NEMP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.25308132
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.48675294
3nuclear pore complex assembly (GO:0051292)4.40397049
4positive regulation of granulocyte differentiation (GO:0030854)4.32287253
5positive thymic T cell selection (GO:0045059)4.31536705
6positive T cell selection (GO:0043368)4.30369087
7regulation of B cell receptor signaling pathway (GO:0050855)4.19505372
8negative thymic T cell selection (GO:0045060)4.01145872
9piRNA metabolic process (GO:0034587)4.00931672
10negative T cell selection (GO:0043383)3.99071966
11definitive hemopoiesis (GO:0060216)3.81066527
12regulation of gamma-delta T cell differentiation (GO:0045586)3.73374055
13histone H3-K36 demethylation (GO:0070544)3.66513352
14B cell receptor signaling pathway (GO:0050853)3.63450056
15nuclear pore organization (GO:0006999)3.56540726
16positive regulation of B cell differentiation (GO:0045579)3.55000352
17mitotic sister chromatid cohesion (GO:0007064)3.53135609
18regulation of gamma-delta T cell activation (GO:0046643)3.45535047
19response to interleukin-15 (GO:0070672)3.45276247
20pore complex assembly (GO:0046931)3.43346556
21T cell selection (GO:0045058)3.38697647
22megakaryocyte development (GO:0035855)3.35270298
23thymic T cell selection (GO:0045061)3.34986347
24positive regulation of alpha-beta T cell proliferation (GO:0046641)3.23138226
25regulation of RIG-I signaling pathway (GO:0039535)3.20206236
26negative regulation of T cell mediated immunity (GO:0002710)3.19179452
27hepatocyte apoptotic process (GO:0097284)3.17726933
28dosage compensation (GO:0007549)3.17696311
29cellular response to interleukin-15 (GO:0071350)3.10383467
30regulation of B cell differentiation (GO:0045577)3.06443690
31meiotic chromosome segregation (GO:0045132)3.03394477
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.02523117
33regulation of granulocyte differentiation (GO:0030852)3.00670448
34phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.00598161
35T cell migration (GO:0072678)2.96915538
36interkinetic nuclear migration (GO:0022027)2.95873667
37negative regulation of cell killing (GO:0031342)2.95253399
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95253399
39regulation of alpha-beta T cell proliferation (GO:0046640)2.94537068
40positive regulation of interferon-alpha production (GO:0032727)2.94358412
41negative regulation of DNA repair (GO:0045738)2.94055974
42response to muramyl dipeptide (GO:0032495)2.94007946
43tolerance induction (GO:0002507)2.90182435
44sister chromatid cohesion (GO:0007062)2.87207908
45antigen processing and presentation of endogenous antigen (GO:0019883)2.84840174
46alpha-beta T cell activation (GO:0046631)2.82604251
47synapsis (GO:0007129)2.81515695
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.81503559
49DNA synthesis involved in DNA repair (GO:0000731)2.80944288
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80561025
51regulation of histone H3-K9 methylation (GO:0051570)2.80241569
52T cell homeostasis (GO:0043029)2.79723191
53antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.76964477
54alpha-beta T cell differentiation (GO:0046632)2.76160459
55V(D)J recombination (GO:0033151)2.75788105
56regulation of interferon-alpha production (GO:0032647)2.73139767
57embryonic process involved in female pregnancy (GO:0060136)2.72754216
58negative regulation of type I interferon production (GO:0032480)2.70941938
59cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.69457811
60Arp2/3 complex-mediated actin nucleation (GO:0034314)2.68997450
61gene silencing by RNA (GO:0031047)2.68300287
62DNA methylation involved in gamete generation (GO:0043046)2.65872693
63antigen receptor-mediated signaling pathway (GO:0050851)2.60357781
64cellular response to exogenous dsRNA (GO:0071360)2.58688377
65positive regulation of isotype switching (GO:0045830)2.58139769
66natural killer cell differentiation (GO:0001779)2.57985652
67B cell proliferation (GO:0042100)2.57186558
68hypotonic response (GO:0006971)2.53506032
69granulocyte differentiation (GO:0030851)2.52793263
70regulation of necroptotic process (GO:0060544)2.52270392
71DNA unwinding involved in DNA replication (GO:0006268)2.51609963
72translesion synthesis (GO:0019985)2.51575001
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.51325050
74regulation of isotype switching to IgG isotypes (GO:0048302)2.51040574
75mitotic chromosome condensation (GO:0007076)2.50729674
76pinocytosis (GO:0006907)2.50418887
77regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.50115142
78negative regulation of defense response to virus (GO:0050687)2.50023113
79histone H3-K9 demethylation (GO:0033169)2.48989044
80negative regulation of erythrocyte differentiation (GO:0045647)2.48813341
81B cell homeostasis (GO:0001782)2.47843171
82CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.47538236
83NIK/NF-kappaB signaling (GO:0038061)2.44609760
84positive regulation of interferon-beta production (GO:0032728)2.43995999
85nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.43149392
86poly(A)+ mRNA export from nucleus (GO:0016973)2.42269876
87cytoplasmic mRNA processing body assembly (GO:0033962)2.41473368
88positive regulation of alpha-beta T cell activation (GO:0046635)2.40617782
89CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.39960282
90T-helper cell differentiation (GO:0042093)2.39960282
91regulation of fibroblast apoptotic process (GO:2000269)2.38966483
92Peyers patch development (GO:0048541)2.38694922
93mucosal-associated lymphoid tissue development (GO:0048537)2.38694922
94regulation of interferon-beta biosynthetic process (GO:0045357)2.38347140
95interferon-gamma production (GO:0032609)2.37776847
96T cell receptor signaling pathway (GO:0050852)2.37074079
97CD4-positive, alpha-beta T cell activation (GO:0035710)2.36917664
98regulation of regulatory T cell differentiation (GO:0045589)2.36435635
99negative regulation of T-helper cell differentiation (GO:0045623)2.35831448
100negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.35831448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.03550831
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87878888
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.23610578
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.00035756
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.04873707
6MYC_22102868_ChIP-Seq_BL_Human2.76685304
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74188953
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.72839515
9MYB_26560356_Chip-Seq_TH2_Human2.69287299
10RUNX_20019798_ChIP-Seq_JUKART_Human2.68616413
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68485415
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.64733977
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.50363420
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46079285
15ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.31215917
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.28811334
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.27083510
18MYB_26560356_Chip-Seq_TH1_Human2.24282226
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17838413
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.13316365
21SCL_19346495_ChIP-Seq_HPC-7_Human2.11817813
22IRF8_21731497_ChIP-ChIP_J774_Mouse2.10288955
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.09426803
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.08120763
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03367178
26SPI1_23547873_ChIP-Seq_NB4_Human2.02733989
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.98552700
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.97358666
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.93942806
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.90729478
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.84951860
32CIITA_25753668_ChIP-Seq_RAJI_Human1.83785304
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82980516
34MAF_26560356_Chip-Seq_TH1_Human1.82162819
35VDR_21846776_ChIP-Seq_THP-1_Human1.76075869
36GATA3_27048872_Chip-Seq_THYMUS_Human1.74857216
37VDR_24763502_ChIP-Seq_THP-1_Human1.65402976
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.65365968
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.64671287
40UTX_26944678_Chip-Seq_JUKART_Human1.63637548
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.56861940
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55431248
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.52818461
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.52127850
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.49763727
46GATA3_26560356_Chip-Seq_TH2_Human1.43507683
47ERG_20887958_ChIP-Seq_HPC-7_Mouse1.43291861
48SPI1_23127762_ChIP-Seq_K562_Human1.42268623
49FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40219058
50KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39261043
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38477421
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36866617
53TCF7_22412390_ChIP-Seq_EML_Mouse1.36270973
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35390097
55VDR_23849224_ChIP-Seq_CD4+_Human1.35238102
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34669018
57RUNX1_22412390_ChIP-Seq_EML_Mouse1.34141268
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34019415
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30526681
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29270506
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29025494
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.27242895
63KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26222625
64GATA1_22025678_ChIP-Seq_K562_Human1.26010259
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24798206
66ELK1_19687146_ChIP-ChIP_HELA_Human1.24062504
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23997038
68TFEB_21752829_ChIP-Seq_HELA_Human1.23159422
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21337063
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19698738
71PU_27001747_Chip-Seq_BMDM_Mouse1.19417148
72MAF_26560356_Chip-Seq_TH2_Human1.19218838
73FOXP3_21729870_ChIP-Seq_TREG_Human1.15977710
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.15509399
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13567029
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.09937801
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09135967
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03246297
79RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02087093
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01942649
81VDR_24787735_ChIP-Seq_THP-1_Human0.96667926
82MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96192242
83YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92294167
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92009791
85GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89894325
86DCP1A_22483619_ChIP-Seq_HELA_Human0.89354729
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88268838
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88138294
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87266202
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86952777
91KDM5A_27292631_Chip-Seq_BREAST_Human0.86399633
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85979329
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85537731
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.85066731
95PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84830084
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84360368
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.84234334
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.83320836
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.82441840
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.82359258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.93419074
2MP0003763_abnormal_thymus_physiology3.83901654
3MP0003303_peritoneal_inflammation2.98665369
4MP0002396_abnormal_hematopoietic_system2.98625848
5MP0001835_abnormal_antigen_presentation2.92559796
6MP0000569_abnormal_digit_pigmentation2.81287614
7MP0002166_altered_tumor_susceptibility2.45234018
8MP0001800_abnormal_humoral_immune2.28318247
9MP0002009_preneoplasia2.18843736
10MP0010094_abnormal_chromosome_stability2.16759955
11MP0002398_abnormal_bone_marrow2.13588403
12MP0004808_abnormal_hematopoietic_stem2.11777407
13MP0005464_abnormal_platelet_physiology2.08776068
14MP0000685_abnormal_immune_system2.08444237
15MP0000703_abnormal_thymus_morphology2.08056225
16MP0002877_abnormal_melanocyte_morpholog1.91787625
17MP0005000_abnormal_immune_tolerance1.89758873
18MP0002723_abnormal_immune_serum1.89236445
19MP0002420_abnormal_adaptive_immunity1.87966370
20MP0002006_tumorigenesis1.86601654
21MP0004381_abnormal_hair_follicle1.86080320
22MP0005671_abnormal_response_to1.85522924
23MP0003436_decreased_susceptibility_to1.85154168
24MP0001819_abnormal_immune_cell1.84673916
25MP0008877_abnormal_DNA_methylation1.83857861
26MP0002722_abnormal_immune_system1.79497298
27MP0003111_abnormal_nucleus_morphology1.79414362
28MP0002452_abnormal_antigen_presenting1.79368832
29MP0001790_abnormal_immune_system1.78614788
30MP0005387_immune_system_phenotype1.78614788
31MP0009333_abnormal_splenocyte_physiolog1.76694763
32MP0003172_abnormal_lysosome_physiology1.75032398
33MP0000689_abnormal_spleen_morphology1.74111898
34MP0000716_abnormal_immune_system1.72261213
35MP0004947_skin_inflammation1.68543898
36MP0000015_abnormal_ear_pigmentation1.62626219
37MP0002405_respiratory_system_inflammati1.62353968
38MP0003724_increased_susceptibility_to1.60564154
39MP0005075_abnormal_melanosome_morpholog1.59719478
40MP0001853_heart_inflammation1.57538230
41MP0002138_abnormal_hepatobiliary_system1.56269297
42MP0002419_abnormal_innate_immunity1.53897627
43MP0003300_gastrointestinal_ulcer1.53126272
44MP0002429_abnormal_blood_cell1.51802589
45MP0008058_abnormal_DNA_repair1.51559190
46MP0005025_abnormal_response_to1.50063667
47MP0008007_abnormal_cellular_replicative1.46697531
48MP0000465_gastrointestinal_hemorrhage1.46067831
49MP0001873_stomach_inflammation1.39424087
50MP0003656_abnormal_erythrocyte_physiolo1.38976378
51MP0010307_abnormal_tumor_latency1.37964097
52MP0003191_abnormal_cellular_cholesterol1.34051841
53MP0003077_abnormal_cell_cycle1.33158200
54MP0003866_abnormal_defecation1.30968174
55MP0002148_abnormal_hypersensitivity_rea1.30421666
56MP0010155_abnormal_intestine_physiology1.30098877
57MP0008260_abnormal_autophagy1.29199582
58MP0009278_abnormal_bone_marrow1.27153083
59MP0001851_eye_inflammation1.26852505
60MP0005174_abnormal_tail_pigmentation1.24584882
61MP0009785_altered_susceptibility_to1.24523099
62MP0005310_abnormal_salivary_gland1.21666553
63MP0003183_abnormal_peptide_metabolism1.21561268
64MP0003786_premature_aging1.21560080
65MP0002019_abnormal_tumor_incidence1.21361593
66MP0005451_abnormal_body_composition1.20591827
67MP0003828_pulmonary_edema1.18651985
68MP0003693_abnormal_embryo_hatching1.18625746
69MP0006082_CNS_inflammation1.17332342
70MP0003950_abnormal_plasma_membrane1.13794696
71MP0005397_hematopoietic_system_phenotyp1.12411480
72MP0001545_abnormal_hematopoietic_system1.12411480
73MP0000372_irregular_coat_pigmentation1.10183259
74MP0005076_abnormal_cell_differentiation1.09297350
75MP0000858_altered_metastatic_potential1.08978484
76MP0004957_abnormal_blastocyst_morpholog1.07286417
77MP0001845_abnormal_inflammatory_respons1.04799338
78MP0009697_abnormal_copulation0.95720109
79MP0005058_abnormal_lysosome_morphology0.95630599
80MP0000490_abnormal_crypts_of0.91842707
81MP0005621_abnormal_cell_physiology0.85419907
82MP0005409_darkened_coat_color0.83552512
83MP0000313_abnormal_cell_death0.83188374
84MP0001915_intracranial_hemorrhage0.82635795
85MP0005220_abnormal_exocrine_pancreas0.81690297
86MP0003943_abnormal_hepatobiliary_system0.81239062
87MP0000350_abnormal_cell_proliferation0.80990797
88MP0008469_abnormal_protein_level0.78625836
89MP0009115_abnormal_fat_cell0.76825119
90MP0003252_abnormal_bile_duct0.75497013
91MP0004185_abnormal_adipocyte_glucose0.75094895
92MP0002998_abnormal_bone_remodeling0.74841139
93MP0000358_abnormal_cell_content/0.71873016
94MP0001533_abnormal_skeleton_physiology0.71813339
95MP0003091_abnormal_cell_migration0.71373527
96MP0002933_joint_inflammation0.71012740
97MP0005384_cellular_phenotype0.70724364
98MP0010352_gastrointestinal_tract_polyps0.70413302
99MP0008004_abnormal_stomach_pH0.68041595
100MP0003221_abnormal_cardiomyocyte_apopto0.67569812

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.59524581
2Abnormality of T cell number (HP:0011839)4.91654207
3Recurrent viral infections (HP:0004429)4.38585205
4Panhypogammaglobulinemia (HP:0003139)4.03700479
5Abnormality of T cells (HP:0002843)3.84382337
6Severe combined immunodeficiency (HP:0004430)3.78700867
7Autoimmune hemolytic anemia (HP:0001890)3.65121923
8Recurrent fungal infections (HP:0002841)3.61445780
9Combined immunodeficiency (HP:0005387)3.60473971
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.49032585
11B lymphocytopenia (HP:0010976)3.39725292
12Abnormality of B cell number (HP:0010975)3.31278923
13Recurrent cutaneous fungal infections (HP:0011370)3.29508824
14Chronic mucocutaneous candidiasis (HP:0002728)3.29508824
15Inflammation of the large intestine (HP:0002037)3.11606168
16IgM deficiency (HP:0002850)3.10159167
17Agammaglobulinemia (HP:0004432)3.08230677
18Gastrointestinal inflammation (HP:0004386)3.01998807
19Acute lymphatic leukemia (HP:0006721)3.01806000
20IgA deficiency (HP:0002720)3.01003775
21Colitis (HP:0002583)3.00379279
22Volvulus (HP:0002580)2.99535639
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93889296
24Hypoplasia of the thymus (HP:0000778)2.92816528
25Granulocytopenia (HP:0001913)2.92649809
26Chronic diarrhea (HP:0002028)2.90883342
27Abnormality of T cell physiology (HP:0011840)2.89280692
28Meningitis (HP:0001287)2.85871087
29Thyroiditis (HP:0100646)2.80149107
30Acute myeloid leukemia (HP:0004808)2.79261277
31Menstrual irregularities (HP:0000858)2.74039998
32Encephalitis (HP:0002383)2.65957995
33Mediastinal lymphadenopathy (HP:0100721)2.61133140
34Recurrent bacterial skin infections (HP:0005406)2.61121221
35Chromsome breakage (HP:0040012)2.58890665
36Recurrent abscess formation (HP:0002722)2.56300766
37Fatigue (HP:0012378)2.53082124
38Viral hepatitis (HP:0006562)2.52507710
39Aplasia/Hypoplasia of the thymus (HP:0010515)2.51148653
40IgG deficiency (HP:0004315)2.51109724
4111 pairs of ribs (HP:0000878)2.42121448
42Recurrent skin infections (HP:0001581)2.41898808
43Eosinophilia (HP:0001880)2.41822532
44Eczematoid dermatitis (HP:0000976)2.37247852
45Elevated erythrocyte sedimentation rate (HP:0003565)2.34751305
46Vasculitis (HP:0002633)2.34099242
47Lymphoma (HP:0002665)2.31103919
48Abnormality of the fingertips (HP:0001211)2.30265618
49Abnormality of the prostate (HP:0008775)2.30078583
50Prolonged bleeding time (HP:0003010)2.29499959
51Abnormality of eosinophils (HP:0001879)2.25128670
52Slow saccadic eye movements (HP:0000514)2.24847189
53Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24634593
54Lower limb hyperreflexia (HP:0002395)2.24103020
55Abnormality of chromosome stability (HP:0003220)2.23567153
56Thrombocytosis (HP:0001894)2.15417798
57Autoamputation (HP:0001218)2.15227608
58Epistaxis (HP:0000421)2.14300758
59Osteomyelitis (HP:0002754)2.14256706
60Gastrointestinal infarctions (HP:0005244)2.13052027
61Lymphopenia (HP:0001888)2.11494980
62Autoimmune thrombocytopenia (HP:0001973)2.11249686
63Prominent nose (HP:0000448)2.10953371
64Abnormality of the thymus (HP:0000777)2.10346441
65Pustule (HP:0200039)2.08248516
66Basal cell carcinoma (HP:0002671)2.07733750
67Chronic obstructive pulmonary disease (HP:0006510)2.05153117
68Obstructive lung disease (HP:0006536)2.05153117
69Leukocytosis (HP:0001974)2.02785830
70Cutis marmorata (HP:0000965)2.02474038
71Fair hair (HP:0002286)2.02195035
72Recurrent bronchitis (HP:0002837)2.00594432
73Abnormality of cells of the lymphoid lineage (HP:0012140)1.99640883
74Myositis (HP:0100614)1.98682911
75Myelodysplasia (HP:0002863)1.98501125
76Dislocated radial head (HP:0003083)1.98011274
77Keratoconjunctivitis sicca (HP:0001097)1.94905903
78Cellulitis (HP:0100658)1.94468949
79Acute hepatic failure (HP:0006554)1.94326656
80Stomatitis (HP:0010280)1.91705048
81Abnormality of DNA repair (HP:0003254)1.90970903
82Conjunctival telangiectasia (HP:0000524)1.87126768
83Abnormality of macrophages (HP:0004311)1.84874906
84Anhidrosis (HP:0000970)1.84013847
85Periodontitis (HP:0000704)1.83536115
86Abnormal spermatogenesis (HP:0008669)1.83468167
87Spontaneous hematomas (HP:0007420)1.83362619
88Keratoconjunctivitis (HP:0001096)1.83208808
89Optic neuritis (HP:0100653)1.82356875
90Retrobulbar optic neuritis (HP:0100654)1.82356875
91Gingival bleeding (HP:0000225)1.81177890
92Increased neuronal autofluorescent lipopigment (HP:0002074)1.79008460
93Deep palmar crease (HP:0006191)1.77282830
94Glucose intolerance (HP:0000833)1.76524366
95Tubulointerstitial nephritis (HP:0001970)1.76179946
96Chest pain (HP:0100749)1.76082346
97Prostate neoplasm (HP:0100787)1.75926948
98Abnormality of the columella (HP:0009929)1.74678202
99Dyschromatopsia (HP:0007641)1.73705548
100Sandal gap (HP:0001852)1.73177837

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.19374835
2MAP3K143.06199768
3TXK3.02355747
4SCYL22.63428830
5PRPF4B2.37742195
6RIPK42.11073473
7FES2.02267312
8CDK122.01428225
9BRD41.86585260
10CSF1R1.85728445
11RPS6KA41.82989893
12MAP4K21.82513226
13MAP3K131.79575923
14IKBKE1.69239650
15KIT1.67240397
16MAP2K31.65290001
17BTK1.64479871
18BMPR21.55556702
19CDC71.52636525
20TEC1.51923280
21FLT31.51633988
22MAPK111.51055296
23SYK1.49701476
24ITK1.40891983
25IRAK41.39445295
26FGFR31.39271835
27JAK31.38617054
28CDK61.38127224
29CDK41.35488905
30TAOK31.35181165
31JAK11.33333061
32TYK21.32998712
33ZAP701.31350332
34LCK1.27296126
35NLK1.27165359
36BLK1.25001695
37MARK31.22378415
38MELK1.20390618
39PIK3CG1.15075674
40CLK11.14950604
41CSK1.14896578
42TBK11.14794945
43NEK91.12280225
44STK241.07067176
45PLK41.05356748
46MUSK1.02985384
47PASK1.00342085
48CDK81.00303979
49STK100.97711313
50MAP3K100.96140320
51IKBKB0.93632268
52HCK0.92744813
53EIF2AK30.91806447
54TRPM70.90582821
55GRK60.90575946
56LYN0.86562241
57STK40.85272115
58RPS6KB20.84579042
59IRAK30.82502958
60TAF10.82351954
61ATR0.82232951
62CAMKK20.81483340
63SIK30.77837695
64CDK30.77027613
65PIM10.72983731
66CHEK10.71500572
67FGR0.71128757
68MAP3K110.67912045
69CDK90.66111590
70PDGFRB0.65820906
71YES10.65363453
72IRAK20.62706068
73NME20.60205387
74FRK0.58826651
75STK30.58594721
76CDK190.57372015
77CDK70.57154665
78AKT30.57136321
79MATK0.56704225
80EEF2K0.55924350
81NUAK10.55358207
82ICK0.54990993
83SGK30.54862258
84EGFR0.53757748
85TGFBR10.52883654
86CAMK1G0.51194705
87ERN10.50168361
88WNK10.49605326
89PDK10.49528153
90ATM0.48584849
91SGK20.47862045
92RPS6KB10.47855162
93MAP2K20.44756397
94SIK20.43900477
95PRKD20.41454195
96CHUK0.41433468
97NEK20.39541238
98HIPK20.38560540
99TTK0.38499938
100MAPKAPK30.37817794

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.86123969
2DNA replication_Homo sapiens_hsa030302.23759256
3B cell receptor signaling pathway_Homo sapiens_hsa046622.11918253
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.10864919
5Allograft rejection_Homo sapiens_hsa053302.02880736
6Measles_Homo sapiens_hsa051622.01404683
7T cell receptor signaling pathway_Homo sapiens_hsa046602.00603111
8Graft-versus-host disease_Homo sapiens_hsa053321.98632045
9Leishmaniasis_Homo sapiens_hsa051401.96415830
10Autoimmune thyroid disease_Homo sapiens_hsa053201.93788213
11Non-small cell lung cancer_Homo sapiens_hsa052231.85622222
12NF-kappa B signaling pathway_Homo sapiens_hsa040641.83550278
13Acute myeloid leukemia_Homo sapiens_hsa052211.72665755
14Herpes simplex infection_Homo sapiens_hsa051681.69555974
15Chronic myeloid leukemia_Homo sapiens_hsa052201.62512797
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61104192
17Asthma_Homo sapiens_hsa053101.60502916
18Hematopoietic cell lineage_Homo sapiens_hsa046401.60234545
19Antigen processing and presentation_Homo sapiens_hsa046121.56112824
20Osteoclast differentiation_Homo sapiens_hsa043801.53414329
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.53071254
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.52262256
23Hepatitis B_Homo sapiens_hsa051611.51735343
24Cell cycle_Homo sapiens_hsa041101.51068741
25Pancreatic cancer_Homo sapiens_hsa052121.50082991
26Viral carcinogenesis_Homo sapiens_hsa052031.44324180
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43884920
28Influenza A_Homo sapiens_hsa051641.42628352
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42483272
30Mismatch repair_Homo sapiens_hsa034301.41594689
31Toxoplasmosis_Homo sapiens_hsa051451.33235958
32Non-homologous end-joining_Homo sapiens_hsa034501.31833966
33Nucleotide excision repair_Homo sapiens_hsa034201.30522536
34Viral myocarditis_Homo sapiens_hsa054161.29495817
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.29148910
36Type I diabetes mellitus_Homo sapiens_hsa049401.28400498
37Platelet activation_Homo sapiens_hsa046111.27919260
38Fanconi anemia pathway_Homo sapiens_hsa034601.27438737
39Base excision repair_Homo sapiens_hsa034101.26709560
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24521620
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24347300
42Small cell lung cancer_Homo sapiens_hsa052221.23006798
43Systemic lupus erythematosus_Homo sapiens_hsa053221.20867868
44HTLV-I infection_Homo sapiens_hsa051661.18734888
45Thyroid cancer_Homo sapiens_hsa052161.18159643
46Epstein-Barr virus infection_Homo sapiens_hsa051691.17791840
47TNF signaling pathway_Homo sapiens_hsa046681.11704310
48Apoptosis_Homo sapiens_hsa042101.09225686
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08129385
50Tuberculosis_Homo sapiens_hsa051521.07735620
51Prolactin signaling pathway_Homo sapiens_hsa049171.07361719
52p53 signaling pathway_Homo sapiens_hsa041151.05228475
53Colorectal cancer_Homo sapiens_hsa052101.05086829
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04476072
55Shigellosis_Homo sapiens_hsa051311.03843741
56Dorso-ventral axis formation_Homo sapiens_hsa043201.02372713
57Prostate cancer_Homo sapiens_hsa052150.97985322
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97600707
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93915088
60Staphylococcus aureus infection_Homo sapiens_hsa051500.92280787
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89889771
62Homologous recombination_Homo sapiens_hsa034400.87554525
63Hepatitis C_Homo sapiens_hsa051600.86683530
64RNA transport_Homo sapiens_hsa030130.85930763
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.85390852
66Endometrial cancer_Homo sapiens_hsa052130.82399589
67Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80083401
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79935334
69Renal cell carcinoma_Homo sapiens_hsa052110.79278808
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.78816416
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.76949279
72Chemokine signaling pathway_Homo sapiens_hsa040620.75496212
73One carbon pool by folate_Homo sapiens_hsa006700.74257001
74VEGF signaling pathway_Homo sapiens_hsa043700.72111924
75Spliceosome_Homo sapiens_hsa030400.70885830
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.70876331
77FoxO signaling pathway_Homo sapiens_hsa040680.70750968
78mTOR signaling pathway_Homo sapiens_hsa041500.70725178
79Legionellosis_Homo sapiens_hsa051340.70598931
80mRNA surveillance pathway_Homo sapiens_hsa030150.70428148
81MicroRNAs in cancer_Homo sapiens_hsa052060.68164813
82Inositol phosphate metabolism_Homo sapiens_hsa005620.67624054
83RNA degradation_Homo sapiens_hsa030180.64563298
84Basal transcription factors_Homo sapiens_hsa030220.62036132
85Other glycan degradation_Homo sapiens_hsa005110.60825278
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59525223
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.57304519
88ErbB signaling pathway_Homo sapiens_hsa040120.54870645
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52058813
90Glioma_Homo sapiens_hsa052140.52045672
91Malaria_Homo sapiens_hsa051440.51373312
92Lysine degradation_Homo sapiens_hsa003100.51296844
93Rheumatoid arthritis_Homo sapiens_hsa053230.48991008
94Pyrimidine metabolism_Homo sapiens_hsa002400.48744817
95Selenocompound metabolism_Homo sapiens_hsa004500.48096248
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46927520
97N-Glycan biosynthesis_Homo sapiens_hsa005100.46006349
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43755179
99Proteoglycans in cancer_Homo sapiens_hsa052050.42757286
100Choline metabolism in cancer_Homo sapiens_hsa052310.40338674

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