NELFB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.91662427
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.98666497
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.98666497
4viral transcription (GO:0019083)4.96804490
5maturation of SSU-rRNA (GO:0030490)4.83413290
6translational termination (GO:0006415)4.75193546
7translational elongation (GO:0006414)4.57766926
8antigen processing and presentation of endogenous antigen (GO:0019883)4.32398473
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.32032789
10regulation of mammary gland epithelial cell proliferation (GO:0033599)4.27767512
11DNA deamination (GO:0045006)4.20511779
12positive regulation of gamma-delta T cell activation (GO:0046645)4.19402009
13protein targeting to ER (GO:0045047)4.16915929
14cotranslational protein targeting to membrane (GO:0006613)4.15994232
15formation of translation preinitiation complex (GO:0001731)4.12988285
16apoptotic process involved in morphogenesis (GO:0060561)4.10156969
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.07372859
18ribosomal small subunit biogenesis (GO:0042274)4.05640373
19regulation of early endosome to late endosome transport (GO:2000641)4.04519358
20DNA unwinding involved in DNA replication (GO:0006268)4.03409222
21proline biosynthetic process (GO:0006561)4.03358635
22protein localization to endosome (GO:0036010)4.00889922
23translational initiation (GO:0006413)3.98126656
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.95292258
25protein localization to endoplasmic reticulum (GO:0070972)3.89309239
26regulation of gamma-delta T cell differentiation (GO:0045586)3.88223205
27protein retention in ER lumen (GO:0006621)3.88217967
28viral life cycle (GO:0019058)3.86376706
29Golgi transport vesicle coating (GO:0048200)3.76452623
30COPI coating of Golgi vesicle (GO:0048205)3.76452623
31adherens junction assembly (GO:0034333)3.75563577
32DNA strand elongation involved in DNA replication (GO:0006271)3.74816421
33negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.73246396
34maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73207248
35focal adhesion assembly (GO:0048041)3.70820952
36cell-substrate adherens junction assembly (GO:0007045)3.70820952
37cellular protein complex disassembly (GO:0043624)3.68517905
38activation of Rac GTPase activity (GO:0032863)3.62860469
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.57495538
40DNA strand elongation (GO:0022616)3.54057215
41negative regulation of cell size (GO:0045792)3.50087739
42protein complex disassembly (GO:0043241)3.47814266
43negative regulation of RNA splicing (GO:0033119)3.40855430
44antigen processing and presentation via MHC class Ib (GO:0002475)3.40296084
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.39575649
46regulation of gamma-delta T cell activation (GO:0046643)3.38498208
47barbed-end actin filament capping (GO:0051016)3.36790457
48nucleobase biosynthetic process (GO:0046112)3.36531368
49telomere maintenance via semi-conservative replication (GO:0032201)3.33798432
50maternal placenta development (GO:0001893)3.32631958
51folic acid-containing compound biosynthetic process (GO:0009396)3.31369830
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30404360
53cytoskeletal anchoring at plasma membrane (GO:0007016)3.28432666
54ribosomal large subunit biogenesis (GO:0042273)3.28418439
55macromolecular complex disassembly (GO:0032984)3.27376350
56positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.25136320
57positive thymic T cell selection (GO:0045059)3.21504938
58IMP biosynthetic process (GO:0006188)3.19848997
59nuclear-transcribed mRNA catabolic process (GO:0000956)3.18925508
60regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.16146722
61regulation of glucose import in response to insulin stimulus (GO:2001273)3.14255570
62negative regulation of erythrocyte differentiation (GO:0045647)3.13572532
63cell-substrate junction assembly (GO:0007044)3.11192409
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07438784
65negative regulation of cell killing (GO:0031342)3.07438784
66ribonucleoprotein complex biogenesis (GO:0022613)3.06255225
67heterochromatin organization (GO:0070828)3.04662961
683-UTR-mediated mRNA stabilization (GO:0070935)3.04080001
69protein localization to kinetochore (GO:0034501)3.01679321
70mRNA catabolic process (GO:0006402)3.01264822
71pinocytosis (GO:0006907)2.99690179
72positive regulation of Cdc42 GTPase activity (GO:0043089)2.99365470
73glucose catabolic process (GO:0006007)2.96975021
74modulation by symbiont of host cellular process (GO:0044068)2.95165246
75mannose metabolic process (GO:0006013)2.94969165
76spliceosomal tri-snRNP complex assembly (GO:0000244)2.94719352
77RNA catabolic process (GO:0006401)2.93846009
78purine nucleobase biosynthetic process (GO:0009113)2.92778867
79mitotic nuclear envelope disassembly (GO:0007077)2.90519999
80stress fiber assembly (GO:0043149)2.89657098
81epithelial cell differentiation involved in prostate gland development (GO:0060742)2.87881438
82DNA replication initiation (GO:0006270)2.87852146
83modulation by virus of host process (GO:0019054)2.86595204
84activation of MAPKKK activity (GO:0000185)2.85616044
85translation (GO:0006412)2.83906809
86Arp2/3 complex-mediated actin nucleation (GO:0034314)2.82197778
87telomere maintenance via recombination (GO:0000722)2.82102149
88positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.82082755
89dosage compensation (GO:0007549)2.80782266
90intracellular estrogen receptor signaling pathway (GO:0030520)2.79169164
91ncRNA 3-end processing (GO:0043628)2.79097518
92semaphorin-plexin signaling pathway (GO:0071526)2.79041634
93protein complex localization (GO:0031503)2.78982395
94protein maturation by protein folding (GO:0022417)2.78820595
95IMP metabolic process (GO:0046040)2.78530111
96protein targeting to membrane (GO:0006612)2.78116858
97cellular protein complex localization (GO:0034629)2.77206581
98telomere maintenance via telomere lengthening (GO:0010833)2.77201966
99pentose-phosphate shunt (GO:0006098)2.75300274
100NADPH regeneration (GO:0006740)2.74480667
101ribosome biogenesis (GO:0042254)2.74318572
102epithelial cell-cell adhesion (GO:0090136)2.72777415
103basement membrane organization (GO:0071711)2.71997827
104nuclear envelope disassembly (GO:0051081)2.70843163
105membrane disassembly (GO:0030397)2.70843163
106regulation of chromatin binding (GO:0035561)2.69361208
107modulation by virus of host morphology or physiology (GO:0019048)2.69287266
108cellular response to interleukin-4 (GO:0071353)2.69088140
109deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.65972797
110regulation of NFAT protein import into nucleus (GO:0051532)2.64926043
111UV protection (GO:0009650)2.62670421
112glucose 6-phosphate metabolic process (GO:0051156)2.62658571
113peptidyl-arginine omega-N-methylation (GO:0035247)2.61996611
114galactose catabolic process (GO:0019388)2.61857346
115mitotic recombination (GO:0006312)2.61552295
116protein-DNA complex disassembly (GO:0032986)2.60636113
117nucleosome disassembly (GO:0006337)2.60636113
118apoptotic process involved in development (GO:1902742)2.59938978
119translesion synthesis (GO:0019985)2.59861583
120regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.58982557
121activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.58334161
122mRNA stabilization (GO:0048255)2.57071232
123RNA stabilization (GO:0043489)2.57071232
124negative regulation of mRNA processing (GO:0050686)2.56904100
125regulation of translational fidelity (GO:0006450)2.55888927
126positive regulation of protein dephosphorylation (GO:0035307)2.54940028
127proline metabolic process (GO:0006560)2.54890018
128endosome to pigment granule transport (GO:0043485)2.54507628
129endosome to melanosome transport (GO:0035646)2.54507628
130protein targeting to plasma membrane (GO:0072661)2.54114500
131cellular response to epidermal growth factor stimulus (GO:0071364)2.53098706
132positive regulation of nuclease activity (GO:0032075)2.52865550
133regulation of translational termination (GO:0006449)2.52356636
134embryonic process involved in female pregnancy (GO:0060136)2.52213002
135rRNA processing (GO:0006364)2.52040699
136snRNA metabolic process (GO:0016073)2.50267198
137tRNA aminoacylation for protein translation (GO:0006418)2.50096048
138mitotic chromosome condensation (GO:0007076)2.49994694
139cell-cell junction maintenance (GO:0045217)2.49107078
140T cell apoptotic process (GO:0070231)2.48515043
141snRNA processing (GO:0016180)2.48365708
142endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.47437145
143response to laminar fluid shear stress (GO:0034616)2.47349555
144regulation of protein heterodimerization activity (GO:0043497)2.46311327
145regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.45472528
146mRNA splicing, via spliceosome (GO:0000398)2.44546972
147RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.44546972
148DNA duplex unwinding (GO:0032508)2.44309868
149histone H2A acetylation (GO:0043968)2.44214585
150histone arginine methylation (GO:0034969)2.44114401
151negative regulation of myotube differentiation (GO:0010832)2.43616425
152nucleotide-excision repair, DNA gap filling (GO:0006297)2.43370275
153rRNA metabolic process (GO:0016072)2.43353982
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.43037513
155regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.41652805
156positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.41652805
157RNA splicing, via transesterification reactions (GO:0000375)2.40872840
158spliceosomal snRNP assembly (GO:0000387)2.40457044
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.40195159
160NADH metabolic process (GO:0006734)2.39385652
161tRNA aminoacylation (GO:0043039)2.39259314
162amino acid activation (GO:0043038)2.39259314
163DNA geometric change (GO:0032392)2.39015574
164protein localization to chromosome, centromeric region (GO:0071459)2.38708830
165negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.38458878
166regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.37249632
167mitotic G1 DNA damage checkpoint (GO:0031571)2.36945424
168negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.36453451
169negative regulation of fatty acid transport (GO:2000192)2.36448939
170negative regulation of histone methylation (GO:0031061)2.36019210
171regulation of extracellular matrix disassembly (GO:0010715)2.35869886
172negative T cell selection (GO:0043383)2.35507683
173negative regulation of striated muscle cell differentiation (GO:0051154)2.35250482
174response to interleukin-4 (GO:0070670)2.34926031
175peptidyl-arginine N-methylation (GO:0035246)2.33713358
176peptidyl-arginine methylation (GO:0018216)2.33713358
177ribosome assembly (GO:0042255)2.32800301
178negative regulation of viral release from host cell (GO:1902187)2.31665369
179protein export from nucleus (GO:0006611)2.30411092
180positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.28329048
181positive regulation of receptor recycling (GO:0001921)2.28242701
182regulation of defense response to virus by virus (GO:0050690)2.26353316
183mitotic nuclear envelope reassembly (GO:0007084)2.26023978
184nuclear envelope reassembly (GO:0031468)2.26023978
185branching involved in mammary gland duct morphogenesis (GO:0060444)2.25771558
186nucleobase-containing small molecule interconversion (GO:0015949)2.24424195
187amyloid precursor protein catabolic process (GO:0042987)2.24227675
188regulation of nuclease activity (GO:0032069)2.23618670
189positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.23250300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.73172934
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.85363473
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.30497020
4MYC_22102868_ChIP-Seq_BL_Human2.97682746
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.80058370
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.71175034
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.46130563
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43371893
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42656779
10VDR_21846776_ChIP-Seq_THP-1_Human2.27237230
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24080325
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23657905
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.22180937
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19250061
15XRN2_22483619_ChIP-Seq_HELA_Human2.16580548
16RACK7_27058665_Chip-Seq_MCF-7_Human2.14915125
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.11418081
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.09259075
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.07216757
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.06178924
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.06089812
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04775524
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04257590
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04113555
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00605600
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.96583186
27CIITA_25753668_ChIP-Seq_RAJI_Human1.89810833
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.88520673
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88281192
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81934802
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.80027146
32KDM2B_26808549_Chip-Seq_K562_Human1.73725801
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.72373993
34VDR_23849224_ChIP-Seq_CD4+_Human1.71369755
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71188899
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71132218
37ZFP281_18757296_ChIP-ChIP_E14_Mouse1.68129296
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.67187787
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.63765152
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61667640
41GABP_19822575_ChIP-Seq_HepG2_Human1.60722465
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60643050
43FOXP3_21729870_ChIP-Seq_TREG_Human1.58656382
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56095417
45P68_20966046_ChIP-Seq_HELA_Human1.55880553
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55694393
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54482478
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54105915
49UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.53312270
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53161545
51DCP1A_22483619_ChIP-Seq_HELA_Human1.52285988
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.48359883
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47849626
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.47458503
55MAF_26560356_Chip-Seq_TH1_Human1.47016584
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.44683797
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44638533
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44548874
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44547933
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44282201
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43994259
62UTX_26944678_Chip-Seq_JUKART_Human1.43432670
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.39215639
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.38553971
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.37115102
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36170708
67TTF2_22483619_ChIP-Seq_HELA_Human1.36043923
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35770289
69TCF7_22412390_ChIP-Seq_EML_Mouse1.35418053
70MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34935300
71SPI1_23547873_ChIP-Seq_NB4_Human1.34477072
72THAP11_20581084_ChIP-Seq_MESCs_Mouse1.32610039
73CLOCK_20551151_ChIP-Seq_293T_Human1.32588319
74SMC4_20622854_ChIP-Seq_HELA_Human1.32285519
75IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30993963
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30817827
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30437080
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29691953
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29633774
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.28997493
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.28549334
82CREB1_26743006_Chip-Seq_LNCaP_Human1.27789337
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27464895
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26964563
85KDM5A_27292631_Chip-Seq_BREAST_Human1.26136983
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26048458
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25959589
88IRF8_22096565_ChIP-ChIP_GC-B_Human1.25783601
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25482395
90SCL_19346495_ChIP-Seq_HPC-7_Human1.25475576
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25425253
92FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24882692
93MYB_26560356_Chip-Seq_TH2_Human1.24605638
94ATF3_27146783_Chip-Seq_COLON_Human1.23902379
95NCOR1_26117541_ChIP-Seq_K562_Human1.23574971
96TFEB_21752829_ChIP-Seq_HELA_Human1.23443242
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.21395450
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20975956
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.20478384
100VDR_24763502_ChIP-Seq_THP-1_Human1.19587280
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19575755
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18693190
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18676658
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18582151
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18290337
106NOTCH1_21737748_ChIP-Seq_TLL_Human1.18057791
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17329713
108MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17039442
109STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16554814
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.15820500
111AR_21909140_ChIP-Seq_LNCAP_Human1.15771290
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15452938
113ZNF263_19887448_ChIP-Seq_K562_Human1.15120937
114MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14939806
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.14567020
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14538236
117GATA1_22025678_ChIP-Seq_K562_Human1.14378579
118MAF_26560356_Chip-Seq_TH2_Human1.14019638
119MYB_26560356_Chip-Seq_TH1_Human1.12078265
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11718219
121RUNX1_22412390_ChIP-Seq_EML_Mouse1.10849943
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10781161
123TP53_22127205_ChIP-Seq_IMR90_Human1.09293908
124KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08856268
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08783664
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07348049
127LXR_22292898_ChIP-Seq_THP-1_Human1.07304225
128NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06742780
129ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05871987
130KDM2B_26808549_Chip-Seq_DND41_Human1.05484891
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05406060
132ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05253660
133CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05125682
134KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03593622
135* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02920206
136BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02513895
137YY1_21170310_ChIP-Seq_MESCs_Mouse1.01893916
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01435368
139BCOR_27268052_Chip-Seq_Bcells_Human1.01385637
140STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01007826
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.00924737
142SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00541927
143CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00397548
144BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00267429
145SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00044022
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98560559
147TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98432964
148POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98251470
149YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98179477
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97616776
151ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97399673
152OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97094261
153CTCF_26484167_Chip-Seq_Bcells_Mouse0.95844612
154CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94890741

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.86047070
2MP0005451_abnormal_body_composition3.34511870
3MP0002396_abnormal_hematopoietic_system3.04489080
4MP0005058_abnormal_lysosome_morphology2.83132244
5MP0004957_abnormal_blastocyst_morpholog2.81732273
6MP0003763_abnormal_thymus_physiology2.77669474
7MP0003111_abnormal_nucleus_morphology2.71348412
8MP0004858_abnormal_nervous_system2.64945121
9MP0006054_spinal_hemorrhage2.60964610
10MP0003077_abnormal_cell_cycle2.59909602
11MP0004185_abnormal_adipocyte_glucose2.59874089
12MP0010352_gastrointestinal_tract_polyps2.58053898
13MP0010094_abnormal_chromosome_stability2.57938196
14MP0000685_abnormal_immune_system2.39535769
15MP0004808_abnormal_hematopoietic_stem2.25520820
16MP0008260_abnormal_autophagy2.24747991
17MP0008438_abnormal_cutaneous_collagen2.10685563
18MP0009333_abnormal_splenocyte_physiolog2.07161493
19MP0003453_abnormal_keratinocyte_physiol1.99876069
20MP0000678_abnormal_parathyroid_gland1.99452638
21MP0005671_abnormal_response_to1.98335256
22MP0002398_abnormal_bone_marrow1.96462490
23MP0008007_abnormal_cellular_replicative1.90569446
24MP0000490_abnormal_crypts_of1.88996903
25MP0003866_abnormal_defecation1.88410805
26MP0003300_gastrointestinal_ulcer1.86817744
27MP0002796_impaired_skin_barrier1.86387792
28MP0005409_darkened_coat_color1.86172742
29MP0002722_abnormal_immune_system1.77041949
30MP0001730_embryonic_growth_arrest1.76200865
31MP0000703_abnormal_thymus_morphology1.74412634
32MP0001835_abnormal_antigen_presentation1.72892614
33MP0001800_abnormal_humoral_immune1.72636843
34MP0005257_abnormal_intraocular_pressure1.71525176
35MP0003303_peritoneal_inflammation1.68558164
36MP0009278_abnormal_bone_marrow1.68371850
37MP0005397_hematopoietic_system_phenotyp1.68143500
38MP0001545_abnormal_hematopoietic_system1.68143500
39MP0000689_abnormal_spleen_morphology1.68015110
40MP0002249_abnormal_larynx_morphology1.67893783
41MP0005623_abnormal_meninges_morphology1.67800770
42MP0005666_abnormal_adipose_tissue1.67440471
43MP0001873_stomach_inflammation1.65598811
44MP0003191_abnormal_cellular_cholesterol1.63849535
45MP0005501_abnormal_skin_physiology1.61366016
46MP0008058_abnormal_DNA_repair1.60221500
47MP0004233_abnormal_muscle_weight1.59820977
48MP0000465_gastrointestinal_hemorrhage1.59677298
49MP0000350_abnormal_cell_proliferation1.59204901
50MP0002019_abnormal_tumor_incidence1.58651694
51MP0002420_abnormal_adaptive_immunity1.55104699
52MP0001348_abnormal_lacrimal_gland1.54518601
53MP0000716_abnormal_immune_system1.53303795
54MP0002429_abnormal_blood_cell1.52714276
55MP0001819_abnormal_immune_cell1.52360899
56MP0009379_abnormal_foot_pigmentation1.51788641
57MP0009785_altered_susceptibility_to1.48917597
58MP0000858_altered_metastatic_potential1.48728723
59MP0010155_abnormal_intestine_physiology1.47139365
60MP0002452_abnormal_antigen_presenting1.46638202
61MP0003329_amyloid_beta_deposits1.45831701
62MP0000733_abnormal_muscle_development1.44656578
63MP0003091_abnormal_cell_migration1.44328593
64MP0010234_abnormal_vibrissa_follicle1.42698929
65MP0003123_paternal_imprinting1.39296077
66MP0003436_decreased_susceptibility_to1.39086259
67MP0002723_abnormal_immune_serum1.38324481
68MP0005375_adipose_tissue_phenotype1.36892317
69MP0002405_respiratory_system_inflammati1.33946195
70MP0005025_abnormal_response_to1.33533142
71MP0010307_abnormal_tumor_latency1.31438943
72MP0005076_abnormal_cell_differentiation1.30098829
73MP0000003_abnormal_adipose_tissue1.28693128
74MP0000751_myopathy1.27022997
75MP0002080_prenatal_lethality1.25884539
76MP0008057_abnormal_DNA_replication1.25866254
77MP0009672_abnormal_birth_weight1.25547357
78MP0005023_abnormal_wound_healing1.24996403
79MP0004272_abnormal_basement_membrane1.23693530
80MP0000313_abnormal_cell_death1.22634966
81MP0002166_altered_tumor_susceptibility1.22631703
82MP0005000_abnormal_immune_tolerance1.21878452
83MP0001790_abnormal_immune_system1.21844049
84MP0005387_immune_system_phenotype1.21844049
85MP0002089_abnormal_postnatal_growth/wei1.19607289
86MP0001697_abnormal_embryo_size1.19555217
87MP0003705_abnormal_hypodermis_morpholog1.19369440
88MP0002132_abnormal_respiratory_system1.18201823
89MP0009053_abnormal_anal_canal1.18078798
90MP0002060_abnormal_skin_morphology1.18001264
91MP0005464_abnormal_platelet_physiology1.14323200
92MP0000477_abnormal_intestine_morphology1.13842957
93MP0001849_ear_inflammation1.13716221
94MP0004947_skin_inflammation1.12379753
95MP0003566_abnormal_cell_adhesion1.10957007
96MP0008932_abnormal_embryonic_tissue1.10287293
97MP0001853_heart_inflammation1.08910487
98MP0003567_abnormal_fetal_cardiomyocyte1.07791728
99MP0003984_embryonic_growth_retardation1.07595157
100MP0000747_muscle_weakness1.06795370
101MP0002088_abnormal_embryonic_growth/wei1.05423334
102MP0005174_abnormal_tail_pigmentation1.05384532
103MP0001672_abnormal_embryogenesis/_devel1.04205251
104MP0005380_embryogenesis_phenotype1.04205251
105MP0005220_abnormal_exocrine_pancreas1.03885471
106MP0001845_abnormal_inflammatory_respons1.03559541
107MP0002086_abnormal_extraembryonic_tissu1.03083829
108MP0000759_abnormal_skeletal_muscle1.02601625
109MP0004197_abnormal_fetal_growth/weight/1.01317760
110MP0010630_abnormal_cardiac_muscle0.99612763
111MP0000358_abnormal_cell_content/0.97459294
112MP0002877_abnormal_melanocyte_morpholog0.96978201
113MP0002084_abnormal_developmental_patter0.95742268
114MP0003221_abnormal_cardiomyocyte_apopto0.95262819
115MP0003279_aneurysm0.93970116
116MP0000566_synostosis0.93712124
117MP0004087_abnormal_muscle_fiber0.91973979
118MP0000681_abnormal_thyroid_gland0.90764278
119MP0001958_emphysema0.88161183
120MP0003786_premature_aging0.87264968
121MP0009931_abnormal_skin_appearance0.87201054
122MP0000750_abnormal_muscle_regeneration0.86848543
123MP0004510_myositis0.85894294
124MP0003172_abnormal_lysosome_physiology0.85019592
125MP0001346_abnormal_lacrimal_gland0.85013007
126MP0000762_abnormal_tongue_morphology0.84916260
127MP0004264_abnormal_extraembryonic_tissu0.84842782
128MP0001216_abnormal_epidermal_layer0.84059307
129MP0001915_intracranial_hemorrhage0.83868532
130MP0010030_abnormal_orbit_morphology0.83672781
131MP0002085_abnormal_embryonic_tissue0.83564603
132MP0005075_abnormal_melanosome_morpholog0.83236267
133MP0000467_abnormal_esophagus_morphology0.82836945
134MP0002419_abnormal_innate_immunity0.82787095
135MP0000767_abnormal_smooth_muscle0.82380797
136MP0003634_abnormal_glial_cell0.82151785
137MP0000579_abnormal_nail_morphology0.81695915
138MP0001270_distended_abdomen0.77610851
139MP0002933_joint_inflammation0.77115557
140MP0009840_abnormal_foam_cell0.75517532
141MP0005670_abnormal_white_adipose0.74269589
142MP0000537_abnormal_urethra_morphology0.74189946
143MP0003075_altered_response_to0.73909966
144MP0001661_extended_life_span0.73789278
145MP0003115_abnormal_respiratory_system0.73213646
146MP0000462_abnormal_digestive_system0.72943330
147MP0000371_diluted_coat_color0.72670344
148MP0005621_abnormal_cell_physiology0.71712550
149MP0005384_cellular_phenotype0.70337322
150MP0009384_cardiac_valve_regurgitation0.69852124
151MP0001663_abnormal_digestive_system0.69583749
152MP0003942_abnormal_urinary_system0.69414144
153MP0002998_abnormal_bone_remodeling0.68724978
154MP0001533_abnormal_skeleton_physiology0.66957053
155MP0001944_abnormal_pancreas_morphology0.65897964
156MP0008469_abnormal_protein_level0.65423092

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.58937977
2Abnormal number of erythroid precursors (HP:0012131)4.38679998
3Thrombocytosis (HP:0001894)3.86316410
4Chronic otitis media (HP:0000389)3.66955075
5Reticulocytopenia (HP:0001896)3.63134495
6Elevated erythrocyte sedimentation rate (HP:0003565)3.51877702
7IgM deficiency (HP:0002850)3.35500058
8Nasal polyposis (HP:0100582)3.23639067
9Colon cancer (HP:0003003)3.19468124
10Abnormality of the nasal mucosa (HP:0000433)3.12506806
11Recurrent bronchitis (HP:0002837)3.09115772
12Premature rupture of membranes (HP:0001788)3.05665090
13Achilles tendon contracture (HP:0001771)2.98372402
14Ulnar bowing (HP:0003031)2.96270222
15Distal lower limb amyotrophy (HP:0008944)2.96170637
16T lymphocytopenia (HP:0005403)2.95479132
1711 pairs of ribs (HP:0000878)2.86647461
18Broad face (HP:0000283)2.86042094
19Abnormality of T cells (HP:0002843)2.84321797
20Vertebral compression fractures (HP:0002953)2.81625491
21Increased connective tissue (HP:0009025)2.75594629
22Insomnia (HP:0100785)2.74488113
23Gastrointestinal inflammation (HP:0004386)2.72116487
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.67908458
25Abnormality of T cell number (HP:0011839)2.66889813
26Aplastic anemia (HP:0001915)2.65108547
27Centrally nucleated skeletal muscle fibers (HP:0003687)2.63011349
28Abnormality of the Achilles tendon (HP:0005109)2.62768310
29Selective tooth agenesis (HP:0001592)2.54503646
30Myositis (HP:0100614)2.54009873
31Distal lower limb muscle weakness (HP:0009053)2.52677867
32Abnormality of T cell physiology (HP:0011840)2.47042787
33Long palpebral fissure (HP:0000637)2.44641955
34Inflammation of the large intestine (HP:0002037)2.43695892
35Disproportionate tall stature (HP:0001519)2.40728167
36Pallor (HP:0000980)2.40423318
37Broad distal phalanx of finger (HP:0009836)2.39823162
38Distal upper limb amyotrophy (HP:0007149)2.38309085
39Upper limb amyotrophy (HP:0009129)2.38309085
40Microretrognathia (HP:0000308)2.37195320
41Recurrent viral infections (HP:0004429)2.36661300
42Obstructive sleep apnea (HP:0002870)2.36416187
43Basal cell carcinoma (HP:0002671)2.35880095
44Fragile skin (HP:0001030)2.35781482
45Shallow orbits (HP:0000586)2.35139655
46Hyperacusis (HP:0010780)2.35030499
47Multiple enchondromatosis (HP:0005701)2.34080930
48Amaurosis fugax (HP:0100576)2.28554449
49Macrocytic anemia (HP:0001972)2.27330880
50Degeneration of anterior horn cells (HP:0002398)2.25212596
51Abnormality of the anterior horn cell (HP:0006802)2.25212596
52Panhypogammaglobulinemia (HP:0003139)2.24818315
53Colitis (HP:0002583)2.24473641
54Petechiae (HP:0000967)2.23903643
55Increased variability in muscle fiber diameter (HP:0003557)2.22640630
56Ependymoma (HP:0002888)2.21503682
57Neoplasm of the pancreas (HP:0002894)2.19092063
58Interstitial pulmonary disease (HP:0006530)2.16988595
59Lower limb amyotrophy (HP:0007210)2.16378358
60Flat acetabular roof (HP:0003180)2.16101884
61Stridor (HP:0010307)2.12366161
62Oral leukoplakia (HP:0002745)2.12319214
63Spinal rigidity (HP:0003306)2.11761066
64Short nail (HP:0001799)2.11468103
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.11165508
66Abnormality of the distal phalanx of the thumb (HP:0009617)2.10980495
67Mitral regurgitation (HP:0001653)2.10235629
68Myopathic facies (HP:0002058)2.09453984
69Progressive muscle weakness (HP:0003323)2.09307967
70Abnormality of skeletal muscle fiber size (HP:0012084)2.09173927
71Abnormality of the distal phalanges of the toes (HP:0010182)2.08967314
72Lymphoma (HP:0002665)2.08182776
73Bicuspid aortic valve (HP:0001647)2.07747207
74Difficulty climbing stairs (HP:0003551)2.05466893
75Carpal bone hypoplasia (HP:0001498)2.03173483
76Lymphopenia (HP:0001888)2.02042541
77Hyperparathyroidism (HP:0000843)2.01190093
78Missing ribs (HP:0000921)1.99529004
79Turricephaly (HP:0000262)1.99510132
80Biconcave vertebral bodies (HP:0004586)1.96009797
81Protrusio acetabuli (HP:0003179)1.95908923
82Hand muscle atrophy (HP:0009130)1.95447881
83Cellulitis (HP:0100658)1.95302733
84Medulloblastoma (HP:0002885)1.95294751
85Cerebral inclusion bodies (HP:0100314)1.93600839
86Broad palm (HP:0001169)1.91942035
87Abnormality of the thoracic spine (HP:0100711)1.90922685
88Deep palmar crease (HP:0006191)1.89719985
89Ankyloglossia (HP:0010296)1.89694109
90Reticulocytosis (HP:0001923)1.89663570
91Pointed chin (HP:0000307)1.89179165
92Premature skin wrinkling (HP:0100678)1.88789357
93Cervical subluxation (HP:0003308)1.88249199
94Mildly elevated creatine phosphokinase (HP:0008180)1.88236398
95Bronchitis (HP:0012387)1.88172918
96Increased density of long bones (HP:0006392)1.87995351
97Fatigue (HP:0012378)1.87872846
98Patellar dislocation (HP:0002999)1.87651571
99Truncus arteriosus (HP:0001660)1.87315031
100Abnormality of the calcaneus (HP:0008364)1.86628782
101Genu recurvatum (HP:0002816)1.85751832
102Ulnar deviation of the wrist (HP:0003049)1.85259115
103Asymmetry of the thorax (HP:0001555)1.84999484
104Rough bone trabeculation (HP:0100670)1.83989761
105Abnormality of the fingertips (HP:0001211)1.83881233
106Polygenic inheritance (HP:0010982)1.83741492
107Thin bony cortex (HP:0002753)1.83171678
108Aortic aneurysm (HP:0004942)1.82478675
109Neoplasm of the rectum (HP:0100743)1.81573744
110Blue sclerae (HP:0000592)1.80798744
111Trismus (HP:0000211)1.80524788
112Poikiloderma (HP:0001029)1.80350449
113Overriding aorta (HP:0002623)1.80141675
114Radial bowing (HP:0002986)1.79743308
115Cerebral aneurysm (HP:0004944)1.79262412
116Adenoma sebaceum (HP:0009720)1.79189733
117Angiofibromas (HP:0010615)1.79189733
118Severe short stature (HP:0003510)1.78801712
119Abnormal gallbladder physiology (HP:0012438)1.78670380
120Cholecystitis (HP:0001082)1.78670380
121Back pain (HP:0003418)1.78417840
122Agammaglobulinemia (HP:0004432)1.76492063
123Hemorrhage of the eye (HP:0011885)1.75794942
124Abnormality of oral frenula (HP:0000190)1.75032361
125Abnormal protein glycosylation (HP:0012346)1.74938742
126Abnormal glycosylation (HP:0012345)1.74938742
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74938742
128Abnormal protein N-linked glycosylation (HP:0012347)1.74938742
129Generalized amyotrophy (HP:0003700)1.74564675
130Biliary tract neoplasm (HP:0100574)1.74041751
131Ragged-red muscle fibers (HP:0003200)1.73791637
132Papilloma (HP:0012740)1.73199420
133Verrucae (HP:0200043)1.73199420
134Chest pain (HP:0100749)1.72983293
135Hypertensive crisis (HP:0100735)1.72792631
136Ankle contracture (HP:0006466)1.72188384
137Elbow flexion contracture (HP:0002987)1.71933682
138Renal duplication (HP:0000075)1.70881464
139Myelodysplasia (HP:0002863)1.69948548
140Elfin facies (HP:0004428)1.68728125
141Abnormal ossification of hand bones (HP:0005921)1.68350272
142Advanced eruption of teeth (HP:0006288)1.67920280
143Type I transferrin isoform profile (HP:0003642)1.67547747
144Recurrent fungal infections (HP:0002841)1.66721850
145Emphysema (HP:0002097)1.65961962
146Atrophy/Degeneration involving motor neurons (HP:0007373)1.65895074
147Abnormality of the peritoneum (HP:0002585)1.65688586
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.65584065
149Osteolytic defects of the hand bones (HP:0009699)1.65584065
150Thin ribs (HP:0000883)1.64977991
151Bladder diverticulum (HP:0000015)1.64271087
152Neoplasm of the small intestine (HP:0100833)1.64170862
153Abnormality of the tricuspid valve (HP:0001702)1.64023425
154Arnold-Chiari malformation (HP:0002308)1.63652129
155Hypercalcemia (HP:0003072)1.63444830
156Abnormality of the phalanges of the hallux (HP:0010057)1.63080470
157Spinal cord lesions (HP:0100561)1.62245788
158Syringomyelia (HP:0003396)1.62245788
159Bulbar palsy (HP:0001283)1.62086970
160Neoplasm of the colon (HP:0100273)1.61671412
161Metaphyseal cupping (HP:0003021)1.61235341
162Gastrointestinal stroma tumor (HP:0100723)1.61091780
163Hyperthyroidism (HP:0000836)1.60585718
164Chronic sinusitis (HP:0011109)1.59113462
165Axonal loss (HP:0003447)1.59106945
166Bowel incontinence (HP:0002607)1.58761727
167Atrophic scars (HP:0001075)1.58473144
168Hypercortisolism (HP:0001578)1.58298991
169Abnormality of reticulocytes (HP:0004312)1.58217681
170Meningitis (HP:0001287)1.57905775
171High pitched voice (HP:0001620)1.57699068
172Dilatation of the ascending aorta (HP:0005111)1.57277681
173Bowed forearm bones (HP:0003956)1.57029961
174Bowing of the arm (HP:0006488)1.57029961
175Spinal cord compression (HP:0002176)1.56947598
176Dysmetric saccades (HP:0000641)1.56903903
177Slender long bone (HP:0003100)1.56811715
178Segmental peripheral demyelination/remyelination (HP:0003481)1.56798181
179Aneurysm (HP:0002617)1.56405901
180Natal tooth (HP:0000695)1.55838697
181J-shaped sella turcica (HP:0002680)1.55753026
182Increased nuchal translucency (HP:0010880)1.54842274
183Prominent nose (HP:0000448)1.53780658
184Nonimmune hydrops fetalis (HP:0001790)1.51476103
185Gastrointestinal carcinoma (HP:0002672)1.50603648
186Malignant gastrointestinal tract tumors (HP:0006749)1.50603648
187IgG deficiency (HP:0004315)1.49218660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.93889925
2EEF2K3.66872570
3BUB13.53435667
4PRPF4B3.31372119
5PKN22.93755552
6IRAK32.85571111
7ICK2.85253953
8MAP4K12.83669109
9PASK2.67661740
10TRIB32.66762873
11MAP3K102.43700057
12WEE12.29213182
13ERN12.20065205
14RPS6KB22.11295612
15TGFBR12.07262962
16LRRK21.98260555
17FLT31.90667571
18TESK21.84001732
19NEK21.82708751
20RPS6KA41.80293691
21ZAP701.75162203
22STK101.71760138
23SCYL21.71574256
24PAK41.69616480
25MAPKAPK31.68686020
26NME21.65624927
27MAP2K31.63643528
28CDC71.62119810
29STK161.61963562
30BTK1.60178012
31ARAF1.58351437
32ACVR1B1.58123298
33TAOK21.45425983
34JAK31.43485440
35KDR1.41060747
36TSSK61.36818095
37MAP3K131.34286999
38PDGFRA1.33843019
39CDK41.33019537
40GRK61.32613924
41PRKD31.31869817
42NEK11.31126764
43TYK21.29458805
44MST1R1.25791201
45DYRK31.24383866
46BLK1.20250103
47KSR21.19209291
48BRAF1.15427318
49LATS21.12691828
50MAP3K81.11087287
51FGFR41.11086270
52PTK61.07089675
53KIT1.05630128
54ATR1.05302997
55NTRK10.99467248
56BCKDK0.99097259
57PIM20.97335958
58MARK20.94563315
59ITK0.93527360
60IRAK20.92612692
61EIF2AK30.92483908
62BMX0.90818024
63TESK10.89781433
64MAP2K20.88750032
65MAP3K10.85268181
66TTN0.84959263
67RPS6KA20.83521824
68MAP3K30.83414196
69MAP3K90.83279255
70NLK0.82924712
71CDC42BPA0.82379226
72TGFBR20.82279833
73TAOK10.81491965
74MAP2K60.78971052
75AURKB0.78917356
76MAP3K110.78799812
77IRAK40.78359898
78PDPK10.77909614
79ILK0.77602842
80TBK10.77501356
81CDK70.77245618
82PRKD20.76269812
83EPHA20.76115982
84TYRO30.75071146
85BRSK20.74624635
86RIPK10.74313209
87SYK0.73622754
88LMTK20.71018019
89RIPK40.70117475
90VRK10.69160156
91EPHB10.67499401
92TEC0.66290573
93FGFR30.65669557
94CSF1R0.65395263
95TXK0.64702258
96PLK10.63077812
97CSK0.62361271
98VRK20.61760069
99MOS0.60648488
100TTK0.59957741
101LCK0.59183617
102PIM10.58276577
103CDK80.56757664
104CAMKK10.55857747
105EIF2AK10.55063655
106MET0.54204891
107ALK0.54029673
108SIK20.53936289
109PAK10.51460122
110HIPK20.51312782
111PRKCI0.49903497
112CAMK1D0.47954298
113CDK120.47891622
114MTOR0.47486962
115MELK0.47259070
116FGFR10.46161472
117MAP3K60.46151270
118BRSK10.46137923
119RPS6KA60.44807757
120MAPK110.44746389
121MAPK120.44599122
122CHEK10.44358422
123RET0.42241223
124DMPK0.42130777
125AKT20.42091942
126PRKG20.40920295
127CDK11A0.40884775
128DAPK30.40230231
129DDR20.39503717
130EPHB20.39301569
131AURKA0.39295668
132LIMK10.39154592
133JAK10.38970947
134ABL20.38558926
135CDK150.36997118
136PAK20.36312652
137MATK0.36009984
138LYN0.35203416
139HCK0.34820942
140DAPK10.34659940
141CDK20.34106575
142PDK10.33804719
143RAF10.33762449
144CDK60.33743587
145STK40.33050785
146DYRK1B0.33032313
147RPS6KL10.32420291
148RPS6KC10.32420291
149CDK90.32240534
150PTK20.32042955
151MAPKAPK20.31599067
152RPS6KA10.31040849
153SIK10.31004796

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.03933716
2Ribosome_Homo sapiens_hsa030103.81324522
3Mismatch repair_Homo sapiens_hsa034303.32831581
4Spliceosome_Homo sapiens_hsa030402.78816468
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74125004
6Base excision repair_Homo sapiens_hsa034102.62964311
7Proteasome_Homo sapiens_hsa030502.47362481
8Primary immunodeficiency_Homo sapiens_hsa053402.44164918
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21357769
10RNA transport_Homo sapiens_hsa030132.16397946
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.11980210
12RNA polymerase_Homo sapiens_hsa030202.02759798
13Cell cycle_Homo sapiens_hsa041101.94806546
14Antigen processing and presentation_Homo sapiens_hsa046121.92362559
15Nucleotide excision repair_Homo sapiens_hsa034201.86900522
16Pyrimidine metabolism_Homo sapiens_hsa002401.84645728
17Homologous recombination_Homo sapiens_hsa034401.71230243
18Prion diseases_Homo sapiens_hsa050201.68682003
19One carbon pool by folate_Homo sapiens_hsa006701.65050483
20Selenocompound metabolism_Homo sapiens_hsa004501.65010651
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62041821
22Glioma_Homo sapiens_hsa052141.42215329
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.38906034
24p53 signaling pathway_Homo sapiens_hsa041151.37321945
25Pentose phosphate pathway_Homo sapiens_hsa000301.34368580
26RNA degradation_Homo sapiens_hsa030181.31264666
27Epstein-Barr virus infection_Homo sapiens_hsa051691.28385862
28Renal cell carcinoma_Homo sapiens_hsa052111.26122849
29N-Glycan biosynthesis_Homo sapiens_hsa005101.24465443
30Thyroid hormone signaling pathway_Homo sapiens_hsa049191.23416159
31ErbB signaling pathway_Homo sapiens_hsa040121.21433680
32Herpes simplex infection_Homo sapiens_hsa051681.21126388
33B cell receptor signaling pathway_Homo sapiens_hsa046621.19911699
34Thyroid cancer_Homo sapiens_hsa052161.18685872
35Insulin signaling pathway_Homo sapiens_hsa049101.18346640
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15126684
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09749507
38Viral carcinogenesis_Homo sapiens_hsa052031.09210783
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08539617
40Sulfur relay system_Homo sapiens_hsa041221.07538204
41Focal adhesion_Homo sapiens_hsa045101.07327698
42Non-homologous end-joining_Homo sapiens_hsa034501.07182041
43HTLV-I infection_Homo sapiens_hsa051661.05796732
44mRNA surveillance pathway_Homo sapiens_hsa030151.05151866
45Acute myeloid leukemia_Homo sapiens_hsa052211.04694798
46Apoptosis_Homo sapiens_hsa042101.03673513
47Proteoglycans in cancer_Homo sapiens_hsa052051.03573155
48Chronic myeloid leukemia_Homo sapiens_hsa052201.01278821
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99529018
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98789955
51Colorectal cancer_Homo sapiens_hsa052100.97290774
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95667052
53Measles_Homo sapiens_hsa051620.93891442
54Legionellosis_Homo sapiens_hsa051340.93429851
55GnRH signaling pathway_Homo sapiens_hsa049120.92874525
56Notch signaling pathway_Homo sapiens_hsa043300.91281977
57AMPK signaling pathway_Homo sapiens_hsa041520.89598336
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.88281275
59Phospholipase D signaling pathway_Homo sapiens_hsa040720.87140734
60T cell receptor signaling pathway_Homo sapiens_hsa046600.86570694
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85348271
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.84840930
63Estrogen signaling pathway_Homo sapiens_hsa049150.84699739
64Shigellosis_Homo sapiens_hsa051310.84398812
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84109194
66Prostate cancer_Homo sapiens_hsa052150.83699278
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.83310701
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82615910
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.81546224
70Endocytosis_Homo sapiens_hsa041440.81196611
71Leishmaniasis_Homo sapiens_hsa051400.80998884
72Galactose metabolism_Homo sapiens_hsa000520.80494797
73Hepatitis B_Homo sapiens_hsa051610.80379754
74Adherens junction_Homo sapiens_hsa045200.79723570
75Other glycan degradation_Homo sapiens_hsa005110.78568038
76Amoebiasis_Homo sapiens_hsa051460.78540875
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.78422948
78Purine metabolism_Homo sapiens_hsa002300.78068957
79Hepatitis C_Homo sapiens_hsa051600.77666005
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77662247
81Vibrio cholerae infection_Homo sapiens_hsa051100.77189643
82Small cell lung cancer_Homo sapiens_hsa052220.75436083
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75414075
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.74656311
85Biosynthesis of amino acids_Homo sapiens_hsa012300.74362553
86Protein export_Homo sapiens_hsa030600.73234459
87Salmonella infection_Homo sapiens_hsa051320.73024262
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71902445
89Choline metabolism in cancer_Homo sapiens_hsa052310.71568351
90Viral myocarditis_Homo sapiens_hsa054160.71500969
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71411446
92Long-term potentiation_Homo sapiens_hsa047200.71155603
93Inositol phosphate metabolism_Homo sapiens_hsa005620.70828209
94Fanconi anemia pathway_Homo sapiens_hsa034600.70577917
95Vitamin B6 metabolism_Homo sapiens_hsa007500.69416618
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68390507
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.67367231
98Hematopoietic cell lineage_Homo sapiens_hsa046400.67242479
99Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67223061
100Toxoplasmosis_Homo sapiens_hsa051450.66572722
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66179277
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66081144
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.66028259
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.65316536
105Prolactin signaling pathway_Homo sapiens_hsa049170.64204147
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64010324
107Bladder cancer_Homo sapiens_hsa052190.63548604
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63176336
109Melanogenesis_Homo sapiens_hsa049160.62500769
110Influenza A_Homo sapiens_hsa051640.62258513
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62095382
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.61633440
113Basal transcription factors_Homo sapiens_hsa030220.61280519
114Folate biosynthesis_Homo sapiens_hsa007900.61217317
115Lysosome_Homo sapiens_hsa041420.60805038
116Pancreatic cancer_Homo sapiens_hsa052120.60086247
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60058581
118mTOR signaling pathway_Homo sapiens_hsa041500.58967450
119Carbon metabolism_Homo sapiens_hsa012000.57821863
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.57787046
121VEGF signaling pathway_Homo sapiens_hsa043700.56867030
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56301689
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.56032296
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55144111
125Melanoma_Homo sapiens_hsa052180.54489622
126Osteoclast differentiation_Homo sapiens_hsa043800.54107239
127HIF-1 signaling pathway_Homo sapiens_hsa040660.53328466
128Pathways in cancer_Homo sapiens_hsa052000.53190457
129ECM-receptor interaction_Homo sapiens_hsa045120.53171290
130Rap1 signaling pathway_Homo sapiens_hsa040150.52775580
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52473672
132Basal cell carcinoma_Homo sapiens_hsa052170.52145917
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.50091437
134Lysine degradation_Homo sapiens_hsa003100.49440641
135Non-small cell lung cancer_Homo sapiens_hsa052230.48251521
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46883619
137Fructose and mannose metabolism_Homo sapiens_hsa000510.46381471
138Platelet activation_Homo sapiens_hsa046110.45925714
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.44741781
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43231429
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43153127
142Insulin resistance_Homo sapiens_hsa049310.39080169
143RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38724900
144Endometrial cancer_Homo sapiens_hsa052130.37657116
145Oocyte meiosis_Homo sapiens_hsa041140.37340851
146Glycosaminoglycan degradation_Homo sapiens_hsa005310.34833945
147MicroRNAs in cancer_Homo sapiens_hsa052060.34781862

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