NELFE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein maturation by protein folding (GO:0022417)5.16128915
2ribosomal small subunit assembly (GO:0000028)4.94114188
3establishment of integrated proviral latency (GO:0075713)4.93824263
4establishment of viral latency (GO:0019043)4.91568503
5DNA strand elongation involved in DNA replication (GO:0006271)4.71011439
6regulation of mitochondrial translation (GO:0070129)4.60698550
7telomere maintenance via semi-conservative replication (GO:0032201)4.57915575
8DNA strand elongation (GO:0022616)4.46965639
9formation of translation preinitiation complex (GO:0001731)4.43024738
10maturation of SSU-rRNA (GO:0030490)4.29609042
11DNA replication initiation (GO:0006270)4.28661553
12DNA deamination (GO:0045006)4.24280157
13nucleobase biosynthetic process (GO:0046112)4.17833349
14viral transcription (GO:0019083)4.16632575
15DNA replication checkpoint (GO:0000076)4.13230244
16COPI coating of Golgi vesicle (GO:0048205)4.12140842
17Golgi transport vesicle coating (GO:0048200)4.12140842
18chaperone-mediated protein transport (GO:0072321)4.09228625
19translational termination (GO:0006415)4.08139196
20telomere maintenance via recombination (GO:0000722)4.06550948
21purine nucleobase biosynthetic process (GO:0009113)4.05733632
22ribosomal large subunit biogenesis (GO:0042273)4.00123270
23mitotic nuclear envelope reassembly (GO:0007084)3.95973799
24nuclear envelope reassembly (GO:0031468)3.95973799
25DNA unwinding involved in DNA replication (GO:0006268)3.89265106
26pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.86269720
27translational elongation (GO:0006414)3.82913283
28mitotic metaphase plate congression (GO:0007080)3.82652837
29mitotic recombination (GO:0006312)3.79124246
30ribosomal small subunit biogenesis (GO:0042274)3.76284265
31translational initiation (GO:0006413)3.73989938
32protein localization to kinetochore (GO:0034501)3.72942067
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65124840
34telomere maintenance via telomere lengthening (GO:0010833)3.62795040
35nucleotide-excision repair, DNA gap filling (GO:0006297)3.62686337
36regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.62306932
37pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.60691749
38ribonucleoprotein complex biogenesis (GO:0022613)3.59841997
392-deoxyribonucleotide biosynthetic process (GO:0009265)3.55838238
40deoxyribose phosphate biosynthetic process (GO:0046385)3.55838238
41folic acid-containing compound biosynthetic process (GO:0009396)3.55124348
42protein targeting to ER (GO:0045047)3.53030154
43cotranslational protein targeting to membrane (GO:0006613)3.52760606
44DNA replication-dependent nucleosome organization (GO:0034723)3.47399787
45DNA replication-dependent nucleosome assembly (GO:0006335)3.47399787
46ribosome biogenesis (GO:0042254)3.46473688
47GDP-mannose metabolic process (GO:0019673)3.42818773
48protein targeting to mitochondrion (GO:0006626)3.41433472
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40600024
50mitotic nuclear envelope disassembly (GO:0007077)3.40167561
51proteasome assembly (GO:0043248)3.38367163
52negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.36900021
53nucleobase-containing small molecule interconversion (GO:0015949)3.35427508
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.33278548
55protein localization to endoplasmic reticulum (GO:0070972)3.32165088
56establishment of protein localization to endoplasmic reticulum (GO:0072599)3.31733083
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29225562
58protein localization to chromosome, centromeric region (GO:0071459)3.29176959
59regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.28281149
60negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.26407168
61L-serine metabolic process (GO:0006563)3.25348490
62IMP biosynthetic process (GO:0006188)3.24660963
63chromatin remodeling at centromere (GO:0031055)3.24482248
64metaphase plate congression (GO:0051310)3.24037535
65viral life cycle (GO:0019058)3.21832783
66cellular protein complex disassembly (GO:0043624)3.21604340
67deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21325162
68ribosome assembly (GO:0042255)3.20723857
69spliceosomal snRNP assembly (GO:0000387)3.19656193
70proline biosynthetic process (GO:0006561)3.19170774
71CENP-A containing nucleosome assembly (GO:0034080)3.19142697
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.17834311
73positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.17373474
74peptidyl-arginine omega-N-methylation (GO:0035247)3.17240713
75establishment of protein localization to mitochondrion (GO:0072655)3.16417946
76rRNA processing (GO:0006364)3.16143006
77pyrimidine nucleotide catabolic process (GO:0006244)3.14965744
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.12918354
79guanosine-containing compound biosynthetic process (GO:1901070)3.10970829
80translation (GO:0006412)3.10960508
81pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.10599038
82negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08690284
83negative regulation of ligase activity (GO:0051352)3.08690284
84membrane disassembly (GO:0030397)3.08045951
85nuclear envelope disassembly (GO:0051081)3.08045951
86deoxyribonucleotide biosynthetic process (GO:0009263)3.07678449
87rRNA metabolic process (GO:0016072)3.07290621
88transcription-coupled nucleotide-excision repair (GO:0006283)3.06904675
89protein retention in ER lumen (GO:0006621)3.04606860
90folic acid metabolic process (GO:0046655)3.03913701
91ATP synthesis coupled proton transport (GO:0015986)3.03912282
92energy coupled proton transport, down electrochemical gradient (GO:0015985)3.03912282
93protein localization to mitochondrion (GO:0070585)3.03337847
94maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99212224
95iron-sulfur cluster assembly (GO:0016226)2.99105575
96metallo-sulfur cluster assembly (GO:0031163)2.99105575
97mitotic sister chromatid segregation (GO:0000070)2.98815707
98tRNA aminoacylation for protein translation (GO:0006418)2.97891290
99DNA replication-independent nucleosome assembly (GO:0006336)2.97589785
100DNA replication-independent nucleosome organization (GO:0034724)2.97589785
101regulation of translational fidelity (GO:0006450)2.96475898
102deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.95943901
103protein complex disassembly (GO:0043241)2.95315934
104de novo posttranslational protein folding (GO:0051084)2.92117522
105histone arginine methylation (GO:0034969)2.92035267
106regulation of double-strand break repair via homologous recombination (GO:0010569)2.91760480
107rRNA modification (GO:0000154)2.90682762
108nuclear pore organization (GO:0006999)2.90230673
109base-excision repair (GO:0006284)2.88700372
110de novo protein folding (GO:0006458)2.88480166
111establishment of chromosome localization (GO:0051303)2.88068896
112cell cycle G1/S phase transition (GO:0044843)2.87502806
113G1/S transition of mitotic cell cycle (GO:0000082)2.87502806
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87246819
115negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.86315599
116positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84542676
117kinetochore organization (GO:0051383)2.84228911
118tRNA aminoacylation (GO:0043039)2.83780988
119amino acid activation (GO:0043038)2.83780988
120intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82919708
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82919708
122virion assembly (GO:0019068)2.82439099
123signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81969499
124signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81969499
125signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81969499
126attachment of spindle microtubules to kinetochore (GO:0008608)2.81849309
127pentose-phosphate shunt (GO:0006098)2.81667610
128histone exchange (GO:0043486)2.80340325
129signal transduction involved in DNA damage checkpoint (GO:0072422)2.79954625
130signal transduction involved in DNA integrity checkpoint (GO:0072401)2.79954625
131macromolecular complex disassembly (GO:0032984)2.78990081
132regulation of spindle organization (GO:0090224)2.78973900
133somatic hypermutation of immunoglobulin genes (GO:0016446)2.76701765
134somatic diversification of immune receptors via somatic mutation (GO:0002566)2.76701765
135signal transduction involved in cell cycle checkpoint (GO:0072395)2.75765486
136mitotic chromosome condensation (GO:0007076)2.74750346
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.73813649
138telomere organization (GO:0032200)2.73414885
139pseudouridine synthesis (GO:0001522)2.72814143
140telomere maintenance (GO:0000723)2.72675648
141negative regulation of chromosome segregation (GO:0051985)2.71967516
142kinetochore assembly (GO:0051382)2.71522720
143regulation of cellular amino acid metabolic process (GO:0006521)2.71082546
144positive regulation of ligase activity (GO:0051351)2.70146482
145IMP metabolic process (GO:0046040)2.69158906
146cellular component biogenesis (GO:0044085)2.68462362
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67451955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.34109359
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.06878804
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78908008
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.38770598
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.97714456
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96012169
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90471810
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87647063
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85421004
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84705272
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.84678883
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.82194265
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.75342777
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71228154
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.68539425
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65831468
17XRN2_22483619_ChIP-Seq_HELA_Human2.33241793
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21043197
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16822402
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08796498
21VDR_23849224_ChIP-Seq_CD4+_Human2.07166512
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06969175
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04176091
24ZNF263_19887448_ChIP-Seq_K562_Human2.00020477
25E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99330144
26DCP1A_22483619_ChIP-Seq_HELA_Human1.94956429
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89968881
28AR_21909140_ChIP-Seq_LNCAP_Human1.87663441
29GABP_19822575_ChIP-Seq_HepG2_Human1.86919012
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84073751
31FOXP3_21729870_ChIP-Seq_TREG_Human1.82780625
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72313362
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72218401
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72203273
35TTF2_22483619_ChIP-Seq_HELA_Human1.70782041
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.70731159
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70428536
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65623747
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.64807066
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60963869
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60345856
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.58294232
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57828126
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.53682675
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51721184
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49264062
47MYC_22102868_ChIP-Seq_BL_Human1.46051299
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43804717
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43206300
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.42126696
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.41894486
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40505040
53KDM5A_27292631_Chip-Seq_BREAST_Human1.40128239
54CIITA_25753668_ChIP-Seq_RAJI_Human1.40071889
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39397895
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39258313
57TET1_21451524_ChIP-Seq_MESCs_Mouse1.38413896
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35271129
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31764338
60ELK1_19687146_ChIP-ChIP_HELA_Human1.30379458
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28514753
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27937775
63CTCF_18555785_ChIP-Seq_MESCs_Mouse1.25675652
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24689056
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23262499
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23018170
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21255504
68LXR_22292898_ChIP-Seq_THP-1_Human1.20496793
69ELK3_25401928_ChIP-Seq_HUVEC_Human1.20044494
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18782811
71PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18000270
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16907919
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16180467
74* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14318524
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12794856
76FOXP1_21924763_ChIP-Seq_HESCs_Human1.12062782
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11510861
78SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11484280
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10879670
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10602572
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09205089
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09103441
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09034014
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07651367
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.07347855
86RACK7_27058665_Chip-Seq_MCF-7_Human1.06954515
87VDR_21846776_ChIP-Seq_THP-1_Human1.06864513
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06458967
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05853502
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04371502
91KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04028246
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03862286
93TFEB_21752829_ChIP-Seq_HELA_Human1.03446421
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.00845892
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00564496
96P68_20966046_ChIP-Seq_HELA_Human1.00074836
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98989477
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98626375
99CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97335202
100SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95981345
101ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.94439977
102CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93911099
103YY1_22570637_ChIP-Seq_MALME-3M_Human0.92843196
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92514752
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.92234561
106PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91920885
107SPI1_23547873_ChIP-Seq_NB4_Human0.91679606
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91427900
109TP63_19390658_ChIP-ChIP_HaCaT_Human0.89068923
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87242517
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86501289
112ELK1_22589737_ChIP-Seq_MCF10A_Human0.86400607
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86162971
114CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85225146
115MYC_18940864_ChIP-ChIP_HL60_Human0.84360161
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82910046
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79397997
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78520966
119CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78243725
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75158382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38995391
2MP0004957_abnormal_blastocyst_morpholog4.03240585
3MP0010094_abnormal_chromosome_stability4.00733620
4MP0003111_abnormal_nucleus_morphology3.94693455
5MP0003077_abnormal_cell_cycle3.52409191
6MP0008058_abnormal_DNA_repair2.98339643
7MP0008057_abnormal_DNA_replication2.92697614
8MP0008007_abnormal_cellular_replicative2.68371640
9MP0008260_abnormal_autophagy2.59626233
10MP0005058_abnormal_lysosome_morphology2.51649437
11MP0008932_abnormal_embryonic_tissue2.26472857
12MP0003123_paternal_imprinting2.24470791
13MP0001730_embryonic_growth_arrest2.13097337
14MP0005083_abnormal_biliary_tract2.00661752
15MP0003806_abnormal_nucleotide_metabolis1.95651169
16MP0000350_abnormal_cell_proliferation1.93450446
17MP0002396_abnormal_hematopoietic_system1.92908017
18MP0004233_abnormal_muscle_weight1.90238962
19MP0010352_gastrointestinal_tract_polyps1.81436548
20MP0003786_premature_aging1.81307881
21MP0005501_abnormal_skin_physiology1.76443535
22MP0003191_abnormal_cellular_cholesterol1.76130053
23MP0005257_abnormal_intraocular_pressure1.72787833
24MP0000490_abnormal_crypts_of1.65062838
25MP0006035_abnormal_mitochondrial_morpho1.64838890
26MP0003718_maternal_effect1.63410067
27MP0001346_abnormal_lacrimal_gland1.61582194
28MP0008877_abnormal_DNA_methylation1.59341241
29MP0009333_abnormal_splenocyte_physiolog1.51834542
30MP0010307_abnormal_tumor_latency1.51669947
31MP0009697_abnormal_copulation1.50310138
32MP0003186_abnormal_redox_activity1.49352441
33MP0001672_abnormal_embryogenesis/_devel1.48158649
34MP0005380_embryogenesis_phenotype1.48158649
35MP0001697_abnormal_embryo_size1.45538295
36MP0002653_abnormal_ependyma_morphology1.45433566
37MP0006292_abnormal_olfactory_placode1.44154198
38MP0000313_abnormal_cell_death1.43012640
39MP0002080_prenatal_lethality1.42193493
40MP0008789_abnormal_olfactory_epithelium1.40979747
41MP0002019_abnormal_tumor_incidence1.39597535
42MP0000750_abnormal_muscle_regeneration1.38743677
43MP0000678_abnormal_parathyroid_gland1.37217179
44MP0001545_abnormal_hematopoietic_system1.34928633
45MP0005397_hematopoietic_system_phenotyp1.34928633
46MP0002210_abnormal_sex_determination1.34656056
47MP0004808_abnormal_hematopoietic_stem1.33810794
48MP0002877_abnormal_melanocyte_morpholog1.32725950
49MP0004858_abnormal_nervous_system1.31974119
50MP0003984_embryonic_growth_retardation1.30973027
51MP0002088_abnormal_embryonic_growth/wei1.28195385
52MP0001929_abnormal_gametogenesis1.24993210
53MP0002085_abnormal_embryonic_tissue1.21285055
54MP0001727_abnormal_embryo_implantation1.19777493
55MP0001145_abnormal_male_reproductive1.18121756
56MP0010030_abnormal_orbit_morphology1.17169079
57MP0009840_abnormal_foam_cell1.15197233
58MP0003315_abnormal_perineum_morphology1.13792304
59MP0009379_abnormal_foot_pigmentation1.08759756
60MP0003567_abnormal_fetal_cardiomyocyte1.08000836
61MP0004197_abnormal_fetal_growth/weight/1.07563068
62MP0002086_abnormal_extraembryonic_tissu1.07302761
63MP0000358_abnormal_cell_content/1.06797978
64MP0002084_abnormal_developmental_patter1.05066794
65MP0005410_abnormal_fertilization1.04744900
66MP0002160_abnormal_reproductive_system1.04133621
67MP0005499_abnormal_olfactory_system1.02381372
68MP0005394_taste/olfaction_phenotype1.02381372
69MP0005165_increased_susceptibility_to1.02350070
70MP0003763_abnormal_thymus_physiology1.01339840
71MP0003121_genomic_imprinting1.00150248
72MP0002722_abnormal_immune_system0.99432481
73MP0000689_abnormal_spleen_morphology0.98899591
74MP0001853_heart_inflammation0.98401600
75MP0009053_abnormal_anal_canal0.97882029
76MP0000653_abnormal_sex_gland0.96734943
77MP0000858_altered_metastatic_potential0.96679894
78MP0002398_abnormal_bone_marrow0.96281682
79MP0000703_abnormal_thymus_morphology0.94892903
80MP0005076_abnormal_cell_differentiation0.93379871
81MP0003705_abnormal_hypodermis_morpholog0.93285005
82MP0005330_cardiomyopathy0.93097484
83MP0005389_reproductive_system_phenotype0.90036266
84MP0000685_abnormal_immune_system0.89927943
85MP0002132_abnormal_respiratory_system0.89640408
86MP0000343_altered_response_to0.89448722
87MP0003075_altered_response_to0.88920620
88MP0003119_abnormal_digestive_system0.88415493
89MP0001835_abnormal_antigen_presentation0.86814823
90MP0002429_abnormal_blood_cell0.86655557
91MP0009278_abnormal_bone_marrow0.85964188
92MP0001881_abnormal_mammary_gland0.85607863
93MP0001293_anophthalmia0.85341425
94MP0003942_abnormal_urinary_system0.84879084
95MP0005023_abnormal_wound_healing0.81365515
96MP0001119_abnormal_female_reproductive0.81025098
97MP0003656_abnormal_erythrocyte_physiolo0.78616192
98MP0000049_abnormal_middle_ear0.78515422
99MP0006036_abnormal_mitochondrial_physio0.77177237
100MP0002796_impaired_skin_barrier0.77079286
101MP0001764_abnormal_homeostasis0.76668536
102MP0004133_heterotaxia0.75355674
103MP0005670_abnormal_white_adipose0.74704173
104MP0000598_abnormal_liver_morphology0.74662947
105MP0001529_abnormal_vocalization0.74633563
106MP0003698_abnormal_male_reproductive0.73113525
107MP0003436_decreased_susceptibility_to0.72037529
108MP0005584_abnormal_enzyme/coenzyme_acti0.71544850
109MP0003890_abnormal_embryonic-extraembry0.71072552
110MP0009672_abnormal_birth_weight0.70910054
111MP0002405_respiratory_system_inflammati0.70798186
112MP0003221_abnormal_cardiomyocyte_apopto0.70668059
113MP0000716_abnormal_immune_system0.70557376
114MP0002111_abnormal_tail_morphology0.69876612
115MP0000477_abnormal_intestine_morphology0.68250213
116MP0005623_abnormal_meninges_morphology0.66729280
117MP0001919_abnormal_reproductive_system0.65411491
118MP0005384_cellular_phenotype0.65379007
119MP0005220_abnormal_exocrine_pancreas0.65309171
120MP0003566_abnormal_cell_adhesion0.64901333
121MP0002139_abnormal_hepatobiliary_system0.64753822
122MP0006054_spinal_hemorrhage0.62854605
123MP0001800_abnormal_humoral_immune0.62427904
124MP0003941_abnormal_skin_development0.62387417
125MP0000537_abnormal_urethra_morphology0.61561908
126MP0005621_abnormal_cell_physiology0.60751837
127MP0003453_abnormal_keratinocyte_physiol0.60387082
128MP0001849_ear_inflammation0.60030136
129MP0000751_myopathy0.58619354
130MP0002161_abnormal_fertility/fecundity0.58507556
131MP0004185_abnormal_adipocyte_glucose0.58376551
132MP0004264_abnormal_extraembryonic_tissu0.58239126
133MP0003122_maternal_imprinting0.58119507
134MP0002452_abnormal_antigen_presenting0.57546682
135MP0009785_altered_susceptibility_to0.57191667
136MP0000681_abnormal_thyroid_gland0.57171447
137MP0001542_abnormal_bone_strength0.56701250
138MP0005451_abnormal_body_composition0.56615996
139MP0001216_abnormal_epidermal_layer0.56115716
140MP0000749_muscle_degeneration0.56026137
141MP0005319_abnormal_enzyme/_coenzyme0.56009873

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.75742258
2Birth length less than 3rd percentile (HP:0003561)4.54107007
3Abnormal number of erythroid precursors (HP:0012131)4.47397422
4Reticulocytopenia (HP:0001896)4.30021026
5Abnormal mitochondria in muscle tissue (HP:0008316)4.16266696
6Acute necrotizing encephalopathy (HP:0006965)3.86177714
7Hepatocellular necrosis (HP:0001404)3.78983985
8Breast hypoplasia (HP:0003187)3.70791861
9Carpal bone hypoplasia (HP:0001498)3.63818098
10Mitochondrial inheritance (HP:0001427)3.59259577
11Ragged-red muscle fibers (HP:0003200)3.51164103
12Oral leukoplakia (HP:0002745)3.46506804
13Selective tooth agenesis (HP:0001592)3.40584542
14Acute encephalopathy (HP:0006846)3.40534771
15Degeneration of anterior horn cells (HP:0002398)3.31770499
16Abnormality of the anterior horn cell (HP:0006802)3.31770499
17Macrocytic anemia (HP:0001972)3.28038408
18Increased CSF lactate (HP:0002490)3.24731673
19Hepatic necrosis (HP:0002605)3.23144293
20Microretrognathia (HP:0000308)3.21865703
21Increased serum pyruvate (HP:0003542)3.21132966
22Abnormality of glycolysis (HP:0004366)3.19460594
23Colon cancer (HP:0003003)3.15308743
24Abnormal gallbladder physiology (HP:0012438)3.10165913
25Cholecystitis (HP:0001082)3.10165913
26Increased intramyocellular lipid droplets (HP:0012240)3.10073722
27Multiple enchondromatosis (HP:0005701)3.09146190
28Rough bone trabeculation (HP:0100670)3.08371094
29Cortical dysplasia (HP:0002539)3.01270908
30Upper limb muscle weakness (HP:0003484)2.99088586
31Patellar aplasia (HP:0006443)2.97203884
32Vertebral compression fractures (HP:0002953)2.95213994
33Aplasia/Hypoplasia of the patella (HP:0006498)2.86291820
34Increased muscle lipid content (HP:0009058)2.83345096
35Exercise intolerance (HP:0003546)2.80705317
36Pallor (HP:0000980)2.79485798
37Lactic acidosis (HP:0003128)2.77898610
38Trismus (HP:0000211)2.73862915
39Cerebral edema (HP:0002181)2.73516490
40Thrombocytosis (HP:0001894)2.72629625
41Abnormal protein glycosylation (HP:0012346)2.71581447
42Abnormal glycosylation (HP:0012345)2.71581447
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71581447
44Abnormal protein N-linked glycosylation (HP:0012347)2.71581447
4511 pairs of ribs (HP:0000878)2.71137743
46Absent thumb (HP:0009777)2.71037833
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.68719522
48Progressive macrocephaly (HP:0004481)2.66636289
49Impulsivity (HP:0100710)2.64158710
50Aplastic anemia (HP:0001915)2.50591540
51Secondary amenorrhea (HP:0000869)2.49997961
52Cerebral hypomyelination (HP:0006808)2.45318637
53Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.40969334
54Increased hepatocellular lipid droplets (HP:0006565)2.37758990
55Poor head control (HP:0002421)2.36916862
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.34943927
57Emotional lability (HP:0000712)2.34214723
58Neoplasm of the pancreas (HP:0002894)2.32496966
59Abnormality of pyrimidine metabolism (HP:0004353)2.32133044
60Hand muscle atrophy (HP:0009130)2.28057158
61Respiratory failure (HP:0002878)2.27527332
62Renal Fanconi syndrome (HP:0001994)2.26756700
63Entropion (HP:0000621)2.26116236
64Abnormality of the preputium (HP:0100587)2.25037975
65Short nail (HP:0001799)2.24868485
66Type I transferrin isoform profile (HP:0003642)2.23326496
67Chromsome breakage (HP:0040012)2.22938600
68Premature ovarian failure (HP:0008209)2.22239405
69Abnormal spermatogenesis (HP:0008669)2.22229014
70Abnormal trabecular bone morphology (HP:0100671)2.22188238
71Meckel diverticulum (HP:0002245)2.21624016
72Lipid accumulation in hepatocytes (HP:0006561)2.21152048
73Premature graying of hair (HP:0002216)2.20893403
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.20634824
75Decreased activity of mitochondrial respiratory chain (HP:0008972)2.20634824
76Cleft eyelid (HP:0000625)2.19108071
77Abnormality of chromosome stability (HP:0003220)2.19005319
78Hypokinesia (HP:0002375)2.18440521
79Myelodysplasia (HP:0002863)2.13402627
80Hypertensive crisis (HP:0100735)2.10906021
81Horseshoe kidney (HP:0000085)2.10220373
82Abnormality of the ileum (HP:0001549)2.09737944
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08872549
84Broad distal phalanx of finger (HP:0009836)2.08813052
85Death in infancy (HP:0001522)2.06661969
86Abnormality of the distal phalanges of the toes (HP:0010182)2.05858657
87Respiratory difficulties (HP:0002880)2.04196537
88Distal upper limb amyotrophy (HP:0007149)2.04009788
89Upper limb amyotrophy (HP:0009129)2.04009788
90Cellular immunodeficiency (HP:0005374)2.01401397
91Glossoptosis (HP:0000162)2.00841238
92Bone marrow hypocellularity (HP:0005528)2.00031479
93Irregular epiphyses (HP:0010582)1.99595823
94Distal lower limb muscle weakness (HP:0009053)1.98701514
95Premature rupture of membranes (HP:0001788)1.98667206
96Opisthotonus (HP:0002179)1.98428224
97Absent radius (HP:0003974)1.96165321
98Agnosia (HP:0010524)1.95648758
99Progressive microcephaly (HP:0000253)1.95570957
100Achilles tendon contracture (HP:0001771)1.94454287
101Personality changes (HP:0000751)1.93605595
102Atresia of the external auditory canal (HP:0000413)1.93561544
103Facial cleft (HP:0002006)1.93114363
104Megaloblastic anemia (HP:0001889)1.90973147
105Duodenal stenosis (HP:0100867)1.90036245
106Small intestinal stenosis (HP:0012848)1.90036245
107Abnormal lung lobation (HP:0002101)1.89847575
108Pancytopenia (HP:0001876)1.89209343
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89132243
110Absent epiphyses (HP:0010577)1.89132243
111Abnormality of reticulocytes (HP:0004312)1.88701333
112Ependymoma (HP:0002888)1.88108242
113Testicular atrophy (HP:0000029)1.87688237
114Medulloblastoma (HP:0002885)1.86825483
115Sparse eyelashes (HP:0000653)1.86822306
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.86694919
117Insomnia (HP:0100785)1.86237127
118Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85634652
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85146516
120CNS demyelination (HP:0007305)1.84492359
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.84346298
122Supernumerary spleens (HP:0009799)1.83014982
123Triphalangeal thumb (HP:0001199)1.82702166
124Down-sloping shoulders (HP:0200021)1.81214012
125Fasciculations (HP:0002380)1.80719334
126Tracheoesophageal fistula (HP:0002575)1.79766406
127Slender long bone (HP:0003100)1.79462665
128Rhabdomyosarcoma (HP:0002859)1.78810584
129Progressive muscle weakness (HP:0003323)1.78374636
130Hypoplasia of the radius (HP:0002984)1.77902688
131Cerebellar hypoplasia (HP:0001321)1.77855169
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.77616593
133Optic nerve coloboma (HP:0000588)1.77423013
134Stenosis of the external auditory canal (HP:0000402)1.76856214
135Reticulocytosis (HP:0001923)1.75337728
136Squamous cell carcinoma (HP:0002860)1.74779136
137Aplasia involving forearm bones (HP:0009822)1.74355995
138Absent forearm bone (HP:0003953)1.74355995
139Nasal polyposis (HP:0100582)1.74012982
140Nausea (HP:0002018)1.73778600
141Sloping forehead (HP:0000340)1.73147840
142Truncus arteriosus (HP:0001660)1.72730817
143J-shaped sella turcica (HP:0002680)1.71379263
144Abnormality of glycolipid metabolism (HP:0010969)1.71195271
145Abnormality of liposaccharide metabolism (HP:0010968)1.71195271
146Abnormality of glycosphingolipid metabolism (HP:0004343)1.71195271
147Diaphragmatic weakness (HP:0009113)1.70896746
148Prolonged neonatal jaundice (HP:0006579)1.70794025
149Generalized amyotrophy (HP:0003700)1.69282731
150Axonal loss (HP:0003447)1.68686683
151Petechiae (HP:0000967)1.68651589
152Abnormal umbilical cord blood vessels (HP:0011403)1.68534881
153Single umbilical artery (HP:0001195)1.68534881
154Abnormality of the fetal cardiovascular system (HP:0010948)1.68534881
155Microvesicular hepatic steatosis (HP:0001414)1.68129147
156Abnormal number of incisors (HP:0011064)1.67807879
157Exertional dyspnea (HP:0002875)1.67661768
158Increased serum lactate (HP:0002151)1.66412092
159Abnormality of the nasal mucosa (HP:0000433)1.65784016
160Abnormality of the umbilical cord (HP:0010881)1.65159670
161Abnormality of T cell physiology (HP:0011840)1.63975553
162Reduced antithrombin III activity (HP:0001976)1.63888584
163Missing ribs (HP:0000921)1.63551148
164Abnormality of the duodenum (HP:0002246)1.62732520
165Lymphoma (HP:0002665)1.61741100
166Basal cell carcinoma (HP:0002671)1.60882627
167Abnormality of the heme biosynthetic pathway (HP:0010472)1.59234071
168High pitched voice (HP:0001620)1.58573394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.10516222
2BUB14.98656245
3WEE13.87781479
4EIF2AK13.56731341
5CDC73.29579800
6NME23.12850448
7NEK22.73830200
8ARAF2.65017735
9EIF2AK32.38118183
10RPS6KA42.24580214
11STK162.10890362
12TESK22.08476819
13LIMK12.02617910
14BRSK21.98454063
15TTK1.96684932
16SRPK11.96277038
17PASK1.95221156
18PLK41.85033593
19PLK11.76257353
20ACVR1B1.75353831
21TLK11.71996183
22EEF2K1.68793561
23BCKDK1.61523988
24RPS6KB21.56121033
25TGFBR11.54226765
26DYRK31.53662727
27CDK191.53544796
28SMG11.51325294
29CDK71.49749855
30NEK11.47259391
31TSSK61.40931243
32BRSK11.40688904
33TESK11.40467669
34* AURKB1.40011964
35VRK11.37076268
36TAOK21.36561002
37PIM21.33251116
38ATR1.31821262
39AURKA1.27887766
40MAP2K31.26836829
41EPHA21.23838888
42PAK41.18405888
43MAP3K101.14642220
44MAP3K81.12599656
45CDK41.12048574
46KDR1.11828930
47MAP4K11.10964587
48CHEK21.08127523
49MKNK11.06672023
50MAPKAPK31.06025361
51BRAF0.99269907
52PDK30.97412645
53PDK40.97412645
54PLK30.97304015
55MAP3K110.95007885
56DAPK10.94944779
57PIM10.94457479
58STK100.92011917
59CHEK10.91243253
60SCYL20.90280072
61ZAP700.88639719
62FLT30.87207719
63IRAK30.87109875
64MAP4K20.86749115
65ERN10.86358636
66MST1R0.84644360
67LMTK20.84603787
68CCNB10.84116703
69LRRK20.82476750
70ICK0.80520253
71DYRK20.78803018
72EIF2AK20.78368530
73STK40.77074742
74PAK10.75081134
75MAP3K120.74666951
76TRIB30.72995179
77DAPK30.71597922
78CSNK1G30.70468064
79MAP2K70.68969429
80CSNK2A10.66760038
81ZAK0.66693590
82PKN20.66408273
83CDK140.64676659
84MAP2K20.64409155
85BMX0.63493219
86CSNK2A20.63463365
87PRKCI0.62344642
88CDK20.62266289
89MAP3K30.61634291
90MAPKAPK50.60931824
91CDK11A0.60766896
92PBK0.60588013
93CDK120.59319492
94PDK20.58696755
95NEK90.58452388
96MOS0.58092314
97ATM0.57799961
98IKBKB0.52923300
99RAF10.52793592
100RPS6KA50.52390894
101CDK150.51010916
102MKNK20.50838132
103EPHB20.50176866
104AKT20.49180812
105CDK180.48100249
106PTK20.47499584
107BLK0.45899627
108ERBB40.45877029
109ILK0.44284200
110CSNK1G10.43505848
111CSNK1A1L0.42726099
112TBK10.42601651
113NLK0.41601688
114STK30.41440995
115CDK80.41068903
116CHUK0.40208202
117CDK10.40105080
118BTK0.40068760
119PRPF4B0.40066285
120JAK30.39693021
121MAP3K10.38736643
122CAMK2G0.38515689
123MAPK110.37211642
124MELK0.37085242
125EPHB10.36308649
126ABL20.36262264
127ALK0.36231799
128NTRK10.36138825
129MAP3K50.34787403
130TYK20.34432079
131CDK60.33459219
132MTOR0.33406597
133IRAK40.32545849
134DYRK1B0.29353697
135NME10.29341112
136MAP2K60.28785438
137CDK90.28177609
138CSNK1G20.28100642
139CLK10.25173401

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79366230
2Mismatch repair_Homo sapiens_hsa034303.95643087
3Ribosome_Homo sapiens_hsa030103.78159998
4Proteasome_Homo sapiens_hsa030503.57370110
5Base excision repair_Homo sapiens_hsa034103.14742842
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.11636076
7Homologous recombination_Homo sapiens_hsa034402.90122807
8RNA polymerase_Homo sapiens_hsa030202.90068552
9Spliceosome_Homo sapiens_hsa030402.82321550
10RNA transport_Homo sapiens_hsa030132.69669790
11Nucleotide excision repair_Homo sapiens_hsa034202.61887655
12Pyrimidine metabolism_Homo sapiens_hsa002402.58630063
13One carbon pool by folate_Homo sapiens_hsa006702.44365625
14Cell cycle_Homo sapiens_hsa041102.25671310
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04762951
16Fatty acid elongation_Homo sapiens_hsa000621.88011339
17Fanconi anemia pathway_Homo sapiens_hsa034601.70369988
18Folate biosynthesis_Homo sapiens_hsa007901.56793681
19Basal transcription factors_Homo sapiens_hsa030221.56076703
20Alzheimers disease_Homo sapiens_hsa050101.48856171
21Non-homologous end-joining_Homo sapiens_hsa034501.47998133
22RNA degradation_Homo sapiens_hsa030181.43237184
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41431035
24Vitamin B6 metabolism_Homo sapiens_hsa007501.36917188
25p53 signaling pathway_Homo sapiens_hsa041151.35556948
26Selenocompound metabolism_Homo sapiens_hsa004501.31706307
27Purine metabolism_Homo sapiens_hsa002301.31396045
28Sulfur relay system_Homo sapiens_hsa041221.30616655
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.26741290
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25601366
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24090546
32Pentose phosphate pathway_Homo sapiens_hsa000301.23341836
33mRNA surveillance pathway_Homo sapiens_hsa030151.20368367
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19063279
35Protein export_Homo sapiens_hsa030601.11401748
36Biosynthesis of amino acids_Homo sapiens_hsa012301.11300978
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.09843989
38Epstein-Barr virus infection_Homo sapiens_hsa051691.04129517
39Vibrio cholerae infection_Homo sapiens_hsa051101.01406357
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98716618
41Glutathione metabolism_Homo sapiens_hsa004800.98654102
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92376819
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.91036026
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89965108
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.88960136
46Phenylalanine metabolism_Homo sapiens_hsa003600.88512220
47Herpes simplex infection_Homo sapiens_hsa051680.88289648
48Antigen processing and presentation_Homo sapiens_hsa046120.87195481
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84146999
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82183236
51Steroid biosynthesis_Homo sapiens_hsa001000.80198754
52Legionellosis_Homo sapiens_hsa051340.79742616
53Systemic lupus erythematosus_Homo sapiens_hsa053220.78925569
54Carbon metabolism_Homo sapiens_hsa012000.76430043
55Cardiac muscle contraction_Homo sapiens_hsa042600.73688360
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73397530
57Fructose and mannose metabolism_Homo sapiens_hsa000510.69473288
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69284485
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68454308
60Viral carcinogenesis_Homo sapiens_hsa052030.63958932
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63590864
62Tyrosine metabolism_Homo sapiens_hsa003500.60798478
63Huntingtons disease_Homo sapiens_hsa050160.58605892
64HTLV-I infection_Homo sapiens_hsa051660.57220096
65Oocyte meiosis_Homo sapiens_hsa041140.52667750
66Thyroid cancer_Homo sapiens_hsa052160.52164031
67Galactose metabolism_Homo sapiens_hsa000520.51340864
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.51214947
69N-Glycan biosynthesis_Homo sapiens_hsa005100.50751438
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49579018
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.48425101
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48140169
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.46996632
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46086577
75Fatty acid metabolism_Homo sapiens_hsa012120.45403807
76Apoptosis_Homo sapiens_hsa042100.44998120
77Lysosome_Homo sapiens_hsa041420.42666101
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42640308
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42412914
80Metabolic pathways_Homo sapiens_hsa011000.40526340
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39951127
82Sulfur metabolism_Homo sapiens_hsa009200.39758909
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39385113
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38570498
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.38322555
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38072842
87Primary immunodeficiency_Homo sapiens_hsa053400.37981132
88Parkinsons disease_Homo sapiens_hsa050120.36633337
89Measles_Homo sapiens_hsa051620.35883183
90Arginine and proline metabolism_Homo sapiens_hsa003300.33840475
91Small cell lung cancer_Homo sapiens_hsa052220.33029397
92Shigellosis_Homo sapiens_hsa051310.32502209
93Salmonella infection_Homo sapiens_hsa051320.32096598
94NF-kappa B signaling pathway_Homo sapiens_hsa040640.32067593
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31995276
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31387907
97Influenza A_Homo sapiens_hsa051640.30998269
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30984956
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29515579
100Pyruvate metabolism_Homo sapiens_hsa006200.27519404
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27449797
102Arachidonic acid metabolism_Homo sapiens_hsa005900.27027772
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.26646677
104Collecting duct acid secretion_Homo sapiens_hsa049660.25563355
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25065345
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25049853
107Regulation of autophagy_Homo sapiens_hsa041400.24969417
108Fat digestion and absorption_Homo sapiens_hsa049750.24266705
109Bladder cancer_Homo sapiens_hsa052190.23237583
110Chemical carcinogenesis_Homo sapiens_hsa052040.22938790
111Other glycan degradation_Homo sapiens_hsa005110.19985050
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19702855
113Alcoholism_Homo sapiens_hsa050340.19634012
114Asthma_Homo sapiens_hsa053100.19357640
115Endocytosis_Homo sapiens_hsa041440.19079988
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.19079208
117Oxidative phosphorylation_Homo sapiens_hsa001900.18888331
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.18549080
119Leishmaniasis_Homo sapiens_hsa051400.17995674
120Prion diseases_Homo sapiens_hsa050200.17955422
121Propanoate metabolism_Homo sapiens_hsa006400.16404379
122Synaptic vesicle cycle_Homo sapiens_hsa047210.14799416
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14675848
124Acute myeloid leukemia_Homo sapiens_hsa052210.14184075
125Hepatitis B_Homo sapiens_hsa051610.13519877
126MicroRNAs in cancer_Homo sapiens_hsa052060.13448706
127Vitamin digestion and absorption_Homo sapiens_hsa049770.12741403
128Peroxisome_Homo sapiens_hsa041460.12283780
129Basal cell carcinoma_Homo sapiens_hsa052170.11654038
130Notch signaling pathway_Homo sapiens_hsa043300.11100809
131Linoleic acid metabolism_Homo sapiens_hsa005910.10743638

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