NEMF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the ribosome quality control complex. The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebral cortex radially oriented cell migration (GO:0021799)4.86780388
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85711889
3DNA ligation (GO:0006266)3.80044741
4RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.61260784
5substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.61065354
6substrate-independent telencephalic tangential migration (GO:0021826)3.61065354
7regulation of heat generation (GO:0031650)3.55806433
8neural tube formation (GO:0001841)3.48766923
9behavioral response to nicotine (GO:0035095)3.48144730
10nucleoside diphosphate catabolic process (GO:0009134)3.45745320
11head development (GO:0060322)3.42324281
12oxidative phosphorylation (GO:0006119)3.41497596
13regulation of cilium movement (GO:0003352)3.37753894
14establishment of integrated proviral latency (GO:0075713)3.35686422
15limb bud formation (GO:0060174)3.32871310
16positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27936993
17establishment of protein localization to Golgi (GO:0072600)3.26900332
18kinetochore organization (GO:0051383)3.25754788
197-methylguanosine RNA capping (GO:0009452)3.25343095
20RNA capping (GO:0036260)3.25343095
21establishment of nucleus localization (GO:0040023)3.21017487
22signal peptide processing (GO:0006465)3.18024178
23DNA damage response, detection of DNA damage (GO:0042769)3.17740184
24histone H2B ubiquitination (GO:0033523)3.16485167
257-methylguanosine mRNA capping (GO:0006370)3.15961179
26establishment of viral latency (GO:0019043)3.13878446
27transcription elongation from RNA polymerase I promoter (GO:0006362)3.12820330
28response to nerve growth factor (GO:1990089)3.11563690
29cellular response to nerve growth factor stimulus (GO:1990090)3.11563690
30cerebral cortex cell migration (GO:0021795)3.07872151
31epithelial cilium movement (GO:0003351)3.07042183
32prenylation (GO:0097354)3.06448238
33protein prenylation (GO:0018342)3.06448238
34DNA-dependent DNA replication (GO:0006261)3.04319231
35meiotic chromosome segregation (GO:0045132)3.03382947
36presynaptic membrane assembly (GO:0097105)3.03376915
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.01317141
38cilium morphogenesis (GO:0060271)3.00371128
39intracellular lipid transport (GO:0032365)2.99530618
40positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.98931967
41protein targeting to Golgi (GO:0000042)2.98898237
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98847468
43mitochondrial respiratory chain complex I assembly (GO:0032981)2.98847468
44NADH dehydrogenase complex assembly (GO:0010257)2.98847468
45intraciliary transport (GO:0042073)2.98663799
46water-soluble vitamin biosynthetic process (GO:0042364)2.97642611
47axoneme assembly (GO:0035082)2.91355940
48sister chromatid cohesion (GO:0007062)2.91027373
49negative regulation of DNA-dependent DNA replication (GO:2000104)2.90395930
50protein localization to endosome (GO:0036010)2.90156313
51regulation of DNA endoreduplication (GO:0032875)2.90153527
52CENP-A containing nucleosome assembly (GO:0034080)2.87199332
53microtubule anchoring (GO:0034453)2.87193355
54response to pheromone (GO:0019236)2.85962168
55proteasome assembly (GO:0043248)2.85120116
56sympathetic nervous system development (GO:0048485)2.82721239
57protein neddylation (GO:0045116)2.81262782
58termination of RNA polymerase I transcription (GO:0006363)2.80851203
59C4-dicarboxylate transport (GO:0015740)2.80113810
60behavioral response to ethanol (GO:0048149)2.79910396
61pyrimidine nucleobase catabolic process (GO:0006208)2.79866688
62L-fucose catabolic process (GO:0042355)2.79547651
63fucose catabolic process (GO:0019317)2.79547651
64L-fucose metabolic process (GO:0042354)2.79547651
65positive regulation of cardiac muscle cell differentiation (GO:2000727)2.78901427
66nonmotile primary cilium assembly (GO:0035058)2.77636123
67protein complex biogenesis (GO:0070271)2.77193189
68centriole replication (GO:0007099)2.75783411
69transcription elongation from RNA polymerase III promoter (GO:0006385)2.74276445
70termination of RNA polymerase III transcription (GO:0006386)2.74276445
71atrial cardiac muscle cell action potential (GO:0086014)2.73956881
72chromatin remodeling at centromere (GO:0031055)2.73433071
73recombinational repair (GO:0000725)2.72963870
74resolution of meiotic recombination intermediates (GO:0000712)2.72461087
75double-strand break repair via homologous recombination (GO:0000724)2.72272746
76kinetochore assembly (GO:0051382)2.70938593
77hindbrain development (GO:0030902)2.69137278
78transcription from RNA polymerase III promoter (GO:0006383)2.68382942
79presynaptic membrane organization (GO:0097090)2.67679026
80developmental pigmentation (GO:0048066)2.66783889
81protein polyglutamylation (GO:0018095)2.65463460
82positive regulation of protein homodimerization activity (GO:0090073)2.64252862
83axon ensheathment in central nervous system (GO:0032291)2.64145800
84central nervous system myelination (GO:0022010)2.64145800
85GTP biosynthetic process (GO:0006183)2.63708464
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63473708
87GPI anchor metabolic process (GO:0006505)2.62800305
88mannosylation (GO:0097502)2.62221918
89retrograde transport, vesicle recycling within Golgi (GO:0000301)2.61524020
90histone H3-K4 trimethylation (GO:0080182)2.61504496
91adaptation of signaling pathway (GO:0023058)2.61151049
92olfactory bulb development (GO:0021772)2.60869015
93transcription-coupled nucleotide-excision repair (GO:0006283)2.58418698
94protein localization to cilium (GO:0061512)2.57980397
95long-chain fatty acid biosynthetic process (GO:0042759)2.57561468
96positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.56369735
97DNA strand renaturation (GO:0000733)2.56313302
98cilium organization (GO:0044782)2.56094981
99positive regulation of potassium ion transmembrane transport (GO:1901381)2.55857685
100positive regulation of histone H3-K4 methylation (GO:0051571)2.54715975
101left/right axis specification (GO:0070986)2.54194163
102ether lipid metabolic process (GO:0046485)2.53755824
103negative regulation of multicellular organism growth (GO:0040015)2.52926894
104regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.52577792
105cilium assembly (GO:0042384)2.51583907
106poly(A)+ mRNA export from nucleus (GO:0016973)2.51267611
107mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50584725
108microtubule depolymerization (GO:0007019)2.50085793
109peptidyl-histidine modification (GO:0018202)2.48050012
110nucleus localization (GO:0051647)2.47947245
111C-terminal protein lipidation (GO:0006501)2.47884500
112C-terminal protein amino acid modification (GO:0018410)2.47294373
113L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.46894466
114transcription initiation from RNA polymerase I promoter (GO:0006361)2.45854330
115RNA-dependent DNA replication (GO:0006278)2.45380533
116transcription from RNA polymerase I promoter (GO:0006360)2.45129196
117protein localization to Golgi apparatus (GO:0034067)2.45019221
118organelle disassembly (GO:1903008)2.44639633
119mechanosensory behavior (GO:0007638)2.44531274
120negative regulation of oligodendrocyte differentiation (GO:0048715)2.44417063
121regulation of sarcomere organization (GO:0060297)2.44283784
122mitochondrial respiratory chain complex assembly (GO:0033108)2.42571489
123respiratory chain complex IV assembly (GO:0008535)2.41943273
124cornea development in camera-type eye (GO:0061303)2.41669293
125negative regulation of mast cell activation (GO:0033004)2.41183672
126preassembly of GPI anchor in ER membrane (GO:0016254)2.40942814
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40677084
128regulation of protein kinase A signaling (GO:0010738)2.40561917
129response to X-ray (GO:0010165)2.40119280
130startle response (GO:0001964)2.39436685
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38056014
132nucleobase catabolic process (GO:0046113)2.37867925
133regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37794926
134regulation of mitotic spindle checkpoint (GO:1903504)2.37794926
135microtubule organizing center organization (GO:0031023)2.36986284
136metaphase plate congression (GO:0051310)2.36570607
137regulation of timing of cell differentiation (GO:0048505)2.36508864
138telomere maintenance via telomerase (GO:0007004)2.34961874
139tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.34920791
140RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.34920791
141mitotic sister chromatid cohesion (GO:0007064)2.34340845
142centriole assembly (GO:0098534)2.33659905
143ER overload response (GO:0006983)2.31444199
144exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.31081130
145establishment of chromosome localization (GO:0051303)2.30638294
146transcription elongation from RNA polymerase II promoter (GO:0006368)2.29821489
147intra-S DNA damage checkpoint (GO:0031573)2.28193494
148DNA replication-independent nucleosome assembly (GO:0006336)2.28119498
149DNA replication-independent nucleosome organization (GO:0034724)2.28119498
150viral mRNA export from host cell nucleus (GO:0046784)2.28105231
151regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.27676914
152somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.27159740
153isotype switching (GO:0045190)2.27159740
154somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.27159740
155DNA-templated transcription, elongation (GO:0006354)2.25317435
156tRNA processing (GO:0008033)2.24324867
157histone mRNA metabolic process (GO:0008334)2.23029352
158regulation of development, heterochronic (GO:0040034)2.22692336
159microtubule polymerization or depolymerization (GO:0031109)2.22660106
160regulation of mRNA splicing, via spliceosome (GO:0048024)2.22322045
161UTP biosynthetic process (GO:0006228)2.19959267
162V(D)J recombination (GO:0033151)2.19148916
163protein K63-linked deubiquitination (GO:0070536)2.18506022
164maturation of 5.8S rRNA (GO:0000460)2.18168646
165histone exchange (GO:0043486)2.18043006
166replication fork processing (GO:0031297)2.17798184
167DNA-templated transcription, termination (GO:0006353)2.17540095
168GPI anchor biosynthetic process (GO:0006506)2.17432378
169DNA double-strand break processing (GO:0000729)2.14170494
170mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.13126082
171somite development (GO:0061053)2.12571547
172positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.12546378
173guanosine-containing compound biosynthetic process (GO:1901070)2.10907625
174tRNA methylation (GO:0030488)2.10577815
175regulation of nuclear cell cycle DNA replication (GO:0033262)2.09783850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02946478
2RBPJ_22232070_ChIP-Seq_NCS_Mouse2.96800640
3GBX2_23144817_ChIP-Seq_PC3_Human2.84606743
4E2F7_22180533_ChIP-Seq_HELA_Human2.80966326
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.75635010
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66810836
7FUS_26573619_Chip-Seq_HEK293_Human2.62697968
8ZNF274_21170338_ChIP-Seq_K562_Hela2.60657216
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.50473515
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.32593496
11ELK1_19687146_ChIP-ChIP_HELA_Human2.32030462
12TAF15_26573619_Chip-Seq_HEK293_Human2.31462830
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22766638
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.19219994
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.17272354
16EWS_26573619_Chip-Seq_HEK293_Human2.15009898
17PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05610268
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99416204
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.94985630
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92314968
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91462958
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90206424
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81793021
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77294863
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.77241641
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76764856
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75953143
28VDR_23849224_ChIP-Seq_CD4+_Human1.71378678
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71002294
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69223467
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.66592977
32CBP_20019798_ChIP-Seq_JUKART_Human1.66592977
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66321013
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65687283
35VDR_22108803_ChIP-Seq_LS180_Human1.63452189
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63241543
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62405095
38BP1_19119308_ChIP-ChIP_Hs578T_Human1.61922387
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60993045
40P300_19829295_ChIP-Seq_ESCs_Human1.60163963
41IRF1_19129219_ChIP-ChIP_H3396_Human1.59496480
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56866328
43FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56529476
44STAT3_23295773_ChIP-Seq_U87_Human1.55301456
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55169109
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.55041160
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.52720977
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52670385
49ER_23166858_ChIP-Seq_MCF-7_Human1.52053567
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49524424
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49319297
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.49091069
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49045285
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48943041
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.46876203
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.46706198
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.45665930
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.45594101
59TCF4_23295773_ChIP-Seq_U87_Human1.45407343
60E2F1_18555785_Chip-Seq_ESCs_Mouse1.43557552
61IGF1R_20145208_ChIP-Seq_DFB_Human1.42931016
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.42181051
63SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41658433
64P53_22387025_ChIP-Seq_ESCs_Mouse1.41604096
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40982846
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.40846778
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39443185
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.38383774
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38234218
70STAT3_18555785_Chip-Seq_ESCs_Mouse1.37499482
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36800926
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.36208136
73EZH2_22144423_ChIP-Seq_EOC_Human1.34926286
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34125640
75FOXP3_21729870_ChIP-Seq_TREG_Human1.33854690
76NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.33557135
77BCAT_22108803_ChIP-Seq_LS180_Human1.33348193
78AR_25329375_ChIP-Seq_VCAP_Human1.33208311
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.33195973
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33014487
81CREB1_15753290_ChIP-ChIP_HEK293T_Human1.32985849
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31557113
83P300_18555785_Chip-Seq_ESCs_Mouse1.31455924
84SOX2_19829295_ChIP-Seq_ESCs_Human1.31011205
85NANOG_19829295_ChIP-Seq_ESCs_Human1.31011205
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30355555
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29100769
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.28359333
89EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.28313118
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26370688
91TP53_22573176_ChIP-Seq_HFKS_Human1.25840569
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.25163082
93NMYC_18555785_Chip-Seq_ESCs_Mouse1.24995091
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24760424
95TP53_16413492_ChIP-PET_HCT116_Human1.24463739
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24136926
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.24069677
98SOX2_18555785_Chip-Seq_ESCs_Mouse1.23163464
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21922721
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21571734
101MYC_18555785_ChIP-Seq_MESCs_Mouse1.20835426
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.19318518
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18469807
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17887489
105TCF4_22108803_ChIP-Seq_LS180_Human1.17735725
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17461244
107FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17228440
108RUNX2_22187159_ChIP-Seq_PCA_Human1.17164198
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.16952337
110RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16011535
111SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15750961
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.14610060
113THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14283446
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13609513
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12127937
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.11341375
117ZFX_18555785_Chip-Seq_ESCs_Mouse1.11081397
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10590893
119RNF2_27304074_Chip-Seq_NSC_Mouse1.10567349
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.10154650
121OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09554033
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.09007632
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08111753
124TP63_19390658_ChIP-ChIP_HaCaT_Human1.07577077
125SMAD4_21799915_ChIP-Seq_A2780_Human1.07319552
126CTCF_18555785_Chip-Seq_ESCs_Mouse1.07284129
127TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05067814
128KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04990626
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04707867
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04707867
131SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04522450
132MYC_18940864_ChIP-ChIP_HL60_Human1.03851850
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.03357616
134CBX2_27304074_Chip-Seq_ESCs_Mouse1.02818130
135TAL1_26923725_Chip-Seq_HPCs_Mouse1.02784058
136PU1_27457419_Chip-Seq_LIVER_Mouse1.00978015
137MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00581953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.33102637
2MP0001188_hyperpigmentation3.08969613
3MP0003787_abnormal_imprinting3.02512297
4MP0003880_abnormal_central_pattern2.64228518
5MP0008057_abnormal_DNA_replication2.63297499
6MP0004043_abnormal_pH_regulation2.56310204
7MP0008877_abnormal_DNA_methylation2.47189788
8MP0008058_abnormal_DNA_repair2.29036828
9MP0005171_absent_coat_pigmentation2.28180833
10MP0004885_abnormal_endolymph2.27222246
11MP0009697_abnormal_copulation2.03906167
12MP0002234_abnormal_pharynx_morphology2.00647772
13MP0006072_abnormal_retinal_apoptosis1.98336293
14MP0010094_abnormal_chromosome_stability1.97619308
15MP0001529_abnormal_vocalization1.96840245
16MP0000015_abnormal_ear_pigmentation1.96206038
17MP0000427_abnormal_hair_cycle1.93878390
18MP0000566_synostosis1.91882648
19MP0003136_yellow_coat_color1.89641529
20MP0003121_genomic_imprinting1.89167228
21MP0005409_darkened_coat_color1.88945189
22MP0001986_abnormal_taste_sensitivity1.85993018
23MP0005646_abnormal_pituitary_gland1.84655089
24MP0002837_dystrophic_cardiac_calcinosis1.80347899
25MP0005187_abnormal_penis_morphology1.80324967
26MP0002102_abnormal_ear_morphology1.71448549
27MP0000647_abnormal_sebaceous_gland1.62106863
28MP0010386_abnormal_urinary_bladder1.57774531
29MP0003693_abnormal_embryo_hatching1.55800221
30MP0001905_abnormal_dopamine_level1.54840316
31MP0005379_endocrine/exocrine_gland_phen1.52894191
32MP0003195_calcinosis1.51764539
33MP0002233_abnormal_nose_morphology1.46374823
34MP0003786_premature_aging1.44240255
35MP0004215_abnormal_myocardial_fiber1.38630504
36MP0008789_abnormal_olfactory_epithelium1.36011109
37MP0002938_white_spotting1.35315353
38MP0003077_abnormal_cell_cycle1.34574926
39MP0001485_abnormal_pinna_reflex1.34041931
40MP0002277_abnormal_respiratory_mucosa1.31584174
41MP0008932_abnormal_embryonic_tissue1.31425406
42MP0002095_abnormal_skin_pigmentation1.30814202
43MP0000631_abnormal_neuroendocrine_gland1.29620687
44MP0008007_abnormal_cellular_replicative1.27346924
45MP0003183_abnormal_peptide_metabolism1.27293493
46MP0003111_abnormal_nucleus_morphology1.24892563
47MP0004484_altered_response_of1.24878497
48MP0006276_abnormal_autonomic_nervous1.24293216
49MP0000372_irregular_coat_pigmentation1.23563698
50MP0000778_abnormal_nervous_system1.22505710
51MP0002272_abnormal_nervous_system1.22326541
52MP0003635_abnormal_synaptic_transmissio1.22126988
53MP0002184_abnormal_innervation1.21765564
54MP0004859_abnormal_synaptic_plasticity1.19573656
55MP0004145_abnormal_muscle_electrophysio1.19491021
56MP0005253_abnormal_eye_physiology1.17876178
57MP0008995_early_reproductive_senescence1.17848097
58MP0004742_abnormal_vestibular_system1.17612665
59MP0005645_abnormal_hypothalamus_physiol1.16292803
60MP0002009_preneoplasia1.15201120
61MP0004134_abnormal_chest_morphology1.13415163
62MP0005671_abnormal_response_to1.12939017
63MP0005394_taste/olfaction_phenotype1.12295525
64MP0005499_abnormal_olfactory_system1.12295525
65MP0002735_abnormal_chemical_nociception1.12279090
66MP0002638_abnormal_pupillary_reflex1.10659082
67MP0003122_maternal_imprinting1.09950539
68MP0004133_heterotaxia1.09576950
69MP0002653_abnormal_ependyma_morphology1.09464767
70MP0003137_abnormal_impulse_conducting1.09346813
71MP0005551_abnormal_eye_electrophysiolog1.09069942
72MP0004924_abnormal_behavior1.08197236
73MP0005386_behavior/neurological_phenoty1.08197236
74MP0000920_abnormal_myelination1.08147694
75MP0004381_abnormal_hair_follicle1.08144931
76MP0008872_abnormal_physiological_respon1.07305363
77MP0009745_abnormal_behavioral_response1.05661645
78MP0003950_abnormal_plasma_membrane1.04852376
79MP0001293_anophthalmia1.04837405
80MP0005075_abnormal_melanosome_morpholog1.04699423
81MP0001984_abnormal_olfaction1.04561619
82MP0002876_abnormal_thyroid_physiology1.03409051
83MP0006035_abnormal_mitochondrial_morpho1.03218994
84MP0004142_abnormal_muscle_tone1.03182439
85MP0002736_abnormal_nociception_after1.01783565
86MP0004957_abnormal_blastocyst_morpholog1.01272129
87MP0003567_abnormal_fetal_cardiomyocyte1.01060210
88MP0002396_abnormal_hematopoietic_system0.98817110
89MP0001486_abnormal_startle_reflex0.98621879
90MP0001963_abnormal_hearing_physiology0.97208018
91MP0003011_delayed_dark_adaptation0.96681919
92MP0005174_abnormal_tail_pigmentation0.96255513
93MP0003763_abnormal_thymus_physiology0.96224994
94MP0003890_abnormal_embryonic-extraembry0.96057776
95MP0002572_abnormal_emotion/affect_behav0.95181991
96MP0009780_abnormal_chondrocyte_physiolo0.94933986
97MP0001970_abnormal_pain_threshold0.94759283
98MP0000516_abnormal_urinary_system0.94730250
99MP0005367_renal/urinary_system_phenotyp0.94730250
100MP0002751_abnormal_autonomic_nervous0.93406418
101MP0000026_abnormal_inner_ear0.92758073
102MP0009379_abnormal_foot_pigmentation0.91285060
103MP0002163_abnormal_gland_morphology0.90979754
104MP0002882_abnormal_neuron_morphology0.90752946
105MP0002733_abnormal_thermal_nociception0.90337997
106MP0001968_abnormal_touch/_nociception0.89372878
107MP0004085_abnormal_heartbeat0.88211694
108MP0003755_abnormal_palate_morphology0.86813516
109MP0004811_abnormal_neuron_physiology0.85888701
110MP0003937_abnormal_limbs/digits/tail_de0.84712432
111MP0002067_abnormal_sensory_capabilities0.84005370
112MP0004084_abnormal_cardiac_muscle0.83161929
113MP0001177_atelectasis0.82885470
114MP0004270_analgesia0.82880988
115MP0002064_seizures0.82436243
116MP0002210_abnormal_sex_determination0.81202249
117MP0002160_abnormal_reproductive_system0.80861217
118MP0004147_increased_porphyrin_level0.80554462
119MP0001324_abnormal_eye_pigmentation0.80548242
120MP0003119_abnormal_digestive_system0.79181881
121MP0008775_abnormal_heart_ventricle0.78387818
122MP0002557_abnormal_social/conspecific_i0.77232094
123MP0000613_abnormal_salivary_gland0.76875862
124MP0005195_abnormal_posterior_eye0.76862133
125MP0000049_abnormal_middle_ear0.76531952
126MP0002177_abnormal_outer_ear0.76319677
127MP0001286_abnormal_eye_development0.75483674
128MP0009046_muscle_twitch0.75243691
129MP0001501_abnormal_sleep_pattern0.74115837
130MP0002693_abnormal_pancreas_physiology0.73945290
131MP0003724_increased_susceptibility_to0.71659263
132MP0005408_hypopigmentation0.70766140
133MP0002734_abnormal_mechanical_nocicepti0.69328461
134MP0000569_abnormal_digit_pigmentation0.68961348
135MP0001929_abnormal_gametogenesis0.66781525
136MP0002063_abnormal_learning/memory/cond0.66680264
137MP0005389_reproductive_system_phenotype0.66449742
138MP0001186_pigmentation_phenotype0.66439775
139MP0002752_abnormal_somatic_nervous0.65393186
140MP0003938_abnormal_ear_development0.64773440
141MP0001919_abnormal_reproductive_system0.63850165
142MP0005423_abnormal_somatic_nervous0.62947367

Predicted human phenotypes

RankGene SetZ-score
1Broad-based gait (HP:0002136)4.05405840
2Long nose (HP:0003189)3.19290885
3Acute necrotizing encephalopathy (HP:0006965)3.18575723
4Progressive inability to walk (HP:0002505)3.17548110
5Medial flaring of the eyebrow (HP:0010747)2.92441000
6Volvulus (HP:0002580)2.89003667
7Abnormal hair whorl (HP:0010721)2.81138237
8Progressive macrocephaly (HP:0004481)2.77163087
9Chromsome breakage (HP:0040012)2.76042669
10Abnormality of the labia minora (HP:0012880)2.75004525
11Hypothermia (HP:0002045)2.69954355
12Mitochondrial inheritance (HP:0001427)2.68199810
13Inability to walk (HP:0002540)2.67104200
14Gaze-evoked nystagmus (HP:0000640)2.64213375
15Neoplasm of the oral cavity (HP:0100649)2.62946440
16Abnormal mitochondria in muscle tissue (HP:0008316)2.59416946
17Drooling (HP:0002307)2.59396972
18Congenital primary aphakia (HP:0007707)2.55655042
19Nephrogenic diabetes insipidus (HP:0009806)2.53470291
20Pancreatic fibrosis (HP:0100732)2.52882996
21Tubulointerstitial nephritis (HP:0001970)2.51106746
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.50385441
23Gait imbalance (HP:0002141)2.49538195
24True hermaphroditism (HP:0010459)2.47185071
25Febrile seizures (HP:0002373)2.44048092
26Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41944783
27Degeneration of the lateral corticospinal tracts (HP:0002314)2.41944783
28Renal Fanconi syndrome (HP:0001994)2.35170611
29Lissencephaly (HP:0001339)2.34587686
30Excessive salivation (HP:0003781)2.31913542
31Reduced antithrombin III activity (HP:0001976)2.31435888
32Renal cortical cysts (HP:0000803)2.29956480
33Molar tooth sign on MRI (HP:0002419)2.28063757
34Abnormality of midbrain morphology (HP:0002418)2.28063757
35Amyotrophic lateral sclerosis (HP:0007354)2.26755240
36Increased hepatocellular lipid droplets (HP:0006565)2.26652971
37Increased CSF lactate (HP:0002490)2.25597160
38Focal motor seizures (HP:0011153)2.25452651
39Median cleft lip (HP:0000161)2.24163619
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.24135587
41Absent/shortened dynein arms (HP:0200106)2.24135587
42Cystic liver disease (HP:0006706)2.23792905
43Chronic hepatic failure (HP:0100626)2.22547139
44Abolished electroretinogram (ERG) (HP:0000550)2.22185137
45Cupped ear (HP:0000378)2.21716821
46Pachygyria (HP:0001302)2.21216676
47Aplasia/Hypoplasia of the tibia (HP:0005772)2.18998107
483-Methylglutaconic aciduria (HP:0003535)2.17606253
49Colon cancer (HP:0003003)2.15988108
50Aplasia/Hypoplasia of the tongue (HP:0010295)2.13636152
51Genital tract atresia (HP:0001827)2.13215624
52Abnormality of DNA repair (HP:0003254)2.13047785
53Absent speech (HP:0001344)2.11832225
54Protruding tongue (HP:0010808)2.11627265
55Abnormality of the corticospinal tract (HP:0002492)2.11614889
56Postaxial hand polydactyly (HP:0001162)2.10899776
57Type II lissencephaly (HP:0007260)2.10349830
58Microvesicular hepatic steatosis (HP:0001414)2.09125724
59Pancreatic cysts (HP:0001737)2.07737626
60Congenital stationary night blindness (HP:0007642)2.07332240
61Abnormal respiratory motile cilium morphology (HP:0005938)2.07207031
62Abnormal respiratory epithelium morphology (HP:0012253)2.07207031
63Abnormality of chromosome stability (HP:0003220)2.05416590
64Acute encephalopathy (HP:0006846)2.05229506
65Hepatocellular necrosis (HP:0001404)2.05112272
66Nephroblastoma (Wilms tumor) (HP:0002667)2.05104801
67Poor coordination (HP:0002370)2.03752840
68Methylmalonic acidemia (HP:0002912)2.03449128
69Conical tooth (HP:0000698)2.03182725
70Type I transferrin isoform profile (HP:0003642)2.02348057
71Preaxial hand polydactyly (HP:0001177)2.02329464
72Vaginal atresia (HP:0000148)2.01204159
73Nephronophthisis (HP:0000090)2.01025530
74Bifid tongue (HP:0010297)1.99989000
75Aplastic anemia (HP:0001915)1.99005021
76Attenuation of retinal blood vessels (HP:0007843)1.98983934
77Abnormality of lateral ventricle (HP:0030047)1.98701632
78Intestinal atresia (HP:0011100)1.97588437
79Abnormality of the preputium (HP:0100587)1.96772143
80Autoamputation (HP:0001218)1.96328422
81Embryonal renal neoplasm (HP:0011794)1.96019390
82Congenital, generalized hypertrichosis (HP:0004540)1.94875034
83Thyroid-stimulating hormone excess (HP:0002925)1.94596683
84Birth length less than 3rd percentile (HP:0003561)1.94519088
85Congenital hepatic fibrosis (HP:0002612)1.94151552
86Parakeratosis (HP:0001036)1.93361389
87Short tibia (HP:0005736)1.92825444
88Duplicated collecting system (HP:0000081)1.92535778
89Exotropia (HP:0000577)1.91166778
90Severe combined immunodeficiency (HP:0004430)1.90353190
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.89474385
92Abnormality of the columella (HP:0009929)1.88858600
93Narrow forehead (HP:0000341)1.87788848
94Optic disc pallor (HP:0000543)1.87482973
95Abnormality of the renal collecting system (HP:0004742)1.86908191
96Abnormal ciliary motility (HP:0012262)1.85716395
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83658110
98Bile duct proliferation (HP:0001408)1.82565241
99Abnormal biliary tract physiology (HP:0012439)1.82565241
100Abnormality of the renal medulla (HP:0100957)1.81343036
101Postaxial foot polydactyly (HP:0001830)1.81044685
102Metaphyseal dysplasia (HP:0100255)1.80132823
103Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.80089178
104Abnormality of incisor morphology (HP:0011063)1.79628680
105Prominent nasal bridge (HP:0000426)1.79506940
106Adrenal hypoplasia (HP:0000835)1.79446600
107Sclerocornea (HP:0000647)1.79281335
108Abnormality of renal resorption (HP:0011038)1.79113832
109Sloping forehead (HP:0000340)1.78501971
110Patchy hypopigmentation of hair (HP:0011365)1.78005809
111White forelock (HP:0002211)1.77742267
112Congenital sensorineural hearing impairment (HP:0008527)1.76770520
113Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76202546
114Hepatoblastoma (HP:0002884)1.75869213
115Male pseudohermaphroditism (HP:0000037)1.74388390
116Aplasia/Hypoplasia of the lens (HP:0008063)1.72466594
117Atonic seizures (HP:0010819)1.72422948
118Bulbous nose (HP:0000414)1.71351858
119Fair hair (HP:0002286)1.70897103
120Specific learning disability (HP:0001328)1.70884561
121Hypochromic microcytic anemia (HP:0004840)1.69906247
122Abnormal rod and cone electroretinograms (HP:0008323)1.69555815
123Preaxial foot polydactyly (HP:0001841)1.68974268
124Tachypnea (HP:0002789)1.68608654
125Abnormal drinking behavior (HP:0030082)1.67577945
126Polydipsia (HP:0001959)1.67577945
127Leukodystrophy (HP:0002415)1.67254777
128Abnormal respiratory motile cilium physiology (HP:0012261)1.65561663
129Tubular atrophy (HP:0000092)1.65444561
130Aplasia/hypoplasia of the uterus (HP:0008684)1.64316451
131Aganglionic megacolon (HP:0002251)1.64006931
132Astigmatism (HP:0000483)1.63568577
133Widely spaced teeth (HP:0000687)1.63267214
134Gastroesophageal reflux (HP:0002020)1.63100587
135Abnormality of the septum pellucidum (HP:0007375)1.59937205
136Submucous cleft hard palate (HP:0000176)1.59791394
137Anencephaly (HP:0002323)1.59646130
138Asplenia (HP:0001746)1.59197795
139Septo-optic dysplasia (HP:0100842)1.59094516
14011 pairs of ribs (HP:0000878)1.58459429
141Abnormality of the renal cortex (HP:0011035)1.58192075
142Hepatic necrosis (HP:0002605)1.58030877
143Aplasia cutis congenita (HP:0001057)1.57002504
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56946074
145Abnormal protein glycosylation (HP:0012346)1.56880067
146Abnormal glycosylation (HP:0012345)1.56880067
147Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.56880067
148Abnormal protein N-linked glycosylation (HP:0012347)1.56880067
149Thyroiditis (HP:0100646)1.56691180
150Gastrointestinal atresia (HP:0002589)1.56222828
151Exercise intolerance (HP:0003546)1.56021295
152Hyperventilation (HP:0002883)1.55687157
153Lipid accumulation in hepatocytes (HP:0006561)1.54590611
154Absent septum pellucidum (HP:0001331)1.53785232
155Ectopic kidney (HP:0000086)1.53375965

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.51324671
2STK163.20692704
3TAOK32.80033765
4SRPK12.54511946
5MAP4K22.53316429
6MKNK12.35608476
7PNCK2.24241992
8ZAK2.23149005
9TRIM282.18431950
10BMPR1B2.15434294
11NUAK12.15010134
12VRK12.12825735
13TNIK2.12059235
14MKNK22.05290032
15MST41.97241279
16MAP3K41.85112683
17EIF2AK11.80748612
18CDC71.80448281
19BRD41.70097732
20EPHA41.69930752
21TXK1.68791841
22STK391.66649748
23TSSK61.62919706
24NEK61.57839940
25EIF2AK31.56110168
26OXSR11.54989974
27IRAK41.54507441
28BCR1.48007668
29AKT31.47562967
30PLK21.42746061
31TLK11.40159117
32BMPR21.38736900
33MARK11.36587810
34MAP3K121.33853414
35PLK31.33621545
36MAP2K71.32936603
37PBK1.23808342
38PINK11.23155661
39TGFBR21.22909255
40INSRR1.15780200
41CDK81.15676446
42YES11.13746825
43MAPK131.13240664
44PLK41.13046021
45DMPK1.12836987
46CDC42BPA1.12185156
47PAK31.10529347
48BUB11.10078042
49CDK31.09832356
50MAP3K141.09235587
51ADRBK21.05331908
52BRAF1.04979917
53CCNB11.04217984
54LATS11.01602171
55IRAK31.00020609
56FRK0.97983484
57ERBB30.97237149
58IRAK20.95625069
59EIF2AK20.95600310
60IRAK10.92764476
61MINK10.92583264
62RPS6KA50.90777806
63PASK0.88044011
64WEE10.86315577
65GRK70.86204754
66TEC0.86184245
67MAPKAPK50.84164774
68DYRK30.83005725
69ATR0.80119465
70PRPF4B0.78211113
71CSNK1A1L0.77753957
72PRKCG0.74778587
73NME10.74600209
74RPS6KA40.74446251
75SIK30.73019528
76STK38L0.72902975
77ATM0.70670889
78WNK10.70123880
79STK30.68552413
80CSNK1G30.67569681
81NTRK30.67453330
82GRK50.66449819
83PKN10.65161064
84TTK0.64905092
85CDK190.63499787
86MAP3K60.63367883
87PRKCE0.61154630
88NTRK20.60305201
89ADRBK10.59770423
90PRKCQ0.59069168
91PLK10.58953796
92TNK20.56901703
93CHEK20.55821345
94DYRK20.54865228
95WNK40.53970874
96CLK10.53293539
97SGK20.53116923
98CAMK2B0.51749515
99AURKB0.51291920
100CAMKK20.51287054
101ABL10.51142184
102EPHA30.50291611
103BRSK20.49565211
104PIK3CA0.47222440
105RIPK40.46975784
106CHEK10.46837759
107ROCK10.46319050
108SGK2230.45701124
109SGK4940.45701124
110WNK30.45030678
111DYRK1A0.44876438
112CSNK2A20.44015095
113PRKG10.43854625
114MAPK150.43637201
115CSNK2A10.42564295
116PRKACA0.42300526
117DAPK20.41989002
118CSNK1E0.41543389
119CAMK2A0.41373959
120PRKACB0.41008245
121LCK0.40872034
122CAMK2D0.40786941
123JAK30.40010727
124NEK10.39619750
125KIT0.39413765
126ACVR1B0.38859178
127LYN0.38527108
128PHKG10.38441086
129PHKG20.38441086
130CSNK1G10.38228632
131OBSCN0.37561994
132CSNK1G20.36538428
133PRKCI0.36114847
134CSNK1D0.35419518
135CSNK1A10.35340221
136GRK10.35156678
137PRKDC0.35011175
138HCK0.34282092

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.77013165
2RNA polymerase_Homo sapiens_hsa030202.68652344
3Proteasome_Homo sapiens_hsa030502.52117959
4Non-homologous end-joining_Homo sapiens_hsa034502.51082500
5Oxidative phosphorylation_Homo sapiens_hsa001902.30260031
6Homologous recombination_Homo sapiens_hsa034402.26627587
7Basal transcription factors_Homo sapiens_hsa030222.21439353
8Mismatch repair_Homo sapiens_hsa034302.19929152
9Regulation of autophagy_Homo sapiens_hsa041402.18446419
10Propanoate metabolism_Homo sapiens_hsa006402.13781433
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.07552461
12Fanconi anemia pathway_Homo sapiens_hsa034602.06567034
13Nucleotide excision repair_Homo sapiens_hsa034202.02038711
14Spliceosome_Homo sapiens_hsa030402.00328457
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97811324
16DNA replication_Homo sapiens_hsa030301.81319440
17RNA degradation_Homo sapiens_hsa030181.79828211
18Parkinsons disease_Homo sapiens_hsa050121.68406611
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.67805997
20Ribosome_Homo sapiens_hsa030101.62403773
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.62393458
22Butanoate metabolism_Homo sapiens_hsa006501.59921816
23SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56145034
24Alzheimers disease_Homo sapiens_hsa050101.49682256
25Huntingtons disease_Homo sapiens_hsa050161.43420722
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43012643
27mRNA surveillance pathway_Homo sapiens_hsa030151.36758275
28Nicotine addiction_Homo sapiens_hsa050331.36420954
29Base excision repair_Homo sapiens_hsa034101.36306091
30Pyrimidine metabolism_Homo sapiens_hsa002401.36009953
31RNA transport_Homo sapiens_hsa030131.31933720
32Olfactory transduction_Homo sapiens_hsa047401.30938957
33Insulin secretion_Homo sapiens_hsa049111.29391773
34Nitrogen metabolism_Homo sapiens_hsa009101.29367354
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28826497
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28125850
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25639416
38Autoimmune thyroid disease_Homo sapiens_hsa053201.15820503
39Allograft rejection_Homo sapiens_hsa053301.14730737
40Type I diabetes mellitus_Homo sapiens_hsa049401.14723829
41Collecting duct acid secretion_Homo sapiens_hsa049661.14030765
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13689541
43Cell cycle_Homo sapiens_hsa041101.13629281
44Purine metabolism_Homo sapiens_hsa002301.12473548
45Phototransduction_Homo sapiens_hsa047441.12010141
46Sphingolipid metabolism_Homo sapiens_hsa006001.07995371
47Serotonergic synapse_Homo sapiens_hsa047261.07932607
48Rheumatoid arthritis_Homo sapiens_hsa053231.06281892
49Ether lipid metabolism_Homo sapiens_hsa005651.03260600
50Peroxisome_Homo sapiens_hsa041461.02475320
51Graft-versus-host disease_Homo sapiens_hsa053321.01238304
52Primary immunodeficiency_Homo sapiens_hsa053401.00672737
53Vibrio cholerae infection_Homo sapiens_hsa051100.96451513
54Salivary secretion_Homo sapiens_hsa049700.95532523
55Circadian rhythm_Homo sapiens_hsa047100.95164223
56Taste transduction_Homo sapiens_hsa047420.94192679
57Hematopoietic cell lineage_Homo sapiens_hsa046400.86220926
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85190963
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83933263
60Caffeine metabolism_Homo sapiens_hsa002320.83837687
61ABC transporters_Homo sapiens_hsa020100.80624157
62Epstein-Barr virus infection_Homo sapiens_hsa051690.80608818
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78094847
64Asthma_Homo sapiens_hsa053100.76901030
65Renin secretion_Homo sapiens_hsa049240.76462161
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74435814
67Steroid biosynthesis_Homo sapiens_hsa001000.73097999
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72940159
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.72745987
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.72443168
71Systemic lupus erythematosus_Homo sapiens_hsa053220.72408041
72Selenocompound metabolism_Homo sapiens_hsa004500.70412371
73beta-Alanine metabolism_Homo sapiens_hsa004100.69754061
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68829933
75Alcoholism_Homo sapiens_hsa050340.68202676
76Morphine addiction_Homo sapiens_hsa050320.68125256
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67617382
78Amphetamine addiction_Homo sapiens_hsa050310.66425795
79Arachidonic acid metabolism_Homo sapiens_hsa005900.65971636
80Long-term depression_Homo sapiens_hsa047300.63558994
81Phagosome_Homo sapiens_hsa041450.61492455
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61121913
83Cholinergic synapse_Homo sapiens_hsa047250.60558835
84Glutamatergic synapse_Homo sapiens_hsa047240.59068981
85Long-term potentiation_Homo sapiens_hsa047200.58676964
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.57756740
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57365911
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56988850
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55669055
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.55288216
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55105269
92Measles_Homo sapiens_hsa051620.54922808
93Circadian entrainment_Homo sapiens_hsa047130.54031469
94Herpes simplex infection_Homo sapiens_hsa051680.53126383
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52465886
96Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.51160251
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.50998629
98Antigen processing and presentation_Homo sapiens_hsa046120.49759968
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49322544
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49161650
101Tryptophan metabolism_Homo sapiens_hsa003800.48629475
102Dopaminergic synapse_Homo sapiens_hsa047280.48325638
103Fatty acid elongation_Homo sapiens_hsa000620.48191487
104Chemical carcinogenesis_Homo sapiens_hsa052040.48040298
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47752089
106T cell receptor signaling pathway_Homo sapiens_hsa046600.47613005
107Retinol metabolism_Homo sapiens_hsa008300.47189164
108Pancreatic secretion_Homo sapiens_hsa049720.46235753
109Oocyte meiosis_Homo sapiens_hsa041140.46177130
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.44778044
111Metabolic pathways_Homo sapiens_hsa011000.41653114
112Linoleic acid metabolism_Homo sapiens_hsa005910.40771914
113cAMP signaling pathway_Homo sapiens_hsa040240.38407730
114Axon guidance_Homo sapiens_hsa043600.37522150
115Calcium signaling pathway_Homo sapiens_hsa040200.37306014
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36335407
117p53 signaling pathway_Homo sapiens_hsa041150.36293873
118Gastric acid secretion_Homo sapiens_hsa049710.35423280
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34976276
120Viral carcinogenesis_Homo sapiens_hsa052030.33591368
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33365663
122Malaria_Homo sapiens_hsa051440.33253734
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33136390
124Wnt signaling pathway_Homo sapiens_hsa043100.32956150
125GABAergic synapse_Homo sapiens_hsa047270.32790239
126Cocaine addiction_Homo sapiens_hsa050300.32364700
127Oxytocin signaling pathway_Homo sapiens_hsa049210.31916630
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29890795
129Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29263204
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28713926
131Ovarian steroidogenesis_Homo sapiens_hsa049130.28639843
132N-Glycan biosynthesis_Homo sapiens_hsa005100.27722069
133TGF-beta signaling pathway_Homo sapiens_hsa043500.26370009
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25504847
135African trypanosomiasis_Homo sapiens_hsa051430.24908849
136Cardiac muscle contraction_Homo sapiens_hsa042600.24621465
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24451385
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24102339
139Prostate cancer_Homo sapiens_hsa052150.24044531
140Folate biosynthesis_Homo sapiens_hsa007900.21701031

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