NELFCD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.30520212
2DNA unwinding involved in DNA replication (GO:0006268)5.10748021
3DNA strand elongation (GO:0022616)5.03161840
4COPI coating of Golgi vesicle (GO:0048205)4.92700184
5Golgi transport vesicle coating (GO:0048200)4.92700184
6telomere maintenance via semi-conservative replication (GO:0032201)4.87132202
7DNA replication initiation (GO:0006270)4.74076387
8nucleobase biosynthetic process (GO:0046112)4.67155848
9purine nucleobase biosynthetic process (GO:0009113)4.57776735
10DNA replication checkpoint (GO:0000076)4.49966915
11mitotic recombination (GO:0006312)4.38554250
12telomere maintenance via recombination (GO:0000722)4.32511929
13proline biosynthetic process (GO:0006561)4.22988112
14spliceosomal tri-snRNP complex assembly (GO:0000244)4.21083033
15kinetochore organization (GO:0051383)4.20177152
16mitotic metaphase plate congression (GO:0007080)4.19912101
17protein localization to kinetochore (GO:0034501)4.11984571
18kinetochore assembly (GO:0051382)4.07737048
19GDP-mannose metabolic process (GO:0019673)4.07588984
20DNA replication-dependent nucleosome assembly (GO:0006335)4.05613075
21DNA replication-dependent nucleosome organization (GO:0034723)4.05613075
22mitotic sister chromatid segregation (GO:0000070)3.89933638
23formation of translation preinitiation complex (GO:0001731)3.88800775
24telomere maintenance via telomere lengthening (GO:0010833)3.83481788
25cullin deneddylation (GO:0010388)3.80641240
26nucleotide-excision repair, DNA gap filling (GO:0006297)3.79393139
27IMP biosynthetic process (GO:0006188)3.72759097
28regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.70573600
29metaphase plate congression (GO:0051310)3.70340999
30CENP-A containing nucleosome assembly (GO:0034080)3.69919643
31mitotic nuclear envelope disassembly (GO:0007077)3.67455543
32DNA replication-independent nucleosome assembly (GO:0006336)3.65322247
33DNA replication-independent nucleosome organization (GO:0034724)3.65322247
34DNA deamination (GO:0045006)3.62742157
35chromatin remodeling at centromere (GO:0031055)3.62309190
36mitotic chromosome condensation (GO:0007076)3.60520911
37protein deneddylation (GO:0000338)3.60228047
38protein localization to chromosome, centromeric region (GO:0071459)3.59666252
39peptidyl-arginine N-methylation (GO:0035246)3.56673366
40peptidyl-arginine methylation (GO:0018216)3.56673366
41sister chromatid segregation (GO:0000819)3.54701148
42histone H2A acetylation (GO:0043968)3.54585599
43postreplication repair (GO:0006301)3.51208550
44attachment of spindle microtubules to kinetochore (GO:0008608)3.49776246
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.49387506
46regulation of translational fidelity (GO:0006450)3.47665048
47establishment of chromosome localization (GO:0051303)3.46177143
48somatic diversification of immune receptors via somatic mutation (GO:0002566)3.45981492
49somatic hypermutation of immunoglobulin genes (GO:0016446)3.45981492
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.44829741
51spliceosomal snRNP assembly (GO:0000387)3.40255295
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39217055
53nuclear envelope disassembly (GO:0051081)3.35675941
54membrane disassembly (GO:0030397)3.35675941
55ribosome biogenesis (GO:0042254)3.34047640
56ribosomal small subunit assembly (GO:0000028)3.33861451
57folic acid-containing compound biosynthetic process (GO:0009396)3.33200458
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30882253
59nuclear pore complex assembly (GO:0051292)3.30871417
60establishment of integrated proviral latency (GO:0075713)3.30625133
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27746621
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.26074385
63peptidyl-arginine omega-N-methylation (GO:0035247)3.25745517
64positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.24756773
65transcription-coupled nucleotide-excision repair (GO:0006283)3.24171058
66nuclear pore organization (GO:0006999)3.24026784
67DNA topological change (GO:0006265)3.23346093
68folic acid metabolic process (GO:0046655)3.23279101
69negative regulation of chromosome segregation (GO:0051985)3.17730669
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16361163
71negative regulation of sister chromatid segregation (GO:0033046)3.16361163
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.16361163
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16361163
74translesion synthesis (GO:0019985)3.13879988
75histone exchange (GO:0043486)3.13754464
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10669958
77RNA splicing, via transesterification reactions (GO:0000375)3.10476731
78viral mRNA export from host cell nucleus (GO:0046784)3.10320966
79RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.10031072
80mRNA splicing, via spliceosome (GO:0000398)3.10031072
81spliceosomal complex assembly (GO:0000245)3.09849640
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09574646
83negative regulation of ligase activity (GO:0051352)3.09574646
84maturation of SSU-rRNA (GO:0030490)3.09435301
85negative regulation of RNA splicing (GO:0033119)3.09158742
86spindle assembly checkpoint (GO:0071173)3.08880147
87mitotic spindle assembly checkpoint (GO:0007094)3.08824440
88histone arginine methylation (GO:0034969)3.08459590
89proline metabolic process (GO:0006560)3.07911709
90regulation of mitotic spindle organization (GO:0060236)3.07857126
91regulation of spindle organization (GO:0090224)3.06940981
92IMP metabolic process (GO:0046040)3.06347124
93DNA duplex unwinding (GO:0032508)3.06006800
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05274948
95protein retention in ER lumen (GO:0006621)3.05038652
96proteasome assembly (GO:0043248)3.04928886
97DNA geometric change (GO:0032392)3.04433723
98hepatocyte apoptotic process (GO:0097284)3.04335191
99spindle checkpoint (GO:0031577)3.03557116
100mismatch repair (GO:0006298)3.03259877
101regulation of chromosome segregation (GO:0051983)3.03038975
102cell cycle G1/S phase transition (GO:0044843)2.98558246
103G1/S transition of mitotic cell cycle (GO:0000082)2.98558246
104ATP-dependent chromatin remodeling (GO:0043044)2.97612155
105telomere organization (GO:0032200)2.97426828
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96391402
107telomere maintenance (GO:0000723)2.96369207
108melanin biosynthetic process (GO:0042438)2.96283059
109base-excision repair (GO:0006284)2.96126125
110signal transduction involved in DNA damage checkpoint (GO:0072422)2.95513586
111signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95513586
112chromosome segregation (GO:0007059)2.94462463
113positive regulation of chromosome segregation (GO:0051984)2.94369401
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.94274112
115intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.94274112
116mitotic cell cycle (GO:0000278)2.94214308
117DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93143509
118protein maturation by protein folding (GO:0022417)2.92567738
119signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91887539
120signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91887539
121signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91887539
122retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91732490
123negative regulation of histone methylation (GO:0031061)2.91375625
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90910598
125tRNA methylation (GO:0030488)2.90814685
126mitotic spindle checkpoint (GO:0071174)2.90470693
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.89821509
128regulation of cellular amino acid metabolic process (GO:0006521)2.89021825
129ribosome assembly (GO:0042255)2.88670187
130regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88278639
131rRNA transcription (GO:0009303)2.87663259
132regulation of mammary gland epithelial cell proliferation (GO:0033599)2.86173799
133deoxyribonucleotide biosynthetic process (GO:0009263)2.85459375
134positive regulation of keratinocyte differentiation (GO:0045618)2.85445563
135chromatin assembly or disassembly (GO:0006333)2.85267848
136biotin metabolic process (GO:0006768)2.84921692
137snRNA metabolic process (GO:0016073)2.84446659
138nucleobase-containing small molecule interconversion (GO:0015949)2.83353176
139pore complex assembly (GO:0046931)2.82313918
140regulation of mitochondrial translation (GO:0070129)2.82190756
141DNA conformation change (GO:0071103)2.75607094
142negative regulation of mRNA processing (GO:0050686)2.74531855
143glucose catabolic process (GO:0006007)2.73211608
144rRNA modification (GO:0000154)2.72247212
145pseudouridine synthesis (GO:0001522)2.70109826
146regulation of histone H3-K27 methylation (GO:0061085)2.69967621
147snRNA processing (GO:0016180)2.67523495
148melanin metabolic process (GO:0006582)2.67506246
149tRNA aminoacylation for protein translation (GO:0006418)2.66590952
150pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.66170287
151positive regulation of DNA-dependent DNA replication (GO:2000105)2.62884734
152meiotic chromosome segregation (GO:0045132)2.62466516
153chromosome condensation (GO:0030261)2.61260818
154amino acid activation (GO:0043038)2.57815899
155tRNA aminoacylation (GO:0043039)2.57815899
156negative regulation of cell size (GO:0045792)2.57603223
157positive regulation of ligase activity (GO:0051351)2.54677914
158pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.53788871
159pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.52833494
160regulation of translational termination (GO:0006449)2.52075537
161nuclear envelope organization (GO:0006998)2.50369768
162protein-DNA complex disassembly (GO:0032986)2.47147327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.85352428
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.32967993
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98022747
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.78560709
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.58185424
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31636556
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.16203009
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06532367
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.97083327
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92605806
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.77916164
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77725005
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76451303
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67970741
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.64301821
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.63265784
17XRN2_22483619_ChIP-Seq_HELA_Human2.48007857
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.37930488
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37894545
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28404781
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27442496
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16535811
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14101614
24VDR_23849224_ChIP-Seq_CD4+_Human2.07620137
25FOXP3_21729870_ChIP-Seq_TREG_Human2.05696789
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.03079830
27AR_21909140_ChIP-Seq_LNCAP_Human2.02272685
28CIITA_25753668_ChIP-Seq_RAJI_Human2.02132747
29ZNF263_19887448_ChIP-Seq_K562_Human1.99192811
30GABP_19822575_ChIP-Seq_HepG2_Human1.94598627
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.93300342
32DCP1A_22483619_ChIP-Seq_HELA_Human1.88763944
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88763722
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.87448796
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.86109214
36YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85028122
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78713748
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.77422548
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76525778
40MYC_22102868_ChIP-Seq_BL_Human1.76040124
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72165980
42TTF2_22483619_ChIP-Seq_HELA_Human1.69773422
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.68000040
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.67506822
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64264005
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64048109
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63933476
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61224153
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58902663
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.55212031
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52903028
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51024315
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.50680609
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48520712
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.47102347
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47011852
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46906693
58RACK7_27058665_Chip-Seq_MCF-7_Human1.45160939
59KDM5A_27292631_Chip-Seq_BREAST_Human1.44860538
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41631755
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41583635
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39034457
63CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35875836
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.30132896
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.28487440
66CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25800595
67ELK1_19687146_ChIP-ChIP_HELA_Human1.24627480
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24132531
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23231204
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21671551
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21057673
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19088410
73SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19037220
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18585645
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18374376
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17457359
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16207945
78VDR_21846776_ChIP-Seq_THP-1_Human1.16153769
79P68_20966046_ChIP-Seq_HELA_Human1.16081124
80LXR_22292898_ChIP-Seq_THP-1_Human1.15342366
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15165174
82KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13475836
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13269220
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12085593
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10897337
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10036398
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09442508
88FOXP1_21924763_ChIP-Seq_HESCs_Human1.06298011
89PKCTHETA_26484144_Chip-Seq_BREAST_Human1.06286264
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06224251
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05763622
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.05723264
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04281854
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03762424
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03593756
96TFEB_21752829_ChIP-Seq_HELA_Human1.02456634
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01811686
98RARB_24833708_ChIP-Seq_LIVER_Mouse1.01343426
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.01191581
100ESR1_21235772_ChIP-Seq_MCF-7_Human1.00453736
101ELK3_25401928_ChIP-Seq_HUVEC_Human1.00447403
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00303170
103ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99239119
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98805681
105ESR2_21235772_ChIP-Seq_MCF-7_Human0.98124408
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95826303
107MYC_18940864_ChIP-ChIP_HL60_Human0.92096056
108CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91969967
109CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.90096951
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89315761
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89193576
112SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.89191787
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88255687
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87684316
115CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86840035
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85931411
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84907742
118OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83455462
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.81593358
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78063766
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77539856
122SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76351402

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.01848319
2MP0010094_abnormal_chromosome_stability4.97848476
3MP0003111_abnormal_nucleus_morphology4.76517512
4MP0003077_abnormal_cell_cycle4.38222184
5MP0004957_abnormal_blastocyst_morpholog4.14527032
6MP0008058_abnormal_DNA_repair3.71572533
7MP0008057_abnormal_DNA_replication3.67785296
8MP0008007_abnormal_cellular_replicative3.40210155
9MP0003123_paternal_imprinting3.09007394
10MP0000372_irregular_coat_pigmentation2.87610963
11MP0008932_abnormal_embryonic_tissue2.77156010
12MP0001730_embryonic_growth_arrest2.61183486
13MP0008877_abnormal_DNA_methylation2.59508079
14MP0004233_abnormal_muscle_weight2.57894031
15MP0005451_abnormal_body_composition2.50507589
16MP0002653_abnormal_ependyma_morphology2.49618087
17MP0010030_abnormal_orbit_morphology2.45435993
18MP0005083_abnormal_biliary_tract2.39674658
19MP0005408_hypopigmentation2.37333146
20MP0005257_abnormal_intraocular_pressure2.36869198
21MP0005171_absent_coat_pigmentation2.28905669
22MP0002396_abnormal_hematopoietic_system2.26613644
23MP0005075_abnormal_melanosome_morpholog2.23924203
24MP0000350_abnormal_cell_proliferation2.23814926
25MP0004381_abnormal_hair_follicle2.21405293
26MP0002877_abnormal_melanocyte_morpholog1.89889546
27MP0003121_genomic_imprinting1.85301445
28MP0001672_abnormal_embryogenesis/_devel1.84397098
29MP0005380_embryogenesis_phenotype1.84397098
30MP0005058_abnormal_lysosome_morphology1.84292164
31MP0001697_abnormal_embryo_size1.82874993
32MP0003786_premature_aging1.79528326
33MP0004264_abnormal_extraembryonic_tissu1.78742029
34MP0002080_prenatal_lethality1.74814859
35MP0003984_embryonic_growth_retardation1.67174071
36MP0002088_abnormal_embryonic_growth/wei1.64446062
37MP0003567_abnormal_fetal_cardiomyocyte1.63454975
38MP0000313_abnormal_cell_death1.58369795
39MP0002085_abnormal_embryonic_tissue1.58051178
40MP0003806_abnormal_nucleotide_metabolis1.56835512
41MP0003136_yellow_coat_color1.49402992
42MP0002084_abnormal_developmental_patter1.48746470
43MP0004197_abnormal_fetal_growth/weight/1.47404356
44MP0008260_abnormal_autophagy1.45318045
45MP0005501_abnormal_skin_physiology1.45260429
46MP0001346_abnormal_lacrimal_gland1.44571347
47MP0000371_diluted_coat_color1.44455668
48MP0004133_heterotaxia1.39405985
49MP0003656_abnormal_erythrocyte_physiolo1.39106263
50MP0000566_synostosis1.37943697
51MP0010307_abnormal_tumor_latency1.36719549
52MP0004808_abnormal_hematopoietic_stem1.33843232
53MP0001661_extended_life_span1.33207175
54MP0000003_abnormal_adipose_tissue1.32547699
55MP0002075_abnormal_coat/hair_pigmentati1.30904145
56MP0000490_abnormal_crypts_of1.29687750
57MP0003122_maternal_imprinting1.28514362
58MP0008789_abnormal_olfactory_epithelium1.28170025
59MP0008875_abnormal_xenobiotic_pharmacok1.27101127
60MP0002019_abnormal_tumor_incidence1.26962593
61MP0009672_abnormal_birth_weight1.26307569
62MP0002086_abnormal_extraembryonic_tissu1.25303695
63MP0002132_abnormal_respiratory_system1.25077376
64MP0001186_pigmentation_phenotype1.25020959
65MP0002098_abnormal_vibrissa_morphology1.24017526
66MP0003943_abnormal_hepatobiliary_system1.23695460
67MP0006292_abnormal_olfactory_placode1.23360761
68MP0003119_abnormal_digestive_system1.22806272
69MP0004147_increased_porphyrin_level1.22420831
70MP0003221_abnormal_cardiomyocyte_apopto1.22397639
71MP0006036_abnormal_mitochondrial_physio1.18177940
72MP0003890_abnormal_embryonic-extraembry1.18018054
73MP0000537_abnormal_urethra_morphology1.15069971
74MP0009053_abnormal_anal_canal1.14627704
75MP0001529_abnormal_vocalization1.13745992
76MP0009333_abnormal_splenocyte_physiolog1.12937817
77MP0002210_abnormal_sex_determination1.12887338
78MP0008995_early_reproductive_senescence1.12568325
79MP0010352_gastrointestinal_tract_polyps1.11496468
80MP0002751_abnormal_autonomic_nervous1.11331559
81MP0003718_maternal_effect1.09460361
82MP0002089_abnormal_postnatal_growth/wei1.09161625
83MP0001348_abnormal_lacrimal_gland1.05869729
84MP0000703_abnormal_thymus_morphology1.03914557
85MP0000358_abnormal_cell_content/1.03320349
86MP0010234_abnormal_vibrissa_follicle1.02979172
87MP0000049_abnormal_middle_ear1.01437639
88MP0001873_stomach_inflammation1.00333188
89MP0001293_anophthalmia1.00106500
90MP0005397_hematopoietic_system_phenotyp0.96804941
91MP0001545_abnormal_hematopoietic_system0.96804941
92MP0000015_abnormal_ear_pigmentation0.94363497
93MP0006035_abnormal_mitochondrial_morpho0.94323067
94MP0002398_abnormal_bone_marrow0.93610898
95MP0001849_ear_inflammation0.93287221
96MP0009703_decreased_birth_body0.92568915
97MP0009840_abnormal_foam_cell0.92369105
98MP0005394_taste/olfaction_phenotype0.90728415
99MP0005499_abnormal_olfactory_system0.90728415
100MP0002009_preneoplasia0.89088856
101MP0003315_abnormal_perineum_morphology0.87963803
102MP0002796_impaired_skin_barrier0.87293844
103MP0003763_abnormal_thymus_physiology0.86224543
104MP0002722_abnormal_immune_system0.85160614
105MP0002249_abnormal_larynx_morphology0.85139557
106MP0001145_abnormal_male_reproductive0.83749682
107MP0003787_abnormal_imprinting0.82860421
108MP0002111_abnormal_tail_morphology0.82617512
109MP0000689_abnormal_spleen_morphology0.82388449
110MP0002970_abnormal_white_adipose0.82289179
111MP0001929_abnormal_gametogenesis0.81536522
112MP0000377_abnormal_hair_follicle0.79937244
113MP0005409_darkened_coat_color0.79062562
114MP0009697_abnormal_copulation0.78731387
115MP0002909_abnormal_adrenal_gland0.77858324
116MP0000627_abnormal_mammary_gland0.76343899
117MP0002160_abnormal_reproductive_system0.76281808
118MP0002638_abnormal_pupillary_reflex0.76238529
119MP0000609_abnormal_liver_physiology0.75677115
120MP0000598_abnormal_liver_morphology0.75399049
121MP0005384_cellular_phenotype0.74206837
122MP0004185_abnormal_adipocyte_glucose0.73786912
123MP0000383_abnormal_hair_follicle0.73676434
124MP0000653_abnormal_sex_gland0.73545498
125MP0001119_abnormal_female_reproductive0.72676103
126MP0001727_abnormal_embryo_implantation0.71751588
127MP0000613_abnormal_salivary_gland0.71665119
128MP0006054_spinal_hemorrhage0.70482835
129MP0003942_abnormal_urinary_system0.70305422
130MP0001919_abnormal_reproductive_system0.70005116
131MP0002429_abnormal_blood_cell0.69481729
132MP0003861_abnormal_nervous_system0.68443731
133MP0002269_muscular_atrophy0.67602981
134MP0005076_abnormal_cell_differentiation0.66928481
135MP0003186_abnormal_redox_activity0.65210479
136MP0003115_abnormal_respiratory_system0.65016237
137MP0005266_abnormal_metabolism0.64245714
138MP0003183_abnormal_peptide_metabolism0.62891505
139MP0002092_abnormal_eye_morphology0.61321741
140MP0002938_white_spotting0.59669967
141MP0003937_abnormal_limbs/digits/tail_de0.59034116
142MP0002102_abnormal_ear_morphology0.57123767
143MP0004084_abnormal_cardiac_muscle0.57119253
144MP0001764_abnormal_homeostasis0.56079142
145MP0005621_abnormal_cell_physiology0.54693931

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.78546698
2Degeneration of anterior horn cells (HP:0002398)4.27829688
3Abnormality of the anterior horn cell (HP:0006802)4.27829688
4Microvesicular hepatic steatosis (HP:0001414)3.94317812
5Patellar aplasia (HP:0006443)3.86981930
6Testicular atrophy (HP:0000029)3.67128705
7Cerebral hypomyelination (HP:0006808)3.63155893
8Aplasia/Hypoplasia of the patella (HP:0006498)3.58396198
9Cholecystitis (HP:0001082)3.41200057
10Abnormal gallbladder physiology (HP:0012438)3.41200057
11Selective tooth agenesis (HP:0001592)3.36539053
12Medulloblastoma (HP:0002885)3.32131412
13Septate vagina (HP:0001153)3.29877302
14Abnormal number of incisors (HP:0011064)3.25816810
15Poikiloderma (HP:0001029)3.20229045
16J-shaped sella turcica (HP:0002680)3.19731925
17Meckel diverticulum (HP:0002245)3.18930254
18Ependymoma (HP:0002888)3.14816350
19Abnormality of the ileum (HP:0001549)3.14734574
20Oral leukoplakia (HP:0002745)3.13452408
21Aplasia/Hypoplasia of the uvula (HP:0010293)3.05405329
22Abnormality of the preputium (HP:0100587)3.02284618
23Type I transferrin isoform profile (HP:0003642)3.02168923
24Colon cancer (HP:0003003)3.01600006
25Increased serum pyruvate (HP:0003542)2.97355720
26Abnormality of glycolysis (HP:0004366)2.97355720
27Abnormality of chromosome stability (HP:0003220)2.91539309
28Reduced antithrombin III activity (HP:0001976)2.89022162
29Asymmetry of the thorax (HP:0001555)2.86544476
30Increased nuchal translucency (HP:0010880)2.82099196
31Atrophy/Degeneration involving motor neurons (HP:0007373)2.80074403
32Breast hypoplasia (HP:0003187)2.79582782
33Chromsome breakage (HP:0040012)2.75566347
34Hypokinesia (HP:0002375)2.72807830
35Progressive muscle weakness (HP:0003323)2.71750462
36Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69110669
37Reticulocytopenia (HP:0001896)2.58414356
38Duodenal stenosis (HP:0100867)2.57743017
39Small intestinal stenosis (HP:0012848)2.57743017
40Agnosia (HP:0010524)2.57506713
41Proximal placement of thumb (HP:0009623)2.55002863
42Abnormality of the heme biosynthetic pathway (HP:0010472)2.54758426
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.54166103
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.52839804
45Abnormal protein N-linked glycosylation (HP:0012347)2.52839804
46Abnormal protein glycosylation (HP:0012346)2.52839804
47Abnormal glycosylation (HP:0012345)2.52839804
48Concave nail (HP:0001598)2.52608724
49Trismus (HP:0000211)2.52531243
50Absent epiphyses (HP:0010577)2.47055759
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.47055759
52Microretrognathia (HP:0000308)2.42998620
53Optic nerve coloboma (HP:0000588)2.42741656
54Microglossia (HP:0000171)2.41873617
55Seborrheic dermatitis (HP:0001051)2.41557424
56Cholelithiasis (HP:0001081)2.41364619
57Impulsivity (HP:0100710)2.39649199
58Entropion (HP:0000621)2.38287049
59Hypoparathyroidism (HP:0000829)2.37220106
60Prolonged partial thromboplastin time (HP:0003645)2.36465774
61Rhabdomyosarcoma (HP:0002859)2.35389330
62Absent thumb (HP:0009777)2.35128369
63Abnormal lung lobation (HP:0002101)2.34978805
64Myelodysplasia (HP:0002863)2.34867501
65Deviation of the thumb (HP:0009603)2.34553730
66Multiple enchondromatosis (HP:0005701)2.33519803
67Reticulocytosis (HP:0001923)2.33166937
68Micronodular cirrhosis (HP:0001413)2.30299558
69Bone marrow hypocellularity (HP:0005528)2.30160482
70Increased serum lactate (HP:0002151)2.29593938
71Hyperacusis (HP:0010780)2.27950802
72Abnormality of the carotid arteries (HP:0005344)2.27928805
73Deep venous thrombosis (HP:0002625)2.27470198
74Abnormality of pyrimidine metabolism (HP:0004353)2.23155635
75Slender long bone (HP:0003100)2.21966350
76Prominent metopic ridge (HP:0005487)2.19625607
77Sloping forehead (HP:0000340)2.19033212
78Abnormality of the duodenum (HP:0002246)2.16533008
79Squamous cell carcinoma (HP:0002860)2.16282521
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16164416
81Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16164416
8211 pairs of ribs (HP:0000878)2.16127581
83Neoplasm of the pancreas (HP:0002894)2.15613880
84Atresia of the external auditory canal (HP:0000413)2.15147979
85Abnormality of the labia minora (HP:0012880)2.13826899
86Hypoplasia of the pons (HP:0012110)2.13099526
87Abnormal number of erythroid precursors (HP:0012131)2.12615431
88Absent radius (HP:0003974)2.11991145
89Astrocytoma (HP:0009592)2.11518691
90Abnormality of the astrocytes (HP:0100707)2.11518691
91Opisthotonus (HP:0002179)2.11209520
92Respiratory difficulties (HP:0002880)2.10814586
93Cutaneous melanoma (HP:0012056)2.07979997
94Broad alveolar ridges (HP:0000187)2.07955064
95Hyperthyroidism (HP:0000836)2.07491111
96Cafe-au-lait spot (HP:0000957)2.05632138
97Glioma (HP:0009733)2.05570762
98Hepatocellular necrosis (HP:0001404)2.05436919
99Aplastic anemia (HP:0001915)2.05369911
100Abnormal gallbladder morphology (HP:0012437)2.05336374
101Premature ovarian failure (HP:0008209)2.03132917
102Abnormal neuron morphology (HP:0012757)2.02443670
103Abnormality of the motor neurons (HP:0002450)2.02443670
104Renal duplication (HP:0000075)2.01800154
105High anterior hairline (HP:0009890)2.01166551
106Abnormality of cells of the erythroid lineage (HP:0012130)2.00443279
107Ulnar bowing (HP:0003031)2.00395410
108Rough bone trabeculation (HP:0100670)1.99267533
109Increased intramyocellular lipid droplets (HP:0012240)1.99063806
110Tracheoesophageal fistula (HP:0002575)1.98517169
111Absent forearm bone (HP:0003953)1.97556524
112Aplasia involving forearm bones (HP:0009822)1.97556524
113Hepatic necrosis (HP:0002605)1.97213143
114Spastic paraparesis (HP:0002313)1.96911561
115Carpal bone hypoplasia (HP:0001498)1.96725257
116Abnormality of the umbilical cord (HP:0010881)1.96339781
117Facial hemangioma (HP:0000329)1.94659185
118Overlapping toe (HP:0001845)1.93554230
119Ragged-red muscle fibers (HP:0003200)1.91741305
120Abnormality of the intervertebral disk (HP:0005108)1.91090465
121Abnormality of DNA repair (HP:0003254)1.90448720
122Mesangial abnormality (HP:0001966)1.89976886
123Horseshoe kidney (HP:0000085)1.88295334
124Melanoma (HP:0002861)1.88006386
125Abnormality of the metopic suture (HP:0005556)1.87701126
126Hyperammonemia (HP:0001987)1.87617260
127Abnormality of the gallbladder (HP:0005264)1.86613505
128Vertebral compression fractures (HP:0002953)1.86517497
129Neoplasm of the colon (HP:0100273)1.86050291
130Small epiphyses (HP:0010585)1.85380883
131Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85219766
132Triphalangeal thumb (HP:0001199)1.82384695
133Cellular immunodeficiency (HP:0005374)1.81959706
134Abnormality of the aortic arch (HP:0012303)1.81938061
135Ectopic kidney (HP:0000086)1.81913232
136Abnormality of the intrinsic pathway (HP:0010989)1.81249774
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.80951273
138Self-mutilation (HP:0000742)1.79058846
139Testicular neoplasm (HP:0010788)1.78437745
140Preauricular skin tag (HP:0000384)1.77006422
141CNS demyelination (HP:0007305)1.76753984
142Cerebellar hypoplasia (HP:0001321)1.76485790
143Deep philtrum (HP:0002002)1.76193731
144Sparse lateral eyebrow (HP:0005338)1.76116307
145Secondary amenorrhea (HP:0000869)1.76085999
146Increased CSF lactate (HP:0002490)1.75017633
147Emotional lability (HP:0000712)1.74908936
148Unsteady gait (HP:0002317)1.74146394
149Hypoplasia of the radius (HP:0002984)1.74022461
150Tongue fasciculations (HP:0001308)1.73744912
151Abnormality of the fetal cardiovascular system (HP:0010948)1.73000000
152Abnormal umbilical cord blood vessels (HP:0011403)1.73000000
153Single umbilical artery (HP:0001195)1.73000000
154CNS hypomyelination (HP:0003429)1.72707336
155Increased muscle lipid content (HP:0009058)1.72428912
156Clubbing of toes (HP:0100760)1.71210786
157Vaginal fistula (HP:0004320)1.71184081
158Abnormality of reticulocytes (HP:0004312)1.71064805
159Abnormality of small intestinal villus morphology (HP:0011472)1.70842483
160Villous atrophy (HP:0011473)1.70842483
161Premature graying of hair (HP:0002216)1.69266688
162Esophageal neoplasm (HP:0100751)1.68911404
163Neoplasm of head and neck (HP:0012288)1.68911404
164Neoplasm of the adrenal gland (HP:0100631)1.66519371
165Abnormal trabecular bone morphology (HP:0100671)1.66469768
166Sparse eyelashes (HP:0000653)1.65665319
167Hypertensive crisis (HP:0100735)1.65326212
168Fasciculations (HP:0002380)1.64908435
169Abnormalities of placenta or umbilical cord (HP:0001194)1.63338015
170Epiphyseal stippling (HP:0010655)1.63009612
171Orthostatic hypotension (HP:0001278)1.61350591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.40386633
2CDC74.61103091
3WEE13.60326409
4NEK13.10208398
5VRK23.06405721
6EPHA23.06333817
7EIF2AK13.03418356
8PASK2.67196521
9TSSK62.62703481
10ACVR1B2.61577820
11NEK22.50550886
12SMG12.46284690
13ICK2.43784197
14IRAK32.28191047
15EEF2K2.21214860
16SRPK12.21026441
17MAP3K102.20147981
18STK162.12243817
19CCNB12.10051447
20SIK12.08133086
21BRSK11.91826984
22PLK11.84201915
23TLK11.75354963
24TTK1.71278136
25BRSK21.68832311
26PLK41.65991930
27PBK1.60137449
28VRK11.59048764
29AURKB1.56166694
30TGFBR11.55454217
31TESK21.55078477
32ATR1.54883624
33PLK31.47250849
34NME11.45433853
35MST1R1.42296211
36AURKA1.36929638
37MKNK11.36740948
38CDK71.36365493
39TRIM281.34579313
40DYRK31.34428991
41CDK81.29078188
42PAK41.28195043
43RPS6KB21.25227963
44SIK31.24940250
45MAP4K11.20062000
46ERN11.19412291
47CDK41.18764142
48NEK61.14373511
49PIM21.13802579
50CHEK21.05242188
51MAPKAPK31.04612817
52CHEK11.03575839
53EIF2AK31.03219979
54BCKDK1.01674451
55MAP2K20.98890933
56RPS6KA40.96700300
57DAPK10.95686215
58PDK20.94857721
59MUSK0.94706908
60STK100.91756101
61MAPK110.90439931
62FGFR40.85361788
63SCYL20.83860903
64KDR0.83044741
65TRIB30.81674883
66FLT30.77167323
67CDK120.77159863
68STK40.76564760
69MAP3K80.75989288
70CDK20.75500433
71RPS6KB10.68671012
72ATM0.67540036
73NME20.67452820
74MTOR0.66679172
75WNK40.63123717
76BRD40.61558567
77CDK10.61548195
78UHMK10.60331373
79BRAF0.57725282
80IRAK20.57613647
81PTK60.57108581
82CSNK2A10.57092158
83DYRK20.56479451
84ZAK0.56382573
85CSNK2A20.55981918
86MET0.55636484
87PAK10.54987926
88ILK0.52363165
89HIPK20.50412900
90MAPKAPK20.49972991
91MELK0.49965794
92LIMK10.49746623
93FGFR10.49663675
94PIK3CA0.48764194
95TESK10.48442571
96YES10.48136689
97CSF1R0.47783326
98AKT20.47398988
99GRK60.46954768
100PDPK10.46420173
101CSNK1G30.45111229
102ZAP700.44692889
103MKNK20.44080537
104PRKD20.43913712
105PDK30.43708184
106PDK40.43708184
107ARAF0.43157300
108BTK0.43055364
109PRKCI0.41997172
110CLK10.41996485
111PKN20.41922981
112CHUK0.41115970
113WNK30.40825176
114PIM10.40381933
115CDK180.38703866
116SIK20.36109494
117MAPK130.35996724
118CDK11A0.35386693
119CDK60.34668512
120LATS10.33537775
121SYK0.33135716
122MAP2K10.32777832
123PTK20.32470406
124EIF2AK20.31786688
125CDK150.31499626
126KSR10.30330930
127TAOK20.30189274
128LRRK20.29903568
129CSNK1A1L0.29589827
130RPS6KA50.29378404
131MYLK0.29263560
132CDK190.28518750
133AKT30.28276745
134CDK140.26237152
135MINK10.25171417
136BCR0.25024909

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.42266782
2Mismatch repair_Homo sapiens_hsa034304.50102196
3Spliceosome_Homo sapiens_hsa030403.50831067
4Base excision repair_Homo sapiens_hsa034103.49932722
5Proteasome_Homo sapiens_hsa030503.48059593
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06938145
7Homologous recombination_Homo sapiens_hsa034402.97866626
8RNA transport_Homo sapiens_hsa030132.93683642
9Nucleotide excision repair_Homo sapiens_hsa034202.93100175
10RNA polymerase_Homo sapiens_hsa030202.90611266
11Cell cycle_Homo sapiens_hsa041102.82253716
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.54176253
13One carbon pool by folate_Homo sapiens_hsa006702.53676617
14Pyrimidine metabolism_Homo sapiens_hsa002402.42015443
15Fanconi anemia pathway_Homo sapiens_hsa034602.24949462
16Ribosome_Homo sapiens_hsa030102.21396028
17Non-homologous end-joining_Homo sapiens_hsa034502.10919583
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.91237226
19mRNA surveillance pathway_Homo sapiens_hsa030151.84769821
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77589455
21Other glycan degradation_Homo sapiens_hsa005111.75989659
22RNA degradation_Homo sapiens_hsa030181.70873451
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65202984
24Biosynthesis of amino acids_Homo sapiens_hsa012301.54098180
25Basal transcription factors_Homo sapiens_hsa030221.53515638
26Steroid biosynthesis_Homo sapiens_hsa001001.40517621
27Fatty acid elongation_Homo sapiens_hsa000621.39842842
28Purine metabolism_Homo sapiens_hsa002301.33684578
29p53 signaling pathway_Homo sapiens_hsa041151.29366783
30Carbon metabolism_Homo sapiens_hsa012001.22046748
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20107840
32Epstein-Barr virus infection_Homo sapiens_hsa051691.18426969
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.17939273
34Vitamin B6 metabolism_Homo sapiens_hsa007501.16142896
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.14461734
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13603272
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.12869626
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.11478754
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05160195
40Oocyte meiosis_Homo sapiens_hsa041141.04491656
41Systemic lupus erythematosus_Homo sapiens_hsa053221.01408995
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.99090788
43Pentose phosphate pathway_Homo sapiens_hsa000300.99034679
44Pyruvate metabolism_Homo sapiens_hsa006200.90166275
45Folate biosynthesis_Homo sapiens_hsa007900.89590747
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84367405
47Selenocompound metabolism_Homo sapiens_hsa004500.83978060
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83687876
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80696709
50Fatty acid metabolism_Homo sapiens_hsa012120.78781714
51Viral carcinogenesis_Homo sapiens_hsa052030.72731169
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69276865
53Tyrosine metabolism_Homo sapiens_hsa003500.69273912
54Herpes simplex infection_Homo sapiens_hsa051680.69047846
55Thyroid cancer_Homo sapiens_hsa052160.65360963
56Notch signaling pathway_Homo sapiens_hsa043300.64297829
57Parkinsons disease_Homo sapiens_hsa050120.59889470
58HTLV-I infection_Homo sapiens_hsa051660.58733468
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.57674102
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57405708
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55660242
62Huntingtons disease_Homo sapiens_hsa050160.54995001
63Sulfur relay system_Homo sapiens_hsa041220.54895899
64Acute myeloid leukemia_Homo sapiens_hsa052210.53321618
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52275460
66Vibrio cholerae infection_Homo sapiens_hsa051100.51758916
67mTOR signaling pathway_Homo sapiens_hsa041500.50046999
68Basal cell carcinoma_Homo sapiens_hsa052170.49606597
69Arginine biosynthesis_Homo sapiens_hsa002200.49284078
70Antigen processing and presentation_Homo sapiens_hsa046120.48755700
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48716691
72Sphingolipid metabolism_Homo sapiens_hsa006000.46688511
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44997336
74N-Glycan biosynthesis_Homo sapiens_hsa005100.43514489
75Lysine degradation_Homo sapiens_hsa003100.41832654
76Glutathione metabolism_Homo sapiens_hsa004800.41626017
77Fructose and mannose metabolism_Homo sapiens_hsa000510.41315977
78Alcoholism_Homo sapiens_hsa050340.40948568
79MicroRNAs in cancer_Homo sapiens_hsa052060.39848302
80Endometrial cancer_Homo sapiens_hsa052130.39512164
81Peroxisome_Homo sapiens_hsa041460.39305590
82AMPK signaling pathway_Homo sapiens_hsa041520.39229725
83Pancreatic cancer_Homo sapiens_hsa052120.37661220
84Legionellosis_Homo sapiens_hsa051340.37107346
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35638500
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.34504402
87Primary immunodeficiency_Homo sapiens_hsa053400.33222279
88Insulin signaling pathway_Homo sapiens_hsa049100.32294288
89Hippo signaling pathway_Homo sapiens_hsa043900.32143605
90Bladder cancer_Homo sapiens_hsa052190.31205347
91Metabolic pathways_Homo sapiens_hsa011000.30975049
92Galactose metabolism_Homo sapiens_hsa000520.29446717
93Colorectal cancer_Homo sapiens_hsa052100.29184684
94Hedgehog signaling pathway_Homo sapiens_hsa043400.28269648
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27850456
96Prostate cancer_Homo sapiens_hsa052150.26378842
97Fatty acid biosynthesis_Homo sapiens_hsa000610.25974004
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24937566
99Hepatitis C_Homo sapiens_hsa051600.24596762
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23764671
101Oxidative phosphorylation_Homo sapiens_hsa001900.23175101
102Arginine and proline metabolism_Homo sapiens_hsa003300.22772585
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22685793
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.22337376
105Non-small cell lung cancer_Homo sapiens_hsa052230.19681316
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.18989366
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18145114
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18026840
109Fatty acid degradation_Homo sapiens_hsa000710.17908117
110Protein export_Homo sapiens_hsa030600.16685552
111Apoptosis_Homo sapiens_hsa042100.16405916
112Chronic myeloid leukemia_Homo sapiens_hsa052200.14308909
113HIF-1 signaling pathway_Homo sapiens_hsa040660.13180161
114Small cell lung cancer_Homo sapiens_hsa052220.11416725
115Tryptophan metabolism_Homo sapiens_hsa003800.10728737
116Shigellosis_Homo sapiens_hsa051310.09482805
117Propanoate metabolism_Homo sapiens_hsa006400.09417643
118Measles_Homo sapiens_hsa051620.09399906
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.08726337
120Regulation of autophagy_Homo sapiens_hsa041400.07229865
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06056458
122Hepatitis B_Homo sapiens_hsa051610.05769444
123Pathways in cancer_Homo sapiens_hsa052000.04517452
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.03303943
125Phenylalanine metabolism_Homo sapiens_hsa003600.00863391

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