ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	snRNA processing (GO:0016180)	7.73372281
2	snRNA metabolic process (GO:0016073)	7.11974059
3	protein K11-linked deubiquitination (GO:0035871)	6.58527604
4	rRNA catabolic process (GO:0016075)	5.62929698
5	mitotic metaphase plate congression (GO:0007080)	5.60801943
6	UDP-N-acetylglucosamine metabolic process (GO:0006047)	5.56989574
7	peptidyl-threonine dephosphorylation (GO:0035970)	5.51411513
8	mitotic sister chromatid segregation (GO:0000070)	5.38817316
9	mitochondrion degradation (GO:0000422)	5.32493589
10	histone H3-K4 trimethylation (GO:0080182)	5.27154260
11	sister chromatid segregation (GO:0000819)	5.22186903
12	mismatch repair (GO:0006298)	5.15921506
13	purine nucleobase biosynthetic process (GO:0009113)	5.08599229
14	regulation of MHC class II biosynthetic process (GO:0045346)	4.87206316
15	metaphase plate congression (GO:0051310)	4.75788004
16	positive regulation of cytokinesis (GO:0032467)	4.69221862
17	reciprocal meiotic recombination (GO:0007131)	4.68197844
18	reciprocal DNA recombination (GO:0035825)	4.68197844
19	IMP biosynthetic process (GO:0006188)	4.57961536
20	nucleobase biosynthetic process (GO:0046112)	4.57482199
21	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	4.51935591
22	acrosome assembly (GO:0001675)	4.48929686
23	DNA replication initiation (GO:0006270)	4.45419319
24	positive regulation of histone H3-K4 methylation (GO:0051571)	4.41052950
25	vesicle targeting (GO:0006903)	4.30649728
26	C-terminal protein lipidation (GO:0006501)	4.22678035
27	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	4.19858664
28	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	4.19858664
29	positive regulation of mitotic sister chromatid separation (GO:1901970)	4.19858664
30	rRNA methylation (GO:0031167)	4.15108256
31	folic acid-containing compound biosynthetic process (GO:0009396)	4.06294587
32	negative regulation of fatty acid biosynthetic process (GO:0045717)	3.99247324
33	ncRNA catabolic process (GO:0034661)	3.98232846
34	mitotic chromosome condensation (GO:0007076)	3.94184882
35	microtubule depolymerization (GO:0007019)	3.93373311
36	protein localization to kinetochore (GO:0034501)	3.86334789
37	kinetochore organization (GO:0051383)	3.85788774
38	DNA replication checkpoint (GO:0000076)	3.84760319
39	rRNA modification (GO:0000154)	3.78778771
40	spindle checkpoint (GO:0031577)	3.76050399
41	N-acetylneuraminate metabolic process (GO:0006054)	3.75087661
42	regulation of chromosome segregation (GO:0051983)	3.71863555
43	IMP metabolic process (GO:0046040)	3.71668436
44	CENP-A containing nucleosome assembly (GO:0034080)	3.70102760
45	chromosome segregation (GO:0007059)	3.69981996
46	positive regulation of triglyceride biosynthetic process (GO:0010867)	3.68889515
47	carnitine metabolic process (GO:0009437)	3.67760048
48	establishment of chromosome localization (GO:0051303)	3.66590481
49	kinetochore assembly (GO:0051382)	3.66524503
50	positive regulation of chromosome segregation (GO:0051984)	3.64079474
51	C-terminal protein amino acid modification (GO:0018410)	3.63909606
52	granulocyte differentiation (GO:0030851)	3.61743410
53	mitotic G2/M transition checkpoint (GO:0044818)	3.59000667
54	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.57960802
55	chromatin remodeling at centromere (GO:0031055)	3.50942946
56	DNA topological change (GO:0006265)	3.44273280
57	regulation of mitotic spindle organization (GO:0060236)	3.43063987
58	mitotic spindle checkpoint (GO:0071174)	3.40948584
59	peptidyl-lysine trimethylation (GO:0018023)	3.37329554
60	mitochondrial RNA metabolic process (GO:0000959)	3.37220436
61	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.31844262
62	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.31844262
63	negative regulation of chromosome segregation (GO:0051985)	3.29571542
64	regulation of spindle organization (GO:0090224)	3.29408371
65	regulation of histone H3-K4 methylation (GO:0051569)	3.27877274
66	regulation of sister chromatid segregation (GO:0033045)	3.27762233
67	regulation of mitotic sister chromatid separation (GO:0010965)	3.27762233
68	regulation of mitotic sister chromatid segregation (GO:0033047)	3.27762233
69	regulation of meiosis I (GO:0060631)	3.26861770
70	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.25763947
71	negative regulation of sister chromatid segregation (GO:0033046)	3.25763947
72	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.25763947
73	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.25763947
74	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.25763947
75	mitotic spindle assembly checkpoint (GO:0007094)	3.23098736
76	regulation of centrosome cycle (GO:0046605)	3.21994475
77	interleukin-6-mediated signaling pathway (GO:0070102)	3.20548632
78	positive regulation of mitochondrial fission (GO:0090141)	3.19861326
79	protein localization to chromosome, centromeric region (GO:0071459)	3.18292782
80	spindle assembly checkpoint (GO:0071173)	3.18050874
81	positive regulation of DNA-templated transcription, elongation (GO:0032786)	3.13762327
82	chromosome condensation (GO:0030261)	3.11761417
83	histone exchange (GO:0043486)	3.11327516
84	protein K6-linked ubiquitination (GO:0085020)	3.10267052
85	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	3.08583877
86	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	3.08583877
87	meiosis I (GO:0007127)	3.08508520
88	female gamete generation (GO:0007292)	3.07647653
89	interkinetic nuclear migration (GO:0022027)	3.06318760
90	base-excision repair, AP site formation (GO:0006285)	3.05053473
91	chromosome organization involved in meiosis (GO:0070192)	3.04932890
92	synaptonemal complex assembly (GO:0007130)	3.04455308
93	tetrahydrofolate metabolic process (GO:0046653)	3.02689733
94	mitotic G2 DNA damage checkpoint (GO:0007095)	2.99989367
95	regulation of cytokinesis (GO:0032465)	2.99332665
96	L-fucose catabolic process (GO:0042355)	2.98840014
97	fucose catabolic process (GO:0019317)	2.98840014
98	L-fucose metabolic process (GO:0042354)	2.98840014
99	DNA ligation (GO:0006266)	2.98424168
100	meiotic chromosome segregation (GO:0045132)	10.9412043

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	6.54107906
2	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	5.10546075
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.23630366
4	E2F7_22180533_ChIP-Seq_HELA_Human	4.12115793
5	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	3.85937030
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.23319487
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.06941608
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.63595378
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.41317833
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.34020556
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.31687737
12	AR_21909140_ChIP-Seq_LNCAP_Human	2.29994095
13	EWS_26573619_Chip-Seq_HEK293_Human	2.27483425
14	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.20816754
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.08238254
16	VDR_22108803_ChIP-Seq_LS180_Human	2.00984551
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.00299525
18	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96403580
19	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.93904522
20	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.89998150
21	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.88814148
22	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.87561869
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.83711511
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.81043757
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.80826712
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.78960774
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.77770902
28	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.74242481
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.70785605
30	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.69420234
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.67187123
32	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.66813312
33	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.60241568
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.58866898
35	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.54272491
36	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.53691691
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.53059649
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.52696685
39	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.50933683
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50530505
41	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.50086192
42	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.48959452
43	FUS_26573619_Chip-Seq_HEK293_Human	1.48901699
44	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.45097400
45	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.43658727
46	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.43511420
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.37657541
48	TTF2_22483619_ChIP-Seq_HELA_Human	1.35954883
49	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.32006443
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.30200320
51	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.29906410
52	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.27309742
53	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.26991102
54	TFEB_21752829_ChIP-Seq_HELA_Human	1.25422243
55	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.20889237
56	GBX2_23144817_ChIP-Seq_PC3_Human	1.19550394
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.18406212
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17269755
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.16804905
60	RBPJ_21746931_ChIP-Seq_IB4_Human	1.14622430
61	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.13242760
62	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.10259608
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10216000
64	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	1.07045866
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05738992
66	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.04657992
67	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.04394092
68	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.03182353
69	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02591340
70	CBP_20019798_ChIP-Seq_JUKART_Human	1.02591340
71	XRN2_22483619_ChIP-Seq_HELA_Human	1.01663767
72	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00330267
73	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.00080639
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99352433
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98794398
76	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98794398
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.97298704
78	ETV1_20927104_ChIP-Seq_GIST48_Human	0.96492032
79	TCF4_23295773_ChIP-Seq_U87_Human	0.96211659
80	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.95045664
81	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.94857176
82	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.93506677
83	IRF1_19129219_ChIP-ChIP_H3396_Human	0.93273189
84	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.92159720
85	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.91309320
86	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.90860303
87	TP53_22573176_ChIP-Seq_HFKS_Human	0.89206776
88	CBX2_22325352_ChIP-Seq_293T-Rex_Human	0.88776423
89	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88616217
90	PHF8_20622853_ChIP-Seq_HELA_Human	0.88149488
91	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.88094320
92	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.87998584
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.86968991
94	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86968991
95	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	0.86085051
96	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.85960499
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.85755375
98	AR_20517297_ChIP-Seq_VCAP_Human	0.85341141
99	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85260877
100	HNFA_21074721_ChIP-Seq_CACO-2_Human	0.84755660

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	4.31838937
2	MP0008058_abnormal_DNA_repair	3.57918463
3	MP0003111_abnormal_nucleus_morphology	3.46241115
4	MP0003693_abnormal_embryo_hatching	3.25782467
5	MP0004957_abnormal_blastocyst_morpholog	3.16487395
6	MP0005310_abnormal_salivary_gland	3.15432487
7	MP0003718_maternal_effect	3.13996228
8	MP0003077_abnormal_cell_cycle	2.98177555
9	MP0004484_altered_response_of	2.74463122
10	MP0005646_abnormal_pituitary_gland	2.67955414
11	MP0006072_abnormal_retinal_apoptosis	2.63324772
12	MP0008877_abnormal_DNA_methylation	2.51857580
13	MP0008057_abnormal_DNA_replication	2.50785393
14	MP0005085_abnormal_gallbladder_physiolo	2.46903398
15	MP0003136_yellow_coat_color	2.37569436
16	MP0008932_abnormal_embryonic_tissue	2.26053224
17	MP0009764_decreased_sensitivity_to	2.13950169
18	MP0003646_muscle_fatigue	2.00703401
19	MP0009697_abnormal_copulation	2.00601444
20	MP0001764_abnormal_homeostasis	1.99242139
21	MP0009780_abnormal_chondrocyte_physiolo	1.94815136
22	MP0003221_abnormal_cardiomyocyte_apopto	1.90856075
23	MP0003011_delayed_dark_adaptation	1.86105902
24	MP0004147_increased_porphyrin_level	1.81577064
25	MP0004215_abnormal_myocardial_fiber	1.77024433
26	MP0004233_abnormal_muscle_weight	1.73318668
27	MP0002210_abnormal_sex_determination	1.70494722
28	MP0001929_abnormal_gametogenesis	1.61884777
29	MP0005253_abnormal_eye_physiology	1.60779250
30	MP0003937_abnormal_limbs/digits/tail_de	1.54182021
31	MP0005410_abnormal_fertilization	1.52389241
32	MP0005551_abnormal_eye_electrophysiolog	1.46884093
33	MP0004782_abnormal_surfactant_physiolog	1.45363294
34	MP0003195_calcinosis	1.43138850
35	MP0002876_abnormal_thyroid_physiology	1.37602993
36	MP0003786_premature_aging	1.36271602
37	MP0006035_abnormal_mitochondrial_morpho	1.35722772
38	MP0005395_other_phenotype	1.33611099
39	MP0003698_abnormal_male_reproductive	1.31640903
40	MP0005360_urolithiasis	1.24406476
41	MP0000653_abnormal_sex_gland	1.23487467
42	MP0000631_abnormal_neuroendocrine_gland	1.21599664
43	MP0001145_abnormal_male_reproductive	1.21532162
44	MP0001119_abnormal_female_reproductive	1.21019003
45	MP0008872_abnormal_physiological_respon	1.20157847
46	MP0005332_abnormal_amino_acid	1.19699855
47	MP0006036_abnormal_mitochondrial_physio	1.18049125
48	MP0004084_abnormal_cardiac_muscle	1.15539120
49	MP0001697_abnormal_embryo_size	1.14471291
50	MP0008995_early_reproductive_senescence	1.11724358
51	MP0009643_abnormal_urine_homeostasis	1.10564868
52	MP0005380_embryogenesis_phenotype	1.10217601
53	MP0001672_abnormal_embryogenesis/_devel	1.10217601
54	MP0008775_abnormal_heart_ventricle	1.09374017
55	MP0002928_abnormal_bile_duct	1.08271666
56	MP0001286_abnormal_eye_development	1.05927030
57	MP0000372_irregular_coat_pigmentation	1.04728528
58	MP0002085_abnormal_embryonic_tissue	1.02539393
59	MP0002938_white_spotting	1.01033964
60	MP0005647_abnormal_sex_gland	0.99909058
61	MP0008875_abnormal_xenobiotic_pharmacok	0.98077725
62	MP0004133_heterotaxia	0.93748238
63	MP0001324_abnormal_eye_pigmentation	0.93068499
64	MP0002080_prenatal_lethality	0.92974533
65	MP0006292_abnormal_olfactory_placode	0.90285567
66	MP0008007_abnormal_cellular_replicative	0.90018363
67	MP0005167_abnormal_blood-brain_barrier	0.88057229
68	MP0005365_abnormal_bile_salt	0.87898431
69	MP0003699_abnormal_female_reproductive	0.86246837
70	MP0002084_abnormal_developmental_patter	0.86036535
71	MP0003787_abnormal_imprinting	0.85735681
72	MP0002127_abnormal_cardiovascular_syste	0.85709686
73	MP0002161_abnormal_fertility/fecundity	0.85404399
74	MP0003567_abnormal_fetal_cardiomyocyte	0.85322102
75	MP0003984_embryonic_growth_retardation	0.83648652
76	MP0002088_abnormal_embryonic_growth/wei	0.80561120
77	MP0001730_embryonic_growth_arrest	0.79117891
78	MP0003186_abnormal_redox_activity	0.77641864
79	MP0004742_abnormal_vestibular_system	0.76599844
80	MP0004085_abnormal_heartbeat	0.75413287
81	MP0009672_abnormal_birth_weight	0.75355410
82	MP0003941_abnormal_skin_development	0.75254014
83	MP0002234_abnormal_pharynx_morphology	0.74442361
84	MP0001293_anophthalmia	0.74127850
85	MP0005076_abnormal_cell_differentiation	0.73720105
86	MP0000427_abnormal_hair_cycle	0.72794982
87	MP0000383_abnormal_hair_follicle	0.72766449
88	MP0003115_abnormal_respiratory_system	0.72747675
89	MP0002111_abnormal_tail_morphology	0.71325130
90	MP0009703_decreased_birth_body	0.69421207
91	MP0005391_vision/eye_phenotype	0.67840917
92	MP0001177_atelectasis	0.67164242
93	MP0000358_abnormal_cell_content/	0.66852730
94	MP0002019_abnormal_tumor_incidence	0.66188091
95	MP0004197_abnormal_fetal_growth/weight/	0.65856999
96	MP0009745_abnormal_behavioral_response	0.64549819
97	MP0002269_muscular_atrophy	0.64360170
98	MP0004043_abnormal_pH_regulation	0.64318674
99	MP0000350_abnormal_cell_proliferation	0.63161322
100	MP0005220_abnormal_exocrine_pancreas	0.61727094

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic bronchitis (HP:0004469)	5.11178040
2	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.02990049
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.09530359
4	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.97888570
5	Flat occiput (HP:0005469)	3.86553469
6	Pigmentary retinal degeneration (HP:0001146)	3.84700577
7	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.83472856
8	Abnormality of alanine metabolism (HP:0010916)	3.83472856
9	Hyperalaninemia (HP:0003348)	3.83472856
10	Thyroid-stimulating hormone excess (HP:0002925)	3.68089060
11	True hermaphroditism (HP:0010459)	3.63750623
12	Abnormality of the ileum (HP:0001549)	3.62323753
13	Meckel diverticulum (HP:0002245)	3.60922390
14	Chromsome breakage (HP:0040012)	3.51044377
15	Choroideremia (HP:0001139)	3.49323715
16	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.48287741
17	Cerebellar dysplasia (HP:0007033)	3.34026105
18	Bile duct proliferation (HP:0001408)	3.33880852
19	Abnormal biliary tract physiology (HP:0012439)	3.33880852
20	Abnormal rod and cone electroretinograms (HP:0008323)	3.31822307
21	Biliary tract neoplasm (HP:0100574)	3.20456644
22	Sloping forehead (HP:0000340)	3.18238893
23	Abnormality of the preputium (HP:0100587)	3.15603921
24	Rimmed vacuoles (HP:0003805)	3.15363406
25	Small intestinal stenosis (HP:0012848)	3.14981410
26	Duodenal stenosis (HP:0100867)	3.14981410
27	Abnormality of chromosome stability (HP:0003220)	2.95058796
28	Birth length less than 3rd percentile (HP:0003561)	2.93151775
29	Pancreatic cysts (HP:0001737)	2.91198247
30	Pancreatic fibrosis (HP:0100732)	2.89017170
31	Nephroblastoma (Wilms tumor) (HP:0002667)	2.88168943
32	Attenuation of retinal blood vessels (HP:0007843)	2.86628630
33	Cortical dysplasia (HP:0002539)	2.83560287
34	Embryonal renal neoplasm (HP:0011794)	2.79407433
35	Abnormal lung lobation (HP:0002101)	2.74608245
36	Abnormality of the duodenum (HP:0002246)	2.71469056
37	Hypoplasia of the pons (HP:0012110)	2.71033927
38	Bony spicule pigmentary retinopathy (HP:0007737)	2.70801413
39	Ependymoma (HP:0002888)	2.70703537
40	Ovarian neoplasm (HP:0100615)	2.65409800
41	Decreased central vision (HP:0007663)	2.64425838
42	Abnormality of midbrain morphology (HP:0002418)	2.64030795
43	Molar tooth sign on MRI (HP:0002419)	2.64030795
44	Decreased circulating renin level (HP:0003351)	2.48250259
45	Abnormality of the pons (HP:0007361)	2.47522834
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.45013132
47	Horseshoe kidney (HP:0000085)	2.43140859
48	Gonadal dysgenesis (HP:0000133)	2.41391407
49	Severe Myopia (HP:0011003)	2.39079308
50	Abnormality of the carotid arteries (HP:0005344)	2.38338626
51	Clubbing of toes (HP:0100760)	2.34194226
52	Recurrent otitis media (HP:0000403)	2.32222888
53	Chronic hepatic failure (HP:0100626)	2.29714702
54	Rhinitis (HP:0012384)	2.28144381
55	Neoplasm of the colon (HP:0100273)	2.27717480
56	Type II lissencephaly (HP:0007260)	2.26793233
57	Limb-girdle muscle atrophy (HP:0003797)	2.10122654
58	Hypoplastic pelvis (HP:0008839)	2.09783655
59	Neoplasm of the rectum (HP:0100743)	2.03226874
60	Abnormality of the labia minora (HP:0012880)	2.01810572
61	Oligohydramnios (HP:0001562)	2.01269622
62	Dry hair (HP:0011359)	1.98176745
63	Astigmatism (HP:0000483)	1.97492486
64	Poor head control (HP:0002421)	1.95656225
65	Glioma (HP:0009733)	1.94335175
66	Retinitis pigmentosa (HP:0000510)	1.93900087
67	Squamous cell carcinoma (HP:0002860)	1.93586652
68	Myelodysplasia (HP:0002863)	1.93333081
69	Neoplasm of the small intestine (HP:0100833)	1.93122286
70	Abnormal biliary tract morphology (HP:0012440)	1.92824836
71	Degeneration of anterior horn cells (HP:0002398)	1.91543473
72	Abnormality of the anterior horn cell (HP:0006802)	1.91543473
73	Preaxial hand polydactyly (HP:0001177)	1.91024455
74	Lipid accumulation in hepatocytes (HP:0006561)	1.90816236
75	Occipital encephalocele (HP:0002085)	1.90467517
76	Triphalangeal thumb (HP:0001199)	1.87695178
77	Abnormality of serum amino acid levels (HP:0003112)	1.85795371
78	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.84472006
79	Ectopic kidney (HP:0000086)	1.83292956
80	Sclerocornea (HP:0000647)	1.81515426
81	Aplasia involving forearm bones (HP:0009822)	1.80438279
82	Absent forearm bone (HP:0003953)	1.80438279
83	Bronchitis (HP:0012387)	1.80302264
84	Intrahepatic cholestasis (HP:0001406)	1.79875031
85	Dandy-Walker malformation (HP:0001305)	1.79206228
86	Postaxial foot polydactyly (HP:0001830)	1.78709660
87	Hyperglycinuria (HP:0003108)	1.78011434
88	Absent radius (HP:0003974)	1.77565359
89	Hyperkalemia (HP:0002153)	1.76375031
90	Abnormality of incisor morphology (HP:0011063)	1.76291634
91	Neutropenia (HP:0001875)	1.73910073
92	Acanthocytosis (HP:0001927)	1.72327283
93	Hypocalcemia (HP:0002901)	1.69940474
94	Hypokalemic alkalosis (HP:0001949)	1.69303055
95	Pendular nystagmus (HP:0012043)	1.68588473
96	Anencephaly (HP:0002323)	1.68437483
97	Long toe (HP:0010511)	1.67826390
98	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.67297680
99	Increased nuchal translucency (HP:0010880)	1.67140864
100	Embryonal neoplasm (HP:0002898)	1.67129730

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BLK	7.08761128
2	BUB1	5.18895223
3	MAP3K9	4.16052844
4	TTK	3.39397170
5	ZAK	2.72072876
6	CAMK1D	2.70454469
7	NEK1	2.68098966
8	CAMKK2	2.60210103
9	WEE1	2.50159424
10	NEK2	2.48432076
11	FRK	2.34322572
12	SRPK1	2.29618691
13	PBK	2.25811136
14	BRSK2	2.24964006
15	PLK3	2.04501137
16	EIF2AK1	1.95336183
17	TSSK6	1.79368190
18	PLK4	1.79338433
19	PLK1	1.74249909
20	CAMK1G	1.73576835
21	MKNK1	1.47330856
22	DYRK3	1.35224897
23	RPS6KA4	1.28587981
24	MKNK2	1.27415873
25	CDC7	1.26595338
26	NUAK1	1.24251961
27	BRSK1	1.21552810
28	PINK1	1.19481345
29	TRIM28	1.16311924
30	EIF2AK3	1.15971904
31	STK3	1.13175646
32	MELK	1.11968659
33	PDK1	1.10827707
34	EPHA4	1.07559191
35	PDPK1	1.07336356
36	AURKB	1.07060239
37	ATR	1.06746772
38	CHEK2	1.06530881
39	MARK3	1.05126558
40	MAPKAPK5	1.04529446
41	CAMK4	1.03758502
42	MAP3K8	0.93956812
43	ADRBK2	0.92774828
44	MST4	0.90647840
45	WNK3	0.89852742
46	VRK1	0.88523039
47	BMPR1B	0.75862662
48	BMX	0.73300465
49	CDK9	0.72677723
50	PKN1	0.71461740
51	FLT3	0.71063100
52	DYRK2	0.70984980
53	PRKCI	0.68435969
54	STK10	0.67561970
55	CSNK1E	0.64499771
56	BRAF	0.60172619
57	CHEK1	0.57361144
58	ACVR1B	0.57223009
59	STK38L	0.56432541
60	BRD4	0.55345964
61	EIF2AK2	0.54578794
62	CDK1	0.53787305
63	MAPKAPK3	0.53525145
64	CCNB1	0.51774616
65	LATS1	0.49915749
66	KSR1	0.49870790
67	ALK	0.48375984
68	PLK2	0.45753997
69	PKN2	0.45157048
70	ERBB2	0.44800056
71	ERBB3	0.43589468
72	HIPK2	0.43508325
73	CAMKK1	0.43334141
74	TNIK	0.42424838
75	PRKCE	0.41229503
76	CSNK2A2	0.39181672
77	AURKA	0.38796129
78	TNK2	0.37838162
79	WNK4	0.37512698
80	ATM	0.36415918
81	TGFBR1	0.35893799
82	GRK1	0.34330955
83	VRK2	0.30873940
84	MAP4K2	0.30619294
85	CDK7	0.30499668
86	PASK	0.30284220
87	TLK1	0.27770949
88	CSNK2A1	0.25307510
89	RPS6KA5	0.25083454
90	PTK2B	0.24807184
91	CDK2	0.24472465
92	PRKCG	0.21753139
93	FGFR1	0.20707307
94	STK4	0.20623635
95	BCR	0.20564898
96	ROCK1	0.17917761
97	MAP2K7	0.17580274
98	ADRBK1	0.17388682
99	CLK1	0.14248726
100	MAP3K4	0.12461093

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Propanoate metabolism_Homo sapiens_hsa00640	3.96298395
2	Mismatch repair_Homo sapiens_hsa03430	3.78441953
3	One carbon pool by folate_Homo sapiens_hsa00670	3.58822633
4	Regulation of autophagy_Homo sapiens_hsa04140	3.39661043
5	Cysteine and methionine metabolism_Homo sapiens_hsa00270	3.31079986
6	Pyruvate metabolism_Homo sapiens_hsa00620	2.84278840
7	Cell cycle_Homo sapiens_hsa04110	2.74469573
8	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.73365340
9	Homologous recombination_Homo sapiens_hsa03440	2.53068069
10	Selenocompound metabolism_Homo sapiens_hsa00450	2.50285681
11	Caffeine metabolism_Homo sapiens_hsa00232	2.44849548
12	Non-homologous end-joining_Homo sapiens_hsa03450	2.30195141
13	DNA replication_Homo sapiens_hsa03030	2.26718043
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.23368713
15	Linoleic acid metabolism_Homo sapiens_hsa00591	2.15039271
16	Steroid biosynthesis_Homo sapiens_hsa00100	2.06158124
17	Basal transcription factors_Homo sapiens_hsa03022	1.96529917
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94645889
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.81498779
20	Fatty acid metabolism_Homo sapiens_hsa01212	1.79670181
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.79486157
22	Base excision repair_Homo sapiens_hsa03410	1.79414174
23	RNA transport_Homo sapiens_hsa03013	1.69773554
24	RNA degradation_Homo sapiens_hsa03018	1.69231045
25	Fatty acid degradation_Homo sapiens_hsa00071	1.64617897
26	Proteasome_Homo sapiens_hsa03050	1.63274388
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.44742463
28	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.42366266
29	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.39391256
30	RNA polymerase_Homo sapiens_hsa03020	1.36110712
31	Lysine degradation_Homo sapiens_hsa00310	1.28453178
32	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.23059857
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.22583899
34	Oocyte meiosis_Homo sapiens_hsa04114	1.18430218
35	Sulfur metabolism_Homo sapiens_hsa00920	1.18264230
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.17386369
37	Ether lipid metabolism_Homo sapiens_hsa00565	1.16791524
38	Butanoate metabolism_Homo sapiens_hsa00650	1.15728830
39	p53 signaling pathway_Homo sapiens_hsa04115	1.08992413
40	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.07881602
41	Sulfur relay system_Homo sapiens_hsa04122	1.07303046
42	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06834317
43	Tryptophan metabolism_Homo sapiens_hsa00380	1.02035391
44	Spliceosome_Homo sapiens_hsa03040	1.01425643
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99843767
46	Phototransduction_Homo sapiens_hsa04744	0.97153365
47	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.91040341
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88564977
49	mRNA surveillance pathway_Homo sapiens_hsa03015	0.82119464
50	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.81481542
51	Purine metabolism_Homo sapiens_hsa00230	0.78577202
52	FoxO signaling pathway_Homo sapiens_hsa04068	0.78479786
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76997621
54	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.73894754
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.70875956
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.70394284
57	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.70044232
58	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63842928
59	PPAR signaling pathway_Homo sapiens_hsa03320	0.61003913
60	Arginine and proline metabolism_Homo sapiens_hsa00330	0.59448970
61	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.58672975
62	Metabolic pathways_Homo sapiens_hsa01100	0.57745070
63	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.52363391
64	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.51927401
65	Glucagon signaling pathway_Homo sapiens_hsa04922	0.51703242
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51608835
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51320176
68	Glutathione metabolism_Homo sapiens_hsa00480	0.50833933
69	Carbon metabolism_Homo sapiens_hsa01200	0.49789172
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.48763442
71	Protein export_Homo sapiens_hsa03060	0.48061047
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.43850493
73	Fatty acid elongation_Homo sapiens_hsa00062	0.43491245
74	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42089130
75	Arginine biosynthesis_Homo sapiens_hsa00220	0.40590823
76	Huntingtons disease_Homo sapiens_hsa05016	0.36283011
77	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34355215
78	Olfactory transduction_Homo sapiens_hsa04740	0.33393882
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31311901
80	Retinol metabolism_Homo sapiens_hsa00830	0.30974293
81	Morphine addiction_Homo sapiens_hsa05032	0.23968912
82	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.23217818
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.17541956
84	Parkinsons disease_Homo sapiens_hsa05012	0.16449922
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.15263708
86	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.12432944
87	Taste transduction_Homo sapiens_hsa04742	0.09409215
88	AMPK signaling pathway_Homo sapiens_hsa04152	0.08550607
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.08402673
90	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.08353194
91	Serotonergic synapse_Homo sapiens_hsa04726	0.08020163
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.07067706
93	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.07050375
94	Peroxisome_Homo sapiens_hsa04146	0.06918283
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.06702037
96	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.06583711
97	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.05707536
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.04881649
99	Oxidative phosphorylation_Homo sapiens_hsa00190	0.03162298
100	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.02978787

NEK2P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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