NET1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.29589709
2DNA unwinding involved in DNA replication (GO:0006268)5.01428844
3embryonic process involved in female pregnancy (GO:0060136)4.75211981
4nuclear pore organization (GO:0006999)4.55741776
5Golgi transport vesicle coating (GO:0048200)4.26045945
6COPI coating of Golgi vesicle (GO:0048205)4.26045945
7hemidesmosome assembly (GO:0031581)4.02712793
8growth hormone receptor signaling pathway (GO:0060396)4.01509694
9sulfur amino acid catabolic process (GO:0000098)3.98834485
10proline biosynthetic process (GO:0006561)3.89781939
11interferon-gamma secretion (GO:0072643)3.86260490
12NIK/NF-kappaB signaling (GO:0038061)3.80170182
13mitotic chromosome condensation (GO:0007076)3.76823437
14pore complex assembly (GO:0046931)3.75532832
15regulation of integrin activation (GO:0033623)3.58763623
16ribosome assembly (GO:0042255)3.48609749
17cellular response to growth hormone stimulus (GO:0071378)3.45726520
18diterpenoid biosynthetic process (GO:0016102)3.44249493
19regulation of cholesterol homeostasis (GO:2000188)3.39056940
20desmosome organization (GO:0002934)3.36827590
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31270111
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.31270111
23mitotic sister chromatid segregation (GO:0000070)3.28505559
24regulation of protein homooligomerization (GO:0032462)3.25974473
25positive regulation of protein homooligomerization (GO:0032464)3.25070889
26antigen processing and presentation of endogenous antigen (GO:0019883)3.24984341
27intestinal cholesterol absorption (GO:0030299)3.23797451
28sister chromatid segregation (GO:0000819)3.23310191
29gap junction assembly (GO:0016264)3.19893005
30regulation of mitotic spindle organization (GO:0060236)3.19389855
31low-density lipoprotein particle clearance (GO:0034383)3.18780998
32cellular response to lithium ion (GO:0071285)3.18366889
33mitotic sister chromatid cohesion (GO:0007064)3.18268642
34formation of translation preinitiation complex (GO:0001731)3.17587617
35proline metabolic process (GO:0006560)3.14984547
36regulation of translational fidelity (GO:0006450)3.06924257
37positive regulation of protein oligomerization (GO:0032461)3.06399244
38COPII vesicle coating (GO:0048208)3.05599858
39negative regulation of fatty acid biosynthetic process (GO:0045717)3.04612572
40positive regulation of fatty acid beta-oxidation (GO:0032000)3.02739412
41establishment of integrated proviral latency (GO:0075713)3.02366406
42regulation of RNA export from nucleus (GO:0046831)3.00944187
43DNA topological change (GO:0006265)2.99235889
44valine metabolic process (GO:0006573)2.98793049
45regulation of water loss via skin (GO:0033561)2.96992532
46regulation of cholesterol storage (GO:0010885)2.93912083
47regulation of RIG-I signaling pathway (GO:0039535)2.93905769
48embryonic placenta development (GO:0001892)2.89589233
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85937669
50keratinocyte proliferation (GO:0043616)2.84876910
51negative regulation of keratinocyte proliferation (GO:0010839)2.84276797
52intestinal absorption (GO:0050892)2.83227907
53DNA strand elongation involved in DNA replication (GO:0006271)2.80278056
54mitotic nuclear envelope disassembly (GO:0007077)2.78267408
55regulation of protein oligomerization (GO:0032459)2.78098267
56negative regulation of protein oligomerization (GO:0032460)2.78003491
57DNA strand elongation (GO:0022616)2.77131158
58protein localization to chromosome, centromeric region (GO:0071459)2.76338782
59mitotic metaphase plate congression (GO:0007080)2.75886708
60negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.75710969
61positive regulation of natural killer cell differentiation (GO:0032825)2.74593187
62establishment of apical/basal cell polarity (GO:0035089)2.73850424
63phospholipid efflux (GO:0033700)2.73800443
64triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.73316419
65establishment of skin barrier (GO:0061436)2.72641635
66protein localization to kinetochore (GO:0034501)2.72281103
67nucleotide-sugar biosynthetic process (GO:0009226)2.72057861
68heterochromatin organization (GO:0070828)2.70721424
69tight junction assembly (GO:0070830)2.70003680
70cellular protein complex localization (GO:0034629)2.68517017
71chromosome condensation (GO:0030261)2.68432167
72DNA replication initiation (GO:0006270)2.67708608
73regulation of triglyceride catabolic process (GO:0010896)2.66599945
74hepatocyte apoptotic process (GO:0097284)2.66329555
75very-low-density lipoprotein particle assembly (GO:0034379)2.65933754
76NADH metabolic process (GO:0006734)2.65295095
77urea cycle (GO:0000050)2.64977006
78urea metabolic process (GO:0019627)2.64977006
79protein retention in ER lumen (GO:0006621)2.64326109
80bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63552799
81regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.62806826
82regulation of spindle organization (GO:0090224)2.62612557
83epithelial cell-cell adhesion (GO:0090136)2.62006931
84acylglycerol homeostasis (GO:0055090)2.61299434
85triglyceride homeostasis (GO:0070328)2.61299434
86nuclear envelope disassembly (GO:0051081)2.61144948
87membrane disassembly (GO:0030397)2.61144948
88DNA replication checkpoint (GO:0000076)2.60597964
89multicellular organismal water homeostasis (GO:0050891)2.60419088
90positive regulation of fatty acid oxidation (GO:0046321)2.58449171
91protein complex localization (GO:0031503)2.56146487
92regulation of nucleobase-containing compound transport (GO:0032239)2.56011663
93phospholipid homeostasis (GO:0055091)2.55779073
94trophectodermal cell differentiation (GO:0001829)2.54936984
95response to growth hormone (GO:0060416)2.54345722
96kynurenine metabolic process (GO:0070189)2.54229467
97plasma lipoprotein particle assembly (GO:0034377)2.53924874
98positive regulation of lipid catabolic process (GO:0050996)2.53742597
99regulation of sterol transport (GO:0032371)2.53072340
100regulation of cholesterol transport (GO:0032374)2.53072340
101positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.52632973
102DNA duplex unwinding (GO:0032508)2.50807151
103positive regulation of epidermal cell differentiation (GO:0045606)2.50269876
104cysteine metabolic process (GO:0006534)2.49820766
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.48528066
106negative regulation of cell fate specification (GO:0009996)2.48292836
107terpenoid biosynthetic process (GO:0016114)2.47375143
108branching involved in mammary gland duct morphogenesis (GO:0060444)2.46870450
109notochord development (GO:0030903)2.46600645
110vesicle coating (GO:0006901)2.46577105
111positive regulation of endothelial cell apoptotic process (GO:2000353)2.46411220
112regulation of centriole replication (GO:0046599)2.46292319
113alpha-linolenic acid metabolic process (GO:0036109)2.45676803
114lipoprotein metabolic process (GO:0042157)2.45297699
115negative regulation of DNA repair (GO:0045738)2.44420999
116cell-substrate junction assembly (GO:0007044)2.43954381
117regulation of fatty acid beta-oxidation (GO:0031998)2.43658432
118tryptophan catabolic process (GO:0006569)2.42332424
119indole-containing compound catabolic process (GO:0042436)2.42332424
120indolalkylamine catabolic process (GO:0046218)2.42332424
121nitrogen cycle metabolic process (GO:0071941)2.42238320
122positive regulation of DNA-dependent DNA replication (GO:2000105)2.41835104
123regulation of T cell tolerance induction (GO:0002664)2.38249953
124metaphase plate congression (GO:0051310)2.37878904
125cholesterol efflux (GO:0033344)2.37776280
126protein-lipid complex assembly (GO:0065005)2.37301391
127regulation of translational termination (GO:0006449)2.36205473
128cellular response to zinc ion (GO:0071294)2.36204500
129DNA geometric change (GO:0032392)2.36184799
130cholesterol homeostasis (GO:0042632)2.35399220
131complement activation, alternative pathway (GO:0006957)2.34914433
132cytoskeletal anchoring at plasma membrane (GO:0007016)2.34176083
133DNA conformation change (GO:0071103)2.33925116
134DNA packaging (GO:0006323)2.33890080
135serine family amino acid catabolic process (GO:0009071)2.33840609
136sterol homeostasis (GO:0055092)2.33494503
137glyoxylate metabolic process (GO:0046487)2.33382247
138nucleobase-containing small molecule interconversion (GO:0015949)2.32880568
139regulation of sister chromatid cohesion (GO:0007063)2.32749353
140telomere maintenance via semi-conservative replication (GO:0032201)2.32491789
141fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.31674476
142phospholipid scrambling (GO:0017121)2.31400175
143cell-cell junction assembly (GO:0007043)2.31372036
144hypotonic response (GO:0006971)2.31345303
145skin morphogenesis (GO:0043589)2.31124066
146regulation of cardioblast differentiation (GO:0051890)2.30597144
147protein maturation by protein folding (GO:0022417)2.30264571
148regulation of metalloenzyme activity (GO:0048552)2.28676116
149tryptophan metabolic process (GO:0006568)2.27656665
150UDP-N-acetylglucosamine metabolic process (GO:0006047)2.27645161
151regulation of cholesterol esterification (GO:0010872)2.26573560
152amino-acid betaine metabolic process (GO:0006577)2.26146970
153folic acid-containing compound biosynthetic process (GO:0009396)2.25784012
154regulation of histone H3-K27 methylation (GO:0061085)2.25741926
155glutamine family amino acid biosynthetic process (GO:0009084)2.25530080
156mitotic cytokinesis (GO:0000281)2.25524663
157dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.25262535
158endothelial cell chemotaxis (GO:0035767)2.25169842
159high-density lipoprotein particle remodeling (GO:0034375)2.24887506
160homocysteine metabolic process (GO:0050667)2.24536913
161negative regulation of cholesterol transport (GO:0032375)2.24441234
162negative regulation of sterol transport (GO:0032372)2.24441234
163mesodermal cell differentiation (GO:0048333)2.24412116
164L-phenylalanine metabolic process (GO:0006558)2.23792433
165erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.23792433
166protein export from nucleus (GO:0006611)2.23688911
167positive regulation of sterol transport (GO:0032373)2.23015643
168positive regulation of cholesterol transport (GO:0032376)2.23015643
169embryonic camera-type eye development (GO:0031076)2.21908315
170biotin metabolic process (GO:0006768)2.21600616
171fatty acid transmembrane transport (GO:1902001)2.21375634
172protein localization to microtubule (GO:0035372)2.21045966
173regulation of hypersensitivity (GO:0002883)2.20956670
174regulation of natural killer cell differentiation (GO:0032823)2.20177034
175hormone catabolic process (GO:0042447)2.20101618
176regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.19628362
177plasma lipoprotein particle clearance (GO:0034381)2.19585142
178positive regulation of cholesterol efflux (GO:0010875)2.19480589
179embryonic eye morphogenesis (GO:0048048)2.19293246
180regulation of keratinocyte differentiation (GO:0045616)2.18878633
181regulation of sequestering of triglyceride (GO:0010889)2.18620059
182nuclear envelope organization (GO:0006998)2.18424628
183negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.17740445
184hepatocyte differentiation (GO:0070365)2.17479146
185intestinal epithelial cell development (GO:0060576)2.17225466

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.18394045
2E2F7_22180533_ChIP-Seq_HELA_Human6.48132791
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.99565696
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.73121960
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.52257587
6STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.38230608
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.28011121
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.18063615
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.11884029
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.94676751
11* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80876226
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.73205530
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.67678375
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.57363648
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.45871134
16ZNF263_19887448_ChIP-Seq_K562_Human2.43570448
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28930135
18* CLOCK_20551151_ChIP-Seq_293T_Human2.25252425
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.24724459
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14636231
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.04737359
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98206172
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96837940
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.95588933
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.95085905
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92820442
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91678999
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.86379486
29CDX2_20551321_ChIP-Seq_CACO-2_Human1.83963298
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.83609983
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.81333017
32* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74913195
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74043273
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70450092
35ESR1_15608294_ChIP-ChIP_MCF-7_Human1.68440213
36* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65245541
37KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64056572
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.63473902
39SOX2_27498859_Chip-Seq_STOMACH_Mouse1.63359309
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62975954
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.62010116
42FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61741203
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61111531
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60957624
45RACK7_27058665_Chip-Seq_MCF-7_Human1.57144747
46MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56752392
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56318903
48GATA6_25053715_ChIP-Seq_YYC3_Human1.55379244
49FOXO3_23340844_ChIP-Seq_DLD1_Human1.52523310
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.51526543
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.50200275
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47616076
53VDR_21846776_ChIP-Seq_THP-1_Human1.46513604
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45524896
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44923387
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44247868
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43640795
58ELK3_25401928_ChIP-Seq_HUVEC_Human1.42778145
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41965073
60TCF3_18692474_ChIP-Seq_MEFs_Mouse1.41618069
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41390624
62TRIM28_21343339_ChIP-Seq_HEK293_Human1.40450798
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40426200
64TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38261120
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37366434
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37347750
67XRN2_22483619_ChIP-Seq_HELA_Human1.36161864
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35525813
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34940733
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.33664550
71MAF_26560356_Chip-Seq_TH1_Human1.33520619
72TCF7_22412390_ChIP-Seq_EML_Mouse1.31248357
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30940512
74ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30878313
75GATA4_25053715_ChIP-Seq_YYC3_Human1.29977714
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.29181090
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29071583
78ESR1_20079471_ChIP-ChIP_T-47D_Human1.28453820
79GATA3_24758297_ChIP-Seq_MCF-7_Human1.28140299
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28010176
81KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26787482
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25971319
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24635939
84POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23969870
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.23125685
86* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22751084
87* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22751084
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21000087
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20603900
90DCP1A_22483619_ChIP-Seq_HELA_Human1.20418867
91NCOR1_26117541_ChIP-Seq_K562_Human1.17492380
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16974895
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16375257
94ATF3_27146783_Chip-Seq_COLON_Human1.16013557
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15704378
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13647014
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13094635
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.12399369
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11911734
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11239184
101KDM2B_26808549_Chip-Seq_DND41_Human1.10935774
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10758016
103* RUNX1_27514584_Chip-Seq_MCF-7_Human1.10095039
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09761794
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09524233
106KDM5A_27292631_Chip-Seq_BREAST_Human1.08777986
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08759183
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07736464
109LXR_22292898_ChIP-Seq_THP-1_Human1.06786288
110TTF2_22483619_ChIP-Seq_HELA_Human1.06095900
111TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04724231
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04308604
113SOX2_20726797_ChIP-Seq_SW620_Human1.04210686
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03861754
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02932708
116MYC_22102868_ChIP-Seq_BL_Human1.02396387
117NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02306744
118SOX17_20123909_ChIP-Seq_XEN_Mouse1.01177166
119BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01037665
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00444171
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00260676
122UBF1/2_26484160_Chip-Seq_HMECs_Human0.99681300
123STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99383095
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98357963
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98304577
126* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98179781
127PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97852224
128CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97501400
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97352483
130ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97255277
131IRF8_21731497_ChIP-ChIP_J774_Mouse0.97069093
132KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.97041863
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96191607
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96191607
135ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95340436
136SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95279093
137SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95273637
138GATA1_22025678_ChIP-Seq_K562_Human0.94855910
139TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93179978
140YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92814110
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92674007
142POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92619285
143THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92559176
144SALL1_21062744_ChIP-ChIP_HESCs_Human0.92260072
145ELF5_23300383_ChIP-Seq_T47D_Human0.92053680
146TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.91909150
147* CHD1_26751641_Chip-Seq_LNCaP_Human0.90477132
148HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87734406
149AR_21909140_ChIP-Seq_LNCAP_Human0.87411694
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86451895
151KDM2B_26808549_Chip-Seq_JURKAT_Human0.86404889
152* MYB_26560356_Chip-Seq_TH1_Human0.86125573
153VDR_24763502_ChIP-Seq_THP-1_Human0.85673959
154KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84015143

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.24460548
2MP0005360_urolithiasis3.12504043
3MP0002009_preneoplasia3.09330313
4MP0003693_abnormal_embryo_hatching2.84343726
5MP0010234_abnormal_vibrissa_follicle2.82196914
6MP0002138_abnormal_hepatobiliary_system2.80793973
7MP0003705_abnormal_hypodermis_morpholog2.78801939
8MP0004957_abnormal_blastocyst_morpholog2.75352416
9MP0002796_impaired_skin_barrier2.60421542
10MP0004264_abnormal_extraembryonic_tissu2.43774851
11MP0002139_abnormal_hepatobiliary_system2.35165078
12MP0005085_abnormal_gallbladder_physiolo2.30934344
13MP0005365_abnormal_bile_salt2.29245080
14MP0003453_abnormal_keratinocyte_physiol2.28318314
15MP0010352_gastrointestinal_tract_polyps2.27313037
16MP0004185_abnormal_adipocyte_glucose2.15247559
17MP0002166_altered_tumor_susceptibility2.13707156
18MP0005076_abnormal_cell_differentiation2.05904083
19MP0000685_abnormal_immune_system2.02751108
20MP0003111_abnormal_nucleus_morphology2.02136759
21MP0000566_synostosis1.99713301
22MP0002060_abnormal_skin_morphology1.84085883
23MP0010094_abnormal_chromosome_stability1.74964000
24MP0001346_abnormal_lacrimal_gland1.72101162
25MP0003077_abnormal_cell_cycle1.71132826
26MP0008875_abnormal_xenobiotic_pharmacok1.68724464
27MP0008932_abnormal_embryonic_tissue1.68704296
28MP0004272_abnormal_basement_membrane1.66833641
29MP0003252_abnormal_bile_duct1.66408737
30MP0000678_abnormal_parathyroid_gland1.65949223
31MP0005275_abnormal_skin_tensile1.61652688
32MP0010329_abnormal_lipoprotein_level1.61016396
33MP0003566_abnormal_cell_adhesion1.59024870
34MP0001730_embryonic_growth_arrest1.58858368
35MP0009840_abnormal_foam_cell1.58181332
36MP0002006_tumorigenesis1.57185048
37MP0005501_abnormal_skin_physiology1.54447886
38MP0003191_abnormal_cellular_cholesterol1.52423677
39MP0003315_abnormal_perineum_morphology1.51230504
40MP0002877_abnormal_melanocyte_morpholog1.50924317
41MP0000350_abnormal_cell_proliferation1.49762716
42MP0005666_abnormal_adipose_tissue1.49054629
43MP0009697_abnormal_copulation1.48412537
44MP0001666_abnormal_nutrient_absorption1.45684623
45MP0000579_abnormal_nail_morphology1.45210809
46MP0009780_abnormal_chondrocyte_physiolo1.42844283
47MP0001216_abnormal_epidermal_layer1.42775127
48MP0004947_skin_inflammation1.41893175
49MP0001873_stomach_inflammation1.41616861
50MP0004019_abnormal_vitamin_homeostasis1.39968613
51MP0010030_abnormal_orbit_morphology1.39664019
52MP0005409_darkened_coat_color1.39479286
53MP0003950_abnormal_plasma_membrane1.34189381
54MP0009278_abnormal_bone_marrow1.31984679
55MP0009053_abnormal_anal_canal1.30853930
56MP0001672_abnormal_embryogenesis/_devel1.29028189
57MP0005380_embryogenesis_phenotype1.29028189
58MP0005670_abnormal_white_adipose1.27410234
59MP0003984_embryonic_growth_retardation1.26537326
60MP0004782_abnormal_surfactant_physiolog1.22623735
61MP0002088_abnormal_embryonic_growth/wei1.21465428
62MP0010678_abnormal_skin_adnexa1.21411633
63MP0000609_abnormal_liver_physiology1.21101699
64MP0001697_abnormal_embryo_size1.19999512
65MP0002080_prenatal_lethality1.19746866
66MP0008007_abnormal_cellular_replicative1.19216749
67MP0010155_abnormal_intestine_physiology1.18394864
68MP0003941_abnormal_skin_development1.17976553
69MP0001835_abnormal_antigen_presentation1.16842685
70MP0002084_abnormal_developmental_patter1.15425410
71MP0002098_abnormal_vibrissa_morphology1.15287057
72MP0001348_abnormal_lacrimal_gland1.14729519
73MP0000537_abnormal_urethra_morphology1.14559877
74MP0000383_abnormal_hair_follicle1.13619353
75MP0002085_abnormal_embryonic_tissue1.13413673
76MP0008057_abnormal_DNA_replication1.11849322
77MP0001545_abnormal_hematopoietic_system1.11709873
78MP0005397_hematopoietic_system_phenotyp1.11709873
79MP0009115_abnormal_fat_cell1.11434708
80MP0005023_abnormal_wound_healing1.07321462
81MP0003937_abnormal_limbs/digits/tail_de1.06724072
82MP0000627_abnormal_mammary_gland1.05435266
83MP0004233_abnormal_muscle_weight1.01416751
84MP0009672_abnormal_birth_weight0.99433795
85MP0002971_abnormal_brown_adipose0.99108431
86MP0000467_abnormal_esophagus_morphology0.98508684
87MP0002111_abnormal_tail_morphology0.98007638
88MP0008058_abnormal_DNA_repair0.96459993
89MP0004147_increased_porphyrin_level0.96336756
90MP0004130_abnormal_muscle_cell0.96326548
91MP0000377_abnormal_hair_follicle0.96043360
92MP0005083_abnormal_biliary_tract0.95144362
93MP0001881_abnormal_mammary_gland0.94967278
94MP0005451_abnormal_body_composition0.94652008
95MP0003718_maternal_effect0.94262190
96MP0003300_gastrointestinal_ulcer0.91224772
97MP0009931_abnormal_skin_appearance0.89150559
98MP0003123_paternal_imprinting0.88603633
99MP0004197_abnormal_fetal_growth/weight/0.86947106
100MP0005375_adipose_tissue_phenotype0.85629698
101MP0001727_abnormal_embryo_implantation0.84588387
102MP0006054_spinal_hemorrhage0.84571252
103MP0005387_immune_system_phenotype0.83964170
104MP0001790_abnormal_immune_system0.83964170
105MP0001299_abnormal_eye_distance/0.82925974
106MP0000003_abnormal_adipose_tissue0.81994039
107MP0010771_integument_phenotype0.81628285
108MP0003943_abnormal_hepatobiliary_system0.81206828
109MP0000647_abnormal_sebaceous_gland0.80714827
110MP0003045_fibrosis0.80334707
111MP0002896_abnormal_bone_mineralization0.79571705
112MP0001800_abnormal_humoral_immune0.79182277
113MP0002118_abnormal_lipid_homeostasis0.78620317
114MP0001243_abnormal_dermal_layer0.78375185
115MP0009703_decreased_birth_body0.77288376
116MP0003806_abnormal_nucleotide_metabolis0.77068041
117MP0000490_abnormal_crypts_of0.76787296
118MP0003786_premature_aging0.76671428
119MP0000427_abnormal_hair_cycle0.76623493
120MP0003436_decreased_susceptibility_to0.76481477
121MP0002086_abnormal_extraembryonic_tissu0.76011847
122MP0003942_abnormal_urinary_system0.73221553
123MP0002697_abnormal_eye_size0.73140162
124MP0000462_abnormal_digestive_system0.73024606
125MP0009643_abnormal_urine_homeostasis0.72887675
126MP0000762_abnormal_tongue_morphology0.72789617
127MP0000477_abnormal_intestine_morphology0.72683024
128MP0010307_abnormal_tumor_latency0.72135288
129MP0003115_abnormal_respiratory_system0.71550840
130MP0006138_congestive_heart_failure0.70344034
131MP0001849_ear_inflammation0.69877129
132MP0000598_abnormal_liver_morphology0.69706647
133MP0005332_abnormal_amino_acid0.69436717
134MP0000371_diluted_coat_color0.69373405
135MP0005319_abnormal_enzyme/_coenzyme0.68864779
136MP0002249_abnormal_larynx_morphology0.67854626
137MP0002876_abnormal_thyroid_physiology0.67414418
138MP0003091_abnormal_cell_migration0.67196349
139MP0005334_abnormal_fat_pad0.67069900
140MP0002282_abnormal_trachea_morphology0.66657077
141MP0000367_abnormal_coat/_hair0.65507110
142MP0008438_abnormal_cutaneous_collagen0.65167467
143MP0002163_abnormal_gland_morphology0.64800659
144MP0002396_abnormal_hematopoietic_system0.64709936
145MP0001191_abnormal_skin_condition0.63873149
146MP0000858_altered_metastatic_potential0.63239909
147MP0002136_abnormal_kidney_physiology0.62413966
148MP0000613_abnormal_salivary_gland0.61788212
149MP0002452_abnormal_antigen_presenting0.61110901
150MP0000516_abnormal_urinary_system0.60708772

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)3.87512089
2Pustule (HP:0200039)3.84587375
3Myocardial infarction (HP:0001658)3.45997025
4Right ventricular cardiomyopathy (HP:0011663)3.45447869
5Ankyloglossia (HP:0010296)3.40892795
6Polycythemia (HP:0001901)3.29881050
7Milia (HP:0001056)3.26302295
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.14059735
9Flat acetabular roof (HP:0003180)3.11714175
10Plantar hyperkeratosis (HP:0007556)3.09265942
11Abnormality of nail color (HP:0100643)3.00041092
12Esophageal varix (HP:0002040)2.92856101
13Septate vagina (HP:0001153)2.92342433
14Hypotrichosis (HP:0001006)2.89616307
15Onycholysis (HP:0001806)2.84080490
16Hypobetalipoproteinemia (HP:0003563)2.80573266
17Xanthomatosis (HP:0000991)2.75632945
18Intrahepatic cholestasis (HP:0001406)2.73826267
19Hyperactive renin-angiotensin system (HP:0000841)2.71821565
20Lip pit (HP:0100267)2.68630925
21Woolly hair (HP:0002224)2.67499421
22Ulnar bowing (HP:0003031)2.67010691
23Abnormal hemoglobin (HP:0011902)2.64287717
24Hydroxyprolinuria (HP:0003080)2.62696348
25Abnormality of proline metabolism (HP:0010907)2.62696348
26Acanthosis nigricans (HP:0000956)2.61770528
27Deviation of the thumb (HP:0009603)2.60418661
28Hypolipoproteinemia (HP:0010981)2.56964440
29Abnormality of monocarboxylic acid metabolism (HP:0010996)2.55589994
30Hypochromic microcytic anemia (HP:0004840)2.55209989
31Trismus (HP:0000211)2.55064681
32Fragile nails (HP:0001808)2.54618011
33Autoimmune thrombocytopenia (HP:0001973)2.53649210
34Abnormality of the gastric mucosa (HP:0004295)2.49481035
35Deep venous thrombosis (HP:0002625)2.46947094
36Palmoplantar hyperkeratosis (HP:0000972)2.46206803
37Abnormality of oral frenula (HP:0000190)2.43651988
38Hypoalphalipoproteinemia (HP:0003233)2.43457299
39Epidermoid cyst (HP:0200040)2.39584681
40Turricephaly (HP:0000262)2.37244959
41Sparse eyelashes (HP:0000653)2.36889940
42Pili torti (HP:0003777)2.35210445
43Increased IgE level (HP:0003212)2.32507838
44Proximal placement of thumb (HP:0009623)2.32359076
45Atrophic scars (HP:0001075)2.32347198
46Palmar hyperkeratosis (HP:0010765)2.30921927
47Colitis (HP:0002583)2.27373069
48Abnormality of the distal phalanges of the toes (HP:0010182)2.19942082
49Malnutrition (HP:0004395)2.19907676
50Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19476994
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19215902
52Popliteal pterygium (HP:0009756)2.18345990
53Alveolar cell carcinoma (HP:0006519)2.18325997
54Pterygium (HP:0001059)2.17738306
55Advanced eruption of teeth (HP:0006288)2.15283127
56Neoplasm of the tracheobronchial system (HP:0100552)2.14054598
57Chromsome breakage (HP:0040012)2.13854288
58Abnormality of the salivary glands (HP:0010286)2.13775632
59Curly hair (HP:0002212)2.12736493
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.12621810
61Osteolytic defects of the hand bones (HP:0009699)2.12621810
62Nasal polyposis (HP:0100582)2.12384070
63Increased connective tissue (HP:0009025)2.11569749
64Hyperglycinuria (HP:0003108)2.10716263
65Ridged nail (HP:0001807)2.10300100
66Cortical dysplasia (HP:0002539)2.09826114
67Chronic bronchitis (HP:0004469)2.08389607
68Acute myeloid leukemia (HP:0004808)2.08350190
69Breech presentation (HP:0001623)2.07361841
70Microglossia (HP:0000171)2.06610918
71Hypochromic anemia (HP:0001931)2.05609056
72Breast hypoplasia (HP:0003187)2.02476635
73Cerebral aneurysm (HP:0004944)2.01637631
74Fragile skin (HP:0001030)2.00542100
75Nail dystrophy (HP:0008404)1.99938617
76Abnormality of the distal phalanx of the thumb (HP:0009617)1.99552937
77Abnormality of carpal bone ossification (HP:0006257)1.99292523
78Abnormality of the common coagulation pathway (HP:0010990)1.98646188
79Vascular calcification (HP:0004934)1.98583394
80Abnormal tarsal ossification (HP:0008369)1.98421553
81Increased IgM level (HP:0003496)1.97924661
82Abnormality of the neuromuscular junction (HP:0003398)1.97645937
83Fatigable weakness (HP:0003473)1.97645937
84Abnormality of the nasal mucosa (HP:0000433)1.97070571
85Complement deficiency (HP:0004431)1.96264429
86Absent eyelashes (HP:0000561)1.95326791
87Increased mean platelet volume (HP:0011877)1.94336347
88Natal tooth (HP:0000695)1.94201632
89Thick nail (HP:0001805)1.93810243
90Hyperammonemia (HP:0001987)1.93470938
91Abnormality of glycolysis (HP:0004366)1.92405275
92Increased nuchal translucency (HP:0010880)1.92075453
93Ileus (HP:0002595)1.91508071
94Abnormalities of placenta or umbilical cord (HP:0001194)1.90951384
95Spinal cord compression (HP:0002176)1.90855508
96Short nail (HP:0001799)1.90386461
97Abnormality of purine metabolism (HP:0004352)1.90343771
98Increased serum pyruvate (HP:0003542)1.89388758
99Abnormality of the umbilical cord (HP:0010881)1.89291761
100Selective tooth agenesis (HP:0001592)1.88925405
101Blepharitis (HP:0000498)1.88512135
102Hypoplastic labia majora (HP:0000059)1.88237011
103Rectal prolapse (HP:0002035)1.87766783
104Hypertriglyceridemia (HP:0002155)1.86404311
105Peritonitis (HP:0002586)1.86124563
106Missing ribs (HP:0000921)1.85723144
107Deep philtrum (HP:0002002)1.82953012
108Premature rupture of membranes (HP:0001788)1.81314836
109Asymmetry of the thorax (HP:0001555)1.80638948
110Periodontitis (HP:0000704)1.79933839
111Coronal craniosynostosis (HP:0004440)1.79271553
112Concave nail (HP:0001598)1.78707568
113Cholecystitis (HP:0001082)1.78616480
114Abnormal gallbladder physiology (HP:0012438)1.78616480
115Polygenic inheritance (HP:0010982)1.78358863
116Ureteral duplication (HP:0000073)1.78240736
117Bifid scrotum (HP:0000048)1.77822776
118Short humerus (HP:0005792)1.77812284
119Hematochezia (HP:0002573)1.76964975
120Abnormal foot bone ossification (HP:0010675)1.76530641
121Fatigue (HP:0012378)1.76422416
122Abnormal hair laboratory examination (HP:0003328)1.76053854
123Cardiovascular calcification (HP:0011915)1.75232572
124Hyporeflexia of lower limbs (HP:0002600)1.75018224
125Abnormal ossification of hand bones (HP:0005921)1.74612169
12611 pairs of ribs (HP:0000878)1.72882482
127Bowing of the arm (HP:0006488)1.70805197
128Bowed forearm bones (HP:0003956)1.70805197
129Autoimmune hemolytic anemia (HP:0001890)1.70664149
130Hemorrhage of the eye (HP:0011885)1.70493679
131Neoplasm of the lung (HP:0100526)1.70017596
132Abnormal platelet volume (HP:0011876)1.69289795
133Amelogenesis imperfecta (HP:0000705)1.68951198
134Gastrointestinal dysmotility (HP:0002579)1.68515376
135Amniotic constriction ring (HP:0009775)1.68276822
136Abnormality of placental membranes (HP:0011409)1.68276822
137Termporal pattern (HP:0011008)1.68245650
138Insidious onset (HP:0003587)1.68245650
139Sparse lateral eyebrow (HP:0005338)1.68231420
140Abnormality of the labia majora (HP:0012881)1.68166086
141Male infertility (HP:0003251)1.68039800
142Toxemia of pregnancy (HP:0100603)1.67909597
143Poikiloderma (HP:0001029)1.67442364
144Round ear (HP:0100830)1.66342409
145Acanthocytosis (HP:0001927)1.66293937
146Abnormality of the hepatic vasculature (HP:0006707)1.65493949
147Premature skin wrinkling (HP:0100678)1.64626509
148Distal lower limb amyotrophy (HP:0008944)1.64475553
149Abnormality of nucleobase metabolism (HP:0010932)1.64321410
150Short middle phalanx of finger (HP:0005819)1.64319243
151Reticulocytosis (HP:0001923)1.63910477
152Abnormal hand bone ossification (HP:0010660)1.63824437
153Hypercholesterolemia (HP:0003124)1.62614339
154Easy fatigability (HP:0003388)1.61664762
155Abnormality of complement system (HP:0005339)1.61224694
156Nephritis (HP:0000123)1.60763692
157Abnormality of aromatic amino acid family metabolism (HP:0004338)1.60637268
158Papillary thyroid carcinoma (HP:0002895)1.60422003
159Neoplasm of the respiratory system (HP:0100606)1.59316053
160Spastic diplegia (HP:0001264)1.58881832
161Recurrent fungal infections (HP:0002841)1.58737560
162Fat malabsorption (HP:0002630)1.58602891
163Growth hormone excess (HP:0000845)1.58281863
164Abnormal blistering of the skin (HP:0008066)1.58042985
165Inflammation of the large intestine (HP:0002037)1.56782986
166Sandal gap (HP:0001852)1.56643071
167Abnormality of the acetabulum (HP:0003170)1.53828844
168Abnormality of permanent molar morphology (HP:0011071)1.53806807
169Abnormality of the dental root (HP:0006486)1.53806807
170Taurodontia (HP:0000679)1.53806807
171Overlapping toe (HP:0001845)1.53310465
172Hyperacusis (HP:0010780)1.53162326
173Aplasia cutis congenita (HP:0001057)1.53104808
174Reduced subcutaneous adipose tissue (HP:0003758)1.53041480
175Abnormal umbilical cord blood vessels (HP:0011403)1.50578351
176Single umbilical artery (HP:0001195)1.50578351
177Abnormality of the fetal cardiovascular system (HP:0010948)1.50578351

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR22.65761264
2TTK2.49809196
3ICK2.48271531
4EIF2AK12.44461829
5LATS12.40588817
6TRIB32.38796231
7MAPK152.33379144
8MST1R2.16203219
9MAP3K142.16059362
10LMTK22.09327174
11FLT32.02921726
12TYK22.02688052
13BUB11.96627636
14STK101.89598201
15CDK61.89481845
16RIPK11.89181550
17IKBKB1.88890400
18FGFR41.85806031
19PBK1.84690295
20NME21.84330364
21SMG11.82477119
22EPHA21.82113896
23SCYL21.79533399
24SIK11.75707821
25PTK61.74790093
26CDC71.72914153
27PDGFRA1.71872921
28EPHB21.71057637
29ERN11.70748016
30SRPK11.68798955
31BMX1.66896600
32MAP3K111.64587226
33CHUK1.64476182
34MAP3K61.59800106
35MAP3K101.57150897
36BMPR21.54027761
37NEK11.53204905
38JAK31.52948017
39STK241.51248802
40PRKAA21.49760958
41MAP3K131.48274393
42STK31.44860688
43DMPK1.41023519
44MAP3K21.39910364
45EPHA31.39712082
46TRPM71.37179285
47GSK3A1.35696810
48LRRK21.34480753
49MST41.34419897
50MAPK111.31488769
51DYRK1B1.30433878
52TSSK61.29906348
53CDK121.29082603
54CSK1.29038412
55WEE11.24870404
56FRK1.22888483
57EIF2AK31.21267474
58MATK1.20310211
59TYRO31.18738747
60LATS21.17743834
61FGFR31.16163186
62TESK11.13158448
63FGR1.13140636
64MAP3K31.12326329
65TBK11.09899109
66EPHB11.09627900
67MAPKAPK31.08256515
68PIM11.06002680
69BRSK11.03764579
70IRAK31.03095329
71RPS6KB20.99307709
72MET0.99296258
73JAK10.96466077
74PRKD20.96014663
75CDK90.94451978
76PLK40.93123038
77NEK90.91061950
78PTK20.90275776
79AURKB0.90092459
80PIM20.89986382
81TTN0.88875932
82CAMK1D0.87585908
83MTOR0.87554764
84PAK40.84821850
85VRK20.83371409
86TGFBR20.81840252
87AKT30.81621173
88EEF2K0.80801414
89MAP3K90.80227533
90PRKAA10.79862678
91PLK10.78266272
92CDK80.78079760
93NEK20.75916323
94MKNK20.74740918
95MAP3K80.74590060
96MAP2K20.74289990
97IKBKE0.72546844
98MKNK10.71675006
99PRKG20.69758986
100MAP3K70.69633332
101PDGFRB0.68785999
102JAK20.68661093
103CHEK10.68291149
104ERBB40.68240436
105CHEK20.68093421
106MAPKAPK20.67396406
107MAP3K120.67380119
108NUAK10.67348419
109RPS6KA10.65090007
110PRKCI0.63403255
111FER0.63040496
112ILK0.61692447
113FGFR10.60892783
114BRD40.57941329
115MAP4K10.57748054
116RPS6KA40.57051897
117CLK10.56658974
118CDK70.56450927
119EIF2AK20.56447798
120PLK30.56170430
121GRK60.54412689
122TAOK10.54153312
123CAMK1G0.53920327
124BCR0.53402015
125AURKA0.52931154
126PKN20.52000811
127CDK40.51715488
128ATR0.51505569
129STK38L0.49615353
130NEK60.49582451
131STK390.49269531
132NME10.48582628
133BCKDK0.48120942
134MAP2K10.47719174
135TAF10.47491375
136PIK3CA0.47211125
137MAP3K50.47066485
138ATM0.46961265
139NTRK10.45573764
140BRAF0.45540575
141ALK0.44365226
142PRPF4B0.44096100
143TGFBR10.43215630
144FGFR20.42813489
145CDK10.42766843
146CSNK1E0.42414432
147RPS6KL10.42388200
148RPS6KC10.42388200
149MELK0.42292294
150AKT20.42116873
151PAK20.41715509
152MAPK30.41390889
153RPS6KA60.41323774
154RAF10.40609355
155KSR20.40332560
156DYRK30.39762154
157MAP2K30.39226637
158BRSK20.38329189
159CDK20.38306286

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.21947699
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.76326134
3DNA replication_Homo sapiens_hsa030302.65749886
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.59780575
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28772071
6Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21698427
7Mismatch repair_Homo sapiens_hsa034302.05342805
8Caffeine metabolism_Homo sapiens_hsa002322.04720162
9PPAR signaling pathway_Homo sapiens_hsa033202.01947773
10Primary bile acid biosynthesis_Homo sapiens_hsa001201.94750386
11Nitrogen metabolism_Homo sapiens_hsa009101.90989177
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89570097
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89104300
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89021858
15Cell cycle_Homo sapiens_hsa041101.87418495
16Arginine biosynthesis_Homo sapiens_hsa002201.86862286
17Tryptophan metabolism_Homo sapiens_hsa003801.82406427
18Fatty acid degradation_Homo sapiens_hsa000711.79962637
19Fat digestion and absorption_Homo sapiens_hsa049751.74598312
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.65913068
21Fatty acid metabolism_Homo sapiens_hsa012121.64475905
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.59698998
23Pyruvate metabolism_Homo sapiens_hsa006201.59518010
24RNA transport_Homo sapiens_hsa030131.54172280
25Spliceosome_Homo sapiens_hsa030401.53873033
26Small cell lung cancer_Homo sapiens_hsa052221.47246617
27One carbon pool by folate_Homo sapiens_hsa006701.44611101
28Phenylalanine metabolism_Homo sapiens_hsa003601.41688611
29Carbon metabolism_Homo sapiens_hsa012001.41105666
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40977000
31Pentose phosphate pathway_Homo sapiens_hsa000301.39795363
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38979729
33Adherens junction_Homo sapiens_hsa045201.37658943
34Nucleotide excision repair_Homo sapiens_hsa034201.37370159
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.29976325
36Base excision repair_Homo sapiens_hsa034101.26805860
37Vitamin digestion and absorption_Homo sapiens_hsa049771.25370765
38Tight junction_Homo sapiens_hsa045301.23361380
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21240063
40mRNA surveillance pathway_Homo sapiens_hsa030151.20890472
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.20261673
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20156790
43Complement and coagulation cascades_Homo sapiens_hsa046101.17362359
44Chemical carcinogenesis_Homo sapiens_hsa052041.15607219
45Retinol metabolism_Homo sapiens_hsa008301.10569060
46Lysine degradation_Homo sapiens_hsa003101.09859327
47Histidine metabolism_Homo sapiens_hsa003401.09631421
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09124693
49beta-Alanine metabolism_Homo sapiens_hsa004101.07280636
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.06673792
51Toxoplasmosis_Homo sapiens_hsa051451.05842011
52Hippo signaling pathway_Homo sapiens_hsa043901.05215132
53Central carbon metabolism in cancer_Homo sapiens_hsa052301.04438283
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.02078287
55TNF signaling pathway_Homo sapiens_hsa046681.00186029
56p53 signaling pathway_Homo sapiens_hsa041150.99270731
57Apoptosis_Homo sapiens_hsa042100.99085960
58Bile secretion_Homo sapiens_hsa049760.98488545
59Cyanoamino acid metabolism_Homo sapiens_hsa004600.98366423
60Starch and sucrose metabolism_Homo sapiens_hsa005000.97232070
61Selenocompound metabolism_Homo sapiens_hsa004500.95304708
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.95146193
63Peroxisome_Homo sapiens_hsa041460.95086587
64Propanoate metabolism_Homo sapiens_hsa006400.94125076
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93478184
66Folate biosynthesis_Homo sapiens_hsa007900.92474910
67Bladder cancer_Homo sapiens_hsa052190.92198640
68Chronic myeloid leukemia_Homo sapiens_hsa052200.90742106
69MicroRNAs in cancer_Homo sapiens_hsa052060.89240419
70Acute myeloid leukemia_Homo sapiens_hsa052210.88064310
71Vitamin B6 metabolism_Homo sapiens_hsa007500.88007009
72TGF-beta signaling pathway_Homo sapiens_hsa043500.86494691
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85114442
74Renin-angiotensin system_Homo sapiens_hsa046140.85060836
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85052675
76Steroid biosynthesis_Homo sapiens_hsa001000.84295132
77ABC transporters_Homo sapiens_hsa020100.83747733
78Fatty acid elongation_Homo sapiens_hsa000620.83565876
79Endometrial cancer_Homo sapiens_hsa052130.83469058
80Proteoglycans in cancer_Homo sapiens_hsa052050.82850080
81Proteasome_Homo sapiens_hsa030500.81159899
82Glutathione metabolism_Homo sapiens_hsa004800.80561871
83Insulin resistance_Homo sapiens_hsa049310.80217969
84N-Glycan biosynthesis_Homo sapiens_hsa005100.79588622
85Notch signaling pathway_Homo sapiens_hsa043300.78711234
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78610304
87AMPK signaling pathway_Homo sapiens_hsa041520.78309881
88Staphylococcus aureus infection_Homo sapiens_hsa051500.77692499
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77366501
90Pancreatic cancer_Homo sapiens_hsa052120.77357380
91Tyrosine metabolism_Homo sapiens_hsa003500.75598107
92Thyroid cancer_Homo sapiens_hsa052160.75510723
93Fructose and mannose metabolism_Homo sapiens_hsa000510.74999315
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74272971
95Antigen processing and presentation_Homo sapiens_hsa046120.74227505
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.73622820
97Pyrimidine metabolism_Homo sapiens_hsa002400.72358951
98Non-homologous end-joining_Homo sapiens_hsa034500.71603444
99Prostate cancer_Homo sapiens_hsa052150.71591842
100Biosynthesis of amino acids_Homo sapiens_hsa012300.71434999
101Insulin signaling pathway_Homo sapiens_hsa049100.70218936
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.69249265
103Herpes simplex infection_Homo sapiens_hsa051680.69073963
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67308614
105Sulfur metabolism_Homo sapiens_hsa009200.66328848
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66154847
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65817952
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65711873
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65561007
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64949024
111Protein digestion and absorption_Homo sapiens_hsa049740.64941826
112mTOR signaling pathway_Homo sapiens_hsa041500.64832163
113Viral myocarditis_Homo sapiens_hsa054160.64453203
114Renal cell carcinoma_Homo sapiens_hsa052110.64304091
115Homologous recombination_Homo sapiens_hsa034400.64155854
116Shigellosis_Homo sapiens_hsa051310.64069706
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63135097
118Mineral absorption_Homo sapiens_hsa049780.63102113
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60977428
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60762587
121Glycerolipid metabolism_Homo sapiens_hsa005610.60367687
122Basal cell carcinoma_Homo sapiens_hsa052170.60115059
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.59985185
124Hepatitis C_Homo sapiens_hsa051600.59545948
125Measles_Homo sapiens_hsa051620.58989609
126Arginine and proline metabolism_Homo sapiens_hsa003300.58948614
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58589286
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58272165
129Non-small cell lung cancer_Homo sapiens_hsa052230.57767812
130Viral carcinogenesis_Homo sapiens_hsa052030.57365751
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57235170
132ErbB signaling pathway_Homo sapiens_hsa040120.57209226
133Leishmaniasis_Homo sapiens_hsa051400.55481638
134NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55284891
135Focal adhesion_Homo sapiens_hsa045100.55146319
136Legionellosis_Homo sapiens_hsa051340.54468931
137Circadian rhythm_Homo sapiens_hsa047100.53771150
138Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52420067
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51593193
140Osteoclast differentiation_Homo sapiens_hsa043800.51164734
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50714914
142Oocyte meiosis_Homo sapiens_hsa041140.49833788
143Galactose metabolism_Homo sapiens_hsa000520.48209144
144Sulfur relay system_Homo sapiens_hsa041220.47241395
145ECM-receptor interaction_Homo sapiens_hsa045120.46505232

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »