NEURL1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.66316539
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.63592323
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.48615615
4locomotory exploration behavior (GO:0035641)5.46124330
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.45881801
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.41227747
7synaptic vesicle maturation (GO:0016188)5.03442886
8regulation of glutamate receptor signaling pathway (GO:1900449)4.99723327
9synaptic vesicle exocytosis (GO:0016079)4.70507824
10glutamate secretion (GO:0014047)4.69774648
11regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.60529674
12neurotransmitter-gated ion channel clustering (GO:0072578)4.56666284
13protein localization to synapse (GO:0035418)4.52511956
14NADH metabolic process (GO:0006734)4.44512849
15regulation of synaptic vesicle exocytosis (GO:2000300)4.38606345
16neuron cell-cell adhesion (GO:0007158)4.22228088
17regulation of synapse structural plasticity (GO:0051823)4.14402411
18desmosome organization (GO:0002934)4.11212919
19dendritic spine morphogenesis (GO:0060997)4.08581624
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.08012709
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.05343230
22exploration behavior (GO:0035640)4.03938457
23glucocorticoid biosynthetic process (GO:0006704)4.02893867
24postsynaptic membrane organization (GO:0001941)3.99621859
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.96134854
26regulation of synaptic vesicle transport (GO:1902803)3.90207793
27regulation of neuronal synaptic plasticity (GO:0048168)3.89670452
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.89127619
29layer formation in cerebral cortex (GO:0021819)3.81888190
30cGMP-mediated signaling (GO:0019934)3.77337501
31synaptic transmission, glutamatergic (GO:0035249)3.70839884
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67822256
33presynaptic membrane assembly (GO:0097105)3.65053167
34positive regulation of membrane potential (GO:0045838)3.63672571
35cardiac myofibril assembly (GO:0055003)3.61555867
36bundle of His cell to Purkinje myocyte communication (GO:0086069)3.60806590
37neurotransmitter secretion (GO:0007269)3.58619776
38positive regulation of neurotransmitter secretion (GO:0001956)3.56172854
39actin-myosin filament sliding (GO:0033275)3.55649162
40muscle filament sliding (GO:0030049)3.55649162
41regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.53855626
42glutamate receptor signaling pathway (GO:0007215)3.51571308
43negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47588651
44myofibril assembly (GO:0030239)3.47207669
45glomerular filtration (GO:0003094)3.43467889
46regulation of postsynaptic membrane potential (GO:0060078)3.42131586
47neuron-neuron synaptic transmission (GO:0007270)3.38713851
48long-term memory (GO:0007616)3.31574878
49proline transport (GO:0015824)3.31113321
50renal filtration (GO:0097205)3.29766179
51G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27560131
52sarcomere organization (GO:0045214)3.26231265
53auditory behavior (GO:0031223)3.22745663
54cellular response to epinephrine stimulus (GO:0071872)3.22068982
55regulation of dendritic spine morphogenesis (GO:0061001)3.21788294
56angiotensin maturation (GO:0002003)3.21667180
57actin-mediated cell contraction (GO:0070252)3.21618317
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20983784
59regulation of synaptic plasticity (GO:0048167)3.20049341
60regulation of neurotransmitter secretion (GO:0046928)3.19875973
61cytoskeletal anchoring at plasma membrane (GO:0007016)3.17734112
62presynaptic membrane organization (GO:0097090)3.16219610
63positive regulation of neurotransmitter transport (GO:0051590)3.15471570
64long-term synaptic potentiation (GO:0060291)3.13579105
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.13529818
66positive regulation of synapse maturation (GO:0090129)3.12111022
67cardiac muscle contraction (GO:0060048)3.11271425
68mechanosensory behavior (GO:0007638)3.09243640
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09225356
70cell communication involved in cardiac conduction (GO:0086065)3.08061575
71glucocorticoid metabolic process (GO:0008211)3.06833392
72startle response (GO:0001964)3.05554206
73neuron recognition (GO:0008038)3.04566397
74regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.03597000
75epithelial cell-cell adhesion (GO:0090136)3.01655508
76activation of protein kinase A activity (GO:0034199)3.00120512
77neuronal action potential propagation (GO:0019227)2.99255965
78regulation of dendritic spine development (GO:0060998)2.98892849
79axonal fasciculation (GO:0007413)2.98364885
80actomyosin structure organization (GO:0031032)2.98140445
81dendritic spine organization (GO:0097061)2.97488977
82chemosensory behavior (GO:0007635)2.96112782
83response to auditory stimulus (GO:0010996)2.95815235
84ventricular cardiac muscle cell action potential (GO:0086005)2.94010183
85dendrite morphogenesis (GO:0048813)2.92320064
86synaptic vesicle endocytosis (GO:0048488)2.92043007
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.90707653
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89870394
89positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.88758257
90actin filament depolymerization (GO:0030042)2.87851698
91membrane depolarization (GO:0051899)2.87277430
92central nervous system projection neuron axonogenesis (GO:0021952)2.86951311
93response to histamine (GO:0034776)2.84047406
94regulation of synapse maturation (GO:0090128)2.83212549
95carnitine shuttle (GO:0006853)2.83081032
96regulation of neurotransmitter transport (GO:0051588)2.81627683
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80965800
98renal system process involved in regulation of blood volume (GO:0001977)2.80857692
99regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.79686664
100cochlea development (GO:0090102)2.79148878
101actin filament-based movement (GO:0030048)2.78525472
102negative regulation of dendrite development (GO:2000171)2.78381005
103neurotransmitter transport (GO:0006836)2.78305495
104regulation of cardioblast differentiation (GO:0051890)2.77555705
105synapse assembly (GO:0007416)2.76734608
106learning (GO:0007612)2.76591594
107regulation of voltage-gated calcium channel activity (GO:1901385)2.76295102
108membrane hyperpolarization (GO:0060081)2.75378170
109response to epinephrine (GO:0071871)2.75224481
110cardiac conduction (GO:0061337)2.74382636
111regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.73756423
112transmission of nerve impulse (GO:0019226)2.72678557
113behavioral fear response (GO:0001662)2.72348947
114behavioral defense response (GO:0002209)2.72348947
115striated muscle contraction (GO:0006941)2.72343506
116regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.72164299
117endocrine process (GO:0050886)2.72164299
118regulation of systemic arterial blood pressure by hormone (GO:0001990)2.72164299
119cardiac muscle hypertrophy (GO:0003300)2.71895515
120positive regulation of synaptic transmission (GO:0050806)2.70601465
121positive regulation of fatty acid beta-oxidation (GO:0032000)2.70383680
122adherens junction assembly (GO:0034333)2.70190729
123regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69862599
124cerebral cortex radially oriented cell migration (GO:0021799)2.69781709
125barbed-end actin filament capping (GO:0051016)2.69229146
126regulation of synaptic transmission, GABAergic (GO:0032228)2.69107424
127innervation (GO:0060384)2.68341835
128cell communication by electrical coupling (GO:0010644)2.68305055
129histamine secretion (GO:0001821)2.67762552
130establishment of nucleus localization (GO:0040023)2.66509681
131membrane depolarization during action potential (GO:0086010)2.66399043
132ethanol oxidation (GO:0006069)2.64748524
133multicellular organismal signaling (GO:0035637)2.64464508
134regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.64396245
135regulation of vesicle fusion (GO:0031338)2.62966234
136cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.62292474
137negative regulation of fatty acid transport (GO:2000192)2.61156062
138cellular response to catecholamine stimulus (GO:0071870)2.60577702
139cellular response to monoamine stimulus (GO:0071868)2.60577702
140cAMP catabolic process (GO:0006198)2.60230335
141dendrite development (GO:0016358)2.59837144
142visual learning (GO:0008542)2.58586395
143focal adhesion assembly (GO:0048041)2.58218618
144cell-substrate adherens junction assembly (GO:0007045)2.58218618
145cerebellar granule cell differentiation (GO:0021707)2.57988292
146neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.57888442
147positive regulation of cardiac muscle cell differentiation (GO:2000727)2.57080928
148gamma-aminobutyric acid signaling pathway (GO:0007214)2.56676963
149clathrin coat assembly (GO:0048268)2.56420064
150epoxygenase P450 pathway (GO:0019373)2.56322142
151regulation of synaptic transmission (GO:0050804)2.55670638
152striated muscle hypertrophy (GO:0014897)2.55629180
153negative regulation of myotube differentiation (GO:0010832)2.53485273
154receptor guanylyl cyclase signaling pathway (GO:0007168)2.52500029
155regulation of fatty acid beta-oxidation (GO:0031998)2.50903536
156carnitine transmembrane transport (GO:1902603)2.49794466
157amino-acid betaine transport (GO:0015838)2.49221362
158carnitine transport (GO:0015879)2.49221362
159regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.49037972
160creatine metabolic process (GO:0006600)2.48625941
161regulation of fatty acid oxidation (GO:0046320)2.48576748
162phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.48556633
163cell-substrate junction assembly (GO:0007044)2.47868703
164vascular endothelial growth factor signaling pathway (GO:0038084)2.46358539
165ethanol metabolic process (GO:0006067)2.45655250
166regulation of skeletal muscle contraction (GO:0014819)2.45092655
167multicellular organismal water homeostasis (GO:0050891)2.44899733
168skeletal muscle contraction (GO:0003009)2.44868342
169regulation of guanylate cyclase activity (GO:0031282)2.42755096
170fatty acid transmembrane transport (GO:1902001)2.42557300
171renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.42062340
172cardiac muscle hypertrophy in response to stress (GO:0014898)2.40995920
173muscle hypertrophy in response to stress (GO:0003299)2.40995920
174cardiac muscle adaptation (GO:0014887)2.40995920
175atrioventricular valve morphogenesis (GO:0003181)2.40577994
176adhesion of symbiont to host (GO:0044406)2.39752232
177regulation of actin filament-based movement (GO:1903115)2.39242912
178actin filament capping (GO:0051693)2.38494569
179regulation of glucose import in response to insulin stimulus (GO:2001273)2.37996608
180planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36679250
181striated muscle atrophy (GO:0014891)2.36182057
182regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.35906276
183response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.35902083
184gap junction assembly (GO:0016264)2.35440002
185skeletal muscle adaptation (GO:0043501)2.34791861
186regulation of systemic arterial blood pressure (GO:0003073)2.34684963
187regulation of the force of heart contraction (GO:0002026)2.34487897
188regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.33931679
189negative regulation of catenin import into nucleus (GO:0035414)2.32992805
190striated muscle adaptation (GO:0014888)2.32360113
191positive regulation of fatty acid oxidation (GO:0046321)2.31262087
192sarcoplasmic reticulum calcium ion transport (GO:0070296)2.30736837
193urea cycle (GO:0000050)2.30044024
194regulation of cGMP biosynthetic process (GO:0030826)2.29660682
195negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.29224138
196cGMP biosynthetic process (GO:0006182)2.29100507
197regulation of transforming growth factor beta2 production (GO:0032909)2.28859334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.75906986
2GBX2_23144817_ChIP-Seq_PC3_Human3.94702175
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.96112964
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94378140
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92738525
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80730857
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.71313465
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.54729257
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51842272
10RARG_19884340_ChIP-ChIP_MEFs_Mouse2.50630538
11DROSHA_22980978_ChIP-Seq_HELA_Human2.47719132
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47356208
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47356208
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46678718
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45633754
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.43647363
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39404507
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.34286459
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31054525
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26629466
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.23982498
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.16678036
23CDX2_20551321_ChIP-Seq_CACO-2_Human2.16614139
24REST_21632747_ChIP-Seq_MESCs_Mouse2.13421808
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.12325810
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.10362997
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10114784
28ESR1_21235772_ChIP-Seq_MCF-7_Human2.09399247
29ESR1_20079471_ChIP-ChIP_T-47D_Human2.07810848
30* EZH2_27294783_Chip-Seq_ESCs_Mouse2.04507640
31AR_21572438_ChIP-Seq_LNCaP_Human2.03162271
32CLOCK_20551151_ChIP-Seq_293T_Human2.00187056
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93022196
34RARB_27405468_Chip-Seq_BRAIN_Mouse1.90498064
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.87623443
36LXR_22292898_ChIP-Seq_THP-1_Human1.82326919
37RACK7_27058665_Chip-Seq_MCF-7_Human1.80498054
38ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76474928
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76290981
40* TBX20_22328084_ChIP-Seq_HEART_Mouse1.75030352
41* TBX20_22080862_ChIP-Seq_HEART_Mouse1.75030352
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73283553
43SMAD4_21799915_ChIP-Seq_A2780_Human1.72461101
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.69062537
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67905598
46FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.64460408
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.63383739
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61359333
49* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60068442
50TAF15_26573619_Chip-Seq_HEK293_Human1.59269861
51KDM2B_26808549_Chip-Seq_K562_Human1.58303718
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.57164869
53ZNF263_19887448_ChIP-Seq_K562_Human1.56383887
54P300_19829295_ChIP-Seq_ESCs_Human1.56122574
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56098210
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55514707
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.55361634
58EP300_21415370_ChIP-Seq_HL-1_Mouse1.55274262
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54589822
60SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53830457
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.53170832
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.51981481
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.51129860
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50555294
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.50503049
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50483227
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49936790
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46368055
69SOX9_24532713_ChIP-Seq_HFSC_Mouse1.45961606
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45828930
71ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45765192
72MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45433536
73NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45048479
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42755697
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42654481
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41053348
77RXR_22158963_ChIP-Seq_LIVER_Mouse1.40268883
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39872939
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38901849
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.38022115
81CTCF_27219007_Chip-Seq_Bcells_Human1.37726398
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.37040940
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36634421
84CBX2_27304074_Chip-Seq_ESCs_Mouse1.35984153
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35290167
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32024557
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.31970743
88AR_25329375_ChIP-Seq_VCAP_Human1.31886023
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30972237
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.30813315
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30754204
92PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29532841
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27418809
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26853491
95STAT3_23295773_ChIP-Seq_U87_Human1.26188024
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24825758
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24403431
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.24298454
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24137673
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.23545128
101AHR_22903824_ChIP-Seq_MCF-7_Human1.22267303
102IGF1R_20145208_ChIP-Seq_DFB_Human1.21693004
103RING1B_27294783_Chip-Seq_ESCs_Mouse1.21341305
104* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20758753
105FOXO3_23340844_ChIP-Seq_DLD1_Human1.20536435
106RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20479673
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19731108
108TCF4_23295773_ChIP-Seq_U87_Human1.17784518
109* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17225315
110FUS_26573619_Chip-Seq_HEK293_Human1.16796980
111GATA1_22025678_ChIP-Seq_K562_Human1.16540053
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16065647
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16063750
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15371072
115* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15348002
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15338999
117TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15265601
118BP1_19119308_ChIP-ChIP_Hs578T_Human1.15245888
119BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15194078
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14632974
121DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14123983
122RXR_22108803_ChIP-Seq_LS180_Human1.13788627
123CREB1_26743006_Chip-Seq_LNCaP_Human1.13533988
124RNF2_27304074_Chip-Seq_NSC_Mouse1.12447051
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.10712373
126NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10318258
127AR_19668381_ChIP-Seq_PC3_Human1.09803462
128NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09293330
129TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09245595
130POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09245595
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.09169071
132KDM2B_26808549_Chip-Seq_DND41_Human1.08294878
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08172225
134TCF7_22412390_ChIP-Seq_EML_Mouse1.07468464
135TP53_16413492_ChIP-PET_HCT116_Human1.06612628
136* SMC4_20622854_ChIP-Seq_HELA_Human1.05964356
137P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05932442
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.05692415
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05674283
140NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05573310
141PRDM14_20953172_ChIP-Seq_ESCs_Human1.05506482
142TP53_18474530_ChIP-ChIP_U2OS_Human1.04075904
143P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04068902
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03480250
145RING1B_27294783_Chip-Seq_NPCs_Mouse1.03315219
146KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03188219
147SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02791549
148TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01873046
149ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.01593582
150SOX2_20726797_ChIP-Seq_SW620_Human1.01197821
151ISL1_27105846_Chip-Seq_CPCs_Mouse1.00619312
152FOXA2_19822575_ChIP-Seq_HepG2_Human1.00465735
153TCF4_18268006_ChIP-ChIP_LS174T_Human0.99660765
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.99591597
155TP63_22573176_ChIP-Seq_HFKS_Human0.99140925
156KLF5_25053715_ChIP-Seq_YYC3_Human0.99135296
157* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98809258
158RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.98326238
159RUNX2_22187159_ChIP-Seq_PCA_Human0.98033412
160P53_22387025_ChIP-Seq_ESCs_Mouse0.96917626
161ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96909518
162* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96797235
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96715432
164TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96510543
165GATA6_25053715_ChIP-Seq_YYC3_Human0.95970127
166* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95786340
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95559477
168EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94230375
169TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93563158
170CMYC_18555785_Chip-Seq_ESCs_Mouse0.92432892
171MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92378407
172CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90912757
173KDM2B_26808549_Chip-Seq_REH_Human0.90818398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.76657592
2MP0003635_abnormal_synaptic_transmissio3.95038059
3MP0003880_abnormal_central_pattern3.69117544
4MP0004270_analgesia3.47348937
5MP0003705_abnormal_hypodermis_morpholog3.41595290
6MP0002063_abnormal_learning/memory/cond3.31672928
7MP0009745_abnormal_behavioral_response3.24386903
8MP0001968_abnormal_touch/_nociception2.85743651
9MP0009379_abnormal_foot_pigmentation2.77417478
10MP0002822_catalepsy2.75102532
11MP0002572_abnormal_emotion/affect_behav2.75003738
12MP0005360_urolithiasis2.74359719
13MP0009780_abnormal_chondrocyte_physiolo2.73853006
14MP0002064_seizures2.72668037
15MP0005275_abnormal_skin_tensile2.72449401
16MP0005670_abnormal_white_adipose2.72273434
17MP0001486_abnormal_startle_reflex2.63501862
18MP0009046_muscle_twitch2.52414115
19MP0002734_abnormal_mechanical_nocicepti2.39611269
20MP0002736_abnormal_nociception_after2.29312732
21MP0010368_abnormal_lymphatic_system2.22541868
22MP0005423_abnormal_somatic_nervous2.20263670
23MP0006138_congestive_heart_failure2.20085581
24MP0008438_abnormal_cutaneous_collagen2.18862541
25MP0001188_hyperpigmentation2.16331543
26MP0003879_abnormal_hair_cell2.14545936
27MP0000462_abnormal_digestive_system2.06780484
28MP0010234_abnormal_vibrissa_follicle2.06636573
29MP0002272_abnormal_nervous_system2.03192608
30MP0002735_abnormal_chemical_nociception1.97896641
31MP0004264_abnormal_extraembryonic_tissu1.97546142
32MP0000749_muscle_degeneration1.96803904
33MP0001501_abnormal_sleep_pattern1.94904121
34MP0005666_abnormal_adipose_tissue1.94559107
35MP0002796_impaired_skin_barrier1.93179710
36MP0005646_abnormal_pituitary_gland1.91067696
37MP0000569_abnormal_digit_pigmentation1.90626444
38MP0001440_abnormal_grooming_behavior1.89765154
39MP0003787_abnormal_imprinting1.89111393
40MP0002557_abnormal_social/conspecific_i1.87813479
41MP0005330_cardiomyopathy1.83638772
42MP0004811_abnormal_neuron_physiology1.83163686
43MP0004272_abnormal_basement_membrane1.82766011
44MP0004087_abnormal_muscle_fiber1.81458143
45MP0004145_abnormal_muscle_electrophysio1.80996832
46MP0002067_abnormal_sensory_capabilities1.78276120
47MP0008569_lethality_at_weaning1.69387305
48MP0000778_abnormal_nervous_system1.66286071
49MP0005503_abnormal_tendon_morphology1.64512981
50MP0010352_gastrointestinal_tract_polyps1.62373214
51MP0005386_behavior/neurological_phenoty1.60894656
52MP0004924_abnormal_behavior1.60894656
53MP0005645_abnormal_hypothalamus_physiol1.60540338
54MP0000013_abnormal_adipose_tissue1.59038300
55MP0002108_abnormal_muscle_morphology1.58595429
56MP0001970_abnormal_pain_threshold1.55054149
57MP0000747_muscle_weakness1.49512972
58MP0004510_myositis1.49366846
59MP0002184_abnormal_innervation1.46514062
60MP0005375_adipose_tissue_phenotype1.46322597
61MP0010630_abnormal_cardiac_muscle1.45491407
62MP0001502_abnormal_circadian_rhythm1.44987847
63MP0002733_abnormal_thermal_nociception1.42882182
64MP0003283_abnormal_digestive_organ1.41848065
65MP0001849_ear_inflammation1.39564145
66MP0002249_abnormal_larynx_morphology1.39554667
67MP0003566_abnormal_cell_adhesion1.38520658
68MP0004858_abnormal_nervous_system1.37008851
69MP0008961_abnormal_basal_metabolism1.35072176
70MP0002909_abnormal_adrenal_gland1.34951275
71MP0000759_abnormal_skeletal_muscle1.29412833
72MP0000566_synostosis1.28612574
73MP0003279_aneurysm1.28526273
74MP0002971_abnormal_brown_adipose1.26067877
75MP0000733_abnormal_muscle_development1.25221443
76MP0001177_atelectasis1.24508024
77MP0001666_abnormal_nutrient_absorption1.21098598
78MP0002896_abnormal_bone_mineralization1.21081273
79MP0004484_altered_response_of1.19807789
80MP0005385_cardiovascular_system_phenoty1.19360841
81MP0001544_abnormal_cardiovascular_syste1.19360841
82MP0003633_abnormal_nervous_system1.18237956
83MP0002106_abnormal_muscle_physiology1.17990514
84MP0002127_abnormal_cardiovascular_syste1.16739851
85MP0000003_abnormal_adipose_tissue1.16172802
86MP0003941_abnormal_skin_development1.16153380
87MP0005369_muscle_phenotype1.15678909
88MP0004185_abnormal_adipocyte_glucose1.15368246
89MP0005409_darkened_coat_color1.15325006
90MP0001879_abnormal_lymphatic_vessel1.15112921
91MP0002066_abnormal_motor_capabilities/c1.13435395
92MP0003950_abnormal_plasma_membrane1.13062347
93MP0003453_abnormal_keratinocyte_physiol1.12854571
94MP0004215_abnormal_myocardial_fiber1.12145280
95MP0000955_abnormal_spinal_cord1.12062043
96MP0004885_abnormal_endolymph1.11547415
97MP0000750_abnormal_muscle_regeneration1.11122082
98MP0001958_emphysema1.11085737
99MP0004782_abnormal_surfactant_physiolog1.10948238
100MP0002882_abnormal_neuron_morphology1.10549296
101MP0005167_abnormal_blood-brain_barrier1.10438433
102MP0008775_abnormal_heart_ventricle1.09928127
103MP0004085_abnormal_heartbeat1.09128442
104MP0005085_abnormal_gallbladder_physiolo1.08139278
105MP0003868_abnormal_feces_composition1.07838002
106MP0000751_myopathy1.07463377
107MP0005084_abnormal_gallbladder_morpholo1.04474261
108MP0000537_abnormal_urethra_morphology1.04078831
109MP0003183_abnormal_peptide_metabolism1.04009096
110MP0004742_abnormal_vestibular_system1.02931020
111MP0000534_abnormal_ureter_morphology1.01659775
112MP0002269_muscular_atrophy1.01650449
113MP0002098_abnormal_vibrissa_morphology1.01629716
114MP0002876_abnormal_thyroid_physiology1.01324404
115MP0001664_abnormal_digestion1.01298438
116MP0000467_abnormal_esophagus_morphology1.00956683
117MP0001984_abnormal_olfaction1.00094969
118MP0009840_abnormal_foam_cell0.99354120
119MP0000230_abnormal_systemic_arterial0.98017030
120MP0000631_abnormal_neuroendocrine_gland0.97954716
121MP0000579_abnormal_nail_morphology0.97834207
122MP0000762_abnormal_tongue_morphology0.96808520
123MP0005501_abnormal_skin_physiology0.96113102
124MP0005595_abnormal_vascular_smooth0.94097999
125MP0003091_abnormal_cell_migration0.94074291
126MP0002152_abnormal_brain_morphology0.92629457
127MP0005076_abnormal_cell_differentiation0.92399181
128MP0003075_altered_response_to0.91373575
129MP0009384_cardiac_valve_regurgitation0.90219918
130MP0010386_abnormal_urinary_bladder0.90154607
131MP0002060_abnormal_skin_morphology0.89276724
132MP0003631_nervous_system_phenotype0.88532647
133MP0009115_abnormal_fat_cell0.88380755
134MP0005171_absent_coat_pigmentation0.87953518
135MP0000767_abnormal_smooth_muscle0.87674462
136MP0001661_extended_life_span0.87610999
137MP0001963_abnormal_hearing_physiology0.86840817
138MP0008874_decreased_physiological_sensi0.85934391
139MP0002837_dystrophic_cardiac_calcinosis0.84510415
140MP0002069_abnormal_eating/drinking_beha0.84458281
141MP0005451_abnormal_body_composition0.79991565
142MP0000477_abnormal_intestine_morphology0.79025873
143MP0000681_abnormal_thyroid_gland0.78975637
144MP0005165_increased_susceptibility_to0.77927612
145MP0000538_abnormal_urinary_bladder0.77654067
146MP0000015_abnormal_ear_pigmentation0.77575001
147MP0001905_abnormal_dopamine_level0.77395417
148MP0003191_abnormal_cellular_cholesterol0.77363892
149MP0005023_abnormal_wound_healing0.76765211
150MP0003122_maternal_imprinting0.74068114
151MP0003045_fibrosis0.71169799
152MP0002972_abnormal_cardiac_muscle0.70668426
153MP0001529_abnormal_vocalization0.70145978
154MP0008004_abnormal_stomach_pH0.69973837
155MP0004147_increased_porphyrin_level0.69708714
156MP0005623_abnormal_meninges_morphology0.67487688
157MP0004084_abnormal_cardiac_muscle0.66503885
158MP0004130_abnormal_muscle_cell0.65567534
159MP0001765_abnormal_ion_homeostasis0.63512031
160MP0006292_abnormal_olfactory_placode0.63006044
161MP0005535_abnormal_body_temperature0.61868987
162MP0005620_abnormal_muscle_contractility0.61380659
163MP0005166_decreased_susceptibility_to0.57831761
164MP0006276_abnormal_autonomic_nervous0.57379957
165MP0004142_abnormal_muscle_tone0.57257134
166MP0000678_abnormal_parathyroid_gland0.56777035
167MP0000026_abnormal_inner_ear0.55607270
168MP0003690_abnormal_glial_cell0.54845338
169MP0002638_abnormal_pupillary_reflex0.54105375
170MP0003137_abnormal_impulse_conducting0.52025316
171MP0001943_abnormal_respiration0.50729767
172MP0004036_abnormal_muscle_relaxation0.50015047
173MP0005551_abnormal_eye_electrophysiolog0.47406828
174MP0008872_abnormal_physiological_respon0.45480084
175MP0010770_preweaning_lethality0.45409420

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.41726952
2Myokymia (HP:0002411)6.11037890
3Epileptic encephalopathy (HP:0200134)4.89354915
4Focal seizures (HP:0007359)4.79164279
5Febrile seizures (HP:0002373)4.78858862
6Right ventricular cardiomyopathy (HP:0011663)4.46233290
7Hyperventilation (HP:0002883)4.22709359
8Progressive cerebellar ataxia (HP:0002073)4.08098282
9Visual hallucinations (HP:0002367)4.07803139
10Type 1 muscle fiber predominance (HP:0003803)3.95903595
11Hyporeflexia of lower limbs (HP:0002600)3.74338890
12Broad-based gait (HP:0002136)3.70050095
13Aortic aneurysm (HP:0004942)3.46087120
14Poor eye contact (HP:0000817)3.37347789
15Ventricular tachycardia (HP:0004756)3.36636517
16Muscle fiber splitting (HP:0003555)3.35958472
17Impaired vibration sensation in the lower limbs (HP:0002166)3.34823429
18Distal lower limb muscle weakness (HP:0009053)3.32129675
19Papilledema (HP:0001085)3.30883366
20Mildly elevated creatine phosphokinase (HP:0008180)3.26048468
21Protruding tongue (HP:0010808)3.22902022
22Exercise-induced myalgia (HP:0003738)3.18385273
23Increased connective tissue (HP:0009025)3.12711873
24Generalized tonic-clonic seizures (HP:0002069)3.12409952
25Increased variability in muscle fiber diameter (HP:0003557)3.05694764
26Malnutrition (HP:0004395)3.04230252
27Urinary bladder sphincter dysfunction (HP:0002839)3.01722690
28Atonic seizures (HP:0010819)2.96267935
29Genetic anticipation (HP:0003743)2.95947075
30Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.90439122
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.90095753
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.89078148
33Muscle fiber inclusion bodies (HP:0100299)2.88765344
34Cerebral aneurysm (HP:0004944)2.87163725
35Absence seizures (HP:0002121)2.84076734
36Abnormality of skeletal muscle fiber size (HP:0012084)2.83079276
37Abnormality of the right ventricle (HP:0001707)2.81766912
38Abnormal social behavior (HP:0012433)2.80599270
39Impaired social interactions (HP:0000735)2.80599270
40Abnormality of the calf musculature (HP:0001430)2.79074212
41Distal lower limb amyotrophy (HP:0008944)2.76953585
42Decreased circulating renin level (HP:0003351)2.74099894
43Stereotypic behavior (HP:0000733)2.73762638
44Round ear (HP:0100830)2.72918497
45Nemaline bodies (HP:0003798)2.71228048
46Myopathic facies (HP:0002058)2.67700923
47Gaze-evoked nystagmus (HP:0000640)2.65972683
48Ankle clonus (HP:0011448)2.64281599
49Chronic otitis media (HP:0000389)2.62101652
50Flat acetabular roof (HP:0003180)2.61298137
51Dialeptic seizures (HP:0011146)2.59979684
52Mutism (HP:0002300)2.59423320
53Asymmetric septal hypertrophy (HP:0001670)2.59169631
54Excessive salivation (HP:0003781)2.54943241
55Drooling (HP:0002307)2.54943241
56Lipoatrophy (HP:0100578)2.54191704
57Action tremor (HP:0002345)2.54186197
58Aortic dissection (HP:0002647)2.53847453
59Lymphangioma (HP:0100764)2.53483868
60Prolonged QT interval (HP:0001657)2.52357853
61Abnormal atrioventricular conduction (HP:0005150)2.48467692
62Distal arthrogryposis (HP:0005684)2.48180758
63Metabolic alkalosis (HP:0200114)2.46215286
64Absent speech (HP:0001344)2.44226483
65Bundle branch block (HP:0011710)2.43797524
66Generalized hypopigmentation of hair (HP:0011358)2.43445533
67Depression (HP:0000716)2.42229847
68Neck muscle weakness (HP:0000467)2.41010131
69Thin bony cortex (HP:0002753)2.40828675
70Inappropriate behavior (HP:0000719)2.39450084
71Abnormal eating behavior (HP:0100738)2.39339214
72Spinal rigidity (HP:0003306)2.38528924
73Postural instability (HP:0002172)2.37818725
74Heart block (HP:0012722)2.36097468
75Abnormal EKG (HP:0003115)2.34425340
76Lower limb amyotrophy (HP:0007210)2.34230747
77Complement deficiency (HP:0004431)2.34172423
78Amblyopia (HP:0000646)2.32929851
79Atrial fibrillation (HP:0005110)2.32775668
80Atrioventricular block (HP:0001678)2.31835131
81Protrusio acetabuli (HP:0003179)2.31211611
82Abnormality of complement system (HP:0005339)2.29789891
83Primary atrial arrhythmia (HP:0001692)2.28582434
84Aqueductal stenosis (HP:0002410)2.28025140
85Syncope (HP:0001279)2.26449864
86Dilated cardiomyopathy (HP:0001644)2.26182472
87Osteolytic defects of the phalanges of the hand (HP:0009771)2.25814712
88Osteolytic defects of the hand bones (HP:0009699)2.25814712
89Abnormality of the left ventricular outflow tract (HP:0011103)2.23056834
90Subaortic stenosis (HP:0001682)2.23056834
91EMG: myopathic abnormalities (HP:0003458)2.22369284
92Ventricular arrhythmia (HP:0004308)2.22306567
93Anxiety (HP:0000739)2.22161323
94Aneurysm (HP:0002617)2.20664603
95Hip contracture (HP:0003273)2.20270131
96Bradycardia (HP:0001662)2.19652032
97Hyperparathyroidism (HP:0000843)2.18229846
98Fetal akinesia sequence (HP:0001989)2.16516379
99Truncal ataxia (HP:0002078)2.16182678
100Blue irides (HP:0000635)2.15651698
101Sudden death (HP:0001699)2.15542486
102Inability to walk (HP:0002540)2.12238821
103Neoplasm of the heart (HP:0100544)2.10868452
104Obstructive sleep apnea (HP:0002870)2.09808043
105Supraventricular tachycardia (HP:0004755)2.09591865
106Impaired vibratory sensation (HP:0002495)2.07867104
107Visceral angiomatosis (HP:0100761)2.07611337
108Ileus (HP:0002595)2.07446940
109Abnormality of the lower motor neuron (HP:0002366)2.06976081
110Ulnar deviation of the wrist (HP:0003049)2.06486188
111Agitation (HP:0000713)2.06162806
112Polyphagia (HP:0002591)2.05955739
113Epileptiform EEG discharges (HP:0011182)2.05512932
114Supraventricular arrhythmia (HP:0005115)2.04124190
115Broad metatarsal (HP:0001783)2.03771186
116Abnormality of salivation (HP:0100755)2.03329254
117Difficulty running (HP:0009046)2.03216876
118Panhypogammaglobulinemia (HP:0003139)2.03104470
119Impaired smooth pursuit (HP:0007772)2.02761722
120Bulbar palsy (HP:0001283)2.01231029
121Hyperactive renin-angiotensin system (HP:0000841)2.00407583
122Hemorrhage of the eye (HP:0011885)1.99063778
123Dysmetria (HP:0001310)1.98610580
124Ankyloglossia (HP:0010296)1.98115361
125Broad face (HP:0000283)1.97938313
126Scapular winging (HP:0003691)1.96060999
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.95570120
128Widely spaced teeth (HP:0000687)1.94294932
129EMG: neuropathic changes (HP:0003445)1.93955285
130Ventricular fibrillation (HP:0001663)1.93452312
131Open mouth (HP:0000194)1.92455104
132Hydroxyprolinuria (HP:0003080)1.91471162
133Abnormality of proline metabolism (HP:0010907)1.91471162
134Hemangiomatosis (HP:0007461)1.91168417
135Bronchomalacia (HP:0002780)1.89509338
136Shallow orbits (HP:0000586)1.89316831
137EEG with generalized epileptiform discharges (HP:0011198)1.87011345
138Wide cranial sutures (HP:0010537)1.86587103
139Urinary urgency (HP:0000012)1.86502414
140Fair hair (HP:0002286)1.85871215
141Limited hip movement (HP:0008800)1.85704806
142Muscle hypertrophy of the lower extremities (HP:0008968)1.85573004
143Torticollis (HP:0000473)1.85430581
144Viral hepatitis (HP:0006562)1.85399560
145Systemic lupus erythematosus (HP:0002725)1.83988055
146Dynein arm defect of respiratory motile cilia (HP:0012255)1.83927458
147Absent/shortened dynein arms (HP:0200106)1.83927458
148Dysdiadochokinesis (HP:0002075)1.83583868
149Scanning speech (HP:0002168)1.83338664
150Elfin facies (HP:0004428)1.82194297
151Calf muscle hypertrophy (HP:0008981)1.81927193
152Dysmetric saccades (HP:0000641)1.81917393
153Intellectual disability, profound (HP:0002187)1.80753480
154Akinesia (HP:0002304)1.80422557
155Neoplasm of the adrenal cortex (HP:0100641)1.78506655
156Autism (HP:0000717)1.78299462
157Germ cell neoplasia (HP:0100728)1.78274096
158Growth hormone deficiency (HP:0000824)1.77507515
159Premature rupture of membranes (HP:0001788)1.77442285
160Deeply set eye (HP:0000490)1.77295958
161Hyperkalemia (HP:0002153)1.76336065
162Acanthosis nigricans (HP:0000956)1.76302969
163Pointed chin (HP:0000307)1.75706187
164Focal dystonia (HP:0004373)1.75554333
165Hypercortisolism (HP:0001578)1.75302926
166Exotropia (HP:0000577)1.75294156
167Wormian bones (HP:0002645)1.75068158
168Fragile skin (HP:0001030)1.74821586
169Foot dorsiflexor weakness (HP:0009027)1.74787708
170Hypsarrhythmia (HP:0002521)1.74616301
171Abnormality of the periventricular white matter (HP:0002518)1.74537641
172Large eyes (HP:0001090)1.74380828
173Abnormality of monocarboxylic acid metabolism (HP:0010996)1.72826207
174Pheochromocytoma (HP:0002666)1.72669584
175Tented upper lip vermilion (HP:0010804)1.72254149
176Absent frontal sinuses (HP:0002688)1.71524951
177Abnormality of binocular vision (HP:0011514)1.71123683
178Diplopia (HP:0000651)1.71123683
179Hyperacusis (HP:0010780)1.70702411
180Pili torti (HP:0003777)1.70581585
181Abnormality of renin-angiotensin system (HP:0000847)1.70342219
182Abnormality of the foot musculature (HP:0001436)1.67772973
183Calcaneovalgus deformity (HP:0001848)1.67111843
184Ulnar bowing (HP:0003031)1.66595303
185Difficulty climbing stairs (HP:0003551)1.66088893
186Rectal prolapse (HP:0002035)1.65575183

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.25918135
2EPHA43.94832099
3NTRK33.83015009
4TTN3.74611565
5MARK13.55435768
6CASK3.33664320
7CCNB12.77666983
8EEF2K2.75584282
9OBSCN2.62432496
10DAPK22.62397341
11MAP2K72.54215227
12EPHA22.50316856
13MAP3K92.43400434
14MST1R2.25791820
15PDGFRA2.23158830
16MAP3K42.22049832
17MINK12.17756516
18PRPF4B2.09680397
19TNIK2.07279090
20CAMKK12.06022755
21RIPK42.03488797
22PKN22.01065311
23KSR11.96102465
24MAP3K121.95140987
25MAP3K101.92390905
26LATS21.87233570
27ERN11.85433805
28DAPK11.82560247
29ICK1.81969301
30MAPKAPK31.79971769
31NTRK21.73506959
32PAK61.67757631
33PLK21.64839940
34DDR21.59764718
35SIK11.55347874
36MAPK131.54499471
37SIK31.53921586
38FGFR41.53290911
39MET1.53205692
40SGK21.51682655
41LATS11.50216268
42SIK21.50136522
43MAP3K61.49691643
44CDK51.36665181
45PRKD31.36236705
46UHMK11.33409529
47TRPM71.29569143
48SGK31.27848594
49SMG11.26439847
50PTK21.24102076
51STK381.21127991
52SGK4941.21109574
53SGK2231.21109574
54OXSR11.20293117
55TESK11.18467609
56CAMK11.15672290
57KSR21.15359683
58CDK191.12934410
59MAP3K141.12860879
60PTK61.10934804
61EPHA31.09573594
62MAP2K41.06863189
63MTOR1.06851655
64FES1.04479418
65SGK11.01328647
66LMTK20.99427617
67PRKG20.97639053
68BMPR20.96110130
69STK110.95884233
70EPHB10.94509464
71PRKCG0.93792405
72PHKG20.91337026
73PHKG10.91337026
74PRKAA20.90349619
75ERBB30.90002895
76RPS6KA20.87807620
77INSRR0.86980671
78CAMKK20.86072695
79CAMK2A0.83434966
80RPS6KB20.83343369
81PAK20.82301269
82NTRK10.79253095
83WNK30.78953328
84PKN10.78276333
85PDK10.77736097
86MAP3K20.77060977
87FRK0.76767796
88CLK10.76123551
89MARK20.74920011
90PRKCH0.74873575
91ROCK10.74293046
92CAMK2G0.73576761
93GRK50.73487221
94AKT30.72899757
95MAP2K20.72706686
96MELK0.72384728
97PDGFRB0.72173119
98TEC0.70922764
99MAP3K70.68988575
100TIE10.68856731
101CAMK2D0.68389533
102MAPK70.67791946
103ACVR1B0.67064779
104TAOK10.66646637
105FGFR30.66334081
106ILK0.66083283
107RPS6KC10.63621459
108RPS6KL10.63621459
109MAPK40.63507966
110PRKCE0.63452751
111CAMK40.60992855
112MUSK0.60816875
113PAK30.60754955
114PRKAA10.59183828
115CDK180.58808346
116MAP2K10.58125741
117PTK2B0.58118869
118PDPK10.57561013
119PRKD10.56751713
120MAP3K10.55110983
121MAPK110.54275242
122MYLK0.54018117
123DMPK0.53353401
124STK38L0.53156252
125CAMK2B0.52543747
126PIK3CA0.52140701
127BRSK10.51778413
128CDK150.51116121
129RET0.50811091
130AKT20.48326794
131MAPK150.47719727
132STK240.47564829
133DAPK30.47300770
134NEK90.46972825
135SYK0.46899012
136ZAK0.46416405
137CDK120.46303630
138RPS6KA60.45946493
139DYRK1A0.45620395
140PRKD20.45606409
141PIK3CG0.44015964
142CDC42BPA0.43269631
143FER0.42808563
144RIPK10.42672453
145NEK60.42660616
146PLK30.42643480
147ERBB20.41960641
148RPS6KA30.41714131
149MAPK120.41577485
150NLK0.40288627
151YES10.39774177
152EPHB20.39343426
153CDK140.38860876
154MAP3K130.38080316
155PRKCQ0.37897881
156BCR0.37057180
157BMX0.36054620
158CDK11A0.35832206
159FYN0.35726746
160HIPK20.35099365
161PAK40.34779114
162PINK10.34618487
163CDK30.33933278
164ROCK20.33393197

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97106739
2Olfactory transduction_Homo sapiens_hsa047402.81999345
3Cyanoamino acid metabolism_Homo sapiens_hsa004602.65360285
4Synaptic vesicle cycle_Homo sapiens_hsa047212.58961565
5Circadian entrainment_Homo sapiens_hsa047132.54628327
6Morphine addiction_Homo sapiens_hsa050322.34956830
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.29141730
8Long-term potentiation_Homo sapiens_hsa047202.24374853
9Glutamatergic synapse_Homo sapiens_hsa047242.23694237
10Amphetamine addiction_Homo sapiens_hsa050312.12840513
11Salivary secretion_Homo sapiens_hsa049702.03796680
12GABAergic synapse_Homo sapiens_hsa047272.03769359
13Histidine metabolism_Homo sapiens_hsa003401.97596248
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92208731
15Insulin secretion_Homo sapiens_hsa049111.88945913
16Renin-angiotensin system_Homo sapiens_hsa046141.88265094
17Cholinergic synapse_Homo sapiens_hsa047251.84946695
18Fat digestion and absorption_Homo sapiens_hsa049751.84387167
19Gastric acid secretion_Homo sapiens_hsa049711.82858672
20Dopaminergic synapse_Homo sapiens_hsa047281.81729756
21Arginine biosynthesis_Homo sapiens_hsa002201.78825808
22Protein digestion and absorption_Homo sapiens_hsa049741.76295503
23PPAR signaling pathway_Homo sapiens_hsa033201.73909240
24Renin secretion_Homo sapiens_hsa049241.69781910
25Phenylalanine metabolism_Homo sapiens_hsa003601.68063944
26Bile secretion_Homo sapiens_hsa049761.64138035
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.61415279
28Oxytocin signaling pathway_Homo sapiens_hsa049211.60406456
29Calcium signaling pathway_Homo sapiens_hsa040201.59696895
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.53342597
31Taste transduction_Homo sapiens_hsa047421.51160799
32Serotonergic synapse_Homo sapiens_hsa047261.50364513
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48008775
34Vitamin digestion and absorption_Homo sapiens_hsa049771.45673851
35Cocaine addiction_Homo sapiens_hsa050301.44260728
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42649141
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37980467
38Long-term depression_Homo sapiens_hsa047301.36059615
39ECM-receptor interaction_Homo sapiens_hsa045121.35483550
40Axon guidance_Homo sapiens_hsa043601.35461087
41Type II diabetes mellitus_Homo sapiens_hsa049301.31744006
42GnRH signaling pathway_Homo sapiens_hsa049121.29833142
43cAMP signaling pathway_Homo sapiens_hsa040241.28709427
44Focal adhesion_Homo sapiens_hsa045101.26645072
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25316267
46Gap junction_Homo sapiens_hsa045401.24413319
47Fatty acid degradation_Homo sapiens_hsa000711.24165162
48Tight junction_Homo sapiens_hsa045301.23988045
49Glioma_Homo sapiens_hsa052141.21490717
50Fructose and mannose metabolism_Homo sapiens_hsa000511.18535537
51Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18337388
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17306959
53ErbB signaling pathway_Homo sapiens_hsa040121.16782691
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14609745
55Dilated cardiomyopathy_Homo sapiens_hsa054141.12777081
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09150037
57Starch and sucrose metabolism_Homo sapiens_hsa005001.09036074
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08948152
59Collecting duct acid secretion_Homo sapiens_hsa049661.06821791
60Notch signaling pathway_Homo sapiens_hsa043301.05039792
61Arginine and proline metabolism_Homo sapiens_hsa003301.04797281
62AMPK signaling pathway_Homo sapiens_hsa041521.01391688
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01198601
64Estrogen signaling pathway_Homo sapiens_hsa049150.99593032
65Tyrosine metabolism_Homo sapiens_hsa003500.99295799
66Melanogenesis_Homo sapiens_hsa049160.97602410
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96941511
68Insulin resistance_Homo sapiens_hsa049310.95864980
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95779100
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.95539579
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.95155924
72Insulin signaling pathway_Homo sapiens_hsa049100.95111687
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.94182749
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92168178
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90146863
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89175254
77Adherens junction_Homo sapiens_hsa045200.88297077
78Chemical carcinogenesis_Homo sapiens_hsa052040.87550417
79Retinol metabolism_Homo sapiens_hsa008300.87000154
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.86461971
81Amoebiasis_Homo sapiens_hsa051460.86084786
82Dorso-ventral axis formation_Homo sapiens_hsa043200.83530588
83Glycerolipid metabolism_Homo sapiens_hsa005610.82509536
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81096184
85Tryptophan metabolism_Homo sapiens_hsa003800.79920494
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79628146
87African trypanosomiasis_Homo sapiens_hsa051430.75393989
88Ras signaling pathway_Homo sapiens_hsa040140.75269915
89MAPK signaling pathway_Homo sapiens_hsa040100.75252475
90Endometrial cancer_Homo sapiens_hsa052130.74581139
91Chemokine signaling pathway_Homo sapiens_hsa040620.74506325
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74082078
93Sulfur metabolism_Homo sapiens_hsa009200.73563270
94Prion diseases_Homo sapiens_hsa050200.72929670
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72882253
96Phototransduction_Homo sapiens_hsa047440.72874873
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72421515
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.72330822
99Rap1 signaling pathway_Homo sapiens_hsa040150.71328479
100Galactose metabolism_Homo sapiens_hsa000520.70828475
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.70420231
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.70072273
103Pancreatic secretion_Homo sapiens_hsa049720.70068777
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68025672
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67840026
106Platelet activation_Homo sapiens_hsa046110.65981222
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65305675
108Choline metabolism in cancer_Homo sapiens_hsa052310.65189789
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64020152
110Vibrio cholerae infection_Homo sapiens_hsa051100.63302982
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63121023
112Linoleic acid metabolism_Homo sapiens_hsa005910.62493100
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62338286
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61554234
115Alcoholism_Homo sapiens_hsa050340.61259500
116Ovarian steroidogenesis_Homo sapiens_hsa049130.60882644
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.60472202
118VEGF signaling pathway_Homo sapiens_hsa043700.60402640
119Inositol phosphate metabolism_Homo sapiens_hsa005620.58918781
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57955620
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57938739
122Thyroid hormone synthesis_Homo sapiens_hsa049180.57908162
123Non-small cell lung cancer_Homo sapiens_hsa052230.57728642
124Cardiac muscle contraction_Homo sapiens_hsa042600.56427537
125Circadian rhythm_Homo sapiens_hsa047100.55347827
126Arachidonic acid metabolism_Homo sapiens_hsa005900.55199566
127Colorectal cancer_Homo sapiens_hsa052100.54509515
128B cell receptor signaling pathway_Homo sapiens_hsa046620.53115661
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53048939
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.53027248
131Proteoglycans in cancer_Homo sapiens_hsa052050.52136997
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51829944
133Type I diabetes mellitus_Homo sapiens_hsa049400.51779398
134Lysine degradation_Homo sapiens_hsa003100.51778526
135Oocyte meiosis_Homo sapiens_hsa041140.51751502
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51343896
137Salmonella infection_Homo sapiens_hsa051320.50180431
138Chronic myeloid leukemia_Homo sapiens_hsa052200.49444049
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48903169
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48539883
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.48514618
142Renal cell carcinoma_Homo sapiens_hsa052110.47309776
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46209022
144Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44706278
145Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.44142974
146Wnt signaling pathway_Homo sapiens_hsa043100.43931043
147Mineral absorption_Homo sapiens_hsa049780.43351276
148Glucagon signaling pathway_Homo sapiens_hsa049220.42644606
149Pancreatic cancer_Homo sapiens_hsa052120.42429800
150Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40971285
151Rheumatoid arthritis_Homo sapiens_hsa053230.40480840
152Tuberculosis_Homo sapiens_hsa051520.40430004

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