NEPNP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein refolding (GO:0042026)8.08840749
2chaperone mediated protein folding requiring cofactor (GO:0051085)7.02744065
3negative regulation of inclusion body assembly (GO:0090084)6.22128226
4cullin deneddylation (GO:0010388)5.81412187
5protein deneddylation (GO:0000338)5.34309962
6nuclear pore organization (GO:0006999)4.89282399
7maturation of 5.8S rRNA (GO:0000460)4.77321894
8DNA damage response, detection of DNA damage (GO:0042769)4.67806153
9ribosome assembly (GO:0042255)4.48781655
10succinate metabolic process (GO:0006105)4.43924619
11nuclear pore complex assembly (GO:0051292)4.36970461
12GMP metabolic process (GO:0046037)4.35560338
13RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.24763176
14tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.24763176
15regulation of translational termination (GO:0006449)4.17692927
16purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.92313368
17oxaloacetate metabolic process (GO:0006107)3.90506775
18zinc ion transmembrane transport (GO:0071577)3.87471778
19DNA strand elongation involved in DNA replication (GO:0006271)3.84442024
20DNA strand elongation (GO:0022616)3.84241459
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.84145912
22ubiquinone biosynthetic process (GO:0006744)3.82599640
23proteasome assembly (GO:0043248)3.79217295
24deoxyribonucleotide biosynthetic process (GO:0009263)3.77880641
25deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.74379699
26formation of translation preinitiation complex (GO:0001731)3.66565541
27valine metabolic process (GO:0006573)3.59900865
28ubiquinone metabolic process (GO:0006743)3.56032741
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.55832749
30de novo protein folding (GO:0006458)3.55527194
31regulation of inclusion body assembly (GO:0090083)3.52523864
322-deoxyribonucleotide biosynthetic process (GO:0009265)3.52132351
33deoxyribose phosphate biosynthetic process (GO:0046385)3.52132351
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50542921
35chromatin remodeling at centromere (GO:0031055)3.48844125
36de novo posttranslational protein folding (GO:0051084)3.47102960
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45993971
38DNA replication initiation (GO:0006270)3.45160186
39negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43282353
40negative regulation of ligase activity (GO:0051352)3.43282353
41regulation of coenzyme metabolic process (GO:0051196)3.42772412
42regulation of cofactor metabolic process (GO:0051193)3.42772412
43DNA topological change (GO:0006265)3.41170828
44pore complex assembly (GO:0046931)3.40327001
45CENP-A containing nucleosome assembly (GO:0034080)3.39112116
46telomere maintenance via semi-conservative replication (GO:0032201)3.33062732
47double-strand break repair via nonhomologous end joining (GO:0006303)3.30223937
48non-recombinational repair (GO:0000726)3.30223937
49DNA replication checkpoint (GO:0000076)3.29120057
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.25535919
51branched-chain amino acid metabolic process (GO:0009081)3.23983992
52NADH dehydrogenase complex assembly (GO:0010257)3.22631038
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.22631038
54mitochondrial respiratory chain complex I assembly (GO:0032981)3.22631038
55tRNA aminoacylation for protein translation (GO:0006418)3.19893684
56protein K11-linked ubiquitination (GO:0070979)3.18192857
57amino acid activation (GO:0043038)3.13161496
58tRNA aminoacylation (GO:0043039)3.13161496
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11322330
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11322330
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11322330
62regulation of mitotic spindle checkpoint (GO:1903504)3.10561857
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10561857
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09033212
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09033212
66ribosome biogenesis (GO:0042254)3.08522987
67genitalia morphogenesis (GO:0035112)3.08485895
68mitotic spindle checkpoint (GO:0071174)3.08203186
69quinone biosynthetic process (GO:1901663)3.07426089
70regulation of mitochondrial translation (GO:0070129)3.07101260
71mitotic nuclear envelope disassembly (GO:0007077)3.05114159
72telomere maintenance via recombination (GO:0000722)3.03402078
73signal transduction involved in cell cycle checkpoint (GO:0072395)3.02478763
74signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01709885
75signal transduction involved in DNA damage checkpoint (GO:0072422)3.01709885
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.99745180
77regulation of cellular amino acid metabolic process (GO:0006521)2.97581956
78DNA unwinding involved in DNA replication (GO:0006268)2.97342565
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.96021905
80nucleobase-containing small molecule interconversion (GO:0015949)2.94953638
81AMP metabolic process (GO:0046033)2.94931137
82spindle checkpoint (GO:0031577)2.94877494
83branched-chain amino acid catabolic process (GO:0009083)2.93879035
84regulation of sulfur metabolic process (GO:0042762)2.92598187
85regulation of translational fidelity (GO:0006450)2.91439904
86regulation of acyl-CoA biosynthetic process (GO:0050812)2.90782627
877-methylguanosine mRNA capping (GO:0006370)2.90373811
88negative regulation of striated muscle cell apoptotic process (GO:0010664)2.90034602
89spliceosomal snRNP assembly (GO:0000387)2.90028509
90positive regulation of transcription regulatory region DNA binding (GO:2000679)2.89133321
91transcription elongation from RNA polymerase III promoter (GO:0006385)2.88117617
92termination of RNA polymerase III transcription (GO:0006386)2.88117617
93IMP biosynthetic process (GO:0006188)2.85260454
94membrane disassembly (GO:0030397)2.83610695
95nuclear envelope disassembly (GO:0051081)2.83610695
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.83528407
977-methylguanosine RNA capping (GO:0009452)2.83511318
98RNA capping (GO:0036260)2.83511318
99nucleotide-excision repair, DNA gap filling (GO:0006297)2.81919337
100histone exchange (GO:0043486)2.77993236

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83507709
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.07536958
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64743048
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.25884545
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69055730
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.57636504
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.46873306
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.23797387
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13422314
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97600506
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.79555983
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.79402094
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74003282
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70476001
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63889952
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52115469
17VDR_23849224_ChIP-Seq_CD4+_Human2.51124344
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.48156004
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46144487
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35677744
21ELK1_19687146_ChIP-ChIP_HELA_Human2.34479212
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.33847571
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32896279
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.29221401
25DCP1A_22483619_ChIP-Seq_HELA_Human2.28846703
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26163322
27YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25481820
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24502341
29FOXP3_21729870_ChIP-Seq_TREG_Human2.19904311
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.18373891
31FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13981102
32TTF2_22483619_ChIP-Seq_HELA_Human2.04557183
33MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03000404
34AR_21909140_ChIP-Seq_LNCAP_Human2.01934013
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01390071
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99240485
37E2F1_21310950_ChIP-Seq_MCF-7_Human1.91258154
38GABP_19822575_ChIP-Seq_HepG2_Human1.90818948
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86773251
40XRN2_22483619_ChIP-Seq_HELA_Human1.83072547
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.79850984
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75245273
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.67429681
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64363644
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59876423
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.58809637
47MYC_18940864_ChIP-ChIP_HL60_Human1.58456500
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57830768
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54819055
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54188851
51KDM5A_27292631_Chip-Seq_BREAST_Human1.51640958
52POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39404969
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24593761
54IGF1R_20145208_ChIP-Seq_DFB_Human1.23964766
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21625317
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20952365
57E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19942299
58ZNF263_19887448_ChIP-Seq_K562_Human1.19107567
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18994359
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18230925
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18038810
62DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16505555
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13955117
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13857755
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13560711
66ZNF274_21170338_ChIP-Seq_K562_Hela1.13320499
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11290882
68EWS_26573619_Chip-Seq_HEK293_Human1.10749219
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10369928
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05026162
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.02736157
72CIITA_25753668_ChIP-Seq_RAJI_Human1.00201809
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99401061
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98782578
75CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98223479
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.97692618
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93802752
78NANOG_16153702_ChIP-ChIP_HESCs_Human0.93449938
79HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90438133
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.87718284
81NOTCH1_21737748_ChIP-Seq_TLL_Human0.85719635
82ELK1_22589737_ChIP-Seq_MCF10A_Human0.84729125
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84694208
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83293736
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82950079
86VDR_22108803_ChIP-Seq_LS180_Human0.81769063
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78588382
88SOX2_16153702_ChIP-ChIP_HESCs_Human0.77293328
89TFEB_21752829_ChIP-Seq_HELA_Human0.77109099
90TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.76487358
91SOX17_20123909_ChIP-Seq_XEN_Mouse0.74998233
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.73165448
93ELF1_17652178_ChIP-ChIP_JURKAT_Human0.71680221
94HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69046615
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68046934
96IRF1_19129219_ChIP-ChIP_H3396_Human0.66349475
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.65861303
98NANOG_21062744_ChIP-ChIP_HESCs_Human0.63689703
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.61268615
100TP53_22573176_ChIP-Seq_HFKS_Human0.60754629

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.87471160
2MP0009697_abnormal_copulation3.72083868
3MP0008058_abnormal_DNA_repair3.70642688
4MP0003806_abnormal_nucleotide_metabolis3.48527780
5MP0006292_abnormal_olfactory_placode3.35173517
6MP0004957_abnormal_blastocyst_morpholog3.24647496
7MP0003693_abnormal_embryo_hatching2.91974322
8MP0003111_abnormal_nucleus_morphology2.86345018
9MP0002102_abnormal_ear_morphology2.75080026
10MP0003077_abnormal_cell_cycle2.71156981
11MP0003221_abnormal_cardiomyocyte_apopto2.68678830
12MP0003718_maternal_effect2.61524816
13MP0002822_catalepsy2.54440853
14MP0001661_extended_life_span2.41785421
15MP0008932_abnormal_embryonic_tissue2.26747264
16MP0001529_abnormal_vocalization2.21184554
17MP0005187_abnormal_penis_morphology2.17568170
18MP0008057_abnormal_DNA_replication2.08494297
19MP0001730_embryonic_growth_arrest1.90577118
20MP0000749_muscle_degeneration1.87298189
21MP0003122_maternal_imprinting1.85459419
22MP0003786_premature_aging1.84637572
23MP0003121_genomic_imprinting1.78755559
24MP0002132_abnormal_respiratory_system1.74453064
25MP0008007_abnormal_cellular_replicative1.73413312
26MP0002938_white_spotting1.68467201
27MP0006035_abnormal_mitochondrial_morpho1.65995682
28MP0003890_abnormal_embryonic-extraembry1.62651821
29MP0001697_abnormal_embryo_size1.58771156
30MP0003937_abnormal_limbs/digits/tail_de1.56061333
31MP0009672_abnormal_birth_weight1.51158162
32MP0001293_anophthalmia1.51006353
33MP0004147_increased_porphyrin_level1.50656549
34MP0003567_abnormal_fetal_cardiomyocyte1.47844845
35MP0005380_embryogenesis_phenotype1.47473563
36MP0001672_abnormal_embryogenesis/_devel1.47473563
37MP0000350_abnormal_cell_proliferation1.41917705
38MP0000358_abnormal_cell_content/1.39230785
39MP0000428_abnormal_craniofacial_morphol1.37726016
40MP0003828_pulmonary_edema1.34201426
41MP0008995_early_reproductive_senescence1.32604548
42MP0008877_abnormal_DNA_methylation1.31163076
43MP0003984_embryonic_growth_retardation1.26674306
44MP0003315_abnormal_perineum_morphology1.24934331
45MP0006036_abnormal_mitochondrial_physio1.22908593
46MP0002080_prenatal_lethality1.22492010
47MP0001727_abnormal_embryo_implantation1.22460764
48MP0002210_abnormal_sex_determination1.20712027
49MP0002088_abnormal_embryonic_growth/wei1.20586417
50MP0002084_abnormal_developmental_patter1.19182586
51MP0005645_abnormal_hypothalamus_physiol1.17050076
52MP0004197_abnormal_fetal_growth/weight/1.16642908
53MP0001929_abnormal_gametogenesis1.13795957
54MP0005636_abnormal_mineral_homeostasis1.13209022
55MP0000372_irregular_coat_pigmentation1.10468708
56MP0002396_abnormal_hematopoietic_system1.08356188
57MP0001286_abnormal_eye_development1.06965021
58MP0003123_paternal_imprinting1.04940466
59MP0002111_abnormal_tail_morphology1.03433310
60MP0001145_abnormal_male_reproductive1.02826921
61MP0002085_abnormal_embryonic_tissue1.01628883
62MP0000490_abnormal_crypts_of1.00197106
63MP0001915_intracranial_hemorrhage0.99517783
64MP0001764_abnormal_homeostasis0.99107577
65MP0000647_abnormal_sebaceous_gland0.98414904
66MP0000653_abnormal_sex_gland0.96871106
67MP0010307_abnormal_tumor_latency0.96368579
68MP0002086_abnormal_extraembryonic_tissu0.94675782
69MP0003119_abnormal_digestive_system0.92525613
70MP0002160_abnormal_reproductive_system0.91220979
71MP0000313_abnormal_cell_death0.89532980
72MP0009703_decreased_birth_body0.88720730
73MP0003698_abnormal_male_reproductive0.88674698
74MP0001849_ear_inflammation0.86428310
75MP0001986_abnormal_taste_sensitivity0.86131060
76MP0000631_abnormal_neuroendocrine_gland0.85144441
77MP0001299_abnormal_eye_distance/0.85112578
78MP0002697_abnormal_eye_size0.84855503
79MP0003938_abnormal_ear_development0.83032828
80MP0006072_abnormal_retinal_apoptosis0.82459544
81MP0002233_abnormal_nose_morphology0.80775002
82MP0006054_spinal_hemorrhage0.80666018
83MP0002638_abnormal_pupillary_reflex0.75255213
84MP0002751_abnormal_autonomic_nervous0.75201250
85MP0005220_abnormal_exocrine_pancreas0.73765672
86MP0010234_abnormal_vibrissa_follicle0.73418976
87MP0000569_abnormal_digit_pigmentation0.73017313
88MP0002876_abnormal_thyroid_physiology0.71916472
89MP0002161_abnormal_fertility/fecundity0.69114042
90MP0002269_muscular_atrophy0.68919171
91MP0005647_abnormal_sex_gland0.68585389
92MP0010630_abnormal_cardiac_muscle0.67767077
93MP0005253_abnormal_eye_physiology0.67702271
94MP0005391_vision/eye_phenotype0.63811501
95MP0002282_abnormal_trachea_morphology0.63650202
96MP0005451_abnormal_body_composition0.62221161
97MP0000613_abnormal_salivary_gland0.61907656
98MP0005395_other_phenotype0.61628447
99MP0000639_abnormal_adrenal_gland0.60923428
100MP0005334_abnormal_fat_pad0.59077101

Predicted human phenotypes

RankGene SetZ-score
1Increased serum pyruvate (HP:0003542)5.80001524
2Abnormality of glycolysis (HP:0004366)5.31220173
3Abnormal mitochondria in muscle tissue (HP:0008316)4.56184095
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.55649639
5Acute necrotizing encephalopathy (HP:0006965)4.53234593
6Chromsome breakage (HP:0040012)4.34261395
7Diaphragmatic weakness (HP:0009113)4.04797832
8Pendular nystagmus (HP:0012043)3.99122543
9Progressive macrocephaly (HP:0004481)3.85452348
10Acute encephalopathy (HP:0006846)3.78879566
11Cerebral edema (HP:0002181)3.68559146
12Abnormality of methionine metabolism (HP:0010901)3.54646438
13Increased CSF lactate (HP:0002490)3.38508889
14Meckel diverticulum (HP:0002245)3.24033710
15Abnormality of the ileum (HP:0001549)3.10127233
16Mitochondrial inheritance (HP:0001427)3.07548988
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.93147771
18Decreased activity of mitochondrial respiratory chain (HP:0008972)2.93147771
19Exercise intolerance (HP:0003546)2.87001202
20Absent radius (HP:0003974)2.84420851
21Increased serum lactate (HP:0002151)2.76990552
22Septo-optic dysplasia (HP:0100842)2.73023519
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.66059633
24Absent forearm bone (HP:0003953)2.64733579
25Aplasia involving forearm bones (HP:0009822)2.64733579
26Hepatocellular necrosis (HP:0001404)2.62536389
27Axonal loss (HP:0003447)2.58573097
28Abnormality of the preputium (HP:0100587)2.57672697
29Microvesicular hepatic steatosis (HP:0001414)2.57465391
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54814066
31Abnormality of alanine metabolism (HP:0010916)2.54814066
32Hyperalaninemia (HP:0003348)2.54814066
33Lactic acidosis (HP:0003128)2.54387598
34Duplicated collecting system (HP:0000081)2.53852068
35Unilateral renal agenesis (HP:0000122)2.50517366
36Hepatic necrosis (HP:0002605)2.46995487
37Reticulocytopenia (HP:0001896)2.45627889
38Abnormality of the anterior horn cell (HP:0006802)2.43679926
39Degeneration of anterior horn cells (HP:0002398)2.43679926
40Progressive external ophthalmoplegia (HP:0000590)2.43585520
41Type I transferrin isoform profile (HP:0003642)2.42603855
42Submucous cleft hard palate (HP:0000176)2.39797131
43Acanthocytosis (HP:0001927)2.39385133
44Abnormality of chromosome stability (HP:0003220)2.38498883
45Median cleft lip (HP:0000161)2.29427515
46Triphalangeal thumb (HP:0001199)2.25995000
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20190835
48X-linked dominant inheritance (HP:0001423)2.19971940
49Birth length less than 3rd percentile (HP:0003561)2.19845169
50Supernumerary spleens (HP:0009799)2.19552216
51Abnormality of the renal collecting system (HP:0004742)2.18830964
52Leukodystrophy (HP:0002415)2.18105960
53Respiratory failure (HP:0002878)2.18001965
54Optic disc pallor (HP:0000543)2.16747809
55High anterior hairline (HP:0009890)2.15681693
56Ragged-red muscle fibers (HP:0003200)2.14586630
57Increased hepatocellular lipid droplets (HP:0006565)2.13556577
58Increased intramyocellular lipid droplets (HP:0012240)2.09874045
59Small intestinal stenosis (HP:0012848)2.05761867
60Duodenal stenosis (HP:0100867)2.05761867
61Lipid accumulation in hepatocytes (HP:0006561)2.01924976
62Nephroblastoma (Wilms tumor) (HP:0002667)2.00573131
63Pancreatic islet-cell hyperplasia (HP:0004510)2.00179912
64Ectopic kidney (HP:0000086)1.99581780
65Hypobetalipoproteinemia (HP:0003563)1.97763026
66Abnormality of the duodenum (HP:0002246)1.94935379
67Alacrima (HP:0000522)1.94436296
68Abnormality of DNA repair (HP:0003254)1.94369729
69Cerebral hypomyelination (HP:0006808)1.93853940
70Absent thumb (HP:0009777)1.92968945
71Nasal speech (HP:0001611)1.90130719
72Progressive muscle weakness (HP:0003323)1.90051626
73Decreased lacrimation (HP:0000633)1.89105853
74Abnormal protein glycosylation (HP:0012346)1.88904862
75Abnormal glycosylation (HP:0012345)1.88904862
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.88904862
77Abnormal protein N-linked glycosylation (HP:0012347)1.88904862
78Proximal tubulopathy (HP:0000114)1.86357391
79Tubulointerstitial nephritis (HP:0001970)1.85755561
80Posterior subcapsular cataract (HP:0007787)1.85065262
81Methylmalonic acidemia (HP:0002912)1.85017644
82Abnormal gallbladder physiology (HP:0012438)1.84110080
83Cholecystitis (HP:0001082)1.84110080
84Embryonal renal neoplasm (HP:0011794)1.82809029
85Renal agenesis (HP:0000104)1.82154147
86Abnormality of the carotid arteries (HP:0005344)1.79716205
87Abnormal number of incisors (HP:0011064)1.79661755
88Duplication of thumb phalanx (HP:0009942)1.76605993
89Abnormality of sulfur amino acid metabolism (HP:0004339)1.76563415
90Abnormal lung lobation (HP:0002101)1.75691271
91Bifid tongue (HP:0010297)1.75211326
92Ureteral duplication (HP:0000073)1.75181409
93Dysphonia (HP:0001618)1.74296655
94Increased muscle lipid content (HP:0009058)1.73595763
95Lethargy (HP:0001254)1.73306814
96Myelodysplasia (HP:0002863)1.72938971
97Neuroblastic tumors (HP:0004376)1.71571845
98Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.71571845
99Neuroblastoma (HP:0003006)1.71571845
100Primitive neuroectodermal tumor (HP:0030065)1.71571845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK56.36955654
2MKNK23.44942762
3EIF2AK33.40537264
4TSSK63.32725613
5BCKDK3.08473151
6BUB13.05851693
7MKNK13.02596273
8PKN22.71332562
9CDC72.69749420
10PLK42.55178113
11WNK32.42852196
12NEK12.30792333
13SRPK12.30065466
14ZAK2.19058640
15FLT32.09790075
16TTK2.03231238
17NME11.97937237
18BRD41.97716757
19PDK21.96583460
20PLK31.92666081
21PBK1.92582282
22TNIK1.83015204
23PLK21.74195453
24EIF2AK11.70762441
25TRIM281.67596793
26BCR1.56247613
27FGFR11.42368824
28CHEK21.30665233
29STK161.22027919
30WEE11.19058546
31ATR1.12992908
32VRK11.06999249
33PLK11.04319716
34AKT31.02585626
35EEF2K0.98605163
36NUAK10.96505770
37BRAF0.95905336
38LATS10.94800031
39ERBB30.88935144
40CLK10.88559320
41RPS6KB20.88101183
42MST40.86599884
43STK38L0.86394731
44NME20.83593882
45VRK20.83187874
46BRSK20.75613199
47ATM0.75395005
48EPHA40.75201695
49SCYL20.71801791
50CHEK10.71549527
51CSNK1A1L0.68648705
52AURKB0.67336735
53PASK0.66636571
54CSNK1G30.66570822
55PNCK0.66378044
56WNK40.63684002
57ARAF0.58766218
58CSNK2A20.58280377
59PAK40.51753306
60CDK10.51583467
61CSNK1G20.50321632
62CDK140.50017274
63CDK80.49648701
64CDK20.49576291
65CSNK1E0.49537082
66CDK70.47763008
67MINK10.46640782
68CSNK2A10.45970067
69CCNB10.44529528
70CSNK1G10.44379294
71RAF10.41820293
72FGR0.41340347
73BMPR1B0.40475750
74CDK180.40049828
75BRSK10.39714863
76ALK0.39189752
77PAK10.36318538
78RPS6KA50.36112136
79MAP3K40.34632121
80AKT20.33913365
81CDK11A0.33720916
82TLK10.32187577
83CDK150.32071317
84TESK20.31042995
85KDR0.30698949
86MAPKAPK30.30619714
87MAP3K80.30292098
88CDK120.29857862
89SIK30.28353383
90EIF2AK20.28337776
91FRK0.27589682
92MAP2K40.27216873
93AURKA0.26680643
94CSNK1D0.26024713
95STK30.25324703
96CDK40.24624064
97MAP3K50.24381969
98OBSCN0.24290814
99STK390.24238897
100INSRR0.22597963

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.93903848
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.70157788
3DNA replication_Homo sapiens_hsa030303.67773539
4Mismatch repair_Homo sapiens_hsa034303.11314305
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00842120
6Spliceosome_Homo sapiens_hsa030402.92351659
7RNA polymerase_Homo sapiens_hsa030202.57093243
8RNA transport_Homo sapiens_hsa030132.52890975
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.45089198
10Non-homologous end-joining_Homo sapiens_hsa034502.39658260
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34464032
12Homologous recombination_Homo sapiens_hsa034402.29403375
13Propanoate metabolism_Homo sapiens_hsa006402.20422687
14Pyruvate metabolism_Homo sapiens_hsa006202.20386882
15Protein export_Homo sapiens_hsa030602.18856321
16Fanconi anemia pathway_Homo sapiens_hsa034602.11643437
17RNA degradation_Homo sapiens_hsa030182.08024213
18Base excision repair_Homo sapiens_hsa034102.00497537
19Parkinsons disease_Homo sapiens_hsa050121.97004733
20Nucleotide excision repair_Homo sapiens_hsa034201.95573380
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89309097
22Cell cycle_Homo sapiens_hsa041101.79291363
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70901337
24Oxidative phosphorylation_Homo sapiens_hsa001901.64246086
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.64048638
26Basal transcription factors_Homo sapiens_hsa030221.59156535
27Pyrimidine metabolism_Homo sapiens_hsa002401.57717595
28Vitamin B6 metabolism_Homo sapiens_hsa007501.56745369
29mRNA surveillance pathway_Homo sapiens_hsa030151.56638787
30Ribosome_Homo sapiens_hsa030101.54137937
31Huntingtons disease_Homo sapiens_hsa050161.47980937
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47326323
33Carbon metabolism_Homo sapiens_hsa012001.46990255
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.45581126
35Folate biosynthesis_Homo sapiens_hsa007901.43325464
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40967793
37Purine metabolism_Homo sapiens_hsa002301.35683034
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.27911312
39One carbon pool by folate_Homo sapiens_hsa006701.25179777
40Steroid biosynthesis_Homo sapiens_hsa001001.21374330
41Biosynthesis of amino acids_Homo sapiens_hsa012301.18466210
42Legionellosis_Homo sapiens_hsa051341.15885271
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.09256455
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03992837
45Alzheimers disease_Homo sapiens_hsa050100.96457470
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94697008
47Epstein-Barr virus infection_Homo sapiens_hsa051690.92968889
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92574060
49Oocyte meiosis_Homo sapiens_hsa041140.91531123
50Fatty acid metabolism_Homo sapiens_hsa012120.87793665
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82993053
52Fatty acid elongation_Homo sapiens_hsa000620.78113225
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77390898
54Sulfur relay system_Homo sapiens_hsa041220.71788660
55Fatty acid biosynthesis_Homo sapiens_hsa000610.70440869
56Selenocompound metabolism_Homo sapiens_hsa004500.67690162
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66726642
58N-Glycan biosynthesis_Homo sapiens_hsa005100.63911398
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62772156
60p53 signaling pathway_Homo sapiens_hsa041150.56222985
61Sulfur metabolism_Homo sapiens_hsa009200.52219299
62Metabolic pathways_Homo sapiens_hsa011000.51190603
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50495735
64Nicotine addiction_Homo sapiens_hsa050330.48911590
65Butanoate metabolism_Homo sapiens_hsa006500.47745547
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45658488
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44563525
68Glutathione metabolism_Homo sapiens_hsa004800.38422105
69Adherens junction_Homo sapiens_hsa045200.37821962
70Thyroid cancer_Homo sapiens_hsa052160.37335721
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36225252
72Cardiac muscle contraction_Homo sapiens_hsa042600.35449303
73Taste transduction_Homo sapiens_hsa047420.33029391
74Alcoholism_Homo sapiens_hsa050340.32817304
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32748516
76Pentose phosphate pathway_Homo sapiens_hsa000300.31317688
77Regulation of autophagy_Homo sapiens_hsa041400.31153543
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.30954734
79Systemic lupus erythematosus_Homo sapiens_hsa053220.29781683
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28625724
81Wnt signaling pathway_Homo sapiens_hsa043100.28397606
82Antigen processing and presentation_Homo sapiens_hsa046120.28212937
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25897928
84Fructose and mannose metabolism_Homo sapiens_hsa000510.24627131
85Vitamin digestion and absorption_Homo sapiens_hsa049770.22704671
86Nitrogen metabolism_Homo sapiens_hsa009100.21891136
87Measles_Homo sapiens_hsa051620.21432263
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19900492
89Lysine degradation_Homo sapiens_hsa003100.18017160
90Viral carcinogenesis_Homo sapiens_hsa052030.17664394
91HIF-1 signaling pathway_Homo sapiens_hsa040660.15988529
92Influenza A_Homo sapiens_hsa051640.14877857
93Arginine biosynthesis_Homo sapiens_hsa002200.14606067
94Fat digestion and absorption_Homo sapiens_hsa049750.13930754
95Estrogen signaling pathway_Homo sapiens_hsa049150.11161832
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.10564428
97Fatty acid degradation_Homo sapiens_hsa000710.10414062
98Hedgehog signaling pathway_Homo sapiens_hsa043400.10292607
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.10023118
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.08506583

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