NEMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.65014056
2mitotic chromosome condensation (GO:0007076)6.92074208
3nuclear pore organization (GO:0006999)6.78931737
4DNA unwinding involved in DNA replication (GO:0006268)6.78199864
5mitotic sister chromatid segregation (GO:0000070)6.06759881
6sister chromatid segregation (GO:0000819)5.95717362
7pore complex assembly (GO:0046931)5.83424081
8DNA strand elongation involved in DNA replication (GO:0006271)5.56313152
9mitotic sister chromatid cohesion (GO:0007064)5.52541320
10protein localization to chromosome, centromeric region (GO:0071459)5.40395237
11DNA strand elongation (GO:0022616)5.39176390
12protein localization to kinetochore (GO:0034501)5.29900962
13DNA topological change (GO:0006265)5.11949837
14telomere maintenance via semi-conservative replication (GO:0032201)5.01073821
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.75131194
16mitotic metaphase plate congression (GO:0007080)4.73709844
17DNA replication initiation (GO:0006270)4.71561474
18mitotic nuclear envelope disassembly (GO:0007077)4.65537756
19chromosome condensation (GO:0030261)4.47856021
20DNA replication checkpoint (GO:0000076)4.42608986
21mitotic recombination (GO:0006312)4.39226498
22telomere maintenance via recombination (GO:0000722)4.38974685
23membrane disassembly (GO:0030397)4.36930698
24nuclear envelope disassembly (GO:0051081)4.36930698
25regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.28619345
26metaphase plate congression (GO:0051310)4.20201752
27regulation of mitotic spindle organization (GO:0060236)4.14309112
28kinetochore organization (GO:0051383)4.09965106
29regulation of sister chromatid cohesion (GO:0007063)4.08527558
30regulation of translational fidelity (GO:0006450)4.05381744
31DNA duplex unwinding (GO:0032508)4.02605902
32positive regulation of chromosome segregation (GO:0051984)3.96401421
33regulation of spindle organization (GO:0090224)3.96295960
34DNA packaging (GO:0006323)3.88217745
35heterochromatin organization (GO:0070828)3.87666569
36DNA ligation (GO:0006266)3.87196227
37DNA geometric change (GO:0032392)3.86356210
38establishment of chromosome localization (GO:0051303)3.85559936
39DNA conformation change (GO:0071103)3.80780446
40chromosome segregation (GO:0007059)3.76559604
41meiotic chromosome segregation (GO:0045132)3.75613322
42regulation of chromosome segregation (GO:0051983)3.75322385
43establishment of integrated proviral latency (GO:0075713)3.68310113
44protein localization to chromosome (GO:0034502)3.68076657
45regulation of RNA export from nucleus (GO:0046831)3.67471614
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.63954246
47CENP-A containing nucleosome assembly (GO:0034080)3.63821698
48folic acid-containing compound biosynthetic process (GO:0009396)3.63726542
49regulation of centriole replication (GO:0046599)3.62607977
50DNA synthesis involved in DNA repair (GO:0000731)3.59268030
51chromatin remodeling at centromere (GO:0031055)3.50914425
52protein complex localization (GO:0031503)3.50590814
53negative regulation of chromosome segregation (GO:0051985)3.50358920
54non-recombinational repair (GO:0000726)3.50286121
55double-strand break repair via nonhomologous end joining (GO:0006303)3.50286121
56cellular protein complex localization (GO:0034629)3.47342284
57nuclear envelope organization (GO:0006998)3.45667185
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.45655982
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.45655982
60positive regulation of mitotic sister chromatid separation (GO:1901970)3.45655982
61spindle checkpoint (GO:0031577)3.40271439
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35932207
63regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.35932207
64V(D)J recombination (GO:0033151)3.34739142
65regulation of mitotic sister chromatid separation (GO:0010965)3.31523739
66regulation of mitotic sister chromatid segregation (GO:0033047)3.31523739
67regulation of sister chromatid segregation (GO:0033045)3.31523739
68negative regulation of mitotic sister chromatid separation (GO:2000816)3.29792132
69negative regulation of sister chromatid segregation (GO:0033046)3.29792132
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29792132
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.29792132
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29792132
73DNA replication-independent nucleosome organization (GO:0034724)3.29735169
74DNA replication-independent nucleosome assembly (GO:0006336)3.29735169
75regulation of DNA endoreduplication (GO:0032875)3.28121291
76regulation of centrosome cycle (GO:0046605)3.26419098
77mitotic spindle checkpoint (GO:0071174)3.25400546
78telomere maintenance via telomere lengthening (GO:0010833)3.23773048
79mitotic spindle assembly checkpoint (GO:0007094)3.20973393
80purine nucleobase biosynthetic process (GO:0009113)3.18911098
81spindle assembly checkpoint (GO:0071173)3.15865617
82IMP biosynthetic process (GO:0006188)3.15828961
83chromatin assembly or disassembly (GO:0006333)3.15204020
84pre-miRNA processing (GO:0031054)3.11984913
85ATP-dependent chromatin remodeling (GO:0043044)3.11811146
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.10092926
87formation of translation preinitiation complex (GO:0001731)3.09582550
88regulation of nucleobase-containing compound transport (GO:0032239)3.07274882
89mitotic G2/M transition checkpoint (GO:0044818)3.06444364
90nucleobase biosynthetic process (GO:0046112)3.05502946
91regulation of histone H3-K9 methylation (GO:0051570)3.04060645
92positive regulation of cell cycle checkpoint (GO:1901978)3.03705559
93mitotic cell cycle (GO:0000278)3.00280224
94spliceosomal tri-snRNP complex assembly (GO:0000244)2.99221454
95sister chromatid cohesion (GO:0007062)2.97086911
96telomere maintenance (GO:0000723)2.94584040
97IMP metabolic process (GO:0046040)2.94531606
98kinetochore assembly (GO:0051382)2.94326575
99protein export from nucleus (GO:0006611)2.94021791
100negative regulation of histone methylation (GO:0031061)2.93326173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.72487844
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.77800459
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.13846806
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.40614346
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.36908098
6AR_21909140_ChIP-Seq_LNCAP_Human3.18814646
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82097617
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74601108
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.73903741
10KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.68983002
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47420261
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36799237
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35127988
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.14330483
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08180560
16MYC_22102868_ChIP-Seq_BL_Human2.06045506
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05669181
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02864112
19E2F7_22180533_ChIP-Seq_HELA_Human12.3111143
20MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98780051
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87452410
22XRN2_22483619_ChIP-Seq_HELA_Human1.85480534
23POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84820606
24ZFX_18555785_ChIP-Seq_MESCs_Mouse1.75878837
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.74287707
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70271412
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62575169
28DCP1A_22483619_ChIP-Seq_HELA_Human1.60526836
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60136608
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59093326
31TTF2_22483619_ChIP-Seq_HELA_Human1.56913430
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56776416
33CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55622332
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52204911
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.47045650
36E2F1_18555785_ChIP-Seq_MESCs_Mouse1.46902258
37CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.46195376
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.45103987
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43980531
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40601941
41E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.39155397
42KDM5A_27292631_Chip-Seq_BREAST_Human1.37790835
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34701340
44ELK1_19687146_ChIP-ChIP_HELA_Human1.34558796
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.34374888
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30841390
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28221941
48FOXP3_21729870_ChIP-Seq_TREG_Human1.28113369
49CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.26562836
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25925408
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25552549
52PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25149961
53TFEB_21752829_ChIP-Seq_HELA_Human1.23699308
54ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21321044
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20340655
56TP63_19390658_ChIP-ChIP_HaCaT_Human1.20128237
57CIITA_25753668_ChIP-Seq_RAJI_Human1.15911441
58GABP_19822575_ChIP-Seq_HepG2_Human1.13383174
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10659245
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06581972
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06039922
62GABP_17652178_ChIP-ChIP_JURKAT_Human1.05219223
63NANOG_21062744_ChIP-ChIP_HESCs_Human1.04766664
64CHD1_26751641_Chip-Seq_LNCaP_Human1.03290675
65CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03285221
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01764695
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99468763
68VDR_23849224_ChIP-Seq_CD4+_Human0.96527853
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95241284
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92900362
71WT1_19549856_ChIP-ChIP_CCG9911_Human0.91334531
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90257018
73ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89734001
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88863850
75SOX17_20123909_ChIP-Seq_XEN_Mouse0.88624736
76KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88595671
77KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88595671
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88595671
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85450148
80NCOR1_26117541_ChIP-Seq_K562_Human0.83978655
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83730909
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.82513621
83POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81666823
84VDR_21846776_ChIP-Seq_THP-1_Human0.81111981
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80594239
86ELF1_17652178_ChIP-ChIP_JURKAT_Human0.80453720
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80254401
88ZNF263_19887448_ChIP-Seq_K562_Human0.79073394
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78951597
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78701609
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78606599
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78531169
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.76237219
94CLOCK_20551151_ChIP-Seq_293T_Human0.75089229
95KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73402391
96PKCTHETA_26484144_Chip-Seq_BREAST_Human0.71439305
97BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70918132
98NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69854401
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.68944983
100EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.68677426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.30289720
2MP0008057_abnormal_DNA_replication5.00579119
3MP0003111_abnormal_nucleus_morphology4.80084328
4MP0003693_abnormal_embryo_hatching4.28946403
5MP0003077_abnormal_cell_cycle3.82519598
6MP0004957_abnormal_blastocyst_morpholog3.78367140
7MP0008058_abnormal_DNA_repair2.83073932
8MP0008932_abnormal_embryonic_tissue2.81082616
9MP0010307_abnormal_tumor_latency2.65710232
10MP0010352_gastrointestinal_tract_polyps2.63713906
11MP0002009_preneoplasia2.61067540
12MP0002396_abnormal_hematopoietic_system2.50711227
13MP0008007_abnormal_cellular_replicative2.48970981
14MP0002877_abnormal_melanocyte_morpholog2.45554797
15MP0000350_abnormal_cell_proliferation2.29969386
16MP0005076_abnormal_cell_differentiation2.25275403
17MP0001730_embryonic_growth_arrest2.19808498
18MP0003705_abnormal_hypodermis_morpholog2.05531769
19MP0009697_abnormal_copulation1.91685642
20MP0005380_embryogenesis_phenotype1.89202384
21MP0001672_abnormal_embryogenesis/_devel1.89202384
22MP0004808_abnormal_hematopoietic_stem1.79773000
23MP0001697_abnormal_embryo_size1.76610802
24MP0003984_embryonic_growth_retardation1.71198289
25MP0002088_abnormal_embryonic_growth/wei1.64334335
26MP0009672_abnormal_birth_weight1.61817868
27MP0002080_prenatal_lethality1.60145417
28MP0004233_abnormal_muscle_weight1.57382476
29MP0003890_abnormal_embryonic-extraembry1.52069797
30MP0002085_abnormal_embryonic_tissue1.51227397
31MP0000313_abnormal_cell_death1.48870698
32MP0002084_abnormal_developmental_patter1.46287413
33MP0004185_abnormal_adipocyte_glucose1.43715813
34MP0002086_abnormal_extraembryonic_tissu1.39309253
35MP0004197_abnormal_fetal_growth/weight/1.37276088
36MP0003718_maternal_effect1.35137899
37MP0000490_abnormal_crypts_of1.29052122
38MP0010030_abnormal_orbit_morphology1.28825710
39MP0003941_abnormal_skin_development1.25162653
40MP0002697_abnormal_eye_size1.24902111
41MP0010234_abnormal_vibrissa_follicle1.23812594
42MP0005451_abnormal_body_composition1.23550901
43MP0002019_abnormal_tumor_incidence1.18560346
44MP0000428_abnormal_craniofacial_morphol1.18464268
45MP0001346_abnormal_lacrimal_gland1.18463554
46MP0003656_abnormal_erythrocyte_physiolo1.16543491
47MP0005621_abnormal_cell_physiology1.10701690
48MP0000537_abnormal_urethra_morphology1.08145102
49MP0000566_synostosis1.07494982
50MP0003315_abnormal_perineum_morphology1.07008136
51MP0003786_premature_aging1.03871015
52MP0001293_anophthalmia1.02339020
53MP0002092_abnormal_eye_morphology1.01750378
54MP0009703_decreased_birth_body1.01546458
55MP0003221_abnormal_cardiomyocyte_apopto1.00587453
56MP0003937_abnormal_limbs/digits/tail_de0.97498149
57MP0005384_cellular_phenotype0.96828735
58MP0000703_abnormal_thymus_morphology0.92457000
59MP0003566_abnormal_cell_adhesion0.90905689
60MP0002111_abnormal_tail_morphology0.86471166
61MP0001286_abnormal_eye_development0.84376115
62MP0001849_ear_inflammation0.83166445
63MP0000358_abnormal_cell_content/0.81700257
64MP0003567_abnormal_fetal_cardiomyocyte0.81532231
65MP0003453_abnormal_keratinocyte_physiol0.81220896
66MP0003763_abnormal_thymus_physiology0.80446304
67MP0002210_abnormal_sex_determination0.80310351
68MP0002006_tumorigenesis0.79641367
69MP0003943_abnormal_hepatobiliary_system0.77587113
70MP0004264_abnormal_extraembryonic_tissu0.76005275
71MP0001929_abnormal_gametogenesis0.75146259
72MP0009278_abnormal_bone_marrow0.73369584
73MP0001661_extended_life_span0.73347877
74MP0001915_intracranial_hemorrhage0.72570647
75MP0005501_abnormal_skin_physiology0.71956686
76MP0000432_abnormal_head_morphology0.71371008
77MP0009053_abnormal_anal_canal0.70158289
78MP0003935_abnormal_craniofacial_develop0.68245743
79MP0001145_abnormal_male_reproductive0.68160220
80MP0003699_abnormal_female_reproductive0.66319450
81MP0000627_abnormal_mammary_gland0.65810842
82MP0003861_abnormal_nervous_system0.64666792
83MP0003115_abnormal_respiratory_system0.64384256
84MP0000733_abnormal_muscle_development0.63055850
85MP0002166_altered_tumor_susceptibility0.63026753
86MP0002398_abnormal_bone_marrow0.62564113
87MP0010678_abnormal_skin_adnexa0.62312943
88MP0003942_abnormal_urinary_system0.61103555
89MP0003385_abnormal_body_wall0.59956290
90MP0001727_abnormal_embryo_implantation0.59240929
91MP0001216_abnormal_epidermal_layer0.58340763
92MP0001119_abnormal_female_reproductive0.57713326
93MP0002796_impaired_skin_barrier0.57581274
94MP0002075_abnormal_coat/hair_pigmentati0.56190750
95MP0000653_abnormal_sex_gland0.55767661
96MP0002722_abnormal_immune_system0.55069441
97MP0001186_pigmentation_phenotype0.55008558
98MP0001853_heart_inflammation0.54723051
99MP0000858_altered_metastatic_potential0.54397269
100MP0002098_abnormal_vibrissa_morphology0.54056803

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)6.40086543
2Chromsome breakage (HP:0040012)6.06767177
3Increased nuchal translucency (HP:0010880)3.97886022
4Abnormality of chromosome stability (HP:0003220)3.89045733
5Cortical dysplasia (HP:0002539)3.61216514
6Meckel diverticulum (HP:0002245)3.44622544
7Abnormality of the preputium (HP:0100587)3.40495371
8Aplasia/Hypoplasia of the uvula (HP:0010293)3.38239335
9Birth length less than 3rd percentile (HP:0003561)3.31938407
10Nephroblastoma (Wilms tumor) (HP:0002667)3.27083056
11Abnormality of the ileum (HP:0001549)3.23873528
12Embryonal renal neoplasm (HP:0011794)3.04377850
13Duodenal stenosis (HP:0100867)2.97949450
14Small intestinal stenosis (HP:0012848)2.97949450
15Overlapping toe (HP:0001845)2.93432702
16Deep philtrum (HP:0002002)2.90463169
17Myelodysplasia (HP:0002863)2.89605106
18Volvulus (HP:0002580)2.84838018
19Cafe-au-lait spot (HP:0000957)2.83121225
20Abnormality of the carotid arteries (HP:0005344)2.82654294
21Reticulocytopenia (HP:0001896)2.67470199
22Ectopic kidney (HP:0000086)2.53666580
23Selective tooth agenesis (HP:0001592)2.48021903
24Abnormality of the duodenum (HP:0002246)2.42297958
25Abnormality of chromosome segregation (HP:0002916)2.40570723
26Proximal placement of thumb (HP:0009623)2.40300164
27Missing ribs (HP:0000921)2.39294305
28Deviation of the thumb (HP:0009603)2.37295272
29Abnormal lung lobation (HP:0002101)2.37263046
30Abnormality of cochlea (HP:0000375)2.33941567
31Medulloblastoma (HP:0002885)2.33708572
32High anterior hairline (HP:0009890)2.27880202
33Hyperacusis (HP:0010780)2.27556038
34Ankyloglossia (HP:0010296)2.23049732
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.17117417
36Acute myeloid leukemia (HP:0004808)2.16683675
37Rhabdomyosarcoma (HP:0002859)2.15758272
38Sloping forehead (HP:0000340)2.13921887
39Clubbing of toes (HP:0100760)2.13306397
40Progressive external ophthalmoplegia (HP:0000590)2.12846736
41Choanal atresia (HP:0000453)2.12197252
42Abnormal gallbladder physiology (HP:0012438)2.09783728
43Cholecystitis (HP:0001082)2.09783728
44Relative macrocephaly (HP:0004482)2.09394053
45Absent radius (HP:0003974)2.09312217
46Arteriovenous malformation (HP:0100026)2.09049237
47Breast hypoplasia (HP:0003187)2.08743247
48Abnormality of the calcaneus (HP:0008364)2.08506316
49Abnormality of oral frenula (HP:0000190)2.05945903
50Duplication of thumb phalanx (HP:0009942)2.05734522
51Sandal gap (HP:0001852)2.05559066
52Embryonal neoplasm (HP:0002898)2.04524397
53Acute lymphatic leukemia (HP:0006721)2.00458858
54Facial hemangioma (HP:0000329)1.97692932
55Ependymoma (HP:0002888)1.97041725
56Squamous cell carcinoma (HP:0002860)1.97033262
57Leiomyosarcoma (HP:0100243)1.95304499
58Uterine leiomyosarcoma (HP:0002891)1.95304499
59Heterotopia (HP:0002282)1.93828335
60Multiple enchondromatosis (HP:0005701)1.93626539
6111 pairs of ribs (HP:0000878)1.91277764
62Malignant gastrointestinal tract tumors (HP:0006749)1.89244075
63Gastrointestinal carcinoma (HP:0002672)1.89244075
64Triphalangeal thumb (HP:0001199)1.88348529
65High pitched voice (HP:0001620)1.88193510
66Abnormality of the fingertips (HP:0001211)1.87833832
67Aplasia involving forearm bones (HP:0009822)1.86458691
68Absent forearm bone (HP:0003953)1.86458691
69Asymmetry of the thorax (HP:0001555)1.84009555
70Obsessive-compulsive behavior (HP:0000722)1.82794802
71Skull defect (HP:0001362)1.81426068
72Atresia of the external auditory canal (HP:0000413)1.81157588
73Glioma (HP:0009733)1.80639897
74Capillary hemangiomas (HP:0005306)1.80096875
75Duplicated collecting system (HP:0000081)1.78851323
76Insomnia (HP:0100785)1.78421732
77Urethral obstruction (HP:0000796)1.73899837
78Abnormality of DNA repair (HP:0003254)1.71478179
79Flared metaphyses (HP:0003015)1.70667603
80Overriding aorta (HP:0002623)1.70648083
81Broad distal phalanx of finger (HP:0009836)1.70052593
82Abnormal foot bone ossification (HP:0010675)1.68896713
83Progressive muscle weakness (HP:0003323)1.68566904
84Short middle phalanx of the 5th finger (HP:0004220)1.68289879
85Radioulnar synostosis (HP:0002974)1.66923394
86Poikiloderma (HP:0001029)1.66540146
87Transitional cell carcinoma of the bladder (HP:0006740)1.65996056
88Horseshoe kidney (HP:0000085)1.65678852
89Termporal pattern (HP:0011008)1.65644757
90Insidious onset (HP:0003587)1.65644757
91Spinal cord lesions (HP:0100561)1.63812980
92Syringomyelia (HP:0003396)1.63812980
93Short thumb (HP:0009778)1.63049007
94Hypopigmentation of the fundus (HP:0007894)1.62885306
95Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62804698
96Astrocytoma (HP:0009592)1.62649685
97Abnormality of the astrocytes (HP:0100707)1.62649685
98Abnormality of reticulocytes (HP:0004312)1.62204364
99Trigonocephaly (HP:0000243)1.62130956
100Spastic diplegia (HP:0001264)1.61663640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.01824834
2TTK3.77052024
3BUB13.40591711
4WEE13.26387513
5CDK123.00172495
6MAP3K102.64637384
7EEF2K2.58923859
8SRPK12.39926886
9PLK42.28793495
10BRSK22.28201742
11SMG12.25467089
12EIF2AK12.03184477
13NEK12.02633473
14BRD42.02458686
15SCYL21.95857552
16TSSK61.95174123
17CHEK21.88941473
18PBK1.87732116
19ICK1.82819315
20MKNK11.80106466
21EIF2AK31.77745736
22ATR1.68668779
23TRIB31.62699369
24CDK71.59125994
25NEK21.58134492
26PLK31.57592349
27BRSK11.54354395
28PLK11.52090620
29MKNK21.45191154
30IRAK31.44551141
31TAF11.42606564
32PRPF4B1.36773118
33CHEK11.35076383
34RPS6KB21.34520796
35CDK41.33584452
36CDK61.29023200
37CLK11.27353994
38MAP3K81.24539907
39AURKB1.24072523
40LATS21.19363415
41PASK1.13502692
42PNCK1.11747220
43CCNB11.07698050
44ATM1.07435854
45BRAF1.06377779
46KSR21.03934337
47EIF2AK21.00927204
48NME20.98464528
49MELK0.97486097
50MAP3K130.96908103
51STK30.89369583
52CDK80.88455742
53STK40.88354653
54CAMK1G0.86735000
55LATS10.85143764
56PDGFRA0.84441764
57KSR10.81134752
58VRK20.81054858
59CDK10.80328806
60CAMK1D0.79010167
61CDK20.78799943
62NEK90.77864677
63RAF10.74588310
64ZAK0.73497375
65MTOR0.71449589
66STK100.71251810
67MAP3K140.70244941
68ALK0.69251363
69AURKA0.68775425
70PAK40.64601718
71PKN20.62468021
72MAP3K90.61878490
73CDK30.53433087
74STK240.52904944
75YES10.51554009
76CDK90.50818694
77RPS6KA40.50584963
78TAOK20.46144434
79FGFR40.45431492
80MET0.45369382
81ERBB40.45357564
82FLT30.44747348
83FGFR10.44613705
84BMX0.44319409
85CDK180.43682518
86PRKDC0.43244148
87CDK150.43225961
88VRK10.41018715
89CDK11A0.41005543
90MST1R0.40562105
91DYRK30.39089075
92TRIM280.38212131
93SIK30.37905810
94MAPK110.37622237
95PIM10.37367679
96CDK140.33958415
97ARAF0.31686896
98MOS0.30246888
99TTN0.29560803
100MAPK140.28970899

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17563057
2Mismatch repair_Homo sapiens_hsa034304.17669733
3Cell cycle_Homo sapiens_hsa041103.58490457
4Non-homologous end-joining_Homo sapiens_hsa034503.20551420
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.11801662
6Homologous recombination_Homo sapiens_hsa034402.78475670
7Base excision repair_Homo sapiens_hsa034102.65809953
8Fanconi anemia pathway_Homo sapiens_hsa034602.57650752
9Nucleotide excision repair_Homo sapiens_hsa034202.53502635
10RNA transport_Homo sapiens_hsa030132.45920095
11One carbon pool by folate_Homo sapiens_hsa006702.45198771
12Spliceosome_Homo sapiens_hsa030402.37390633
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20773780
14mRNA surveillance pathway_Homo sapiens_hsa030151.94055036
15Chronic myeloid leukemia_Homo sapiens_hsa052201.65109129
16MicroRNAs in cancer_Homo sapiens_hsa052061.46811547
17Thyroid cancer_Homo sapiens_hsa052161.46189092
18p53 signaling pathway_Homo sapiens_hsa041151.45405210
19Biosynthesis of amino acids_Homo sapiens_hsa012301.33928767
20Bladder cancer_Homo sapiens_hsa052191.27777536
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24441046
22Pancreatic cancer_Homo sapiens_hsa052121.23886608
23Pyrimidine metabolism_Homo sapiens_hsa002401.23758052
24Non-small cell lung cancer_Homo sapiens_hsa052231.21841149
25RNA degradation_Homo sapiens_hsa030181.17522616
26Prostate cancer_Homo sapiens_hsa052151.17146740
27Oocyte meiosis_Homo sapiens_hsa041141.16121548
28Small cell lung cancer_Homo sapiens_hsa052221.15986778
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.15441289
30Viral carcinogenesis_Homo sapiens_hsa052031.15365940
31Lysine degradation_Homo sapiens_hsa003101.12771362
32Basal transcription factors_Homo sapiens_hsa030221.11123169
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.08920898
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07147594
35Hepatitis B_Homo sapiens_hsa051611.04483714
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02379197
37Vitamin B6 metabolism_Homo sapiens_hsa007500.95030459
38HTLV-I infection_Homo sapiens_hsa051660.94112923
39Colorectal cancer_Homo sapiens_hsa052100.93669611
40Adherens junction_Homo sapiens_hsa045200.93343066
41Selenocompound metabolism_Homo sapiens_hsa004500.88676045
42Acute myeloid leukemia_Homo sapiens_hsa052210.88620585
43Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87923701
44Epstein-Barr virus infection_Homo sapiens_hsa051690.87615489
45Cysteine and methionine metabolism_Homo sapiens_hsa002700.87357251
46Pentose phosphate pathway_Homo sapiens_hsa000300.85886395
47Herpes simplex infection_Homo sapiens_hsa051680.83061429
48Carbon metabolism_Homo sapiens_hsa012000.79920257
49Steroid biosynthesis_Homo sapiens_hsa001000.78912729
50Endometrial cancer_Homo sapiens_hsa052130.78435556
51N-Glycan biosynthesis_Homo sapiens_hsa005100.76797785
52Glioma_Homo sapiens_hsa052140.73573240
53Apoptosis_Homo sapiens_hsa042100.71210392
54Renal cell carcinoma_Homo sapiens_hsa052110.70200024
55Measles_Homo sapiens_hsa051620.69665639
56Ribosome_Homo sapiens_hsa030100.67485236
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64876927
58Proteasome_Homo sapiens_hsa030500.64161792
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63193497
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61400878
61RNA polymerase_Homo sapiens_hsa030200.60281321
62Melanoma_Homo sapiens_hsa052180.58703209
63Proteoglycans in cancer_Homo sapiens_hsa052050.58634103
64Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57703509
65Notch signaling pathway_Homo sapiens_hsa043300.56894514
66Purine metabolism_Homo sapiens_hsa002300.56541409
67Pyruvate metabolism_Homo sapiens_hsa006200.55152538
68Influenza A_Homo sapiens_hsa051640.54534507
69mTOR signaling pathway_Homo sapiens_hsa041500.52624787
70TGF-beta signaling pathway_Homo sapiens_hsa043500.50244841
71ErbB signaling pathway_Homo sapiens_hsa040120.50170346
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48835051
73Basal cell carcinoma_Homo sapiens_hsa052170.48770506
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.48369573
75B cell receptor signaling pathway_Homo sapiens_hsa046620.47639036
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46824197
77Hippo signaling pathway_Homo sapiens_hsa043900.44630008
78Pathways in cancer_Homo sapiens_hsa052000.43345531
79Inositol phosphate metabolism_Homo sapiens_hsa005620.41776284
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41569552
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41042906
82Shigellosis_Homo sapiens_hsa051310.40862939
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40059515
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39941723
85FoxO signaling pathway_Homo sapiens_hsa040680.39601638
86Prion diseases_Homo sapiens_hsa050200.39236709
87HIF-1 signaling pathway_Homo sapiens_hsa040660.38537007
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37017419
89Systemic lupus erythematosus_Homo sapiens_hsa053220.36982854
90Folate biosynthesis_Homo sapiens_hsa007900.35704846
91Wnt signaling pathway_Homo sapiens_hsa043100.35098011
92Prolactin signaling pathway_Homo sapiens_hsa049170.34263457
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.32884589
94Insulin signaling pathway_Homo sapiens_hsa049100.32876208
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.30764297
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30709577
97Hepatitis C_Homo sapiens_hsa051600.30120470
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30100553
99Alcoholism_Homo sapiens_hsa050340.28794272
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.27666558

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