NEK8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.58467665
2water-soluble vitamin biosynthetic process (GO:0042364)4.20751715
3fucose catabolic process (GO:0019317)4.15246106
4L-fucose metabolic process (GO:0042354)4.15246106
5L-fucose catabolic process (GO:0042355)4.15246106
6DNA deamination (GO:0045006)3.92743221
7regulation of germinal center formation (GO:0002634)3.91032758
8response to pheromone (GO:0019236)3.89638733
9positive regulation of defense response to virus by host (GO:0002230)3.77504273
10CENP-A containing nucleosome assembly (GO:0034080)3.72207763
11telomere maintenance via semi-conservative replication (GO:0032201)3.66254098
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.60189523
13indolalkylamine metabolic process (GO:0006586)3.54849661
14sulfation (GO:0051923)3.54138098
15kynurenine metabolic process (GO:0070189)3.52234995
16chromatin remodeling at centromere (GO:0031055)3.51050139
17protein polyglutamylation (GO:0018095)3.49644542
18tryptophan catabolic process (GO:0006569)3.48930273
19indole-containing compound catabolic process (GO:0042436)3.48930273
20indolalkylamine catabolic process (GO:0046218)3.48930273
21cellular response to ATP (GO:0071318)3.36843406
22DNA replication initiation (GO:0006270)3.36492830
23preassembly of GPI anchor in ER membrane (GO:0016254)3.34735430
24DNA strand elongation involved in DNA replication (GO:0006271)3.34653168
25rRNA catabolic process (GO:0016075)3.33078862
26DNA replication-independent nucleosome assembly (GO:0006336)3.32974743
27DNA replication-independent nucleosome organization (GO:0034724)3.32974743
28DNA strand elongation (GO:0022616)3.28589681
29telomere maintenance via recombination (GO:0000722)3.28032563
30regulation of DNA endoreduplication (GO:0032875)3.27291362
31protein complex biogenesis (GO:0070271)3.25306707
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.23382332
33NADH dehydrogenase complex assembly (GO:0010257)3.23382332
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.23382332
35regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.20743633
36kinetochore organization (GO:0051383)3.20186220
37regulation of memory T cell differentiation (GO:0043380)3.16697448
38tryptophan metabolic process (GO:0006568)3.15028173
39RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14924584
40tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14924584
41telomere maintenance via telomere lengthening (GO:0010833)3.13824416
42cellular response to exogenous dsRNA (GO:0071360)3.12909335
43mitotic recombination (GO:0006312)3.11441304
44meiotic chromosome segregation (GO:0045132)3.11265152
45tRNA methylation (GO:0030488)3.09431665
46protein K6-linked ubiquitination (GO:0085020)3.09339094
47endoderm formation (GO:0001706)3.06262606
48ribosomal small subunit assembly (GO:0000028)3.05106092
49deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.99758264
50nucleotide-excision repair, DNA gap filling (GO:0006297)2.95983443
51mitochondrial respiratory chain complex assembly (GO:0033108)2.94048252
52DNA replication checkpoint (GO:0000076)2.94044065
53positive regulation of fatty acid transport (GO:2000193)2.92973383
54centriole assembly (GO:0098534)2.92727427
55mannosylation (GO:0097502)2.91686906
56positive regulation of prostaglandin secretion (GO:0032308)2.91428806
57RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.91426268
58kinetochore assembly (GO:0051382)2.90038697
59cytochrome complex assembly (GO:0017004)2.86231907
60GPI anchor metabolic process (GO:0006505)2.85889306
61histone exchange (GO:0043486)2.85699640
62adaptation of signaling pathway (GO:0023058)2.83201067
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.83126153
64regulation of defense response to virus by host (GO:0050691)2.82319384
65mitotic metaphase plate congression (GO:0007080)2.81991870
66mismatch repair (GO:0006298)2.80993089
67interferon-gamma production (GO:0032609)2.80223252
68regulation of mesoderm development (GO:2000380)2.80209945
69regulation of double-strand break repair via homologous recombination (GO:0010569)2.79981587
70negative regulation of mast cell activation (GO:0033004)2.78550781
71DNA ligation (GO:0006266)2.76482830
72respiratory chain complex IV assembly (GO:0008535)2.75903729
73somite development (GO:0061053)2.75537410
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71868268
75pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.71652767
76DNA synthesis involved in DNA repair (GO:0000731)2.69694629
77regulation of T cell mediated cytotoxicity (GO:0001914)2.68389773
78positive regulation of icosanoid secretion (GO:0032305)2.68232914
79protoporphyrinogen IX biosynthetic process (GO:0006782)2.67682712
80axoneme assembly (GO:0035082)2.67613669
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.65600981
82positive regulation of T cell differentiation in thymus (GO:0033089)2.64965711
83positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.63927917
84negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.63806403
85negative regulation of DNA-templated transcription, elongation (GO:0032785)2.63806403
86intra-S DNA damage checkpoint (GO:0031573)2.63687598
87base-excision repair, AP site formation (GO:0006285)2.63282786
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63031017
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.62148406
90detection of light stimulus involved in visual perception (GO:0050908)2.61880011
91detection of light stimulus involved in sensory perception (GO:0050962)2.61880011
92positive regulation of DNA-dependent DNA replication (GO:2000105)2.61860285
93microtubule depolymerization (GO:0007019)2.61402135
94indole-containing compound metabolic process (GO:0042430)2.60883764
95somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.60578886
96somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.60578886
97isotype switching (GO:0045190)2.60578886
98tolerance induction (GO:0002507)2.60471032
99telomere maintenance (GO:0000723)2.59128704
100purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.59016120
1013-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.59016120
102piRNA metabolic process (GO:0034587)2.58826755
103negative regulation of telomere maintenance (GO:0032205)2.58020912
104positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56081801
105gamma-aminobutyric acid transport (GO:0015812)2.55946619
106negative regulation of DNA-dependent DNA replication (GO:2000104)2.55864872
107regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.55807167
108telomere organization (GO:0032200)2.55513955
109cellular response to interferon-beta (GO:0035458)2.54790504
110nuclear pore complex assembly (GO:0051292)2.54446467
111cellular response to interleukin-15 (GO:0071350)2.54299154
112trophoblast giant cell differentiation (GO:0060707)2.54106120
113pseudouridine synthesis (GO:0001522)2.53839905
114cellular ketone body metabolic process (GO:0046950)2.53569409
115regulation of mitotic spindle checkpoint (GO:1903504)2.53283562
116regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.53283562
117cytidine metabolic process (GO:0046087)2.52808788
118cytidine catabolic process (GO:0006216)2.52808788
119cytidine deamination (GO:0009972)2.52808788
120regulation of rhodopsin mediated signaling pathway (GO:0022400)2.52598490
121amine catabolic process (GO:0009310)2.52446730
122cellular biogenic amine catabolic process (GO:0042402)2.52446730
123negative regulation by host of viral transcription (GO:0043922)2.50794497
124maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.50636672
125multicellular organism reproduction (GO:0032504)2.50080102
126nuclear pore organization (GO:0006999)2.47506022
127regulation of chromatin binding (GO:0035561)2.47463246
128positive regulation of T-helper 1 type immune response (GO:0002827)2.47409388
129protein-cofactor linkage (GO:0018065)2.47162244
130regulation of spindle organization (GO:0090224)2.46937022
131DNA strand renaturation (GO:0000733)2.46817093
132platelet dense granule organization (GO:0060155)2.45964799
133regulation of glomerulus development (GO:0090192)2.45057089
134pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.43958134
135mitotic sister chromatid segregation (GO:0000070)2.43789645
136positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.43147745
137S-adenosylmethionine metabolic process (GO:0046500)2.43144386
138regulation of gene silencing by RNA (GO:0060966)2.42609619
139regulation of posttranscriptional gene silencing (GO:0060147)2.42609619
140regulation of gene silencing by miRNA (GO:0060964)2.42609619
141deoxyribonucleotide biosynthetic process (GO:0009263)2.41309614
142transcription-coupled nucleotide-excision repair (GO:0006283)2.40958448
143DNA catabolic process, exonucleolytic (GO:0000738)2.40829726
144ATP synthesis coupled proton transport (GO:0015986)2.40244083
145energy coupled proton transport, down electrochemical gradient (GO:0015985)2.40244083
146rhodopsin mediated signaling pathway (GO:0016056)2.40241151
147L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40079594
148parturition (GO:0007567)2.38952014
149protein localization to kinetochore (GO:0034501)2.38828421
150epithelial cilium movement (GO:0003351)2.38625452
151negative regulation of chromosome segregation (GO:0051985)2.38416533
152metaphase plate congression (GO:0051310)2.38351677
153DNA damage response, detection of DNA damage (GO:0042769)2.38245551
154DNA-dependent DNA replication (GO:0006261)2.36917007
155regulation of histone H3-K9 methylation (GO:0051570)2.36829887
156termination of RNA polymerase I transcription (GO:0006363)2.36445355
157membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36353057
158somatic diversification of immunoglobulins (GO:0016445)2.35957432
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.35938463
160negative regulation of mitotic sister chromatid segregation (GO:0033048)2.35938463
161negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.35938463
162negative regulation of sister chromatid segregation (GO:0033046)2.35938463
163DNA damage response, signal transduction resulting in transcription (GO:0042772)2.35578041
164chromatin assembly or disassembly (GO:0006333)2.35371666
165response to UV-B (GO:0010224)2.34634297
166axonemal dynein complex assembly (GO:0070286)2.34488014
167positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34071042
168synaptic transmission, cholinergic (GO:0007271)2.33940705
169spindle checkpoint (GO:0031577)2.33934825
170regulation of telomere maintenance (GO:0032204)2.33412624
171protein localization to chromosome, centromeric region (GO:0071459)2.33195224
172ATP-dependent chromatin remodeling (GO:0043044)2.33178618
173positive regulation of protein homodimerization activity (GO:0090073)2.32800148
174centriole replication (GO:0007099)2.32743652
175cellular anion homeostasis (GO:0030002)2.32207495
176regulation of regulatory T cell differentiation (GO:0045589)2.31903596
177tRNA processing (GO:0008033)2.31548329
178spindle assembly checkpoint (GO:0071173)2.31395522
179somatic recombination of immunoglobulin gene segments (GO:0016447)2.31177622
180base-excision repair (GO:0006284)2.30450747
181negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.26570747
182maturation of SSU-rRNA (GO:0030490)2.26104340
183mitotic spindle assembly checkpoint (GO:0007094)2.26053765
184transcription elongation from RNA polymerase I promoter (GO:0006362)2.25762727
185mitotic nuclear envelope disassembly (GO:0007077)2.25133089
186ribosome biogenesis (GO:0042254)2.24955195
187DNA replication (GO:0006260)2.24392356
188RNA methylation (GO:0001510)2.24162247
189DNA replication-dependent nucleosome assembly (GO:0006335)2.24057541
190DNA replication-dependent nucleosome organization (GO:0034723)2.24057541
191nucleobase biosynthetic process (GO:0046112)2.23619727
192attachment of spindle microtubules to kinetochore (GO:0008608)2.21267525
193pore complex assembly (GO:0046931)2.21222381
194proteasome assembly (GO:0043248)2.20809581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human3.87508604
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.82874941
3ZNF274_21170338_ChIP-Seq_K562_Hela3.52691896
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.52305101
5EZH2_22144423_ChIP-Seq_EOC_Human3.35778789
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.22650903
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.18182677
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.01298182
9VDR_22108803_ChIP-Seq_LS180_Human2.92025990
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83451418
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.80439898
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.58762147
13IRF1_19129219_ChIP-ChIP_H3396_Human2.49169664
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36420881
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.36318433
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.28848961
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22683788
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18166114
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.12720117
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.11571382
21EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.10338718
22* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09447528
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06800762
24* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.06302456
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06119807
26EST1_17652178_ChIP-ChIP_JURKAT_Human2.05178106
27E2F7_22180533_ChIP-Seq_HELA_Human11.2334472
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94938771
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86322230
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.84485151
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84261981
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.83008675
33FOXP3_21729870_ChIP-Seq_TREG_Human1.81710599
34VDR_23849224_ChIP-Seq_CD4+_Human1.81297958
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.80029249
36AR_21909140_ChIP-Seq_LNCAP_Human1.74608076
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71965837
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71670165
39TP53_22573176_ChIP-Seq_HFKS_Human1.70792301
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70096960
41* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69218355
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.67543821
43DCP1A_22483619_ChIP-Seq_HELA_Human1.65051253
44ER_23166858_ChIP-Seq_MCF-7_Human1.61792601
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61361502
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61200506
47IGF1R_20145208_ChIP-Seq_DFB_Human1.60941743
48* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59823442
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58428277
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55043769
51EWS_26573619_Chip-Seq_HEK293_Human1.54821330
52GBX2_23144817_ChIP-Seq_PC3_Human1.54741090
53* IRF8_22096565_ChIP-ChIP_GC-B_Human1.53663097
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49907161
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49710371
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49500453
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48251039
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.48251039
59NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.46497514
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45469553
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45413326
62* ELK1_19687146_ChIP-ChIP_HELA_Human1.44409033
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44384098
64TAF15_26573619_Chip-Seq_HEK293_Human1.42759684
65NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42229955
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.40865569
67TTF2_22483619_ChIP-Seq_HELA_Human1.39089520
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.38210648
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37531207
70ERA_21632823_ChIP-Seq_H3396_Human1.37244620
71GATA3_26560356_Chip-Seq_TH2_Human1.36524111
72NANOG_20526341_ChIP-Seq_ESCs_Human1.35116274
73TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34503003
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.33152191
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31614869
76HOXB7_26014856_ChIP-Seq_BT474_Human1.31471711
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31195163
78TAF2_19829295_ChIP-Seq_ESCs_Human1.30620682
79* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30493938
80XRN2_22483619_ChIP-Seq_HELA_Human1.30233257
81NCOR_22424771_ChIP-Seq_293T_Human1.29318866
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27984923
83RUNX_20019798_ChIP-Seq_JUKART_Human1.27877462
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27370853
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27345707
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27161971
87P300_19829295_ChIP-Seq_ESCs_Human1.26230601
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.26069782
89PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25741572
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25245021
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25185396
92AR_20517297_ChIP-Seq_VCAP_Human1.24725914
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23490464
94YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23408233
95AUTS2_25519132_ChIP-Seq_293T-REX_Human1.19753923
96HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19617242
97IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17519160
98MYC_19829295_ChIP-Seq_ESCs_Human1.17119717
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.16998870
100REST_21632747_ChIP-Seq_MESCs_Mouse1.16940089
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.16096383
102TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14569247
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14557395
104CBP_20019798_ChIP-Seq_JUKART_Human1.14557395
105RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14530697
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14477388
107CIITA_25753668_ChIP-Seq_RAJI_Human1.13459582
108BCAT_22108803_ChIP-Seq_LS180_Human1.13023873
109FOXH1_21741376_ChIP-Seq_ESCs_Human1.12409956
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12167422
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11160717
112FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11001225
113POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10125778
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09909654
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08875156
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08526384
117KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07959165
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07541903
119P53_21459846_ChIP-Seq_SAOS-2_Human1.07439579
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07374794
121FOXH1_21741376_ChIP-Seq_EPCs_Human1.07273873
122NANOG_19829295_ChIP-Seq_ESCs_Human1.06654303
123SOX2_19829295_ChIP-Seq_ESCs_Human1.06654303
124CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06576469
125SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06475122
126MYB_26560356_Chip-Seq_TH2_Human1.06439692
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04112082
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03284331
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.02890189
130THAP11_20581084_ChIP-Seq_MESCs_Mouse1.02698537
131SPI1_23547873_ChIP-Seq_NB4_Human1.02290567
132FUS_26573619_Chip-Seq_HEK293_Human1.01966716
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01329044
134* MYB_26560356_Chip-Seq_TH1_Human1.01215617
135PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00628709
136* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.00585064
137OCT4_20526341_ChIP-Seq_ESCs_Human1.00583430
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.00355498
139YY1_22570637_ChIP-Seq_MALME-3M_Human1.00280969
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00270433
141TCF4_23295773_ChIP-Seq_U87_Human1.00214164
142SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00039218
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.99909733
144MYC_22102868_ChIP-Seq_BL_Human0.99749070
145CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99737290
146STAT1_20625510_ChIP-Seq_HELA_Human0.99641669
147BCL6_27268052_Chip-Seq_Bcells_Human0.99167612
148PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98793523
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97989752
150DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97946635
151CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97902681
152P300_27268052_Chip-Seq_Bcells_Human0.97025955
153GABP_19822575_ChIP-Seq_HepG2_Human0.96606252
154SCL_19346495_ChIP-Seq_HPC-7_Human0.96269228
155* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95667287
156MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95640453
157NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95562709
158LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94954216
159E2F1_20622854_ChIP-Seq_HELA_Human0.94797089
160ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94410267
161SMRT_27268052_Chip-Seq_Bcells_Human0.94191609
162* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92814176
163LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89310045
164MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86314312
165PCGF2_27294783_Chip-Seq_NPCs_Mouse0.85451436
166MAF_26560356_Chip-Seq_TH1_Human0.84492752
167NFE2_27457419_Chip-Seq_LIVER_Mouse0.83329282
168RBPJ_22232070_ChIP-Seq_NCS_Mouse0.82908248
169FLI1_27457419_Chip-Seq_LIVER_Mouse0.82086098
170HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.81695478
171* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81690135
172* RUNX1_22412390_ChIP-Seq_EML_Mouse0.77770566
173PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77643057
174STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.77619727
175MYC_18940864_ChIP-ChIP_HL60_Human0.76865955
176FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.72554304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.66486791
2MP0008057_abnormal_DNA_replication3.53501122
3MP0003693_abnormal_embryo_hatching3.49554547
4MP0003111_abnormal_nucleus_morphology3.19858424
5MP0010094_abnormal_chromosome_stability3.19292532
6MP0005646_abnormal_pituitary_gland3.18079942
7MP0003195_calcinosis2.75043584
8MP0006292_abnormal_olfactory_placode2.67739779
9MP0003077_abnormal_cell_cycle2.60550380
10MP0003646_muscle_fatigue2.56673612
11MP0002396_abnormal_hematopoietic_system2.42177024
12MP0008872_abnormal_physiological_respon2.34206545
13MP0002132_abnormal_respiratory_system2.23856163
14MP0002837_dystrophic_cardiac_calcinosis2.23716018
15MP0004885_abnormal_endolymph2.17583255
16MP0002876_abnormal_thyroid_physiology2.15111825
17MP0003763_abnormal_thymus_physiology2.14244757
18MP0005551_abnormal_eye_electrophysiolog2.12128450
19MP0003828_pulmonary_edema2.09313542
20MP0005645_abnormal_hypothalamus_physiol2.03224247
21MP0008007_abnormal_cellular_replicative1.92766755
22MP0003786_premature_aging1.92551341
23MP0001986_abnormal_taste_sensitivity1.90292879
24MP0003787_abnormal_imprinting1.90083647
25MP0008875_abnormal_xenobiotic_pharmacok1.88690097
26MP0004145_abnormal_muscle_electrophysio1.87765275
27MP0006072_abnormal_retinal_apoptosis1.87104217
28MP0000566_synostosis1.81849987
29MP0004957_abnormal_blastocyst_morpholog1.80099334
30MP0001968_abnormal_touch/_nociception1.71700552
31MP0000490_abnormal_crypts_of1.70867164
32MP0005075_abnormal_melanosome_morpholog1.66890633
33MP0001835_abnormal_antigen_presentation1.63272135
34MP0003011_delayed_dark_adaptation1.62371088
35MP0002163_abnormal_gland_morphology1.60145900
36MP0003136_yellow_coat_color1.59517524
37MP0001485_abnormal_pinna_reflex1.59257879
38MP0003718_maternal_effect1.58277192
39MP0009333_abnormal_splenocyte_physiolog1.56333327
40MP0008932_abnormal_embryonic_tissue1.54683000
41MP0001800_abnormal_humoral_immune1.52883808
42MP0004142_abnormal_muscle_tone1.51759147
43MP0000685_abnormal_immune_system1.49420241
44MP0002398_abnormal_bone_marrow1.47931129
45MP0010030_abnormal_orbit_morphology1.42067101
46MP0002405_respiratory_system_inflammati1.40452376
47MP0000372_irregular_coat_pigmentation1.39979749
48MP0003941_abnormal_skin_development1.39336092
49MP0001853_heart_inflammation1.39139806
50MP0002254_reproductive_system_inflammat1.37897676
51MP0001790_abnormal_immune_system1.35590057
52MP0005387_immune_system_phenotype1.35590057
53MP0009785_altered_susceptibility_to1.33736923
54MP0000631_abnormal_neuroendocrine_gland1.32977324
55MP0002452_abnormal_antigen_presenting1.31162385
56MP0000689_abnormal_spleen_morphology1.30723797
57MP0009745_abnormal_behavioral_response1.30345351
58MP0005671_abnormal_response_to1.29593624
59MP0001919_abnormal_reproductive_system1.28803033
60MP0004043_abnormal_pH_regulation1.28669287
61MP0002102_abnormal_ear_morphology1.28569610
62MP0000703_abnormal_thymus_morphology1.27709523
63MP0002722_abnormal_immune_system1.27155923
64MP0004808_abnormal_hematopoietic_stem1.25633021
65MP0002272_abnormal_nervous_system1.24566798
66MP0001293_anophthalmia1.23383904
67MP0002210_abnormal_sex_determination1.22560688
68MP0005253_abnormal_eye_physiology1.21988597
69MP0003283_abnormal_digestive_organ1.20313251
70MP0002420_abnormal_adaptive_immunity1.18910946
71MP0009278_abnormal_bone_marrow1.18415179
72MP0002249_abnormal_larynx_morphology1.18399866
73MP0001819_abnormal_immune_cell1.18299264
74MP0002723_abnormal_immune_serum1.17641430
75MP0001119_abnormal_female_reproductive1.17167106
76MP0000716_abnormal_immune_system1.14651232
77MP0004381_abnormal_hair_follicle1.14121685
78MP0004742_abnormal_vestibular_system1.12448678
79MP0002429_abnormal_blood_cell1.11254366
80MP0005000_abnormal_immune_tolerance1.09570550
81MP0002736_abnormal_nociception_after1.09455454
82MP0001501_abnormal_sleep_pattern1.08784165
83MP0005397_hematopoietic_system_phenotyp1.04485636
84MP0001545_abnormal_hematopoietic_system1.04485636
85MP0000350_abnormal_cell_proliferation1.03970332
86MP0002148_abnormal_hypersensitivity_rea1.03515057
87MP0005360_urolithiasis1.02853474
88MP0003724_increased_susceptibility_to1.02766611
89MP0005084_abnormal_gallbladder_morpholo1.02415049
90MP0003878_abnormal_ear_physiology1.02323440
91MP0005377_hearing/vestibular/ear_phenot1.02323440
92MP0008775_abnormal_heart_ventricle1.02259434
93MP0002938_white_spotting1.01735733
94MP0000858_altered_metastatic_potential1.01509461
95MP0005025_abnormal_response_to1.01367652
96MP0001286_abnormal_eye_development1.01050982
97MP0009046_muscle_twitch1.00656512
98MP0000313_abnormal_cell_death0.99976602
99MP0008995_early_reproductive_senescence0.99861341
100MP0002160_abnormal_reproductive_system0.99841637
101MP0005410_abnormal_fertilization0.98227452
102MP0002653_abnormal_ependyma_morphology0.97784758
103MP0002089_abnormal_postnatal_growth/wei0.96014057
104MP0002638_abnormal_pupillary_reflex0.95954941
105MP0001873_stomach_inflammation0.95070790
106MP0001765_abnormal_ion_homeostasis0.94750205
107MP0003638_abnormal_response/metabolism_0.94406382
108MP0000049_abnormal_middle_ear0.93273453
109MP0004147_increased_porphyrin_level0.92692842
110MP0003121_genomic_imprinting0.92481961
111MP0002019_abnormal_tumor_incidence0.92046057
112MP0003436_decreased_susceptibility_to0.91357556
113MP0002277_abnormal_respiratory_mucosa0.91117709
114MP0001764_abnormal_homeostasis0.88394072
115MP0008789_abnormal_olfactory_epithelium0.88262650
116MP0004133_heterotaxia0.88207758
117MP0001145_abnormal_male_reproductive0.87525453
118MP0001188_hyperpigmentation0.87361889
119MP0001905_abnormal_dopamine_level0.87166520
120MP0003119_abnormal_digestive_system0.86652224
121MP0008877_abnormal_DNA_methylation0.86371961
122MP0002928_abnormal_bile_duct0.86281627
123MP0002419_abnormal_innate_immunity0.85741894
124MP0005389_reproductive_system_phenotype0.85449299
125MP0005171_absent_coat_pigmentation0.85445935
126MP0005174_abnormal_tail_pigmentation0.84939993
127MP0008260_abnormal_autophagy0.84115422
128MP0003879_abnormal_hair_cell0.83710357
129MP0001929_abnormal_gametogenesis0.83509957
130MP0000230_abnormal_systemic_arterial0.83066404
131MP0005503_abnormal_tendon_morphology0.82986195
132MP0002933_joint_inflammation0.82132996
133MP0000026_abnormal_inner_ear0.81836066
134MP0001963_abnormal_hearing_physiology0.81529864
135MP0001486_abnormal_startle_reflex0.81356577
136MP0005310_abnormal_salivary_gland0.80718443
137MP0002693_abnormal_pancreas_physiology0.79269859
138MP0000653_abnormal_sex_gland0.78165445
139MP0000427_abnormal_hair_cycle0.77185294
140MP0002733_abnormal_thermal_nociception0.77048465
141MP0010155_abnormal_intestine_physiology0.76707159
142MP0001348_abnormal_lacrimal_gland0.75244060
143MP0002095_abnormal_skin_pigmentation0.74897685
144MP0005636_abnormal_mineral_homeostasis0.74832121
145MP0010386_abnormal_urinary_bladder0.74159314
146MP0005380_embryogenesis_phenotype0.74109533
147MP0001672_abnormal_embryogenesis/_devel0.74109533
148MP0010329_abnormal_lipoprotein_level0.73629342
149MP0009764_decreased_sensitivity_to0.72677402
150MP0009697_abnormal_copulation0.72210239
151MP0002138_abnormal_hepatobiliary_system0.71707757
152MP0005167_abnormal_blood-brain_barrier0.71605019
153* MP0002557_abnormal_social/conspecific_i0.70196097
154MP0003942_abnormal_urinary_system0.69944695
155MP0002229_neurodegeneration0.69928138
156MP0000470_abnormal_stomach_morphology0.68896599
157* MP0005332_abnormal_amino_acid0.68761235
158MP0003937_abnormal_limbs/digits/tail_de0.67975521
159MP0000371_diluted_coat_color0.67792698
160MP0004197_abnormal_fetal_growth/weight/0.67146809
161MP0005379_endocrine/exocrine_gland_phen0.65464380
162MP0002111_abnormal_tail_morphology0.64653416

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.37830775
2Chromsome breakage (HP:0040012)5.00996531
3Congenital stationary night blindness (HP:0007642)3.91348754
4Duplicated collecting system (HP:0000081)3.76484011
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.59246831
6Absent/shortened dynein arms (HP:0200106)3.59246831
7Abnormality of the renal collecting system (HP:0004742)3.38479778
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.30957659
9Abolished electroretinogram (ERG) (HP:0000550)3.27849440
10Meckel diverticulum (HP:0002245)3.27576970
11Molar tooth sign on MRI (HP:0002419)3.25285940
12Abnormality of midbrain morphology (HP:0002418)3.25285940
13Pendular nystagmus (HP:0012043)3.24015446
14Reticulocytopenia (HP:0001896)3.23296089
15Abnormality of the preputium (HP:0100587)3.14714551
16Methylmalonic acidemia (HP:0002912)3.12612524
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.11988762
18Abnormality of the ileum (HP:0001549)3.11265273
19Ectopic kidney (HP:0000086)3.10106566
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.08623294
21Abnormal ciliary motility (HP:0012262)3.07860856
22Birth length less than 3rd percentile (HP:0003561)3.06211807
23Abnormal rod and cone electroretinograms (HP:0008323)3.04287278
24Abnormal respiratory epithelium morphology (HP:0012253)2.99918775
25Abnormal respiratory motile cilium morphology (HP:0005938)2.99918775
26Attenuation of retinal blood vessels (HP:0007843)2.87714394
27Abnormality of chromosome stability (HP:0003220)2.84185150
28Upper limb muscle weakness (HP:0003484)2.72776847
29* Nephronophthisis (HP:0000090)2.72126782
30Type II lissencephaly (HP:0007260)2.71041359
31Methylmalonic aciduria (HP:0012120)2.68212690
32Duplication of thumb phalanx (HP:0009942)2.67446179
33Abnormality of DNA repair (HP:0003254)2.64997785
343-Methylglutaconic aciduria (HP:0003535)2.64219001
35Abnormality of the heme biosynthetic pathway (HP:0010472)2.61167515
36Abnormal respiratory motile cilium physiology (HP:0012261)2.60625175
37Nephroblastoma (Wilms tumor) (HP:0002667)2.59248225
38Clubbing of toes (HP:0100760)2.59107154
39Recurrent sinusitis (HP:0011108)2.56294408
40Stomach cancer (HP:0012126)2.55589638
41Osteomalacia (HP:0002749)2.53812956
42Duodenal stenosis (HP:0100867)2.50682957
43Small intestinal stenosis (HP:0012848)2.50682957
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48999770
45Abnormality of alanine metabolism (HP:0010916)2.48999770
46Hyperalaninemia (HP:0003348)2.48999770
47Stomatitis (HP:0010280)2.48658780
48Embryonal renal neoplasm (HP:0011794)2.47277685
49Decreased central vision (HP:0007663)2.44967823
50Polydipsia (HP:0001959)2.44410231
51Abnormal drinking behavior (HP:0030082)2.44410231
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43513519
53* Abnormality of the renal medulla (HP:0100957)2.39014502
54Breast hypoplasia (HP:0003187)2.38623510
55Decreased circulating renin level (HP:0003351)2.35054730
56Increased corneal curvature (HP:0100692)2.32799859
57Keratoconus (HP:0000563)2.32799859
58Absent thumb (HP:0009777)2.32609062
59* Abnormality of the renal cortex (HP:0011035)2.31044713
60Severe combined immunodeficiency (HP:0004430)2.28242963
61Impulsivity (HP:0100710)2.27700083
62Congenital, generalized hypertrichosis (HP:0004540)2.27264143
63Absent radius (HP:0003974)2.26915965
64Abnormality of the carotid arteries (HP:0005344)2.25461178
65Patellar aplasia (HP:0006443)2.25054784
66Chronic hepatic failure (HP:0100626)2.24244615
67Abnormal number of incisors (HP:0011064)2.23782686
68Cystic liver disease (HP:0006706)2.21605172
6911 pairs of ribs (HP:0000878)2.21572961
70Bone marrow hypocellularity (HP:0005528)2.18985684
71Aplasia involving forearm bones (HP:0009822)2.17955354
72Absent forearm bone (HP:0003953)2.17955354
73Agitation (HP:0000713)2.16693172
74Elevated erythrocyte sedimentation rate (HP:0003565)2.16691390
75IgM deficiency (HP:0002850)2.13774547
76Selective tooth agenesis (HP:0001592)2.13687734
77Mitochondrial inheritance (HP:0001427)2.13410866
78Thyroid-stimulating hormone excess (HP:0002925)2.13233742
79Type 2 muscle fiber atrophy (HP:0003554)2.13076315
80Aplasia/hypoplasia of the uterus (HP:0008684)2.11653699
81Abnormality of the duodenum (HP:0002246)2.10916251
82Abnormality of pyrimidine metabolism (HP:0004353)2.08394197
83Aplasia/Hypoplasia of the patella (HP:0006498)2.06380647
84Increased CSF lactate (HP:0002490)2.03388254
85Recurrent pneumonia (HP:0006532)2.03055934
86Polyuria (HP:0000103)2.02665307
87Triphalangeal thumb (HP:0001199)2.02288558
88Thyroiditis (HP:0100646)2.01296721
89Aplasia/Hypoplasia of the earlobes (HP:0009906)2.00878791
90Myelodysplasia (HP:0002863)2.00427708
91Hypoplasia of the uterus (HP:0000013)2.00365567
92Congenital hepatic fibrosis (HP:0002612)1.99410641
93Abnormality of the proximal phalanges of the hand (HP:0009834)1.98874566
94Muscle fiber atrophy (HP:0100295)1.98618345
95Sclerocornea (HP:0000647)1.98528693
96Ureteral duplication (HP:0000073)1.98493526
97Tubular atrophy (HP:0000092)1.98402073
98Medial flaring of the eyebrow (HP:0010747)1.97130193
99Pancytopenia (HP:0001876)1.97011508
100Concave nail (HP:0001598)1.94749907
101Hepatocellular necrosis (HP:0001404)1.94239294
102Prostate neoplasm (HP:0100787)1.93293847
103Abnormality of B cell number (HP:0010975)1.92206072
104Inability to walk (HP:0002540)1.90293169
105Bile duct proliferation (HP:0001408)1.90109915
106Abnormal biliary tract physiology (HP:0012439)1.90109915
107Sloping forehead (HP:0000340)1.89592059
108Hypoplasia of the fovea (HP:0007750)1.87215656
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.87215656
110Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.85858956
111Retrobulbar optic neuritis (HP:0100654)1.83526704
112Optic neuritis (HP:0100653)1.83526704
113Bilateral microphthalmos (HP:0007633)1.82979563
114IgG deficiency (HP:0004315)1.82066028
115Abnormality of the incisor (HP:0000676)1.81922670
116Abnormal lung lobation (HP:0002101)1.81762549
117Abnormality of the nasal septum (HP:0000419)1.81660703
118Acute necrotizing encephalopathy (HP:0006965)1.81052787
119Ketosis (HP:0001946)1.81019887
120Genetic anticipation (HP:0003743)1.80667300
121Gaze-evoked nystagmus (HP:0000640)1.80491822
122Short thumb (HP:0009778)1.80144285
123True hermaphroditism (HP:0010459)1.79837006
124Median cleft lip (HP:0000161)1.79675610
125Furrowed tongue (HP:0000221)1.79062946
126Bony spicule pigmentary retinopathy (HP:0007737)1.78974065
127Hepatic necrosis (HP:0002605)1.78042737
128Aplasia/Hypoplasia of the tibia (HP:0005772)1.77883302
129Abnormality of vitamin B metabolism (HP:0004340)1.77334951
130Clumsiness (HP:0002312)1.75841905
131Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.75293803
132Congenital sensorineural hearing impairment (HP:0008527)1.75037701
133Male pseudohermaphroditism (HP:0000037)1.74819651
134Conical tooth (HP:0000698)1.74370033
135Severe visual impairment (HP:0001141)1.74130787
136Hyperglycinemia (HP:0002154)1.73558636
137Progressive inability to walk (HP:0002505)1.72621678
138Supernumerary spleens (HP:0009799)1.71968970
139Abnormality of the pons (HP:0007361)1.71349328
140Large for gestational age (HP:0001520)1.70735181
141Aplasia/Hypoplasia of the sternum (HP:0006714)1.70612445
142Abnormality of the middle phalanges of the toes (HP:0010183)1.70063655
143Lipid accumulation in hepatocytes (HP:0006561)1.69999522
144Recurrent lower respiratory tract infections (HP:0002783)1.69855625
145Anencephaly (HP:0002323)1.69354368
146Preaxial hand polydactyly (HP:0001177)1.69159357
147Facial cleft (HP:0002006)1.69131505
148Increased serum lactate (HP:0002151)1.68638632
149Abnormality of the vitamin B12 metabolism (HP:0004341)1.68515111
150Petechiae (HP:0000967)1.68085547
151Hypoplasia of the pons (HP:0012110)1.68074762
152* Aplasia/Hypoplasia of the spleen (HP:0010451)1.67997367
153Optic disc pallor (HP:0000543)1.67958746
154Abnormality of the phalanges of the 5th finger (HP:0004213)1.67326565
155Progressive cerebellar ataxia (HP:0002073)1.67145294
156Increased nuchal translucency (HP:0010880)1.66837632
157Leukopenia (HP:0001882)1.66689834
158Optic nerve coloboma (HP:0000588)1.66222334
159Postaxial foot polydactyly (HP:0001830)1.65457125
160Mediastinal lymphadenopathy (HP:0100721)1.65167532
161Chronic sinusitis (HP:0011109)1.64982413
162Embryonal neoplasm (HP:0002898)1.63597150
163IgA deficiency (HP:0002720)1.63230805
164Recurrent bronchitis (HP:0002837)1.62461292
165Onycholysis (HP:0001806)1.61808597
166Hypochromic anemia (HP:0001931)1.59668532
167Pancreatic cysts (HP:0001737)1.56952720
168Bronchiectasis (HP:0002110)1.56217674
169Tracheoesophageal fistula (HP:0002575)1.56049127
170Pancreatic fibrosis (HP:0100732)1.54830058
171Occipital encephalocele (HP:0002085)1.54671696
172Lymphoma (HP:0002665)1.54229613
173Natal tooth (HP:0000695)1.53461331
174Volvulus (HP:0002580)1.53290563
175Dry hair (HP:0011359)1.52966895
176Abnormal number of erythroid precursors (HP:0012131)1.51310007
177Aplastic anemia (HP:0001915)1.51260794
178Short middle phalanx of the 5th finger (HP:0004220)1.51066337
179Increased IgM level (HP:0003496)1.50874586
180Prolonged bleeding time (HP:0003010)1.50258052
181Horseshoe kidney (HP:0000085)1.49285993
182Hypergonadotropic hypogonadism (HP:0000815)1.47950765
183Abnormality of T cells (HP:0002843)1.46074840
184Type I transferrin isoform profile (HP:0003642)1.45717717
185Abnormality of molar morphology (HP:0011070)1.45544600
186Abnormality of molar (HP:0011077)1.45544600
187* Oligohydramnios (HP:0001562)1.45491716

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.45770923
2STK164.45628062
3FRK3.59986234
4BUB13.39371826
5WNK43.24757386
6MAP4K23.06985457
7IRAK32.74129934
8ZAK2.62304962
9TXK2.32348428
10PINK12.10577487
11BMPR1B1.99375912
12STK391.94202315
13CDC71.90998555
14VRK11.83916125
15NEK21.83410372
16GRK61.80446051
17MKNK21.80121026
18MKNK11.78242237
19MAP3K141.72731870
20IRAK41.70717723
21SRPK11.67474934
22DYRK31.65714483
23PLK41.65075800
24BLK1.63963504
25TTK1.63899485
26INSRR1.62375499
27MAP4K11.61782737
28EIF2AK21.52945795
29NME21.51853876
30CHEK21.48242732
31IKBKB1.45486425
32BRD41.43856459
33CDK71.40839821
34OXSR11.40636956
35PLK11.39378233
36JAK31.36271677
37WNK31.36230212
38MAPK131.35867085
39RPS6KA41.33936109
40STK101.33625317
41TIE11.33450659
42BCKDK1.31758776
43CCNB11.30882689
44ATR1.30707751
45PIM11.27705231
46NLK1.27049709
47TLK11.24102350
48CLK11.22133671
49EPHA21.20355166
50PIK3CG1.18769809
51ADRBK21.18502583
52CDK31.17808521
53CHUK1.16845976
54CDK121.16788981
55STK41.15473052
56AURKB1.15139009
57TAOK21.10738747
58ACVR1B1.10469722
59MAP2K61.08028810
60VRK21.07788964
61IKBKE1.05646021
62WEE11.05075823
63YES11.04113275
64PIM21.03297577
65SYK1.02926058
66FES1.01939004
67TEC0.97194924
68GRK10.95382406
69BTK0.95017967
70DAPK20.94370567
71PASK0.93995628
72GRK70.93655075
73RPS6KA50.93123802
74NME10.92188769
75CHEK10.92064794
76ITK0.91787277
77IRAK10.91539276
78STK38L0.90477469
79BRSK20.87650793
80TESK20.87554861
81KDR0.86882490
82MATK0.84650161
83KIT0.84052606
84MST40.84029927
85TRPM70.82702328
86PRKCQ0.81058731
87MAPKAPK30.80700963
88PAK30.79477172
89ZAP700.78942134
90AKT30.78724041
91ADRBK10.77891933
92PLK30.76021128
93TSSK60.74014910
94TNK20.73884302
95PRKCI0.72869282
96SIK30.72701120
97MAP3K40.70899497
98LYN0.70521988
99PRKCE0.68988114
100NUAK10.68267588
101IRAK20.67817491
102SIK20.67172788
103AURKA0.66137104
104EPHA30.65461359
105ATM0.65093045
106PHKG10.64687220
107PHKG20.64687220
108DYRK20.64205130
109CSF1R0.63457132
110TYK20.62550162
111STK240.61252696
112CSNK1G20.61127910
113PRKCG0.60931671
114CDK40.60409215
115EIF2AK10.57074987
116SGK20.55858909
117EIF2AK30.55502413
118CDK80.54800084
119ERBB30.54616254
120TBK10.52859426
121MAP3K130.52070834
122TAF10.51916579
123IGF1R0.50702380
124PRPF4B0.50359780
125BRSK10.49897323
126PKN10.48714373
127PRKACA0.48326977
128TGFBR10.47450259
129GRK50.47292804
130CSNK2A10.47283811
131MUSK0.47164051
132RPS6KA60.47055952
133FLT30.46832573
134MAP3K80.46596407
135CASK0.46348406
136MAPK150.46285413
137CSNK1A10.45983253
138MAP2K20.45130883
139CSK0.44764629
140CSNK1G30.44573469
141CDK20.42877032
142CDK10.42861838
143NEK90.41582042
144PRKD20.41104832
145LCK0.40601901
146PIK3CA0.40364958
147RIPK40.40200683
148PRKCH0.39942673
149CAMK10.39863227
150PTK2B0.39424228
151PRKCA0.38881982
152CSNK1G10.34722129
153ABL10.34617621
154HIPK20.33021678
155MAPKAPK50.32892565
156HCK0.32621247
157MAP2K70.31166965
158PRKCD0.30142298
159MARK30.29796691
160PRKCZ0.29388629

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.99162492
2Mismatch repair_Homo sapiens_hsa034303.33417923
3Fanconi anemia pathway_Homo sapiens_hsa034603.32837070
4Base excision repair_Homo sapiens_hsa034103.16567617
5Homologous recombination_Homo sapiens_hsa034402.83493356
6Phototransduction_Homo sapiens_hsa047442.61012572
7One carbon pool by folate_Homo sapiens_hsa006702.57309648
8Nucleotide excision repair_Homo sapiens_hsa034202.46483278
9Non-homologous end-joining_Homo sapiens_hsa034502.43886373
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34097355
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22951199
12Cell cycle_Homo sapiens_hsa041102.20037199
13Graft-versus-host disease_Homo sapiens_hsa053322.19938605
14Oxidative phosphorylation_Homo sapiens_hsa001902.10705704
15RNA polymerase_Homo sapiens_hsa030202.07520484
16Primary immunodeficiency_Homo sapiens_hsa053402.05683812
17Linoleic acid metabolism_Homo sapiens_hsa005912.04062291
18Spliceosome_Homo sapiens_hsa030402.02037869
19Pyrimidine metabolism_Homo sapiens_hsa002401.99762014
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.99594843
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.98623922
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97682493
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.93151468
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.88595275
25Ribosome_Homo sapiens_hsa030101.82956571
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.79843034
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66041843
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.65353573
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.63876151
30Nitrogen metabolism_Homo sapiens_hsa009101.56416154
31RNA transport_Homo sapiens_hsa030131.55092633
32Tryptophan metabolism_Homo sapiens_hsa003801.54217688
33Parkinsons disease_Homo sapiens_hsa050121.51597609
34Basal transcription factors_Homo sapiens_hsa030221.47648767
35p53 signaling pathway_Homo sapiens_hsa041151.44640186
36Proteasome_Homo sapiens_hsa030501.44517166
37Caffeine metabolism_Homo sapiens_hsa002321.44074586
38Measles_Homo sapiens_hsa051621.42474649
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40993602
40Allograft rejection_Homo sapiens_hsa053301.39065867
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36690981
42Hematopoietic cell lineage_Homo sapiens_hsa046401.35499456
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35253541
44Nicotine addiction_Homo sapiens_hsa050331.34661860
45Antigen processing and presentation_Homo sapiens_hsa046121.34172703
46RNA degradation_Homo sapiens_hsa030181.33671976
47Herpes simplex infection_Homo sapiens_hsa051681.31493522
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19968010
49Butanoate metabolism_Homo sapiens_hsa006501.19436766
50Sulfur metabolism_Homo sapiens_hsa009201.18854588
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16673806
52Chemical carcinogenesis_Homo sapiens_hsa052041.16566286
53Purine metabolism_Homo sapiens_hsa002301.14043780
54Ether lipid metabolism_Homo sapiens_hsa005651.11139966
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09481386
56Autoimmune thyroid disease_Homo sapiens_hsa053201.06968174
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06658231
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.05789154
59Peroxisome_Homo sapiens_hsa041461.05599793
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05481507
61Olfactory transduction_Homo sapiens_hsa047401.03293559
62Small cell lung cancer_Homo sapiens_hsa052221.01034138
63mRNA surveillance pathway_Homo sapiens_hsa030151.00592113
64HTLV-I infection_Homo sapiens_hsa051661.00366809
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.99665928
66Morphine addiction_Homo sapiens_hsa050320.97537614
67Taste transduction_Homo sapiens_hsa047420.97361085
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97040297
69Epstein-Barr virus infection_Homo sapiens_hsa051690.96259158
70Systemic lupus erythematosus_Homo sapiens_hsa053220.93917047
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93232843
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93099878
73Huntingtons disease_Homo sapiens_hsa050160.88292557
74Vitamin B6 metabolism_Homo sapiens_hsa007500.88106663
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87831729
76Alzheimers disease_Homo sapiens_hsa050100.85825468
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84005680
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81815623
79Cardiac muscle contraction_Homo sapiens_hsa042600.81736355
80Apoptosis_Homo sapiens_hsa042100.81269669
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80198166
82Fat digestion and absorption_Homo sapiens_hsa049750.79377970
83Primary bile acid biosynthesis_Homo sapiens_hsa001200.79011730
84Glycerolipid metabolism_Homo sapiens_hsa005610.78940872
85Hepatitis B_Homo sapiens_hsa051610.76842110
86Notch signaling pathway_Homo sapiens_hsa043300.74846433
87Arachidonic acid metabolism_Homo sapiens_hsa005900.74529758
88Malaria_Homo sapiens_hsa051440.74382674
89Basal cell carcinoma_Homo sapiens_hsa052170.73550538
90Legionellosis_Homo sapiens_hsa051340.73369204
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72802222
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.72053210
93Viral carcinogenesis_Homo sapiens_hsa052030.71132861
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70582133
95Vitamin digestion and absorption_Homo sapiens_hsa049770.69724287
96MicroRNAs in cancer_Homo sapiens_hsa052060.68905078
97Influenza A_Homo sapiens_hsa051640.68580837
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.66567035
99Leishmaniasis_Homo sapiens_hsa051400.64343168
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62948786
101Asthma_Homo sapiens_hsa053100.61972906
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61887384
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61509969
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.57527928
105Serotonergic synapse_Homo sapiens_hsa047260.57448793
106Other glycan degradation_Homo sapiens_hsa005110.56891869
107Insulin secretion_Homo sapiens_hsa049110.56084110
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56059736
109Collecting duct acid secretion_Homo sapiens_hsa049660.53772132
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53658199
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52150941
112T cell receptor signaling pathway_Homo sapiens_hsa046600.50273015
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49550614
114Lysine degradation_Homo sapiens_hsa003100.48712751
115Metabolic pathways_Homo sapiens_hsa011000.48625502
116Regulation of autophagy_Homo sapiens_hsa041400.47764039
117Selenocompound metabolism_Homo sapiens_hsa004500.47126155
118Prostate cancer_Homo sapiens_hsa052150.46470843
119B cell receptor signaling pathway_Homo sapiens_hsa046620.46116860
120Propanoate metabolism_Homo sapiens_hsa006400.45965758
121Sulfur relay system_Homo sapiens_hsa041220.45838395
122TNF signaling pathway_Homo sapiens_hsa046680.45617835
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44502673
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.43778769
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43540504
126Protein export_Homo sapiens_hsa030600.42959745
127Ovarian steroidogenesis_Homo sapiens_hsa049130.42929440
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41368996
129Toxoplasmosis_Homo sapiens_hsa051450.41208128
130Glutathione metabolism_Homo sapiens_hsa004800.40985726
131Salivary secretion_Homo sapiens_hsa049700.40679269
132GABAergic synapse_Homo sapiens_hsa047270.40299220
133Staphylococcus aureus infection_Homo sapiens_hsa051500.39311029
134Shigellosis_Homo sapiens_hsa051310.39308648
135Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38911271
136Bladder cancer_Homo sapiens_hsa052190.38232917
137Circadian entrainment_Homo sapiens_hsa047130.38057496
138Chronic myeloid leukemia_Homo sapiens_hsa052200.33355844
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.33248850
140Pancreatic cancer_Homo sapiens_hsa052120.32956703
141Retinol metabolism_Homo sapiens_hsa008300.32204334
142Viral myocarditis_Homo sapiens_hsa054160.32192728
143Pathways in cancer_Homo sapiens_hsa052000.30655435
144Folate biosynthesis_Homo sapiens_hsa007900.30279467
145Rheumatoid arthritis_Homo sapiens_hsa053230.29675014
146Hedgehog signaling pathway_Homo sapiens_hsa043400.29265109
147Acute myeloid leukemia_Homo sapiens_hsa052210.28867505
148Hepatitis C_Homo sapiens_hsa051600.26794429
149Type I diabetes mellitus_Homo sapiens_hsa049400.25989849
150ABC transporters_Homo sapiens_hsa020100.25363113
151Osteoclast differentiation_Homo sapiens_hsa043800.24757579
152Sphingolipid metabolism_Homo sapiens_hsa006000.24729552
153ECM-receptor interaction_Homo sapiens_hsa045120.24494330
154TGF-beta signaling pathway_Homo sapiens_hsa043500.24095106

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »