NELFA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)4.86304756
2DNA replication checkpoint (GO:0000076)4.79763991
3mitotic metaphase plate congression (GO:0007080)4.69194751
4DNA strand elongation involved in DNA replication (GO:0006271)4.56883560
5DNA replication initiation (GO:0006270)4.51227190
6DNA unwinding involved in DNA replication (GO:0006268)4.38928850
7DNA strand elongation (GO:0022616)4.34429669
8protein localization to chromosome, centromeric region (GO:0071459)4.29106281
9telomere maintenance via semi-conservative replication (GO:0032201)4.22869114
10mitotic nuclear envelope disassembly (GO:0007077)4.21306239
11mitotic sister chromatid segregation (GO:0000070)4.07207780
12metaphase plate congression (GO:0051310)4.04202183
13nucleobase biosynthetic process (GO:0046112)3.97176620
14kinetochore organization (GO:0051383)3.94393136
15ribosomal small subunit biogenesis (GO:0042274)3.92190391
16regulation of spindle organization (GO:0090224)3.84977724
17membrane disassembly (GO:0030397)3.84706548
18nuclear envelope disassembly (GO:0051081)3.84706548
19DNA replication-dependent nucleosome organization (GO:0034723)3.80845574
20DNA replication-dependent nucleosome assembly (GO:0006335)3.80845574
21CENP-A containing nucleosome assembly (GO:0034080)3.78077439
22telomere maintenance via recombination (GO:0000722)3.77231584
23maturation of SSU-rRNA (GO:0030490)3.77194647
24attachment of spindle microtubules to kinetochore (GO:0008608)3.76693605
25nuclear pore organization (GO:0006999)3.76112243
26chromatin remodeling at centromere (GO:0031055)3.75088341
27kinetochore assembly (GO:0051382)3.74081819
28DNA deamination (GO:0045006)3.73437374
29mitotic chromosome condensation (GO:0007076)3.73112215
30ncRNA 3-end processing (GO:0043628)3.71904840
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70402026
32base-excision repair, AP site formation (GO:0006285)3.65191890
33DNA replication-independent nucleosome organization (GO:0034724)3.65083588
34DNA replication-independent nucleosome assembly (GO:0006336)3.65083588
35peptidyl-arginine omega-N-methylation (GO:0035247)3.64641209
36negative regulation of mRNA processing (GO:0050686)3.63841398
37sister chromatid segregation (GO:0000819)3.63360887
38translational termination (GO:0006415)3.62841462
39purine nucleobase biosynthetic process (GO:0009113)3.59001777
40mitotic recombination (GO:0006312)3.58611985
41establishment of chromosome localization (GO:0051303)3.57852021
42folic acid-containing compound biosynthetic process (GO:0009396)3.54675622
43nuclear pore complex assembly (GO:0051292)3.53471674
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53226686
45telomere maintenance via telomere lengthening (GO:0010833)3.51577247
46formation of translation preinitiation complex (GO:0001731)3.51019288
47translational elongation (GO:0006414)3.42276755
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.39060244
49IMP biosynthetic process (GO:0006188)3.38136795
50protein-DNA complex disassembly (GO:0032986)3.37486846
51nucleosome disassembly (GO:0006337)3.37486846
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.37157874
53negative regulation of chromosome segregation (GO:0051985)3.35201141
54ribosome biogenesis (GO:0042254)3.35012609
55spindle checkpoint (GO:0031577)3.32949459
56histone arginine methylation (GO:0034969)3.32826602
57protein localization to chromosome (GO:0034502)3.32697547
58pseudouridine synthesis (GO:0001522)3.32690288
59mitotic sister chromatid cohesion (GO:0007064)3.30818188
60regulation of chromosome segregation (GO:0051983)3.30718822
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.30167218
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.30167218
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.30167218
64negative regulation of sister chromatid segregation (GO:0033046)3.30167218
65positive regulation of chromosome segregation (GO:0051984)3.27924159
66mitotic spindle assembly checkpoint (GO:0007094)3.27069403
67spindle assembly checkpoint (GO:0071173)3.26998546
68negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25241881
69heterochromatin organization (GO:0070828)3.25017613
70histone exchange (GO:0043486)3.24229472
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23788204
72ribosomal small subunit assembly (GO:0000028)3.23481002
73regulation of mitotic spindle organization (GO:0060236)3.21551403
74mitotic spindle checkpoint (GO:0071174)3.21356695
75nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20339400
76meiotic chromosome segregation (GO:0045132)3.19347506
77chromatin assembly (GO:0031497)3.16472486
78rRNA transcription (GO:0009303)3.15760659
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15241860
80peptidyl-arginine N-methylation (GO:0035246)3.14209317
81peptidyl-arginine methylation (GO:0018216)3.14209317
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.11775131
83L-serine metabolic process (GO:0006563)3.10717598
84maturation of 5.8S rRNA (GO:0000460)3.10217922
85histone H2A acetylation (GO:0043968)3.10205034
86spliceosomal snRNP assembly (GO:0000387)3.10049595
87chromosome segregation (GO:0007059)3.09645155
88metallo-sulfur cluster assembly (GO:0031163)3.08652887
89iron-sulfur cluster assembly (GO:0016226)3.08652887
90protein K6-linked ubiquitination (GO:0085020)3.08063894
91behavioral response to nicotine (GO:0035095)3.07924572
92ribonucleoprotein complex biogenesis (GO:0022613)3.05786204
93DNA duplex unwinding (GO:0032508)3.05125523
94DNA geometric change (GO:0032392)3.04058967
95negative regulation of mRNA metabolic process (GO:1903312)3.03935285
96ribosome assembly (GO:0042255)3.03465064
97transcription-coupled nucleotide-excision repair (GO:0006283)3.03326509
98regulation of sister chromatid cohesion (GO:0007063)3.02299317
99regulation of sister chromatid segregation (GO:0033045)3.01960983
100regulation of mitotic sister chromatid separation (GO:0010965)3.01960983
101regulation of mitotic sister chromatid segregation (GO:0033047)3.01960983
102rRNA processing (GO:0006364)3.01733548
103pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.00786709
104IMP metabolic process (GO:0046040)2.99801128
105mRNA splicing, via spliceosome (GO:0000398)2.99538092
106RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.99538092
107RNA splicing, via transesterification reactions (GO:0000375)2.99516758
108regulation of double-strand break repair via homologous recombination (GO:0010569)2.98855220
109chromatin assembly or disassembly (GO:0006333)2.98274613
110ATP-dependent chromatin remodeling (GO:0043044)2.97648911
111pore complex assembly (GO:0046931)2.97240757
112opioid receptor signaling pathway (GO:0038003)2.96732937
113negative regulation of RNA splicing (GO:0033119)2.95990081
114nuclear envelope organization (GO:0006998)2.95597843
115protein complex disassembly (GO:0043241)2.94797647
116rRNA metabolic process (GO:0016072)2.93408405
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.93078194
118somatic hypermutation of immunoglobulin genes (GO:0016446)2.93078194
119DNA methylation (GO:0006306)2.92146087
120DNA alkylation (GO:0006305)2.92146087
121negative regulation of telomere maintenance (GO:0032205)2.90950354
122regulation of telomere maintenance via telomerase (GO:0032210)2.90433589
123intra-S DNA damage checkpoint (GO:0031573)2.90244954
124viral transcription (GO:0019083)2.90062804
125negative regulation of histone methylation (GO:0031061)2.89899552
126regulation of centrosome cycle (GO:0046605)2.89005335
127regulation of nuclear cell cycle DNA replication (GO:0033262)2.88453632
128telomere maintenance (GO:0000723)2.88142455
129viral life cycle (GO:0019058)2.86920942
130rRNA modification (GO:0000154)2.85759228
131* negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.84041800
132cellular protein complex disassembly (GO:0043624)2.84004011
133negative regulation of telomerase activity (GO:0051974)2.81650092
134mRNA splice site selection (GO:0006376)2.81583841
135tRNA modification (GO:0006400)2.78933229
136* negative regulation of DNA-templated transcription, elongation (GO:0032785)2.75768556
137SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.74154438
138macromolecular complex disassembly (GO:0032984)2.71954699
139gonadal mesoderm development (GO:0007506)2.71600016
140histone H3-K9 methylation (GO:0051567)2.70092574
141intracellular estrogen receptor signaling pathway (GO:0030520)2.68078359
142cotranslational protein targeting to membrane (GO:0006613)2.65979203
143translational initiation (GO:0006413)2.65597790
144protein targeting to ER (GO:0045047)2.62593515
145regulation of mitochondrial translation (GO:0070129)2.61006594
146establishment of mitochondrion localization (GO:0051654)2.59261632
147transcription from mitochondrial promoter (GO:0006390)2.58263887
148RNA localization (GO:0006403)2.57663663
149nuclear-transcribed mRNA catabolic process (GO:0000956)2.53762320
150UTP biosynthetic process (GO:0006228)2.52687490
151tRNA processing (GO:0008033)2.52665553
152base-excision repair (GO:0006284)2.52603823
153regulation of telomerase activity (GO:0051972)2.51316658
154pyrimidine nucleotide catabolic process (GO:0006244)2.50335999
155protein polyglutamylation (GO:0018095)2.49134622
156DNA modification (GO:0006304)2.47578205
157mRNA catabolic process (GO:0006402)2.45914568
158establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.45701733
159mitochondrion transport along microtubule (GO:0047497)2.45701733
160preassembly of GPI anchor in ER membrane (GO:0016254)2.45389565
161establishment of protein localization to endoplasmic reticulum (GO:0072599)2.45079023
162pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.45059657
163negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.44862622
164histone H4 deacetylation (GO:0070933)2.44623372
165ncRNA processing (GO:0034470)2.44580234
166mitochondrial RNA metabolic process (GO:0000959)2.44481693
167rRNA methylation (GO:0031167)2.44156643
168DNA methylation or demethylation (GO:0044728)2.43169107
169DNA methylation involved in gamete generation (GO:0043046)2.43159540
170piRNA metabolic process (GO:0034587)2.42567445
171cell migration in hindbrain (GO:0021535)2.42273016
172mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.41331923
173mitochondrial respiratory chain complex I assembly (GO:0032981)2.41331923
174NADH dehydrogenase complex assembly (GO:0010257)2.41331923
175protein localization to endoplasmic reticulum (GO:0070972)2.40545368
176positive regulation of gene expression, epigenetic (GO:0045815)2.40432422
177positive regulation of male gonad development (GO:2000020)2.39249826

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.18053597
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.86917228
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.50597143
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.13987861
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90156040
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62141378
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37185402
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93806229
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91843677
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.87109058
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79994639
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75804769
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.67084702
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.62043609
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52441477
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.51390965
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51194681
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45285420
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.40255820
20XRN2_22483619_ChIP-Seq_HELA_Human2.36528596
21E2F1_21310950_ChIP-Seq_MCF-7_Human2.26871819
22AR_21909140_ChIP-Seq_LNCAP_Human2.26462906
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18292521
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13967796
25VDR_23849224_ChIP-Seq_CD4+_Human2.13692922
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.02806424
27FOXP3_21729870_ChIP-Seq_TREG_Human1.99644019
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.99077535
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.96626489
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.96091367
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95886373
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92349506
33* CIITA_25753668_ChIP-Seq_RAJI_Human1.90566300
34GABP_19822575_ChIP-Seq_HepG2_Human1.90545119
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90345218
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.85920571
37P68_20966046_ChIP-Seq_HELA_Human1.85866945
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83407616
39MYC_22102868_ChIP-Seq_BL_Human1.83280202
40TTF2_22483619_ChIP-Seq_HELA_Human1.83257675
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.80534381
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79405895
43DCP1A_22483619_ChIP-Seq_HELA_Human1.78418553
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78317287
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75087038
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74971608
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73811512
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68027484
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60637417
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59915056
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57104625
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54912578
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.54831921
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53702915
55FOXP1_21924763_ChIP-Seq_HESCs_Human1.53549178
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.52632495
57KDM5A_27292631_Chip-Seq_BREAST_Human1.52618606
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51990285
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50261838
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.49369196
61EZH2_22144423_ChIP-Seq_EOC_Human1.49274576
62BCL6_27268052_Chip-Seq_Bcells_Human1.48119416
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47356817
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41776179
65LXR_22292898_ChIP-Seq_THP-1_Human1.39982787
66PHF8_20622854_ChIP-Seq_HELA_Human1.38963591
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38010184
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37696115
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37622298
70ELK1_19687146_ChIP-ChIP_HELA_Human1.34330728
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33134858
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32512495
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.32184700
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30168539
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29534632
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.28801556
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.28250916
78E2F1_20622854_ChIP-Seq_HELA_Human1.27868993
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.24839989
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24741334
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24280202
82SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22753952
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21795833
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.20686642
85BCOR_27268052_Chip-Seq_Bcells_Human1.20506250
86CTCF_27219007_Chip-Seq_Bcells_Human1.20196039
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19753392
88DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.19330343
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18804902
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18460732
91IRF1_19129219_ChIP-ChIP_H3396_Human1.18258219
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18188705
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17866515
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17865722
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.17132411
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.15359725
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14199987
98RARB_24833708_ChIP-Seq_LIVER_Mouse1.12965129
99PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12488562
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12332225
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10992337
102SMC4_20622854_ChIP-Seq_HELA_Human1.10870865
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09633377
104MAF_26560356_Chip-Seq_TH2_Human1.09211595
105KDM2B_26808549_Chip-Seq_DND41_Human1.09192358
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09128109
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.08976488
108TFEB_21752829_ChIP-Seq_HELA_Human1.08818095
109MYC_18940864_ChIP-ChIP_HL60_Human1.08791922
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.07569784
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.06827190
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06325624
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05082738
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04924459
115VDR_21846776_ChIP-Seq_THP-1_Human1.04231487
116SALL1_21062744_ChIP-ChIP_HESCs_Human1.03521201
117CTCF_20526341_ChIP-Seq_ESCs_Human1.03482349
118ERG_21242973_ChIP-ChIP_JURKAT_Human1.03215372
119PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01195351
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99846745
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98298262
122CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98258195
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98025897
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.96458110
125ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95061095
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88056749
127GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87750441
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85907022
129SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84416409
130NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83783580
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80312897
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79790679
133SPI1_23547873_ChIP-Seq_NB4_Human0.76247839
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.75723023
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.74890410
136TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73357631
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73209443

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.55348919
2MP0010094_abnormal_chromosome_stability4.73781949
3MP0003111_abnormal_nucleus_morphology4.68132275
4MP0004957_abnormal_blastocyst_morpholog4.26422818
5MP0008057_abnormal_DNA_replication4.25944360
6MP0003077_abnormal_cell_cycle4.11621490
7MP0008058_abnormal_DNA_repair3.32158899
8MP0008007_abnormal_cellular_replicative2.96071984
9MP0003123_paternal_imprinting2.80171333
10MP0008932_abnormal_embryonic_tissue2.66749511
11MP0008877_abnormal_DNA_methylation2.65523556
12MP0008995_early_reproductive_senescence2.34470848
13MP0001730_embryonic_growth_arrest2.32876388
14MP0002396_abnormal_hematopoietic_system2.31892866
15MP0000350_abnormal_cell_proliferation2.31377111
16MP0010352_gastrointestinal_tract_polyps1.90280371
17MP0003121_genomic_imprinting1.89746006
18MP0002163_abnormal_gland_morphology1.89310980
19MP0003136_yellow_coat_color1.84886159
20MP0009278_abnormal_bone_marrow1.82616386
21MP0003786_premature_aging1.81399412
22MP0005380_embryogenesis_phenotype1.81047728
23MP0001672_abnormal_embryogenesis/_devel1.81047728
24MP0010030_abnormal_orbit_morphology1.80741874
25MP0001697_abnormal_embryo_size1.78513867
26MP0002653_abnormal_ependyma_morphology1.75155854
27MP0002085_abnormal_embryonic_tissue1.74517524
28MP0003718_maternal_effect1.74060040
29MP0000490_abnormal_crypts_of1.62781711
30MP0010307_abnormal_tumor_latency1.62277200
31MP0003984_embryonic_growth_retardation1.61266625
32MP0002080_prenatal_lethality1.58240030
33MP0001529_abnormal_vocalization1.56231941
34MP0002088_abnormal_embryonic_growth/wei1.55900484
35MP0002084_abnormal_developmental_patter1.55859980
36MP0006292_abnormal_olfactory_placode1.55218825
37MP0000631_abnormal_neuroendocrine_gland1.52581444
38MP0004808_abnormal_hematopoietic_stem1.50886535
39MP0005645_abnormal_hypothalamus_physiol1.49647345
40MP0009379_abnormal_foot_pigmentation1.48994498
41MP0000566_synostosis1.47752199
42MP0001188_hyperpigmentation1.44375070
43MP0000313_abnormal_cell_death1.43306261
44MP0003878_abnormal_ear_physiology1.41664644
45MP0005377_hearing/vestibular/ear_phenot1.41664644
46MP0002210_abnormal_sex_determination1.40210427
47MP0005076_abnormal_cell_differentiation1.38796878
48MP0002086_abnormal_extraembryonic_tissu1.38240904
49MP0002019_abnormal_tumor_incidence1.37976982
50MP0003787_abnormal_imprinting1.37112373
51MP0001502_abnormal_circadian_rhythm1.35551578
52MP0003890_abnormal_embryonic-extraembry1.34998105
53MP0004197_abnormal_fetal_growth/weight/1.34726647
54MP0006072_abnormal_retinal_apoptosis1.33576371
55MP0000778_abnormal_nervous_system1.30229854
56MP0001968_abnormal_touch/_nociception1.29210228
57MP0005423_abnormal_somatic_nervous1.24119020
58MP0003315_abnormal_perineum_morphology1.23309102
59MP0001145_abnormal_male_reproductive1.19463811
60MP0004859_abnormal_synaptic_plasticity1.18821955
61MP0001293_anophthalmia1.18755743
62MP0001929_abnormal_gametogenesis1.16302693
63MP0003938_abnormal_ear_development1.15537610
64MP0005646_abnormal_pituitary_gland1.15178544
65MP0003567_abnormal_fetal_cardiomyocyte1.13314506
66MP0001986_abnormal_taste_sensitivity1.13252448
67MP0009333_abnormal_splenocyte_physiolog1.13089751
68MP0002938_white_spotting1.12929645
69MP0002234_abnormal_pharynx_morphology1.12845597
70MP0006035_abnormal_mitochondrial_morpho1.12446032
71MP0002822_catalepsy1.12406544
72MP0001919_abnormal_reproductive_system1.11847195
73MP0002102_abnormal_ear_morphology1.10022419
74MP0000653_abnormal_sex_gland1.09384191
75MP0003763_abnormal_thymus_physiology1.09052084
76MP0000703_abnormal_thymus_morphology1.07777618
77MP0001545_abnormal_hematopoietic_system1.06962799
78MP0005397_hematopoietic_system_phenotyp1.06962799
79MP0001119_abnormal_female_reproductive1.05761179
80MP0003937_abnormal_limbs/digits/tail_de1.03411855
81MP0004142_abnormal_muscle_tone1.03282995
82MP0004742_abnormal_vestibular_system1.02088955
83MP0001348_abnormal_lacrimal_gland1.00436779
84MP0000955_abnormal_spinal_cord1.00209069
85MP0004133_heterotaxia0.99046896
86MP0001984_abnormal_olfaction0.98983035
87MP0002751_abnormal_autonomic_nervous0.97855776
88MP0002557_abnormal_social/conspecific_i0.97758804
89MP0005253_abnormal_eye_physiology0.96599502
90MP0001346_abnormal_lacrimal_gland0.94926934
91MP0002254_reproductive_system_inflammat0.94492779
92MP0006276_abnormal_autonomic_nervous0.90370883
93MP0002398_abnormal_bone_marrow0.89622475
94MP0008872_abnormal_physiological_respon0.88992140
95MP0002736_abnormal_nociception_after0.88795283
96MP0005384_cellular_phenotype0.88431381
97MP0000537_abnormal_urethra_morphology0.87916084
98MP0002160_abnormal_reproductive_system0.87711561
99MP0000026_abnormal_inner_ear0.86929325
100MP0003119_abnormal_digestive_system0.86811385
101MP0002752_abnormal_somatic_nervous0.86117800
102MP0005391_vision/eye_phenotype0.83447458
103MP0002572_abnormal_emotion/affect_behav0.83387446
104MP0005551_abnormal_eye_electrophysiolog0.83021710
105MP0005083_abnormal_biliary_tract0.82624580
106MP0002152_abnormal_brain_morphology0.82160228
107MP0008789_abnormal_olfactory_epithelium0.82051782
108MP0009672_abnormal_birth_weight0.82028493
109MP0002722_abnormal_immune_system0.81978760
110MP0005621_abnormal_cell_physiology0.81821318
111MP0002184_abnormal_innervation0.81417957
112MP0001915_intracranial_hemorrhage0.81147929
113MP0002063_abnormal_learning/memory/cond0.79047379
114MP0001849_ear_inflammation0.78119990
115MP0000358_abnormal_cell_content/0.76870890
116MP0005220_abnormal_exocrine_pancreas0.76657062
117MP0001873_stomach_inflammation0.76627584
118MP0002111_abnormal_tail_morphology0.75384802
119MP0000689_abnormal_spleen_morphology0.74881517
120MP0002233_abnormal_nose_morphology0.73988760
121MP0002697_abnormal_eye_size0.73829964
122MP0002733_abnormal_thermal_nociception0.73583644
123MP0004264_abnormal_extraembryonic_tissu0.73552806
124MP0001485_abnormal_pinna_reflex0.73501199
125MP0004043_abnormal_pH_regulation0.72416622
126MP0002116_abnormal_craniofacial_bone0.72119104
127MP0000049_abnormal_middle_ear0.71559453
128MP0000858_altered_metastatic_potential0.71480479
129MP0002249_abnormal_larynx_morphology0.70681602
130MP0001286_abnormal_eye_development0.69525159
131MP0003941_abnormal_skin_development0.68434194
132MP0009703_decreased_birth_body0.68415005
133MP0005389_reproductive_system_phenotype0.68164197
134MP0003699_abnormal_female_reproductive0.67863816
135MP0003861_abnormal_nervous_system0.67319706
136MP0003935_abnormal_craniofacial_develop0.66105910
137MP0009053_abnormal_anal_canal0.65593920
138MP0004233_abnormal_muscle_weight0.64299409
139MP0000428_abnormal_craniofacial_morphol0.64218700
140MP0002429_abnormal_blood_cell0.63593915
141MP0002092_abnormal_eye_morphology0.63478529
142MP0000432_abnormal_head_morphology0.62867776
143MP0002932_abnormal_joint_morphology0.61498931
144MP0006054_spinal_hemorrhage0.61431196
145MP0003122_maternal_imprinting0.61378004
146MP0003755_abnormal_palate_morphology0.61001727
147MP0002127_abnormal_cardiovascular_syste0.60130995
148MP0003943_abnormal_hepatobiliary_system0.59919354
149MP0003806_abnormal_nucleotide_metabolis0.59161586
150MP0000678_abnormal_parathyroid_gland0.58367407
151MP0002161_abnormal_fertility/fecundity0.57966798
152MP0003698_abnormal_male_reproductive0.57124014
153MP0005394_taste/olfaction_phenotype0.57070784
154MP0005499_abnormal_olfactory_system0.57070784
155MP0002132_abnormal_respiratory_system0.56048129

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.13469218
2Breast hypoplasia (HP:0003187)4.25116074
3Chromsome breakage (HP:0040012)4.02494245
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83662837
5Patellar aplasia (HP:0006443)3.83050131
6Aplasia/Hypoplasia of the patella (HP:0006498)3.65590382
7Reticulocytopenia (HP:0001896)3.60535256
8Meckel diverticulum (HP:0002245)3.54332138
9Abnormality of the ileum (HP:0001549)3.39177934
10Abnormality of the preputium (HP:0100587)3.37543760
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.36256131
12Abnormality of chromosome stability (HP:0003220)3.32646439
13Medulloblastoma (HP:0002885)3.22006385
14Abnormality of the labia minora (HP:0012880)3.19922355
15Retinal dysplasia (HP:0007973)3.12105807
16Degeneration of anterior horn cells (HP:0002398)3.08180639
17Abnormality of the anterior horn cell (HP:0006802)3.08180639
18Selective tooth agenesis (HP:0001592)3.04174194
19Small intestinal stenosis (HP:0012848)3.01325555
20Duodenal stenosis (HP:0100867)3.01325555
21Carpal bone hypoplasia (HP:0001498)3.01282335
22Ependymoma (HP:0002888)2.93457253
23Oral leukoplakia (HP:0002745)2.89234558
24Absent thumb (HP:0009777)2.88543477
25Abnormal number of incisors (HP:0011064)2.82204908
26Abnormality of cells of the erythroid lineage (HP:0012130)2.82186375
27Absent radius (HP:0003974)2.81734471
28Myelodysplasia (HP:0002863)2.79719784
29Abnormal number of erythroid precursors (HP:0012131)2.79716565
30Supernumerary spleens (HP:0009799)2.76104625
31Impulsivity (HP:0100710)2.69249766
32Colon cancer (HP:0003003)2.68306448
33Ectopic kidney (HP:0000086)2.67807186
34Congenital stationary night blindness (HP:0007642)2.66645897
35Type II lissencephaly (HP:0007260)2.64404996
36Aplastic anemia (HP:0001915)2.64006343
37Facial hemangioma (HP:0000329)2.61466584
38Aplasia involving forearm bones (HP:0009822)2.61280070
39Absent forearm bone (HP:0003953)2.61280070
40* Sclerocornea (HP:0000647)2.60140433
41Rough bone trabeculation (HP:0100670)2.57329537
42Volvulus (HP:0002580)2.56058498
43Sloping forehead (HP:0000340)2.54605148
44Increased nuchal translucency (HP:0010880)2.52688033
45Bone marrow hypocellularity (HP:0005528)2.50182266
46Cerebellar dysplasia (HP:0007033)2.50033825
47Abnormality of the duodenum (HP:0002246)2.47015783
48Atresia of the external auditory canal (HP:0000413)2.46156169
49Nephronophthisis (HP:0000090)2.43400148
50Bilateral microphthalmos (HP:0007633)2.40973447
51Broad distal phalanx of finger (HP:0009836)2.40338622
52Abnormal lung lobation (HP:0002101)2.39222598
53Lissencephaly (HP:0001339)2.36697202
54Neoplasm of the pancreas (HP:0002894)2.35201259
55Rhabdomyosarcoma (HP:0002859)2.34985282
56Pancreatic fibrosis (HP:0100732)2.34640245
57Triphalangeal thumb (HP:0001199)2.34254984
58Agnosia (HP:0010524)2.33216596
59Hypoplasia of the pons (HP:0012110)2.32975721
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.31536948
61Abnormality of the carotid arteries (HP:0005344)2.29189197
62True hermaphroditism (HP:0010459)2.27005296
63Proximal placement of thumb (HP:0009623)2.26868703
64Tracheoesophageal fistula (HP:0002575)2.22408525
65Pancreatic cysts (HP:0001737)2.21505580
66Premature graying of hair (HP:0002216)2.20690885
67Abnormality of midbrain morphology (HP:0002418)2.18867425
68Molar tooth sign on MRI (HP:0002419)2.18867425
69Abnormality of DNA repair (HP:0003254)2.17852910
70Deviation of the thumb (HP:0009603)2.17486020
71Long eyelashes (HP:0000527)2.16674374
72Horseshoe kidney (HP:0000085)2.14867269
73Premature ovarian failure (HP:0008209)2.13861753
74Prominent nose (HP:0000448)2.13542751
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12326691
76Septo-optic dysplasia (HP:0100842)2.11946262
77Abnormality of the aortic arch (HP:0012303)2.11931748
78Optic nerve coloboma (HP:0000588)2.11602467
79Neoplasm of the oral cavity (HP:0100649)2.10383475
80Lipid accumulation in hepatocytes (HP:0006561)2.07852100
81Cystic liver disease (HP:0006706)2.06913436
82Cafe-au-lait spot (HP:0000957)2.06533038
8311 pairs of ribs (HP:0000878)2.02829130
84Nephroblastoma (Wilms tumor) (HP:0002667)2.02811340
85Clubbing of toes (HP:0100760)2.02792104
86Poikiloderma (HP:0001029)2.02120002
87Pachygyria (HP:0001302)2.01212077
88Short thumb (HP:0009778)2.00533292
89Microretrognathia (HP:0000308)2.00469367
90Septate vagina (HP:0001153)1.99164584
91Shawl scrotum (HP:0000049)1.98649680
92Abnormality of the pons (HP:0007361)1.98100836
93High pitched voice (HP:0001620)1.97856979
94Short 4th metacarpal (HP:0010044)1.97777328
95Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97777328
96Pallor (HP:0000980)1.97115646
97Hypoplasia of the uterus (HP:0000013)1.96680980
98Neoplasm of the adrenal cortex (HP:0100641)1.95087926
99Cerebral hypomyelination (HP:0006808)1.94397952
100Trismus (HP:0000211)1.94233583
101Embryonal renal neoplasm (HP:0011794)1.93704138
102* Preaxial hand polydactyly (HP:0001177)1.93309819
103Macrocytic anemia (HP:0001972)1.92319123
104Aplasia/hypoplasia of the uterus (HP:0008684)1.92242600
105Hypoplasia of the brainstem (HP:0002365)1.91419193
106Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91419193
107Squamous cell carcinoma (HP:0002860)1.90860086
108Cellular immunodeficiency (HP:0005374)1.90736584
109Sparse lateral eyebrow (HP:0005338)1.90145594
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89735121
111Anophthalmia (HP:0000528)1.89474257
112Neoplasm of striated muscle (HP:0009728)1.89184560
113Slender long bone (HP:0003100)1.88886629
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88872791
115Aplasia/hypoplasia of the humerus (HP:0006507)1.87983085
116Increased hepatocellular lipid droplets (HP:0006565)1.87265341
117Concave nail (HP:0001598)1.87116053
118Duplicated collecting system (HP:0000081)1.85737896
119Hepatocellular necrosis (HP:0001404)1.85301641
120Choanal atresia (HP:0000453)1.85039889
121Severe muscular hypotonia (HP:0006829)1.84980952
122Morphological abnormality of the inner ear (HP:0011390)1.84529414
123Rib fusion (HP:0000902)1.84449137
124* High anterior hairline (HP:0009890)1.83719084
125Basal cell carcinoma (HP:0002671)1.83679230
126Pendular nystagmus (HP:0012043)1.82773407
127Hypoplasia of the radius (HP:0002984)1.82283506
128Abnormality of reticulocytes (HP:0004312)1.81853700
129Trigonocephaly (HP:0000243)1.81045971
130Anencephaly (HP:0002323)1.81014745
131Capillary hemangiomas (HP:0005306)1.80514078
132Absent epiphyses (HP:0010577)1.80218670
133Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80218670
134Cleft eyelid (HP:0000625)1.79361290
135Mitochondrial inheritance (HP:0001427)1.78175196
136Slow-growing hair (HP:0002217)1.77628139
137Abnormality of hair growth rate (HP:0011363)1.77628139
138Secondary amenorrhea (HP:0000869)1.75764049
139Occipital encephalocele (HP:0002085)1.75679634
140Abnormality of the renal medulla (HP:0100957)1.75572994
141Acute lymphatic leukemia (HP:0006721)1.75292469
142Abnormal trabecular bone morphology (HP:0100671)1.73081633
143Abnormality of the metopic suture (HP:0005556)1.72749412
144Overlapping toe (HP:0001845)1.71954358
145Holoprosencephaly (HP:0001360)1.71022939
146Prominent metopic ridge (HP:0005487)1.70948577
147Abnormality of the fingertips (HP:0001211)1.70797961
148Breast aplasia (HP:0100783)1.70096437
149Aplasia/Hypoplasia of the breasts (HP:0010311)1.70022549
150Abnormality of the astrocytes (HP:0100707)1.69146297
151Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.68964344
152Aplasia/Hypoplasia of the spleen (HP:0010451)1.67734835
153Progressive microcephaly (HP:0000253)1.67562105
154Nephrogenic diabetes insipidus (HP:0009806)1.67099697
155Renal dysplasia (HP:0000110)1.66922258
156Polymicrogyria (HP:0002126)1.66659375
157Hyperglycinemia (HP:0002154)1.66553038
158Increased muscle lipid content (HP:0009058)1.64923092
159Supernumerary bones of the axial skeleton (HP:0009144)1.64220166
160Truncus arteriosus (HP:0001660)1.64139398
161Hypoplastic pelvis (HP:0008839)1.63837277
162Oligodactyly (HP:0012165)1.63828846
163Increased CSF lactate (HP:0002490)1.63314261
164Postaxial foot polydactyly (HP:0001830)1.63087769
165Abolished electroretinogram (ERG) (HP:0000550)1.62813174
166Increased serum lactate (HP:0002151)1.62419372
167Meningocele (HP:0002435)1.62222802
168Abnormality of the intervertebral disk (HP:0005108)1.61679995
169Hemivertebrae (HP:0002937)1.61499009
170Abnormality of the renal collecting system (HP:0004742)1.59483299
171Gait imbalance (HP:0002141)1.59226926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.87180913
2CDC74.24954928
3WEE14.11627014
4VRK23.35038860
5SMG13.33349410
6CDK123.02364421
7NEK23.00508203
8EIF2AK12.74510296
9TTK2.68039957
10BRSK22.53614021
11SIK22.53216817
12PLK12.30486305
13SRPK12.26674991
14TSSK62.06347834
15VRK12.05440331
16CDK72.03111277
17PLK41.93881416
18BRD41.93500096
19ACVR1B1.90528318
20EEF2K1.88783442
21NEK11.86444932
22ATR1.84717237
23DYRK31.83986008
24PLK31.82915620
25BCKDK1.80352935
26CHEK21.77793914
27ICK1.70473500
28AURKB1.69701801
29PASK1.67736283
30MAP2K21.67313612
31TRIB31.62934588
32BRSK11.62574916
33RPS6KB21.61992673
34TLK11.54918406
35MKNK11.53016717
36STK161.51822384
37BRAF1.51159424
38SIK11.50348793
39EIF2AK31.50143415
40CHEK11.44636973
41WNK41.41731530
42CDK191.40368536
43STK101.39614796
44RPS6KA41.39273014
45TYRO31.38885557
46CDK41.38374519
47AURKA1.37022966
48TESK21.36172004
49MKNK21.35988173
50NME11.34962943
51CCNB11.33567154
52NUAK11.27630491
53MAP3K101.27587565
54TGFBR11.26047049
55CDK81.23836561
56TAF11.23359788
57GRK11.22861977
58PIM21.21338094
59MAP3K91.20836857
60MAP3K81.17078872
61CSNK1G31.15343086
62NME21.09220388
63MAP4K21.07235876
64CAMK1D1.05785807
65MAPK151.04724335
66ATM1.00042022
67STK40.98772887
68MAP2K70.98027992
69CSNK1G20.95169717
70* CDK20.94777519
71TRIM280.94695510
72HIPK20.93626006
73NTRK20.93272690
74RPS6KA60.90724955
75DYRK1B0.88321324
76PAK40.87703433
77CSNK1A1L0.86185160
78MARK20.85891511
79MELK0.83316387
80LATS20.83309821
81PIM10.82756790
82PRKD30.80830337
83RPS6KC10.80291132
84RPS6KL10.80291132
85IKBKB0.79777704
86RAF10.77148939
87TNK20.76507264
88SCYL20.75830352
89CSNK1G10.75662510
90RPS6KA20.75392348
91STK30.74824016
92CDK10.74162058
93MAPKAPK30.71997742
94MAP3K40.70734570
95AKT30.69300876
96PRKD20.68611213
97FLT30.67562496
98PAK10.65631916
99EPHA20.64024725
100FGFR20.64019577
101CAMKK10.62581309
102PRKCI0.62241485
103CSNK2A20.60097275
104BMPR1B0.59210909
105MTOR0.58074397
106ARAF0.57530077
107EIF2AK20.57147931
108RPS6KA10.57136155
109ZAK0.56306338
110CDK90.55749744
111CSNK2A10.55577495
112INSRR0.55264632
113KDR0.51890998
114PKN20.51137059
115CHUK0.50960698
116TXK0.49898503
117MAP4K10.48539291
118LMTK20.48436835
119CDK60.47873320
120STK38L0.46898597
121PKN10.46866119
122TAOK10.45991392
123CAMK40.44153764
124PRKAA10.44078110
125WNK30.40991892
126LATS10.40427258
127ALK0.39553590
128DYRK20.36217257
129RPS6KA50.35337891
130CDK30.35270793
131MAPK140.35078012
132MAP3K60.34508290
133AKT20.34106301
134TAOK20.33373686
135BTK0.30781508
136PRKDC0.29933904
137MAP3K110.29476529
138CSNK1E0.29291921
139MAP2K30.27234775
140MAPKAPK20.26008099
141AKT10.25053671
142GSK3B0.24577162
143MAPK110.23995921
144MAPK10.22318421
145RPS6KB10.22078920
146KSR10.21602702
147MAPK90.20983746
148LRRK20.20832899
149YES10.20357371
150GRK60.18963100
151NLK0.16766750

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.98437438
2Mismatch repair_Homo sapiens_hsa034304.27847149
3Spliceosome_Homo sapiens_hsa030403.51141660
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49459163
5Base excision repair_Homo sapiens_hsa034103.30121822
6Cell cycle_Homo sapiens_hsa041103.28145170
7RNA polymerase_Homo sapiens_hsa030203.26293695
8Homologous recombination_Homo sapiens_hsa034403.26292406
9RNA transport_Homo sapiens_hsa030133.19784763
10Nucleotide excision repair_Homo sapiens_hsa034202.98074330
11Ribosome_Homo sapiens_hsa030102.83032591
12Fanconi anemia pathway_Homo sapiens_hsa034602.64196191
13One carbon pool by folate_Homo sapiens_hsa006702.47956558
14RNA degradation_Homo sapiens_hsa030182.41982541
15Proteasome_Homo sapiens_hsa030502.36608489
16Pyrimidine metabolism_Homo sapiens_hsa002402.36347368
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.28411789
18Non-homologous end-joining_Homo sapiens_hsa034502.25405825
19Basal transcription factors_Homo sapiens_hsa030222.25073419
20mRNA surveillance pathway_Homo sapiens_hsa030151.93259893
21p53 signaling pathway_Homo sapiens_hsa041151.75984503
22Oxidative phosphorylation_Homo sapiens_hsa001901.66380642
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59030218
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56281003
25Parkinsons disease_Homo sapiens_hsa050121.48715702
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.36330102
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.32245448
28Purine metabolism_Homo sapiens_hsa002301.29958069
29Steroid biosynthesis_Homo sapiens_hsa001001.29087618
30Epstein-Barr virus infection_Homo sapiens_hsa051691.23478197
31Oocyte meiosis_Homo sapiens_hsa041141.23466175
32Phototransduction_Homo sapiens_hsa047441.22856461
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20718469
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19296621
35Nicotine addiction_Homo sapiens_hsa050331.14330204
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.10491811
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09557744
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09144768
39Herpes simplex infection_Homo sapiens_hsa051681.06320923
40Viral carcinogenesis_Homo sapiens_hsa052030.98499329
41Ether lipid metabolism_Homo sapiens_hsa005650.94495230
42HTLV-I infection_Homo sapiens_hsa051660.90177142
43Thyroid cancer_Homo sapiens_hsa052160.85277299
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85246773
45Systemic lupus erythematosus_Homo sapiens_hsa053220.83729729
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83272441
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82196642
48MicroRNAs in cancer_Homo sapiens_hsa052060.78606023
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.78562050
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.76060384
51Notch signaling pathway_Homo sapiens_hsa043300.73912326
52Basal cell carcinoma_Homo sapiens_hsa052170.73532837
53Antigen processing and presentation_Homo sapiens_hsa046120.73347545
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71712225
55Folate biosynthesis_Homo sapiens_hsa007900.70370216
56Biosynthesis of amino acids_Homo sapiens_hsa012300.69719023
57Protein export_Homo sapiens_hsa030600.68696791
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68125528
59Colorectal cancer_Homo sapiens_hsa052100.67593101
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67106234
61Pentose phosphate pathway_Homo sapiens_hsa000300.66759602
62Sulfur relay system_Homo sapiens_hsa041220.61788479
63Linoleic acid metabolism_Homo sapiens_hsa005910.61467871
64Hippo signaling pathway_Homo sapiens_hsa043900.60718146
65Small cell lung cancer_Homo sapiens_hsa052220.59353339
66TGF-beta signaling pathway_Homo sapiens_hsa043500.58148433
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57892234
68Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55323273
69Alzheimers disease_Homo sapiens_hsa050100.54475797
70Primary immunodeficiency_Homo sapiens_hsa053400.53444781
71Selenocompound metabolism_Homo sapiens_hsa004500.52509159
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.51642878
73Chronic myeloid leukemia_Homo sapiens_hsa052200.48356787
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46577813
75N-Glycan biosynthesis_Homo sapiens_hsa005100.46022126
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45952384
77Cardiac muscle contraction_Homo sapiens_hsa042600.45087034
78Hedgehog signaling pathway_Homo sapiens_hsa043400.44807764
79Hepatitis B_Homo sapiens_hsa051610.44703890
80Axon guidance_Homo sapiens_hsa043600.44146280
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43681567
82Bladder cancer_Homo sapiens_hsa052190.43604477
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43597004
84Vitamin B6 metabolism_Homo sapiens_hsa007500.43248006
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.42019595
86Fatty acid elongation_Homo sapiens_hsa000620.40957714
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.40698433
88Alcoholism_Homo sapiens_hsa050340.40041148
89Apoptosis_Homo sapiens_hsa042100.37859503
90Pathways in cancer_Homo sapiens_hsa052000.37617113
91Adherens junction_Homo sapiens_hsa045200.34467501
92Legionellosis_Homo sapiens_hsa051340.33157733
93Measles_Homo sapiens_hsa051620.32810736
94VEGF signaling pathway_Homo sapiens_hsa043700.32657898
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31908684
96AMPK signaling pathway_Homo sapiens_hsa041520.31114358
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.30900661
98Pyruvate metabolism_Homo sapiens_hsa006200.30180086
99Pancreatic cancer_Homo sapiens_hsa052120.30060558
100Huntingtons disease_Homo sapiens_hsa050160.29783995
101Wnt signaling pathway_Homo sapiens_hsa043100.29625998
102Synaptic vesicle cycle_Homo sapiens_hsa047210.29620176
103Lysine degradation_Homo sapiens_hsa003100.27756817
104Cocaine addiction_Homo sapiens_hsa050300.27600879
105Morphine addiction_Homo sapiens_hsa050320.27106126
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26617011
107Non-small cell lung cancer_Homo sapiens_hsa052230.25858764
108Shigellosis_Homo sapiens_hsa051310.25756359
109Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25586097
110Prostate cancer_Homo sapiens_hsa052150.25533506
111Butanoate metabolism_Homo sapiens_hsa006500.25421859
112Acute myeloid leukemia_Homo sapiens_hsa052210.25375023
113Taste transduction_Homo sapiens_hsa047420.23781766
114mTOR signaling pathway_Homo sapiens_hsa041500.21574600
115Influenza A_Homo sapiens_hsa051640.21304514
116Melanogenesis_Homo sapiens_hsa049160.20887998
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.19470631
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19184742
119Endometrial cancer_Homo sapiens_hsa052130.19181925
120Ovarian steroidogenesis_Homo sapiens_hsa049130.18361975
121Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17701892
122MAPK signaling pathway_Homo sapiens_hsa040100.17598280
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17246657
124Dopaminergic synapse_Homo sapiens_hsa047280.16997460
125Vitamin digestion and absorption_Homo sapiens_hsa049770.16662586
126Circadian rhythm_Homo sapiens_hsa047100.15754013
127Glutathione metabolism_Homo sapiens_hsa004800.15701337
128FoxO signaling pathway_Homo sapiens_hsa040680.15320255
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.15245754
130HIF-1 signaling pathway_Homo sapiens_hsa040660.14890255
131Hematopoietic cell lineage_Homo sapiens_hsa046400.12894662
132Regulation of autophagy_Homo sapiens_hsa041400.12505243
133Carbon metabolism_Homo sapiens_hsa012000.11396009
134Fructose and mannose metabolism_Homo sapiens_hsa000510.10583994
135Melanoma_Homo sapiens_hsa052180.09948955
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09395854
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.08736075
1382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.07875181
139Jak-STAT signaling pathway_Homo sapiens_hsa046300.07314452
140Metabolic pathways_Homo sapiens_hsa011000.07074351

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