980170
51	MP0001968_abnormal_touch/_nociception	1.26420419
52	MP0004811_abnormal_neuron_physiology	1.25066027
53	MP0004885_abnormal_endolymph	1.23255125
54	MP0001905_abnormal_dopamine_level	1.22567396
55	MP0005394_taste/olfaction_phenotype	1.22429265
56	MP0005499_abnormal_olfactory_system	1.22429265
57	MP0003283_abnormal_digestive_organ	1.21667969
58	MP0004134_abnormal_chest_morphology	1.21294984
59	MP0003646_muscle_fatigue	1.16383209
60	MP0000566_synostosis	1.15621725
61	MP0002735_abnormal_chemical_nociception	1.11498905
62	MP0009379_abnormal_foot_pigmentation	1.11476759
63	MP0008789_abnormal_olfactory_epithelium	1.10579615
64	MP0004043_abnormal_pH_regulation	1.10026590
65	MP0002909_abnormal_adrenal_gland	1.09553493
66	MP0000631_abnormal_neuroendocrine_gland	1.05368802
67	MP0004782_abnormal_surfactant_physiolog	1.04362261
68	MP0003119_abnormal_digestive_system	1.03769945
69	MP0002152_abnormal_brain_morphology	1.03535374
70	MP0003879_abnormal_hair_cell	1.01330427
71	MP0002229_neurodegeneration	0.93543872
72	MP0005645_abnormal_hypothalamus_physiol	0.92391826
73	MP0004130_abnormal_muscle_cell	0.92117028
74	MP0008569_lethality_at_weaning	0.91819379
75	MP0003861_abnormal_nervous_system	0.91673586
76	MP0000026_abnormal_inner_ear	0.91281904
77	MP0002066_abnormal_motor_capabilities/c	0.91063974
78	MP0002160_abnormal_reproductive_system	0.90492442
79	MP0002736_abnormal_nociception_after	0.86820260
80	MP0009053_abnormal_anal_canal	0.86375318
81	MP0005409_darkened_coat_color	0.86173504
82	MP0005195_abnormal_posterior_eye	0.85133752
83	MP0001963_abnormal_hearing_physiology	0.84836910
84	MP0005379_endocrine/exocrine_gland_phen	0.84501466
85	MP0004085_abnormal_heartbeat	0.84497861
86	MP0003385_abnormal_body_wall	0.82321203
87	MP0002837_dystrophic_cardiac_calcinosis	0.80211286
88	MP0002876_abnormal_thyroid_physiology	0.78602619
89	MP0001501_abnormal_sleep_pattern	0.75590398
90	MP0000639_abnormal_adrenal_gland	0.72939448
91	MP0000230_abnormal_systemic_arterial	0.72682662
92	MP0002638_abnormal_pupillary_reflex	0.72347687
93	MP0003942_abnormal_urinary_system	0.71656916
94	MP0001986_abnormal_taste_sensitivity	0.69604487
95	MP0005389_reproductive_system_phenotype	0.69183981
96	MP0008995_early_reproductive_senescence	0.68067817
97	MP0006072_abnormal_retinal_apoptosis	0.66376052
98	MP0001502_abnormal_circadian_rhythm	0.64348772
99	MP0001919_abnormal_reproductive_system	0.64331318
100	MP0005377_hearing/vestibular/ear_phenot	0.64195989

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Myokymia (HP:0002411)	5.62381127
2	Abnormal pancreas size (HP:0012094)	5.33077812
3	Progressive cerebellar ataxia (HP:0002073)	4.91376639
4	Genetic anticipation (HP:0003743)	4.73512240
5	Anosmia (HP:0000458)	3.41888176
6	Limb dystonia (HP:0002451)	3.39699460
7	Agitation (HP:0000713)	3.26223492
8	Urinary bladder sphincter dysfunction (HP:0002839)	3.24909120
9	Diastasis recti (HP:0001540)	3.24346313
10	Gaze-evoked nystagmus (HP:0000640)	3.08495780
11	Hepatoblastoma (HP:0002884)	3.07372437
12	Abnormality of binocular vision (HP:0011514)	2.92305406
13	Diplopia (HP:0000651)	2.92305406
14	Febrile seizures (HP:0002373)	2.92208300
15	Epileptic encephalopathy (HP:0200134)	2.91515178
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.85965516
17	Gait imbalance (HP:0002141)	2.80614512
18	Medial flaring of the eyebrow (HP:0010747)	2.76230365
19	Decreased circulating renin level (HP:0003351)	2.75974346
20	Hypogonadotrophic hypogonadism (HP:0000044)	2.71659890
21	Dysdiadochokinesis (HP:0002075)	2.70249387
22	Congenital stationary night blindness (HP:0007642)	2.69703672
23	Impaired vibration sensation in the lower limbs (HP:0002166)	2.66285993
24	Pachygyria (HP:0001302)	2.60541530
25	Abnormality of midbrain morphology (HP:0002418)	2.59323544
26	Molar tooth sign on MRI (HP:0002419)	2.59323544
27	Neonatal hypoglycemia (HP:0001998)	2.58696778
28	Growth hormone deficiency (HP:0000824)	2.55798970
29	Congenital primary aphakia (HP:0007707)	2.54774051
30	Adrenal hypoplasia (HP:0000835)	2.53495847
31	Nephrogenic diabetes insipidus (HP:0009806)	2.50560815
32	Focal seizures (HP:0007359)	2.48759428
33	Ulnar claw (HP:0001178)	2.48289276
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.47930668
35	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.43940025
36	Amblyopia (HP:0000646)	2.42656960
37	Retinal dysplasia (HP:0007973)	2.41462989
38	Rib fusion (HP:0000902)	2.38351188
39	Broad-based gait (HP:0002136)	2.37508787
40	Vaginal atresia (HP:0000148)	2.37389651
41	Lissencephaly (HP:0001339)	2.37051130
42	Chronic hepatic failure (HP:0100626)	2.36973684
43	Pancreatic fibrosis (HP:0100732)	2.36090980
44	Anomalous pulmonary venous return (HP:0010772)	2.35184359
45	Fetal akinesia sequence (HP:0001989)	2.34743246
46	Neoplasm of the adrenal cortex (HP:0100641)	2.33923244
47	Specific learning disability (HP:0001328)	2.31433427
48	Polyphagia (HP:0002591)	2.31183301
49	Absence seizures (HP:0002121)	2.26892514
50	Genital tract atresia (HP:0001827)	2.25305797
51	Atonic seizures (HP:0010819)	2.24820351
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.21829381
53	Esotropia (HP:0000565)	2.21104572
54	Nephronophthisis (HP:0000090)	2.20704107
55	Decreased central vision (HP:0007663)	2.19833922
56	Metaphyseal dysplasia (HP:0100255)	2.19094651
57	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.17944228
58	Hypoplasia of the brainstem (HP:0002365)	2.17944228
59	Impaired smooth pursuit (HP:0007772)	2.15933329
60	Abnormality of the corticospinal tract (HP:0002492)	2.14237892
61	Acute necrotizing encephalopathy (HP:0006965)	2.07152285
62	Abnormality of the pulmonary veins (HP:0011718)	2.07020081
63	Abnormality of the renal medulla (HP:0100957)	2.05778493
64	Hemiparesis (HP:0001269)	2.05253917
65	Sclerocornea (HP:0000647)	2.01237833
66	Shawl scrotum (HP:0000049)	2.00831634
67	Dialeptic seizures (HP:0011146)	2.00646481
68	Osteomalacia (HP:0002749)	1.99918927
69	Chronic bronchitis (HP:0004469)	1.99172110
70	Retinitis pigmentosa (HP:0000510)	1.96915920
71	Dyskinesia (HP:0100660)	1.96842705
72	Failure to thrive in infancy (HP:0001531)	1.96340276
73	Abnormality of the aortic arch (HP:0012303)	1.93047834
74	Focal motor seizures (HP:0011153)	1.92234813
75	Asplenia (HP:0001746)	1.92043903
76	True hermaphroditism (HP:0010459)	1.91587550
77	Dysmetria (HP:0001310)	1.90817699
78	Stenosis of the external auditory canal (HP:0000402)	1.90516426
79	Poor coordination (HP:0002370)	1.90301505
80	Left ventricular hypertrophy (HP:0001712)	1.89977545
81	Pendular nystagmus (HP:0012043)	1.89308779
82	Spastic tetraplegia (HP:0002510)	1.86444191
83	Myotonia (HP:0002486)	1.85689055
84	Absent eyebrow (HP:0002223)	1.83471934
85	Acute encephalopathy (HP:0006846)	1.83173311
86	Restlessness (HP:0000711)	1.82308048
87	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.82096747
88	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.82096747
89	Thyroid-stimulating hormone excess (HP:0002925)	1.81387323
90	Drooling (HP:0002307)	1.80512430
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.79474106
92	Enlarged kidneys (HP:0000105)	1.79142502
93	Tubular atrophy (HP:0000092)	1.78673031
94	Optic nerve hypoplasia (HP:0000609)	1.78308469
95	Polydipsia (HP:0001959)	1.77005494
96	Abnormal drinking behavior (HP:0030082)	1.77005494
97	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.76533515
98	Impaired vibratory sensation (HP:0002495)	1.76239971
99	Mitochondrial inheritance (HP:0001427)	1.75821103
100	Pancreatic cysts (HP:0001737)	1.75246280

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	SIK2	5.59704258
2	TNIK	5.52880748
3	MINK1	3.81444317
4	MARK1	3.63398993
5	CASK	3.39969465
6	NTRK3	3.04298427
7	WNK4	2.90607556
8	NTRK2	2.48976103
9	FRK	2.27062164
10	EPHB2	2.19004084
11	MAP3K9	2.17732496
12	DYRK2	2.10596522
13	PINK1	2.03246130
14	TYRO3	1.99328042
15	EPHA4	1.60469421
16	MAP2K7	1.54562280
17	WNK3	1.54317153
18	PRKCG	1.50580533
19	PAK3	1.44898406
20	WNK1	1.40654154
21	GRK1	1.35071234
22	MAP3K4	1.29373105
23	SGK494	1.27591781
24	SGK223	1.27591781
25	BCR	1.23419044
26	PNCK	1.23131041
27	CSNK1G2	1.21795338
28	CDK5	1.17558677
29	ADRBK2	1.17423418
30	STK39	1.14388904
31	NLK	1.11271163
32	PRKCH	1.11090824
33	RPS6KA2	1.10852830
34	MARK2	1.05490111
35	MAPK13	1.02598126
36	STK11	1.00525951
37	ARAF	0.98891167
38	TAOK3	0.93188098
39	SGK2	0.87136565
40	MAPK15	0.82886054
41	NEK2	0.80988883
42	PTK6	0.79836643
43	INSRR	0.79182003
44	CSNK1E	0.79151448
45	CAMKK1	0.77608177
46	SIK3	0.76878331
47	DMPK	0.76593219
48	LIMK1	0.76255616
49	MAP2K4	0.75659740
50	CAMK1D	0.70243694
51	BMPR1B	0.69127827
52	DYRK3	0.68282926
53	BRAF	0.68224186
54	MAP3K11	0.63734285
55	RPS6KA6	0.62466401
56	PRKACA	0.59797013
57	PRKCZ	0.58994042
58	CSNK1A1	0.57898881
59	CAMK1G	0.57229233
60	DYRK1B	0.56995475
61	ERBB2	0.56501510
62	TNK2	0.56486223
63	DYRK1A	0.55427604
64	OXSR1	0.52090219
65	MAPK4	0.51442061
66	CAMK2A	0.49865959
67	MARK3	0.48862430
68	MUSK	0.48571892
69	SGK3	0.48022139
70	RPS6KL1	0.47611199
71	RPS6KC1	0.47611199
72	LMTK2	0.46712541
73	NTRK1	0.46074346
74	CSNK1G3	0.45747666
75	IRAK1	0.44957602
76	SGK1	0.44079328
77	PIM2	0.43724664
78	MAPK8	0.43640207
79	PRKCQ	0.39615233
80	PRKCE	0.38485599
81	CSNK1A1L	0.38257036
82	CSNK1G1	0.37831406
83	DAPK2	0.37830865
84	PRKD3	0.36838264
85	PRKCA	0.36649669
86	ADRBK1	0.36536937
87	PRKG1	0.36253112
88	CDK14	0.35527223
89	STK38	0.35179877
90	SIK1	0.32619983
91	ITK	0.32076439
92	RPS6KA3	0.30509689
93	GSK3B	0.29719209
94	TAOK1	0.29280950
95	PIK3CA	0.28383373
96	CAMK1	0.28011815
97	MAPK9	0.28007208
98	CAMKK2	0.27300476
99	PRKCI	0.27051102
100	AKT1	0.25933986

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.79406965
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.05069813
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.92610610
4	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.83193180
5	Parkinsons disease_Homo sapiens_hsa05012	2.61127343
6	Phototransduction_Homo sapiens_hsa04744	2.60457273
7	GABAergic synapse_Homo sapiens_hsa04727	2.51844771
8	Morphine addiction_Homo sapiens_hsa05032	2.50737180
9	Glutamatergic synapse_Homo sapiens_hsa04724	2.46184134
10	Dopaminergic synapse_Homo sapiens_hsa04728	2.24439673
11	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.15538641
12	Alzheimers disease_Homo sapiens_hsa05010	2.03540998
13	Taste transduction_Homo sapiens_hsa04742	2.02852606
14	Long-term depression_Homo sapiens_hsa04730	2.01796065
15	Insulin secretion_Homo sapiens_hsa04911	1.77379028
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.76333974
17	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.75983648
18	Circadian entrainment_Homo sapiens_hsa04713	1.75639966
19	Huntingtons disease_Homo sapiens_hsa05016	1.74743140
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71399751
21	Serotonergic synapse_Homo sapiens_hsa04726	1.70112923
22	Axon guidance_Homo sapiens_hsa04360	1.69527500
23	Cholinergic synapse_Homo sapiens_hsa04725	1.66771053
24	Cocaine addiction_Homo sapiens_hsa05030	1.66445547
25	Ribosome_Homo sapiens_hsa03010	1.60791126
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.56814289
27	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.54558529
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.48376209
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.37861623
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25397550
31	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.24535537
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24195025
33	Olfactory transduction_Homo sapiens_hsa04740	1.23270241
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22641865
35	Amphetamine addiction_Homo sapiens_hsa05031	1.22079251
36	Basal cell carcinoma_Homo sapiens_hsa05217	1.16665787
37	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.15930419
38	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.12410556
39	Regulation of autophagy_Homo sapiens_hsa04140	1.09750081
40	Long-term potentiation_Homo sapiens_hsa04720	1.06613218
41	Gap junction_Homo sapiens_hsa04540	1.03196137
42	Calcium signaling pathway_Homo sapiens_hsa04020	0.98175678
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.95686152
44	Gastric acid secretion_Homo sapiens_hsa04971	0.95161774
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.95016302
46	MAPK signaling pathway_Homo sapiens_hsa04010	0.93209304
47	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.88882191
48	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.84883730
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.82480626
50	Ras signaling pathway_Homo sapiens_hsa04014	0.82088922
51	Melanogenesis_Homo sapiens_hsa04916	0.82080918
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81598526
53	cAMP signaling pathway_Homo sapiens_hsa04024	0.78977159
54	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.74462739
55	Estrogen signaling pathway_Homo sapiens_hsa04915	0.74166136
56	Renin secretion_Homo sapiens_hsa04924	0.74145072
57	Salivary secretion_Homo sapiens_hsa04970	0.74088350
58	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.70525513
59	Wnt signaling pathway_Homo sapiens_hsa04310	0.70127830
60	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.69948279
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.68369797
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.67335903
63	Bile secretion_Homo sapiens_hsa04976	0.66325416
64	Retinol metabolism_Homo sapiens_hsa00830	0.60963265
65	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.57057809
66	Hippo signaling pathway_Homo sapiens_hsa04390	0.56130584
67	Rap1 signaling pathway_Homo sapiens_hsa04015	0.55882635
68	Alcoholism_Homo sapiens_hsa05034	0.55742222
69	Caffeine metabolism_Homo sapiens_hsa00232	0.55500945
70	ErbB signaling pathway_Homo sapiens_hsa04012	0.54857282
71	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.54574289
72	Butanoate metabolism_Homo sapiens_hsa00650	0.53810048
73	Type II diabetes mellitus_Homo sapiens_hsa04930	0.53697089
74	Ether lipid metabolism_Homo sapiens_hsa00565	0.53496814
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53114675
76	GnRH signaling pathway_Homo sapiens_hsa04912	0.52109809
77	Peroxisome_Homo sapiens_hsa04146	0.49979433
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.49906109
79	Pancreatic secretion_Homo sapiens_hsa04972	0.48634568
80	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.48049240
81	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.47313995
82	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.46860880
83	Melanoma_Homo sapiens_hsa05218	0.46824316
84	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.45386700
85	Notch signaling pathway_Homo sapiens_hsa04330	0.43944956
86	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40836281
87	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.40045525
88	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.39286667
89	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.39215797
90	Vibrio cholerae infection_Homo sapiens_hsa05110	0.37509750
91	Sulfur relay system_Homo sapiens_hsa04122	0.35270872
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34674997
93	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.34223947
94	VEGF signaling pathway_Homo sapiens_hsa04370	0.32232629
95	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29694418
96	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.29096158
97	Selenocompound metabolism_Homo sapiens_hsa00450	0.28788889
98	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.27592251
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.25087438
100	ABC transporters_Homo sapiens_hsa02010	0.23207388

NEFMP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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