NEK11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.51771656
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.87015509
3axoneme assembly (GO:0035082)8.58409184
4sperm motility (GO:0030317)7.12342438
5fusion of sperm to egg plasma membrane (GO:0007342)6.91056633
6ventricular system development (GO:0021591)6.76536632
7multicellular organism reproduction (GO:0032504)6.59926210
8cell wall macromolecule catabolic process (GO:0016998)6.23524846
9cell wall macromolecule metabolic process (GO:0044036)6.23524846
10piRNA metabolic process (GO:0034587)6.11605279
11intraciliary transport (GO:0042073)6.11244870
12regulation of cilium movement (GO:0003352)5.96346260
13sperm-egg recognition (GO:0035036)5.75417557
14acrosome reaction (GO:0007340)5.72894169
15acrosome assembly (GO:0001675)5.72534348
16protein localization to cilium (GO:0061512)5.43994105
17spermatid development (GO:0007286)5.35955781
18plasma membrane fusion (GO:0045026)5.29024355
19GTP biosynthetic process (GO:0006183)5.24415864
20cilium organization (GO:0044782)5.16857046
21left/right axis specification (GO:0070986)5.15050179
22cell-cell recognition (GO:0009988)5.10619999
23reproduction (GO:0000003)5.09354277
24cilium assembly (GO:0042384)5.04764406
25nucleoside diphosphate phosphorylation (GO:0006165)4.95883393
26binding of sperm to zona pellucida (GO:0007339)4.88572616
27male meiosis (GO:0007140)4.83777793
28single fertilization (GO:0007338)4.71284289
29cilium morphogenesis (GO:0060271)4.59839546
30centriole assembly (GO:0098534)4.42613173
31UTP biosynthetic process (GO:0006228)4.31473486
32cellular component assembly involved in morphogenesis (GO:0010927)4.27076586
33sperm capacitation (GO:0048240)4.24245072
34centriole replication (GO:0007099)4.18784862
35microtubule severing (GO:0051013)4.16616902
36primary alcohol catabolic process (GO:0034310)4.14130619
37male meiosis I (GO:0007141)4.14113655
38DNA methylation involved in gamete generation (GO:0043046)3.99407455
39glomerular epithelial cell development (GO:0072310)3.98728341
40establishment of tissue polarity (GO:0007164)3.93603921
41establishment of planar polarity (GO:0001736)3.93603921
42synaptonemal complex organization (GO:0070193)3.87784834
43guanosine-containing compound biosynthetic process (GO:1901070)3.83323156
44microtubule bundle formation (GO:0001578)3.81877698
45vitamin transmembrane transport (GO:0035461)3.77770014
46lung epithelium development (GO:0060428)3.74867589
47spermatogenesis (GO:0007283)3.70605715
48UTP metabolic process (GO:0046051)3.69594971
49male gamete generation (GO:0048232)3.69243389
50fertilization (GO:0009566)3.68080266
51diterpenoid biosynthetic process (GO:0016102)3.64324902
52ethanol metabolic process (GO:0006067)3.59751224
53positive regulation of smoothened signaling pathway (GO:0045880)3.58720969
54negative regulation of inclusion body assembly (GO:0090084)3.57488852
55meiotic cell cycle (GO:0051321)3.55575143
56microtubule-based movement (GO:0007018)3.52118630
57protein polyglutamylation (GO:0018095)3.49926513
58myoblast migration (GO:0051451)3.48391652
59gamete generation (GO:0007276)3.43814925
60response to xenobiotic stimulus (GO:0009410)3.34959243
61cell projection assembly (GO:0030031)3.34421479
62retinal rod cell development (GO:0046548)3.22364869
63nonmotile primary cilium assembly (GO:0035058)3.20875786
64CTP biosynthetic process (GO:0006241)3.19576624
65CTP metabolic process (GO:0046036)3.19576624
66histone H4-K12 acetylation (GO:0043983)3.18890981
67meiosis I (GO:0007127)3.16945737
68pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.16379843
69calcium ion-dependent exocytosis (GO:0017156)3.14605674
70apical protein localization (GO:0045176)3.10224169
71lateral sprouting from an epithelium (GO:0060601)3.09703907
72synaptonemal complex assembly (GO:0007130)3.08059135
73microtubule depolymerization (GO:0007019)3.06529015
74spermatid nucleus differentiation (GO:0007289)3.06212605
75left/right pattern formation (GO:0060972)3.05437865
76asymmetric protein localization (GO:0008105)3.04148929
77regulation of microtubule-based movement (GO:0060632)3.03943033
78pyrimidine-containing compound transmembrane transport (GO:0072531)2.98566248
79smoothened signaling pathway (GO:0007224)2.97912482
80establishment of apical/basal cell polarity (GO:0035089)2.95610391
81lateral ventricle development (GO:0021670)2.95337478
82superoxide anion generation (GO:0042554)2.90513582
83cytoplasmic microtubule organization (GO:0031122)2.89239106
84meiotic nuclear division (GO:0007126)2.88366680
85regulation of interleukin-5 production (GO:0032674)2.87646108
86negative regulation of T cell differentiation in thymus (GO:0033085)2.82911881
87regulation of smoothened signaling pathway (GO:0008589)2.82314558
88germ cell development (GO:0007281)2.82131920
89nucleotide phosphorylation (GO:0046939)2.81681090
90cellular process involved in reproduction in multicellular organism (GO:0022412)2.80363422
91fatty acid elongation (GO:0030497)2.76720257
92establishment of monopolar cell polarity (GO:0061162)2.74851812
93establishment or maintenance of monopolar cell polarity (GO:0061339)2.74851812
94cell recognition (GO:0008037)2.73135430
95microtubule polymerization or depolymerization (GO:0031109)2.72149565
96regulation of inclusion body assembly (GO:0090083)2.69675842
97terpenoid biosynthetic process (GO:0016114)2.68758301
98nucleoside diphosphate metabolic process (GO:0009132)2.68423141
99ethanol oxidation (GO:0006069)2.67966026
100retinoic acid metabolic process (GO:0042573)2.65905213
101microtubule-based process (GO:0007017)2.65610825
102pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.65074830
103multicellular organismal reproductive process (GO:0048609)2.64304550
104regulation of collateral sprouting (GO:0048670)2.63902941
105negative regulation of humoral immune response (GO:0002921)2.63712670
106muscle cell migration (GO:0014812)2.63002094
107chromosome organization involved in meiosis (GO:0070192)2.56560974
108pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.55882143
109deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.54394540
110negative regulation of JUN kinase activity (GO:0043508)2.51827545
111carnitine metabolic process (GO:0009437)2.51714667
112one-carbon compound transport (GO:0019755)2.50027833
113response to gravity (GO:0009629)2.48611983
114dentate gyrus development (GO:0021542)2.47752994
115determination of left/right symmetry (GO:0007368)2.47297547
116organic cation transport (GO:0015695)2.46790848
117regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.44657334
118organelle assembly (GO:0070925)2.44370194
119response to pheromone (GO:0019236)2.43764508
120sensory perception of smell (GO:0007608)2.37754173
121regulation of interleukin-13 production (GO:0032656)2.37314713
122glutathione derivative biosynthetic process (GO:1901687)2.36795369
123glutathione derivative metabolic process (GO:1901685)2.36795369
124establishment of nucleus localization (GO:0040023)2.32625212
125determination of bilateral symmetry (GO:0009855)2.32386273
126cornea development in camera-type eye (GO:0061303)2.31660938
127photoreceptor cell maintenance (GO:0045494)2.29577779
128nephron tubule formation (GO:0072079)2.29367648
129regulation of male gonad development (GO:2000018)2.29349585
130pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.29065859
131specification of symmetry (GO:0009799)2.27476276
132retinol metabolic process (GO:0042572)2.27414410
133renal system development (GO:0072001)2.27301381
134negative regulation of B cell mediated immunity (GO:0002713)2.27056192
135negative regulation of immunoglobulin mediated immune response (GO:0002890)2.27056192
136positive regulation of meiosis (GO:0045836)2.26661402
137excretion (GO:0007588)2.26071627
138synapsis (GO:0007129)2.22283787
139cellular response to gamma radiation (GO:0071480)2.21016390
140heart looping (GO:0001947)2.20269013
141negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.17430361
142regulation of germinal center formation (GO:0002634)2.17175393
143regulation of mesenchymal cell apoptotic process (GO:2001053)2.16449682
144eye photoreceptor cell differentiation (GO:0001754)2.16322396
145photoreceptor cell differentiation (GO:0046530)2.16322396
146appendage development (GO:0048736)2.15126075
147limb development (GO:0060173)2.15126075
148metanephric mesenchyme development (GO:0072075)2.13817874
149regulation of posttranscriptional gene silencing (GO:0060147)2.13309598
150regulation of gene silencing by miRNA (GO:0060964)2.13309598
151regulation of gene silencing by RNA (GO:0060966)2.13309598
152embryonic heart tube morphogenesis (GO:0003143)2.13304372
153tolerance induction (GO:0002507)2.12108395
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.11341756
155cilium or flagellum-dependent cell motility (GO:0001539)13.7240260
156axonemal dynein complex assembly (GO:0070286)13.1325012
157cilium movement (GO:0003341)11.4985467
158epithelial cilium movement (GO:0003351)10.0249233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.59301117
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.55739028
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.34386754
4GBX2_23144817_ChIP-Seq_PC3_Human2.91588121
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.70649143
6PCGF2_27294783_Chip-Seq_ESCs_Mouse2.68158053
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64369628
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.60687960
9DROSHA_22980978_ChIP-Seq_HELA_Human2.59388049
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57935982
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.44903505
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.36957177
13PCGF2_27294783_Chip-Seq_NPCs_Mouse2.17732791
14ESR1_20079471_ChIP-ChIP_T-47D_Human2.13748326
15SUZ12_27294783_Chip-Seq_NPCs_Mouse2.10430994
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.04694576
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.03954072
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.01326554
19NFE2_27457419_Chip-Seq_LIVER_Mouse2.00510984
20TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.97806166
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96018931
22AHR_22903824_ChIP-Seq_MCF-7_Human1.94550620
23EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.88001721
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87177242
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.85031256
26P53_22387025_ChIP-Seq_ESCs_Mouse1.79833276
27ARNT_22903824_ChIP-Seq_MCF-7_Human1.79789294
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79279167
29RNF2_27304074_Chip-Seq_NSC_Mouse1.78982153
30IGF1R_20145208_ChIP-Seq_DFB_Human1.78715309
31TP53_18474530_ChIP-ChIP_U2OS_Human1.78026356
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77793583
33AR_21572438_ChIP-Seq_LNCaP_Human1.75548751
34STAT3_18555785_Chip-Seq_ESCs_Mouse1.74665874
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73359842
36* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72768136
37FOXM1_26456572_ChIP-Seq_MCF-7_Human1.71534781
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.70441286
39FUS_26573619_Chip-Seq_HEK293_Human1.69259419
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.69032777
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.67791026
42SUZ12_18555785_Chip-Seq_ESCs_Mouse1.66656817
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.65357358
44EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.61666858
45CMYC_18555785_Chip-Seq_ESCs_Mouse1.60211993
46* P300_19829295_ChIP-Seq_ESCs_Human1.59389928
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.59247273
48P300_18555785_Chip-Seq_ESCs_Mouse1.57505758
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.56548418
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.53900163
51NMYC_18555785_Chip-Seq_ESCs_Mouse1.53765713
52TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51860644
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.51860644
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.49562189
55CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46694855
56* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45500038
57TP53_16413492_ChIP-PET_HCT116_Human1.45269516
58PU1_27457419_Chip-Seq_LIVER_Mouse1.44324043
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.43762955
60CRX_20693478_ChIP-Seq_RETINA_Mouse1.43638214
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.43582468
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42266314
63RUNX1_27457419_Chip-Seq_LIVER_Mouse1.41720924
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40993592
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40945819
66KLF4_18555785_Chip-Seq_ESCs_Mouse1.40202525
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.38318038
68* REST_21632747_ChIP-Seq_MESCs_Mouse1.37333905
69ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36939602
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35979795
71KDM2B_26808549_Chip-Seq_REH_Human1.32774316
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32309998
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31809958
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29941794
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29655113
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26982730
77CTCF_18555785_Chip-Seq_ESCs_Mouse1.26712051
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25950765
79* STAT3_23295773_ChIP-Seq_U87_Human1.25783497
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.25194747
81SMAD1_18555785_Chip-Seq_ESCs_Mouse1.24878739
82* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24764925
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24570016
84VDR_22108803_ChIP-Seq_LS180_Human1.24510198
85ER_23166858_ChIP-Seq_MCF-7_Human1.23877200
86WDR5_24793694_ChIP-Seq_LNCAP_Human1.23760789
87* TP63_23658742_ChIP-Seq_EP156T_Human1.23097660
88TAF15_26573619_Chip-Seq_HEK293_Human1.23004505
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.22954440
90* TCF4_23295773_ChIP-Seq_U87_Human1.22704212
91CBP_20019798_ChIP-Seq_JUKART_Human1.22563810
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22563810
93* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21822090
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.21248456
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20820098
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20645202
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20112475
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19993674
99STAT1_17558387_ChIP-Seq_HELA_Human1.19131777
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19077820
101TBL1_22424771_ChIP-Seq_293T_Human1.18291022
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18195478
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.17319645
104EED_16625203_ChIP-ChIP_MESCs_Mouse1.16894920
105TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16191941
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.16045669
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14684788
108AR_25329375_ChIP-Seq_VCAP_Human1.14634308
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.14287499
110SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14281922
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.13291660
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12932326
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12803915
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12653882
115ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11804450
116ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11128832
117PHF8_20622853_ChIP-Seq_HELA_Human1.11094130
118LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10245807
119SMAD3_21741376_ChIP-Seq_HESCs_Human1.10044307
120GATA1_26923725_Chip-Seq_HPCs_Mouse1.09803813
121* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09022638
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08554499
123EZH2_27304074_Chip-Seq_ESCs_Mouse1.07558759
124FLI1_21867929_ChIP-Seq_TH2_Mouse1.06886816
125PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06863124
126SOX9_26525672_Chip-Seq_HEART_Mouse1.06818000
127SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05725628
128CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.05111253
129SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.04973067
130* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04867494
131* BCAT_22108803_ChIP-Seq_LS180_Human1.04335091
132HNFA_21074721_ChIP-Seq_CACO-2_Human1.03920441
133SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03907923
134* AR_19668381_ChIP-Seq_PC3_Human1.03880497
135* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03542744
136STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03108738
137* TCF4_22108803_ChIP-Seq_LS180_Human1.03014799
138ETV1_20927104_ChIP-Seq_GIST48_Human1.02690728
139SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02438647
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.02282082
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01870151
142RUNX2_22187159_ChIP-Seq_PCA_Human1.01544793
143ESR1_21235772_ChIP-Seq_MCF-7_Human1.01344771
144NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01032295
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00996134
146ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00891989
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99970688
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.99059446
149CJUN_26792858_Chip-Seq_BT549_Human0.98394812
150NFYA_21822215_ChIP-Seq_K562_Human0.97814989
151SMAD4_21741376_ChIP-Seq_EPCs_Human0.97730511
152JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97593040
153AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96665434
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96555880
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96555880
156NFYB_21822215_ChIP-Seq_K562_Human0.96243296
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.94093629
158FOXA1_25552417_ChIP-Seq_VCAP_Human0.93704969
159SMAD4_21741376_ChIP-Seq_HESCs_Human0.93379456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.25845758
2MP0003136_yellow_coat_color3.75179706
3MP0008875_abnormal_xenobiotic_pharmacok3.69775101
4MP0001984_abnormal_olfaction3.39578788
5MP0002653_abnormal_ependyma_morphology3.29168795
6MP0000383_abnormal_hair_follicle3.10410178
7MP0003698_abnormal_male_reproductive3.06682190
8MP0008004_abnormal_stomach_pH3.05797354
9MP0001929_abnormal_gametogenesis2.81290641
10MP0005646_abnormal_pituitary_gland2.80336692
11MP0001188_hyperpigmentation2.70455370
12MP0004043_abnormal_pH_regulation2.64280344
13MP0002638_abnormal_pupillary_reflex2.59141674
14MP0002928_abnormal_bile_duct2.46590593
15MP0010678_abnormal_skin_adnexa2.42469307
16MP0002163_abnormal_gland_morphology2.39989720
17MP0006292_abnormal_olfactory_placode2.33512908
18MP0002160_abnormal_reproductive_system2.32063281
19MP0008877_abnormal_DNA_methylation2.30709606
20MP0005645_abnormal_hypothalamus_physiol2.23894072
21MP0002210_abnormal_sex_determination2.23506511
22MP0005379_endocrine/exocrine_gland_phen2.15598420
23MP0001502_abnormal_circadian_rhythm1.99013784
24MP0010386_abnormal_urinary_bladder1.87550372
25MP0010030_abnormal_orbit_morphology1.84191811
26MP0004782_abnormal_surfactant_physiolog1.80526515
27MP0003878_abnormal_ear_physiology1.77120467
28MP0005377_hearing/vestibular/ear_phenot1.77120467
29MP0002138_abnormal_hepatobiliary_system1.76531681
30MP0004019_abnormal_vitamin_homeostasis1.73580773
31MP0000566_synostosis1.69398734
32MP0002736_abnormal_nociception_after1.64456691
33MP0002161_abnormal_fertility/fecundity1.57863651
34MP0001145_abnormal_male_reproductive1.55468435
35MP0000372_irregular_coat_pigmentation1.54914162
36MP0005551_abnormal_eye_electrophysiolog1.54409387
37MP0003879_abnormal_hair_cell1.48984131
38MP0004742_abnormal_vestibular_system1.48850696
39MP0004133_heterotaxia1.46453712
40MP0000653_abnormal_sex_gland1.45962552
41MP0003283_abnormal_digestive_organ1.44473463
42MP0008058_abnormal_DNA_repair1.42397684
43MP0008789_abnormal_olfactory_epithelium1.41866421
44MP0005171_absent_coat_pigmentation1.41141974
45MP0005389_reproductive_system_phenotype1.41098905
46MP0001299_abnormal_eye_distance/1.40331682
47MP0003787_abnormal_imprinting1.28402915
48MP0002249_abnormal_larynx_morphology1.26410205
49MP0000778_abnormal_nervous_system1.25493525
50MP0002282_abnormal_trachea_morphology1.25336569
51MP0005503_abnormal_tendon_morphology1.25129965
52MP0002234_abnormal_pharynx_morphology1.24173202
53MP0005253_abnormal_eye_physiology1.22239204
54MP0001529_abnormal_vocalization1.22017079
55MP0002102_abnormal_ear_morphology1.21196158
56MP0005423_abnormal_somatic_nervous1.20445445
57MP0000026_abnormal_inner_ear1.20236998
58MP0002735_abnormal_chemical_nociception1.18668776
59MP0005394_taste/olfaction_phenotype1.18186823
60MP0005499_abnormal_olfactory_system1.18186823
61MP0002938_white_spotting1.18177356
62MP0009046_muscle_twitch1.16866991
63MP0009697_abnormal_copulation1.15793802
64MP0001346_abnormal_lacrimal_gland1.15669480
65MP0002557_abnormal_social/conspecific_i1.12808100
66MP0002909_abnormal_adrenal_gland1.10737765
67MP0001968_abnormal_touch/_nociception1.10621233
68MP0000631_abnormal_neuroendocrine_gland1.10581629
69MP0002132_abnormal_respiratory_system1.10467326
70MP0003937_abnormal_limbs/digits/tail_de1.10085334
71MP0004885_abnormal_endolymph1.09770025
72MP0005075_abnormal_melanosome_morpholog1.09724029
73MP0002876_abnormal_thyroid_physiology1.08913922
74MP0002734_abnormal_mechanical_nocicepti1.08611585
75MP0000015_abnormal_ear_pigmentation1.07941471
76MP0002168_other_aberrant_phenotype1.06075454
77MP0001293_anophthalmia1.06037818
78MP0001970_abnormal_pain_threshold1.01992206
79MP0004883_abnormal_blood_vessel1.00982176
80MP0006276_abnormal_autonomic_nervous1.00949378
81MP0000955_abnormal_spinal_cord0.99860608
82MP0004381_abnormal_hair_follicle0.97652767
83MP0005248_abnormal_Harderian_gland0.97304773
84MP0000762_abnormal_tongue_morphology0.96469264
85MP0005670_abnormal_white_adipose0.94654988
86MP0002572_abnormal_emotion/affect_behav0.93742547
87MP0008057_abnormal_DNA_replication0.93713856
88MP0001765_abnormal_ion_homeostasis0.93625176
89MP0005647_abnormal_sex_gland0.93602730
90MP0002896_abnormal_bone_mineralization0.93157510
91MP0004270_analgesia0.92971922
92MP0000049_abnormal_middle_ear0.92246197
93MP0000538_abnormal_urinary_bladder0.90326288
94MP0003942_abnormal_urinary_system0.90100092
95MP0002116_abnormal_craniofacial_bone0.89982976
96MP0005195_abnormal_posterior_eye0.89339454
97MP0009745_abnormal_behavioral_response0.89267706
98MP0004134_abnormal_chest_morphology0.89143300
99MP0006072_abnormal_retinal_apoptosis0.88772861
100MP0001119_abnormal_female_reproductive0.88229034
101MP0001486_abnormal_startle_reflex0.87572327
102MP0003950_abnormal_plasma_membrane0.86651222
103MP0008995_early_reproductive_senescence0.86200569
104MP0001963_abnormal_hearing_physiology0.85801889
105MP0001879_abnormal_lymphatic_vessel0.84969778
106MP0002067_abnormal_sensory_capabilities0.84530186
107MP0001485_abnormal_pinna_reflex0.82618422
108MP0000569_abnormal_digit_pigmentation0.81398529
109MP0002184_abnormal_innervation0.81096363
110MP0002277_abnormal_respiratory_mucosa0.80165792
111MP0009780_abnormal_chondrocyte_physiolo0.79905509
112MP0002752_abnormal_somatic_nervous0.79215190
113MP0003880_abnormal_central_pattern0.79093091
114MP0002693_abnormal_pancreas_physiology0.78146978
115MP0002063_abnormal_learning/memory/cond0.77838780
116MP0008260_abnormal_autophagy0.77331231
117MP0001177_atelectasis0.76305821
118MP0005257_abnormal_intraocular_pressure0.74336799
119MP0005164_abnormal_response_to0.73565078
120MP0002229_neurodegeneration0.72361736
121MP0001986_abnormal_taste_sensitivity0.72355808
122MP0003755_abnormal_palate_morphology0.70108989
123MP0003635_abnormal_synaptic_transmissio0.69425079
124MP0001905_abnormal_dopamine_level0.69368291
125MP0006082_CNS_inflammation0.69170899
126MP0003938_abnormal_ear_development0.67716086
127MP0002148_abnormal_hypersensitivity_rea0.66450545
128MP0003634_abnormal_glial_cell0.66205782
129MP0002233_abnormal_nose_morphology0.65720665
130MP0000613_abnormal_salivary_gland0.65679321
131MP0005623_abnormal_meninges_morphology0.65202926
132MP0000534_abnormal_ureter_morphology0.65047052
133MP0005391_vision/eye_phenotype0.63028453
134MP0002272_abnormal_nervous_system0.62284106
135MP0003861_abnormal_nervous_system0.60881112
136MP0002064_seizures0.60671953
137MP0001324_abnormal_eye_pigmentation0.59900067
138MP0001440_abnormal_grooming_behavior0.59802874
139MP0002882_abnormal_neuron_morphology0.59544287
140MP0003633_abnormal_nervous_system0.59378915
141MP0005388_respiratory_system_phenotype0.58957368
142MP0002133_abnormal_respiratory_system0.58957368
143MP0004859_abnormal_synaptic_plasticity0.58853335
144MP0004142_abnormal_muscle_tone0.58785362
145MP0000432_abnormal_head_morphology0.58473922
146MP0002152_abnormal_brain_morphology0.58457523
147MP0002822_catalepsy0.58306598
148MP0001919_abnormal_reproductive_system0.58146597
149MP0000470_abnormal_stomach_morphology0.57516983
150MP0010368_abnormal_lymphatic_system0.56871327
151MP0000427_abnormal_hair_cycle0.56866838

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.38333607
2Absent/shortened dynein arms (HP:0200106)8.79169506
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.79169506
4Abnormal respiratory motile cilium morphology (HP:0005938)8.41702793
5Abnormal respiratory epithelium morphology (HP:0012253)8.41702793
6Rhinitis (HP:0012384)8.28750435
7Chronic bronchitis (HP:0004469)5.92993573
8Bronchiectasis (HP:0002110)5.05276985
9True hermaphroditism (HP:0010459)4.26246262
10Medial flaring of the eyebrow (HP:0010747)4.11434647
11Nasal polyposis (HP:0100582)4.06674387
12Infertility (HP:0000789)4.00963101
13Nephronophthisis (HP:0000090)3.81308109
14Pancreatic fibrosis (HP:0100732)3.65605647
15Congenital primary aphakia (HP:0007707)3.61403810
16Gait imbalance (HP:0002141)3.60835154
17Nephrogenic diabetes insipidus (HP:0009806)3.38696705
18Bronchitis (HP:0012387)3.25457676
19Tubulointerstitial nephritis (HP:0001970)3.22513058
20Recurrent sinusitis (HP:0011108)3.22366762
21Molar tooth sign on MRI (HP:0002419)3.11088896
22Abnormality of midbrain morphology (HP:0002418)3.11088896
23Abnormality of the nasal mucosa (HP:0000433)3.11087540
24Abnormality of the renal medulla (HP:0100957)3.08717071
25Chronic sinusitis (HP:0011109)3.04829165
26Pancreatic cysts (HP:0001737)3.00417568
27Occipital encephalocele (HP:0002085)2.92784797
28Poor coordination (HP:0002370)2.83420258
29Postaxial foot polydactyly (HP:0001830)2.82058027
30Vaginal atresia (HP:0000148)2.66687899
31Genital tract atresia (HP:0001827)2.66031080
32Cystic liver disease (HP:0006706)2.60810610
33Median cleft lip (HP:0000161)2.58044659
34Congenital hepatic fibrosis (HP:0002612)2.55311106
35Bell-shaped thorax (HP:0001591)2.55046470
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.54888692
37Chronic hepatic failure (HP:0100626)2.42650821
38Recurrent otitis media (HP:0000403)2.37631595
39Chronic otitis media (HP:0000389)2.34290724
40Male infertility (HP:0003251)2.33981035
41Postaxial hand polydactyly (HP:0001162)2.33628052
42Bile duct proliferation (HP:0001408)2.32760227
43Abnormal biliary tract physiology (HP:0012439)2.32760227
44Hyperactive renin-angiotensin system (HP:0000841)2.21205059
45Aplasia/Hypoplasia of the lens (HP:0008063)2.20390531
46Preaxial hand polydactyly (HP:0001177)2.14917063
47Male pseudohermaphroditism (HP:0000037)2.05943151
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.9211794
49Abnormal respiratory motile cilium physiology (HP:0012261)10.0096406
50Fibular hypoplasia (HP:0003038)1.99244320
51Facial cleft (HP:0002006)1.98952311
52Polydipsia (HP:0001959)1.97011798
53Abnormal drinking behavior (HP:0030082)1.97011798
54Abnormality of permanent molar morphology (HP:0011071)1.96648814
55Abnormality of the dental root (HP:0006486)1.96648814
56Taurodontia (HP:0000679)1.96648814
57Stage 5 chronic kidney disease (HP:0003774)1.95474696
58Tubulointerstitial abnormality (HP:0001969)1.94145736
59Supernumerary spleens (HP:0009799)1.90394670
60Abnormality of molar morphology (HP:0011070)1.90184027
61Abnormality of molar (HP:0011077)1.90184027
62Furrowed tongue (HP:0000221)1.89496261
63Bifid tongue (HP:0010297)1.84532455
64Hypothermia (HP:0002045)1.82013633
65Abnormality of the dental pulp (HP:0006479)1.80941023
66Sclerocornea (HP:0000647)1.78736183
67Anencephaly (HP:0002323)1.78350760
68Decreased central vision (HP:0007663)1.76667377
69Tubular atrophy (HP:0000092)1.75455116
70Abnormal hair whorl (HP:0010721)1.72863855
71Broad foot (HP:0001769)1.71582586
72Absent frontal sinuses (HP:0002688)1.62948273
73Oculomotor apraxia (HP:0000657)1.62694104
74Aganglionic megacolon (HP:0002251)1.62195896
75Optic nerve hypoplasia (HP:0000609)1.60883299
76Chromosomal breakage induced by crosslinking agents (HP:0003221)1.60825970
77Nephropathy (HP:0000112)1.60199597
78Abnormality of the renal cortex (HP:0011035)1.58926267
79Astigmatism (HP:0000483)1.58696359
80Febrile seizures (HP:0002373)1.57023176
81Abnormality of dentin (HP:0010299)1.54149055
82Specific learning disability (HP:0001328)1.53725622
83Abnormality of the fovea (HP:0000493)1.51780811
84Asplenia (HP:0001746)1.51611524
85Aplasia/Hypoplasia of the spleen (HP:0010451)1.49956135
86Abnormality of macular pigmentation (HP:0008002)1.49625239
87Abnormality of abdominal situs (HP:0011620)1.49204451
88Abdominal situs inversus (HP:0003363)1.49204451
89Aplasia/Hypoplasia of the fovea (HP:0008060)1.48781960
90Hypoplasia of the fovea (HP:0007750)1.48781960
91Decreased circulating renin level (HP:0003351)1.47899356
92Short foot (HP:0001773)1.47868861
93Renal dysplasia (HP:0000110)1.47160675
94Recurrent bronchitis (HP:0002837)1.47100411
95Septo-optic dysplasia (HP:0100842)1.46772491
96Retinal dysplasia (HP:0007973)1.45065499
97Bony spicule pigmentary retinopathy (HP:0007737)1.44749416
98Retinitis pigmentosa (HP:0000510)1.41827729
99Short thorax (HP:0010306)1.40753435
100Glucose intolerance (HP:0000833)1.36921366
101Abnormal spermatogenesis (HP:0008669)1.36836111
102Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.35999675
103Narrow forehead (HP:0000341)1.34425157
104Decreased testicular size (HP:0008734)1.34260014
105Intellectual disability, moderate (HP:0002342)1.33644740
106Anophthalmia (HP:0000528)1.32423025
107Short nail (HP:0001799)1.31779718
108Dental crowding (HP:0000678)1.31591759
109Left ventricular hypertrophy (HP:0001712)1.31312971
110Chromsome breakage (HP:0040012)1.30712082
111Hyperkalemia (HP:0002153)1.30678648
112Papillary thyroid carcinoma (HP:0002895)1.30608242
113Atelectasis (HP:0100750)1.29965720
114Azoospermia (HP:0000027)1.29743554
115Hyperaldosteronism (HP:0000859)1.29181286
116Prostate neoplasm (HP:0100787)1.28411144
117Asthma (HP:0002099)1.26683125
118Severe visual impairment (HP:0001141)1.25953081
119Renal salt wasting (HP:0000127)1.25186964
120Tubulointerstitial fibrosis (HP:0005576)1.24809336
121Polyuria (HP:0000103)1.22480878
122Prominent nasal bridge (HP:0000426)1.20493146
123Bifid scrotum (HP:0000048)1.13961291
124Highly arched eyebrow (HP:0002553)1.12967964
125Abnormal rod and cone electroretinograms (HP:0008323)1.11693361
126Optic nerve coloboma (HP:0000588)1.11517246
127Abnormality of the frontal sinuses (HP:0002687)1.10845670
128Abnormality of renal excretion (HP:0011036)1.10315636
129Fetal akinesia sequence (HP:0001989)1.10303006
130Full cheeks (HP:0000293)1.09408921
131Abnormality of renin-angiotensin system (HP:0000847)1.06415539
132Long face (HP:0000276)1.03676328
133Popliteal pterygium (HP:0009756)1.03459315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK44.16418930
2PDK34.16418930
3CASK3.20759519
4MAPK153.15448520
5EPHA23.04087948
6PRKD32.64856230
7ERBB32.59713367
8ZAK2.52131568
9PDK22.36739358
10TNIK2.24357701
11MAPK132.19977146
12TESK12.18978703
13SIK32.06882350
14PASK2.00551386
15IRAK41.98740945
16GRK11.76226396
17MAPKAPK31.75632824
18IRAK11.73706749
19AKT31.71338508
20TAF11.67738027
21YES11.66657037
22BRD41.65405849
23MAP2K71.65322402
24IRAK21.58128078
25PLK41.57881266
26BMPR21.57328617
27MUSK1.51779967
28MET1.49644142
29STK161.46350802
30NEK61.45079333
31LMTK21.43121372
32TSSK61.38445320
33NTRK21.36126253
34NLK1.32296633
35BCR1.31483893
36PLK21.28515269
37PINK11.27690601
38SGK21.27260071
39ILK1.27064403
40WNK41.26475460
41STK38L1.26458656
42BMPR1B1.25636883
43MAP3K21.25287568
44FRK1.23004988
45PTK21.22327275
46LRRK21.20643393
47EIF2AK21.19927322
48TXK1.18784997
49EPHA31.17870747
50PBK1.17704866
51EPHA41.17362041
52PTK2B1.14587785
53EPHB11.03632798
54CDK31.02462771
55PRKCI1.01051090
56KSR10.98610604
57NME10.98586843
58ADRBK20.98578108
59LATS10.96952389
60MST1R0.96640010
61WEE10.93506676
62STK390.92587253
63NUAK10.92402868
64VRK10.90571895
65SGK4940.88250703
66SGK2230.88250703
67MAP3K140.86935101
68TNK20.85157704
69CCNB10.84853799
70PRKCG0.84705874
71RIPK10.84498756
72TRPM70.80382898
73DAPK20.78991645
74DYRK20.78961910
75JAK30.77012251
76PNCK0.76082441
77MARK10.75227556
78FGFR20.74831336
79BRSK20.73329442
80DYRK30.73151489
81BRAF0.71870571
82INSRR0.69166331
83PRKCE0.68317048
84CHEK20.68171556
85CDK80.67541580
86MAP3K40.67304335
87MKNK20.66322206
88ERBB20.64086065
89DYRK1A0.63653547
90NTRK30.63541097
91MAP2K40.63465954
92ROCK10.63444567
93PRPF4B0.60344315
94EIF2AK30.58903676
95CHUK0.55181698
96FER0.54886208
97ATR0.52929581
98TTK0.52900166
99ROCK20.52046106
100STK100.52034816
101MARK30.49964893
102TEC0.49260766
103SGK10.49111331
104NEK90.48734285
105CDC42BPA0.48125215
106CAMK2G0.47995189
107MAP3K70.47294117
108ERBB40.45922955
109GRK70.45818420
110WNK30.45253338
111PRKCQ0.42748678
112PRKG10.42291073
113RPS6KA20.41238033
114MST40.41082862
115PIK3CG0.40761729
116RET0.39438306
117PDGFRB0.39335119
118RPS6KB10.39037658
119PLK30.37943757
120CSK0.37908330
121PRKCZ0.37135496
122PIM20.35772833
123CAMK2A0.35764103
124EPHB20.35583476
125MAP3K120.35142587
126SGK30.33781674
127IKBKE0.33541459
128WNK10.32655658
129STK240.32527909
130PIM10.31802147
131PHKG20.31732148
132PHKG10.31732148
133STK380.30472278
134ADRBK10.29593782
135NTRK10.29005084
136PRKCD0.28725579
137MAP3K30.28256018
138PLK10.26801925
139MYLK0.26534672
140PRKACA0.26363009
141MAP2K10.26331207
142HIPK20.26075118
143ABL20.24742401
144CAMKK10.24523296
145CAMK1G0.22682487
146STK110.21703802
147MAPKAPK50.21133950

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.84407316
2Histidine metabolism_Homo sapiens_hsa003403.60476138
3Olfactory transduction_Homo sapiens_hsa047403.36483822
4Chemical carcinogenesis_Homo sapiens_hsa052043.10627054
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.10548931
6Phenylalanine metabolism_Homo sapiens_hsa003602.88166539
7Collecting duct acid secretion_Homo sapiens_hsa049662.69762711
8Fanconi anemia pathway_Homo sapiens_hsa034602.58430297
9Basal transcription factors_Homo sapiens_hsa030222.51944605
10Nicotine addiction_Homo sapiens_hsa050332.51037676
11Tyrosine metabolism_Homo sapiens_hsa003502.36277445
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.20845281
13beta-Alanine metabolism_Homo sapiens_hsa004102.18231268
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.10514058
15Synaptic vesicle cycle_Homo sapiens_hsa047212.07817446
16Glutathione metabolism_Homo sapiens_hsa004801.94839933
17Insulin secretion_Homo sapiens_hsa049111.90442683
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.89718506
19Rheumatoid arthritis_Homo sapiens_hsa053231.82666062
20Phototransduction_Homo sapiens_hsa047441.75280861
21Graft-versus-host disease_Homo sapiens_hsa053321.71076167
22Morphine addiction_Homo sapiens_hsa050321.60461875
23Vibrio cholerae infection_Homo sapiens_hsa051101.60158356
24Type I diabetes mellitus_Homo sapiens_hsa049401.58720431
25Amphetamine addiction_Homo sapiens_hsa050311.58129516
26Circadian entrainment_Homo sapiens_hsa047131.58090135
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57821131
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.57519719
29Caffeine metabolism_Homo sapiens_hsa002321.54647421
30Tight junction_Homo sapiens_hsa045301.53328994
31Circadian rhythm_Homo sapiens_hsa047101.50514001
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46618199
33Huntingtons disease_Homo sapiens_hsa050161.44577215
34Retinol metabolism_Homo sapiens_hsa008301.40994942
35Purine metabolism_Homo sapiens_hsa002301.38291073
36Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.33531156
37Allograft rejection_Homo sapiens_hsa053301.33093432
38Homologous recombination_Homo sapiens_hsa034401.31262758
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.30095055
40Phagosome_Homo sapiens_hsa041451.29820496
41Autoimmune thyroid disease_Homo sapiens_hsa053201.29323666
42Vitamin B6 metabolism_Homo sapiens_hsa007501.24825921
43ABC transporters_Homo sapiens_hsa020101.20947246
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16834446
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13892670
46Taste transduction_Homo sapiens_hsa047421.12806228
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12020975
48Inositol phosphate metabolism_Homo sapiens_hsa005621.09239564
49Glutamatergic synapse_Homo sapiens_hsa047241.08420422
50Non-homologous end-joining_Homo sapiens_hsa034501.07677526
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07530175
52Hippo signaling pathway_Homo sapiens_hsa043901.07004143
53Steroid hormone biosynthesis_Homo sapiens_hsa001401.05331276
54Peroxisome_Homo sapiens_hsa041461.05157734
55Sphingolipid metabolism_Homo sapiens_hsa006001.03762945
56Calcium signaling pathway_Homo sapiens_hsa040201.03450456
57Glucagon signaling pathway_Homo sapiens_hsa049221.03410412
58Axon guidance_Homo sapiens_hsa043601.02463165
59Regulation of autophagy_Homo sapiens_hsa041401.02170768
60GABAergic synapse_Homo sapiens_hsa047271.01466416
61Ether lipid metabolism_Homo sapiens_hsa005650.99464464
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97814595
63Renin secretion_Homo sapiens_hsa049240.96901604
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96708301
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95356742
66Serotonergic synapse_Homo sapiens_hsa047260.94830691
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90797288
68Cocaine addiction_Homo sapiens_hsa050300.90169191
69Notch signaling pathway_Homo sapiens_hsa043300.88657262
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88170849
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.84141247
72Ovarian steroidogenesis_Homo sapiens_hsa049130.83515670
73Mineral absorption_Homo sapiens_hsa049780.82667284
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80630464
75Melanogenesis_Homo sapiens_hsa049160.80353222
76Hematopoietic cell lineage_Homo sapiens_hsa046400.79265768
77ECM-receptor interaction_Homo sapiens_hsa045120.77881986
78Pyrimidine metabolism_Homo sapiens_hsa002400.76151546
79Adherens junction_Homo sapiens_hsa045200.75309472
80Fatty acid elongation_Homo sapiens_hsa000620.73523718
81Propanoate metabolism_Homo sapiens_hsa006400.73179125
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72846520
83Cardiac muscle contraction_Homo sapiens_hsa042600.72810255
84Linoleic acid metabolism_Homo sapiens_hsa005910.72695472
85Dorso-ventral axis formation_Homo sapiens_hsa043200.71586447
86cAMP signaling pathway_Homo sapiens_hsa040240.70647595
87Measles_Homo sapiens_hsa051620.70174209
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69602939
89Arachidonic acid metabolism_Homo sapiens_hsa005900.69592982
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69520078
91Nucleotide excision repair_Homo sapiens_hsa034200.69241396
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.66965362
93Estrogen signaling pathway_Homo sapiens_hsa049150.65607335
94Butanoate metabolism_Homo sapiens_hsa006500.65130842
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.64477944
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64027472
97N-Glycan biosynthesis_Homo sapiens_hsa005100.63806987
98Dopaminergic synapse_Homo sapiens_hsa047280.63552442
99Salivary secretion_Homo sapiens_hsa049700.62753237
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62686081
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62166255
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60163812
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59651822
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58311846
105Nitrogen metabolism_Homo sapiens_hsa009100.58098522
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58050124
107Cell cycle_Homo sapiens_hsa041100.56163657
108Gap junction_Homo sapiens_hsa045400.56000078
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55946741
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55368340
111Protein export_Homo sapiens_hsa030600.53306542
112PPAR signaling pathway_Homo sapiens_hsa033200.53263077
113Choline metabolism in cancer_Homo sapiens_hsa052310.53227086
114Fatty acid degradation_Homo sapiens_hsa000710.52837032
115Steroid biosynthesis_Homo sapiens_hsa001000.52680738
116Cholinergic synapse_Homo sapiens_hsa047250.52544084
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52162630
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52134513
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51954207
120Herpes simplex infection_Homo sapiens_hsa051680.50768025
121Alcoholism_Homo sapiens_hsa050340.50465615
122Gastric acid secretion_Homo sapiens_hsa049710.49864420
123Wnt signaling pathway_Homo sapiens_hsa043100.49826303
124Endometrial cancer_Homo sapiens_hsa052130.49450646
125TGF-beta signaling pathway_Homo sapiens_hsa043500.48453543
126Dilated cardiomyopathy_Homo sapiens_hsa054140.47937634
127Legionellosis_Homo sapiens_hsa051340.47513203
128Proteasome_Homo sapiens_hsa030500.47484178
129RNA degradation_Homo sapiens_hsa030180.47010885
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.46682783
131Bile secretion_Homo sapiens_hsa049760.46449941
132Glycerolipid metabolism_Homo sapiens_hsa005610.46385833
133Basal cell carcinoma_Homo sapiens_hsa052170.46340837
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46133281
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44249967
136mRNA surveillance pathway_Homo sapiens_hsa030150.44140996
137Oocyte meiosis_Homo sapiens_hsa041140.42872920
138Oxytocin signaling pathway_Homo sapiens_hsa049210.42599113
139Influenza A_Homo sapiens_hsa051640.42531157
140Fatty acid biosynthesis_Homo sapiens_hsa000610.42358660
141Tuberculosis_Homo sapiens_hsa051520.42333792
142Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41913179
143TNF signaling pathway_Homo sapiens_hsa046680.41102588
144Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40998274
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.40726905
146Proteoglycans in cancer_Homo sapiens_hsa052050.40590125
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.40435760
148African trypanosomiasis_Homo sapiens_hsa051430.38668780
149Prostate cancer_Homo sapiens_hsa052150.38221562
150Fructose and mannose metabolism_Homo sapiens_hsa000510.38040972
151Thyroid hormone synthesis_Homo sapiens_hsa049180.36434268
152Hedgehog signaling pathway_Homo sapiens_hsa043400.36204984
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.35944510
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35321050
155ErbB signaling pathway_Homo sapiens_hsa040120.35061695
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34377326
157Amoebiasis_Homo sapiens_hsa051460.34247540
158Alzheimers disease_Homo sapiens_hsa050100.32819366

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