NEGR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95040502
2vocalization behavior (GO:0071625)5.61445135
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.51323704
4locomotory exploration behavior (GO:0035641)5.50460090
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.39239444
6synaptic vesicle exocytosis (GO:0016079)5.33630333
7synaptic vesicle maturation (GO:0016188)5.29546430
8neuron cell-cell adhesion (GO:0007158)5.29546023
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.15755903
10protein localization to synapse (GO:0035418)5.06944990
11regulation of glutamate receptor signaling pathway (GO:1900449)4.95489570
12glutamate secretion (GO:0014047)4.91792875
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.78852509
14regulation of synaptic vesicle exocytosis (GO:2000300)4.76581662
15behavioral response to nicotine (GO:0035095)4.72250370
16exploration behavior (GO:0035640)4.63977861
17glutamate receptor signaling pathway (GO:0007215)4.51052745
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.50111328
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48378384
20neuronal action potential propagation (GO:0019227)4.42222276
21neurotransmitter-gated ion channel clustering (GO:0072578)4.39706476
22layer formation in cerebral cortex (GO:0021819)4.38540924
23synaptic transmission, glutamatergic (GO:0035249)4.32652418
24serotonin metabolic process (GO:0042428)4.29214000
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.24339349
26neurotransmitter secretion (GO:0007269)4.22918631
27regulation of synaptic vesicle transport (GO:1902803)4.20258632
28neuron-neuron synaptic transmission (GO:0007270)4.17423324
29dendritic spine morphogenesis (GO:0060997)4.13304888
30regulation of neuronal synaptic plasticity (GO:0048168)4.05216130
31presynaptic membrane assembly (GO:0097105)4.02105908
32neuron recognition (GO:0008038)4.01629264
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.99780209
34postsynaptic membrane organization (GO:0001941)3.98288258
35gamma-aminobutyric acid transport (GO:0015812)3.94229880
36regulation of synapse structural plasticity (GO:0051823)3.90755295
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.87486435
38gamma-aminobutyric acid signaling pathway (GO:0007214)3.86078209
39primary amino compound metabolic process (GO:1901160)3.81864093
40G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.80435251
41response to histamine (GO:0034776)3.77037443
42positive regulation of synapse maturation (GO:0090129)3.76191938
43axonal fasciculation (GO:0007413)3.76012211
44long-term memory (GO:0007616)3.75648255
45regulation of postsynaptic membrane potential (GO:0060078)3.73316269
46positive regulation of membrane potential (GO:0045838)3.73241349
47proline transport (GO:0015824)3.70983788
48cerebellar granule cell differentiation (GO:0021707)3.70823970
49presynaptic membrane organization (GO:0097090)3.69206998
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.62668870
51cellular potassium ion homeostasis (GO:0030007)3.60639705
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.52985544
53neurotransmitter transport (GO:0006836)3.52517513
54transmission of nerve impulse (GO:0019226)3.46391195
55long-term synaptic potentiation (GO:0060291)3.44663947
56positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42957566
57regulation of dendritic spine morphogenesis (GO:0061001)3.42850657
58dendrite morphogenesis (GO:0048813)3.41624125
59regulation of synaptic plasticity (GO:0048167)3.39191596
60synaptic vesicle endocytosis (GO:0048488)3.38394674
61auditory behavior (GO:0031223)3.37898522
62positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.36991235
63regulation of neurotransmitter secretion (GO:0046928)3.35282120
64activation of protein kinase A activity (GO:0034199)3.33987754
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33426949
66synapse assembly (GO:0007416)3.32474107
67negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31140012
68regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30070662
69cerebellar Purkinje cell differentiation (GO:0021702)3.28758862
70positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26649021
71neuronal action potential (GO:0019228)3.24500042
72membrane hyperpolarization (GO:0060081)3.23671075
73pyrimidine nucleobase catabolic process (GO:0006208)3.21490744
74regulation of neurotransmitter levels (GO:0001505)3.21133419
75regulation of vesicle fusion (GO:0031338)3.19586805
76behavioral fear response (GO:0001662)3.19551495
77behavioral defense response (GO:0002209)3.19551495
78response to auditory stimulus (GO:0010996)3.18701727
79innervation (GO:0060384)3.16343377
80membrane depolarization (GO:0051899)3.15687333
81regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14932815
82startle response (GO:0001964)3.14665898
83negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12970046
84positive regulation of neurotransmitter secretion (GO:0001956)3.11453261
85neuromuscular process controlling balance (GO:0050885)3.10023390
86regulation of neurotransmitter transport (GO:0051588)3.07463931
87fear response (GO:0042596)3.06115518
88learning (GO:0007612)3.05801195
89regulation of dendritic spine development (GO:0060998)3.05522618
90central nervous system projection neuron axonogenesis (GO:0021952)3.04807741
91righting reflex (GO:0060013)3.02725016
92intraspecies interaction between organisms (GO:0051703)3.01929749
93social behavior (GO:0035176)3.01929749
94positive regulation of synapse assembly (GO:0051965)3.00735632
95sodium ion export (GO:0071436)2.99760097
96prepulse inhibition (GO:0060134)2.98954652
97membrane depolarization during action potential (GO:0086010)2.98680977
98synapse organization (GO:0050808)2.98545033
99regulation of synapse maturation (GO:0090128)2.97998450
100positive regulation of dendritic spine development (GO:0060999)2.97693057
101positive regulation of neurotransmitter transport (GO:0051590)2.97344852
102mechanosensory behavior (GO:0007638)2.95334341
103potassium ion homeostasis (GO:0055075)2.95313018
104potassium ion import (GO:0010107)2.94109146
105synaptic transmission (GO:0007268)2.93830874
106positive regulation of synaptic transmission (GO:0050806)2.93059817
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.90967952
108regulation of synaptic transmission (GO:0050804)2.90538870
109negative regulation of response to food (GO:0032096)2.89007073
110negative regulation of appetite (GO:0032099)2.89007073
111neuromuscular synaptic transmission (GO:0007274)2.88719277
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86239027
113behavioral response to cocaine (GO:0048148)2.85311111
114adult walking behavior (GO:0007628)2.83735225
115regulation of voltage-gated calcium channel activity (GO:1901385)2.75305758
116nucleobase catabolic process (GO:0046113)2.75286818
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73804926
118positive regulation of potassium ion transmembrane transport (GO:1901381)2.71052024
119action potential (GO:0001508)2.70974042
120reflex (GO:0060004)2.69757093
121central nervous system myelination (GO:0022010)2.68189099
122axon ensheathment in central nervous system (GO:0032291)2.68189099
123regulation of respiratory system process (GO:0044065)2.67777803
124indole-containing compound metabolic process (GO:0042430)2.67384397
125adult behavior (GO:0030534)2.65462588
126glycosphingolipid biosynthetic process (GO:0006688)2.65461190
127regulation of membrane repolarization (GO:0060306)2.65030432
128cellular potassium ion transport (GO:0071804)2.63244032
129potassium ion transmembrane transport (GO:0071805)2.63244032
130cAMP catabolic process (GO:0006198)2.62431890
131urinary tract smooth muscle contraction (GO:0014848)2.59325848
132regulation of cell communication by electrical coupling (GO:0010649)2.59057756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.97011007
2GBX2_23144817_ChIP-Seq_PC3_Human3.93669281
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12809471
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01319700
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.00963949
6REST_21632747_ChIP-Seq_MESCs_Mouse2.65203124
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61066070
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61066070
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58125380
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54788392
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.54600061
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51271287
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44647525
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43587535
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41097612
16* EED_16625203_ChIP-ChIP_MESCs_Mouse2.29158379
17* DROSHA_22980978_ChIP-Seq_HELA_Human2.27566850
18* RARB_27405468_Chip-Seq_BRAIN_Mouse2.25762257
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25056889
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.18423806
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16630710
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15055993
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.12813181
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.10475646
25* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06492396
26TAF15_26573619_Chip-Seq_HEK293_Human2.05897477
27AR_21572438_ChIP-Seq_LNCaP_Human2.05515323
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.04015240
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93218393
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92214048
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.79978836
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77417273
33* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77121263
34SMAD4_21799915_ChIP-Seq_A2780_Human1.75659794
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64389611
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.61330145
37P300_19829295_ChIP-Seq_ESCs_Human1.57522116
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55645003
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51840489
40ZNF274_21170338_ChIP-Seq_K562_Hela1.47760849
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47542755
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.46100592
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44961979
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.44896358
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42679541
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.40635454
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39710402
48* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38388373
49* SOX2_21211035_ChIP-Seq_LN229_Gbm1.37898875
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.36895904
51AR_25329375_ChIP-Seq_VCAP_Human1.36423932
52IGF1R_20145208_ChIP-Seq_DFB_Human1.35666679
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35529282
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34742766
55* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34239498
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.33789325
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33415466
58STAT3_23295773_ChIP-Seq_U87_Human1.33214011
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33033088
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33030208
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.32990174
62* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31728923
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.30658734
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28806493
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27642410
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.27241464
67FUS_26573619_Chip-Seq_HEK293_Human1.26639832
68RNF2_27304074_Chip-Seq_NSC_Mouse1.24392522
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24117071
70EWS_26573619_Chip-Seq_HEK293_Human1.21690928
71* AR_19668381_ChIP-Seq_PC3_Human1.20482010
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19721430
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17572694
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.16674314
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.16177787
76* TCF4_23295773_ChIP-Seq_U87_Human1.15102191
77CBP_20019798_ChIP-Seq_JUKART_Human1.14808572
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14808572
79* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14004179
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12921109
81RING1B_27294783_Chip-Seq_NPCs_Mouse1.10725911
82AHR_22903824_ChIP-Seq_MCF-7_Human1.09594530
83* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09458918
84RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09345761
85* KDM2B_26808549_Chip-Seq_REH_Human1.09246139
86* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06810220
87TP53_16413492_ChIP-PET_HCT116_Human1.06695097
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.06582554
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05852622
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04923201
91TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04923201
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04713871
93ER_23166858_ChIP-Seq_MCF-7_Human1.04653571
94KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04586843
95* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.04015567
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02691089
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.02094039
98MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01490471
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00970575
100RXR_22108803_ChIP-Seq_LS180_Human1.00900079
101VDR_22108803_ChIP-Seq_LS180_Human1.00455545
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.00414941
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99569280
104* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98111685
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.96264687
106JUN_21703547_ChIP-Seq_K562_Human0.94766192
107* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94116911
108BCAT_22108803_ChIP-Seq_LS180_Human0.94060662
109* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93170021
110* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91128878
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.90920419
112* TP53_18474530_ChIP-ChIP_U2OS_Human0.90787307
113* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89829850
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.87740549
115WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85279663
116TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85195660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.92442917
2MP0003880_abnormal_central_pattern4.87381040
3MP0003635_abnormal_synaptic_transmissio4.13841645
4MP0004270_analgesia3.66695198
5MP0009745_abnormal_behavioral_response3.41397763
6MP0002063_abnormal_learning/memory/cond3.33861095
7MP0009046_muscle_twitch3.18694837
8MP0002064_seizures3.14266027
9MP0005423_abnormal_somatic_nervous3.06313005
10MP0001968_abnormal_touch/_nociception3.03029240
11MP0002572_abnormal_emotion/affect_behav2.88472806
12MP0002734_abnormal_mechanical_nocicepti2.66226436
13MP0001486_abnormal_startle_reflex2.63851880
14MP0002272_abnormal_nervous_system2.59526544
15MP0003646_muscle_fatigue2.26615132
16MP0001501_abnormal_sleep_pattern2.26329072
17MP0001440_abnormal_grooming_behavior2.26091644
18MP0002736_abnormal_nociception_after2.25760142
19MP0002822_catalepsy2.15853309
20MP0002735_abnormal_chemical_nociception2.14073305
21MP0002067_abnormal_sensory_capabilities2.10964437
22MP0000778_abnormal_nervous_system2.07024452
23MP0002733_abnormal_thermal_nociception2.01609420
24MP0002184_abnormal_innervation1.97924518
25MP0009780_abnormal_chondrocyte_physiolo1.94266305
26MP0001970_abnormal_pain_threshold1.89479488
27MP0008569_lethality_at_weaning1.88591656
28MP0005386_behavior/neurological_phenoty1.86265299
29MP0004924_abnormal_behavior1.86265299
30MP0002557_abnormal_social/conspecific_i1.82968675
31MP0003329_amyloid_beta_deposits1.80204537
32MP0004130_abnormal_muscle_cell1.78899828
33MP0006276_abnormal_autonomic_nervous1.76585592
34MP0001984_abnormal_olfaction1.72430368
35MP0004811_abnormal_neuron_physiology1.65349457
36MP0002909_abnormal_adrenal_gland1.61336026
37MP0005646_abnormal_pituitary_gland1.60428056
38MP0003879_abnormal_hair_cell1.59532537
39MP0000955_abnormal_spinal_cord1.55503682
40MP0001529_abnormal_vocalization1.52339147
41MP0002882_abnormal_neuron_morphology1.49136491
42MP0004885_abnormal_endolymph1.47878049
43MP0005645_abnormal_hypothalamus_physiol1.46755176
44MP0002066_abnormal_motor_capabilities/c1.45274039
45MP0004858_abnormal_nervous_system1.40470678
46MP0005551_abnormal_eye_electrophysiolog1.39837874
47MP0004142_abnormal_muscle_tone1.36307201
48MP0001502_abnormal_circadian_rhythm1.36272991
49MP0001188_hyperpigmentation1.31315489
50MP0003787_abnormal_imprinting1.31085187
51MP0003122_maternal_imprinting1.29823498
52MP0003633_abnormal_nervous_system1.28850829
53MP0001905_abnormal_dopamine_level1.22398005
54MP0002152_abnormal_brain_morphology1.18744927
55MP0004742_abnormal_vestibular_system1.15920810
56MP0004133_heterotaxia1.14778017
57MP0002102_abnormal_ear_morphology1.14062939
58MP0002160_abnormal_reproductive_system1.13757363
59MP0000569_abnormal_digit_pigmentation1.11889169
60MP0003631_nervous_system_phenotype1.10935581
61MP0004145_abnormal_muscle_electrophysio1.10366464
62MP0003121_genomic_imprinting1.09432083
63MP0002229_neurodegeneration1.04836928
64MP0008877_abnormal_DNA_methylation1.04357420
65MP0000631_abnormal_neuroendocrine_gland0.98931553
66MP0002837_dystrophic_cardiac_calcinosis0.98240339
67MP0002069_abnormal_eating/drinking_beha0.94353422
68MP0003634_abnormal_glial_cell0.90876926
69MP0001963_abnormal_hearing_physiology0.89482633
70MP0000751_myopathy0.88627028
71MP0002752_abnormal_somatic_nervous0.88556839
72MP0010386_abnormal_urinary_bladder0.88269915
73MP0008872_abnormal_physiological_respon0.87469090
74MP0006072_abnormal_retinal_apoptosis0.86818254
75MP0000013_abnormal_adipose_tissue0.86536890
76MP0004085_abnormal_heartbeat0.86505938
77MP0005499_abnormal_olfactory_system0.85822241
78MP0005394_taste/olfaction_phenotype0.85822241
79MP0002090_abnormal_vision0.85697889
80MP0004215_abnormal_myocardial_fiber0.84104883
81MP0003632_abnormal_nervous_system0.82902355
82MP0008775_abnormal_heart_ventricle0.82623714
83MP0000049_abnormal_middle_ear0.81371173
84MP0003690_abnormal_glial_cell0.81142925
85MP0000230_abnormal_systemic_arterial0.81108708
86MP0001177_atelectasis0.80400367
87MP0005535_abnormal_body_temperature0.79691042
88MP0002876_abnormal_thyroid_physiology0.79675564
89MP0003283_abnormal_digestive_organ0.78575081
90MP0008874_decreased_physiological_sensi0.76858337
91MP0000920_abnormal_myelination0.76303743
92MP0002928_abnormal_bile_duct0.75520849
93MP0005409_darkened_coat_color0.74501220
94MP0000604_amyloidosis0.74026852
95MP0003137_abnormal_impulse_conducting0.73810072
96MP0004147_increased_porphyrin_level0.71428406
97MP0003890_abnormal_embryonic-extraembry0.71388064
98MP0001986_abnormal_taste_sensitivity0.70746606
99MP0005253_abnormal_eye_physiology0.69918262
100MP0005389_reproductive_system_phenotype0.69334914
101MP0003119_abnormal_digestive_system0.68250533
102MP0004233_abnormal_muscle_weight0.67933574
103MP0002638_abnormal_pupillary_reflex0.66224682
104MP0001485_abnormal_pinna_reflex0.65974928
105MP0004484_altered_response_of0.65253187
106MP0008961_abnormal_basal_metabolism0.64561699
107MP0003861_abnormal_nervous_system0.63669084
108MP0005670_abnormal_white_adipose0.63202655
109MP0002653_abnormal_ependyma_morphology0.62042876
110MP0000026_abnormal_inner_ear0.61318787
111MP0000427_abnormal_hair_cycle0.60934847
112MP0005195_abnormal_posterior_eye0.60247685
113MP0001299_abnormal_eye_distance/0.60158298
114MP0002234_abnormal_pharynx_morphology0.59240818
115MP0001943_abnormal_respiration0.59085841
116MP0005174_abnormal_tail_pigmentation0.57864719
117MP0005187_abnormal_penis_morphology0.57546825
118MP0001879_abnormal_lymphatic_vessel0.56804994
119MP0004043_abnormal_pH_regulation0.56511112
120MP0001664_abnormal_digestion0.56447954
121MP0002082_postnatal_lethality0.56313173
122MP0010770_preweaning_lethality0.56313173
123MP0010769_abnormal_survival0.56282892
124MP0003937_abnormal_limbs/digits/tail_de0.55796241

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.44240762
2Myokymia (HP:0002411)5.78515355
3Focal seizures (HP:0007359)5.66719464
4Epileptic encephalopathy (HP:0200134)5.29822913
5Visual hallucinations (HP:0002367)5.09356865
6Atonic seizures (HP:0010819)4.65732293
7Febrile seizures (HP:0002373)4.40304843
8Absence seizures (HP:0002121)4.37911623
9Progressive cerebellar ataxia (HP:0002073)4.31935473
10Broad-based gait (HP:0002136)4.07654675
11Hyperventilation (HP:0002883)4.04021404
12Dialeptic seizures (HP:0011146)3.99847279
13Generalized tonic-clonic seizures (HP:0002069)3.87935120
14Action tremor (HP:0002345)3.61698790
15Poor eye contact (HP:0000817)3.46753589
16Gaze-evoked nystagmus (HP:0000640)3.37769027
17Supranuclear gaze palsy (HP:0000605)3.32302113
18Drooling (HP:0002307)3.21800274
19Excessive salivation (HP:0003781)3.21800274
20Truncal ataxia (HP:0002078)3.19360643
21Mutism (HP:0002300)3.17496560
22Dysdiadochokinesis (HP:0002075)3.16505149
23Abnormal social behavior (HP:0012433)3.11845267
24Impaired social interactions (HP:0000735)3.11845267
25Ankle clonus (HP:0011448)3.07090180
26Pancreatic cysts (HP:0001737)3.02762910
27Papilledema (HP:0001085)2.96065149
28Impaired vibration sensation in the lower limbs (HP:0002166)2.93331486
29Depression (HP:0000716)2.92932953
30Abnormal eating behavior (HP:0100738)2.90868217
31Dysmetria (HP:0001310)2.86257097
32Amblyopia (HP:0000646)2.84468215
33Epileptiform EEG discharges (HP:0011182)2.82730875
34Urinary bladder sphincter dysfunction (HP:0002839)2.80163862
35Hemiparesis (HP:0001269)2.78293483
36Neurofibrillary tangles (HP:0002185)2.77962658
37Cerebral inclusion bodies (HP:0100314)2.75745167
38Anxiety (HP:0000739)2.75582096
39Nephronophthisis (HP:0000090)2.73165340
40EEG with generalized epileptiform discharges (HP:0011198)2.72559989
41Abnormality of binocular vision (HP:0011514)2.71256868
42Diplopia (HP:0000651)2.71256868
43Genetic anticipation (HP:0003743)2.70606415
44Scanning speech (HP:0002168)2.67558584
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.64751048
46Polyphagia (HP:0002591)2.60507826
47Absent speech (HP:0001344)2.59848010
48Postural instability (HP:0002172)2.59254573
49Impaired smooth pursuit (HP:0007772)2.58284210
50Abnormality of the corticospinal tract (HP:0002492)2.56420065
51Pancreatic fibrosis (HP:0100732)2.55453104
52Hypsarrhythmia (HP:0002521)2.55286546
53True hermaphroditism (HP:0010459)2.52103743
54Progressive inability to walk (HP:0002505)2.51858476
55Stereotypic behavior (HP:0000733)2.50643984
56Spastic gait (HP:0002064)2.46601814
57Congenital stationary night blindness (HP:0007642)2.44446923
58Inability to walk (HP:0002540)2.40973066
59Amyotrophic lateral sclerosis (HP:0007354)2.40911578
60Termporal pattern (HP:0011008)2.40112483
61Insidious onset (HP:0003587)2.40112483
62Limb dystonia (HP:0002451)2.39244023
63Urinary urgency (HP:0000012)2.37250034
64Protruding tongue (HP:0010808)2.35767451
65Torticollis (HP:0000473)2.35466610
66Fetal akinesia sequence (HP:0001989)2.34733159
67Abnormality of midbrain morphology (HP:0002418)2.34621505
68Molar tooth sign on MRI (HP:0002419)2.34621505
69Gait imbalance (HP:0002141)2.33151055
70Medial flaring of the eyebrow (HP:0010747)2.30774576
71Increased corneal curvature (HP:0100692)2.29660561
72Keratoconus (HP:0000563)2.29660561
73Dysmetric saccades (HP:0000641)2.27680974
74Abnormality of ocular smooth pursuit (HP:0000617)2.27666961
75Megalencephaly (HP:0001355)2.27053885
76Intention tremor (HP:0002080)2.27040294
77Abnormality of the renal medulla (HP:0100957)2.26247891
78Status epilepticus (HP:0002133)2.24660250
79Bradykinesia (HP:0002067)2.22616426
80Abolished electroretinogram (ERG) (HP:0000550)2.21644864
81Agitation (HP:0000713)2.20724843
82Generalized myoclonic seizures (HP:0002123)2.20697725
83Hemiplegia (HP:0002301)2.19459091
84Blue irides (HP:0000635)2.19201688
85Inappropriate behavior (HP:0000719)2.17779887
86Pheochromocytoma (HP:0002666)2.13985614
87Focal dystonia (HP:0004373)2.13015831
88Abnormality of salivation (HP:0100755)2.11389669
89Akinesia (HP:0002304)2.10619834
90Abnormality of the lower motor neuron (HP:0002366)2.10434355
91Lower limb muscle weakness (HP:0007340)2.03356845
92Decreased central vision (HP:0007663)2.03055267
93Cystic liver disease (HP:0006706)2.02393468
94Impaired vibratory sensation (HP:0002495)2.01878248
95Obstructive sleep apnea (HP:0002870)2.01623333
96Furrowed tongue (HP:0000221)1.96427686
97Congenital sensorineural hearing impairment (HP:0008527)1.96297022
98Meningioma (HP:0002858)1.95036287
99Pendular nystagmus (HP:0012043)1.93713538
100Short tibia (HP:0005736)1.93548130
101Specific learning disability (HP:0001328)1.93194427
102Thyroid-stimulating hormone excess (HP:0002925)1.91996071
103Gait ataxia (HP:0002066)1.91016434
104Craniofacial dystonia (HP:0012179)1.90973116
105Type II lissencephaly (HP:0007260)1.90515870
106Morphological abnormality of the pyramidal tract (HP:0002062)1.90001405
107Nephrogenic diabetes insipidus (HP:0009806)1.88233780
108Symphalangism affecting the phalanges of the hand (HP:0009773)1.88126293
109Genital tract atresia (HP:0001827)1.86608661
110Decreased circulating renin level (HP:0003351)1.86029898
111Neuronal loss in central nervous system (HP:0002529)1.85809377
112Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.84342343
113Short 4th metacarpal (HP:0010044)1.84342343
114Psychosis (HP:0000709)1.83092939
115Vaginal atresia (HP:0000148)1.82869813
116Neuroendocrine neoplasm (HP:0100634)1.81261897
117Prolonged QT interval (HP:0001657)1.79765663
118Incomplete penetrance (HP:0003829)1.79455582
119Attenuation of retinal blood vessels (HP:0007843)1.79060786
120Morphological abnormality of the middle ear (HP:0008609)1.77475890
121Sleep apnea (HP:0010535)1.77468453
122Generalized hypopigmentation of hair (HP:0011358)1.76746099
123Bony spicule pigmentary retinopathy (HP:0007737)1.76218090
124Lissencephaly (HP:0001339)1.74268107
125Widely spaced teeth (HP:0000687)1.74078182
126Clumsiness (HP:0002312)1.73416952
127Congenital primary aphakia (HP:0007707)1.72476147
128Exotropia (HP:0000577)1.72211263
129Syncope (HP:0001279)1.72154499
130Short foot (HP:0001773)1.71695824
131Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71659294
132Degeneration of the lateral corticospinal tracts (HP:0002314)1.71659294
133Small hand (HP:0200055)1.70871646
134Pachygyria (HP:0001302)1.70740532
135Esotropia (HP:0000565)1.69860500
136Hamartoma of the eye (HP:0010568)1.69612711
137Hyperthyroidism (HP:0000836)1.68548089
138Clonus (HP:0002169)1.67983840
139Aqueductal stenosis (HP:0002410)1.67423509
140Abnormal EKG (HP:0003115)1.67075569
141Abnormality of saccadic eye movements (HP:0000570)1.66316689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.68396235
2NTRK34.34883027
3MARK14.24096684
4EPHA43.71859857
5MAP3K93.60682717
6MAP3K43.05817161
7CASK2.89556721
8MAP2K72.64545725
9MINK12.53825032
10NTRK22.44537643
11DAPK22.41444787
12TNIK2.19064730
13PAK61.99300193
14MAP3K121.96759703
15KSR11.85780867
16MAP2K41.85201948
17MAPK131.74583033
18PNCK1.71704851
19NTRK11.68416563
20ADRBK21.66754397
21KSR21.65757775
22TLK11.64626849
23PLK21.58795562
24DAPK11.55217664
25CAMKK11.52604139
26CDK191.51012096
27PRPF4B1.49481227
28CDK51.49478880
29SIK21.48505473
30RIPK41.45138052
31BMPR1B1.38172342
32PHKG21.34396869
33PHKG11.34396869
34CAMKK21.32741420
35INSRR1.30002628
36GRK51.29316833
37GRK11.23891851
38PRKCG1.20162351
39PRKD31.19827077
40UHMK11.11006247
41CCNB11.05970971
42CAMK2A1.05883311
43ARAF1.00127353
44FES0.98580995
45MAP3K20.97158011
46OXSR10.96939544
47STK380.95548304
48LATS20.93017192
49SGK2230.91888498
50SGK4940.91888498
51ADRBK10.89268331
52CDK180.88769962
53MAP4K20.88140381
54MAP3K130.85732980
55WNK40.85409608
56CDK140.85011527
57CDK150.84938574
58STK110.84017555
59ACVR1B0.84015473
60CSNK1G20.83850925
61CAMK2B0.83651560
62CSNK1A1L0.83314386
63DYRK1A0.81854656
64SGK20.81424488
65TYRO30.81132529
66CAMK10.80017737
67PAK30.76769298
68CDK11A0.73618934
69CAMK1G0.72792468
70SGK10.72786843
71MARK20.68920038
72STK390.67466868
73TAOK10.67116425
74TAOK30.66582584
75RET0.65598040
76CSNK1G30.65127047
77PRKCH0.63747214
78PRKD20.63112692
79RAF10.63036968
80BCR0.61244687
81BMPR20.60634357
82SIK30.60602823
83SGK30.59976493
84PRKCE0.59117529
85PRKACA0.56465812
86PKN10.55498677
87CSNK1G10.55157284
88WNK30.54824216
89PRKCZ0.54662240
90PTK2B0.54453131
91AKT30.54308330
92MAP3K60.53508544
93MAPK120.53377599
94CAMK2D0.50328514
95RPS6KA30.48467139
96ERBB30.48273351
97ERBB20.46266682
98PIK3CA0.45993684
99FYN0.45086064
100CSNK1A10.44965595
101DYRK20.44399120
102NUAK10.44163032
103FGFR20.44024445
104PDK10.43801995
105FGR0.43388404
106PDPK10.42670410
107STK38L0.42569852
108CSNK1D0.42127085
109PRKAA10.40824008
110PRKCA0.40707474
111ALK0.40151626
112CAMK2G0.40048658
113MAPKAPK50.39890102
114CAMK40.39544730
115PINK10.39529263
116CDC42BPA0.38790643
117MAPK100.38435589
118WNK10.37911309
119MAPK40.37305945
120NEK60.36684913
121LMTK20.36646330
122MAP3K10.36476837
123PRKG10.36241113
124TNK20.34459424
125GRK70.34420088
126PRKCB0.34303938
127SCYL20.33645830
128RPS6KA20.33645011
129LIMK10.33505628
130PRKACG0.33190233
131DAPK30.32000779

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.11179912
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20369332
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.87305209
4GABAergic synapse_Homo sapiens_hsa047272.84341998
5Circadian entrainment_Homo sapiens_hsa047132.71550529
6Long-term potentiation_Homo sapiens_hsa047202.68606204
7Glutamatergic synapse_Homo sapiens_hsa047242.67980050
8Morphine addiction_Homo sapiens_hsa050322.64918776
9Olfactory transduction_Homo sapiens_hsa047402.56753631
10Amphetamine addiction_Homo sapiens_hsa050312.41728666
11Dopaminergic synapse_Homo sapiens_hsa047282.18031566
12Salivary secretion_Homo sapiens_hsa049702.12670979
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.00327335
14Insulin secretion_Homo sapiens_hsa049111.99031551
15Cholinergic synapse_Homo sapiens_hsa047251.90364656
16Taste transduction_Homo sapiens_hsa047421.88079809
17Serotonergic synapse_Homo sapiens_hsa047261.83884360
18Renin secretion_Homo sapiens_hsa049241.80265905
19Long-term depression_Homo sapiens_hsa047301.80124851
20Gastric acid secretion_Homo sapiens_hsa049711.77942747
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74343544
22Cocaine addiction_Homo sapiens_hsa050301.69712781
23Oxytocin signaling pathway_Homo sapiens_hsa049211.66331318
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59353559
25Calcium signaling pathway_Homo sapiens_hsa040201.55038853
26Collecting duct acid secretion_Homo sapiens_hsa049661.53320142
27Phototransduction_Homo sapiens_hsa047441.38137123
28GnRH signaling pathway_Homo sapiens_hsa049121.38117954
29Gap junction_Homo sapiens_hsa045401.37354650
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32411009
31Axon guidance_Homo sapiens_hsa043601.31176640
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26566736
33cAMP signaling pathway_Homo sapiens_hsa040241.25726087
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23156804
35Type II diabetes mellitus_Homo sapiens_hsa049301.21483482
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20744566
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17533094
38Estrogen signaling pathway_Homo sapiens_hsa049151.17155543
39ErbB signaling pathway_Homo sapiens_hsa040121.06957931
40Glioma_Homo sapiens_hsa052141.05623316
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04479434
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04164791
43Melanogenesis_Homo sapiens_hsa049161.02325621
44Cardiac muscle contraction_Homo sapiens_hsa042601.01999417
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99805754
46Vibrio cholerae infection_Homo sapiens_hsa051100.98173111
47Butanoate metabolism_Homo sapiens_hsa006500.95423823
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90292153
49alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85592911
50Linoleic acid metabolism_Homo sapiens_hsa005910.83603311
51Oocyte meiosis_Homo sapiens_hsa041140.83136873
52Dorso-ventral axis formation_Homo sapiens_hsa043200.83072015
53Pancreatic secretion_Homo sapiens_hsa049720.80591398
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79997793
55Tryptophan metabolism_Homo sapiens_hsa003800.79837639
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.77770526
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77282656
58Dilated cardiomyopathy_Homo sapiens_hsa054140.75091538
59Ether lipid metabolism_Homo sapiens_hsa005650.73395154
60Thyroid hormone synthesis_Homo sapiens_hsa049180.72333131
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72175931
62MAPK signaling pathway_Homo sapiens_hsa040100.71858508
63Choline metabolism in cancer_Homo sapiens_hsa052310.67935050
64* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62993748
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60847546
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60487570
67Ras signaling pathway_Homo sapiens_hsa040140.60076665
68ABC transporters_Homo sapiens_hsa020100.59927738
69Melanoma_Homo sapiens_hsa052180.59546699
70Glycerolipid metabolism_Homo sapiens_hsa005610.58390316
71Circadian rhythm_Homo sapiens_hsa047100.58104271
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58072894
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57430583
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.55725444
75Alcoholism_Homo sapiens_hsa050340.55629389
76Glucagon signaling pathway_Homo sapiens_hsa049220.54773636
77Renal cell carcinoma_Homo sapiens_hsa052110.53187886
78Fatty acid biosynthesis_Homo sapiens_hsa000610.53034077
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52071529
80VEGF signaling pathway_Homo sapiens_hsa043700.52049529
81Alzheimers disease_Homo sapiens_hsa050100.51970381
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.50890653
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50875283
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50605560
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49740614
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49388546
87Regulation of autophagy_Homo sapiens_hsa041400.48770864
88Rap1 signaling pathway_Homo sapiens_hsa040150.47853454
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47511454
90Wnt signaling pathway_Homo sapiens_hsa043100.47078876
91mTOR signaling pathway_Homo sapiens_hsa041500.46516936
92Endometrial cancer_Homo sapiens_hsa052130.45914371
93beta-Alanine metabolism_Homo sapiens_hsa004100.44200669
94Prion diseases_Homo sapiens_hsa050200.42880647
95Inositol phosphate metabolism_Homo sapiens_hsa005620.42588343
96Hippo signaling pathway_Homo sapiens_hsa043900.42465601
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42422559
98Type I diabetes mellitus_Homo sapiens_hsa049400.42013021
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41935849
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40415067
101Nitrogen metabolism_Homo sapiens_hsa009100.39691936
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.39122624
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38871085
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.38608700
105Hedgehog signaling pathway_Homo sapiens_hsa043400.38583099
106Insulin signaling pathway_Homo sapiens_hsa049100.38576202
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37365669
108Bile secretion_Homo sapiens_hsa049760.35611211
109Ovarian steroidogenesis_Homo sapiens_hsa049130.35555997
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34762728
111Endocytosis_Homo sapiens_hsa041440.33654827
112Histidine metabolism_Homo sapiens_hsa003400.33438976
113Non-small cell lung cancer_Homo sapiens_hsa052230.32083647
114African trypanosomiasis_Homo sapiens_hsa051430.31857904
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31131750
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30677183
117Colorectal cancer_Homo sapiens_hsa052100.29633287
118Retinol metabolism_Homo sapiens_hsa008300.28449669
119Chemokine signaling pathway_Homo sapiens_hsa040620.27418244
120Oxidative phosphorylation_Homo sapiens_hsa001900.27085671
121Protein digestion and absorption_Homo sapiens_hsa049740.26968691
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.25391645
123SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25216034
124Chemical carcinogenesis_Homo sapiens_hsa052040.23521033

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