NEK7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)4.48558463
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.43652937
3sequestering of extracellular ligand from receptor (GO:0035581)4.28018365
4endodermal cell differentiation (GO:0035987)3.67956152
5cell-substrate junction assembly (GO:0007044)3.55385018
6antigen processing and presentation of endogenous antigen (GO:0019883)3.42172206
7cell migration involved in heart development (GO:0060973)3.39521074
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.35141784
9antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.35141784
10extracellular fibril organization (GO:0043206)3.34701814
11stress fiber assembly (GO:0043149)3.30406142
12extracellular matrix assembly (GO:0085029)3.28118665
13fibril organization (GO:0097435)3.26994106
14sarcomere organization (GO:0045214)3.22268081
15protein localization to endosome (GO:0036010)3.21628478
16type B pancreatic cell proliferation (GO:0044342)3.18403463
17positive regulation of blood vessel endothelial cell migration (GO:0043536)3.18182890
18positive regulation of receptor recycling (GO:0001921)3.13636332
19positive regulation of endothelial cell apoptotic process (GO:2000353)3.12830046
20protein heterotrimerization (GO:0070208)3.12382986
21positive regulation of fibroblast migration (GO:0010763)3.06150298
22positive regulation of natural killer cell differentiation (GO:0032825)3.03182774
23cellular response to epinephrine stimulus (GO:0071872)3.00835903
24focal adhesion assembly (GO:0048041)2.98372589
25cell-substrate adherens junction assembly (GO:0007045)2.98372589
26positive regulation of interferon-alpha production (GO:0032727)2.97978910
27actin-mediated cell contraction (GO:0070252)2.97527008
28barbed-end actin filament capping (GO:0051016)2.97090395
29growth hormone receptor signaling pathway (GO:0060396)2.96771356
30negative regulation of protein localization to plasma membrane (GO:1903077)2.96354782
31chondrocyte proliferation (GO:0035988)2.93887879
32endocardial cushion development (GO:0003197)2.93096479
33cardiac myofibril assembly (GO:0055003)2.89674332
34actin-myosin filament sliding (GO:0033275)2.89077066
35muscle filament sliding (GO:0030049)2.89077066
36regulation of transforming growth factor beta1 production (GO:0032908)2.88762881
37regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.88187881
38regulation of interferon-alpha production (GO:0032647)2.87703509
39neutrophil activation involved in immune response (GO:0002283)2.87001630
40negative regulation of smooth muscle cell migration (GO:0014912)2.80289885
41regulation of T cell tolerance induction (GO:0002664)2.78741905
42chondrocyte development (GO:0002063)2.77705035
43positive regulation of gamma-delta T cell activation (GO:0046645)2.76503109
44adherens junction assembly (GO:0034333)2.75977068
45cell adhesion mediated by integrin (GO:0033627)2.75866731
46regulation of interferon-beta biosynthetic process (GO:0045357)2.74264466
47blood vessel maturation (GO:0001955)2.74020545
48extracellular regulation of signal transduction (GO:1900115)2.73555521
49extracellular negative regulation of signal transduction (GO:1900116)2.73555521
50kidney mesenchyme development (GO:0072074)2.73297032
51JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.73250453
52retina vasculature morphogenesis in camera-type eye (GO:0061299)2.71530806
53cellular response to vitamin (GO:0071295)2.70621628
54actin filament-based movement (GO:0030048)2.70296027
55pericardium development (GO:0060039)2.67459391
56positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.66739374
57regulation of interleukin-12 biosynthetic process (GO:0045075)2.65501513
58collagen metabolic process (GO:0032963)2.64842557
59venous blood vessel morphogenesis (GO:0048845)2.64006366
60embryonic process involved in female pregnancy (GO:0060136)2.62006432
61import into cell (GO:0098657)2.61094051
62adhesion of symbiont to host cell (GO:0044650)2.60983877
63virion attachment to host cell (GO:0019062)2.60983877
64basement membrane organization (GO:0071711)2.60913621
65membrane raft organization (GO:0031579)2.60107230
66actin filament depolymerization (GO:0030042)2.58601037
67pyrimidine ribonucleoside catabolic process (GO:0046133)2.58203442
68regulation of integrin-mediated signaling pathway (GO:2001044)2.58041486
69negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.57846908
70actomyosin structure organization (GO:0031032)2.56389661
71myofibril assembly (GO:0030239)2.56057645
72glomerular basement membrane development (GO:0032836)2.55961798
73vascular endothelial growth factor signaling pathway (GO:0038084)2.55487195
74sprouting angiogenesis (GO:0002040)2.53869521
75negative regulation of homotypic cell-cell adhesion (GO:0034111)2.52938883
76cell migration involved in sprouting angiogenesis (GO:0002042)2.52831261
77positive regulation of macrophage differentiation (GO:0045651)2.52810075
78regulation of transforming growth factor beta2 production (GO:0032909)2.52441660
79response to epinephrine (GO:0071871)2.52437984
80regulation of the force of heart contraction (GO:0002026)2.52361107
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.51629693
82valine metabolic process (GO:0006573)2.51446745
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.50695934
84positive regulation by organism of defense response of other organism involved in symbiotic interact2.50695934
85modulation by symbiont of host immune response (GO:0052553)2.50695934
86positive regulation by symbiont of host defense response (GO:0052509)2.50695934
87modulation by symbiont of host defense response (GO:0052031)2.50695934
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.50695934
89epithelial cell-cell adhesion (GO:0090136)2.50478475
90cellular response to growth hormone stimulus (GO:0071378)2.48211227
91pathway-restricted SMAD protein phosphorylation (GO:0060389)2.45506360
92regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.43516849
93substrate adhesion-dependent cell spreading (GO:0034446)2.43310865
94multicellular organismal macromolecule metabolic process (GO:0044259)2.43284468
95collagen catabolic process (GO:0030574)2.42528480
96metanephric mesenchyme development (GO:0072075)2.41782415
97endothelial cell morphogenesis (GO:0001886)2.41059403
98cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.40649395
99hyaluronan catabolic process (GO:0030214)2.40265551
100cellular response to interferon-alpha (GO:0035457)2.39561448
101vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.38783004
102negative regulation of anoikis (GO:2000811)2.37438439
103negative regulation of skeletal muscle tissue development (GO:0048642)2.36553255
104cortical actin cytoskeleton organization (GO:0030866)2.36256661
105regulation of plasminogen activation (GO:0010755)2.35998940
106regulation of natural killer cell differentiation (GO:0032823)2.35934878
107extracellular matrix disassembly (GO:0022617)2.35269107
108positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.34707183
109positive regulation of extracellular matrix organization (GO:1903055)2.33568487
110bone trabecula formation (GO:0060346)2.33526598
111hepatocyte apoptotic process (GO:0097284)2.33489040
112multicellular organismal metabolic process (GO:0044236)2.33351315
113regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.33209000
114regulation of macrophage cytokine production (GO:0010935)2.33179775
115negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.33043515
116iron ion import (GO:0097286)2.32576492
117hypotonic response (GO:0006971)2.32198245
118negative regulation of fatty acid transport (GO:2000192)2.31854532
119cytidine deamination (GO:0009972)2.30372527
120cytidine metabolic process (GO:0046087)2.30372527
121cytidine catabolic process (GO:0006216)2.30372527
122regulation of relaxation of muscle (GO:1901077)2.26990545
123negative regulation of lipid storage (GO:0010888)2.23605289
124desmosome organization (GO:0002934)2.23000587
125detection of molecule of bacterial origin (GO:0032490)2.21684205
126oxaloacetate metabolic process (GO:0006107)2.21446435
127response to type I interferon (GO:0034340)2.19680983
128negative regulation of protein autophosphorylation (GO:0031953)2.18631090
129interferon-gamma-mediated signaling pathway (GO:0060333)2.17225605
130production of molecular mediator involved in inflammatory response (GO:0002532)2.16605608
131apoptotic cell clearance (GO:0043277)2.15611194
132cellular response to type I interferon (GO:0071357)2.13869581
133type I interferon signaling pathway (GO:0060337)2.13869581
134macrophage activation involved in immune response (GO:0002281)2.12201309
135hemidesmosome assembly (GO:0031581)2.11894190
136neutrophil activation (GO:0042119)2.10202620
137positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.09664530
138cellular response to exogenous dsRNA (GO:0071360)2.09264529
139regulation of tolerance induction (GO:0002643)2.09164942
140positive regulation of p38MAPK cascade (GO:1900745)2.08227350
141positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.07836691
142plasma membrane repair (GO:0001778)2.06813320
143tyrosine phosphorylation of STAT protein (GO:0007260)2.06648930
144regulation of sequestering of triglyceride (GO:0010889)2.06383861
145peptidyl-glutamic acid carboxylation (GO:0017187)2.05044438
146protein carboxylation (GO:0018214)2.05044438
147granulocyte activation (GO:0036230)2.04822102
148cellular response to zinc ion (GO:0071294)2.04410194
149regulation of membrane protein ectodomain proteolysis (GO:0051043)2.03536945
150establishment of endothelial barrier (GO:0061028)2.01969816
151skin morphogenesis (GO:0043589)2.01724954
152JAK-STAT cascade (GO:0007259)2.01356151
153T-helper cell differentiation (GO:0042093)2.01257837
154CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.01257837
155regulation of macrophage derived foam cell differentiation (GO:0010743)2.00571966
156positive regulation of monocyte chemotaxis (GO:0090026)2.00483828
157regulation of cholesterol storage (GO:0010885)1.99339574
158regulation of gamma-delta T cell differentiation (GO:0045586)1.98980684
159regulation of B cell receptor signaling pathway (GO:0050855)1.98758828
160positive regulation of cellular amide metabolic process (GO:0034250)1.98099577
161hydrogen peroxide biosynthetic process (GO:0050665)1.98022018
162regulation of interleukin-8 secretion (GO:2000482)1.98007170
163wound healing, spreading of epidermal cells (GO:0035313)1.97414780
164Golgi transport vesicle coating (GO:0048200)1.96841271
165COPI coating of Golgi vesicle (GO:0048205)1.96841271
166regulation of gamma-delta T cell activation (GO:0046643)1.95969448
167regulation of monocyte chemotaxis (GO:0090025)1.95511009
168fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)1.95098365
169gland morphogenesis (GO:0022612)1.94772378
170positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.94439237
171positive regulation of mitochondrial calcium ion concentration (GO:0051561)1.94320406
172positive regulation of interleukin-12 production (GO:0032735)1.93867205
173response to immune response of other organism involved in symbiotic interaction (GO:0052564)1.92314957
174response to host immune response (GO:0052572)1.92314957
175response to interleukin-15 (GO:0070672)1.91870156
176negative regulation of granulocyte differentiation (GO:0030853)1.91244199
177positive regulation of macrophage cytokine production (GO:0060907)1.91229619
178detection of external biotic stimulus (GO:0098581)1.90588118
179response to laminar fluid shear stress (GO:0034616)1.90235574
180positive regulation of fatty acid beta-oxidation (GO:0032000)1.89877469
181substrate-dependent cell migration (GO:0006929)1.89806371
182surfactant homeostasis (GO:0043129)1.88949384
183Arp2/3 complex-mediated actin nucleation (GO:0034314)1.88442905
184regulation of syncytium formation by plasma membrane fusion (GO:0060142)1.88295641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.56285567
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.52202668
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.35605481
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83862178
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.75671498
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70339486
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.65783492
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.64699182
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.59444657
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.47321065
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.44130052
12TRIM28_21343339_ChIP-Seq_HEK293_Human2.42849489
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32895963
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.30692004
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.30269109
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.29196065
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.28447823
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.27146148
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.20772350
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19853570
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.16114113
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13242785
23GATA2_21666600_ChIP-Seq_HMVEC_Human2.01184077
24* RUNX_20019798_ChIP-Seq_JUKART_Human1.99806213
25* RXR_22158963_ChIP-Seq_LIVER_Mouse1.97718172
26CLOCK_20551151_ChIP-Seq_293T_Human1.97598470
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.91995565
28GATA1_22025678_ChIP-Seq_K562_Human1.90550528
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83426099
30* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81820959
31CJUN_26792858_Chip-Seq_BT549_Human1.81820643
32FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81088398
33* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.80039980
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.73081529
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72049887
36* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67405804
37* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67405804
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.67199086
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.66137053
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.65816976
41SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64269405
42SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64269405
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.62396972
44* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.60904009
45SOX2_20726797_ChIP-Seq_SW620_Human1.58082587
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.56399444
47PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55827593
48* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55491668
49TP53_16413492_ChIP-PET_HCT116_Human1.53066515
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49400953
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.48490666
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.47159426
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45956759
54* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43870165
55VDR_24787735_ChIP-Seq_THP-1_Human1.42234555
56* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.40771238
57* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40181394
58MYB_26560356_Chip-Seq_TH2_Human1.39041933
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.36362147
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33482138
61NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32366905
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31278316
63FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.30506705
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28836586
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26421405
66EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25315672
67* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.24917811
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.24383508
69* ELK3_25401928_ChIP-Seq_HUVEC_Human1.24351163
70MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.24079623
71PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.21716835
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21674725
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20084995
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20027058
75* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19228469
76* PU_27001747_Chip-Seq_BMDM_Mouse1.18675676
77* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18113631
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17656442
79* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16205716
80CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15468160
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.14714766
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13145508
83AHR_22903824_ChIP-Seq_MCF-7_Human1.12375052
84BRD4_25478319_ChIP-Seq_HGPS_Human1.09526917
85* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08951155
86* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08366309
87SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08281134
88FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07795004
89* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05175423
90* MYB_26560356_Chip-Seq_TH1_Human1.04641816
91GATA3_27048872_Chip-Seq_THYMUS_Human1.04552972
92TP53_18474530_ChIP-ChIP_U2OS_Human1.04335444
93* TBX20_22328084_ChIP-Seq_HEART_Mouse1.04265699
94* TBX20_22080862_ChIP-Seq_HEART_Mouse1.04265699
95* TP63_23658742_ChIP-Seq_EP156T_Human1.04245631
96ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02415493
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02309257
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01308388
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00188547
100RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99995457
101NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99055264
102* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98594552
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98384772
104GATA1_19941826_ChIP-Seq_K562_Human0.98122400
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96540415
106* MAF_26560356_Chip-Seq_TH1_Human0.96160456
107PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96103690
108* GATA2_19941826_ChIP-Seq_K562_Human0.93948140
109TCF4_18268006_ChIP-ChIP_LS174T_Human0.93383295
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.92830524
111* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92783301
112ARNT_22903824_ChIP-Seq_MCF-7_Human0.92664888
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92578729
114GATA3_26560356_Chip-Seq_TH2_Human0.92218353
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.90266208
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90156634
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89874873
118* GATA4_25053715_ChIP-Seq_YYC3_Human0.89821624
119PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89253567
120EGR1_19032775_ChIP-ChIP_M12_Human0.88382240
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87063209
122* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86822072
123NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85991781
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85417555
125* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85168738
126UBF1/2_26484160_Chip-Seq_HMECs_Human0.84543566
127P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84495843
128SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.84480154
129* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84427325
130TP53_23651856_ChIP-Seq_MEFs_Mouse0.83351301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.14588081
2MP0005275_abnormal_skin_tensile2.71683474
3MP0001835_abnormal_antigen_presentation2.57395767
4MP0009384_cardiac_valve_regurgitation2.56147560
5MP0003300_gastrointestinal_ulcer2.41513956
6MP0003950_abnormal_plasma_membrane2.40008806
7MP0002166_altered_tumor_susceptibility2.18564942
8MP0000751_myopathy2.17725893
9MP0005623_abnormal_meninges_morphology2.05826224
10MP0003436_decreased_susceptibility_to2.04872782
11MP0003705_abnormal_hypodermis_morpholog2.03311965
12MP0003724_increased_susceptibility_to1.95542537
13MP0003566_abnormal_cell_adhesion1.93500642
14MP0002877_abnormal_melanocyte_morpholog1.93392849
15MP0002148_abnormal_hypersensitivity_rea1.87976666
16MP0001790_abnormal_immune_system1.83982674
17MP0005387_immune_system_phenotype1.83982674
18MP0002006_tumorigenesis1.82868173
19MP0009785_altered_susceptibility_to1.76098846
20MP0004947_skin_inflammation1.75232124
21MP0003279_aneurysm1.70614300
22MP0002060_abnormal_skin_morphology1.70028164
23MP0005000_abnormal_immune_tolerance1.68126831
24MP0000013_abnormal_adipose_tissue1.66966202
25MP0002419_abnormal_innate_immunity1.65470810
26MP0010234_abnormal_vibrissa_follicle1.62500921
27MP0005671_abnormal_response_to1.56359656
28MP0006082_CNS_inflammation1.55983808
29MP0002138_abnormal_hepatobiliary_system1.55274870
30MP0000685_abnormal_immune_system1.53955463
31MP0003191_abnormal_cellular_cholesterol1.53509857
32MP0001958_emphysema1.52800400
33MP0002009_preneoplasia1.52325464
34MP0001533_abnormal_skeleton_physiology1.51355145
35MP0006054_spinal_hemorrhage1.48587849
36MP0001800_abnormal_humoral_immune1.47040171
37MP0002452_abnormal_antigen_presenting1.46450920
38MP0002254_reproductive_system_inflammat1.45796599
39MP0005058_abnormal_lysosome_morphology1.44992464
40MP0004130_abnormal_muscle_cell1.43813480
41MP0005257_abnormal_intraocular_pressure1.42817272
42MP0002295_abnormal_pulmonary_circulatio1.42523412
43MP0002998_abnormal_bone_remodeling1.41007821
44MP0003941_abnormal_skin_development1.40209678
45MP0005025_abnormal_response_to1.39313670
46MP0009764_decreased_sensitivity_to1.39238035
47MP0009780_abnormal_chondrocyte_physiolo1.38466542
48MP0003828_pulmonary_edema1.35841053
49MP0002139_abnormal_hepatobiliary_system1.33904163
50MP0000759_abnormal_skeletal_muscle1.33487866
51MP0002723_abnormal_immune_serum1.32334414
52MP0003303_peritoneal_inflammation1.32003052
53MP0005023_abnormal_wound_healing1.29331437
54MP0002108_abnormal_muscle_morphology1.28560886
55MP0003252_abnormal_bile_duct1.27278511
56MP0005503_abnormal_tendon_morphology1.25608754
57MP0005330_cardiomyopathy1.25348891
58MP0003045_fibrosis1.25172374
59MP0006138_congestive_heart_failure1.25027714
60MP0001845_abnormal_inflammatory_respons1.23069795
61MP0002933_joint_inflammation1.21318303
62MP0001819_abnormal_immune_cell1.19523196
63MP0000343_altered_response_to1.19112434
64MP0000733_abnormal_muscle_development1.19050300
65MP0005464_abnormal_platelet_physiology1.18838263
66MP0000749_muscle_degeneration1.18717414
67MP0002420_abnormal_adaptive_immunity1.18540508
68MP0004510_myositis1.17989832
69MP0010352_gastrointestinal_tract_polyps1.17602594
70MP0010368_abnormal_lymphatic_system1.15601985
71MP0005165_increased_susceptibility_to1.15265356
72MP0005620_abnormal_muscle_contractility1.13479187
73MP0008004_abnormal_stomach_pH1.13385223
74MP0005508_abnormal_skeleton_morphology1.13132148
75MP0005164_abnormal_response_to1.12754370
76MP0010155_abnormal_intestine_physiology1.11313285
77MP0008875_abnormal_xenobiotic_pharmacok1.11170906
78MP0001853_heart_inflammation1.11163721
79MP0002405_respiratory_system_inflammati1.11016456
80MP0000003_abnormal_adipose_tissue1.09504266
81MP0003453_abnormal_keratinocyte_physiol1.08691493
82MP0001879_abnormal_lymphatic_vessel1.08234936
83MP0001348_abnormal_lacrimal_gland1.06540839
84MP0003195_calcinosis1.06455687
85MP0005595_abnormal_vascular_smooth1.05899304
86MP0005085_abnormal_gallbladder_physiolo1.05882583
87MP0003091_abnormal_cell_migration1.03654991
88MP0008469_abnormal_protein_level1.03409059
89MP0003763_abnormal_thymus_physiology1.02660596
90MP0000858_altered_metastatic_potential1.02165451
91MP0005388_respiratory_system_phenotype1.01934254
92MP0002133_abnormal_respiratory_system1.01934254
93MP0001881_abnormal_mammary_gland1.00892718
94MP0004782_abnormal_surfactant_physiolog0.98868090
95MP0002128_abnormal_blood_circulation0.98555627
96MP0004484_altered_response_of0.98528024
97MP0002796_impaired_skin_barrier0.97466679
98MP0002269_muscular_atrophy0.97104570
99MP0003448_altered_tumor_morphology0.96699319
100MP0004215_abnormal_myocardial_fiber0.96653353
101MP0001243_abnormal_dermal_layer0.95472340
102MP0005166_decreased_susceptibility_to0.93188246
103MP0001299_abnormal_eye_distance/0.92780583
104MP0005390_skeleton_phenotype0.92147115
105MP0004134_abnormal_chest_morphology0.91894065
106MP0004233_abnormal_muscle_weight0.90642201
107MP0010630_abnormal_cardiac_muscle0.90291881
108MP0001542_abnormal_bone_strength0.89994277
109MP0002332_abnormal_exercise_endurance0.89775361
110MP0000249_abnormal_blood_vessel0.89619116
111MP0005365_abnormal_bile_salt0.88801163
112MP0005385_cardiovascular_system_phenoty0.88547009
113MP0001544_abnormal_cardiovascular_syste0.88547009
114MP0009643_abnormal_urine_homeostasis0.87989498
115MP0004036_abnormal_muscle_relaxation0.87828797
116MP0005375_adipose_tissue_phenotype0.87653695
117MP0003795_abnormal_bone_structure0.87185008
118MP0002972_abnormal_cardiac_muscle0.86432876
119MP0002168_other_aberrant_phenotype0.85908670
120MP0000747_muscle_weakness0.85807264
121MP0004185_abnormal_adipocyte_glucose0.85059687
122MP0004084_abnormal_cardiac_muscle0.83945569
123MP0000767_abnormal_smooth_muscle0.83216389
124MP0005408_hypopigmentation0.83074874
125MP0002136_abnormal_kidney_physiology0.83068361
126MP0003186_abnormal_redox_activity0.82392886
127MP0001216_abnormal_epidermal_layer0.82008647
128MP0001851_eye_inflammation0.81823486
129MP0000716_abnormal_immune_system0.80813540
130MP0005083_abnormal_biliary_tract0.80340271
131MP0004883_abnormal_blood_vessel0.80215841
132MP0005171_absent_coat_pigmentation0.79921774
133MP0002896_abnormal_bone_mineralization0.79889083
134MP0008775_abnormal_heart_ventricle0.78974522
135MP0000609_abnormal_liver_physiology0.78884381
136MP0009250_abnormal_appendicular_skeleto0.78747092
137MP0000627_abnormal_mammary_gland0.77239618
138MP0005409_darkened_coat_color0.76707068
139MP0004087_abnormal_muscle_fiber0.76412541
140MP0002928_abnormal_bile_duct0.76366956
141MP0004272_abnormal_basement_membrane0.75853954
142MP0001661_extended_life_span0.75243432
143MP0000750_abnormal_muscle_regeneration0.74740988
144MP0005451_abnormal_body_composition0.72796522
145MP0005369_muscle_phenotype0.72181783
146MP0000569_abnormal_digit_pigmentation0.70956643
147MP0001614_abnormal_blood_vessel0.70846120
148MP0005666_abnormal_adipose_tissue0.68293704
149MP0000534_abnormal_ureter_morphology0.68143828
150MP0003221_abnormal_cardiomyocyte_apopto0.66860136
151MP0002837_dystrophic_cardiac_calcinosis0.66166578
152MP0002106_abnormal_muscle_physiology0.64633828
153MP0004858_abnormal_nervous_system0.64630292
154MP0010386_abnormal_urinary_bladder0.64529805

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.51468431
2Soft skin (HP:0000977)3.40965026
3Myocardial infarction (HP:0001658)3.31640412
4Ankle contracture (HP:0006466)3.23791688
5Wormian bones (HP:0002645)3.23079911
6Osteolytic defects of the hand bones (HP:0009699)3.07049715
7Osteolytic defects of the phalanges of the hand (HP:0009771)3.07049715
8Systemic lupus erythematosus (HP:0002725)3.04971861
9Spinal rigidity (HP:0003306)2.99887781
10Increased variability in muscle fiber diameter (HP:0003557)2.96260422
11Right ventricular cardiomyopathy (HP:0011663)2.94391414
12Increased connective tissue (HP:0009025)2.90661797
13Cervical subluxation (HP:0003308)2.90047061
14Bladder diverticulum (HP:0000015)2.87059265
15Overgrowth (HP:0001548)2.85914064
16Hyporeflexia of lower limbs (HP:0002600)2.79912455
17Follicular hyperkeratosis (HP:0007502)2.79739014
18Genu recurvatum (HP:0002816)2.76580536
19Abnormality of skeletal muscle fiber size (HP:0012084)2.76392411
20Exercise-induced muscle cramps (HP:0003710)2.74924151
21Aortic aneurysm (HP:0004942)2.71677850
22Aneurysm (HP:0002617)2.66592829
23Aortic regurgitation (HP:0001659)2.65220315
24Hematochezia (HP:0002573)2.64061678
25Mildly elevated creatine phosphokinase (HP:0008180)2.61890187
26Round ear (HP:0100830)2.61185115
27Blue sclerae (HP:0000592)2.58381851
28Distal lower limb muscle weakness (HP:0009053)2.55674768
29Mitral regurgitation (HP:0001653)2.53907277
30Recurrent abscess formation (HP:0002722)2.53522620
31Vertebral compression fractures (HP:0002953)2.53423521
32Aortic dissection (HP:0002647)2.52555305
33Lipoatrophy (HP:0100578)2.50943843
34Mitral stenosis (HP:0001718)2.48191274
35Ventricular tachycardia (HP:0004756)2.47803741
36Myositis (HP:0100614)2.47213668
37Interstitial pulmonary disease (HP:0006530)2.46688960
38Axonal loss (HP:0003447)2.41407724
39Protrusio acetabuli (HP:0003179)2.40534781
40Recurrent gram-negative bacterial infections (HP:0005420)2.40116314
41Vacuolated lymphocytes (HP:0001922)2.40114731
42Shallow orbits (HP:0000586)2.35295005
43Premature rupture of membranes (HP:0001788)2.33018942
44Recurrent bacterial skin infections (HP:0005406)2.32382345
45Muscle fiber splitting (HP:0003555)2.31108848
46Complement deficiency (HP:0004431)2.30560724
47Distal arthrogryposis (HP:0005684)2.27754833
48Slender build (HP:0001533)2.26955953
49Neonatal short-limb short stature (HP:0008921)2.26882130
50Distal lower limb amyotrophy (HP:0008944)2.26441470
51Hypoplasia of the iris (HP:0007676)2.24785352
52Orchitis (HP:0100796)2.24610895
53Arterial thrombosis (HP:0004420)2.24567149
54Elbow flexion contracture (HP:0002987)2.22684126
55Abnormality of dentin (HP:0010299)2.22183559
56Facial diplegia (HP:0001349)2.21970738
57Hyperextensible skin (HP:0000974)2.21887465
58Joint laxity (HP:0001388)2.20304565
59Abnormality of the acetabulum (HP:0003170)2.18735572
60Peritonitis (HP:0002586)2.15391998
61Bundle branch block (HP:0011710)2.15234371
62Abnormality of complement system (HP:0005339)2.14196532
63Autoimmune thrombocytopenia (HP:0001973)2.13525352
64Sudden death (HP:0001699)2.12823109
65Cerebral aneurysm (HP:0004944)2.11981570
66Thin bony cortex (HP:0002753)2.11650789
67Absent frontal sinuses (HP:0002688)2.10440577
68Persistence of primary teeth (HP:0006335)2.09888858
69Reduced subcutaneous adipose tissue (HP:0003758)2.09638443
70Joint stiffness (HP:0001387)2.08845963
71Syringomyelia (HP:0003396)2.08637795
72Spinal cord lesions (HP:0100561)2.08637795
73Subacute progressive viral hepatitis (HP:0006572)2.06637838
74Retrobulbar optic neuritis (HP:0100654)2.06632464
75Optic neuritis (HP:0100653)2.06632464
76Atrophic scars (HP:0001075)2.06452955
77Conjunctival hamartoma (HP:0100780)2.05268518
78Type 1 muscle fiber predominance (HP:0003803)2.05167578
79Nephritis (HP:0000123)2.04574630
80Vasculitis (HP:0002633)2.03907449
81Xanthomatosis (HP:0000991)2.03586155
82Aortic valve stenosis (HP:0001650)2.03069691
83Ovoid vertebral bodies (HP:0003300)2.03065585
84Lip pit (HP:0100267)2.02752253
85Asymmetric septal hypertrophy (HP:0001670)2.02604752
86Broad ribs (HP:0000885)2.01464427
87Esophageal varix (HP:0002040)2.01291550
88Striae distensae (HP:0001065)2.01062090
89Abnormality of the calf musculature (HP:0001430)1.99761506
90Osteomyelitis (HP:0002754)1.99689067
91Elevated erythrocyte sedimentation rate (HP:0003565)1.99242801
92Abnormal delivery (HP:0001787)1.97853296
93Bowel diverticulosis (HP:0005222)1.97004977
94Alopecia of scalp (HP:0002293)1.96639288
95Neck muscle weakness (HP:0000467)1.96346727
96Periodontitis (HP:0000704)1.95751200
97Glomerulonephritis (HP:0000099)1.95713549
98Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.95076207
99Abnormality of the common coagulation pathway (HP:0010990)1.94998992
100Muscle fiber inclusion bodies (HP:0100299)1.94527577
101Mesomelia (HP:0003027)1.93493085
102Spondylolisthesis (HP:0003302)1.92725270
103Atrial fibrillation (HP:0005110)1.90905245
104Biconcave vertebral bodies (HP:0004586)1.90723137
105Scapular winging (HP:0003691)1.89254104
106Cardiovascular calcification (HP:0011915)1.89218582
107Dilatation of the ascending aorta (HP:0005111)1.88840927
108Hypoglycemic coma (HP:0001325)1.88239346
109Tetraparesis (HP:0002273)1.88153683
110Thick nail (HP:0001805)1.87732716
111Hydroxyprolinuria (HP:0003080)1.87221360
112Abnormality of proline metabolism (HP:0010907)1.87221360
113Hypothermia (HP:0002045)1.86859824
114Spontaneous hematomas (HP:0007420)1.83484930
115Recurrent fungal infections (HP:0002841)1.82756299
116Delayed closure of the anterior fontanelle (HP:0001476)1.81626856
117Disproportionate tall stature (HP:0001519)1.81405567
118Ulnar claw (HP:0001178)1.80316610
119Gingival bleeding (HP:0000225)1.80271372
120Gastrointestinal infarctions (HP:0005244)1.79327485
121EMG: myopathic abnormalities (HP:0003458)1.78964733
122Ectopia lentis (HP:0001083)1.78158512
123Wide anterior fontanel (HP:0000260)1.77742295
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.77091339
125Abnormality of macrophages (HP:0004311)1.76648058
126Nemaline bodies (HP:0003798)1.76460093
127Ulnar bowing (HP:0003031)1.75986763
128Epidermoid cyst (HP:0200040)1.75263279
129Arterial tortuosity (HP:0005116)1.75182818
130Vascular tortuosity (HP:0004948)1.75035551
131Wrist flexion contracture (HP:0001239)1.74597925
132Camptodactyly of toe (HP:0001836)1.74597623
133Flared iliac wings (HP:0002869)1.74196706
134Increased mean platelet volume (HP:0011877)1.73741808
135Lower limb amyotrophy (HP:0007210)1.73604091
136Myoglobinuria (HP:0002913)1.72158793
137Knee flexion contracture (HP:0006380)1.71688889
138Cellulitis (HP:0100658)1.71598823
139Bradycardia (HP:0001662)1.71581438
140Recurrent bronchitis (HP:0002837)1.71015698
141Absent phalangeal crease (HP:0006109)1.70420724
142Relative macrocephaly (HP:0004482)1.69375695
143Joint hemorrhage (HP:0005261)1.69092549
144Exercise-induced myalgia (HP:0003738)1.69070962
145Increased CSF protein (HP:0002922)1.68237826
146Fragile skin (HP:0001030)1.68062079
147Broad metatarsal (HP:0001783)1.67668966
148Bone cyst (HP:0012062)1.67308956
149Abnormality of skull ossification (HP:0002703)1.67172322
150Short nail (HP:0001799)1.66619141
151Mucosal telangiectasiae (HP:0100579)1.65651637
152Segmental peripheral demyelination/remyelination (HP:0003481)1.65491960
153Acanthosis nigricans (HP:0000956)1.65362188
154Pustule (HP:0200039)1.65042018
155Venous abnormality (HP:0002624)1.64536602
156Palpitations (HP:0001962)1.64458358
157Increased IgE level (HP:0003212)1.64242305
158Abnormality of T cell number (HP:0011839)1.63745922
159Frequent falls (HP:0002359)1.63551246
160Chronic diarrhea (HP:0002028)1.63472219
161Ulnar deviation of the wrist (HP:0003049)1.63412429
162Vascular calcification (HP:0004934)1.63357033
163Dysostosis multiplex (HP:0000943)1.62743205
164Mitral valve prolapse (HP:0001634)1.62655730
165Gastrointestinal stroma tumor (HP:0100723)1.61216054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.16197309
2DDR22.67667321
3TGFBR22.66157704
4JAK32.38771965
5TTN2.35886996
6FRK2.14247081
7JAK12.06876258
8TRPM72.04341632
9TYK22.02100431
10FGFR31.93896388
11MST41.93336697
12FGFR41.91926681
13TXK1.91415158
14TBK11.90389464
15TRIB31.80280731
16MAP4K11.80196386
17PAK21.73685860
18EPHA31.69776342
19PTK21.67071904
20ERN11.61836317
21PRPF4B1.59562319
22STK381.55967724
23MAP3K61.52420265
24SIK31.50808206
25CDC42BPA1.48590003
26AKT31.47017190
27SCYL21.45627017
28IRAK31.45078260
29LATS11.44480983
30IKBKE1.42717109
31STK101.42592896
32LATS21.40198083
33ITK1.39514161
34SIK11.39315708
35PKN21.31509613
36LRRK21.30952222
37ZAP701.29934710
38MAP3K31.26403689
39* NEK91.25864534
40MAP2K31.25721083
41PRKD21.21758644
42IKBKB1.21029394
43TEC1.19759022
44MAPKAPK31.17588498
45KSR21.17566751
46MST1R1.17353624
47FER1.13256047
48IRAK41.13145308
49PIK3CA1.12230850
50RIPK11.10869222
51PIK3CG1.10502122
52CHUK1.10398990
53EPHB11.09730983
54MOS1.09202703
55STK241.08952496
56BLK1.06288853
57SGK31.05680002
58MET1.02929364
59PDK21.01328928
60JAK21.00930730
61PAK41.00232900
62KIT0.99957483
63ERBB30.99658910
64ICK0.98516034
65CSK0.98447118
66OBSCN0.96014194
67SGK20.95926110
68MAPK70.94545478
69TAOK30.92261285
70ZAK0.91196692
71PTK60.89851579
72MARK30.89154276
73STK30.89055151
74FLT30.88093173
75WNK10.86387072
76PRKCH0.86352540
77BMPR20.86304377
78ROCK10.85071130
79NLK0.84920944
80PIM20.84015897
81MYLK0.82351919
82NTRK10.80756172
83MAP3K20.80696034
84GRK70.80398768
85NUAK10.79950968
86MELK0.79857974
87MAPK150.78174563
88RPS6KA20.77997110
89PAK30.76517525
90LMTK20.76063463
91CDK60.75449543
92DMPK0.75230373
93MAPK120.74953723
94ROCK20.73570928
95MAP3K130.69494822
96ILK0.69490766
97RPS6KA40.68144225
98PRKCQ0.66636805
99PDGFRA0.66441792
100PRKG20.65898004
101LCK0.65300709
102FGFR20.64299270
103MTOR0.64015424
104CSF1R0.63838756
105MAP3K120.63747290
106MAP3K50.63026800
107HCK0.62691338
108ERBB40.61915800
109WNK40.61576223
110LIMK10.61450549
111IGF1R0.60171433
112TIE10.60117114
113RAF10.58743938
114PTK2B0.58557777
115DAPK30.57642982
116CAMK1D0.55662277
117PDGFRB0.55399767
118SYK0.53948932
119MAP2K10.53554545
120IRAK10.53100270
121MAPKAPK20.52811629
122HIPK20.52205747
123EEF2K0.52136499
124PIM10.51093318
125BTK0.51057252
126TAOK20.49829408
127MARK20.49751628
128MAP3K10.49496611
129MAP3K70.49298469
130RET0.48668641
131PDPK10.45953134
132GSK3A0.45823103
133TESK10.45697269
134EPHB20.45339026
135RPS6KC10.44230117
136RPS6KL10.44230117
137MAPK110.43929401
138PRKAA20.42435671
139INSRR0.41919517
140MAPK40.40901880
141STK40.40416046
142PRKD10.40121926
143STK38L0.39486355

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.16637856
2Caffeine metabolism_Homo sapiens_hsa002322.07478097
3Leishmaniasis_Homo sapiens_hsa051402.06748941
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.03873913
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83455088
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68808617
7Osteoclast differentiation_Homo sapiens_hsa043801.63199469
8Toxoplasmosis_Homo sapiens_hsa051451.57853526
9NF-kappa B signaling pathway_Homo sapiens_hsa040641.53438772
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.53422813
11Fatty acid degradation_Homo sapiens_hsa000711.52959261
12Malaria_Homo sapiens_hsa051441.51353625
13Measles_Homo sapiens_hsa051621.46849776
14Complement and coagulation cascades_Homo sapiens_hsa046101.46223646
15Legionellosis_Homo sapiens_hsa051341.46049856
16Pertussis_Homo sapiens_hsa051331.45961546
17Graft-versus-host disease_Homo sapiens_hsa053321.41852432
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.35536953
19TNF signaling pathway_Homo sapiens_hsa046681.31836231
20Viral myocarditis_Homo sapiens_hsa054161.29898670
21Tuberculosis_Homo sapiens_hsa051521.28779282
22Allograft rejection_Homo sapiens_hsa053301.28456488
23Renal cell carcinoma_Homo sapiens_hsa052111.24275534
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.21941104
25Rheumatoid arthritis_Homo sapiens_hsa053231.19758273
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19365549
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19095437
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.18903993
29Nitrogen metabolism_Homo sapiens_hsa009101.17151683
30Lysosome_Homo sapiens_hsa041421.16648631
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.16272148
32Hematopoietic cell lineage_Homo sapiens_hsa046401.15814526
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.14433553
34Protein digestion and absorption_Homo sapiens_hsa049741.12971009
35Antigen processing and presentation_Homo sapiens_hsa046121.12447835
36Bladder cancer_Homo sapiens_hsa052191.12338503
37Non-small cell lung cancer_Homo sapiens_hsa052231.11869867
38Phagosome_Homo sapiens_hsa041451.08983223
39Primary immunodeficiency_Homo sapiens_hsa053401.08404587
40PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07793785
41PPAR signaling pathway_Homo sapiens_hsa033201.07272148
42B cell receptor signaling pathway_Homo sapiens_hsa046621.06598229
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06427121
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.05405756
45Endometrial cancer_Homo sapiens_hsa052131.03500624
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.03048918
47Dorso-ventral axis formation_Homo sapiens_hsa043201.02550155
48Glioma_Homo sapiens_hsa052141.02279734
49Amoebiasis_Homo sapiens_hsa051461.01343490
50Propanoate metabolism_Homo sapiens_hsa006401.01224855
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00420897
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.99616916
53Insulin resistance_Homo sapiens_hsa049310.99213143
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97876326
55MicroRNAs in cancer_Homo sapiens_hsa052060.97691779
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.97319997
57Influenza A_Homo sapiens_hsa051640.97100720
58Prolactin signaling pathway_Homo sapiens_hsa049170.96495398
59Focal adhesion_Homo sapiens_hsa045100.96137366
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.95872023
61Salmonella infection_Homo sapiens_hsa051320.94652844
62Autoimmune thyroid disease_Homo sapiens_hsa053200.94012730
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93965218
64Phenylalanine metabolism_Homo sapiens_hsa003600.93861756
65Adherens junction_Homo sapiens_hsa045200.92766133
66Fatty acid metabolism_Homo sapiens_hsa012120.92647706
67Apoptosis_Homo sapiens_hsa042100.92537807
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91493517
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91469507
70Pathways in cancer_Homo sapiens_hsa052000.91265750
71ECM-receptor interaction_Homo sapiens_hsa045120.91156789
72Starch and sucrose metabolism_Homo sapiens_hsa005000.90772926
73Tryptophan metabolism_Homo sapiens_hsa003800.89804131
74Hepatitis C_Homo sapiens_hsa051600.88498660
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.86776904
76Platelet activation_Homo sapiens_hsa046110.86354464
77Pancreatic cancer_Homo sapiens_hsa052120.85967264
78Endocytosis_Homo sapiens_hsa041440.84980912
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.84933887
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84502010
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.84467434
82GnRH signaling pathway_Homo sapiens_hsa049120.84271750
83Thyroid cancer_Homo sapiens_hsa052160.83054043
84VEGF signaling pathway_Homo sapiens_hsa043700.81905865
85mTOR signaling pathway_Homo sapiens_hsa041500.81559883
86Sulfur metabolism_Homo sapiens_hsa009200.81036809
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80816642
88Rap1 signaling pathway_Homo sapiens_hsa040150.80577691
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79986663
90TGF-beta signaling pathway_Homo sapiens_hsa043500.79213224
91Hepatitis B_Homo sapiens_hsa051610.78973586
92Prion diseases_Homo sapiens_hsa050200.78937360
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78831176
94Insulin signaling pathway_Homo sapiens_hsa049100.78616005
95Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78254000
96T cell receptor signaling pathway_Homo sapiens_hsa046600.77709634
97Gap junction_Homo sapiens_hsa045400.77523500
98Renin secretion_Homo sapiens_hsa049240.75789802
99Chemical carcinogenesis_Homo sapiens_hsa052040.75600685
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.75424256
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74808235
102Proteoglycans in cancer_Homo sapiens_hsa052050.74284656
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74032441
104Chronic myeloid leukemia_Homo sapiens_hsa052200.73975506
105Chemokine signaling pathway_Homo sapiens_hsa040620.73415099
106Peroxisome_Homo sapiens_hsa041460.71626868
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71622860
108Small cell lung cancer_Homo sapiens_hsa052220.69108903
109MAPK signaling pathway_Homo sapiens_hsa040100.68826149
110Acute myeloid leukemia_Homo sapiens_hsa052210.68718558
111Inositol phosphate metabolism_Homo sapiens_hsa005620.68631480
112Shigellosis_Homo sapiens_hsa051310.66574446
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66379068
114Arginine biosynthesis_Homo sapiens_hsa002200.66243970
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66200529
116Estrogen signaling pathway_Homo sapiens_hsa049150.65249501
117Tight junction_Homo sapiens_hsa045300.64852187
118Colorectal cancer_Homo sapiens_hsa052100.64537842
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63945052
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.62325251
121Oxytocin signaling pathway_Homo sapiens_hsa049210.62178905
122FoxO signaling pathway_Homo sapiens_hsa040680.61751055
123Choline metabolism in cancer_Homo sapiens_hsa052310.61650415
124ErbB signaling pathway_Homo sapiens_hsa040120.61024594
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60972708
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60545797
127Dilated cardiomyopathy_Homo sapiens_hsa054140.60242245
128Circadian rhythm_Homo sapiens_hsa047100.59577725
129ABC transporters_Homo sapiens_hsa020100.58829359
130Pyruvate metabolism_Homo sapiens_hsa006200.58523777
131Ras signaling pathway_Homo sapiens_hsa040140.57746358
132Other glycan degradation_Homo sapiens_hsa005110.57076396
133AMPK signaling pathway_Homo sapiens_hsa041520.56047396
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55262231
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55076796
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54188846
137Melanogenesis_Homo sapiens_hsa049160.53246190
138Tyrosine metabolism_Homo sapiens_hsa003500.52616099
139HTLV-I infection_Homo sapiens_hsa051660.52239323
140Asthma_Homo sapiens_hsa053100.52002680
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50025346
142Melanoma_Homo sapiens_hsa052180.49448216
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48654308
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48497825
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48478414
146Prostate cancer_Homo sapiens_hsa052150.47875769
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.47832711
148Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47278093

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