NETO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)6.32259781
2synaptic vesicle exocytosis (GO:0016079)6.05531070
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.95918165
4* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.84480220
5locomotory exploration behavior (GO:0035641)5.76692262
6synaptic vesicle maturation (GO:0016188)5.61904639
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.55420490
8cerebellar granule cell differentiation (GO:0021707)5.36042294
9regulation of glutamate receptor signaling pathway (GO:1900449)5.32360965
10cerebellar Purkinje cell layer development (GO:0021680)5.29428000
11glutamate secretion (GO:0014047)5.12088134
12ionotropic glutamate receptor signaling pathway (GO:0035235)5.08467969
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04829013
14neuron cell-cell adhesion (GO:0007158)4.98964476
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.83433152
16regulation of synaptic vesicle exocytosis (GO:2000300)4.81434128
17* protein localization to synapse (GO:0035418)4.80363466
18regulation of synapse structural plasticity (GO:0051823)4.68663404
19neurotransmitter-gated ion channel clustering (GO:0072578)4.59123643
20negative regulation of glycogen biosynthetic process (GO:0045719)4.58221246
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.57213387
22neuronal action potential propagation (GO:0019227)4.55013662
23exploration behavior (GO:0035640)4.54882469
24* regulation of long-term neuronal synaptic plasticity (GO:0048169)4.52967074
25synaptic transmission, glutamatergic (GO:0035249)4.52684770
26neurotransmitter secretion (GO:0007269)4.50528255
27* regulation of neuronal synaptic plasticity (GO:0048168)4.47782806
28glutamate receptor signaling pathway (GO:0007215)4.37196230
29regulation of synaptic vesicle transport (GO:1902803)4.36343870
30neuron-neuron synaptic transmission (GO:0007270)4.33173488
31biotin metabolic process (GO:0006768)4.30153156
32iron ion import (GO:0097286)4.28143351
33positive regulation of synapse maturation (GO:0090129)4.22219616
34import into cell (GO:0098657)4.12619905
35dendritic spine morphogenesis (GO:0060997)4.10735041
36layer formation in cerebral cortex (GO:0021819)4.08565304
37long-term memory (GO:0007616)4.05450077
38prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.04644091
39* regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03126916
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.00285614
41gamma-aminobutyric acid transport (GO:0015812)3.98266499
42regulation of dendritic spine morphogenesis (GO:0061001)3.88511171
43* positive regulation of membrane potential (GO:0045838)3.85305418
44* regulation of synaptic plasticity (GO:0048167)3.83660896
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83414951
46sodium ion export (GO:0071436)3.82419438
47branching involved in prostate gland morphogenesis (GO:0060442)3.81628688
48negative regulation of synaptic transmission, GABAergic (GO:0032229)3.78549812
49* regulation of postsynaptic membrane potential (GO:0060078)3.78428098
50long-term synaptic potentiation (GO:0060291)3.76785615
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.74181970
52proline transport (GO:0015824)3.72928782
53transmission of nerve impulse (GO:0019226)3.72635738
54positive regulation of synaptic transmission, GABAergic (GO:0032230)3.71793329
55regulation of synaptic transmission, glutamatergic (GO:0051966)3.71260932
56neuron recognition (GO:0008038)3.70321264
57L-amino acid import (GO:0043092)3.61943027
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.59738238
59neurotransmitter transport (GO:0006836)3.56435463
60L-serine metabolic process (GO:0006563)3.56352294
61negative regulation of glycogen metabolic process (GO:0070874)3.55309115
62G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.52925161
63striatum development (GO:0021756)3.51221092
64neuromuscular process controlling balance (GO:0050885)3.49424856
65startle response (GO:0001964)3.43311798
66auditory behavior (GO:0031223)3.41028949
67prepulse inhibition (GO:0060134)3.39601272
68regulation of neurotransmitter levels (GO:0001505)3.37045345
69insulin-like growth factor receptor signaling pathway (GO:0048009)3.36056672
70behavioral defense response (GO:0002209)3.35803221
71behavioral fear response (GO:0001662)3.35803221
72positive regulation of neurotransmitter transport (GO:0051590)3.35578890
73postsynaptic membrane organization (GO:0001941)3.35054351
74gamma-aminobutyric acid signaling pathway (GO:0007214)3.31521438
75response to histamine (GO:0034776)3.31276533
76cellular potassium ion homeostasis (GO:0030007)3.30654824
77* learning (GO:0007612)3.30647766
78regulation of neurotransmitter secretion (GO:0046928)3.30180064
79neuronal ion channel clustering (GO:0045161)3.29756996
80response to auditory stimulus (GO:0010996)3.29525647
81regulation of vesicle fusion (GO:0031338)3.28790638
82activation of protein kinase A activity (GO:0034199)3.28470110
83amino acid import (GO:0043090)3.28199861
84positive regulation of neurotransmitter secretion (GO:0001956)3.27640055
85beta-amyloid metabolic process (GO:0050435)3.27188702
86behavioral response to cocaine (GO:0048148)3.26257209
87potassium ion import (GO:0010107)3.25283541
88presynaptic membrane assembly (GO:0097105)3.24448412
89regulation of dendritic spine development (GO:0060998)3.24420766
90axonal fasciculation (GO:0007413)3.23500428
91membrane hyperpolarization (GO:0060081)3.23357775
92* membrane depolarization (GO:0051899)3.23073143
93regulation of synapse maturation (GO:0090128)3.22700192
94potassium ion homeostasis (GO:0055075)3.21006914
95positive regulation of synaptic transmission (GO:0050806)3.20189188
96synaptic vesicle endocytosis (GO:0048488)3.20048430
97regulation of synaptic transmission, GABAergic (GO:0032228)3.19597703
98synapse assembly (GO:0007416)3.18618390
99regulation of ARF protein signal transduction (GO:0032012)3.18579484
100regulation of glutamate secretion (GO:0014048)3.17592881
101positive regulation of dendritic spine morphogenesis (GO:0061003)3.14355886
102negative regulation of dendrite morphogenesis (GO:0050774)3.13971894
103regulation of neurotransmitter transport (GO:0051588)3.12583032
104dendrite morphogenesis (GO:0048813)3.11316395
105neuromuscular process (GO:0050905)3.11210476
106intraspecies interaction between organisms (GO:0051703)3.11036821
107social behavior (GO:0035176)3.11036821
108regulation of female receptivity (GO:0045924)3.10922825
109* regulation of synaptic transmission (GO:0050804)3.09825541
110positive regulation of dendritic spine development (GO:0060999)3.08977234
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.07539746
112synaptic transmission (GO:0007268)3.07438065
113presynaptic membrane organization (GO:0097090)3.07395060
114dendritic spine organization (GO:0097061)3.06695401
115fear response (GO:0042596)3.04546248
116detection of calcium ion (GO:0005513)3.04236408
117adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.02872130
118positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01472417
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01092812
120cerebellar Purkinje cell differentiation (GO:0021702)3.00892598
121epithelial cell maturation (GO:0002070)2.98869389
122cell differentiation in hindbrain (GO:0021533)2.98537135
123cytoskeletal anchoring at plasma membrane (GO:0007016)2.96383717
124membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.90010556
125regulation of NFAT protein import into nucleus (GO:0051532)2.86046083
126regulation of clathrin-mediated endocytosis (GO:2000369)2.85285729
127positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.75177224
128apical protein localization (GO:0045176)2.73586376
129cellular response to electrical stimulus (GO:0071257)2.73408125
130positive regulation of histone deacetylation (GO:0031065)2.68469983
131neurotransmitter catabolic process (GO:0042135)2.68025782
132cell communication by electrical coupling (GO:0010644)2.62628324
133anterior/posterior axis specification, embryo (GO:0008595)2.61012263
134positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.60895688
135vascular endothelial growth factor signaling pathway (GO:0038084)2.59800281
136dicarboxylic acid transport (GO:0006835)2.58779154
137cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58692619
138regulation of receptor binding (GO:1900120)2.54131447
139serotonin metabolic process (GO:0042428)2.52924996
140cellular sodium ion homeostasis (GO:0006883)2.52185721
141membrane repolarization during action potential (GO:0086011)2.52079283
142peptidyl-tyrosine autophosphorylation (GO:0038083)2.51417674
143protein import into peroxisome matrix (GO:0016558)2.48737047
144cell communication involved in cardiac conduction (GO:0086065)2.48191873
145respiratory system process (GO:0003016)2.42797952
146* visual learning (GO:0008542)2.40217391
147negative regulation of glucose import (GO:0046325)2.39672191
148replicative senescence (GO:0090399)2.39381273
149regulation of potassium ion transmembrane transport (GO:1901379)2.38568500
150membrane repolarization (GO:0086009)2.38248453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.50830061
2AR_21909140_ChIP-Seq_LNCAP_Human4.19545481
3GBX2_23144817_ChIP-Seq_PC3_Human3.93670037
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.26171380
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.20702358
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14580897
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.77051008
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75997974
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75997974
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73368072
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70617800
12* REST_21632747_ChIP-Seq_MESCs_Mouse2.67022217
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60953982
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54696219
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54115379
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.52620108
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50754881
18* CHD1_26751641_Chip-Seq_LNCaP_Human2.46050354
19DROSHA_22980978_ChIP-Seq_HELA_Human2.44696804
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27699317
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26968006
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.21361906
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20220757
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.18367499
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11955556
26* AR_21572438_ChIP-Seq_LNCaP_Human1.98718236
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97840361
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.94708937
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.94511014
30KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.94511014
31KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.94511014
32TAF15_26573619_Chip-Seq_HEK293_Human1.91347819
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.89456172
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82869367
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82336062
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82238270
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82136965
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81645755
39* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75178290
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73030421
41SMAD4_21799915_ChIP-Seq_A2780_Human1.70910612
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70279375
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.65679904
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.59576543
45CREB1_26743006_Chip-Seq_LNCaP_Human1.56857247
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55746682
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52992289
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51112099
49AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.49822450
50P300_19829295_ChIP-Seq_ESCs_Human1.48225292
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47492408
52* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44377690
53ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42636767
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.40583666
55VDR_22108803_ChIP-Seq_LS180_Human1.40161704
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38535097
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.36559913
58* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33255075
59AR_25329375_ChIP-Seq_VCAP_Human1.31890636
60ZNF274_21170338_ChIP-Seq_K562_Hela1.30888513
61* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30089101
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.29921059
63ZNF263_19887448_ChIP-Seq_K562_Human1.29601386
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.29534516
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28769587
66FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.28247627
67STAT3_23295773_ChIP-Seq_U87_Human1.27350923
68* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26950044
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26768024
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26472184
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.26013992
72* CBX2_27304074_Chip-Seq_ESCs_Mouse1.24172146
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.22241357
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21568355
75* PIAS1_25552417_ChIP-Seq_VCAP_Human1.20798289
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.20575549
77* AR_19668381_ChIP-Seq_PC3_Human1.20500294
78* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20281342
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.20257107
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16497251
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.15362468
82WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14689401
83FUS_26573619_Chip-Seq_HEK293_Human1.13893406
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12503597
85* SOX9_26525672_Chip-Seq_HEART_Mouse1.11937596
86POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11699077
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.10894753
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10655992
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10033031
90* TCF4_23295773_ChIP-Seq_U87_Human1.09664641
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08701087
92* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08388128
93STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07842668
94* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07675482
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07637369
96AHR_22903824_ChIP-Seq_MCF-7_Human1.07348957
97* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06412882
98KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06312969
99TET1_21490601_ChIP-Seq_MESCs_Mouse1.06151244
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05992978
101* RNF2_27304074_Chip-Seq_NSC_Mouse1.03840296
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.02647663
103CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02388821
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02047654
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.01625816
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01495303
107IGF1R_20145208_ChIP-Seq_DFB_Human1.01021967
108RUNX2_22187159_ChIP-Seq_PCA_Human1.00847223
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.00310955
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00142189
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99457390
112* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99104970
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98837390
114SMAD3_21741376_ChIP-Seq_HESCs_Human0.98707242
115TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98482894
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98090301
117ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97761214
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97477043
119WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.96923768
120JUN_21703547_ChIP-Seq_K562_Human0.96769928
121ER_23166858_ChIP-Seq_MCF-7_Human0.95798250
122TP53_16413492_ChIP-PET_HCT116_Human0.94718223
123TP53_20018659_ChIP-ChIP_R1E_Mouse0.94034039
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.93984004
125POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.93574408
126SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93115398
127GATA1_26923725_Chip-Seq_HPCs_Mouse0.93103111
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.91800816
129ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91125731
130TP53_18474530_ChIP-ChIP_U2OS_Human0.90745854
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.90550249
132RXR_22108803_ChIP-Seq_LS180_Human0.90259843
133* BCAT_22108803_ChIP-Seq_LS180_Human0.90209837
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90077102
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90033670
136KDM2B_26808549_Chip-Seq_K562_Human0.89197339
137TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88686319
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88599887
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88599887
140PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88331079
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87865678
142POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85844048
143RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84352066
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83910219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.91026987
2MP0003880_abnormal_central_pattern4.87428763
3MP0002822_catalepsy4.47412844
4* MP0003635_abnormal_synaptic_transmissio4.39323921
5MP0003123_paternal_imprinting3.86690709
6MP0004270_analgesia3.65505123
7MP0009745_abnormal_behavioral_response3.64378314
8* MP0002063_abnormal_learning/memory/cond3.56267706
9* MP0002064_seizures3.27410830
10MP0009046_muscle_twitch3.02936596
11MP0002572_abnormal_emotion/affect_behav2.98688972
12MP0001968_abnormal_touch/_nociception2.97456836
13MP0001486_abnormal_startle_reflex2.71153586
14MP0000537_abnormal_urethra_morphology2.62055230
15MP0002272_abnormal_nervous_system2.61709007
16MP0005423_abnormal_somatic_nervous2.59445616
17MP0002009_preneoplasia2.55599176
18MP0002734_abnormal_mechanical_nocicepti2.53057447
19MP0002735_abnormal_chemical_nociception2.43435922
20MP0001501_abnormal_sleep_pattern2.34070835
21MP0002736_abnormal_nociception_after2.31405002
22MP0001440_abnormal_grooming_behavior2.11676434
23MP0002733_abnormal_thermal_nociception2.00714745
24MP0001970_abnormal_pain_threshold1.96466367
25MP0002067_abnormal_sensory_capabilities1.92914203
26MP0003705_abnormal_hypodermis_morpholog1.87392224
27MP0003121_genomic_imprinting1.86415702
28MP0008569_lethality_at_weaning1.84251389
29MP0004811_abnormal_neuron_physiology1.79446445
30MP0004924_abnormal_behavior1.78886710
31MP0005386_behavior/neurological_phenoty1.78886710
32MP0009780_abnormal_chondrocyte_physiolo1.78640388
33MP0004858_abnormal_nervous_system1.77831240
34MP0002557_abnormal_social/conspecific_i1.76191750
35MP0005646_abnormal_pituitary_gland1.74805295
36MP0000778_abnormal_nervous_system1.74127173
37MP0002909_abnormal_adrenal_gland1.73814009
38MP0002184_abnormal_innervation1.71472066
39MP0003329_amyloid_beta_deposits1.69532568
40MP0003879_abnormal_hair_cell1.66954307
41MP0001529_abnormal_vocalization1.60408009
42MP0001984_abnormal_olfaction1.58657541
43MP0000955_abnormal_spinal_cord1.47901774
44MP0003315_abnormal_perineum_morphology1.45359569
45MP0002066_abnormal_motor_capabilities/c1.42768792
46MP0003787_abnormal_imprinting1.41238760
47MP0003283_abnormal_digestive_organ1.39217686
48MP0002882_abnormal_neuron_morphology1.39117901
49MP0005647_abnormal_sex_gland1.36659469
50MP0003941_abnormal_skin_development1.36263387
51MP0006276_abnormal_autonomic_nervous1.35981409
52MP0004885_abnormal_endolymph1.34284786
53MP0003633_abnormal_nervous_system1.28259654
54MP0000534_abnormal_ureter_morphology1.24189068
55MP0001188_hyperpigmentation1.21110358
56MP0002249_abnormal_larynx_morphology1.19710711
57MP0008877_abnormal_DNA_methylation1.17657201
58MP0008057_abnormal_DNA_replication1.16910030
59MP0001905_abnormal_dopamine_level1.16138738
60MP0004142_abnormal_muscle_tone1.14453659
61MP0001502_abnormal_circadian_rhythm1.13668706
62MP0005645_abnormal_hypothalamus_physiol1.12057691
63MP0002152_abnormal_brain_morphology1.09981062
64MP0003631_nervous_system_phenotype1.09589926
65MP0005451_abnormal_body_composition1.09149310
66MP0001177_atelectasis1.06053450
67MP0003890_abnormal_embryonic-extraembry1.03884832
68MP0008874_decreased_physiological_sensi1.00819688
69MP0008872_abnormal_physiological_respon0.99097612
70MP0000751_myopathy0.98395978
71MP0000566_synostosis0.98020025
72MP0002069_abnormal_eating/drinking_beha0.96190805
73MP0000569_abnormal_digit_pigmentation0.93158936
74MP0003075_altered_response_to0.92012484
75MP0005220_abnormal_exocrine_pancreas0.91875389
76MP0009672_abnormal_birth_weight0.91720579
77MP0002837_dystrophic_cardiac_calcinosis0.88317332
78MP0003122_maternal_imprinting0.87552800
79MP0002229_neurodegeneration0.87335769
80MP0002166_altered_tumor_susceptibility0.87136330
81MP0005551_abnormal_eye_electrophysiolog0.87109375
82MP0004085_abnormal_heartbeat0.86306955
83MP0004185_abnormal_adipocyte_glucose0.86071760
84MP0004742_abnormal_vestibular_system0.85531231
85MP0009250_abnormal_appendicular_skeleto0.85150875
86MP0002090_abnormal_vision0.81035893
87MP0001963_abnormal_hearing_physiology0.80631876
88MP0000579_abnormal_nail_morphology0.80436671
89MP0005187_abnormal_penis_morphology0.79328139
90MP0003690_abnormal_glial_cell0.79278665
91MP0005535_abnormal_body_temperature0.79048182
92MP0004197_abnormal_fetal_growth/weight/0.78799181
93MP0005623_abnormal_meninges_morphology0.78220148
94MP0005310_abnormal_salivary_gland0.78106780
95MP0003634_abnormal_glial_cell0.77728280
96MP0010234_abnormal_vibrissa_follicle0.76871221
97MP0003942_abnormal_urinary_system0.75940150
98MP0000013_abnormal_adipose_tissue0.75054314
99MP0004215_abnormal_myocardial_fiber0.74981962
100MP0003632_abnormal_nervous_system0.74671405
101MP0005394_taste/olfaction_phenotype0.74421528
102MP0005499_abnormal_olfactory_system0.74421528
103MP0000604_amyloidosis0.74083338
104MP0002006_tumorigenesis0.73912534
105MP0003011_delayed_dark_adaptation0.72541626
106MP0000747_muscle_weakness0.72492793
107MP0000920_abnormal_myelination0.72165183
108MP0004484_altered_response_of0.71933692
109MP0008961_abnormal_basal_metabolism0.71403062
110MP0005409_darkened_coat_color0.70194762
111MP0000631_abnormal_neuroendocrine_gland0.69900989
112MP0002752_abnormal_somatic_nervous0.69054536
113MP0002081_perinatal_lethality0.67675963
114MP0010386_abnormal_urinary_bladder0.66460012
115MP0000026_abnormal_inner_ear0.65420788
116MP0003137_abnormal_impulse_conducting0.64825478
117MP0000613_abnormal_salivary_gland0.64375661
118MP0001664_abnormal_digestion0.63013736
119MP0001485_abnormal_pinna_reflex0.62135395
120MP0005167_abnormal_blood-brain_barrier0.62129855
121MP0004145_abnormal_muscle_electrophysio0.60032299
122MP0002876_abnormal_thyroid_physiology0.57828660
123MP0004510_myositis0.56169650
124MP0003172_abnormal_lysosome_physiology0.56050543
125MP0001943_abnormal_respiration0.55422517
126MP0002638_abnormal_pupillary_reflex0.54715398
127MP0003861_abnormal_nervous_system0.54038252
128MP0010769_abnormal_survival0.53978609
129MP0002082_postnatal_lethality0.51823647
130MP0010770_preweaning_lethality0.51823647
131MP0003956_abnormal_body_size0.50766069
132MP0010768_mortality/aging0.50584572
133MP0004233_abnormal_muscle_weight0.50179396

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.58373270
2Myokymia (HP:0002411)7.61907409
3Focal seizures (HP:0007359)6.16113686
4Epileptic encephalopathy (HP:0200134)5.15898782
5Visual hallucinations (HP:0002367)5.15660012
6Atonic seizures (HP:0010819)4.68715941
7Progressive cerebellar ataxia (HP:0002073)4.36728918
8Febrile seizures (HP:0002373)4.34935472
9Sparse lateral eyebrow (HP:0005338)4.33658800
10Absence seizures (HP:0002121)4.31289990
11Dialeptic seizures (HP:0011146)4.07653089
12Generalized tonic-clonic seizures (HP:0002069)4.06088683
13Neonatal hypoglycemia (HP:0001998)4.05860054
14Hyperventilation (HP:0002883)4.01255649
15Broad-based gait (HP:0002136)3.80169301
16Impaired vibration sensation in the lower limbs (HP:0002166)3.65298956
17Abnormality of secondary sexual hair (HP:0009888)3.63083287
18Abnormality of the axillary hair (HP:0100134)3.63083287
19Poor eye contact (HP:0000817)3.61912150
20Action tremor (HP:0002345)3.61841632
21Abnormal social behavior (HP:0012433)3.55550997
22Impaired social interactions (HP:0000735)3.55550997
23Gaze-evoked nystagmus (HP:0000640)3.50295581
24Dysdiadochokinesis (HP:0002075)3.30281755
25Depression (HP:0000716)3.26658308
26Ankle clonus (HP:0011448)3.22141638
27Supranuclear gaze palsy (HP:0000605)3.20819435
28Papilledema (HP:0001085)3.18235068
29Urinary bladder sphincter dysfunction (HP:0002839)3.17511829
30Truncal ataxia (HP:0002078)3.15728357
31Dysmetria (HP:0001310)3.15645635
32Overgrowth (HP:0001548)3.14143832
33Anxiety (HP:0000739)3.08013078
34Amblyopia (HP:0000646)3.01578565
35Mutism (HP:0002300)3.00555515
36Postural instability (HP:0002172)2.94806428
37Abnormal eating behavior (HP:0100738)2.94072726
38Torticollis (HP:0000473)2.93202147
39Progressive inability to walk (HP:0002505)2.92159375
40Excessive salivation (HP:0003781)2.91068929
41Drooling (HP:0002307)2.91068929
42Gonadotropin excess (HP:0000837)2.87848995
43Germ cell neoplasia (HP:0100728)2.83324090
44Focal dystonia (HP:0004373)2.82549114
45Scanning speech (HP:0002168)2.79989472
46Calf muscle hypertrophy (HP:0008981)2.69818051
47Genetic anticipation (HP:0003743)2.68337216
48Urinary urgency (HP:0000012)2.68114255
49Epileptiform EEG discharges (HP:0011182)2.65550728
50Abnormality of the fingertips (HP:0001211)2.65089953
51Stereotypic behavior (HP:0000733)2.61954473
52Impaired smooth pursuit (HP:0007772)2.59348359
53Absent speech (HP:0001344)2.57208735
54Long palpebral fissure (HP:0000637)2.51724286
55Spastic gait (HP:0002064)2.51433162
56Impaired vibratory sensation (HP:0002495)2.50597230
57Shallow orbits (HP:0000586)2.50072654
58Abnormality of the lower motor neuron (HP:0002366)2.48145802
59Status epilepticus (HP:0002133)2.46206946
60Craniofacial dystonia (HP:0012179)2.46035079
61Hemiparesis (HP:0001269)2.45468360
62Bradykinesia (HP:0002067)2.45064779
63Generalized myoclonic seizures (HP:0002123)2.44649821
64EEG with generalized epileptiform discharges (HP:0011198)2.44324410
65Cerebral inclusion bodies (HP:0100314)2.43240443
66Inability to walk (HP:0002540)2.42410522
67Glossoptosis (HP:0000162)2.42298090
68Diplopia (HP:0000651)2.42283657
69Abnormality of binocular vision (HP:0011514)2.42283657
70Insidious onset (HP:0003587)2.41370748
71Termporal pattern (HP:0011008)2.41370748
72Annular pancreas (HP:0001734)2.36757112
73Intention tremor (HP:0002080)2.35353983
74Resting tremor (HP:0002322)2.34916655
75Hypsarrhythmia (HP:0002521)2.32648684
76Aplasia/Hypoplasia of the sternum (HP:0006714)2.32132056
77Abnormality of ocular smooth pursuit (HP:0000617)2.31630067
78Abnormality of homocysteine metabolism (HP:0010919)2.28213504
79Homocystinuria (HP:0002156)2.28213504
80Neurofibrillary tangles (HP:0002185)2.27513253
81Dysmetric saccades (HP:0000641)2.26262994
82Muscle hypertrophy of the lower extremities (HP:0008968)2.24967076
83Polyphagia (HP:0002591)2.24674921
84Testicular atrophy (HP:0000029)2.24213267
85Fetal akinesia sequence (HP:0001989)2.23716685
86Hyperacusis (HP:0010780)2.23446845
87Precocious puberty (HP:0000826)2.22108507
88Hemiplegia (HP:0002301)2.18476335
89Anal stenosis (HP:0002025)2.15608467
90Megalencephaly (HP:0001355)2.12785786
91Protruding tongue (HP:0010808)2.11531765
92Prostate neoplasm (HP:0100787)2.11481304
93Incomplete penetrance (HP:0003829)2.11329820
94Obstructive sleep apnea (HP:0002870)2.05598714
95Ankyloglossia (HP:0010296)2.03602748
96Morphological abnormality of the pyramidal tract (HP:0002062)2.03510585
97Depressed nasal tip (HP:0000437)2.03169425
98Lower limb muscle weakness (HP:0007340)2.02675522
99Ventricular fibrillation (HP:0001663)2.02405503
100Abnormality of the corticospinal tract (HP:0002492)2.01855723
101Choanal stenosis (HP:0000452)2.00320471
102Degeneration of the lateral corticospinal tracts (HP:0002314)2.00046132
103Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00046132
104Sporadic (HP:0003745)1.99889646
105Limb dystonia (HP:0002451)1.99651385
106Lower limb amyotrophy (HP:0007210)1.99617786
107Blue irides (HP:0000635)1.99558367
108Pointed chin (HP:0000307)1.98844133
109Abnormality of the parathyroid morphology (HP:0011766)1.97472698
110Gait ataxia (HP:0002066)1.96490354
111Abnormality of salivation (HP:0100755)1.91827224
112Azoospermia (HP:0000027)1.91577343
113Shawl scrotum (HP:0000049)1.90202341
114Neoplasm of the adrenal cortex (HP:0100641)1.90181651
115Inappropriate behavior (HP:0000719)1.87755361
116Limb ataxia (HP:0002070)1.87111318
117Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85066258
118Skin pits (HP:0100276)1.84525731
119Abnormality of the astrocytes (HP:0100707)1.83888823
120Astrocytoma (HP:0009592)1.83888823
121Neuronal loss in central nervous system (HP:0002529)1.83693417
122Retinal dysplasia (HP:0007973)1.83289092
123Hepatoblastoma (HP:0002884)1.82643716
124Pheochromocytoma (HP:0002666)1.80620078
125Hyperglycinuria (HP:0003108)1.80297542
126Death in childhood (HP:0003819)1.80061833
127Abnormal EKG (HP:0003115)1.78592777
128Specific learning disability (HP:0001328)1.77509140
129Abnormality of chromosome segregation (HP:0002916)1.76323896
130Macroorchidism (HP:0000053)1.75728500
131Psychosis (HP:0000709)1.74667666
132Abnormality of saccadic eye movements (HP:0000570)1.73910938
133Tented upper lip vermilion (HP:0010804)1.73599320
134Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.72805713
135Insomnia (HP:0100785)1.72182004
136Clonus (HP:0002169)1.71626133
137Delusions (HP:0000746)1.71014791
138Bronchomalacia (HP:0002780)1.70964779
139Aplasia of the musculature (HP:0100854)1.70837586
140Rigidity (HP:0002063)1.70734175
141Intellectual disability, profound (HP:0002187)1.69961947
142Gait imbalance (HP:0002141)1.68510469
143Abnormally folded helix (HP:0008544)1.68412004
144Abnormality of glycine metabolism (HP:0010895)1.68394483
145Abnormality of serine family amino acid metabolism (HP:0010894)1.68394483
146Sleep apnea (HP:0010535)1.68383329
147Lip pit (HP:0100267)1.67916491
148Lower limb asymmetry (HP:0100559)1.67343971
149Rapidly progressive (HP:0003678)1.67286058

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.01229428
2NTRK34.70467755
3CAMK1D3.79296761
4MAP3K93.61492903
5MAP3K43.14863184
6MARK12.96047005
7MAP2K72.73227119
8MINK12.57065810
9TNK22.40888717
10DAPK22.37389329
11MAP3K122.32172006
12CASK2.28275876
13EEF2K2.19052812
14KSR22.16523465
15TAF12.09077626
16NTRK22.06811622
17TRIB32.03777424
18PAK62.01937450
19MAP2K42.00823617
20PRKD31.90349070
21TNIK1.89070759
22KSR11.85471370
23RIPK41.84792541
24CAMKK11.82070302
25NTRK11.76937873
26DAPK11.75406545
27PRKD21.68702514
28CDK51.58891816
29SMG11.49795858
30CDK191.49369525
31FES1.49240921
32ICK1.48786036
33PLK21.47976583
34PNCK1.40357064
35GRK11.34366240
36PRPF4B1.30767532
37ARAF1.26245334
38SIK21.25885221
39MAPK131.23539069
40MAP3K21.20162081
41PRKCG1.19110939
42GRK51.19060043
43MAP3K131.17933833
44CAMKK21.17572769
45PKN21.14579629
46STK381.12440982
47CAMK2A1.07784780
48CAMK10.99985629
49TYRO30.96765052
50TAOK10.96678354
51RAF10.93509247
52CDK180.90319249
53PTK2B0.89494988
54CAMK2B0.89165834
55UHMK10.88257297
56CDK150.86261315
57CDK140.86062216
58STK390.84760772
59SGK2230.83229595
60SGK4940.83229595
61TSSK60.82681354
62MARK20.81373707
63PHKG20.80780384
64PHKG10.80780384
65STK110.80490772
66BMPR20.77548803
67SGK20.77459164
68LATS20.77148797
69OXSR10.76684931
70RET0.76498397
71SGK10.76376990
72PRKCH0.75606178
73CDK11A0.75090126
74SIK10.72582168
75CDK120.69404412
76DYRK1A0.65982841
77ALK0.65699222
78CSNK1A1L0.65557272
79PDK10.65502017
80CSNK1G20.64805777
81PASK0.64286056
82AKT30.63784205
83SGK30.63655348
84PAK30.63415183
85NME10.62891464
86SIK30.61177496
87MAP3K10.59538892
88PDPK10.58631434
89BRSK10.57596850
90MAP3K60.57142553
91MKNK20.56730178
92PDGFRA0.54779703
93PRKCE0.54132227
94IRAK20.52270440
95MTOR0.51325739
96RPS6KA30.48512403
97FGR0.48375798
98PRKCZ0.47213809
99PINK10.46538990
100NEK60.45712156
101MAP2K10.45652091
102CAMK1G0.44653352
103FYN0.44294543
104CAMK40.44056212
105CAMK2D0.43632274
106LMTK20.42924045
107CCNB10.42759843
108BRSK20.42600469
109PAK20.41853973
110CSNK1E0.41317808
111MAP3K110.40950098
112MAP3K70.40851344
113CAMK2G0.39349330
114NEK10.39336212
115WNK30.37656518
116WNK10.37605192
117DAPK30.37472066
118MAPK100.36951149
119FER0.36714945
120CDK70.36099510
121PRKCB0.34788268
122SCYL20.33712297
123BRAF0.33696380
124VRK20.32219778
125AURKA0.32123251
126DMPK0.30364969
127MUSK0.30234793
128BCR0.29128198
129GSK3B0.28165098
130RPS6KA20.28096437
131CSNK1G30.27035523
132PRKCI0.25955061
133PRKDC0.22444321
134PRKAA10.21312946

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.77989252
2Synaptic vesicle cycle_Homo sapiens_hsa047213.35420570
3Olfactory transduction_Homo sapiens_hsa047402.96028954
4Fatty acid biosynthesis_Homo sapiens_hsa000612.78984785
5GABAergic synapse_Homo sapiens_hsa047272.78242977
6Circadian entrainment_Homo sapiens_hsa047132.78055739
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75107121
8Long-term potentiation_Homo sapiens_hsa047202.71263862
9Morphine addiction_Homo sapiens_hsa050322.63453510
10Glutamatergic synapse_Homo sapiens_hsa047242.62938442
11Amphetamine addiction_Homo sapiens_hsa050312.57313316
12Dopaminergic synapse_Homo sapiens_hsa047282.25130893
13Salivary secretion_Homo sapiens_hsa049702.17519868
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04400059
15Cholinergic synapse_Homo sapiens_hsa047252.01330132
16Insulin secretion_Homo sapiens_hsa049111.97902995
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84109628
18Gastric acid secretion_Homo sapiens_hsa049711.83751015
19Vitamin B6 metabolism_Homo sapiens_hsa007501.74801735
20Cocaine addiction_Homo sapiens_hsa050301.74472405
21Renin secretion_Homo sapiens_hsa049241.72179246
22Calcium signaling pathway_Homo sapiens_hsa040201.71313096
23Serotonergic synapse_Homo sapiens_hsa047261.69199097
24Oxytocin signaling pathway_Homo sapiens_hsa049211.68741206
25Taste transduction_Homo sapiens_hsa047421.67850090
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65721346
27Long-term depression_Homo sapiens_hsa047301.63408193
28Collecting duct acid secretion_Homo sapiens_hsa049661.59605310
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58192057
30GnRH signaling pathway_Homo sapiens_hsa049121.41250934
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37660264
32Vitamin digestion and absorption_Homo sapiens_hsa049771.35812080
33Arginine and proline metabolism_Homo sapiens_hsa003301.35259320
34Gap junction_Homo sapiens_hsa045401.32386679
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30911790
36cAMP signaling pathway_Homo sapiens_hsa040241.30292520
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29105632
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24295029
39Glioma_Homo sapiens_hsa052141.17367060
40Fatty acid metabolism_Homo sapiens_hsa012121.14658808
41Type II diabetes mellitus_Homo sapiens_hsa049301.13666215
42Axon guidance_Homo sapiens_hsa043601.12930309
43Histidine metabolism_Homo sapiens_hsa003401.12576928
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10886905
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08551232
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07683839
47Estrogen signaling pathway_Homo sapiens_hsa049151.07451455
48ErbB signaling pathway_Homo sapiens_hsa040121.06928091
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05631530
50Propanoate metabolism_Homo sapiens_hsa006401.04869413
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01998897
52Lysine degradation_Homo sapiens_hsa003100.99550564
53Cardiac muscle contraction_Homo sapiens_hsa042600.99273110
54Vibrio cholerae infection_Homo sapiens_hsa051100.98178094
55Melanogenesis_Homo sapiens_hsa049160.97798421
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97419916
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.92532688
58Mineral absorption_Homo sapiens_hsa049780.90884313
59Nitrogen metabolism_Homo sapiens_hsa009100.90037313
60AMPK signaling pathway_Homo sapiens_hsa041520.87543816
61Phenylalanine metabolism_Homo sapiens_hsa003600.83768373
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81819457
63Phototransduction_Homo sapiens_hsa047440.81418259
64Pyruvate metabolism_Homo sapiens_hsa006200.80791721
65Dorso-ventral axis formation_Homo sapiens_hsa043200.80691394
66Oocyte meiosis_Homo sapiens_hsa041140.80172681
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79764252
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.79051527
69Prostate cancer_Homo sapiens_hsa052150.76452241
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76447633
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76248382
72Pancreatic secretion_Homo sapiens_hsa049720.75814672
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75448997
74Type I diabetes mellitus_Homo sapiens_hsa049400.73372450
75Dilated cardiomyopathy_Homo sapiens_hsa054140.72714191
76Choline metabolism in cancer_Homo sapiens_hsa052310.72344455
77MAPK signaling pathway_Homo sapiens_hsa040100.71541345
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70967445
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70958747
80Thyroid hormone synthesis_Homo sapiens_hsa049180.70224334
81mRNA surveillance pathway_Homo sapiens_hsa030150.69807316
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66704831
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63735866
84Ras signaling pathway_Homo sapiens_hsa040140.62125813
85Rap1 signaling pathway_Homo sapiens_hsa040150.62094414
86Renin-angiotensin system_Homo sapiens_hsa046140.62052532
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.61961952
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59374627
89Melanoma_Homo sapiens_hsa052180.58763061
90Biosynthesis of amino acids_Homo sapiens_hsa012300.58690195
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.57888995
92VEGF signaling pathway_Homo sapiens_hsa043700.56072839
93Alcoholism_Homo sapiens_hsa050340.55415775
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55289748
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54723298
96Basal transcription factors_Homo sapiens_hsa030220.54553010
97Hippo signaling pathway_Homo sapiens_hsa043900.53206820
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52116612
99Glucagon signaling pathway_Homo sapiens_hsa049220.52019470
100Tight junction_Homo sapiens_hsa045300.51346731
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.50554554
102beta-Alanine metabolism_Homo sapiens_hsa004100.50517439
103Colorectal cancer_Homo sapiens_hsa052100.50157623
104Non-small cell lung cancer_Homo sapiens_hsa052230.48315261
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47904864
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46753461
107Alzheimers disease_Homo sapiens_hsa050100.45622678
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45288232
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44937300
110Inositol phosphate metabolism_Homo sapiens_hsa005620.44867980
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44280981
112mTOR signaling pathway_Homo sapiens_hsa041500.44149150
113Bile secretion_Homo sapiens_hsa049760.43633395
114Hedgehog signaling pathway_Homo sapiens_hsa043400.41939326
115Endocytosis_Homo sapiens_hsa041440.39571073
116African trypanosomiasis_Homo sapiens_hsa051430.38847789
117Prion diseases_Homo sapiens_hsa050200.38583779
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37410189
119Wnt signaling pathway_Homo sapiens_hsa043100.37247154
120Butanoate metabolism_Homo sapiens_hsa006500.36635876
121Endometrial cancer_Homo sapiens_hsa052130.36321665
122Renal cell carcinoma_Homo sapiens_hsa052110.35935729
123Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33525948
124Chemokine signaling pathway_Homo sapiens_hsa040620.33069958
125Insulin signaling pathway_Homo sapiens_hsa049100.32005835
126Circadian rhythm_Homo sapiens_hsa047100.31949511
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31574624
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31129560
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30891259
130Ovarian steroidogenesis_Homo sapiens_hsa049130.28622118
131Oxidative phosphorylation_Homo sapiens_hsa001900.23624778
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22480472

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