NEK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.17094872
2protein localization to chromosome, centromeric region (GO:0071459)5.06289498
3mitotic metaphase plate congression (GO:0007080)5.04789042
4nuclear pore organization (GO:0006999)4.88119281
5nuclear pore complex assembly (GO:0051292)4.81749323
6DNA ligation (GO:0006266)4.54527662
7mitotic chromosome condensation (GO:0007076)4.47154475
8regulation of spindle organization (GO:0090224)4.46267072
9mitotic nuclear envelope disassembly (GO:0007077)4.46204840
10* mitotic sister chromatid segregation (GO:0000070)4.45006287
11DNA replication-dependent nucleosome organization (GO:0034723)4.40148208
12DNA replication-dependent nucleosome assembly (GO:0006335)4.40148208
13metaphase plate congression (GO:0051310)4.34623877
14DNA topological change (GO:0006265)4.33410237
15* regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.32086456
16piRNA metabolic process (GO:0034587)4.28631855
17nuclear envelope disassembly (GO:0051081)4.17686455
18membrane disassembly (GO:0030397)4.17686455
19positive regulation of chromosome segregation (GO:0051984)4.15601785
20* sister chromatid segregation (GO:0000819)4.11250944
21microtubule depolymerization (GO:0007019)4.05986693
22attachment of spindle microtubules to kinetochore (GO:0008608)4.05475047
23DNA replication initiation (GO:0006270)4.00423505
24DNA unwinding involved in DNA replication (GO:0006268)3.90385122
25establishment of chromosome localization (GO:0051303)3.90142531
26DNA replication checkpoint (GO:0000076)3.88735728
27kinetochore organization (GO:0051383)3.87786704
28mitotic sister chromatid cohesion (GO:0007064)3.83029198
29* regulation of chromosome segregation (GO:0051983)3.80978089
30purine nucleobase biosynthetic process (GO:0009113)3.79729023
31nucleobase biosynthetic process (GO:0046112)3.78637326
32protein localization to chromosome (GO:0034502)3.77320641
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76212444
34histone exchange (GO:0043486)3.76149319
35protein K6-linked ubiquitination (GO:0085020)3.75302270
36regulation of mitotic spindle organization (GO:0060236)3.74634458
37pore complex assembly (GO:0046931)3.74546209
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.72887087
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.72887087
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.72887087
41chromatin remodeling at centromere (GO:0031055)3.72803509
42DNA strand elongation involved in DNA replication (GO:0006271)3.72234139
43synaptonemal complex assembly (GO:0007130)3.71715068
44spindle checkpoint (GO:0031577)3.65624160
45CENP-A containing nucleosome assembly (GO:0034080)3.63491527
46ventricular cardiac muscle cell development (GO:0055015)3.61718948
47chromosome condensation (GO:0030261)3.61625632
48meiotic chromosome segregation (GO:0045132)3.59615735
49DNA replication-independent nucleosome assembly (GO:0006336)3.59310055
50DNA replication-independent nucleosome organization (GO:0034724)3.59310055
51negative regulation of chromosome segregation (GO:0051985)3.57127423
52ribosome assembly (GO:0042255)3.53640908
53DNA strand elongation (GO:0022616)3.53247861
54synaptonemal complex organization (GO:0070193)3.51745169
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50794029
56regulation of histone H3-K9 methylation (GO:0051570)3.50730852
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.48529798
58negative regulation of sister chromatid segregation (GO:0033046)3.48529798
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.48529798
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.48529798
61negative regulation of mitosis (GO:0045839)3.48340095
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.46618633
63spindle assembly checkpoint (GO:0071173)3.46463010
64monoubiquitinated protein deubiquitination (GO:0035520)3.45350399
65establishment of integrated proviral latency (GO:0075713)3.45144370
66male meiosis (GO:0007140)3.44988000
67kinetochore assembly (GO:0051382)3.44953393
68mitotic spindle checkpoint (GO:0071174)3.43752235
69cilium or flagellum-dependent cell motility (GO:0001539)3.42796644
70microtubule polymerization or depolymerization (GO:0031109)3.41339000
71mitotic spindle assembly checkpoint (GO:0007094)3.40135248
72regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.39487440
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.39244985
74nuclear envelope organization (GO:0006998)3.37107952
75regulation of DNA endoreduplication (GO:0032875)3.33693451
76synapsis (GO:0007129)3.33481141
77replication fork processing (GO:0031297)3.32323099
78resolution of meiotic recombination intermediates (GO:0000712)3.31892151
79regulation of mitotic sister chromatid segregation (GO:0033047)3.31876008
80regulation of sister chromatid segregation (GO:0033045)3.31876008
81regulation of mitotic sister chromatid separation (GO:0010965)3.31876008
82DNA packaging (GO:0006323)3.31485926
83* chromosome segregation (GO:0007059)3.30531089
84chromatin assembly or disassembly (GO:0006333)3.29975775
85regulation of centriole replication (GO:0046599)3.27852837
86telomere maintenance via semi-conservative replication (GO:0032201)3.24259081
87* mitotic cell cycle (GO:0000278)3.23855960
88regulation of sister chromatid cohesion (GO:0007063)3.22826419
89mitotic G2/M transition checkpoint (GO:0044818)3.22445069
90* regulation of centrosome cycle (GO:0046605)3.21694699
91translesion synthesis (GO:0019985)3.20396063
92centriole replication (GO:0007099)3.20197986
93heterochromatin organization (GO:0070828)3.20194437
94regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19138569
95meiotic nuclear division (GO:0007126)3.18899404
96histone-serine phosphorylation (GO:0035404)3.18743657
97regulation of centrosome duplication (GO:0010824)3.17523354
98folic acid-containing compound biosynthetic process (GO:0009396)3.16710739
99DNA duplex unwinding (GO:0032508)3.16184432
100DNA geometric change (GO:0032392)3.16177805
101gene silencing by RNA (GO:0031047)3.16159043
102binding of sperm to zona pellucida (GO:0007339)3.15388458
103ribosome biogenesis (GO:0042254)3.14532898
104negative regulation of cell division (GO:0051782)3.11941561
105formation of translation preinitiation complex (GO:0001731)3.11388199
106ATP-dependent chromatin remodeling (GO:0043044)3.10723839
107mitotic recombination (GO:0006312)3.09185957
108chromosome organization involved in meiosis (GO:0070192)3.08887966
109meiosis I (GO:0007127)3.08373030
110negative regulation of nuclear division (GO:0051784)3.07813357
111telomere maintenance via recombination (GO:0000722)3.06520549
112regulation of RNA export from nucleus (GO:0046831)3.05456448
113DNA conformation change (GO:0071103)3.04219666
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03964966
115regulation of mitotic spindle checkpoint (GO:1903504)3.03964966
116meiotic cell cycle process (GO:1903046)3.02913268
117sperm-egg recognition (GO:0035036)3.01976710
118* mitotic nuclear division (GO:0007067)3.00036974
119proteasome assembly (GO:0043248)2.99938099
120nucleotide-excision repair, DNA gap filling (GO:0006297)2.99931995
121DNA double-strand break processing (GO:0000729)2.99885797
122male meiosis I (GO:0007141)2.97522811
123negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.96476217
124regulation of spindle checkpoint (GO:0090231)2.96190065
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95308044
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.95308044
127regulation of exit from mitosis (GO:0007096)2.93054466
128mitotic cytokinesis (GO:0000281)2.92806226
129double-strand break repair via nonhomologous end joining (GO:0006303)2.92703631
130non-recombinational repair (GO:0000726)2.92703631
131positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91886232
132* chromosome organization (GO:0051276)2.90017844

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.04067618
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.09545479
3* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.65494938
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11081449
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.80852476
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.58127273
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81009031
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69503454
9* AR_21909140_ChIP-Seq_LNCAP_Human2.52626785
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51177971
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.37901101
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32772242
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.30652454
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22391248
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19533574
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.18568871
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.18440154
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.13490281
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10421061
20XRN2_22483619_ChIP-Seq_HELA_Human2.04975735
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02402972
22* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00879180
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.93318452
24GABP_17652178_ChIP-ChIP_JURKAT_Human1.92600877
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90228329
26VDR_23849224_ChIP-Seq_CD4+_Human1.87304317
27POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81455476
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80047198
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68803397
30FOXP3_21729870_ChIP-Seq_TREG_Human1.68107974
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66397315
32GABP_19822575_ChIP-Seq_HepG2_Human1.65298801
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60335005
34KDM5A_27292631_Chip-Seq_BREAST_Human1.59355506
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57058420
36DCP1A_22483619_ChIP-Seq_HELA_Human1.56282958
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55610134
38* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.55219616
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.53672475
40MYC_22102868_ChIP-Seq_BL_Human1.53358942
41HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.51823676
42* TTF2_22483619_ChIP-Seq_HELA_Human1.46836141
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.40792016
44* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39995362
45CIITA_25753668_ChIP-Seq_RAJI_Human1.38597594
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.37694147
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37586455
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.36309703
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34802825
50* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33042341
51TP63_19390658_ChIP-ChIP_HaCaT_Human1.32314159
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29476258
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27805848
54EWS_26573619_Chip-Seq_HEK293_Human1.27103866
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27080636
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25883443
57DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24365508
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.24134198
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23250401
60* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20796345
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.20002132
62ELK1_19687146_ChIP-ChIP_HELA_Human1.18248189
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17602825
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16549449
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13492539
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13009957
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11422470
68FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11373475
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.11075757
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10464033
71* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10338645
72* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09869864
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.09300565
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.07817872
75* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.04237010
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03985271
77* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02782323
78FUS_26573619_Chip-Seq_HEK293_Human1.01477011
79NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97877942
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97034610
81TFEB_21752829_ChIP-Seq_HELA_Human0.96596415
82CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96418188
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96306960
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95634701
85ZNF274_21170338_ChIP-Seq_K562_Hela0.95609620
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94802821
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.94649293
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94531983
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94531983
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94531983
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94000676
92RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93801034
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.91391792
94ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87660648
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87043550
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86169725
97ZNF263_19887448_ChIP-Seq_K562_Human0.86053298
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85266321
99ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84379188
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83972232
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83607219
102VDR_22108803_ChIP-Seq_LS180_Human0.83111372
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81905440
104IRF1_19129219_ChIP-ChIP_H3396_Human0.81024068
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78323168
106TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.75568604
107* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.75158731
108* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.74985301
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.74924827
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.74880130
111TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74822565
112NOTCH1_21737748_ChIP-Seq_TLL_Human0.74455060
113SOX2_18692474_ChIP-Seq_MESCs_Mouse0.74229047
114SRF_21415370_ChIP-Seq_HL-1_Mouse0.74068798
115MYC_18940864_ChIP-ChIP_HL60_Human0.73737603
116CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73102645
117* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.72988297
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.72229682
119NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71854230
120POU3F2_20337985_ChIP-ChIP_501MEL_Human0.62722697
121* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.60706685
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.56721181
123* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.55254355
124CHD1_26751641_Chip-Seq_LNCaP_Human0.55163938

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38286481
2MP0003111_abnormal_nucleus_morphology4.86891685
3MP0010094_abnormal_chromosome_stability4.73837115
4MP0008057_abnormal_DNA_replication4.14398948
5MP0004957_abnormal_blastocyst_morpholog4.09153731
6MP0003077_abnormal_cell_cycle4.03115483
7MP0008877_abnormal_DNA_methylation3.28134881
8MP0008058_abnormal_DNA_repair3.01129768
9MP0005410_abnormal_fertilization2.80190634
10MP0008007_abnormal_cellular_replicative2.69964819
11MP0001730_embryonic_growth_arrest2.60266836
12MP0010307_abnormal_tumor_latency2.51660071
13MP0003136_yellow_coat_color2.46134420
14MP0008932_abnormal_embryonic_tissue2.41657576
15MP0003123_paternal_imprinting2.31536417
16MP0000350_abnormal_cell_proliferation2.28146215
17MP0001929_abnormal_gametogenesis2.23385971
18MP0002210_abnormal_sex_determination2.11207410
19MP0003786_premature_aging2.06711709
20MP0010352_gastrointestinal_tract_polyps2.06437777
21MP0001672_abnormal_embryogenesis/_devel1.98978840
22MP0005380_embryogenesis_phenotype1.98978840
23MP0002938_white_spotting1.96461102
24MP0003718_maternal_effect1.94818858
25MP0001697_abnormal_embryo_size1.84710727
26MP0009697_abnormal_copulation1.83506947
27MP0001145_abnormal_male_reproductive1.81663746
28MP0000372_irregular_coat_pigmentation1.79525203
29MP0003984_embryonic_growth_retardation1.75969882
30MP0003698_abnormal_male_reproductive1.72984757
31MP0002088_abnormal_embryonic_growth/wei1.71167063
32MP0002085_abnormal_embryonic_tissue1.69335976
33MP0005076_abnormal_cell_differentiation1.68939600
34MP0002653_abnormal_ependyma_morphology1.67373809
35MP0002080_prenatal_lethality1.65905970
36MP0002084_abnormal_developmental_patter1.65280713
37MP0000653_abnormal_sex_gland1.58177736
38MP0002086_abnormal_extraembryonic_tissu1.54654745
39MP0002396_abnormal_hematopoietic_system1.50048090
40MP0004197_abnormal_fetal_growth/weight/1.44184171
41MP0000566_synostosis1.42530228
42MP0000313_abnormal_cell_death1.41862925
43MP0004808_abnormal_hematopoietic_stem1.41180472
44MP0004147_increased_porphyrin_level1.36454180
45MP0000490_abnormal_crypts_of1.33757715
46MP0003806_abnormal_nucleotide_metabolis1.32957381
47MP0002019_abnormal_tumor_incidence1.29241238
48MP0005171_absent_coat_pigmentation1.26759171
49MP0002234_abnormal_pharynx_morphology1.24874273
50MP0001545_abnormal_hematopoietic_system1.24346563
51MP0005397_hematopoietic_system_phenotyp1.24346563
52MP0001346_abnormal_lacrimal_gland1.23541863
53MP0002161_abnormal_fertility/fecundity1.21724027
54MP0001293_anophthalmia1.19154561
55MP0002160_abnormal_reproductive_system1.18988705
56MP0003121_genomic_imprinting1.17841304
57MP0003890_abnormal_embryonic-extraembry1.13834734
58MP0003567_abnormal_fetal_cardiomyocyte1.09914781
59MP0009278_abnormal_bone_marrow1.09271902
60MP0000537_abnormal_urethra_morphology1.05877578
61MP0003705_abnormal_hypodermis_morpholog1.05416545
62MP0006072_abnormal_retinal_apoptosis1.05049284
63MP0005408_hypopigmentation1.04222338
64MP0001529_abnormal_vocalization1.02665771
65MP0008789_abnormal_olfactory_epithelium1.02269748
66MP0000647_abnormal_sebaceous_gland1.00285756
67MP0006035_abnormal_mitochondrial_morpho1.00048536
68MP0003937_abnormal_limbs/digits/tail_de0.97277696
69MP0002095_abnormal_skin_pigmentation0.97091667
70MP0002233_abnormal_nose_morphology0.96635246
71MP0003315_abnormal_perineum_morphology0.95339504
72MP0009333_abnormal_splenocyte_physiolog0.94546871
73MP0004264_abnormal_extraembryonic_tissu0.93087382
74MP0005389_reproductive_system_phenotype0.91491034
75MP0010030_abnormal_orbit_morphology0.89430662
76MP0000631_abnormal_neuroendocrine_gland0.89186037
77MP0009672_abnormal_birth_weight0.88915031
78MP0000358_abnormal_cell_content/0.88094926
79MP0001119_abnormal_female_reproductive0.87949300
80MP0000427_abnormal_hair_cycle0.86370440
81MP0005621_abnormal_cell_physiology0.85473020
82MP0000703_abnormal_thymus_morphology0.84014093
83MP0003186_abnormal_redox_activity0.83393048
84MP0005384_cellular_phenotype0.83372041
85MP0003119_abnormal_digestive_system0.83282538
86MP0001849_ear_inflammation0.83113652
87MP0009703_decreased_birth_body0.80719107
88MP0003755_abnormal_palate_morphology0.80170264
89MP0005391_vision/eye_phenotype0.80132383
90MP0002092_abnormal_eye_morphology0.80088202
91MP0003938_abnormal_ear_development0.78363770
92MP0003943_abnormal_hepatobiliary_system0.78339895
93MP0000428_abnormal_craniofacial_morphol0.77905262
94MP0006036_abnormal_mitochondrial_physio0.76859743
95MP0003699_abnormal_female_reproductive0.76616831
96MP0005377_hearing/vestibular/ear_phenot0.76505565
97MP0003878_abnormal_ear_physiology0.76505565
98MP0001919_abnormal_reproductive_system0.76420949
99MP0001299_abnormal_eye_distance/0.73605096
100MP0009053_abnormal_anal_canal0.73347659
101MP0002163_abnormal_gland_morphology0.69431610
102MP0002722_abnormal_immune_system0.69264241
103MP0000733_abnormal_muscle_development0.68865175
104MP0001915_intracranial_hemorrhage0.68534210
105MP0005174_abnormal_tail_pigmentation0.68143774
106MP0002398_abnormal_bone_marrow0.68098098
107MP0003221_abnormal_cardiomyocyte_apopto0.67061038
108MP0000432_abnormal_head_morphology0.64755543
109MP0002009_preneoplasia0.64616032
110MP0000689_abnormal_spleen_morphology0.63871022
111MP0002111_abnormal_tail_morphology0.63634954
112MP0005253_abnormal_eye_physiology0.63384548
113MP0000049_abnormal_middle_ear0.61222888
114MP0005395_other_phenotype0.61059136
115MP0001324_abnormal_eye_pigmentation0.60994260
116MP0005023_abnormal_wound_healing0.60894267
117MP0005499_abnormal_olfactory_system0.60859337
118MP0005394_taste/olfaction_phenotype0.60859337
119MP0003115_abnormal_respiratory_system0.59997675
120MP0000015_abnormal_ear_pigmentation0.59974457
121MP0008995_early_reproductive_senescence0.58715203
122MP0003935_abnormal_craniofacial_develop0.56940907
123MP0001727_abnormal_embryo_implantation0.56049184
124MP0003566_abnormal_cell_adhesion0.55682384
125MP0003941_abnormal_skin_development0.54707183
126MP0002102_abnormal_ear_morphology0.54551954
127MP0003861_abnormal_nervous_system0.53891899
128MP0002877_abnormal_melanocyte_morpholog0.53464537
129MP0000858_altered_metastatic_potential0.52506274
130MP0001286_abnormal_eye_development0.52289181
131MP0002697_abnormal_eye_size0.52022496
132MP0000477_abnormal_intestine_morphology0.50530062
133MP0002925_abnormal_cardiovascular_devel0.50404829
134MP0008260_abnormal_autophagy0.50081146
135MP0003763_abnormal_thymus_physiology0.49978360
136MP0006292_abnormal_olfactory_placode0.49436351
137MP0000627_abnormal_mammary_gland0.48786017

Predicted human phenotypes

RankGene SetZ-score
1Impulsivity (HP:0100710)4.43782645
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.26344676
3Chromsome breakage (HP:0040012)3.90834545
4Birth length less than 3rd percentile (HP:0003561)3.90110938
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.90054794
6Selective tooth agenesis (HP:0001592)3.65361376
7Breast hypoplasia (HP:0003187)3.57434511
8Abnormality of chromosome stability (HP:0003220)3.38483410
9Ependymoma (HP:0002888)3.31972286
10Degeneration of anterior horn cells (HP:0002398)3.25078780
11Abnormality of the anterior horn cell (HP:0006802)3.25078780
12Meckel diverticulum (HP:0002245)3.23041745
13Patellar aplasia (HP:0006443)3.17330756
14Abnormality of the preputium (HP:0100587)3.15497706
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.13565325
16Carpal bone hypoplasia (HP:0001498)3.12477727
17Abnormality of the ileum (HP:0001549)3.05417675
18Aplasia/Hypoplasia of the patella (HP:0006498)2.99927960
19Dynein arm defect of respiratory motile cilia (HP:0012255)2.99827618
20Absent/shortened dynein arms (HP:0200106)2.99827618
21Hypoplasia of the capital femoral epiphysis (HP:0003090)2.93018215
22Cortical dysplasia (HP:0002539)2.88829594
23Medulloblastoma (HP:0002885)2.88803028
24Duodenal stenosis (HP:0100867)2.87403447
25Small intestinal stenosis (HP:0012848)2.87403447
26Sloping forehead (HP:0000340)2.76544465
27Septo-optic dysplasia (HP:0100842)2.75352043
28Abnormality of the labia minora (HP:0012880)2.71431480
29Supernumerary spleens (HP:0009799)2.71263877
30Ectopic kidney (HP:0000086)2.67322318
31Absent radius (HP:0003974)2.63583692
32Abnormal spermatogenesis (HP:0008669)2.62654436
33Chronic bronchitis (HP:0004469)2.62290410
34Prominent nose (HP:0000448)2.62040171
35Rhinitis (HP:0012384)2.60088393
36Abnormal respiratory motile cilium physiology (HP:0012261)2.55600926
37Myelodysplasia (HP:0002863)2.54151678
38Abnormal respiratory epithelium morphology (HP:0012253)2.52503178
39Abnormal respiratory motile cilium morphology (HP:0005938)2.52503178
40Increased nuchal translucency (HP:0010880)2.50582791
41Absent thumb (HP:0009777)2.47419405
42Rough bone trabeculation (HP:0100670)2.44965122
43Rhabdomyosarcoma (HP:0002859)2.44949948
44Absent forearm bone (HP:0003953)2.44639243
45Aplasia involving forearm bones (HP:0009822)2.44639243
46Triphalangeal thumb (HP:0001199)2.44477466
47Abnormality of the lower motor neuron (HP:0002366)2.41595509
48Absent septum pellucidum (HP:0001331)2.41331162
49Nasal polyposis (HP:0100582)2.35429256
5011 pairs of ribs (HP:0000878)2.35184987
51Abnormality of the astrocytes (HP:0100707)2.34551538
52Astrocytoma (HP:0009592)2.34551538
53Oral leukoplakia (HP:0002745)2.33819703
54Cerebellar dysplasia (HP:0007033)2.33793638
55Abnormality of the carotid arteries (HP:0005344)2.32491753
56Agnosia (HP:0010524)2.31546563
57Duplicated collecting system (HP:0000081)2.30188553
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28619962
59Cafe-au-lait spot (HP:0000957)2.28561076
60Abnormality of the duodenum (HP:0002246)2.28125609
61Neoplasm of the pancreas (HP:0002894)2.28029741
62Reticulocytopenia (HP:0001896)2.27049597
63Facial hemangioma (HP:0000329)2.26325115
64Squamous cell carcinoma (HP:0002860)2.23299437
65Colon cancer (HP:0003003)2.22783346
66Male infertility (HP:0003251)2.21292901
67Abnormality of the septum pellucidum (HP:0007375)2.21280208
68Premature ovarian failure (HP:0008209)2.21263942
69Aplasia/hypoplasia of the humerus (HP:0006507)2.20886449
70Bone marrow hypocellularity (HP:0005528)2.20310200
71Proximal placement of thumb (HP:0009623)2.19568875
72Glioma (HP:0009733)2.17327734
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.17305157
74Absent epiphyses (HP:0010577)2.17305157
75Volvulus (HP:0002580)2.15858104
76High pitched voice (HP:0001620)2.14226415
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13305672
78Abnormality of alanine metabolism (HP:0010916)2.13305672
79Hyperalaninemia (HP:0003348)2.13305672
80Deviation of the thumb (HP:0009603)2.12374427
81Infertility (HP:0000789)2.11222213
82Increased hepatocellular lipid droplets (HP:0006565)2.06135840
83Ureteral duplication (HP:0000073)2.04770101
84Basal cell carcinoma (HP:0002671)2.03757771
85Cerebral hypomyelination (HP:0006808)2.03434797
86Missing ribs (HP:0000921)2.02371857
87Abnormal lung lobation (HP:0002101)2.02094035
88Entropion (HP:0000621)2.01594700
89Hypoplasia of the pons (HP:0012110)2.00425085
90Abnormality of the pons (HP:0007361)2.00047647
91Abnormality of the renal collecting system (HP:0004742)1.99746975
92Tracheoesophageal fistula (HP:0002575)1.99315608
93Neoplasm of the colon (HP:0100273)1.98993482
94Short humerus (HP:0005792)1.98771813
95Secondary amenorrhea (HP:0000869)1.98685256
96Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97895060
97Nephroblastoma (Wilms tumor) (HP:0002667)1.97396983
98Atrophy/Degeneration involving motor neurons (HP:0007373)1.97097141
99Biliary tract neoplasm (HP:0100574)1.96578281
100Neoplasm of the oral cavity (HP:0100649)1.95682130
101Atresia of the external auditory canal (HP:0000413)1.94628584
102Short thumb (HP:0009778)1.93728924
103Acute necrotizing encephalopathy (HP:0006965)1.93187592
104Neoplasm of striated muscle (HP:0009728)1.93114410
105Acute encephalopathy (HP:0006846)1.91685325
106Abnormality of glycolysis (HP:0004366)1.90823171
107Horseshoe kidney (HP:0000085)1.89278118
108Amyotrophic lateral sclerosis (HP:0007354)1.88735196
109Broad distal phalanx of finger (HP:0009836)1.87792241
110Pelvic girdle muscle weakness (HP:0003749)1.87562965
111Heterotopia (HP:0002282)1.87099498
112Increased CSF lactate (HP:0002490)1.86705134
113Choanal atresia (HP:0000453)1.85334260
114Facial cleft (HP:0002006)1.84729440
115Sparse lateral eyebrow (HP:0005338)1.84504099
116Lipid accumulation in hepatocytes (HP:0006561)1.84275588
117Molar tooth sign on MRI (HP:0002419)1.83134629
118Abnormality of midbrain morphology (HP:0002418)1.83134629
119Clubbing of toes (HP:0100760)1.82556810
120Oligodactyly (HP:0012165)1.82244866
121Small hand (HP:0200055)1.82054739
122Breast carcinoma (HP:0003002)1.81758818
123Abnormal mitochondria in muscle tissue (HP:0008316)1.81502260
124Azoospermia (HP:0000027)1.81016171
125Embryonal renal neoplasm (HP:0011794)1.80180810
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.79775420
127Oligodactyly (hands) (HP:0001180)1.78698135
128Increased serum pyruvate (HP:0003542)1.77006005
129Preaxial hand polydactyly (HP:0001177)1.75437032
130Duplication of thumb phalanx (HP:0009942)1.73502973
131Abnormality of cells of the erythroid lineage (HP:0012130)1.73194163
132Dandy-Walker malformation (HP:0001305)1.72837198
133Hypoplastic pelvis (HP:0008839)1.71853627
134Pancreatic cysts (HP:0001737)1.71837236
135Embryonal neoplasm (HP:0002898)1.71585143
136Abnormality of the proximal phalanges of the hand (HP:0009834)1.68407119
137Abnormal number of erythroid precursors (HP:0012131)1.68366893
138Arteriovenous malformation (HP:0100026)1.67764451
139Abnormality of DNA repair (HP:0003254)1.66688218
140Abnormality of chromosome segregation (HP:0002916)1.65636795
141Overlapping toe (HP:0001845)1.63563143
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63062124
143Aplasia/Hypoplasia of the fovea (HP:0008060)1.62482586
144Hypoplasia of the fovea (HP:0007750)1.62482586
145Type I transferrin isoform profile (HP:0003642)1.62185700
146Increased serum lactate (HP:0002151)1.62115256
147Holoprosencephaly (HP:0001360)1.60942320
148Optic nerve hypoplasia (HP:0000609)1.60797139
149Mitochondrial inheritance (HP:0001427)1.59175620
150Pancreatic fibrosis (HP:0100732)1.58099318
151Abnormal number of incisors (HP:0011064)1.57884345
152True hermaphroditism (HP:0010459)1.56824319
153Astigmatism (HP:0000483)1.56319154
154Pendular nystagmus (HP:0012043)1.55816949
155Ovarian neoplasm (HP:0100615)1.55705375
156Concave nail (HP:0001598)1.55508873

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.18206400
2WEE14.26380879
3CDC74.12315510
4PBK3.29611607
5TTK3.11207010
6* NEK23.06472157
7PDK32.99502272
8PDK42.99502272
9CDK122.54255362
10PLK42.38775527
11PLK12.20801002
12EIF2AK12.20051662
13EEF2K2.11072539
14BRSK22.08248903
15NEK12.00221852
16SRPK11.94566920
17TSSK61.87123221
18CHEK21.83885421
19PDK21.82607323
20VRK21.81314263
21ACVR1B1.78051579
22AURKB1.76052804
23STK101.65991850
24EPHA21.63174397
25TRIM281.62396200
26DYRK31.60697991
27ATR1.59919705
28PLK31.55179076
29CDK41.53174543
30CDK71.49178576
31CHEK11.47075391
32BRSK11.46740292
33TESK11.44205333
34TESK21.42667540
35MAP3K81.38538783
36RPS6KB21.35616271
37PASK1.34988540
38MST41.33261302
39AURKA1.25447681
40RPS6KA41.23961759
41CCNB11.23233877
42STK41.20277078
43PNCK1.18090262
44LATS11.16637721
45MAP3K101.12835132
46LATS21.06755486
47NUAK11.05549362
48MKNK11.05404615
49TLK11.02909739
50STK38L1.02262770
51ATM1.02224273
52ZAK0.98430936
53MKNK20.96583038
54EIF2AK30.93861357
55VRK10.93564924
56PAK40.92642003
57ICK0.91163374
58CDK20.90254140
59MELK0.86458198
60AKT30.85000630
61* STK30.82922036
62NME20.79451192
63CDK60.78677854
64CLK10.77560637
65MST1R0.75644579
66PAK10.74726858
67PIM10.74596953
68ALK0.74380963
69MTOR0.74155018
70NME10.73389300
71WNK30.71091302
72CDK10.70278024
73BRD40.69305569
74PKN20.67721588
75BRAF0.67563284
76BMPR1B0.65837977
77PRKD30.65399652
78MET0.65242315
79TAF10.63941014
80WNK40.61220225
81TNIK0.59866175
82SCYL20.59533899
83STK160.55807450
84ERBB30.55315692
85ERBB40.53882722
86PRKCI0.51713344
87BCR0.50251725
88PLK20.46871683
89CSNK2A20.45874707
90MAP4K20.45544405
91STK390.44009617
92CSNK2A10.42563692
93TRIB30.40356250
94MARK30.38758358
95RPS6KA50.38726038
96MAPKAPK30.36418330
97CSNK1E0.35603632
98CDK30.34598755
99CDK180.34003310
100CSNK1D0.33772364
101EIF2AK20.33230100
102PRKDC0.33141622
103AKT20.32809327
104KSR10.32690440
105PAK20.31727571
106LRRK20.31657240
107SIK30.30757426
108CDK11A0.29962101
109MAPKAPK50.29252319
110CDK150.28991917
111TGFBR10.28947761
112MAPK140.25465609
113CDK80.25421582
114UHMK10.25286763
115STK380.24034989
116CDK140.21291656
117DYRK1B0.20893304
118MAPK110.20551204
119MAP4K10.20433157
120GSK3B0.19412323
121CDK90.19295916
122GRK60.18041206
123TAOK10.17239021
124MAPK10.17220769
125PKN10.17162812
126FLT30.16659909
127RAF10.15059747
128BCKDK0.14781649
129RPS6KA10.14236608
130AKT10.14210032
131FGFR10.13927524
132PRKAA10.13742094
133NEK60.13074156
134MINK10.10908607

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.28834041
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.81931609
3Mismatch repair_Homo sapiens_hsa034303.70892751
4RNA transport_Homo sapiens_hsa030133.56627567
5Cell cycle_Homo sapiens_hsa041103.39997864
6Vitamin B6 metabolism_Homo sapiens_hsa007503.07285484
7Spliceosome_Homo sapiens_hsa030403.04258503
8Homologous recombination_Homo sapiens_hsa034402.90968300
9Fanconi anemia pathway_Homo sapiens_hsa034602.79339135
10Base excision repair_Homo sapiens_hsa034102.76566350
11RNA polymerase_Homo sapiens_hsa030202.76106943
12Nucleotide excision repair_Homo sapiens_hsa034202.60955261
13Basal transcription factors_Homo sapiens_hsa030222.38332796
14One carbon pool by folate_Homo sapiens_hsa006702.33995123
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19382966
16Proteasome_Homo sapiens_hsa030502.12870349
17mRNA surveillance pathway_Homo sapiens_hsa030152.08213199
18Pyrimidine metabolism_Homo sapiens_hsa002402.07556632
19p53 signaling pathway_Homo sapiens_hsa041152.02813463
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88366126
21Non-homologous end-joining_Homo sapiens_hsa034501.85659345
22RNA degradation_Homo sapiens_hsa030181.83794654
23Oocyte meiosis_Homo sapiens_hsa041141.65191557
24Protein export_Homo sapiens_hsa030601.61736619
25Systemic lupus erythematosus_Homo sapiens_hsa053221.58142602
26Ribosome_Homo sapiens_hsa030101.56178152
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.51870126
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51416870
29Oxidative phosphorylation_Homo sapiens_hsa001901.43113052
30Pentose phosphate pathway_Homo sapiens_hsa000301.39949065
31Parkinsons disease_Homo sapiens_hsa050121.38549748
32Viral carcinogenesis_Homo sapiens_hsa052031.28721649
33Epstein-Barr virus infection_Homo sapiens_hsa051691.25738894
34Huntingtons disease_Homo sapiens_hsa050161.25083790
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22728009
36Purine metabolism_Homo sapiens_hsa002301.21852474
37Selenocompound metabolism_Homo sapiens_hsa004501.21651976
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18662584
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15069671
40Propanoate metabolism_Homo sapiens_hsa006401.14599932
41Antigen processing and presentation_Homo sapiens_hsa046121.12718774
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.05611589
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04799623
44Biosynthesis of amino acids_Homo sapiens_hsa012301.02256597
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99116425
46Herpes simplex infection_Homo sapiens_hsa051680.93961133
47Steroid biosynthesis_Homo sapiens_hsa001000.90309554
48HTLV-I infection_Homo sapiens_hsa051660.85517283
49MicroRNAs in cancer_Homo sapiens_hsa052060.84613825
50Small cell lung cancer_Homo sapiens_hsa052220.84426843
51Fatty acid elongation_Homo sapiens_hsa000620.83359373
52Folate biosynthesis_Homo sapiens_hsa007900.81980170
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74248878
54Alzheimers disease_Homo sapiens_hsa050100.72047217
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69677222
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68623303
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68608347
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.65447900
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63752268
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62861317
61mTOR signaling pathway_Homo sapiens_hsa041500.61870667
62Sulfur metabolism_Homo sapiens_hsa009200.61630352
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58626215
64Hippo signaling pathway_Homo sapiens_hsa043900.57875348
65Alcoholism_Homo sapiens_hsa050340.57329594
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54116923
67Carbon metabolism_Homo sapiens_hsa012000.53782720
68Metabolic pathways_Homo sapiens_hsa011000.52847133
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52691367
70Legionellosis_Homo sapiens_hsa051340.51623411
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50309298
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.50295476
73Nitrogen metabolism_Homo sapiens_hsa009100.49741200
74Colorectal cancer_Homo sapiens_hsa052100.48269764
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47596868
76Fructose and mannose metabolism_Homo sapiens_hsa000510.47443415
77Butanoate metabolism_Homo sapiens_hsa006500.47244713
78Apoptosis_Homo sapiens_hsa042100.46006930
79Thyroid cancer_Homo sapiens_hsa052160.45824198
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.45213171
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44688417
82Basal cell carcinoma_Homo sapiens_hsa052170.44308113
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.41930727
84Sulfur relay system_Homo sapiens_hsa041220.41069527
85TGF-beta signaling pathway_Homo sapiens_hsa043500.41053929
86Hedgehog signaling pathway_Homo sapiens_hsa043400.41037413
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.40173022
88Chronic myeloid leukemia_Homo sapiens_hsa052200.39280580
89Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39021167
90Hepatitis B_Homo sapiens_hsa051610.38867603
91Phototransduction_Homo sapiens_hsa047440.38704767
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38068775
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33840779
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33493808
95Bladder cancer_Homo sapiens_hsa052190.32835343
96HIF-1 signaling pathway_Homo sapiens_hsa040660.32760323
97Prostate cancer_Homo sapiens_hsa052150.32462176
98Glutathione metabolism_Homo sapiens_hsa004800.32002741
99Notch signaling pathway_Homo sapiens_hsa043300.31477144
100Dorso-ventral axis formation_Homo sapiens_hsa043200.31194072
101Adherens junction_Homo sapiens_hsa045200.31123858
102Influenza A_Homo sapiens_hsa051640.29272204
103FoxO signaling pathway_Homo sapiens_hsa040680.28542365
104Arginine and proline metabolism_Homo sapiens_hsa003300.27290188
105Measles_Homo sapiens_hsa051620.26657132
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26456543
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26073445
108Fatty acid metabolism_Homo sapiens_hsa012120.26056754
109Pathways in cancer_Homo sapiens_hsa052000.25514866
110Wnt signaling pathway_Homo sapiens_hsa043100.25077298
111Linoleic acid metabolism_Homo sapiens_hsa005910.24402438
112Non-small cell lung cancer_Homo sapiens_hsa052230.24220279
113Vitamin digestion and absorption_Homo sapiens_hsa049770.24077588
114Pyruvate metabolism_Homo sapiens_hsa006200.23835460
115Primary immunodeficiency_Homo sapiens_hsa053400.23759873
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23279501
117Lysine degradation_Homo sapiens_hsa003100.23258304
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22507729
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.21520811
120NF-kappa B signaling pathway_Homo sapiens_hsa040640.21437578
121Olfactory transduction_Homo sapiens_hsa047400.20941281
122Regulation of autophagy_Homo sapiens_hsa041400.20391299
123Renin-angiotensin system_Homo sapiens_hsa046140.19825046
124Peroxisome_Homo sapiens_hsa041460.19550578
125N-Glycan biosynthesis_Homo sapiens_hsa005100.19403800
126AMPK signaling pathway_Homo sapiens_hsa041520.19385274
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19168024
128Inositol phosphate metabolism_Homo sapiens_hsa005620.18983321
129Tight junction_Homo sapiens_hsa045300.18440450
130Shigellosis_Homo sapiens_hsa051310.17899807
131Pancreatic cancer_Homo sapiens_hsa052120.17745881
132Acute myeloid leukemia_Homo sapiens_hsa052210.17676837
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17319817
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16186369
135Cardiac muscle contraction_Homo sapiens_hsa042600.15882724
136Tryptophan metabolism_Homo sapiens_hsa003800.14088610
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13143486
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.12081001
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.11138501

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