NEU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1drug transmembrane transport (GO:0006855)6.32576915
2urate metabolic process (GO:0046415)6.03523865
3regulation of cholesterol esterification (GO:0010872)6.00470924
4plasma lipoprotein particle assembly (GO:0034377)5.95142804
5very-low-density lipoprotein particle assembly (GO:0034379)5.79684767
6drug transport (GO:0015893)5.57921770
7protein-lipid complex assembly (GO:0065005)5.44590238
8phospholipid efflux (GO:0033700)5.36594781
9cholesterol efflux (GO:0033344)5.26818088
10cysteine metabolic process (GO:0006534)5.08116210
11glycosphingolipid catabolic process (GO:0046479)5.05445610
12COPI coating of Golgi vesicle (GO:0048205)5.01000545
13Golgi transport vesicle coating (GO:0048200)5.01000545
14lysine catabolic process (GO:0006554)4.97800450
15lysine metabolic process (GO:0006553)4.97800450
16aminoglycoside antibiotic metabolic process (GO:0030647)4.93506233
17* oligosaccharide catabolic process (GO:0009313)4.78997422
18high-density lipoprotein particle remodeling (GO:0034375)4.68790322
19plasma lipoprotein particle clearance (GO:0034381)4.67660350
20glycolipid catabolic process (GO:0019377)4.67428484
21glyoxylate metabolic process (GO:0046487)4.55766836
22phosphate ion transport (GO:0006817)4.51396846
23organic cation transport (GO:0015695)4.33477983
24reverse cholesterol transport (GO:0043691)4.29467347
25L-phenylalanine metabolic process (GO:0006558)4.27167650
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.27167650
27L-phenylalanine catabolic process (GO:0006559)4.23430534
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.23430534
29positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.17352789
30macromolecular complex remodeling (GO:0034367)4.12636772
31plasma lipoprotein particle remodeling (GO:0034369)4.12636772
32protein-lipid complex remodeling (GO:0034368)4.12636772
33ceramide catabolic process (GO:0046514)4.09537972
34drug catabolic process (GO:0042737)4.08318999
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01892903
36tricarboxylic acid metabolic process (GO:0072350)4.01174283
37low-density lipoprotein particle clearance (GO:0034383)4.01117989
38plasma lipoprotein particle organization (GO:0071827)3.99347988
39sulfur amino acid catabolic process (GO:0000098)3.99186662
40peptidyl-glutamic acid carboxylation (GO:0017187)3.91591133
41protein carboxylation (GO:0018214)3.91591133
42response to mercury ion (GO:0046689)3.91389554
43intestinal cholesterol absorption (GO:0030299)3.91069305
44aromatic amino acid family catabolic process (GO:0009074)3.88445277
45phosphate ion transmembrane transport (GO:0035435)3.84796305
46exogenous drug catabolic process (GO:0042738)3.84237651
47protein-lipid complex subunit organization (GO:0071825)3.83640213
48regulation of cytokine secretion involved in immune response (GO:0002739)3.79310104
49short-chain fatty acid metabolic process (GO:0046459)3.78300357
50valine metabolic process (GO:0006573)3.76711914
51cellular modified amino acid catabolic process (GO:0042219)3.75043298
52low-density lipoprotein particle remodeling (GO:0034374)3.73847675
53homocysteine metabolic process (GO:0050667)3.73536246
54sphingolipid catabolic process (GO:0030149)3.70962570
55nonribosomal peptide biosynthetic process (GO:0019184)3.66387288
56quaternary ammonium group transport (GO:0015697)3.62778765
57negative regulation of cholesterol transport (GO:0032375)3.61685733
58negative regulation of sterol transport (GO:0032372)3.61685733
59membrane lipid catabolic process (GO:0046466)3.60242683
60indole-containing compound catabolic process (GO:0042436)3.56741623
61indolalkylamine catabolic process (GO:0046218)3.56741623
62tryptophan catabolic process (GO:0006569)3.56741623
63protein maturation by protein folding (GO:0022417)3.53792361
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.50838793
65glutathione biosynthetic process (GO:0006750)3.49555888
66toxin transport (GO:1901998)3.49437109
67vitamin D metabolic process (GO:0042359)3.48312841
68glycoside metabolic process (GO:0016137)3.44076912
69triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.43942208
70tryptophan metabolic process (GO:0006568)3.42958319
71aspartate family amino acid catabolic process (GO:0009068)3.42330799
72branched-chain amino acid metabolic process (GO:0009081)3.42192275
73sterol transport (GO:0015918)3.39573609
74cholesterol transport (GO:0030301)3.39573609
75protein retention in ER lumen (GO:0006621)3.35748336
76excretion (GO:0007588)3.33410520
77negative regulation of lipase activity (GO:0060192)3.27561127
78positive regulation of triglyceride lipase activity (GO:0061365)3.27541632
79positive regulation of lipoprotein lipase activity (GO:0051006)3.27541632
80fructose metabolic process (GO:0006000)3.27305329
81amino-acid betaine metabolic process (GO:0006577)3.27047329
82modified amino acid transport (GO:0072337)3.26946200
83positive regulation of steroid metabolic process (GO:0045940)3.24700736
84lipoprotein metabolic process (GO:0042157)3.23702272
85renal absorption (GO:0070293)3.23464838
86serine family amino acid catabolic process (GO:0009071)3.23312233
87fatty acid beta-oxidation (GO:0006635)3.20395357
88peptide catabolic process (GO:0043171)3.20138013
892-oxoglutarate metabolic process (GO:0006103)3.17875994
90fatty acid oxidation (GO:0019395)3.17226809
91cellular copper ion homeostasis (GO:0006878)3.14650125
92lipid oxidation (GO:0034440)3.14464056
93amyloid precursor protein catabolic process (GO:0042987)3.13509737
94amino sugar catabolic process (GO:0046348)3.13014340
95alpha-linolenic acid metabolic process (GO:0036109)3.12936366
96kynurenine metabolic process (GO:0070189)3.11470167
97intestinal absorption (GO:0050892)3.09543672
98cholesterol homeostasis (GO:0042632)3.09465980
99sterol homeostasis (GO:0055092)3.08700853
100regulation of cholesterol biosynthetic process (GO:0045540)3.06204652
101regulation of cholesterol homeostasis (GO:2000188)3.05898958
102negative regulation of fibrinolysis (GO:0051918)3.05830523
103serine family amino acid metabolic process (GO:0009069)3.04090327
104negative regulation of fatty acid biosynthetic process (GO:0045717)3.01199850
105aromatic amino acid family metabolic process (GO:0009072)2.99648202
106vitamin transport (GO:0051180)2.97077417
107glutamate metabolic process (GO:0006536)2.96904296
108regulation of heterotypic cell-cell adhesion (GO:0034114)2.96658083
109regulation of extracellular matrix disassembly (GO:0010715)2.96210502
110COPII vesicle coating (GO:0048208)2.90620552
111fatty acid catabolic process (GO:0009062)2.90216010
112regulation of superoxide anion generation (GO:0032928)2.90081162
113regulation of protein activation cascade (GO:2000257)2.88994181
114regulation of cholesterol storage (GO:0010885)2.88837290
115cellular amino acid catabolic process (GO:0009063)2.88317526
116transferrin transport (GO:0033572)2.85890996
117glucose 6-phosphate metabolic process (GO:0051156)2.82855870
118branched-chain amino acid catabolic process (GO:0009083)2.81872004
119retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.80946622
120cellular ketone body metabolic process (GO:0046950)2.80656905
121regulation of fibrinolysis (GO:0051917)2.80326893
1224-hydroxyproline metabolic process (GO:0019471)2.80162016
123glutathione metabolic process (GO:0006749)2.77276932
124response to thyroid hormone (GO:0097066)2.77264756
125carnitine metabolic process (GO:0009437)2.76596681
126peptide biosynthetic process (GO:0043043)2.76419157
127flavonoid metabolic process (GO:0009812)2.75771737
128acetyl-CoA metabolic process (GO:0006084)2.73972478
129L-ascorbic acid metabolic process (GO:0019852)2.73672116
130proline biosynthetic process (GO:0006561)2.73081055
131NADP metabolic process (GO:0006739)2.72763067
132alpha-amino acid catabolic process (GO:1901606)2.72711233
133proline metabolic process (GO:0006560)2.72567811
134fat-soluble vitamin biosynthetic process (GO:0042362)2.72535717
135keratan sulfate catabolic process (GO:0042340)2.72087152
136positive regulation of fatty acid biosynthetic process (GO:0045723)2.71462291
137pentose-phosphate shunt (GO:0006098)2.71210003
138organic acid catabolic process (GO:0016054)2.70709037
139carboxylic acid catabolic process (GO:0046395)2.70709037
140monocarboxylic acid catabolic process (GO:0072329)2.70084104
141macroautophagy (GO:0016236)2.69821939
142sulfur compound transport (GO:0072348)2.69539686
143pinocytosis (GO:0006907)2.69414963
144NADPH regeneration (GO:0006740)2.68902224
145regulation of complement activation (GO:0030449)2.68088913
146cellular zinc ion homeostasis (GO:0006882)2.66846099
147phosphate ion homeostasis (GO:0055062)2.65912578
148trivalent inorganic anion homeostasis (GO:0072506)2.65912578
149negative regulation of protein activation cascade (GO:2000258)2.64697352
150indolalkylamine metabolic process (GO:0006586)2.63904905
151glutathione derivative metabolic process (GO:1901685)2.62967824
152glutathione derivative biosynthetic process (GO:1901687)2.62967824
153glucuronate metabolic process (GO:0019585)2.62073175
154uronic acid metabolic process (GO:0006063)2.62073175
155regulation of metalloenzyme activity (GO:0048552)2.61268627
156trivalent inorganic cation transport (GO:0072512)2.60968872
157ferric iron transport (GO:0015682)2.60968872
158beta-amyloid metabolic process (GO:0050435)2.60579497
159activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60260245
160GDP-mannose metabolic process (GO:0019673)2.60090540
161carnitine transport (GO:0015879)2.58770758
162amino-acid betaine transport (GO:0015838)2.58770758
163lytic vacuole organization (GO:0080171)2.57934519
164lysosome organization (GO:0007040)2.57934519
165cholesterol metabolic process (GO:0008203)2.57258980
166drug metabolic process (GO:0017144)2.57249670
167glutamine family amino acid biosynthetic process (GO:0009084)2.56733905
168bile acid and bile salt transport (GO:0015721)2.56115244
169NADH metabolic process (GO:0006734)2.52414595
170aldehyde catabolic process (GO:0046185)2.52052391
171N-acetylneuraminate metabolic process (GO:0006054)2.51932286
172serine family amino acid biosynthetic process (GO:0009070)2.51724309
173phospholipid homeostasis (GO:0055091)2.51486588
174positive regulation of hormone metabolic process (GO:0032352)2.51372775
175regulation of cholesterol metabolic process (GO:0090181)2.50238490
176benzene-containing compound metabolic process (GO:0042537)2.50132851
177response to growth hormone (GO:0060416)2.49945468
178bile acid biosynthetic process (GO:0006699)2.49658113
179acylglycerol homeostasis (GO:0055090)2.49645933
180triglyceride homeostasis (GO:0070328)2.49645933
181vitamin transmembrane transport (GO:0035461)2.49288405
182cholesterol biosynthetic process (GO:0006695)2.49257950
183negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.48675844
184ketone body metabolic process (GO:1902224)2.48342858
185antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48060457
186antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48060457
187cellular glucuronidation (GO:0052695)2.47169313
188indole-containing compound metabolic process (GO:0042430)2.47026525
189metanephric nephron tubule development (GO:0072234)2.46385976
190L-alpha-amino acid transmembrane transport (GO:1902475)2.46339045
191apoptotic cell clearance (GO:0043277)2.45379160
192positive regulation of cellular amine metabolic process (GO:0033240)2.44307750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.93664673
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.66145317
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.19821751
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.66049883
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.53876600
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.77923826
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.75976587
8ZNF263_19887448_ChIP-Seq_K562_Human2.57726851
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.48260555
10EGR1_23403033_ChIP-Seq_LIVER_Mouse2.36733834
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.34268337
12STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.27045913
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.23948759
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.17778424
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.05329196
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04932474
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.03237364
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.97646592
19TP63_17297297_ChIP-ChIP_HaCaT_Human1.92553621
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.92152056
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91641074
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.90771647
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89943992
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.88949427
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.88150317
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86640002
27* TFEB_21752829_ChIP-Seq_HELA_Human1.85363096
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.83843838
29LXR_22292898_ChIP-Seq_THP-1_Human1.83226075
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82250350
31* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81905031
32CLOCK_20551151_ChIP-Seq_293T_Human1.71956837
33CDX2_20551321_ChIP-Seq_CACO-2_Human1.68303899
34* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68147338
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.63543903
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.63016193
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60705863
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58205611
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.56970106
40MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.55592826
41TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.53414199
42* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52486437
43GATA1_22025678_ChIP-Seq_K562_Human1.49545057
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.48801000
45FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44957903
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43195706
47RACK7_27058665_Chip-Seq_MCF-7_Human1.39197927
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38657606
49GATA4_25053715_ChIP-Seq_YYC3_Human1.37464037
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37196472
51SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31252864
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29918486
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28817462
54SOX2_20726797_ChIP-Seq_SW620_Human1.28255158
55* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.24615307
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21782000
57GATA6_25053715_ChIP-Seq_YYC3_Human1.21767199
58JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.21270822
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21205022
60TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18056050
61VDR_21846776_ChIP-Seq_THP-1_Human1.17363975
62* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16429829
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12294612
64GATA1_19941826_ChIP-Seq_K562_Human1.12057789
65VDR_24763502_ChIP-Seq_THP-1_Human1.11573363
66SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11240760
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09308903
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08946915
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08448491
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08305825
71HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08123168
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07804029
73EGR1_19032775_ChIP-ChIP_M12_Human1.07796315
74* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07492209
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06827230
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.05221595
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04772358
78SPI1_23127762_ChIP-Seq_K562_Human1.04538170
79BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04375366
80PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03711759
81PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03126315
82GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02979536
83MAF_26560356_Chip-Seq_TH1_Human1.01730019
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01674448
85GATA2_19941826_ChIP-Seq_K562_Human1.00883840
86PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00476382
87GATA2_21666600_ChIP-Seq_HMVEC_Human0.99880667
88* HNF4A_19822575_ChIP-Seq_HepG2_Human0.99461284
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.99448687
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99406368
91RUNX1_22412390_ChIP-Seq_EML_Mouse0.99237228
92* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99080074
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.98866148
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.98768133
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98368708
96E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98209987
97CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97802742
98TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97279509
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.97181632
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96531488
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96222683
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96146351
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95392883
104GATA3_24758297_ChIP-Seq_MCF-7_Human0.95338515
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95336190
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95216409
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.95159030
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95054787
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94218896
110STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94180402
111ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94018909
112* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93822776
113GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93822547
114SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.93578820
115EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93367971
116NCOR1_26117541_ChIP-Seq_K562_Human0.92879314
117MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92629137
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92592109
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92003597
120TBX5_21415370_ChIP-Seq_HL-1_Mouse0.91855352
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91136215
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88964443
123RUNX_20019798_ChIP-Seq_JUKART_Human0.88960852
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.88877643
125BCOR_27268052_Chip-Seq_Bcells_Human0.88838793
126VDR_24787735_ChIP-Seq_THP-1_Human0.88816789
127SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88447541
128SRF_21415370_ChIP-Seq_HL-1_Mouse0.88442507
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88266900
130PU_27001747_Chip-Seq_BMDM_Mouse0.87699216
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86561600
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86339973
133TAF2_19829295_ChIP-Seq_ESCs_Human0.86059651
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84185784
135* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83258964
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83240089
137KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82332235
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82312521
139SPI1_23547873_ChIP-Seq_NB4_Human0.82182237
140GATA3_27048872_Chip-Seq_THYMUS_Human0.82059673
141ATF3_27146783_Chip-Seq_COLON_Human0.81820191
142NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80465330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.71177493
2MP0002139_abnormal_hepatobiliary_system4.58823271
3MP0004043_abnormal_pH_regulation3.71062411
4* MP0005058_abnormal_lysosome_morphology3.49977642
5MP0004019_abnormal_vitamin_homeostasis3.36093572
6MP0005332_abnormal_amino_acid3.34374002
7MP0003195_calcinosis3.18584716
8MP0008875_abnormal_xenobiotic_pharmacok3.02828887
9* MP0009643_abnormal_urine_homeostasis2.98928552
10MP0002138_abnormal_hepatobiliary_system2.83703111
11MP0005365_abnormal_bile_salt2.76356995
12MP0002254_reproductive_system_inflammat2.72339845
13MP0001765_abnormal_ion_homeostasis2.66777027
14MP0005085_abnormal_gallbladder_physiolo2.54224687
15MP0009840_abnormal_foam_cell2.54115776
16MP0003191_abnormal_cellular_cholesterol2.48185196
17MP0001756_abnormal_urination2.36073173
18MP0005636_abnormal_mineral_homeostasis2.31202185
19MP0003252_abnormal_bile_duct2.22816145
20MP0002136_abnormal_kidney_physiology2.07384529
21MP0003172_abnormal_lysosome_physiology2.05515166
22MP0003300_gastrointestinal_ulcer2.00871110
23MP0001666_abnormal_nutrient_absorption1.93659754
24MP0010234_abnormal_vibrissa_follicle1.92455568
25MP0005408_hypopigmentation1.85656084
26MP0003878_abnormal_ear_physiology1.79836211
27MP0005377_hearing/vestibular/ear_phenot1.79836211
28MP0004272_abnormal_basement_membrane1.77083692
29MP0010329_abnormal_lipoprotein_level1.64991229
30MP0003123_paternal_imprinting1.63984848
31MP0003183_abnormal_peptide_metabolism1.57122942
32MP0000604_amyloidosis1.54941838
33MP0003806_abnormal_nucleotide_metabolis1.49912518
34MP0003186_abnormal_redox_activity1.48170673
35MP0005319_abnormal_enzyme/_coenzyme1.47622329
36* MP0005584_abnormal_enzyme/coenzyme_acti1.45432183
37MP0002118_abnormal_lipid_homeostasis1.41087705
38MP0002089_abnormal_postnatal_growth/wei1.37939426
39MP0003436_decreased_susceptibility_to1.35611665
40MP0006082_CNS_inflammation1.35393874
41MP0005083_abnormal_biliary_tract1.35256370
42MP0002876_abnormal_thyroid_physiology1.35119990
43MP0003724_increased_susceptibility_to1.34058877
44MP0000609_abnormal_liver_physiology1.33567097
45MP0003329_amyloid_beta_deposits1.33444816
46MP0002877_abnormal_melanocyte_morpholog1.30615871
47MP0005084_abnormal_gallbladder_morpholo1.29854033
48MP0003566_abnormal_cell_adhesion1.27442250
49MP0006054_spinal_hemorrhage1.26541898
50MP0005310_abnormal_salivary_gland1.25946576
51* MP0008469_abnormal_protein_level1.25798048
52MP0005167_abnormal_blood-brain_barrier1.19423920
53MP0004264_abnormal_extraembryonic_tissu1.19190240
54MP0002419_abnormal_innate_immunity1.17486654
55MP0003303_peritoneal_inflammation1.17075787
56MP0003866_abnormal_defecation1.16697903
57MP0000343_altered_response_to1.15893831
58MP0005451_abnormal_body_composition1.14786604
59MP0001958_emphysema1.14073221
60MP0000538_abnormal_urinary_bladder1.13311554
61MP0009764_decreased_sensitivity_to1.12409631
62MP0003122_maternal_imprinting1.11270981
63MP0001845_abnormal_inflammatory_respons1.10652526
64MP0003075_altered_response_to1.10497748
65MP0000371_diluted_coat_color1.08773512
66MP0009785_altered_susceptibility_to1.07231777
67MP0005670_abnormal_white_adipose1.06246544
68MP0003879_abnormal_hair_cell1.05033819
69MP0005164_abnormal_response_to1.03986509
70MP0001764_abnormal_homeostasis1.03809598
71MP0000858_altered_metastatic_potential1.03673567
72MP0003453_abnormal_keratinocyte_physiol1.02015776
73MP0002090_abnormal_vision1.01803181
74MP0001873_stomach_inflammation0.99199556
75MP0001835_abnormal_antigen_presentation0.97883841
76MP0005025_abnormal_response_to0.96810630
77MP0002928_abnormal_bile_duct0.96361128
78* MP0009642_abnormal_blood_homeostasis0.96353141
79MP0001790_abnormal_immune_system0.95805858
80MP0005387_immune_system_phenotype0.95805858
81MP0005535_abnormal_body_temperature0.94763372
82MP0005000_abnormal_immune_tolerance0.94359876
83MP0000230_abnormal_systemic_arterial0.94025984
84MP0010386_abnormal_urinary_bladder0.93214060
85MP0005464_abnormal_platelet_physiology0.92650674
86MP0003690_abnormal_glial_cell0.91056910
87MP0004233_abnormal_muscle_weight0.90958948
88MP0001853_heart_inflammation0.90663338
89MP0000639_abnormal_adrenal_gland0.90122148
90MP0005166_decreased_susceptibility_to0.89492497
91MP0003950_abnormal_plasma_membrane0.88961734
92MP0006036_abnormal_mitochondrial_physio0.87698054
93MP0001663_abnormal_digestive_system0.87397320
94MP0008961_abnormal_basal_metabolism0.85766210
95MP0005379_endocrine/exocrine_gland_phen0.83890980
96MP0010155_abnormal_intestine_physiology0.83417892
97MP0008438_abnormal_cutaneous_collagen0.83300811
98MP0003868_abnormal_feces_composition0.82796062
99MP0003656_abnormal_erythrocyte_physiolo0.82592907
100MP0009780_abnormal_chondrocyte_physiolo0.82037419
101MP0002078_abnormal_glucose_homeostasis0.81267357
102* MP0002135_abnormal_kidney_morphology0.81210333
103MP0005220_abnormal_exocrine_pancreas0.80034860
104MP0005023_abnormal_wound_healing0.79828314
105MP0002998_abnormal_bone_remodeling0.78792329
106MP0002148_abnormal_hypersensitivity_rea0.78334941
107MP0000920_abnormal_myelination0.77876015
108MP0001533_abnormal_skeleton_physiology0.76732731
109MP0004947_skin_inflammation0.75543304
110MP0009333_abnormal_splenocyte_physiolog0.75182451
111MP0005165_increased_susceptibility_to0.75033236
112MP0001661_extended_life_span0.74693443
113MP0005257_abnormal_intraocular_pressure0.74639886
114MP0003638_abnormal_response/metabolism_0.74472840
115* MP0000598_abnormal_liver_morphology0.73475447
116MP0000013_abnormal_adipose_tissue0.72655175
117MP0002693_abnormal_pancreas_physiology0.72441728
118MP0001915_intracranial_hemorrhage0.71802266
119MP0001727_abnormal_embryo_implantation0.71014507
120MP0001944_abnormal_pancreas_morphology0.70033080
121MP0002909_abnormal_adrenal_gland0.69049447
122MP0002723_abnormal_immune_serum0.68943586
123MP0002452_abnormal_antigen_presenting0.68695892
124MP0002168_other_aberrant_phenotype0.67719556
125* MP0003634_abnormal_glial_cell0.66895313
126MP0002295_abnormal_pulmonary_circulatio0.66450023
127MP0005076_abnormal_cell_differentiation0.66322445
128MP0005381_digestive/alimentary_phenotyp0.65448983
129MP0000685_abnormal_immune_system0.64534487
130MP0002896_abnormal_bone_mineralization0.63983071
131MP0008260_abnormal_autophagy0.63134735
132MP0004858_abnormal_nervous_system0.62318471
133MP0003795_abnormal_bone_structure0.61591452
134MP0001664_abnormal_digestion0.61563572
135MP0000003_abnormal_adipose_tissue0.61248730
136MP0000681_abnormal_thyroid_gland0.61145195
137MP0003632_abnormal_nervous_system0.58800241
138MP0001881_abnormal_mammary_gland0.52312466

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)5.22763951
2Hyperactive renin-angiotensin system (HP:0000841)5.22629370
3Gout (HP:0001997)4.96661040
4Increased circulating renin level (HP:0000848)4.93362266
5Hypokalemic alkalosis (HP:0001949)4.90919264
6Abnormality of chloride homeostasis (HP:0011422)4.60494725
7Hypomagnesemia (HP:0002917)4.41477834
8Deep venous thrombosis (HP:0002625)4.22819058
9Abnormality of magnesium homeostasis (HP:0004921)4.12760237
10Polyuria (HP:0000103)4.12635210
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.12015499
12Proximal tubulopathy (HP:0000114)4.08419362
13Abnormal urine output (HP:0012590)4.01751519
14Abnormality of renal excretion (HP:0011036)3.87329614
15Abnormality of purine metabolism (HP:0004352)3.79905052
16Hyperglycinuria (HP:0003108)3.78800900
17Alkalosis (HP:0001948)3.76746090
18Generalized aminoaciduria (HP:0002909)3.73205412
19Hypobetalipoproteinemia (HP:0003563)3.58348692
20Vertebral compression fractures (HP:0002953)3.54095242
21Abnormality of renin-angiotensin system (HP:0000847)3.53804340
22Loss of speech (HP:0002371)3.52801763
23* Vacuolated lymphocytes (HP:0001922)3.48758464
24Increased purine levels (HP:0004368)3.47419327
25Hyperuricemia (HP:0002149)3.47419327
26Abnormality of the common coagulation pathway (HP:0010990)3.44085610
27Ketoacidosis (HP:0001993)3.37971196
28Urinary glycosaminoglycan excretion (HP:0003541)3.37166482
29Mucopolysacchariduria (HP:0008155)3.37166482
30Prolonged neonatal jaundice (HP:0006579)3.33303729
31Hyperaldosteronism (HP:0000859)3.32544629
32Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32317755
33Polydipsia (HP:0001959)3.32030267
34Abnormal drinking behavior (HP:0030082)3.32030267
35* Dysostosis multiplex (HP:0000943)3.29660359
36Tetany (HP:0001281)3.29632999
37Ketosis (HP:0001946)3.23594410
38Neurofibrillary tangles (HP:0002185)3.21831389
39Prolonged partial thromboplastin time (HP:0003645)3.18517256
40Abnormality of polysaccharide metabolism (HP:0011012)3.18126948
41Abnormality of glycosaminoglycan metabolism (HP:0004371)3.18126948
42Abnormality of mucopolysaccharide metabolism (HP:0011020)3.18126948
43Abnormality of serine family amino acid metabolism (HP:0010894)3.09568884
44Abnormality of glycine metabolism (HP:0010895)3.09568884
45Hypokinesia (HP:0002375)3.09487911
46Amyloidosis (HP:0011034)3.08538666
47Hypolipoproteinemia (HP:0010981)3.07737874
48Glomerulonephritis (HP:0000099)3.06866510
49Renal salt wasting (HP:0000127)3.02225075
50Retinal atrophy (HP:0001105)2.98634836
51Xanthomatosis (HP:0000991)2.97807511
52Myocardial infarction (HP:0001658)2.96217690
53Glycosuria (HP:0003076)2.91060717
54Abnormality of urine glucose concentration (HP:0011016)2.91060717
55Abnormality of nucleobase metabolism (HP:0010932)2.90864869
56Abnormality of fatty-acid metabolism (HP:0004359)2.85918710
57Malnutrition (HP:0004395)2.84101981
58Abnormality of proline metabolism (HP:0010907)2.82863798
59Hydroxyprolinuria (HP:0003080)2.82863798
60Nuclear cataract (HP:0100018)2.79204460
61Progressive neurologic deterioration (HP:0002344)2.74821268
62Hypokalemia (HP:0002900)2.72520732
63J-shaped sella turcica (HP:0002680)2.71004506
64Complement deficiency (HP:0004431)2.70966682
65Hypoglycemic coma (HP:0001325)2.62088896
66Abnormality of glycolipid metabolism (HP:0010969)2.62025557
67Abnormality of liposaccharide metabolism (HP:0010968)2.62025557
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.62025557
69Hypophosphatemia (HP:0002148)2.61272210
70Hypoalphalipoproteinemia (HP:0003233)2.56715101
71Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56255395
72Increased cerebral lipofuscin (HP:0011813)2.55354194
73Hyperphosphaturia (HP:0003109)2.52379999
74Hyperammonemia (HP:0001987)2.52349559
75Cerebral inclusion bodies (HP:0100314)2.52142626
76Axonal loss (HP:0003447)2.51633536
77Mitral stenosis (HP:0001718)2.51603164
78Gingival bleeding (HP:0000225)2.51472769
79Spontaneous abortion (HP:0005268)2.50433263
80Vascular calcification (HP:0004934)2.40706529
81Late onset (HP:0003584)2.38887125
82Sensorimotor neuropathy (HP:0007141)2.37131748
83Systemic lupus erythematosus (HP:0002725)2.37030676
84Abnormality of monocarboxylic acid metabolism (HP:0010996)2.36214325
85Hypercholesterolemia (HP:0003124)2.35380406
86Renal tubular acidosis (HP:0001947)2.34389474
87Hyperglycinemia (HP:0002154)2.33638207
88Abnormal urine phosphate concentration (HP:0012599)2.33548722
89Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31724271
90Dicarboxylic aciduria (HP:0003215)2.31724271
91* Cardiomegaly (HP:0001640)2.31505173
92Abnormal enzyme/coenzyme activity (HP:0012379)2.30031151
93Increased serum ferritin (HP:0003281)2.29306787
94* Abnormality of macrophages (HP:0004311)2.27763503
95Purpura (HP:0000979)2.27591274
96Hemorrhage of the eye (HP:0011885)2.27552047
97Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26643409
98Cervical subluxation (HP:0003308)2.24812430
99Tetraparesis (HP:0002273)2.24677530
100Abnormality of alkaline phosphatase activity (HP:0004379)2.24433220
101Abnormality of sulfur amino acid metabolism (HP:0004339)2.24154653
102Fat malabsorption (HP:0002630)2.24148052
103Intrahepatic cholestasis (HP:0001406)2.23990707
104Beaking of vertebral bodies (HP:0004568)2.23273559
105Nephrolithiasis (HP:0000787)2.21539817
106Hypercalciuria (HP:0002150)2.21481705
107Abnormality of potassium homeostasis (HP:0011042)2.20344560
108Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.19353476
109Abnormality of complement system (HP:0005339)2.15914384
110Skin nodule (HP:0200036)2.14998231
111Eczematoid dermatitis (HP:0000976)2.13821799
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.13664154
113Abnormal tarsal ossification (HP:0008369)2.13481490
114Irritability (HP:0000737)2.09571318
115Vomiting (HP:0002013)2.05709447
116Protuberant abdomen (HP:0001538)2.04871510
117Cardiovascular calcification (HP:0011915)2.03863363
118Dehydration (HP:0001944)2.03541073
119Metaphyseal irregularity (HP:0003025)2.03348123
120Rickets (HP:0002748)2.02588279
121Metabolic acidosis (HP:0001942)2.02198203
122Elevated alkaline phosphatase (HP:0003155)2.01096723
123Recurrent gram-negative bacterial infections (HP:0005420)2.00079697
124Recurrent abscess formation (HP:0002722)1.98951774
125Supranuclear gaze palsy (HP:0000605)1.97034422
126Paraparesis (HP:0002385)1.95991967
127Abnormality of carpal bone ossification (HP:0006257)1.95897923
128Pancreatitis (HP:0001733)1.95800355
129Recurrent bacterial skin infections (HP:0005406)1.95389884
130Abdominal distention (HP:0003270)1.94387966
131Nausea (HP:0002018)1.94315045
132Steatorrhea (HP:0002570)1.93814031
133Delayed CNS myelination (HP:0002188)1.93059863
134Hyperlipoproteinemia (HP:0010980)1.92242210
135Ovoid vertebral bodies (HP:0003300)1.91727837
136Cholecystitis (HP:0001082)1.91318723
137Abnormal gallbladder physiology (HP:0012438)1.91318723
138Epidermoid cyst (HP:0200040)1.91007772
139Lethargy (HP:0001254)1.90606110
140Joint hemorrhage (HP:0005261)1.86287450
141Bone pain (HP:0002653)1.85648714
142Flat acetabular roof (HP:0003180)1.84657635
143Pathologic fracture (HP:0002756)1.82399382
144Abnormality of the lumbar spine (HP:0100712)1.80864285
145Abnormality of iron homeostasis (HP:0011031)1.79343060
146Abnormality of the Achilles tendon (HP:0005109)1.79073194
147Abnormality of transition element cation homeostasis (HP:0011030)1.79014739
148Adrenal overactivity (HP:0002717)1.78649532
149Nephrocalcinosis (HP:0000121)1.78061161
150Petechiae (HP:0000967)1.77959946
151Confusion (HP:0001289)1.74168252
152Abnormality of sodium homeostasis (HP:0010931)1.73123567
153Abnormality of pyrimidine metabolism (HP:0004353)1.68087128
154Apathy (HP:0000741)1.68062403
155Interstitial pulmonary disease (HP:0006530)1.66223051
156Increased CSF protein (HP:0002922)1.65327617
157Disinhibition (HP:0000734)1.64999768
158Diminished motivation (HP:0000745)1.64778897
159Opisthotonus (HP:0002179)1.64078876
160Joint swelling (HP:0001386)1.63534232
161Neuronal loss in central nervous system (HP:0002529)1.62093810
162Flared iliac wings (HP:0002869)1.58867054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK45.17559918
2WNK34.20212815
3OXSR13.85650113
4MST1R3.49672120
5BCKDK3.26296472
6ERN13.13637764
7TAOK32.85067333
8IRAK32.36442087
9TRIB32.18393007
10MAP3K21.94775216
11STK391.87533964
12ICK1.86600869
13MAP2K21.85666011
14PIM21.79492055
15RIPK41.76693991
16FGFR31.76523048
17GRK61.75834106
18KSR21.74128037
19TAOK21.71509958
20EPHA21.69779357
21EPHB11.69489284
22MAP4K11.65884625
23FRK1.59755810
24MAPKAPK31.55528170
25MST41.53920667
26PBK1.53228132
27FGFR41.50897250
28MAP3K131.49327949
29BLK1.47901602
30TBK11.44523861
31INSRR1.42476333
32CAMKK21.39169918
33DDR21.36209653
34CDK121.35084951
35LMTK21.32996243
36MAP3K11.30204931
37LATS21.28455883
38TYK21.26265787
39MAP2K61.26247465
40PTK61.24726520
41MAP3K141.22731354
42EEF2K1.22562171
43MET1.18604293
44ARAF1.16952375
45TGFBR21.12070860
46IRAK41.11346013
47LRRK21.11173755
48PKN21.10700772
49TAOK11.05658102
50ACVR1B1.04887690
51MAPK151.03274780
52KDR0.96698917
53ZAP700.96653391
54JAK20.95453771
55PDPK10.94047645
56JAK10.92087730
57PTK20.91625449
58IKBKB0.90522145
59PIK3CA0.90135638
60CSK0.86621042
61WNK10.86510644
62SCYL20.85456782
63FER0.84405594
64LIMK10.84042410
65SIK10.80971882
66SGK4940.80189347
67SGK2230.80189347
68CHUK0.79271541
69MATK0.78389972
70RIPK10.73840925
71PDGFRA0.72066177
72MYLK0.71150514
73PAK40.69352326
74TRPM70.69127388
75ABL20.68853253
76GRK10.68502371
77CDC42BPA0.67256652
78PIK3CG0.66852273
79ADRBK20.66842596
80IRAK20.66753212
81MAP2K10.65728145
82PDK10.65609268
83FES0.65319315
84IKBKE0.65288841
85STK380.64061381
86BTK0.63774096
87PRKAA20.59849221
88MAPK110.59483007
89BRAF0.57188041
90GRK70.56905619
91PRKG20.56600406
92CLK10.56361029
93MAP3K120.56347183
94KIT0.56323362
95MAP3K80.55939452
96IRAK10.55813162
97FLT30.55272801
98MTOR0.54000264
99MAP2K30.53697849
100SYK0.53626306
101MAP3K50.53531132
102STK100.53355394
103MAPKAPK50.52137636
104ITK0.51240805
105EIF2AK10.50762595
106GSK3A0.50554030
107PDK20.49870035
108MAP3K30.49627773
109PRKCI0.49378097
110MUSK0.49340117
111JAK30.49150718
112TIE10.48140678
113MAP3K100.47770127
114MAP3K110.47569010
115STK160.46922271
116NTRK10.45397989
117NME20.44680857
118RET0.44526847
119AKT30.44058562
120CAMKK10.43690689
121SGK30.42902981
122CSF1R0.42728305
123DAPK30.42441334
124PRKCD0.42353294
125MARK30.42114039
126MAPKAPK20.41721797
127LYN0.40479328
128EIF2AK30.38246711
129AKT20.37368478
130FGR0.37235468
131HCK0.36236163
132TESK10.35884914
133DYRK1B0.35829381
134MAP3K70.35662995
135CAMK2D0.35401319
136NME10.34931487
137BMX0.34530075
138NEK90.33291681
139TESK20.33256747
140MAP3K90.32597275
141LCK0.32425250
142CAMK1D0.31589803
143CAMK2G0.31143903
144CSNK1G30.30264584
145PRKD20.28682853
146RPS6KA20.26933260
147PRPF4B0.26622253

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.93930124
2Pentose and glucuronate interconversions_Homo sapiens_hsa000402.62992500
3Butanoate metabolism_Homo sapiens_hsa006502.51746330
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50687308
5Sulfur metabolism_Homo sapiens_hsa009202.49921073
6Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37005235
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29806475
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.22291677
9Tryptophan metabolism_Homo sapiens_hsa003802.07707451
10Fatty acid degradation_Homo sapiens_hsa000712.05238768
11Peroxisome_Homo sapiens_hsa041462.04189952
12* Lysosome_Homo sapiens_hsa041422.03693904
13Collecting duct acid secretion_Homo sapiens_hsa049662.01461659
14Propanoate metabolism_Homo sapiens_hsa006402.00002291
15* Other glycan degradation_Homo sapiens_hsa005111.94508150
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.93781310
17Bile secretion_Homo sapiens_hsa049761.85683789
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79690502
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.79453245
20Vitamin digestion and absorption_Homo sapiens_hsa049771.77524653
21Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.76395633
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69780468
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.65804862
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62238205
25Nitrogen metabolism_Homo sapiens_hsa009101.56073082
26Histidine metabolism_Homo sapiens_hsa003401.55957797
27beta-Alanine metabolism_Homo sapiens_hsa004101.53162733
28Mineral absorption_Homo sapiens_hsa049781.50433153
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48391500
30Pyruvate metabolism_Homo sapiens_hsa006201.48338837
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42564196
32Arginine biosynthesis_Homo sapiens_hsa002201.41178155
33PPAR signaling pathway_Homo sapiens_hsa033201.37009515
34Fatty acid metabolism_Homo sapiens_hsa012121.31384336
35Folate biosynthesis_Homo sapiens_hsa007901.30830028
36Starch and sucrose metabolism_Homo sapiens_hsa005001.27563752
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21650207
38Carbon metabolism_Homo sapiens_hsa012001.19878737
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19218608
40Glutathione metabolism_Homo sapiens_hsa004801.17239011
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16321811
42Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11152785
43Staphylococcus aureus infection_Homo sapiens_hsa051501.09827629
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04756200
45Vibrio cholerae infection_Homo sapiens_hsa051101.04363465
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04301169
47Arginine and proline metabolism_Homo sapiens_hsa003301.03324266
48Glycerolipid metabolism_Homo sapiens_hsa005611.03273234
49Fructose and mannose metabolism_Homo sapiens_hsa000511.02040423
50ABC transporters_Homo sapiens_hsa020101.00726569
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97972312
52Prion diseases_Homo sapiens_hsa050200.97494728
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95884588
54Pentose phosphate pathway_Homo sapiens_hsa000300.93450160
55Renin-angiotensin system_Homo sapiens_hsa046140.88306506
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88276881
57Selenocompound metabolism_Homo sapiens_hsa004500.87416028
58Legionellosis_Homo sapiens_hsa051340.87004653
59Pertussis_Homo sapiens_hsa051330.85018975
60Complement and coagulation cascades_Homo sapiens_hsa046100.83535099
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83407992
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83165242
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79856473
64Vitamin B6 metabolism_Homo sapiens_hsa007500.78272303
65Phenylalanine metabolism_Homo sapiens_hsa003600.76586261
66Bladder cancer_Homo sapiens_hsa052190.74693210
67Galactose metabolism_Homo sapiens_hsa000520.74174643
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.72183471
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67878931
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66675394
71Fat digestion and absorption_Homo sapiens_hsa049750.66330172
72Caffeine metabolism_Homo sapiens_hsa002320.66219052
73Chemical carcinogenesis_Homo sapiens_hsa052040.65720967
74Salmonella infection_Homo sapiens_hsa051320.65431853
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64724692
76Fatty acid biosynthesis_Homo sapiens_hsa000610.64510023
77Thyroid hormone synthesis_Homo sapiens_hsa049180.63619979
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.62561966
79Rheumatoid arthritis_Homo sapiens_hsa053230.62067112
80Protein digestion and absorption_Homo sapiens_hsa049740.62033910
81Biosynthesis of amino acids_Homo sapiens_hsa012300.61417653
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58721953
83TNF signaling pathway_Homo sapiens_hsa046680.58468857
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58130438
85Sulfur relay system_Homo sapiens_hsa041220.55364964
86Fatty acid elongation_Homo sapiens_hsa000620.54902672
87Lysine degradation_Homo sapiens_hsa003100.53338321
88Tyrosine metabolism_Homo sapiens_hsa003500.53136547
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53089705
90Tuberculosis_Homo sapiens_hsa051520.48706839
91Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47154967
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.46976245
93Phagosome_Homo sapiens_hsa041450.44821401
94Leishmaniasis_Homo sapiens_hsa051400.44170556
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42937148
96Metabolic pathways_Homo sapiens_hsa011000.42127153
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.42049119
98* Sphingolipid metabolism_Homo sapiens_hsa006000.39159480
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38724085
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37926419
101Oxidative phosphorylation_Homo sapiens_hsa001900.37702284
102Protein export_Homo sapiens_hsa030600.35688165
103Retinol metabolism_Homo sapiens_hsa008300.35625332
104Osteoclast differentiation_Homo sapiens_hsa043800.35138374
105Proteasome_Homo sapiens_hsa030500.34945367
106Synaptic vesicle cycle_Homo sapiens_hsa047210.33585393
107N-Glycan biosynthesis_Homo sapiens_hsa005100.33232294
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.32444514
109Steroid biosynthesis_Homo sapiens_hsa001000.32050383
110Hepatitis C_Homo sapiens_hsa051600.31467800
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.31317141
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.30982268
113Insulin resistance_Homo sapiens_hsa049310.30515330
114Regulation of autophagy_Homo sapiens_hsa041400.30257124
115Pancreatic secretion_Homo sapiens_hsa049720.29926200
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.29665305
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.28797610
118Arachidonic acid metabolism_Homo sapiens_hsa005900.27989654
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.27716214
120HIF-1 signaling pathway_Homo sapiens_hsa040660.27703046
121Toxoplasmosis_Homo sapiens_hsa051450.26004504
122SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25257977

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