NEK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.30957454
2axonemal dynein complex assembly (GO:0070286)7.61640246
3sperm motility (GO:0030317)7.10445860
4nuclear pore complex assembly (GO:0051292)6.90069254
5epithelial cilium movement (GO:0003351)6.53693751
6motile cilium assembly (GO:0044458)6.47344108
7fusion of sperm to egg plasma membrane (GO:0007342)6.42834244
8sperm-egg recognition (GO:0035036)6.21255160
9nuclear pore organization (GO:0006999)6.13734083
10cilium movement (GO:0003341)6.05665014
11binding of sperm to zona pellucida (GO:0007339)5.96693337
12acrosome assembly (GO:0001675)5.86212173
13piRNA metabolic process (GO:0034587)5.79934259
14spermatid development (GO:0007286)5.72461352
15acrosome reaction (GO:0007340)5.66653422
16cell-cell recognition (GO:0009988)5.65171293
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.30709105
18regulation of centriole replication (GO:0046599)5.11375432
19pore complex assembly (GO:0046931)4.94889285
20male meiosis (GO:0007140)4.94618142
21plasma membrane fusion (GO:0045026)4.92266260
22multicellular organism reproduction (GO:0032504)4.90084615
23synaptonemal complex organization (GO:0070193)4.86381794
24synaptonemal complex assembly (GO:0007130)4.74962828
25cell wall macromolecule catabolic process (GO:0016998)4.63030175
26cell wall macromolecule metabolic process (GO:0044036)4.63030175
27macroautophagy (GO:0016236)4.26458752
28regulation of DNA endoreduplication (GO:0032875)4.19505685
29ventricular system development (GO:0021591)4.18792432
30regulation of RNA export from nucleus (GO:0046831)4.16484098
31chaperone-mediated protein complex assembly (GO:0051131)4.08332430
32reproduction (GO:0000003)4.00767659
33microtubule depolymerization (GO:0007019)3.99943165
34regulation of cilium movement (GO:0003352)3.95664028
35chromosome organization involved in meiosis (GO:0070192)3.94514142
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.74026134
37DNA methylation involved in gamete generation (GO:0043046)3.69859236
38single fertilization (GO:0007338)3.68681924
39negative regulation of DNA repair (GO:0045738)3.66769540
40synapsis (GO:0007129)3.61586423
41cytoplasmic mRNA processing body assembly (GO:0033962)3.59409548
42spermatogenesis (GO:0007283)3.59229916
43male gamete generation (GO:0048232)3.58593221
44gene silencing by RNA (GO:0031047)3.55632258
45mitotic sister chromatid cohesion (GO:0007064)3.54078634
46protein complex localization (GO:0031503)3.52240714
47monoubiquitinated protein deubiquitination (GO:0035520)3.50122203
48regulation of protein polyubiquitination (GO:1902914)3.49368677
49germ cell development (GO:0007281)3.48136548
50regulation of inclusion body assembly (GO:0090083)3.42630505
51negative regulation of inclusion body assembly (GO:0090084)3.42495000
52meiotic chromosome segregation (GO:0045132)3.40839226
53centriole assembly (GO:0098534)3.39904161
54spindle assembly involved in mitosis (GO:0090307)3.38128794
55regulation of centrosome cycle (GO:0046605)3.37170445
56folic acid-containing compound biosynthetic process (GO:0009396)3.36940413
57regulation of nucleobase-containing compound transport (GO:0032239)3.35394555
58seminiferous tubule development (GO:0072520)3.35243814
59gamete generation (GO:0007276)3.26527933
60male meiosis I (GO:0007141)3.24589077
61cellular protein complex localization (GO:0034629)3.23281559
62fertilization (GO:0009566)3.22043194
63intra-S DNA damage checkpoint (GO:0031573)3.21688873
64centriole replication (GO:0007099)3.19359581
65non-recombinational repair (GO:0000726)3.15577545
66double-strand break repair via nonhomologous end joining (GO:0006303)3.15577545
67regulation of centrosome duplication (GO:0010824)3.15423964
68aspartate family amino acid catabolic process (GO:0009068)3.14701620
69meiotic nuclear division (GO:0007126)3.13627378
70DNA synthesis involved in DNA repair (GO:0000731)3.12485111
71protein localization to kinetochore (GO:0034501)3.12368131
72NLS-bearing protein import into nucleus (GO:0006607)3.10790793
73pre-miRNA processing (GO:0031054)3.10161355
74cellular process involved in reproduction in multicellular organism (GO:0022412)3.07699706
75microtubule severing (GO:0051013)3.04082630
76sperm capacitation (GO:0048240)3.00962686
77histone H2A acetylation (GO:0043968)3.00098052
78protein K11-linked deubiquitination (GO:0035871)2.96917582
79somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96003156
80somatic hypermutation of immunoglobulin genes (GO:0016446)2.96003156
81neural tube formation (GO:0001841)2.94768109
82protein localization to cilium (GO:0061512)2.93715762
83positive regulation of mitochondrial fission (GO:0090141)2.93443134
84lactate metabolic process (GO:0006089)2.93364253
85regulation of histone H3-K9 methylation (GO:0051570)2.93184628
86protein localization to chromosome, centromeric region (GO:0071459)2.89928041
87DNA unwinding involved in DNA replication (GO:0006268)2.89163184
88cell recognition (GO:0008037)2.88297565
89microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.85337569
90nucleus organization (GO:0006997)2.83609066
91cilium assembly (GO:0042384)2.82335541
92DNA duplex unwinding (GO:0032508)2.80691689
93sister chromatid segregation (GO:0000819)2.80518225
94establishment of nucleus localization (GO:0040023)2.78990917
95organic cation transport (GO:0015695)2.78882195
96regulation of hippo signaling (GO:0035330)2.77677850
97intraciliary transport (GO:0042073)2.77057902
98DNA geometric change (GO:0032392)2.76849688
99microtubule anchoring (GO:0034453)2.76231586
100sister chromatid cohesion (GO:0007062)2.74503800
101microtubule polymerization or depolymerization (GO:0031109)2.73019065
102DNA replication initiation (GO:0006270)2.72262052
103DNA strand elongation involved in DNA replication (GO:0006271)2.72027528
104L-serine metabolic process (GO:0006563)2.71346529
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.70925338
106DNA replication-dependent nucleosome organization (GO:0034723)2.69746842
107DNA replication-dependent nucleosome assembly (GO:0006335)2.69746842
108mitotic nuclear envelope disassembly (GO:0007077)2.68799960
109mitochondrial fusion (GO:0008053)2.68089299
110DNA double-strand break processing (GO:0000729)2.67384047
111DNA strand elongation (GO:0022616)2.67119057
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.66610348
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66610348
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66610348
115gene silencing (GO:0016458)2.65389294
116phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.63918410
117protein K6-linked ubiquitination (GO:0085020)2.63687462
118pyrimidine nucleobase catabolic process (GO:0006208)2.61737371
119interkinetic nuclear migration (GO:0022027)2.59845257
120protein localization to chromosome (GO:0034502)2.59838836
121microtubule-based movement (GO:0007018)2.59439275
122calcium ion-dependent exocytosis (GO:0017156)2.58092547
123regulation of transforming growth factor beta2 production (GO:0032909)2.56633595
124mitotic sister chromatid segregation (GO:0000070)2.56527672
125response to pheromone (GO:0019236)2.55323459
126protein polyglutamylation (GO:0018095)2.54637225
127myelin assembly (GO:0032288)2.52954667
128positive regulation of chromosome segregation (GO:0051984)2.52519789
129cilium organization (GO:0044782)2.51963661
130lipid translocation (GO:0034204)2.51659292
131phospholipid translocation (GO:0045332)2.51659292
132genitalia morphogenesis (GO:0035112)2.51468568
133metaphase plate congression (GO:0051310)2.51192243
134RNA localization (GO:0006403)2.51099258
135membrane disassembly (GO:0030397)2.50879436
136nuclear envelope disassembly (GO:0051081)2.50879436
137reciprocal meiotic recombination (GO:0007131)2.50538698
138reciprocal DNA recombination (GO:0035825)2.50538698
139multicellular organismal reproductive process (GO:0048609)2.49983351
140axoneme assembly (GO:0035082)2.49975161
141glycerol ether metabolic process (GO:0006662)2.49889563
142mitotic metaphase plate congression (GO:0007080)2.49775533
143regulation of spindle checkpoint (GO:0090231)2.49009899
144negative regulation of DNA-dependent DNA replication (GO:2000104)2.48875666
145negative regulation of organelle assembly (GO:1902116)2.48427216
146meiotic cell cycle (GO:0051321)2.48406269
147translesion synthesis (GO:0019985)2.47587047
148positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.47015203
149mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.47015203
150meiosis I (GO:0007127)2.46964422
151protein K48-linked deubiquitination (GO:0071108)2.46541613
152negative regulation of histone methylation (GO:0031061)2.46475461
153glucocorticoid receptor signaling pathway (GO:0042921)2.46469840
154biotin metabolic process (GO:0006768)2.45974525
155snRNA processing (GO:0016180)2.45844885
156mitochondrial fission (GO:0000266)2.45782329
157centrosome duplication (GO:0051298)2.45336768
158chromatin remodeling at centromere (GO:0031055)2.44945195
159histone-serine phosphorylation (GO:0035404)2.44214768
160histone exchange (GO:0043486)2.41938870
161mitotic spindle organization (GO:0007052)2.41628326
162telomere maintenance via semi-conservative replication (GO:0032201)2.41351603
163CENP-A containing nucleosome assembly (GO:0034080)2.41033877
164snRNA metabolic process (GO:0016073)2.40972773
165rRNA catabolic process (GO:0016075)2.40756652
166microtubule organizing center organization (GO:0031023)2.40315258
167telomere maintenance via recombination (GO:0000722)2.40135255
168nucleus localization (GO:0051647)2.39521996
169mitotic recombination (GO:0006312)2.39090046
170ATP-dependent chromatin remodeling (GO:0043044)2.35648938
171protein localization to microtubule cytoskeleton (GO:0072698)2.33358728
172negative regulation of DNA recombination (GO:0045910)2.33079324
173regulation of gene silencing by RNA (GO:0060966)2.32076178
174regulation of gene silencing by miRNA (GO:0060964)2.32076178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.04857430
2EZH2_22144423_ChIP-Seq_EOC_Human4.16337122
3E2F7_22180533_ChIP-Seq_HELA_Human3.99996695
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.67439127
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.31987522
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.16474097
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.08279012
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.07062527
9AR_21909140_ChIP-Seq_LNCAP_Human2.69485913
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.53646303
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.42695673
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.35128311
13CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.26426439
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22729522
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09540585
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08506323
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.97021369
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90867540
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.86665536
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71699951
21PIAS1_25552417_ChIP-Seq_VCAP_Human1.69950775
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.68632872
23FUS_26573619_Chip-Seq_HEK293_Human1.68276612
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.65017065
25PKCTHETA_26484144_Chip-Seq_BREAST_Human1.62787194
26VDR_22108803_ChIP-Seq_LS180_Human1.62339798
27SMAD4_21799915_ChIP-Seq_A2780_Human1.61483805
28GBX2_23144817_ChIP-Seq_PC3_Human1.59066977
29ER_23166858_ChIP-Seq_MCF-7_Human1.58309338
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58300881
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56533280
32P300_19829295_ChIP-Seq_ESCs_Human1.55336105
33TAF15_26573619_Chip-Seq_HEK293_Human1.53824696
34AR_21572438_ChIP-Seq_LNCaP_Human1.46883079
35ZNF274_21170338_ChIP-Seq_K562_Hela1.44183027
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44061388
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43509227
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42938305
39IRF1_19129219_ChIP-ChIP_H3396_Human1.42395523
40SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34202967
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32060627
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.31412780
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30413204
44IGF1R_20145208_ChIP-Seq_DFB_Human1.30187574
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28102100
46TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.27969625
47ELK4_26923725_Chip-Seq_MESODERM_Mouse1.24628420
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22251927
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.20628586
50SOX9_26525672_Chip-Seq_HEART_Mouse1.19559505
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17664175
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17446650
53FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16299442
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15060879
55AR_25329375_ChIP-Seq_VCAP_Human1.14847305
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14684029
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13700217
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13700217
59FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13067012
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12992586
61NANOG_18555785_Chip-Seq_ESCs_Mouse1.12875244
62* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12099475
63RUNX2_22187159_ChIP-Seq_PCA_Human1.10877450
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10845475
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10788838
66MYC_18940864_ChIP-ChIP_HL60_Human1.07704586
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.07677204
68ELK1_19687146_ChIP-ChIP_HELA_Human1.07635931
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05810728
70* CBP_20019798_ChIP-Seq_JUKART_Human1.05643482
71* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05643482
72NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.05584719
73* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05297665
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04682379
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04252774
76FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03821132
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02647051
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02591689
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01721018
80POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00923709
81SOX2_22085726_ChIP-Seq_NPCs_Mouse1.00498045
82* REST_21632747_ChIP-Seq_MESCs_Mouse1.00407304
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00221983
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00030342
85EZH2_27294783_Chip-Seq_NPCs_Mouse0.99791875
86CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99601167
87GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.99417242
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99302004
89E2F1_18555785_Chip-Seq_ESCs_Mouse0.98766475
90NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98730362
91FLI1_21867929_ChIP-Seq_TH2_Mouse0.98699485
92EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98633746
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.97823327
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96566999
95ARNT_22903824_ChIP-Seq_MCF-7_Human0.96137398
96TCF4_22108803_ChIP-Seq_LS180_Human0.95468300
97MYC_18555785_ChIP-Seq_MESCs_Mouse0.95201034
98AHR_22903824_ChIP-Seq_MCF-7_Human0.94973389
99MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94435384
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93691634
101NFE2_27457419_Chip-Seq_LIVER_Mouse0.93428934
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93332671
103HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93324336
104TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92078048
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92033744
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92006735
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91855280
108WT1_19549856_ChIP-ChIP_CCG9911_Human0.91302975
109TCF4_23295773_ChIP-Seq_U87_Human0.91273440
110CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90893690
111RNF2_27304074_Chip-Seq_NSC_Mouse0.90832655
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90477156
113CDX2_22108803_ChIP-Seq_LS180_Human0.89442668
114KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.89164501
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89163296
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89008926
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88974866
118FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88825682
119TBX3_20139965_ChIP-Seq_ESCs_Mouse0.88603708
120PADI4_21655091_ChIP-ChIP_MCF-7_Human0.88491886
121TBX3_20139965_ChIP-Seq_MESCs_Mouse0.88229150
122EWS_26573619_Chip-Seq_HEK293_Human0.87939898
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84322757
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.83738889
125* STAT3_23295773_ChIP-Seq_U87_Human0.83547711
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.82309666
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82239518
128* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.82165603
129* TAL1_26923725_Chip-Seq_HPCs_Mouse0.81759689
130NANOG_21062744_ChIP-ChIP_HESCs_Human0.81517207
131LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.81315121
132NANOG_16518401_ChIP-PET_MESCs_Mouse0.80357630
133SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80271012
134SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79779134
135SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.78986065
136E2F1_21310950_ChIP-Seq_MCF-7_Human0.77595734
137* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.77266849
138TBL1_22424771_ChIP-Seq_293T_Human0.76686371
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75568505
140* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.75365404
141GABP_19822575_ChIP-Seq_HepG2_Human0.74749142
142SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73644909
143KDM5A_27292631_Chip-Seq_BREAST_Human0.71632615
144AUTS2_25519132_ChIP-Seq_293T-REX_Human0.71517441
145XRN2_22483619_ChIP-Seq_HELA_Human0.70187167
146MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.69664395
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68662816
148* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.68420807
149NFYB_21822215_ChIP-Seq_K562_Human0.68170594
150E2F1_17053090_ChIP-ChIP_MCF-7_Human0.67466516

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.37835238
2MP0008877_abnormal_DNA_methylation4.08690397
3MP0003698_abnormal_male_reproductive3.46794459
4MP0002653_abnormal_ependyma_morphology3.31131953
5MP0001929_abnormal_gametogenesis3.17710672
6MP0002139_abnormal_hepatobiliary_system3.11067492
7MP0002009_preneoplasia2.96585740
8MP0008057_abnormal_DNA_replication2.88625836
9MP0010094_abnormal_chromosome_stability2.57783324
10MP0003693_abnormal_embryo_hatching2.44625458
11MP0003787_abnormal_imprinting2.38725863
12MP0002210_abnormal_sex_determination2.28275782
13MP0001145_abnormal_male_reproductive2.06524587
14MP0002822_catalepsy2.03178875
15MP0003121_genomic_imprinting1.98302308
16MP0010030_abnormal_orbit_morphology1.98275566
17MP0002161_abnormal_fertility/fecundity1.95566355
18MP0000537_abnormal_urethra_morphology1.91608484
19MP0000383_abnormal_hair_follicle1.90496912
20MP0004133_heterotaxia1.89329909
21MP0003136_yellow_coat_color1.88645644
22MP0000653_abnormal_sex_gland1.83088942
23MP0004233_abnormal_muscle_weight1.82863060
24MP0005365_abnormal_bile_salt1.82639665
25MP0005085_abnormal_gallbladder_physiolo1.79507052
26MP0000569_abnormal_digit_pigmentation1.73691982
27MP0008058_abnormal_DNA_repair1.71102817
28MP0003937_abnormal_limbs/digits/tail_de1.67877895
29MP0009697_abnormal_copulation1.66389210
30MP0008007_abnormal_cellular_replicative1.62411917
31MP0003011_delayed_dark_adaptation1.62224268
32MP0001293_anophthalmia1.61757612
33MP0010678_abnormal_skin_adnexa1.61486719
34MP0003806_abnormal_nucleotide_metabolis1.58722822
35MP0000427_abnormal_hair_cycle1.56235443
36MP0003111_abnormal_nucleus_morphology1.55224162
37MP0002102_abnormal_ear_morphology1.52456598
38MP0003890_abnormal_embryonic-extraembry1.48798539
39MP0004134_abnormal_chest_morphology1.48503926
40MP0003718_maternal_effect1.48231121
41MP0005076_abnormal_cell_differentiation1.39830024
42MP0003115_abnormal_respiratory_system1.39012410
43MP0003123_paternal_imprinting1.38916319
44MP0003077_abnormal_cell_cycle1.31871109
45MP0004957_abnormal_blastocyst_morpholog1.31295416
46MP0005253_abnormal_eye_physiology1.27892920
47MP0004885_abnormal_endolymph1.26343731
48MP0005551_abnormal_eye_electrophysiolog1.25314324
49MP0002090_abnormal_vision1.24928729
50MP0005360_urolithiasis1.24073965
51MP0002234_abnormal_pharynx_morphology1.23917745
52MP0001730_embryonic_growth_arrest1.23915411
53MP0002909_abnormal_adrenal_gland1.23699393
54MP0002282_abnormal_trachea_morphology1.22075210
55MP0000647_abnormal_sebaceous_gland1.21906643
56MP0000778_abnormal_nervous_system1.21901495
57MP0005623_abnormal_meninges_morphology1.21159135
58MP0010352_gastrointestinal_tract_polyps1.20365735
59MP0001286_abnormal_eye_development1.19703287
60MP0003122_maternal_imprinting1.18564354
61MP0002736_abnormal_nociception_after1.17328987
62MP0002697_abnormal_eye_size1.15601749
63MP0005646_abnormal_pituitary_gland1.15265454
64MP0008932_abnormal_embryonic_tissue1.13985264
65MP0001529_abnormal_vocalization1.12372003
66MP0001324_abnormal_eye_pigmentation1.11523904
67MP0000631_abnormal_neuroendocrine_gland1.11270177
68MP0002084_abnormal_developmental_patter1.10374638
69MP0003950_abnormal_plasma_membrane1.09861653
70MP0003119_abnormal_digestive_system1.08437316
71MP0002938_white_spotting1.08290495
72MP0002160_abnormal_reproductive_system1.06390064
73MP0005391_vision/eye_phenotype1.05806052
74MP0002233_abnormal_nose_morphology1.03327784
75MP0010329_abnormal_lipoprotein_level1.02016845
76MP0009672_abnormal_birth_weight1.01848606
77MP0002638_abnormal_pupillary_reflex1.00828518
78MP0005187_abnormal_penis_morphology0.99927347
79MP0010307_abnormal_tumor_latency0.97841800
80MP0003786_premature_aging0.97822911
81MP0004859_abnormal_synaptic_plasticity0.97199099
82MP0002092_abnormal_eye_morphology0.96150206
83MP0002396_abnormal_hematopoietic_system0.95798744
84MP0002152_abnormal_brain_morphology0.95678964
85MP0001764_abnormal_homeostasis0.94860458
86MP0006276_abnormal_autonomic_nervous0.92942845
87MP0009703_decreased_birth_body0.92561723
88MP0002735_abnormal_chemical_nociception0.91670531
89MP0000955_abnormal_spinal_cord0.91323505
90MP0005394_taste/olfaction_phenotype0.90745993
91MP0005499_abnormal_olfactory_system0.90745993
92MP0010386_abnormal_urinary_bladder0.90486890
93MP0001984_abnormal_olfaction0.90140354
94MP0006292_abnormal_olfactory_placode0.89709707
95MP0002138_abnormal_hepatobiliary_system0.89261969
96MP0003861_abnormal_nervous_system0.89199981
97MP0001661_extended_life_span0.88986542
98MP0009780_abnormal_chondrocyte_physiolo0.87196073
99MP0001299_abnormal_eye_distance/0.86768723
100MP0005248_abnormal_Harderian_gland0.86517937
101MP0003868_abnormal_feces_composition0.86347028
102MP0003942_abnormal_urinary_system0.86147581
103MP0004185_abnormal_adipocyte_glucose0.85920887
104MP0001672_abnormal_embryogenesis/_devel0.85611327
105MP0005380_embryogenesis_phenotype0.85611327
106MP0003632_abnormal_nervous_system0.85539972
107MP0003329_amyloid_beta_deposits0.84647358
108MP0003705_abnormal_hypodermis_morpholog0.84404527
109MP0005408_hypopigmentation0.83641097
110MP0002086_abnormal_extraembryonic_tissu0.82370795
111MP0009046_muscle_twitch0.82085233
112MP0005647_abnormal_sex_gland0.81590206
113MP0000358_abnormal_cell_content/0.81423375
114MP0001697_abnormal_embryo_size0.81323725
115MP0008789_abnormal_olfactory_epithelium0.78818391
116MP0005220_abnormal_exocrine_pancreas0.78435340
117MP0000462_abnormal_digestive_system0.78224084
118MP0003567_abnormal_fetal_cardiomyocyte0.77555460
119MP0003935_abnormal_craniofacial_develop0.76865699
120MP0000350_abnormal_cell_proliferation0.76626756
121MP0003984_embryonic_growth_retardation0.75962499
122MP0002085_abnormal_embryonic_tissue0.75879003
123MP0002063_abnormal_learning/memory/cond0.74532950
124MP0001486_abnormal_startle_reflex0.74139829
125MP0004270_analgesia0.73713439
126MP0002127_abnormal_cardiovascular_syste0.73510340
127MP0005332_abnormal_amino_acid0.72157625
128MP0003252_abnormal_bile_duct0.71613591
129MP0002088_abnormal_embryonic_growth/wei0.71559172
130MP0005389_reproductive_system_phenotype0.70823154
131MP0000428_abnormal_craniofacial_morphol0.70484581
132MP0005174_abnormal_tail_pigmentation0.69936631
133MP0005395_other_phenotype0.69904752
134MP0002080_prenatal_lethality0.69826147
135MP0001270_distended_abdomen0.68757190
136MP0002928_abnormal_bile_duct0.66763326
137MP0005386_behavior/neurological_phenoty0.66636837
138MP0004924_abnormal_behavior0.66636837
139MP0004197_abnormal_fetal_growth/weight/0.66596785
140MP0008875_abnormal_xenobiotic_pharmacok0.65380074
141MP0005377_hearing/vestibular/ear_phenot0.65180194
142MP0003878_abnormal_ear_physiology0.65180194
143MP0002064_seizures0.63718756
144MP0003635_abnormal_synaptic_transmissio0.63430914
145MP0005670_abnormal_white_adipose0.63278226
146MP0000534_abnormal_ureter_morphology0.63139437
147MP0003943_abnormal_hepatobiliary_system0.63021880

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.90013093
2Absent/shortened dynein arms (HP:0200106)8.29221382
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.29221382
4Abnormal respiratory motile cilium physiology (HP:0012261)7.07900079
5Rhinitis (HP:0012384)6.04028104
6Abnormal respiratory epithelium morphology (HP:0012253)5.87445660
7Abnormal respiratory motile cilium morphology (HP:0005938)5.87445660
8Abnormal ciliary motility (HP:0012262)5.66487371
9Chronic bronchitis (HP:0004469)5.24299757
10Volvulus (HP:0002580)3.48171852
11Infertility (HP:0000789)3.42057281
12Nasal polyposis (HP:0100582)3.36458498
13High anterior hairline (HP:0009890)3.25766594
14Abnormality of the lower motor neuron (HP:0002366)3.16288162
15Chronic hepatic failure (HP:0100626)3.15968858
16Chromsome breakage (HP:0040012)3.02470523
17Fibular hypoplasia (HP:0003038)2.99345578
18Bronchiectasis (HP:0002110)2.99189821
19Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95354902
20Nephronophthisis (HP:0000090)2.94026763
21Aplasia/Hypoplasia of the sternum (HP:0006714)2.86439839
22Back pain (HP:0003418)2.72743768
23Bell-shaped thorax (HP:0001591)2.71577083
24Renovascular hypertension (HP:0100817)2.56353583
25Bronchitis (HP:0012387)2.53767783
26Absent frontal sinuses (HP:0002688)2.47448713
27Abnormality of the nasal mucosa (HP:0000433)2.47057007
28Hypochromic microcytic anemia (HP:0004840)2.38492269
29Abnormality of chromosome stability (HP:0003220)2.37996558
30Medulloblastoma (HP:0002885)2.37306692
31Birth length less than 3rd percentile (HP:0003561)2.35175513
32Tubulointerstitial abnormality (HP:0001969)2.34480324
33Hyperacusis (HP:0010780)2.31605771
34Hepatoblastoma (HP:0002884)2.31497369
35Abnormality of the renal medulla (HP:0100957)2.30873807
36Tubulointerstitial fibrosis (HP:0005576)2.30114464
37Abnormal auditory evoked potentials (HP:0006958)2.28489327
38Drooling (HP:0002307)2.27887447
39Overriding aorta (HP:0002623)2.27612985
40Occipital encephalocele (HP:0002085)2.23938420
41Elfin facies (HP:0004428)2.23854872
42Neoplasm of the adrenal cortex (HP:0100641)2.22322248
43True hermaphroditism (HP:0010459)2.20965717
44Pancreatic cysts (HP:0001737)2.20577567
45Fibroma (HP:0010614)2.18273845
46Hyperventilation (HP:0002883)2.18198985
47Nephroblastoma (Wilms tumor) (HP:0002667)2.16946410
48Abnormality of the astrocytes (HP:0100707)2.15486007
49Astrocytoma (HP:0009592)2.15486007
50Cortical dysplasia (HP:0002539)2.15144978
5111 pairs of ribs (HP:0000878)2.13112563
52Thyroid carcinoma (HP:0002890)2.12025805
53Abnormal spermatogenesis (HP:0008669)2.10606341
54Gonadotropin excess (HP:0000837)2.09314492
55Tubulointerstitial nephritis (HP:0001970)2.08675575
56Heterotopia (HP:0002282)2.08417395
57Hypoplastic labia majora (HP:0000059)2.07525038
58Epidermoid cyst (HP:0200040)2.07506750
59Progressive inability to walk (HP:0002505)2.07505581
60Blue irides (HP:0000635)2.07045414
61Male infertility (HP:0003251)2.06303830
62Fibrous tissue neoplasm (HP:0012316)2.05972925
63Ectopic kidney (HP:0000086)2.05942440
64Papillary thyroid carcinoma (HP:0002895)2.04182052
65Oligodactyly (hands) (HP:0001180)2.04177503
66Embryonal renal neoplasm (HP:0011794)2.03133972
67Selective tooth agenesis (HP:0001592)2.01623119
68Pancreatic fibrosis (HP:0100732)2.00771852
69Thyroid-stimulating hormone excess (HP:0002925)1.99077877
70Medial flaring of the eyebrow (HP:0010747)1.98262915
71Excessive salivation (HP:0003781)1.98086799
72Meckel diverticulum (HP:0002245)1.95130913
73Cholecystitis (HP:0001082)1.94994518
74Abnormal gallbladder physiology (HP:0012438)1.94994518
75Sloping forehead (HP:0000340)1.94509441
76Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93747360
77Hypoplasia of the brainstem (HP:0002365)1.93747360
78Neoplasm of the oral cavity (HP:0100649)1.93549552
79Cerebellar dysplasia (HP:0007033)1.93414899
80Abnormality of alanine metabolism (HP:0010916)1.93343417
81Hyperalaninemia (HP:0003348)1.93343417
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93343417
83Molar tooth sign on MRI (HP:0002419)1.91586965
84Abnormality of midbrain morphology (HP:0002418)1.91586965
85Biliary tract neoplasm (HP:0100574)1.90578521
86Partial agenesis of the corpus callosum (HP:0001338)1.89628279
87Recurrent otitis media (HP:0000403)1.89174888
88Subacute progressive viral hepatitis (HP:0006572)1.88510813
89Abnormality of the carotid arteries (HP:0005344)1.88191615
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.87203282
91Colon cancer (HP:0003003)1.87181975
92Abnormality of the ileum (HP:0001549)1.86914738
93Increased nuchal translucency (HP:0010880)1.86447578
94Abnormality of the labia majora (HP:0012881)1.85309713
95Preaxial hand polydactyly (HP:0001177)1.82814253
96Renal duplication (HP:0000075)1.81307373
97Fair hair (HP:0002286)1.80485766
98Pheochromocytoma (HP:0002666)1.80070332
99Intrahepatic cholestasis (HP:0001406)1.78990628
100Insomnia (HP:0100785)1.78919117
101Aplasia/Hypoplasia of the fibula (HP:0006492)1.78871604
102Abnormality of the renal cortex (HP:0011035)1.78622198
103Bony spicule pigmentary retinopathy (HP:0007737)1.76506087
104Recurrent sinusitis (HP:0011108)1.76225799
105Missing ribs (HP:0000921)1.75008871
106Gastrointestinal carcinoma (HP:0002672)1.74914264
107Malignant gastrointestinal tract tumors (HP:0006749)1.74914264
108Capillary hemangiomas (HP:0005306)1.74662874
109Abnormal hair whorl (HP:0010721)1.74278745
110Leiomyosarcoma (HP:0100243)1.74190407
111Uterine leiomyosarcoma (HP:0002891)1.74190407
112Transitional cell carcinoma of the bladder (HP:0006740)1.73713733
113Protruding tongue (HP:0010808)1.73610422
114Supernumerary spleens (HP:0009799)1.73039242
115Labial hypoplasia (HP:0000066)1.73026592
116Glioma (HP:0009733)1.71830522
117Abnormality of the metopic suture (HP:0005556)1.71781847
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.71716642
119Hypoplastic female external genitalia (HP:0012815)1.70261989
120Lissencephaly (HP:0001339)1.70214614
121Deep philtrum (HP:0002002)1.69805468
122Abnormal lung lobation (HP:0002101)1.69753464
123Postaxial foot polydactyly (HP:0001830)1.67758114
124Congenital primary aphakia (HP:0007707)1.67418351
125Inability to walk (HP:0002540)1.66716423
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62513689
127Oculomotor apraxia (HP:0000657)1.62448138
128Urinary urgency (HP:0000012)1.62321592
129Gait imbalance (HP:0002141)1.62199521
130Absent radius (HP:0003974)1.62126286
131Wide intermamillary distance (HP:0006610)1.61869220
132Scrotal hypoplasia (HP:0000046)1.61277390
133Truncal obesity (HP:0001956)1.61260436
134Amyotrophic lateral sclerosis (HP:0007354)1.61190964
135Progressive sensorineural hearing impairment (HP:0000408)1.61174460
136Abnormality of the diencephalon (HP:0010662)1.60545751
137Posterior subcapsular cataract (HP:0007787)1.60309232
138Hypobetalipoproteinemia (HP:0003563)1.59331610
139Termporal pattern (HP:0011008)1.58801449
140Insidious onset (HP:0003587)1.58801449
141Vaginal atresia (HP:0000148)1.58755986
142Aplasia involving forearm bones (HP:0009822)1.58223249
143Absent forearm bone (HP:0003953)1.58223249
144Genital tract atresia (HP:0001827)1.58088037
145Neoplasm of the small intestine (HP:0100833)1.58010698
146Facial cleft (HP:0002006)1.56882151
147Megalencephaly (HP:0001355)1.56684721
148Abnormality of monocarboxylic acid metabolism (HP:0010996)1.55193471
149Cubitus valgus (HP:0002967)1.55087584
150Urethral obstruction (HP:0000796)1.52245398
151Poor coordination (HP:0002370)1.51735467
152Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.51116336
153Obsessive-compulsive behavior (HP:0000722)1.51075460
154Midline defect of the nose (HP:0004122)1.47978041
155Curly hair (HP:0002212)1.47147478
156Embryonal neoplasm (HP:0002898)1.46991793
157Flat cornea (HP:0007720)1.46700106
158Abnormality of the labia minora (HP:0012880)1.43607580
159Short ribs (HP:0000773)1.43458638
160Nephrogenic diabetes insipidus (HP:0009806)1.43441955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.92865958
2PDK44.87123068
3PDK34.87123068
4PNCK4.34089953
5PRKD33.42850172
6PDK22.63076929
7CDC72.49110128
8TESK12.43323744
9ZAK2.38774280
10WEE12.18570676
11VRK12.10616710
12STK392.07877618
13EEF2K1.88222848
14CASK1.86188165
15PLK31.76225779
16SRPK11.72374349
17MAP4K21.71720122
18STK31.71005681
19MST41.56726527
20MAP3K131.56669594
21MKNK21.54886225
22PBK1.53377472
23WNK41.53239749
24TTK1.53044553
25NEK21.52046864
26YES11.46699491
27MAP3K41.42935359
28CAMK1G1.42895287
29AKT31.36047272
30PASK1.35373198
31NTRK21.34562287
32EIF2AK11.34105015
33BMPR1B1.34082890
34MAP3K101.25138410
35MAPK151.24409935
36MKNK11.22751362
37PINK11.22213505
38ACVR1B1.17816948
39LATS11.14871006
40ATR1.13421618
41ALK1.11209507
42MET1.10996204
43MARK11.06625669
44SGK21.06177531
45WNK11.05563569
46LMTK21.04492726
47CAMKK21.03632293
48BCKDK1.03192703
49CSNK1A1L1.01552798
50PTK2B1.00963789
51MTOR0.98999853
52BUB10.98526850
53TRIM280.97705009
54CSNK1G30.94555308
55BRSK10.93075954
56ATM0.90645272
57CHEK10.88759032
58PTK60.88637966
59MAP2K40.87097686
60MAPK130.82797453
61TSSK60.82335394
62CDK70.80782092
63BMX0.78306298
64EPHA30.78061311
65CCNB10.74776170
66PKN20.74197255
67CSNK1G20.73315191
68NTRK30.73164364
69NLK0.72939257
70MINK10.72120823
71SGK2230.70570250
72SGK4940.70570250
73LATS20.69725003
74EPHA20.69470136
75STK240.68730424
76FRK0.67473242
77ERBB30.67314349
78RPS6KA40.66912807
79EPHB10.64757234
80FGR0.64646034
81TNIK0.63793639
82TGFBR10.63032507
83SGK30.62515202
84PLK20.61800629
85MELK0.61782736
86STK40.61327577
87CDK30.60971803
88PLK10.60406880
89TAF10.60280372
90PDGFRB0.60142461
91WNK30.60056453
92AURKB0.59810976
93TLK10.59519375
94NEK60.59454243
95BCR0.58996295
96CHEK20.58398361
97CDK20.57929012
98EIF2AK30.57859947
99BRSK20.57673085
100BRD40.57557682
101FER0.55351093
102MAP3K90.55229287
103DYRK30.52236871
104CDK40.51729381
105NEK90.51690454
106PRKCH0.50104315
107ERBB40.49586342
108MAP3K120.48843045
109CSNK1E0.46855793
110RPS6KA50.46674650
111PRKAA10.46560686
112STK38L0.46486407
113AURKA0.46369913
114STK380.46157901
115RPS6KB10.45628324
116CDK10.44965102
117TAOK30.44214984
118CDK180.43673299
119OXSR10.43005969
120NUAK10.42851666
121CDK140.42378193
122NEK10.42326733
123GRK60.41990975
124CDK120.40169164
125CDK60.39581803
126CDK150.39563245
127CSNK1G10.38865014
128LRRK20.38619043
129MAPKAPK50.38020336
130SCYL20.37927776
131CAMK1D0.37556667
132RPS6KB20.37034812
133DAPK10.35096200
134STK100.34944100
135KSR10.34612172
136PDK10.34433778
137MATK0.33511519
138MAP2K70.33195963
139GSK3B0.33164222
140KIT0.32706435
141PAK40.31986489
142CDK11A0.31684781
143PRKDC0.31302715
144CSNK1D0.31222855
145MAPK140.30610177
146PLK40.29926417

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.14669608
2Pyruvate metabolism_Homo sapiens_hsa006202.70967405
3Propanoate metabolism_Homo sapiens_hsa006402.59591639
4Dorso-ventral axis formation_Homo sapiens_hsa043202.36212168
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.35749312
6Selenocompound metabolism_Homo sapiens_hsa004502.34584216
7Nitrogen metabolism_Homo sapiens_hsa009102.29764567
8Cysteine and methionine metabolism_Homo sapiens_hsa002702.26104728
9One carbon pool by folate_Homo sapiens_hsa006702.22675692
10Vitamin B6 metabolism_Homo sapiens_hsa007502.21590968
11Biosynthesis of amino acids_Homo sapiens_hsa012302.15100273
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91637390
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85729311
14Basal transcription factors_Homo sapiens_hsa030221.82541199
15RNA transport_Homo sapiens_hsa030131.79637753
16DNA replication_Homo sapiens_hsa030301.74877807
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74049220
18Fatty acid metabolism_Homo sapiens_hsa012121.72225313
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71732756
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70581722
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.69447788
22Homologous recombination_Homo sapiens_hsa034401.67821479
23Steroid biosynthesis_Homo sapiens_hsa001001.63413413
24Fatty acid biosynthesis_Homo sapiens_hsa000611.60291550
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.59061139
26Carbon metabolism_Homo sapiens_hsa012001.57889941
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.57690293
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48622938
29Glucagon signaling pathway_Homo sapiens_hsa049221.47937142
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.39048355
31Fatty acid degradation_Homo sapiens_hsa000711.35563354
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33926119
33Nicotine addiction_Homo sapiens_hsa050331.30798459
34Pentose phosphate pathway_Homo sapiens_hsa000301.30181185
35Alcoholism_Homo sapiens_hsa050341.27782705
36PPAR signaling pathway_Homo sapiens_hsa033201.27513679
37Amphetamine addiction_Homo sapiens_hsa050311.23806426
38Base excision repair_Homo sapiens_hsa034101.19511649
39Circadian rhythm_Homo sapiens_hsa047101.18421998
40Butanoate metabolism_Homo sapiens_hsa006501.18385136
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.13309502
42Fanconi anemia pathway_Homo sapiens_hsa034601.12286855
43Endometrial cancer_Homo sapiens_hsa052131.10510140
44Non-homologous end-joining_Homo sapiens_hsa034501.10088680
45Spliceosome_Homo sapiens_hsa030401.09534734
46Arginine biosynthesis_Homo sapiens_hsa002201.07814899
47Oocyte meiosis_Homo sapiens_hsa041141.07579867
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07050446
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04963143
50Systemic lupus erythematosus_Homo sapiens_hsa053221.04548685
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03665838
52Purine metabolism_Homo sapiens_hsa002301.01311119
53Mismatch repair_Homo sapiens_hsa034301.00354638
54Inositol phosphate metabolism_Homo sapiens_hsa005620.99769184
55Cell cycle_Homo sapiens_hsa041100.96016897
56Pyrimidine metabolism_Homo sapiens_hsa002400.92657343
57mRNA surveillance pathway_Homo sapiens_hsa030150.92456144
58Basal cell carcinoma_Homo sapiens_hsa052170.90577157
59Prostate cancer_Homo sapiens_hsa052150.90082473
60Glycerolipid metabolism_Homo sapiens_hsa005610.88852851
61Regulation of autophagy_Homo sapiens_hsa041400.88402776
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88072492
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87659343
64RNA polymerase_Homo sapiens_hsa030200.86119480
65Adherens junction_Homo sapiens_hsa045200.85749970
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.85432243
67TGF-beta signaling pathway_Homo sapiens_hsa043500.84477383
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83596342
69Tryptophan metabolism_Homo sapiens_hsa003800.82875683
70Estrogen signaling pathway_Homo sapiens_hsa049150.82602461
71Bile secretion_Homo sapiens_hsa049760.82116675
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81894737
73Fatty acid elongation_Homo sapiens_hsa000620.77379495
74Caffeine metabolism_Homo sapiens_hsa002320.76397464
75RNA degradation_Homo sapiens_hsa030180.76255755
76Non-small cell lung cancer_Homo sapiens_hsa052230.72814475
77Colorectal cancer_Homo sapiens_hsa052100.72602979
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72414784
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72252122
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72061315
81Nucleotide excision repair_Homo sapiens_hsa034200.71209922
82Sphingolipid metabolism_Homo sapiens_hsa006000.67958122
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67449757
84Lysine degradation_Homo sapiens_hsa003100.67181974
85Long-term potentiation_Homo sapiens_hsa047200.66692494
86Hedgehog signaling pathway_Homo sapiens_hsa043400.63368516
87Choline metabolism in cancer_Homo sapiens_hsa052310.63090589
88Cocaine addiction_Homo sapiens_hsa050300.60898144
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60800347
90Taste transduction_Homo sapiens_hsa047420.60710839
91Peroxisome_Homo sapiens_hsa041460.59734234
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58571271
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58049820
94Fat digestion and absorption_Homo sapiens_hsa049750.57304895
95beta-Alanine metabolism_Homo sapiens_hsa004100.57113422
96Viral carcinogenesis_Homo sapiens_hsa052030.55689878
97N-Glycan biosynthesis_Homo sapiens_hsa005100.55031544
98FoxO signaling pathway_Homo sapiens_hsa040680.54520121
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54048544
100Renin-angiotensin system_Homo sapiens_hsa046140.54013193
101Platelet activation_Homo sapiens_hsa046110.53982915
102Thyroid cancer_Homo sapiens_hsa052160.53782036
103Circadian entrainment_Homo sapiens_hsa047130.53614017
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.53110272
105Retinol metabolism_Homo sapiens_hsa008300.52292511
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.52208536
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52146564
108Gap junction_Homo sapiens_hsa045400.51367624
109ABC transporters_Homo sapiens_hsa020100.51320402
110ErbB signaling pathway_Homo sapiens_hsa040120.50968172
111Tight junction_Homo sapiens_hsa045300.50597613
112Acute myeloid leukemia_Homo sapiens_hsa052210.50559464
113Phototransduction_Homo sapiens_hsa047440.50488705
114GABAergic synapse_Homo sapiens_hsa047270.50296260
115MicroRNAs in cancer_Homo sapiens_hsa052060.50191926
116Wnt signaling pathway_Homo sapiens_hsa043100.50058071
117Phenylalanine metabolism_Homo sapiens_hsa003600.48735525
118Glioma_Homo sapiens_hsa052140.48029711
119Glutamatergic synapse_Homo sapiens_hsa047240.47899296
120Serotonergic synapse_Homo sapiens_hsa047260.47505563
121Chemical carcinogenesis_Homo sapiens_hsa052040.47005893
122Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46946170
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46723151
124Long-term depression_Homo sapiens_hsa047300.45493694
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.44386720
126Ether lipid metabolism_Homo sapiens_hsa005650.43947997
127Thyroid hormone synthesis_Homo sapiens_hsa049180.43672263
128Histidine metabolism_Homo sapiens_hsa003400.42562468
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42353722
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42127062
131Complement and coagulation cascades_Homo sapiens_hsa046100.41934707
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.41045311
133AMPK signaling pathway_Homo sapiens_hsa041520.41042616
134Cyanoamino acid metabolism_Homo sapiens_hsa004600.40662710
135Starch and sucrose metabolism_Homo sapiens_hsa005000.40234499
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39798501
137Arginine and proline metabolism_Homo sapiens_hsa003300.38174839
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37683082
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37469103
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.37433938
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36881612
142Metabolic pathways_Homo sapiens_hsa011000.36152341
143Synaptic vesicle cycle_Homo sapiens_hsa047210.35294571
144Hippo signaling pathway_Homo sapiens_hsa043900.35022834
145Glutathione metabolism_Homo sapiens_hsa004800.34349008

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