NEK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)4.67591645
2neuron cell-cell adhesion (GO:0007158)4.30265795
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.26887149
4cilium movement (GO:0003341)4.22295360
5proline transport (GO:0015824)4.07479518
6retinal cone cell development (GO:0046549)3.88840259
7protein localization to synapse (GO:0035418)3.86816966
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.77438074
9vocalization behavior (GO:0071625)3.69327472
10regulation of synaptic vesicle exocytosis (GO:2000300)3.68479708
11synaptic vesicle exocytosis (GO:0016079)3.63577681
12centriole replication (GO:0007099)3.62172873
13cerebellar Purkinje cell differentiation (GO:0021702)3.58121448
14synaptic vesicle docking involved in exocytosis (GO:0016081)3.57155688
15response to pheromone (GO:0019236)3.50365794
16epithelial cilium movement (GO:0003351)3.47973442
17innervation (GO:0060384)3.47742760
18neuronal action potential propagation (GO:0019227)3.45969728
19membrane depolarization during action potential (GO:0086010)3.40756925
20protein K11-linked deubiquitination (GO:0035871)3.39037964
21positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.32098941
22cell migration in hindbrain (GO:0021535)3.31073946
23synaptic vesicle maturation (GO:0016188)3.30817910
24glutamate secretion (GO:0014047)3.30544682
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.26802642
26negative regulation of dendrite morphogenesis (GO:0050774)3.26267495
27neurotransmitter secretion (GO:0007269)3.23316899
28behavioral response to ethanol (GO:0048149)3.23294463
29phenol-containing compound catabolic process (GO:0019336)3.22308357
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22250247
31regulation of synaptic vesicle transport (GO:1902803)3.21006516
32axonemal dynein complex assembly (GO:0070286)3.20241160
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14122659
34DNA methylation involved in gamete generation (GO:0043046)3.13748038
35locomotory exploration behavior (GO:0035641)3.12670868
36glutamate receptor signaling pathway (GO:0007215)3.11189052
37regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.08688408
38positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.07276624
39presynaptic membrane assembly (GO:0097105)3.06128713
40male meiosis (GO:0007140)3.05240615
41synaptic transmission, glutamatergic (GO:0035249)3.04213711
42gamma-aminobutyric acid transport (GO:0015812)3.04078888
43interkinetic nuclear migration (GO:0022027)3.04004941
44axoneme assembly (GO:0035082)3.02577129
45synapsis (GO:0007129)3.02553722
46regulation of glutamate receptor signaling pathway (GO:1900449)3.02263743
47membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.02017079
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.01959043
49DNA double-strand break processing (GO:0000729)3.01504571
50positive regulation of histone H3-K4 methylation (GO:0051571)3.01173200
51brain morphogenesis (GO:0048854)2.99915462
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99662734
53neuron-neuron synaptic transmission (GO:0007270)2.98318764
54regulation of synaptic transmission, glutamatergic (GO:0051966)2.97804320
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89731087
56activation of protein kinase A activity (GO:0034199)2.84764408
57neuron recognition (GO:0008038)2.84219164
58axonal fasciculation (GO:0007413)2.84213361
59presynaptic membrane organization (GO:0097090)2.83786941
60neurotransmitter-gated ion channel clustering (GO:0072578)2.83623176
61male meiosis I (GO:0007141)2.82396424
62calcium ion-dependent exocytosis (GO:0017156)2.82129004
63fear response (GO:0042596)2.82114755
64positive regulation of meiosis (GO:0045836)2.81465077
65acrosome reaction (GO:0007340)2.80925798
66synaptic vesicle endocytosis (GO:0048488)2.80482605
67intraciliary transport (GO:0042073)2.79972226
68transmission of nerve impulse (GO:0019226)2.79293019
69meiotic cell cycle (GO:0051321)2.79088509
70regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78343637
71ventricular system development (GO:0021591)2.77632913
72neuronal action potential (GO:0019228)2.76697295
73neurotransmitter transport (GO:0006836)2.76517036
74regulation of neurotransmitter secretion (GO:0046928)2.76465010
75* cellular component assembly involved in morphogenesis (GO:0010927)2.75933373
76nonmotile primary cilium assembly (GO:0035058)2.75639552
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75290607
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75290607
79positive regulation of mitotic sister chromatid separation (GO:1901970)2.75290607
80sperm motility (GO:0030317)2.74952438
81establishment of protein localization to Golgi (GO:0072600)2.73791446
82exploration behavior (GO:0035640)2.73680365
83regulation of vesicle fusion (GO:0031338)2.73405776
84cochlea development (GO:0090102)2.71724544
85protein localization to cilium (GO:0061512)2.71349149
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.70373367
87multicellular organism reproduction (GO:0032504)2.69770021
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.68998912
89regulation of neuronal synaptic plasticity (GO:0048168)2.68566757
90neuromuscular synaptic transmission (GO:0007274)2.68407038
91negative regulation of dendrite development (GO:2000171)2.68293925
92detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67512709
93piRNA metabolic process (GO:0034587)2.66886670
94regulation of centriole replication (GO:0046599)2.66172376
95striatum development (GO:0021756)2.65798262
96neural tube formation (GO:0001841)2.65159311
97regulation of neurotransmitter transport (GO:0051588)2.64575937
98centriole assembly (GO:0098534)2.63692254
99acrosome assembly (GO:0001675)2.63379078
100synapse assembly (GO:0007416)2.62912284
101postreplication repair (GO:0006301)2.61706465
102vesicle transport along microtubule (GO:0047496)2.59398310
103microtubule-based movement (GO:0007018)2.59207180
104left/right axis specification (GO:0070986)2.58633291
105photoreceptor cell maintenance (GO:0045494)2.57961189
106positive regulation of meiotic cell cycle (GO:0051446)2.57940688
107replication fork processing (GO:0031297)2.56986688
108sympathetic nervous system development (GO:0048485)2.56834158
109behavioral fear response (GO:0001662)2.56559807
110behavioral defense response (GO:0002209)2.56559807
111long-term memory (GO:0007616)2.55585387
112urinary tract smooth muscle contraction (GO:0014848)2.55581210
113regulation of respiratory gaseous exchange (GO:0043576)2.55560841
114serotonin receptor signaling pathway (GO:0007210)2.55120193
115synaptonemal complex organization (GO:0070193)2.53692698
116neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.53088583
117regulation of DNA endoreduplication (GO:0032875)2.52780710
118microtubule anchoring (GO:0034453)2.51011097
119protein targeting to Golgi (GO:0000042)2.50299469
120cilium morphogenesis (GO:0060271)2.49789364
121regulation of respiratory system process (GO:0044065)2.49617063
122* cilium organization (GO:0044782)2.48946997
123neurotransmitter catabolic process (GO:0042135)2.48913095
124negative regulation of hormone metabolic process (GO:0032351)2.47905856
125negative regulation of hormone biosynthetic process (GO:0032353)2.47905856
126neuron fate determination (GO:0048664)2.47135022
127regulation of postsynaptic membrane potential (GO:0060078)2.47048903
128membrane depolarization (GO:0051899)2.46910296
129inositol phosphate catabolic process (GO:0071545)2.44841950
130hippocampus development (GO:0021766)2.44595232
131regulation of neurotransmitter levels (GO:0001505)2.44549341
132retinal ganglion cell axon guidance (GO:0031290)2.43922430
133layer formation in cerebral cortex (GO:0021819)2.43534287
134* cilium assembly (GO:0042384)2.43239388
135regulation of meiosis I (GO:0060631)2.42458688
136regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42322181
137photoreceptor cell development (GO:0042461)2.42013645
138protein polyglutamylation (GO:0018095)2.41973412
139positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.41856379
140cell differentiation in hindbrain (GO:0021533)2.41489483
141reciprocal meiotic recombination (GO:0007131)2.40627383
142reciprocal DNA recombination (GO:0035825)2.40627383
143synaptic transmission (GO:0007268)2.40248477
144pyrimidine nucleobase catabolic process (GO:0006208)2.39452080
145protein K6-linked ubiquitination (GO:0085020)2.39430380
146mitotic sister chromatid cohesion (GO:0007064)2.38540495
147regulation of acrosome reaction (GO:0060046)2.37810112
148regulation of cilium movement (GO:0003352)2.37588981
149cyclic nucleotide catabolic process (GO:0009214)2.36492944
150cAMP catabolic process (GO:0006198)2.36334493
151smoothened signaling pathway (GO:0007224)2.34747334
152nucleus localization (GO:0051647)2.34343390
153inner ear receptor stereocilium organization (GO:0060122)2.32869821
154retrograde transport, vesicle recycling within Golgi (GO:0000301)2.32261851
155chromosome organization involved in meiosis (GO:0070192)2.30448409
156relaxation of smooth muscle (GO:0044557)2.29188680
157detection of light stimulus involved in visual perception (GO:0050908)2.28290601
158detection of light stimulus involved in sensory perception (GO:0050962)2.28290601
159dopamine transport (GO:0015872)2.27775809
160attachment of spindle microtubules to kinetochore (GO:0008608)2.27672536
161protein-cofactor linkage (GO:0018065)2.27516069
162gene silencing by RNA (GO:0031047)2.27311141
163eye photoreceptor cell development (GO:0042462)2.27305509
164microtubule bundle formation (GO:0001578)2.27101669
165double-strand break repair via homologous recombination (GO:0000724)2.25867761
166microtubule depolymerization (GO:0007019)2.25471510
167recombinational repair (GO:0000725)2.25280733
168mechanosensory behavior (GO:0007638)2.24954888
169negative regulation of cytosolic calcium ion concentration (GO:0051481)2.23457108
170central nervous system neuron axonogenesis (GO:0021955)2.22578502
171translesion synthesis (GO:0019985)2.22437851
172behavioral response to nicotine (GO:0035095)2.21890548
173polyol catabolic process (GO:0046174)2.21005199
174regulation of DNA methylation (GO:0044030)2.20303096
175sister chromatid cohesion (GO:0007062)2.18277980
176single strand break repair (GO:0000012)2.17587608
177auditory behavior (GO:0031223)2.17132987
178microtubule polymerization or depolymerization (GO:0031109)2.16984590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.96686608
2GBX2_23144817_ChIP-Seq_PC3_Human3.60680110
3TAF15_26573619_Chip-Seq_HEK293_Human2.57472419
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.43041800
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.41519587
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41013209
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34769481
8SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.29426947
9FUS_26573619_Chip-Seq_HEK293_Human2.21316975
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21300415
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20263879
12SMAD4_21799915_ChIP-Seq_A2780_Human2.10599541
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08293855
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08209899
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02926215
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02718568
17JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02322429
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99286222
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97853316
20SMAD_19615063_ChIP-ChIP_OVARY_Human1.97076347
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96752438
22P300_19829295_ChIP-Seq_ESCs_Human1.96605034
23AR_21572438_ChIP-Seq_LNCaP_Human1.90462953
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.88743709
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86909617
26REST_21632747_ChIP-Seq_MESCs_Mouse1.86349088
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86323849
28RNF2_27304074_Chip-Seq_NSC_Mouse1.84866734
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.75597633
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75330650
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.72935671
32IGF1R_20145208_ChIP-Seq_DFB_Human1.72757670
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71942944
34EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71942944
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69401283
36* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67975155
37* STAT3_23295773_ChIP-Seq_U87_Human1.65705816
38CBP_20019798_ChIP-Seq_JUKART_Human1.62557922
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.62557922
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60169738
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60048438
42EWS_26573619_Chip-Seq_HEK293_Human1.59476127
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58586237
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.56899516
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.56709736
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56548807
47* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55544141
48POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.54843288
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54843288
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.54217234
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.53889450
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.52300756
53SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51152907
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50967991
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50629975
56* TCF4_23295773_ChIP-Seq_U87_Human1.50327106
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.50312391
58RNF2_27304074_Chip-Seq_ESCs_Mouse1.49404121
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49284748
60AR_25329375_ChIP-Seq_VCAP_Human1.48746052
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48218505
62SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46619304
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45070989
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42875154
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42549441
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41928986
67EED_16625203_ChIP-ChIP_MESCs_Mouse1.39416736
68SOX2_21211035_ChIP-Seq_LN229_Gbm1.38727736
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.37012098
70EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36644936
71BCAT_22108803_ChIP-Seq_LS180_Human1.36273519
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35434333
73ZNF274_21170338_ChIP-Seq_K562_Hela1.34897063
74VDR_22108803_ChIP-Seq_LS180_Human1.34328523
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.33865963
76DROSHA_22980978_ChIP-Seq_HELA_Human1.30537053
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30491410
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29240456
79TP53_16413492_ChIP-PET_HCT116_Human1.29084805
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28849906
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28273094
82ER_23166858_ChIP-Seq_MCF-7_Human1.28035597
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.27898440
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27319760
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26824940
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.25749600
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.25689503
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25445000
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.25299867
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.24821061
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22916379
92* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22876300
93P53_22387025_ChIP-Seq_ESCs_Mouse1.22856257
94JUN_21703547_ChIP-Seq_K562_Human1.22598613
95TCF4_22108803_ChIP-Seq_LS180_Human1.22046537
96* TAL1_26923725_Chip-Seq_HPCs_Mouse1.21789444
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.21497175
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21231174
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.21140944
100* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19702928
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19219961
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.18976163
103CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18214687
104FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17843409
105AR_19668381_ChIP-Seq_PC3_Human1.16937654
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.16154747
107SOX2_19829295_ChIP-Seq_ESCs_Human1.14715824
108NANOG_19829295_ChIP-Seq_ESCs_Human1.14715824
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.14643558
110RARB_27405468_Chip-Seq_BRAIN_Mouse1.14304900
111AHR_22903824_ChIP-Seq_MCF-7_Human1.14093386
112HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13835614
113HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13497156
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13473193
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13280549
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.13233636
117KDM2B_26808549_Chip-Seq_REH_Human1.13098512
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.12128637
119TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11576590
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11403541
121SOX9_26525672_Chip-Seq_HEART_Mouse1.11340872
122* SMAD4_21741376_ChIP-Seq_EPCs_Human1.09503062
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.05846277
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05804371
125PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04612135
126* CDX2_22108803_ChIP-Seq_LS180_Human1.03689938
127ELK1_19687146_ChIP-ChIP_HELA_Human1.02317166
128TP53_22573176_ChIP-Seq_HFKS_Human1.01776877
129STAT3_18555785_Chip-Seq_ESCs_Mouse0.99679964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.63369924
2MP0003787_abnormal_imprinting3.47827541
3MP0001968_abnormal_touch/_nociception3.23582453
4MP0004270_analgesia2.92116553
5MP0002735_abnormal_chemical_nociception2.91485881
6MP0003880_abnormal_central_pattern2.88441730
7MP0008877_abnormal_DNA_methylation2.85433989
8MP0003635_abnormal_synaptic_transmissio2.81699714
9MP0002822_catalepsy2.79861275
10MP0002734_abnormal_mechanical_nocicepti2.70733614
11MP0002736_abnormal_nociception_after2.66968296
12MP0009046_muscle_twitch2.50776073
13MP0009745_abnormal_behavioral_response2.43790909
14MP0006276_abnormal_autonomic_nervous2.38914669
15MP0002063_abnormal_learning/memory/cond2.24595944
16MP0003718_maternal_effect2.21013685
17MP0008057_abnormal_DNA_replication2.18998180
18MP0002572_abnormal_emotion/affect_behav2.18569769
19MP0002272_abnormal_nervous_system2.12714398
20MP0003123_paternal_imprinting2.03211529
21MP0000569_abnormal_digit_pigmentation2.02084584
22MP0002064_seizures1.99833999
23MP0002733_abnormal_thermal_nociception1.99789208
24MP0005646_abnormal_pituitary_gland1.99479672
25MP0003121_genomic_imprinting1.94335751
26MP0001486_abnormal_startle_reflex1.90417652
27MP0002067_abnormal_sensory_capabilities1.89800452
28MP0000778_abnormal_nervous_system1.88139887
29MP0008058_abnormal_DNA_repair1.87627749
30MP0003136_yellow_coat_color1.82808329
31MP0001970_abnormal_pain_threshold1.82531653
32MP0002184_abnormal_innervation1.82452062
33MP0001984_abnormal_olfaction1.77598655
34MP0005423_abnormal_somatic_nervous1.77081492
35MP0004858_abnormal_nervous_system1.76728310
36MP0002653_abnormal_ependyma_morphology1.71927352
37MP0001501_abnormal_sleep_pattern1.71341138
38MP0003879_abnormal_hair_cell1.67397982
39MP0001440_abnormal_grooming_behavior1.67252498
40MP0002938_white_spotting1.64059994
41MP0003122_maternal_imprinting1.51246333
42MP0002557_abnormal_social/conspecific_i1.49097097
43MP0004133_heterotaxia1.45417615
44MP0002638_abnormal_pupillary_reflex1.43066372
45MP0003890_abnormal_embryonic-extraembry1.42474155
46MP0000955_abnormal_spinal_cord1.41389600
47MP0008569_lethality_at_weaning1.40961907
48MP0002234_abnormal_pharynx_morphology1.40079138
49MP0000372_irregular_coat_pigmentation1.39092793
50MP0001529_abnormal_vocalization1.38822492
51MP0005386_behavior/neurological_phenoty1.38115177
52MP0004924_abnormal_behavior1.38115177
53MP0001986_abnormal_taste_sensitivity1.37592531
54MP0005174_abnormal_tail_pigmentation1.36982399
55MP0004885_abnormal_endolymph1.36495137
56MP0002928_abnormal_bile_duct1.35987523
57MP0000427_abnormal_hair_cycle1.35209309
58MP0010386_abnormal_urinary_bladder1.34922813
59MP0003195_calcinosis1.34818799
60MP0009697_abnormal_copulation1.29760734
61MP0001188_hyperpigmentation1.29642059
62MP0002882_abnormal_neuron_morphology1.25240729
63MP0001905_abnormal_dopamine_level1.24844107
64MP0005623_abnormal_meninges_morphology1.24003979
65MP0004811_abnormal_neuron_physiology1.23609052
66MP0009780_abnormal_chondrocyte_physiolo1.23510639
67MP0004215_abnormal_myocardial_fiber1.21057975
68MP0001485_abnormal_pinna_reflex1.19950205
69MP0001963_abnormal_hearing_physiology1.18410502
70MP0010094_abnormal_chromosome_stability1.18269965
71MP0006072_abnormal_retinal_apoptosis1.17393337
72MP0003329_amyloid_beta_deposits1.15621784
73MP0004043_abnormal_pH_regulation1.15521322
74MP0002751_abnormal_autonomic_nervous1.14818850
75* MP0003698_abnormal_male_reproductive1.13695892
76MP0005551_abnormal_eye_electrophysiolog1.11778879
77MP0005367_renal/urinary_system_phenotyp1.09449649
78MP0000516_abnormal_urinary_system1.09449649
79MP0006292_abnormal_olfactory_placode1.08162183
80MP0005410_abnormal_fertilization1.07451920
81MP0002160_abnormal_reproductive_system1.06678386
82* MP0002152_abnormal_brain_morphology1.05584922
83MP0005075_abnormal_melanosome_morpholog1.05133147
84MP0002876_abnormal_thyroid_physiology1.02952407
85MP0000631_abnormal_neuroendocrine_gland0.97844190
86MP0002066_abnormal_motor_capabilities/c0.97431142
87MP0000015_abnormal_ear_pigmentation0.97341329
88MP0002095_abnormal_skin_pigmentation0.97064853
89MP0005645_abnormal_hypothalamus_physiol0.96734188
90MP0002752_abnormal_somatic_nervous0.96260357
91MP0005499_abnormal_olfactory_system0.94617131
92MP0005394_taste/olfaction_phenotype0.94617131
93MP0003633_abnormal_nervous_system0.94450451
94MP0003631_nervous_system_phenotype0.93533518
95MP0003632_abnormal_nervous_system0.93174543
96* MP0001929_abnormal_gametogenesis0.92151893
97* MP0003861_abnormal_nervous_system0.92149412
98MP0005395_other_phenotype0.91924248
99MP0005195_abnormal_posterior_eye0.91673107
100* MP0001145_abnormal_male_reproductive0.91535004
101MP0005391_vision/eye_phenotype0.90954671
102MP0000383_abnormal_hair_follicle0.90903823
103MP0000013_abnormal_adipose_tissue0.90177767
104MP0003011_delayed_dark_adaptation0.89717127
105MP0004147_increased_porphyrin_level0.88556828
106MP0005389_reproductive_system_phenotype0.88275754
107MP0002909_abnormal_adrenal_gland0.86996334
108MP0001324_abnormal_eye_pigmentation0.85285153
109MP0002233_abnormal_nose_morphology0.84373637
110MP0002102_abnormal_ear_morphology0.83866268
111MP0008872_abnormal_physiological_respon0.83206693
112MP0009250_abnormal_appendicular_skeleto0.82986603
113MP0002163_abnormal_gland_morphology0.82920640
114MP0001293_anophthalmia0.82233568
115MP0003937_abnormal_limbs/digits/tail_de0.82066085
116* MP0002210_abnormal_sex_determination0.81739439
117MP0000026_abnormal_inner_ear0.81566948
118MP0005220_abnormal_exocrine_pancreas0.81309549
119MP0005248_abnormal_Harderian_gland0.81114767
120MP0002229_neurodegeneration0.78949122
121MP0004742_abnormal_vestibular_system0.78380886
122MP0003942_abnormal_urinary_system0.77056745
123MP0001299_abnormal_eye_distance/0.76633830
124MP0001177_atelectasis0.76586690
125MP0000534_abnormal_ureter_morphology0.76280907
126MP0002837_dystrophic_cardiac_calcinosis0.75814556
127MP0008789_abnormal_olfactory_epithelium0.75438915
128MP0004142_abnormal_muscle_tone0.73903509
129MP0005171_absent_coat_pigmentation0.71570849
130MP0005253_abnormal_eye_physiology0.71192119
131MP0003755_abnormal_palate_morphology0.70964311
132MP0004145_abnormal_muscle_electrophysio0.70753149
133MP0001943_abnormal_respiration0.69746775
134MP0001270_distended_abdomen0.69387717
135MP0004085_abnormal_heartbeat0.69320756
136* MP0000653_abnormal_sex_gland0.67027377
137MP0002009_preneoplasia0.66417098

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.17839122
2Abnormal respiratory motile cilium physiology (HP:0012261)4.53589233
3Abnormal ciliary motility (HP:0012262)4.32754229
4Hypothermia (HP:0002045)4.13979350
5Focal motor seizures (HP:0011153)3.93753920
6* Metaphyseal dysplasia (HP:0100255)3.92976542
7Febrile seizures (HP:0002373)3.80998822
8Rhinitis (HP:0012384)3.58372389
9Myokymia (HP:0002411)3.44014983
10Focal seizures (HP:0007359)3.43673086
11Progressive cerebellar ataxia (HP:0002073)3.38205634
12Atonic seizures (HP:0010819)3.30803864
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.25856732
14Absent/shortened dynein arms (HP:0200106)3.25856732
15Action tremor (HP:0002345)3.17672198
16Medial flaring of the eyebrow (HP:0010747)3.09016652
17Ulnar claw (HP:0001178)3.07534962
18Absent frontal sinuses (HP:0002688)3.01749424
19Abnormal respiratory epithelium morphology (HP:0012253)2.93461941
20Abnormal respiratory motile cilium morphology (HP:0005938)2.93461941
21Termporal pattern (HP:0011008)2.93413305
22Insidious onset (HP:0003587)2.93413305
23Epileptic encephalopathy (HP:0200134)2.92465913
24Abnormality of the renal cortex (HP:0011035)2.87658117
25Gait imbalance (HP:0002141)2.81999422
26* Pancreatic fibrosis (HP:0100732)2.70121499
27Type II lissencephaly (HP:0007260)2.63068311
28Congenital primary aphakia (HP:0007707)2.62381484
29Gaze-evoked nystagmus (HP:0000640)2.59497580
30Oligodactyly (hands) (HP:0001180)2.57092384
31Nephronophthisis (HP:0000090)2.56743996
32Hemiparesis (HP:0001269)2.52035627
33Molar tooth sign on MRI (HP:0002419)2.50995398
34Abnormality of midbrain morphology (HP:0002418)2.50995398
35Papillary thyroid carcinoma (HP:0002895)2.47079561
36Occipital encephalocele (HP:0002085)2.42921332
37Renal cortical cysts (HP:0000803)2.41902719
38Nephrogenic diabetes insipidus (HP:0009806)2.36894719
39Vaginal atresia (HP:0000148)2.35943830
40* Genital tract atresia (HP:0001827)2.35943830
41Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.32424191
42Absence seizures (HP:0002121)2.32122707
43* Aplasia/Hypoplasia of the tibia (HP:0005772)2.30270163
44Thyroid carcinoma (HP:0002890)2.29378975
45Generalized tonic-clonic seizures (HP:0002069)2.28452820
46True hermaphroditism (HP:0010459)2.22007062
47Tubular atrophy (HP:0000092)2.21182088
48Retinal dysplasia (HP:0007973)2.15321312
49Congenital hepatic fibrosis (HP:0002612)2.15278674
50Drooling (HP:0002307)2.12220778
51Excessive salivation (HP:0003781)2.12220778
52Amyotrophic lateral sclerosis (HP:0007354)2.11922803
53Impaired vibration sensation in the lower limbs (HP:0002166)2.11219002
54Narrow forehead (HP:0000341)2.11062393
55Chronic hepatic failure (HP:0100626)2.08821630
56Poor coordination (HP:0002370)2.08288106
57Fair hair (HP:0002286)2.07058819
58Anencephaly (HP:0002323)2.03744246
59Abnormality of the labia minora (HP:0012880)2.02874362
60Dialeptic seizures (HP:0011146)2.02791702
61Oculomotor apraxia (HP:0000657)2.01648965
62Epiphyseal dysplasia (HP:0002656)2.01520925
63Tubulointerstitial nephritis (HP:0001970)2.00424315
64Urinary bladder sphincter dysfunction (HP:0002839)1.98438491
65Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.98362722
66Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.98127831
67Mild short stature (HP:0003502)1.97973509
68Abnormality of abdominal situs (HP:0011620)1.97555685
69Abdominal situs inversus (HP:0003363)1.97555685
70Amblyopia (HP:0000646)1.97342974
71Specific learning disability (HP:0001328)1.97310475
72Truncal ataxia (HP:0002078)1.96871400
73Biliary tract neoplasm (HP:0100574)1.95524759
74Prominent nasal bridge (HP:0000426)1.95179995
75Fetal akinesia sequence (HP:0001989)1.94960267
76Attenuation of retinal blood vessels (HP:0007843)1.93740154
77Abnormality of the renal medulla (HP:0100957)1.92418154
78Intestinal atresia (HP:0011100)1.92219508
79Abnormality of chromosome stability (HP:0003220)1.91792447
80Broad-based gait (HP:0002136)1.91281721
81Bifid tongue (HP:0010297)1.91252631
82Sclerocornea (HP:0000647)1.90923328
83Abnormality of the lower motor neuron (HP:0002366)1.90549958
84Supernumerary spleens (HP:0009799)1.88333376
85Oligodactyly (HP:0012165)1.87776261
86Cerebellar dysplasia (HP:0007033)1.87761632
87Fibular hypoplasia (HP:0003038)1.87383887
88* Short tibia (HP:0005736)1.86087330
89Volvulus (HP:0002580)1.86004055
90Neonatal hypoglycemia (HP:0001998)1.84700361
91Progressive inability to walk (HP:0002505)1.84547140
92Chorioretinal atrophy (HP:0000533)1.83848759
93Abolished electroretinogram (ERG) (HP:0000550)1.83559242
94Highly arched eyebrow (HP:0002553)1.82460057
95Impaired smooth pursuit (HP:0007772)1.82279249
96* Median cleft lip (HP:0000161)1.81935905
97Small hand (HP:0200055)1.81837387
98Congenital stationary night blindness (HP:0007642)1.81530478
99Embryonal renal neoplasm (HP:0011794)1.80912339
100Methylmalonic acidemia (HP:0002912)1.80737372
101Bile duct proliferation (HP:0001408)1.80693785
102Abnormal biliary tract physiology (HP:0012439)1.80693785
103Hyperventilation (HP:0002883)1.80284726
104Abnormal biliary tract morphology (HP:0012440)1.80137565
105Tubulointerstitial abnormality (HP:0001969)1.79958062
106Renal dysplasia (HP:0000110)1.79287839
107Abnormality of the corticospinal tract (HP:0002492)1.78794524
108Furrowed tongue (HP:0000221)1.77557149
109Aganglionic megacolon (HP:0002251)1.77214653
110Abnormal hair whorl (HP:0010721)1.76724802
111Facial hemangioma (HP:0000329)1.76556266
112Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.76004895
113* Postaxial hand polydactyly (HP:0001162)1.75912994
114Lissencephaly (HP:0001339)1.74754019
115Male pseudohermaphroditism (HP:0000037)1.74296020
116Steppage gait (HP:0003376)1.73914670
117Abnormality of ocular smooth pursuit (HP:0000617)1.73507979
118Optic nerve hypoplasia (HP:0000609)1.73500542
119Aplasia/Hypoplasia of the lens (HP:0008063)1.73110061
120Visual hallucinations (HP:0002367)1.72544258
121Polyphagia (HP:0002591)1.72375426
122Postural tremor (HP:0002174)1.71924890
123Pancreatic cysts (HP:0001737)1.71590539
124* Preaxial hand polydactyly (HP:0001177)1.70559434
125Polydipsia (HP:0001959)1.69999083
126Abnormal drinking behavior (HP:0030082)1.69999083
127* Postaxial foot polydactyly (HP:0001830)1.69158675
128Ankle clonus (HP:0011448)1.68440843
129Cystic liver disease (HP:0006706)1.68349368
130Limb dystonia (HP:0002451)1.68224543
131Irregular epiphyses (HP:0010582)1.65985202
132Dysdiadochokinesis (HP:0002075)1.65618369
133Bradycardia (HP:0001662)1.65424862
134Abnormality of the pubic bones (HP:0003172)1.65101531
135Nephroblastoma (Wilms tumor) (HP:0002667)1.64461921
136* Pachygyria (HP:0001302)1.64048561
137* Short ribs (HP:0000773)1.63524242
138Dandy-Walker malformation (HP:0001305)1.62786311
139Anterior segment dysgenesis (HP:0007700)1.62368746
140Sloping forehead (HP:0000340)1.61063732
141Autoamputation (HP:0001218)1.60826882
142Prostate neoplasm (HP:0100787)1.60531009
143Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.60318661
144Bronchiectasis (HP:0002110)1.60105504
145Facial cleft (HP:0002006)1.59982041
146Bell-shaped thorax (HP:0001591)1.59851497
147Short foot (HP:0001773)1.59610026
148* Aplasia/Hypoplasia of the tongue (HP:0010295)1.58456189
149Astigmatism (HP:0000483)1.58351933
150Chronic bronchitis (HP:0004469)1.57489829
151Absent speech (HP:0001344)1.57263093
152Protruding tongue (HP:0010808)1.56896615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.68665419
2NTRK33.99948990
3MAP3K43.83219547
4MAP2K73.47811595
5MAP3K93.06819135
6MAP4K22.93184791
7CASK2.85673985
8BMPR1B2.67041588
9WNK32.48884959
10EPHA42.41323226
11PNCK2.31797451
12NTRK12.15923969
13NUAK12.09017173
14MINK12.03288816
15PINK11.94783602
16PLK21.92873392
17MAP2K41.83679066
18MAPK131.83525106
19ACVR1B1.78943303
20MARK11.78468959
21LATS21.72988222
22STK391.65874817
23SGK21.63380815
24MAP3K121.54570221
25TAOK31.52775563
26MST41.51139968
27NTRK21.48604186
28TAF11.47665322
29DAPK21.47454482
30BCR1.46432496
31EIF2AK31.46244899
32TRIM281.37601975
33KSR21.32700190
34GRK51.29615500
35SIK21.27399300
36PRKD31.21786147
37LMTK21.21490191
38SGK4941.20458436
39SGK2231.20458436
40PRPF4B1.17245387
41STK31.17120294
42STK241.16699755
43BRSK21.16611047
44MAP3K21.16298815
45ADRBK21.14860905
46AKT31.10104862
47BMPR21.09606199
48ARAF1.07593433
49GRK11.07535387
50VRK11.06354772
51CDC71.06066043
52PAK61.05288667
53PRKCG1.03671964
54RPS6KA21.02156816
55KSR11.01300393
56FGFR21.00084048
57OXSR10.99216234
58DYRK1A0.98409797
59PLK30.97840634
60WNK40.96603606
61CDK50.95180815
62ERBB30.94616647
63SGK30.93594518
64DDR20.92956939
65STK38L0.92767625
66PDK40.92031020
67PDK30.92031020
68WEE10.87878328
69SIK30.86292031
70WNK10.85976698
71TNIK0.85312682
72RET0.84511457
73PTK2B0.83703564
74MAPK150.83491163
75DAPK10.81471303
76CSNK1G10.80554889
77MAP3K60.80383072
78CAMK2A0.79411929
79STK380.79118947
80MKNK20.77310402
81CSNK1G20.75023418
82PRKCE0.74309050
83MARK20.74080037
84TTK0.72972366
85CCNB10.72882341
86RPS6KB10.72868451
87PLK10.71963935
88MAPK100.71842370
89DYRK30.70834870
90CDK30.70720911
91STK160.69900846
92CDK180.69112671
93PLK40.68505918
94LATS10.67695189
95RIPK40.67415551
96TGFBR10.64751786
97CDK150.64227833
98CSNK1G30.63831188
99RAF10.63642784
100MAPKAPK50.62268062
101SGK10.61810664
102CDK140.61280567
103ZAK0.60629731
104BRD40.60194185
105CDK90.59206267
106INSRR0.58697950
107BRAF0.57617358
108CDK80.57454384
109ERBB40.56747714
110PKN10.56456584
111NEK60.56235559
112ADRBK10.52745453
113SRPK10.52367730
114CSNK1E0.51442678
115MAP2K10.51440587
116EIF2AK10.51226352
117CHEK20.51115510
118CDK11A0.50055350
119PAK30.49725624
120FER0.49425391
121GSK3B0.49302665
122PIK3CA0.48991500
123RPS6KA40.48798213
124MAPK80.48796432
125CAMKK10.47593942
126STK110.47462590
127PDK10.47303200
128OBSCN0.45599382
129MKNK10.45506970
130TSSK60.45164597
131ATM0.44939912
132PHKG20.44821118
133PHKG10.44821118
134CSNK1A1L0.44357471
135RPS6KA30.42618670
136DYRK20.42321890
137ATR0.42129911
138MAPK140.41968357
139YES10.41899063
140PRKACB0.40529019
141CDK10.40023757
142CSNK1D0.39304053
143PRKACA0.38262190
144CDK120.37472110
145CAMK1G0.36952268
146PRKG10.36694375
147ROCK10.36208277
148MET0.35000142
149TEC0.33900465
150CAMK2D0.33396392

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41737441
2Protein export_Homo sapiens_hsa030602.71868504
3Synaptic vesicle cycle_Homo sapiens_hsa047212.67006298
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55960737
5Amphetamine addiction_Homo sapiens_hsa050312.54105029
6Circadian entrainment_Homo sapiens_hsa047132.49834251
7Long-term potentiation_Homo sapiens_hsa047202.42270892
8Taste transduction_Homo sapiens_hsa047422.37679581
9Glutamatergic synapse_Homo sapiens_hsa047242.35757661
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.30160391
11Olfactory transduction_Homo sapiens_hsa047402.24660605
12Butanoate metabolism_Homo sapiens_hsa006502.21677840
13Dopaminergic synapse_Homo sapiens_hsa047282.20756415
14GABAergic synapse_Homo sapiens_hsa047272.18556504
15Morphine addiction_Homo sapiens_hsa050322.18382556
16Insulin secretion_Homo sapiens_hsa049112.08819175
17Homologous recombination_Homo sapiens_hsa034402.07845771
18Cholinergic synapse_Homo sapiens_hsa047251.98226152
19Serotonergic synapse_Homo sapiens_hsa047261.96080180
20Non-homologous end-joining_Homo sapiens_hsa034501.95094180
21Salivary secretion_Homo sapiens_hsa049701.88379008
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80012189
23Propanoate metabolism_Homo sapiens_hsa006401.77461819
24Oocyte meiosis_Homo sapiens_hsa041141.72915741
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71564079
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.71130278
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68684258
28Dorso-ventral axis formation_Homo sapiens_hsa043201.67986000
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67566350
30Mismatch repair_Homo sapiens_hsa034301.67439536
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61651842
32Long-term depression_Homo sapiens_hsa047301.61356266
33Cocaine addiction_Homo sapiens_hsa050301.60717456
34Renin secretion_Homo sapiens_hsa049241.59989764
35GnRH signaling pathway_Homo sapiens_hsa049121.57151198
36Calcium signaling pathway_Homo sapiens_hsa040201.54809984
37Gastric acid secretion_Homo sapiens_hsa049711.49742576
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.44738743
39Selenocompound metabolism_Homo sapiens_hsa004501.43979895
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.40801889
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40627671
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.40083600
43Oxytocin signaling pathway_Homo sapiens_hsa049211.39995908
44Estrogen signaling pathway_Homo sapiens_hsa049151.37236774
45Caffeine metabolism_Homo sapiens_hsa002321.31939498
46Gap junction_Homo sapiens_hsa045401.29022550
47Steroid biosynthesis_Homo sapiens_hsa001001.27921035
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26727736
49Nucleotide excision repair_Homo sapiens_hsa034201.25895610
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24351877
51cAMP signaling pathway_Homo sapiens_hsa040241.23958648
52Linoleic acid metabolism_Homo sapiens_hsa005911.22693655
53Phototransduction_Homo sapiens_hsa047441.21141244
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19554081
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19407804
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18882408
57Thyroid hormone synthesis_Homo sapiens_hsa049181.18527190
58Nitrogen metabolism_Homo sapiens_hsa009101.18019741
59Melanogenesis_Homo sapiens_hsa049161.13977482
60Ovarian steroidogenesis_Homo sapiens_hsa049131.13699241
61Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11196712
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.09220561
63Folate biosynthesis_Homo sapiens_hsa007901.07687813
64Circadian rhythm_Homo sapiens_hsa047101.07172086
65Tryptophan metabolism_Homo sapiens_hsa003801.06273476
66RNA polymerase_Homo sapiens_hsa030201.05671940
67ErbB signaling pathway_Homo sapiens_hsa040121.04434061
68Type II diabetes mellitus_Homo sapiens_hsa049301.04394334
69Axon guidance_Homo sapiens_hsa043600.99753172
70ABC transporters_Homo sapiens_hsa020100.97755164
71Ether lipid metabolism_Homo sapiens_hsa005650.97032006
72Wnt signaling pathway_Homo sapiens_hsa043100.94661492
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94088599
74Regulation of autophagy_Homo sapiens_hsa041400.93948281
75Fatty acid elongation_Homo sapiens_hsa000620.92751635
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92123886
77Collecting duct acid secretion_Homo sapiens_hsa049660.91702283
78beta-Alanine metabolism_Homo sapiens_hsa004100.91049369
79Glucagon signaling pathway_Homo sapiens_hsa049220.89450037
80RNA degradation_Homo sapiens_hsa030180.89111747
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88669461
82Choline metabolism in cancer_Homo sapiens_hsa052310.86999357
83RNA transport_Homo sapiens_hsa030130.86711010
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86621509
85Pancreatic secretion_Homo sapiens_hsa049720.85200007
86Dilated cardiomyopathy_Homo sapiens_hsa054140.84829138
87Glioma_Homo sapiens_hsa052140.84396442
88Purine metabolism_Homo sapiens_hsa002300.84196069
89Peroxisome_Homo sapiens_hsa041460.83158537
90mRNA surveillance pathway_Homo sapiens_hsa030150.77479353
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76996082
92Oxidative phosphorylation_Homo sapiens_hsa001900.75185346
93One carbon pool by folate_Homo sapiens_hsa006700.75142076
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74894567
95Lysine degradation_Homo sapiens_hsa003100.74415421
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74154247
97Alcoholism_Homo sapiens_hsa050340.74106347
98MAPK signaling pathway_Homo sapiens_hsa040100.72706899
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72662170
100Parkinsons disease_Homo sapiens_hsa050120.71959848
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71860627
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71467079
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.69627041
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.69159698
105Cysteine and methionine metabolism_Homo sapiens_hsa002700.67851300
106Hedgehog signaling pathway_Homo sapiens_hsa043400.64611332
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64369653
108Basal transcription factors_Homo sapiens_hsa030220.64090429
109Endometrial cancer_Homo sapiens_hsa052130.63813749
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63421214
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60423775
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.60134045
113Cardiac muscle contraction_Homo sapiens_hsa042600.59274929
114Retinol metabolism_Homo sapiens_hsa008300.58434299
115Colorectal cancer_Homo sapiens_hsa052100.58385778
116Chemical carcinogenesis_Homo sapiens_hsa052040.57961585
117Ras signaling pathway_Homo sapiens_hsa040140.55741980
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52882193
119p53 signaling pathway_Homo sapiens_hsa041150.52776903
120Inositol phosphate metabolism_Homo sapiens_hsa005620.52097501
121Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51894475
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.51185391
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49520414
124Huntingtons disease_Homo sapiens_hsa050160.49101201
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49100686
126Insulin signaling pathway_Homo sapiens_hsa049100.48992340
127Cell cycle_Homo sapiens_hsa041100.48420767
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48384976
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46261965
130Vitamin B6 metabolism_Homo sapiens_hsa007500.45753391
131Melanoma_Homo sapiens_hsa052180.44220841
132Rap1 signaling pathway_Homo sapiens_hsa040150.44181990
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43629523
134Glycerolipid metabolism_Homo sapiens_hsa005610.42624616
135TGF-beta signaling pathway_Homo sapiens_hsa043500.42363111
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42220951
137Metabolic pathways_Homo sapiens_hsa011000.42018665
138Hippo signaling pathway_Homo sapiens_hsa043900.41847346
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.40754337
140Vibrio cholerae infection_Homo sapiens_hsa051100.40384469
141Prolactin signaling pathway_Homo sapiens_hsa049170.40101661
142Histidine metabolism_Homo sapiens_hsa003400.39990107
143Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38616712
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38040861
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35372890
146Fanconi anemia pathway_Homo sapiens_hsa034600.34986791
147Fatty acid biosynthesis_Homo sapiens_hsa000610.34899725
148Thyroid cancer_Homo sapiens_hsa052160.33362959
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33107803
150mTOR signaling pathway_Homo sapiens_hsa041500.31477961
151Tight junction_Homo sapiens_hsa045300.30988651
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30809857
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.30118988
154Adherens junction_Homo sapiens_hsa045200.29760137

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