NEK6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.67403374
2protein localization to endosome (GO:0036010)4.33752223
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.30313671
4peptidyl-glutamic acid carboxylation (GO:0017187)4.18686623
5protein carboxylation (GO:0018214)4.18686623
6urea metabolic process (GO:0019627)3.93383611
7urea cycle (GO:0000050)3.93383611
8pinocytosis (GO:0006907)3.89897695
9glycosphingolipid catabolic process (GO:0046479)3.85370381
10T-helper 1 type immune response (GO:0042088)3.68495129
11barbed-end actin filament capping (GO:0051016)3.68121812
12response to peptidoglycan (GO:0032494)3.67204915
13negative regulation of fibrinolysis (GO:0051918)3.64400195
14aldehyde catabolic process (GO:0046185)3.64328856
15positive regulation of extracellular matrix organization (GO:1903055)3.62705144
16tryptophan catabolic process (GO:0006569)3.61208554
17indole-containing compound catabolic process (GO:0042436)3.61208554
18indolalkylamine catabolic process (GO:0046218)3.61208554
19nitrogen cycle metabolic process (GO:0071941)3.56332899
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55736413
21L-phenylalanine metabolic process (GO:0006558)3.55736413
22amino sugar catabolic process (GO:0046348)3.53352761
23regulation of protein activation cascade (GO:2000257)3.46969419
24aromatic amino acid family catabolic process (GO:0009074)3.46037069
25glycolipid catabolic process (GO:0019377)3.44950681
26kynurenine metabolic process (GO:0070189)3.43198297
27regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.43143327
28tryptophan metabolic process (GO:0006568)3.42303796
29NIK/NF-kappaB signaling (GO:0038061)3.41369098
30myeloid dendritic cell differentiation (GO:0043011)3.40993930
31complement activation, alternative pathway (GO:0006957)3.40477646
32reverse cholesterol transport (GO:0043691)3.37468599
33detection of molecule of bacterial origin (GO:0032490)3.36889802
34regulation of fibrinolysis (GO:0051917)3.36157644
35oligosaccharide catabolic process (GO:0009313)3.35132777
36plasma lipoprotein particle clearance (GO:0034381)3.33610449
37COPI coating of Golgi vesicle (GO:0048205)3.32304792
38Golgi transport vesicle coating (GO:0048200)3.32304792
39phospholipid homeostasis (GO:0055091)3.29932446
40high-density lipoprotein particle remodeling (GO:0034375)3.29435358
41glycine metabolic process (GO:0006544)3.28768763
42regulation of complement activation (GO:0030449)3.27463061
43positive regulation of macrophage cytokine production (GO:0060907)3.22280355
44response to muramyl dipeptide (GO:0032495)3.21760723
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.20651569
46phospholipid efflux (GO:0033700)3.20218211
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.18352121
48L-phenylalanine catabolic process (GO:0006559)3.18352121
49regulation of cholesterol esterification (GO:0010872)3.18148884
50fibrinolysis (GO:0042730)3.16656713
51macrophage activation involved in immune response (GO:0002281)3.15891266
52negative regulation of interleukin-12 production (GO:0032695)3.13643481
53regulation of interferon-beta biosynthetic process (GO:0045357)3.09050099
54lipopolysaccharide-mediated signaling pathway (GO:0031663)3.08887554
55positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.08020670
56stress fiber assembly (GO:0043149)3.06635717
57Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05856717
58apoptotic cell clearance (GO:0043277)3.05752759
59mannose metabolic process (GO:0006013)3.02248694
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02055375
61regulation of triglyceride catabolic process (GO:0010896)3.01953571
62protein-lipid complex remodeling (GO:0034368)2.98909799
63macromolecular complex remodeling (GO:0034367)2.98909799
64plasma lipoprotein particle remodeling (GO:0034369)2.98909799
65positive regulation of interferon-alpha production (GO:0032727)2.97615395
66regulation of macrophage cytokine production (GO:0010935)2.96528719
67response to laminar fluid shear stress (GO:0034616)2.95160631
68serine family amino acid biosynthetic process (GO:0009070)2.95102535
69alpha-linolenic acid metabolic process (GO:0036109)2.94919075
70regulation of cholesterol storage (GO:0010885)2.93845915
71adhesion of symbiont to host (GO:0044406)2.92190248
72neutrophil activation involved in immune response (GO:0002283)2.92026887
73cellular response to thyroid hormone stimulus (GO:0097067)2.91152564
74bile acid biosynthetic process (GO:0006699)2.91126685
75myeloid dendritic cell activation (GO:0001773)2.88745632
76cholesterol efflux (GO:0033344)2.87931830
77uronic acid metabolic process (GO:0006063)2.85499399
78glucuronate metabolic process (GO:0019585)2.85499399
79immunoglobulin mediated immune response (GO:0016064)2.83562759
80negative regulation of sterol transport (GO:0032372)2.82666104
81negative regulation of cholesterol transport (GO:0032375)2.82666104
82glyoxylate metabolic process (GO:0046487)2.82639769
83virion attachment to host cell (GO:0019062)2.82289603
84adhesion of symbiont to host cell (GO:0044650)2.82289603
85positive regulation of cellular amide metabolic process (GO:0034250)2.82236888
86arginine metabolic process (GO:0006525)2.81878140
87germinal center formation (GO:0002467)2.81695518
88ceramide catabolic process (GO:0046514)2.81495132
89plasma lipoprotein particle assembly (GO:0034377)2.81458236
90cellular glucuronidation (GO:0052695)2.79471096
91sulfur amino acid catabolic process (GO:0000098)2.79182498
92peptide catabolic process (GO:0043171)2.78908704
93positive regulation of blood coagulation (GO:0030194)2.78273270
94positive regulation of hemostasis (GO:1900048)2.78273270
95lipoprotein metabolic process (GO:0042157)2.77099515
96cellular extravasation (GO:0045123)2.76622812
97regulation of interferon-alpha production (GO:0032647)2.75571923
98low-density lipoprotein particle clearance (GO:0034383)2.75441185
99NAD biosynthetic process (GO:0009435)2.75409002
100cellular response to arsenic-containing substance (GO:0071243)2.75247423
101serine family amino acid catabolic process (GO:0009071)2.74983749
102fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73427823
103skin morphogenesis (GO:0043589)2.72614023
104modulation by symbiont of host cellular process (GO:0044068)2.71599799
105wound healing, spreading of epidermal cells (GO:0035313)2.70590296
106nicotinamide nucleotide biosynthetic process (GO:0019359)2.69399259
107pyridine nucleotide biosynthetic process (GO:0019363)2.69399259
108natural killer cell mediated cytotoxicity (GO:0042267)2.69282833
109natural killer cell mediated immunity (GO:0002228)2.69282833
110negative regulation of myeloid cell apoptotic process (GO:0033033)2.68762458
111regulation of early endosome to late endosome transport (GO:2000641)2.68638398
112response to thyroid hormone (GO:0097066)2.68083794
113regulation of vitamin D biosynthetic process (GO:0060556)2.67957027
114regulation of macrophage chemotaxis (GO:0010758)2.67677949
115positive regulation of lipid catabolic process (GO:0050996)2.66567925
116detection of external biotic stimulus (GO:0098581)2.66305901
117protein-lipid complex assembly (GO:0065005)2.65603071
118aromatic amino acid family metabolic process (GO:0009072)2.65352741
119regulation of superoxide anion generation (GO:0032928)2.65038592
120acylglycerol homeostasis (GO:0055090)2.63551145
121triglyceride homeostasis (GO:0070328)2.63551145
122membrane raft organization (GO:0031579)2.62293888
123positive regulation of coagulation (GO:0050820)2.62225805
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.60302395
125homocysteine metabolic process (GO:0050667)2.59516766
126serine family amino acid metabolic process (GO:0009069)2.58530873
127cysteine metabolic process (GO:0006534)2.58108138
128dendritic cell differentiation (GO:0097028)2.57532089
129positive regulation by symbiont of host defense response (GO:0052509)2.56954631
130modulation by symbiont of host defense response (GO:0052031)2.56954631
131modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56954631
132modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56954631
133positive regulation by organism of defense response of other organism involved in symbiotic interact2.56954631
134modulation by symbiont of host immune response (GO:0052553)2.56954631
135response to host (GO:0075136)2.56917033
136response to host defenses (GO:0052200)2.56917033
137response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.56917033
138interferon-gamma-mediated signaling pathway (GO:0060333)2.56088494
139response to nitrosative stress (GO:0051409)2.56074227
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.55663247
141negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.55607061
142regulation of mononuclear cell migration (GO:0071675)2.54994015
143regulation of cytokine secretion involved in immune response (GO:0002739)2.54684907
144protein retention in ER lumen (GO:0006621)2.54382526
145regulation of extracellular matrix organization (GO:1903053)2.53284037
146amine catabolic process (GO:0009310)2.53202390
147cellular biogenic amine catabolic process (GO:0042402)2.53202390
148acute-phase response (GO:0006953)2.53125218
149response to growth hormone (GO:0060416)2.52597664
150regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.52281492
151response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51835345
152response to host immune response (GO:0052572)2.51835345
153bile acid metabolic process (GO:0008206)2.51777958
154positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.49202000
155regulation of monocyte differentiation (GO:0045655)2.48463233
156plasma lipoprotein particle organization (GO:0071827)2.48366044
157positive regulation of gamma-delta T cell activation (GO:0046645)2.48121473
158regulation of podosome assembly (GO:0071801)2.47850625
159osteoclast differentiation (GO:0030316)2.47591537
160N-acetylneuraminate metabolic process (GO:0006054)2.47381781
161regulation of heterotypic cell-cell adhesion (GO:0034114)2.47232751
162cholesterol homeostasis (GO:0042632)2.46806833
163positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.45472178
164L-serine metabolic process (GO:0006563)2.45088239
165sterol homeostasis (GO:0055092)2.45019423
166bile acid and bile salt transport (GO:0015721)2.44509137
167positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)2.43458556
168positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42411532
169cell adhesion mediated by integrin (GO:0033627)2.42349127
170growth hormone receptor signaling pathway (GO:0060396)2.41869077
171protein activation cascade (GO:0072376)2.41686023
172regulation of plasminogen activation (GO:0010755)2.41655546
173cytokine secretion (GO:0050663)2.41543536
174bone resorption (GO:0045453)2.41285112
175detection of other organism (GO:0098543)2.40212694
176cortical actin cytoskeleton organization (GO:0030866)2.39267324
177CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34750082
178regulation of membrane protein ectodomain proteolysis (GO:0051043)2.34592580
179dicarboxylic acid biosynthetic process (GO:0043650)2.33732339
180detection of biotic stimulus (GO:0009595)2.31361688
181modification by symbiont of host morphology or physiology (GO:0044003)2.30989846
182membrane lipid catabolic process (GO:0046466)2.30523580
183cellular response to type I interferon (GO:0071357)2.30453448
184type I interferon signaling pathway (GO:0060337)2.30453448
185hyaluronan catabolic process (GO:0030214)2.30169831
186regulation of type I interferon-mediated signaling pathway (GO:0060338)2.28050854
187response to type I interferon (GO:0034340)2.27904039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.03380216
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.31899137
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.06412622
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.95524151
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60191121
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.53232159
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.45077400
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.18780976
9TP63_17297297_ChIP-ChIP_HaCaT_Human3.16714521
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.14551897
11E2F7_22180533_ChIP-Seq_HELA_Human2.99567608
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.89646085
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.57269492
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45544710
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.40577393
16TRIM28_21343339_ChIP-Seq_HEK293_Human2.39156973
17* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.36217861
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33957228
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28811735
20TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.25594933
21* MYC_22102868_ChIP-Seq_BL_Human2.24808544
22* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17422542
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15728335
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12818219
25* LXR_22292898_ChIP-Seq_THP-1_Human2.09877156
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08482700
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97331224
28* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96805275
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92991167
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92493969
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.88432408
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84221448
33* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.79178438
34HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.76676203
35CLOCK_20551151_ChIP-Seq_293T_Human1.67065231
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66009602
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.65009378
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63867683
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63610647
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62796652
41NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.62464638
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61362921
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55193939
44TCF7_22412390_ChIP-Seq_EML_Mouse1.53649934
45SPI1_23127762_ChIP-Seq_K562_Human1.53566235
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52661859
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.50946603
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50233412
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48302878
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.44008965
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.41976941
52* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41023297
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40603729
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.38220061
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37687642
56RACK7_27058665_Chip-Seq_MCF-7_Human1.37261684
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34954608
58* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34701279
59SALL4_18804426_ChIP-ChIP_XEN_Mouse1.34581502
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32696225
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.31608364
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30870059
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.30756172
64KDM2B_26808549_Chip-Seq_DND41_Human1.30402657
65CDX2_20551321_ChIP-Seq_CACO-2_Human1.30292817
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.27801465
67TP53_22127205_ChIP-Seq_IMR90_Human1.26738829
68AR_21909140_ChIP-Seq_LNCAP_Human1.25716978
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.24830028
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24411618
71* SPI1_23547873_ChIP-Seq_NB4_Human1.23997471
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.23011646
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21157414
74VDR_24763502_ChIP-Seq_THP-1_Human1.19752823
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18360845
76ZNF263_19887448_ChIP-Seq_K562_Human1.17790066
77* GATA1_19941827_ChIP-Seq_MEL_Mouse1.17326056
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16473547
79SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16431827
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.15472934
81* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.13001915
82* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.13001915
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12816468
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12293288
85* ELK3_25401928_ChIP-Seq_HUVEC_Human1.10382554
86* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09974630
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09950397
88DCP1A_22483619_ChIP-Seq_HELA_Human1.09765904
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09625889
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09514387
91* SOX2_20726797_ChIP-Seq_SW620_Human1.09155038
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08969797
93* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07681424
94BP1_19119308_ChIP-ChIP_Hs578T_Human1.07370294
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07010151
96* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06976047
97TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04964699
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.04840165
99* PU_27001747_Chip-Seq_BMDM_Mouse1.04829877
100* MAF_26560356_Chip-Seq_TH1_Human1.03842234
101KDM2B_26808549_Chip-Seq_K562_Human1.03283204
102* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02455846
103MAF_26560356_Chip-Seq_TH2_Human1.02451778
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01817762
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01613811
106HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99417838
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98945041
108* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.98025235
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97975901
110* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97936567
111ATF3_27146783_Chip-Seq_COLON_Human0.97811500
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97113960
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96726418
114UTX_26944678_Chip-Seq_JUKART_Human0.95972014
115* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95443827
116* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95033363
117VDR_21846776_ChIP-Seq_THP-1_Human0.94193457
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93859032
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93731660
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91997076
121GATA4_25053715_ChIP-Seq_YYC3_Human0.91526759
122E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91246355
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90545017
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90348974
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87209935
126CREB1_15753290_ChIP-ChIP_HEK293T_Human0.87186249
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86789660
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.86767320
129* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.86185892
130NELFA_20434984_ChIP-Seq_ESCs_Mouse0.85740750
131GATA6_25053715_ChIP-Seq_YYC3_Human0.85451943
132TFEB_21752829_ChIP-Seq_HELA_Human0.85339167
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84770572
134* VDR_24787735_ChIP-Seq_THP-1_Human0.84412362
135NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83898883
136NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83898883
137TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83227044
138E2F1_21310950_ChIP-Seq_MCF-7_Human0.83035883
139CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82600445
140XRN2_22483619_ChIP-Seq_HELA_Human0.81741113
141SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81276755
142FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.80858624

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.09527851
2MP0005360_urolithiasis3.84027111
3MP0009840_abnormal_foam_cell3.12856502
4MP0005085_abnormal_gallbladder_physiolo2.96393796
5MP0005451_abnormal_body_composition2.82554647
6MP0008438_abnormal_cutaneous_collagen2.81588743
7MP0003705_abnormal_hypodermis_morpholog2.73930351
8MP0002138_abnormal_hepatobiliary_system2.73081032
9MP0005365_abnormal_bile_salt2.48843689
10MP0003252_abnormal_bile_duct2.41865089
11MP0003172_abnormal_lysosome_physiology2.40352088
12MP0002877_abnormal_melanocyte_morpholog2.38659255
13MP0000604_amyloidosis2.26903776
14MP0009053_abnormal_anal_canal2.23413461
15MP0003436_decreased_susceptibility_to2.21765016
16MP0003191_abnormal_cellular_cholesterol2.12383737
17MP0003303_peritoneal_inflammation2.04937568
18MP0010329_abnormal_lipoprotein_level2.04639957
19MP0001835_abnormal_antigen_presentation1.99993096
20MP0003724_increased_susceptibility_to1.95305386
21MP0005257_abnormal_intraocular_pressure1.91553194
22MP0003011_delayed_dark_adaptation1.79132379
23MP0008875_abnormal_xenobiotic_pharmacok1.70439818
24MP0003075_altered_response_to1.66226009
25MP0008260_abnormal_autophagy1.65504267
26MP0003183_abnormal_peptide_metabolism1.62859164
27MP0009785_altered_susceptibility_to1.62631122
28MP0005503_abnormal_tendon_morphology1.57829935
29MP0003300_gastrointestinal_ulcer1.55835670
30MP0003329_amyloid_beta_deposits1.54843454
31MP0009379_abnormal_foot_pigmentation1.54551689
32MP0002419_abnormal_innate_immunity1.52812697
33MP0001958_emphysema1.51039984
34MP0009764_decreased_sensitivity_to1.50092354
35MP0005083_abnormal_biliary_tract1.48428180
36MP0004510_myositis1.46564742
37MP0004947_skin_inflammation1.41472835
38MP0004019_abnormal_vitamin_homeostasis1.39197724
39MP0005623_abnormal_meninges_morphology1.36662586
40MP0000858_altered_metastatic_potential1.35195684
41MP0002148_abnormal_hypersensitivity_rea1.33977812
42MP0005058_abnormal_lysosome_morphology1.32483982
43MP0006082_CNS_inflammation1.31776719
44MP0001533_abnormal_skeleton_physiology1.31760295
45MP0000609_abnormal_liver_physiology1.31746146
46MP0003186_abnormal_redox_activity1.30890874
47MP0000569_abnormal_digit_pigmentation1.29776725
48MP0003279_aneurysm1.29225564
49MP0005025_abnormal_response_to1.28613401
50MP0001666_abnormal_nutrient_absorption1.28162097
51MP0003448_altered_tumor_morphology1.27136652
52MP0004858_abnormal_nervous_system1.25077016
53MP0005076_abnormal_cell_differentiation1.24516888
54MP0004233_abnormal_muscle_weight1.23128157
55MP0008469_abnormal_protein_level1.21603593
56MP0005023_abnormal_wound_healing1.20291932
57MP0010368_abnormal_lymphatic_system1.19843168
58MP0005332_abnormal_amino_acid1.18778753
59MP0009278_abnormal_bone_marrow1.18691268
60MP0005248_abnormal_Harderian_gland1.17991323
61MP0009697_abnormal_copulation1.17371846
62MP0001849_ear_inflammation1.12711417
63MP0000685_abnormal_immune_system1.12176203
64MP0003566_abnormal_cell_adhesion1.11703315
65MP0003656_abnormal_erythrocyte_physiolo1.09658906
66MP0005275_abnormal_skin_tensile1.09077584
67MP0004782_abnormal_surfactant_physiolog1.08713475
68MP0009763_increased_sensitivity_to1.08026944
69MP0000598_abnormal_liver_morphology1.05605852
70MP0003806_abnormal_nucleotide_metabolis1.01884428
71MP0002452_abnormal_antigen_presenting1.00066702
72MP0005000_abnormal_immune_tolerance0.99381539
73MP0005084_abnormal_gallbladder_morpholo0.98652859
74MP0002896_abnormal_bone_mineralization0.97799624
75MP0005167_abnormal_blood-brain_barrier0.97257120
76MP0009333_abnormal_splenocyte_physiolog0.97146506
77MP0005319_abnormal_enzyme/_coenzyme0.96807355
78MP0005390_skeleton_phenotype0.96773511
79MP0001915_intracranial_hemorrhage0.96732188
80MP0002254_reproductive_system_inflammat0.96301291
81MP0005310_abnormal_salivary_gland0.96059259
82MP0009384_cardiac_valve_regurgitation0.95403033
83MP0003690_abnormal_glial_cell0.94319008
84MP0004272_abnormal_basement_membrane0.94289931
85MP0000716_abnormal_immune_system0.94127359
86MP0000920_abnormal_myelination0.94090688
87MP0002282_abnormal_trachea_morphology0.92937833
88MP0003091_abnormal_cell_migration0.92932638
89MP0001845_abnormal_inflammatory_respons0.92833399
90MP0010030_abnormal_orbit_morphology0.92399862
91MP0005464_abnormal_platelet_physiology0.92338021
92MP0003195_calcinosis0.91679170
93MP0005387_immune_system_phenotype0.90761413
94MP0001790_abnormal_immune_system0.90761413
95MP0000343_altered_response_to0.89737619
96MP0010155_abnormal_intestine_physiology0.87912587
97MP0003453_abnormal_keratinocyte_physiol0.86573466
98MP0000767_abnormal_smooth_muscle0.86291987
99MP0002118_abnormal_lipid_homeostasis0.85375125
100MP0005397_hematopoietic_system_phenotyp0.85140845
101MP0001545_abnormal_hematopoietic_system0.85140845
102MP0003950_abnormal_plasma_membrane0.84258450
103MP0010352_gastrointestinal_tract_polyps0.83941986
104MP0001853_heart_inflammation0.83224244
105MP0000371_diluted_coat_color0.82920999
106MP0003634_abnormal_glial_cell0.82495787
107MP0002998_abnormal_bone_remodeling0.82113990
108MP0002723_abnormal_immune_serum0.81712935
109MP0003795_abnormal_bone_structure0.81297096
110MP0000249_abnormal_blood_vessel0.80918576
111MP0001800_abnormal_humoral_immune0.80886953
112MP0004883_abnormal_blood_vessel0.79989705
113MP0005165_increased_susceptibility_to0.78884073
114MP0002405_respiratory_system_inflammati0.78298319
115MP0002398_abnormal_bone_marrow0.77991521
116MP0001542_abnormal_bone_strength0.77819629
117MP0005621_abnormal_cell_physiology0.77230271
118MP0002429_abnormal_blood_cell0.76430610
119MP0002295_abnormal_pulmonary_circulatio0.76068412
120MP0005164_abnormal_response_to0.75640416
121MP0002166_altered_tumor_susceptibility0.74625205
122MP0002089_abnormal_postnatal_growth/wei0.74598719
123MP0005671_abnormal_response_to0.72163164
124MP0005508_abnormal_skeleton_morphology0.71691256
125MP0001819_abnormal_immune_cell0.71625830
126MP0006054_spinal_hemorrhage0.70273449
127MP0001243_abnormal_dermal_layer0.69734098
128MP0008874_decreased_physiological_sensi0.68767512
129MP0008007_abnormal_cellular_replicative0.68764878
130MP0002420_abnormal_adaptive_immunity0.68748768
131MP0000733_abnormal_muscle_development0.68485711
132MP0005166_decreased_susceptibility_to0.68281310
133MP0002060_abnormal_skin_morphology0.68046528
134MP0002933_joint_inflammation0.66823681
135MP0000689_abnormal_spleen_morphology0.66113314
136MP0000627_abnormal_mammary_gland0.66104246
137MP0005197_abnormal_uvea_morphology0.66068743

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.15916560
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.15916560
3Abnormality of glycolipid metabolism (HP:0010969)5.15916560
4Deep venous thrombosis (HP:0002625)4.31922605
5Recurrent gram-negative bacterial infections (HP:0005420)4.18579492
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.15913533
7Myocardial infarction (HP:0001658)4.13177393
8Complement deficiency (HP:0004431)4.04581554
9Xanthomatosis (HP:0000991)3.99168952
10Protrusio acetabuli (HP:0003179)3.95489410
11Abnormality of complement system (HP:0005339)3.89973522
12Dysostosis multiplex (HP:0000943)3.78787481
13Peritonitis (HP:0002586)3.76191004
14Hypobetalipoproteinemia (HP:0003563)3.74568882
15Hypoalphalipoproteinemia (HP:0003233)3.70869736
16Systemic lupus erythematosus (HP:0002725)3.63437247
17Intrahepatic cholestasis (HP:0001406)3.61063471
18Hypolipoproteinemia (HP:0010981)3.59402159
19Joint hemorrhage (HP:0005261)3.58632763
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.54654203
21Prolonged partial thromboplastin time (HP:0003645)3.36339908
22Premature rupture of membranes (HP:0001788)3.35771465
23Abnormality of pyrimidine metabolism (HP:0004353)3.25260478
24Vertebral compression fractures (HP:0002953)3.21179240
25Glomerulonephritis (HP:0000099)3.15224170
26Eczematoid dermatitis (HP:0000976)3.12770850
27Abnormality of glutamine family amino acid metabolism (HP:0010902)3.11829124
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.07236328
29Mucopolysacchariduria (HP:0008155)2.98345358
30Urinary glycosaminoglycan excretion (HP:0003541)2.98345358
31Esophageal varix (HP:0002040)2.95191187
32Loss of speech (HP:0002371)2.91636372
33Vacuolated lymphocytes (HP:0001922)2.89585504
34Gastrointestinal stroma tumor (HP:0100723)2.89034440
35Hyperlipoproteinemia (HP:0010980)2.88168848
36Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86673592
37Abnormality of polysaccharide metabolism (HP:0011012)2.86673592
38Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86673592
39Recurrent bacterial skin infections (HP:0005406)2.82338764
40Recurrent abscess formation (HP:0002722)2.81862272
41Gingival bleeding (HP:0000225)2.70305032
42Hyperacusis (HP:0010780)2.69955412
43Nuclear cataract (HP:0100018)2.69289011
44Neurofibrillary tangles (HP:0002185)2.68101300
45Abnormality of the common coagulation pathway (HP:0010990)2.65073432
46Periodontitis (HP:0000704)2.57891875
47Biconcave vertebral bodies (HP:0004586)2.57088265
48Emphysema (HP:0002097)2.52115778
49Epidermoid cyst (HP:0200040)2.51383886
50Gingivitis (HP:0000230)2.50292115
51Abnormal hemoglobin (HP:0011902)2.50102358
52Upper motor neuron abnormality (HP:0002127)2.46398996
53Elevated erythrocyte sedimentation rate (HP:0003565)2.43187478
54Spondylolisthesis (HP:0003302)2.40752474
55Hyperglycinemia (HP:0002154)2.38226040
56Nephritis (HP:0000123)2.36898197
57Cellulitis (HP:0100658)2.36162135
58Purpura (HP:0000979)2.36130159
59Mediastinal lymphadenopathy (HP:0100721)2.35273089
60Vascular tortuosity (HP:0004948)2.34854670
61Increased cerebral lipofuscin (HP:0011813)2.32823747
62Abnormality of macrophages (HP:0004311)2.30783397
63Cardiovascular calcification (HP:0011915)2.29483652
64Fat malabsorption (HP:0002630)2.28761248
65Mitral stenosis (HP:0001718)2.27945383
66Urticaria (HP:0001025)2.26339997
67Cerebral inclusion bodies (HP:0100314)2.25842806
68Arterial tortuosity (HP:0005116)2.24802120
69Hypercholesterolemia (HP:0003124)2.22897793
70Thoracic kyphosis (HP:0002942)2.20033567
71Hyperammonemia (HP:0001987)2.19118552
72Disinhibition (HP:0000734)2.18575663
73Pathologic fracture (HP:0002756)2.18172123
74Natal tooth (HP:0000695)2.17264266
75Recurrent skin infections (HP:0001581)2.16392975
76Conjugated hyperbilirubinemia (HP:0002908)2.16295853
77Vascular calcification (HP:0004934)2.15763736
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.15334205
79Autoimmune thrombocytopenia (HP:0001973)2.12875941
80Spinal cord lesions (HP:0100561)2.12407291
81Syringomyelia (HP:0003396)2.12407291
82Bladder diverticulum (HP:0000015)2.10798722
83Mitral valve prolapse (HP:0001634)2.08764625
84Soft skin (HP:0000977)2.08596563
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04849802
86Shallow orbits (HP:0000586)2.03913761
87Menorrhagia (HP:0000132)2.01477593
88Hydroxyprolinuria (HP:0003080)2.01253696
89Abnormality of proline metabolism (HP:0010907)2.01253696
90Nausea (HP:0002018)2.00600037
91Neonatal short-limb short stature (HP:0008921)1.99543485
92Axonal loss (HP:0003447)1.98524404
93Restrictive lung disease (HP:0002091)1.98287890
94Abnormality of sulfur amino acid metabolism (HP:0004339)1.97123244
95Genu recurvatum (HP:0002816)1.96081958
96Abnormality of the Achilles tendon (HP:0005109)1.93899343
97Cerebral aneurysm (HP:0004944)1.93488025
98Abnormality of the thoracic spine (HP:0100711)1.92984821
99Abnormal delivery (HP:0001787)1.92332811
100Abnormality of nucleobase metabolism (HP:0010932)1.92126962
101Delayed CNS myelination (HP:0002188)1.90880437
102Skin nodule (HP:0200036)1.90083589
103Interstitial pulmonary disease (HP:0006530)1.89793020
104Ovoid vertebral bodies (HP:0003300)1.89698243
105Osteolytic defects of the hand bones (HP:0009699)1.89691643
106Osteolytic defects of the phalanges of the hand (HP:0009771)1.89691643
107Blue sclerae (HP:0000592)1.89226078
108Abnormality of the lumbar spine (HP:0100712)1.88210295
109Apathy (HP:0000741)1.87512068
110Dilatation of the ascending aorta (HP:0005111)1.86477511
111Amyloidosis (HP:0011034)1.85650693
112Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84638643
113Multiple lipomas (HP:0001012)1.84284943
114IgA deficiency (HP:0002720)1.83510497
115Spontaneous abortion (HP:0005268)1.83035556
116Diminished motivation (HP:0000745)1.82874650
117Cupped ribs (HP:0000887)1.82721394
118Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.82529415
119Thin bony cortex (HP:0002753)1.82005670
120Wormian bones (HP:0002645)1.81539530
121Prolonged neonatal jaundice (HP:0006579)1.81207030
122Ankle contracture (HP:0006466)1.79423624
123Hepatosplenomegaly (HP:0001433)1.78695832
124Mitral regurgitation (HP:0001653)1.78624188
125Neuronal loss in central nervous system (HP:0002529)1.78515208
126Abnormality of serum amino acid levels (HP:0003112)1.77524966
127Acrocyanosis (HP:0001063)1.76883486
128Hematochezia (HP:0002573)1.76721535
129Flat acetabular roof (HP:0003180)1.76618188
130Conjunctival telangiectasia (HP:0000524)1.76213041
131Abnormality of methionine metabolism (HP:0010901)1.75802348
132Hemorrhage of the eye (HP:0011885)1.74706419
133Basal ganglia calcification (HP:0002135)1.74686951
134Abnormality of the peritoneum (HP:0002585)1.74663823
135Cervical subluxation (HP:0003308)1.74555012
136Hepatocellular carcinoma (HP:0001402)1.74014910
137Abnormality of serine family amino acid metabolism (HP:0010894)1.73489566
138Abnormality of glycine metabolism (HP:0010895)1.73489566
139Vasculitis (HP:0002633)1.73295861
140Colitis (HP:0002583)1.72188167
141Hyperglycinuria (HP:0003108)1.70930295
142Polycythemia (HP:0001901)1.70912171
143Recurrent viral infections (HP:0004429)1.69935190
144Aortic dissection (HP:0002647)1.68998637
145Short nail (HP:0001799)1.68024462
146Bone pain (HP:0002653)1.67955068
147Increased mean platelet volume (HP:0011877)1.67827912
148Personality changes (HP:0000751)1.67292183
149Protuberant abdomen (HP:0001538)1.66301743
150Insomnia (HP:0100785)1.66177010
151Steatorrhea (HP:0002570)1.65554158
152Increased serum ferritin (HP:0003281)1.65425055
153Recurrent lower respiratory tract infections (HP:0002783)1.64424936
154Viral hepatitis (HP:0006562)1.64071359
155Achilles tendon contracture (HP:0001771)1.63503567
156Segmental peripheral demyelination/remyelination (HP:0003481)1.63467623
157Recurrent fungal infections (HP:0002841)1.63236142
158Aortic aneurysm (HP:0004942)1.62183553
159Pulmonary infiltrates (HP:0002113)1.61397691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.48344850
2NME23.55208379
3PRPF4B3.19553270
4BLK2.93407736
5IRAK32.70657655
6EIF2AK12.70446812
7ERN12.35523286
8PBK2.27949438
9RIPK42.27520358
10SMG12.19346331
11TBK12.14938255
12PIM22.14912999
13MAP3K142.08143515
14TRIB32.06969917
15MAP3K112.04383891
16IRAK42.02557902
17EPHA22.00141465
18RPS6KA41.98713295
19ICK1.81575831
20MAP3K131.76966211
21EPHA31.75709416
22TYK21.69583150
23TAOK21.64307925
24CDC42BPA1.64196602
25FLT31.58465276
26TESK21.57645690
27CDK121.56398739
28PKN21.55826270
29KDR1.50540938
30NUAK11.46699601
31EPHB21.46485927
32ABL21.44518612
33SIK11.42496665
34PTK61.38629031
35FGFR41.37964221
36PAK41.37194497
37ARAF1.33649133
38TGFBR21.32919692
39FGR1.32618545
40EEF2K1.30066093
41MAP4K11.29275346
42IKBKB1.28865938
43RIPK11.26509192
44TTN1.24976439
45CDK61.23650878
46DYRK1B1.21916252
47BCKDK1.15570722
48KIT1.12024588
49MAP3K101.11678355
50TAOK31.11221653
51JAK31.10082325
52TESK11.06988224
53MATK1.06517968
54IRAK11.03790685
55ZAP701.02130084
56* NEK91.00441393
57DAPK30.98343125
58MAP3K50.98277367
59MKNK20.98145515
60BUB10.96487902
61KSR20.94782505
62CHUK0.92059140
63FRK0.85401046
64MAP3K80.84604530
65EIF2AK20.83083628
66CSF1R0.83067052
67SIK20.81566417
68CSK0.81472850
69JAK10.81194956
70GRK70.79691131
71MAP3K30.79204221
72BMX0.78985792
73DDR20.78534336
74CAMK1G0.77577218
75IKBKE0.77331621
76PAK20.77179393
77MAPK110.76592102
78PDPK10.76493509
79LATS10.75156457
80SCYL20.75101382
81MST1R0.74490258
82CDK80.73842938
83MAP2K30.73195446
84LATS20.72093328
85SYK0.71388157
86PDGFRB0.70387309
87BMPR20.69969168
88MELK0.69308684
89MAP3K10.68491731
90ROCK20.68236555
91PRKD20.67212628
92RPS6KA20.66770117
93MAP2K20.66745560
94MAPK70.66610545
95ERBB20.66081629
96DYRK30.62318281
97MTOR0.61624211
98ERBB40.61143079
99MKNK10.60691162
100FER0.59740845
101PTK20.59263371
102JAK20.57904961
103MOS0.57870232
104LMTK20.57727425
105TAOK10.55243941
106PIM10.54454113
107LIMK10.53581806
108CDK90.51723122
109HCK0.51656153
110LYN0.50155917
111STK240.49725126
112CDK40.48451091
113YES10.47881295
114ABL10.47730621
115SRPK10.47677677
116STK40.47195432
117NTRK10.46516168
118PRKD30.45459689
119EGFR0.45256830
120MAPKAPK20.45251359
121PRKCD0.45195318
122TYRO30.44568763
123EPHB10.44121925
124TRPM70.43467530
125CAMKK20.43066047
126PDK10.43015611
127RPS6KC10.42927491
128RPS6KL10.42927491
129BTK0.42507481
130ERBB30.41513674
131IRAK20.41236439
132CDK70.40390643
133CAMK1D0.39212004
134STK100.39174196
135NLK0.38428357
136ILK0.38095383
137PIK3CG0.37133162
138FGFR30.36754344
139TEC0.36492736
140AURKB0.36355131
141HIPK20.36043235
142LRRK20.35982327
143SIK30.35968189
144STK38L0.35873047
145PDGFRA0.34238744

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.24273731
2Complement and coagulation cascades_Homo sapiens_hsa046102.95464158
3Nitrogen metabolism_Homo sapiens_hsa009102.90665310
4Staphylococcus aureus infection_Homo sapiens_hsa051502.84110993
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78316014
6Pentose and glucuronate interconversions_Homo sapiens_hsa000402.51428422
7Arginine biosynthesis_Homo sapiens_hsa002202.17975629
8One carbon pool by folate_Homo sapiens_hsa006701.97913326
9Tryptophan metabolism_Homo sapiens_hsa003801.94867179
10Allograft rejection_Homo sapiens_hsa053301.94009986
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91346770
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86824858
13B cell receptor signaling pathway_Homo sapiens_hsa046621.86746438
14Caffeine metabolism_Homo sapiens_hsa002321.69680882
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68105295
16Asthma_Homo sapiens_hsa053101.62340528
17Fatty acid degradation_Homo sapiens_hsa000711.61826860
18Autoimmune thyroid disease_Homo sapiens_hsa053201.53814391
19Sulfur relay system_Homo sapiens_hsa041221.52574359
20Graft-versus-host disease_Homo sapiens_hsa053321.49432204
21Folate biosynthesis_Homo sapiens_hsa007901.48474835
22Rheumatoid arthritis_Homo sapiens_hsa053231.48354589
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44611770
24PPAR signaling pathway_Homo sapiens_hsa033201.41004246
25Leishmaniasis_Homo sapiens_hsa051401.38051891
26Retinol metabolism_Homo sapiens_hsa008301.37826438
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.37416534
28Peroxisome_Homo sapiens_hsa041461.30632240
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29652304
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29019370
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26941580
32Fat digestion and absorption_Homo sapiens_hsa049751.26811770
33Malaria_Homo sapiens_hsa051441.22499833
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21481878
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21308453
36Legionellosis_Homo sapiens_hsa051341.20481263
37Fructose and mannose metabolism_Homo sapiens_hsa000511.20188288
38Pertussis_Homo sapiens_hsa051331.17792772
39Starch and sucrose metabolism_Homo sapiens_hsa005001.17197755
40Chemical carcinogenesis_Homo sapiens_hsa052041.15104869
41Histidine metabolism_Homo sapiens_hsa003401.13954134
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13212094
43Selenocompound metabolism_Homo sapiens_hsa004501.12343443
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11348125
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10722770
46Pancreatic cancer_Homo sapiens_hsa052121.09307875
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09023354
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07252077
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.06098486
50Steroid biosynthesis_Homo sapiens_hsa001001.05634058
51Bladder cancer_Homo sapiens_hsa052191.03993945
52Amoebiasis_Homo sapiens_hsa051460.97991833
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.97595018
54Lysosome_Homo sapiens_hsa041420.96010151
55Type I diabetes mellitus_Homo sapiens_hsa049400.94842439
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94104093
57Other glycan degradation_Homo sapiens_hsa005110.93973344
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92763213
59Ribosome_Homo sapiens_hsa030100.92690454
60Acute myeloid leukemia_Homo sapiens_hsa052210.91857070
61Renal cell carcinoma_Homo sapiens_hsa052110.91595229
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.90990610
63Vitamin digestion and absorption_Homo sapiens_hsa049770.90935750
64beta-Alanine metabolism_Homo sapiens_hsa004100.89880640
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.88870204
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.88597623
67Focal adhesion_Homo sapiens_hsa045100.85662151
68Osteoclast differentiation_Homo sapiens_hsa043800.85179781
69Proteoglycans in cancer_Homo sapiens_hsa052050.83694171
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82765391
71Vibrio cholerae infection_Homo sapiens_hsa051100.82315362
72Measles_Homo sapiens_hsa051620.80446352
73Apoptosis_Homo sapiens_hsa042100.78462451
74TNF signaling pathway_Homo sapiens_hsa046680.78031222
75Tuberculosis_Homo sapiens_hsa051520.77366403
76HIF-1 signaling pathway_Homo sapiens_hsa040660.74040120
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.73712748
78Non-small cell lung cancer_Homo sapiens_hsa052230.73644218
79Influenza A_Homo sapiens_hsa051640.73302234
80Hematopoietic cell lineage_Homo sapiens_hsa046400.73176756
81DNA replication_Homo sapiens_hsa030300.73019688
82Notch signaling pathway_Homo sapiens_hsa043300.72143605
83Chemokine signaling pathway_Homo sapiens_hsa040620.70978915
84Shigellosis_Homo sapiens_hsa051310.68416176
85Galactose metabolism_Homo sapiens_hsa000520.68113689
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67935842
87Herpes simplex infection_Homo sapiens_hsa051680.67720229
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67444913
89Epstein-Barr virus infection_Homo sapiens_hsa051690.66244557
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64937762
91Glutathione metabolism_Homo sapiens_hsa004800.64373086
92Viral myocarditis_Homo sapiens_hsa054160.63687983
93Antigen processing and presentation_Homo sapiens_hsa046120.63588630
94Viral carcinogenesis_Homo sapiens_hsa052030.63435915
95Biosynthesis of amino acids_Homo sapiens_hsa012300.63407328
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62802799
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.62401026
98Fatty acid metabolism_Homo sapiens_hsa012120.62001427
99Systemic lupus erythematosus_Homo sapiens_hsa053220.61717886
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61204741
101Toxoplasmosis_Homo sapiens_hsa051450.60860626
102Phagosome_Homo sapiens_hsa041450.60382469
103HTLV-I infection_Homo sapiens_hsa051660.60139885
104Proteasome_Homo sapiens_hsa030500.59755752
105Hepatitis C_Homo sapiens_hsa051600.59598802
106Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59273791
107Tyrosine metabolism_Homo sapiens_hsa003500.59168246
108African trypanosomiasis_Homo sapiens_hsa051430.59160478
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59133248
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59071132
111VEGF signaling pathway_Homo sapiens_hsa043700.58972536
112Carbon metabolism_Homo sapiens_hsa012000.58334775
113Prolactin signaling pathway_Homo sapiens_hsa049170.57830741
114Phenylalanine metabolism_Homo sapiens_hsa003600.57660388
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.57184751
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55413712
117Hepatitis B_Homo sapiens_hsa051610.55034077
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55002711
119Primary immunodeficiency_Homo sapiens_hsa053400.54891995
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53792620
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53197933
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52482694
123Chronic myeloid leukemia_Homo sapiens_hsa052200.51617251
124Pentose phosphate pathway_Homo sapiens_hsa000300.51301356
125Sphingolipid metabolism_Homo sapiens_hsa006000.51079691
126Prostate cancer_Homo sapiens_hsa052150.51077944
127Endocytosis_Homo sapiens_hsa041440.50743920
128p53 signaling pathway_Homo sapiens_hsa041150.50543685
129Endometrial cancer_Homo sapiens_hsa052130.49057209
130Lysine degradation_Homo sapiens_hsa003100.48436798
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.48211447
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47700747
133ECM-receptor interaction_Homo sapiens_hsa045120.47631472
134Salmonella infection_Homo sapiens_hsa051320.47626820
135Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47579747
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47511232
137Bile secretion_Homo sapiens_hsa049760.46734031
138Small cell lung cancer_Homo sapiens_hsa052220.46257099
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.46103243
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.45669598
141MicroRNAs in cancer_Homo sapiens_hsa052060.45601015
142Intestinal immune network for IgA production_Homo sapiens_hsa046720.45313209
143Prion diseases_Homo sapiens_hsa050200.45068393
144Renin-angiotensin system_Homo sapiens_hsa046140.44930018
145Butanoate metabolism_Homo sapiens_hsa006500.43405620
146Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41949742
147Sulfur metabolism_Homo sapiens_hsa009200.40489973
148Pyrimidine metabolism_Homo sapiens_hsa002400.39340308

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