NEURL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)8.43733643
2muscle filament sliding (GO:0030049)8.43733643
3* sarcomere organization (GO:0045214)8.18495408
4cardiac myofibril assembly (GO:0055003)7.80735229
5myofibril assembly (GO:0030239)7.08709642
6actin-mediated cell contraction (GO:0070252)6.82044436
7cardiac muscle cell development (GO:0055013)6.46901001
8cardiac muscle contraction (GO:0060048)6.36770189
9heart process (GO:0003015)6.23140666
10heart contraction (GO:0060047)6.23140666
11cardiac cell development (GO:0055006)6.13529798
12tricarboxylic acid cycle (GO:0006099)5.97257804
13cardiac muscle tissue morphogenesis (GO:0055008)5.96022741
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.93913823
15oxidative phosphorylation (GO:0006119)5.54444779
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.51558679
17ATP synthesis coupled proton transport (GO:0015986)5.51558679
18ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.48613376
19regulation of skeletal muscle contraction (GO:0014819)5.42924106
20regulation of relaxation of muscle (GO:1901077)5.32783253
21muscle tissue morphogenesis (GO:0060415)5.32155640
22striated muscle contraction (GO:0006941)5.18880366
23cardiac muscle hypertrophy (GO:0003300)5.17866942
24* actomyosin structure organization (GO:0031032)5.12556037
25negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.97932830
26actin filament-based movement (GO:0030048)4.93165184
27striated muscle hypertrophy (GO:0014897)4.87018635
28negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.86505335
29positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.84910447
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.84023761
31respiratory electron transport chain (GO:0022904)4.82029074
32adult heart development (GO:0007512)4.77706956
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.72008987
34regulation of actin filament-based movement (GO:1903115)4.70344155
35electron transport chain (GO:0022900)4.68169780
36muscle hypertrophy (GO:0014896)4.67049139
37NADH metabolic process (GO:0006734)4.66927830
38regulation of sarcomere organization (GO:0060297)4.57911303
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.30646420
40negative regulation of potassium ion transmembrane transport (GO:1901380)4.30639318
41ventricular cardiac muscle cell development (GO:0055015)4.29859473
42heart trabecula formation (GO:0060347)4.28183573
43regulation of the force of heart contraction (GO:0002026)4.24128755
44plasma membrane repair (GO:0001778)4.21756093
45regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.12734306
46cytidine metabolic process (GO:0046087)4.09761457
47cytidine catabolic process (GO:0006216)4.09761457
48cytidine deamination (GO:0009972)4.09761457
49pinocytosis (GO:0006907)4.08160186
50regulation of ATP catabolic process (GO:1903289)3.92106543
51regulation of ATPase activity (GO:0043462)3.92106543
52ubiquinone biosynthetic process (GO:0006744)3.90941327
53quinone biosynthetic process (GO:1901663)3.90941327
54regulation of acyl-CoA biosynthetic process (GO:0050812)3.90693397
55purine nucleotide salvage (GO:0032261)3.90118277
56regulation of striated muscle contraction (GO:0006942)3.83435506
57regulation of cofactor metabolic process (GO:0051193)3.81123592
58regulation of coenzyme metabolic process (GO:0051196)3.81123592
59nucleotide salvage (GO:0043173)3.81021724
60adenosine receptor signaling pathway (GO:0001973)3.79666588
61negative regulation of striated muscle cell apoptotic process (GO:0010664)3.78570938
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74820855
63mitochondrial respiratory chain complex I assembly (GO:0032981)3.74820855
64NADH dehydrogenase complex assembly (GO:0010257)3.74820855
65regulation of cardioblast differentiation (GO:0051890)3.73371654
66ventricular cardiac muscle cell action potential (GO:0086005)3.72417066
67striated muscle cell development (GO:0055002)3.70647630
68negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.60535636
69regulation of cell communication by electrical coupling (GO:0010649)3.57717683
70sarcoplasmic reticulum calcium ion transport (GO:0070296)3.57332625
71oxaloacetate metabolic process (GO:0006107)3.51192408
72cardiac muscle adaptation (GO:0014887)3.47136328
73cardiac muscle hypertrophy in response to stress (GO:0014898)3.47136328
74muscle hypertrophy in response to stress (GO:0003299)3.47136328
75regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.45626854
76skeletal muscle contraction (GO:0003009)3.42110866
77bundle of His cell to Purkinje myocyte communication (GO:0086069)3.42038078
78negative regulation of nitric-oxide synthase activity (GO:0051001)3.41478220
79ATP biosynthetic process (GO:0006754)3.39828416
80response to muscle activity (GO:0014850)3.39366967
81pyrimidine ribonucleoside catabolic process (GO:0046133)3.38648295
82regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.38166939
83ubiquinone metabolic process (GO:0006743)3.37627103
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.36871990
85glycosphingolipid catabolic process (GO:0046479)3.30916337
86response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.30691356
87negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.28636492
882-oxoglutarate metabolic process (GO:0006103)3.25590317
89protein complex biogenesis (GO:0070271)3.24540487
90muscle contraction (GO:0006936)3.22874437
91oligosaccharide catabolic process (GO:0009313)3.16352921
92carnitine shuttle (GO:0006853)3.13644945
93NIK/NF-kappaB signaling (GO:0038061)3.13025977
94regulation of cholesterol storage (GO:0010885)3.12356384
95regulation of mitochondrial translation (GO:0070129)3.11420944
96muscle cell development (GO:0055001)3.10387708
97regulation of striated muscle cell apoptotic process (GO:0010662)3.09843949
98mitochondrial respiratory chain complex assembly (GO:0033108)3.09182825
99regulation of sequestering of triglyceride (GO:0010889)3.07121414
100purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.04173868
101purine nucleoside monophosphate biosynthetic process (GO:0009127)3.04173868
102aerobic respiration (GO:0009060)3.02597522
103response to peptidoglycan (GO:0032494)3.02153360
104galactose catabolic process (GO:0019388)3.01980593
105muscle system process (GO:0003012)3.01664509
106positive regulation of lipoprotein lipase activity (GO:0051006)3.00325988
107positive regulation of triglyceride lipase activity (GO:0061365)3.00325988
108cellular response to arsenic-containing substance (GO:0071243)2.98131893
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94565285
110cellular respiration (GO:0045333)2.90757292
111fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.90667462
112regulation of heart rate (GO:0002027)2.89834995
113glycolipid catabolic process (GO:0019377)2.87326710
114positive regulation of protein homodimerization activity (GO:0090073)2.86874688
115regulation of mononuclear cell migration (GO:0071675)2.86700672
116purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86351663
117purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85203335
118low-density lipoprotein particle clearance (GO:0034383)2.84831168
119purine deoxyribonucleotide catabolic process (GO:0009155)2.84189947
120glycolytic process (GO:0006096)2.82771581
121negative regulation of cell size (GO:0045792)2.82263421
122negative regulation of monooxygenase activity (GO:0032769)2.81925484
123positive regulation of myotube differentiation (GO:0010831)2.81720844
124trabecula formation (GO:0060343)2.81061574
125positive regulation of fatty acid biosynthetic process (GO:0045723)2.80516999
126activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.79457297
127creatine metabolic process (GO:0006600)2.79106132
128autophagic vacuole fusion (GO:0000046)2.77458899
129regulation of muscle contraction (GO:0006937)2.77014890
130regulation of membrane repolarization (GO:0060306)2.76390265
131protein insertion into membrane (GO:0051205)2.72711501
132negative regulation of myeloid cell apoptotic process (GO:0033033)2.72465623
133negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.71431140
134immunoglobulin mediated immune response (GO:0016064)2.71045009
135sphingolipid catabolic process (GO:0030149)2.70835663
136deoxyribonucleotide catabolic process (GO:0009264)2.70125279
137cyclooxygenase pathway (GO:0019371)2.69960823
138regulation of immunoglobulin secretion (GO:0051023)2.69930357
139regulation of cytokine secretion involved in immune response (GO:0002739)2.69364645
140cellular response to thyroid hormone stimulus (GO:0097067)2.68754054
141low-density lipoprotein particle remodeling (GO:0034374)2.66253109
142G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.65781291
143mature B cell differentiation involved in immune response (GO:0002313)2.65719093
144regulation of cholesterol esterification (GO:0010872)2.64802261
145membrane lipid catabolic process (GO:0046466)2.63415191
146fat-soluble vitamin biosynthetic process (GO:0042362)2.62857962
147deoxyribose phosphate catabolic process (GO:0046386)2.61058029
148ceramide catabolic process (GO:0046514)2.58913270
149regulation of chemokine biosynthetic process (GO:0045073)2.58651152
150folic acid transport (GO:0015884)2.56858769
151triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.56474740
152activation of MAPKKK activity (GO:0000185)2.56153236
153UV protection (GO:0009650)2.55522126
154regulation of penile erection (GO:0060405)2.55231948
155positive regulation of heat generation (GO:0031652)2.54821635
156germinal center formation (GO:0002467)2.49613749
157mitochondrial genome maintenance (GO:0000002)2.48246636
158negative regulation of nitric oxide biosynthetic process (GO:0045019)2.47662606
159amino sugar catabolic process (GO:0046348)2.47659538
160adhesion of symbiont to host (GO:0044406)2.46738231
161G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.46582740
162N-acetylneuraminate metabolic process (GO:0006054)2.46440860
163positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.45839579
164tumor necrosis factor-mediated signaling pathway (GO:0033209)2.44613810
165pentose-phosphate shunt (GO:0006098)2.44551764
166skeletal muscle fiber development (GO:0048741)2.43538567
167regulation of fever generation (GO:0031620)2.43212881
168NADPH regeneration (GO:0006740)2.41641569
169complement activation, alternative pathway (GO:0006957)2.41400903
170regulation of mitochondrial membrane potential (GO:0051881)2.39997098
171response to thyroid hormone (GO:0097066)2.39397486
172positive regulation of prostaglandin secretion (GO:0032308)2.38813033
173mitochondrial fusion (GO:0008053)2.37965218
174plasma lipoprotein particle clearance (GO:0034381)2.37497133
175endosome to melanosome transport (GO:0035646)2.37230870
176endosome to pigment granule transport (GO:0043485)2.37230870
177negative regulation of cation channel activity (GO:2001258)2.36761008
178skeletal muscle tissue regeneration (GO:0043403)2.35781366
179negative regulation of erythrocyte differentiation (GO:0045647)2.34441242
180purine-containing compound salvage (GO:0043101)2.34340771
181monosaccharide biosynthetic process (GO:0046364)2.33216241
182lysosome organization (GO:0007040)2.32515795
183lytic vacuole organization (GO:0080171)2.32515795
184negative regulation of interleukin-12 production (GO:0032695)2.32197435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.40033631
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.22769353
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.46571645
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.45451645
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.42641921
6* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.38851427
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36638097
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.99736569
9* SRF_21415370_ChIP-Seq_HL-1_Mouse2.98910483
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.97347619
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.94873304
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.89350480
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.87252714
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.85610464
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.53320270
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.45834727
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.38458737
18BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.38044283
19LXR_22292898_ChIP-Seq_THP-1_Human2.30209475
20MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.20975184
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17095757
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14965638
23* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.13296119
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05607616
25* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02377730
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00387379
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.98913199
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98310220
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.89709681
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80675104
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78874843
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.78438687
33DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.78154848
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.78021215
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.78021215
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76668453
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76616736
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.75655118
39VDR_23849224_ChIP-Seq_CD4+_Human1.75335552
40XRN2_22483619_ChIP-Seq_HELA_Human1.73987670
41ELF1_20517297_ChIP-Seq_JURKAT_Human1.73898142
42DCP1A_22483619_ChIP-Seq_HELA_Human1.73324406
43CIITA_25753668_ChIP-Seq_RAJI_Human1.69288203
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67500206
45P68_20966046_ChIP-Seq_HELA_Human1.66980104
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66400307
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66326994
48NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.66020717
49FOXP3_21729870_ChIP-Seq_TREG_Human1.65536928
50GABP_19822575_ChIP-Seq_HepG2_Human1.64473291
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.63362350
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62746265
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60946782
54RXR_22158963_ChIP-Seq_LIVER_Mouse1.57254945
55VDR_24763502_ChIP-Seq_THP-1_Human1.56294118
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.55525494
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55018869
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53905453
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.53258462
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51860393
61* TFEB_21752829_ChIP-Seq_HELA_Human1.49586361
62BCOR_27268052_Chip-Seq_Bcells_Human1.47832689
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46571562
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46136030
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42483070
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42354714
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41014958
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40363535
69NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39720496
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39518297
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38031119
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37442064
73SCL_19346495_ChIP-Seq_HPC-7_Human1.36056663
74CTCF_26484167_Chip-Seq_Bcells_Mouse1.35014577
75GATA1_22025678_ChIP-Seq_K562_Human1.32485193
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31860850
77CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30465448
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29506730
79MAF_26560356_Chip-Seq_TH2_Human1.29209866
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28858079
81* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27685600
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26616307
83* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.25641719
84SPI1_20517297_ChIP-Seq_HL60_Human1.24744722
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24577550
86CTCF_21964334_Chip-Seq_Bcells_Human1.24413064
87PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24302877
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23383347
89RACK7_27058665_Chip-Seq_MCF-7_Human1.22317432
90SA1_27219007_Chip-Seq_ERYTHROID_Human1.21925507
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20981788
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.20547616
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20538581
94LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20259698
95ELK1_19687146_ChIP-ChIP_HELA_Human1.20042784
96ERG_21242973_ChIP-ChIP_JURKAT_Human1.19711081
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19472786
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18836337
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18644152
100* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18241638
101FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17965839
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17594174
103CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17105966
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16676837
105PHF8_20622854_ChIP-Seq_HELA_Human1.15784904
106E2F1_20622854_ChIP-Seq_HELA_Human1.15759264
107* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15709835
108SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15362817
109E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14662277
110MAF_26560356_Chip-Seq_TH1_Human1.14170086
111FOXP1_21924763_ChIP-Seq_HESCs_Human1.14113963
112E2F4_17652178_ChIP-ChIP_JURKAT_Human1.13270640
113PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12497948
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11796234
115RARA_24833708_ChIP-Seq_LIVER_Mouse1.11681114
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11614580
117VDR_21846776_ChIP-Seq_THP-1_Human1.11127942
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10169980
119* TTF2_22483619_ChIP-Seq_HELA_Human1.10060308
120STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08454946
121ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07950377
122MYC_22102868_ChIP-Seq_BL_Human1.06512083
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06364613
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05854614
125PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.04362886
126CLOCK_20551151_ChIP-Seq_293T_Human1.03144462
127* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.02631901
128ZNF263_19887448_ChIP-Seq_K562_Human1.02043204
129* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01479454
130EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00555711
131AR_21909140_ChIP-Seq_LNCAP_Human1.00354611
132GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99953667
133SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99279182
134YY1_22570637_ChIP-Seq_MALME-3M_Human0.97516599
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97211711
136MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93548678
137PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92532682
138CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91886534
139SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91466632
140SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91305408
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90838637
142BCL6_27268052_Chip-Seq_Bcells_Human0.90800805
143HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90710622
144ELK3_25401928_ChIP-Seq_HUVEC_Human0.89990493
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89768719
146ELK1_22589737_ChIP-Seq_MCF10A_Human0.89670411

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.52649755
2MP0002837_dystrophic_cardiac_calcinosis5.46783220
3MP0003646_muscle_fatigue4.93907104
4MP0000749_muscle_degeneration4.79899172
5MP0000751_myopathy4.32958956
6MP0004036_abnormal_muscle_relaxation4.20716765
7MP0004215_abnormal_myocardial_fiber3.98389282
8MP0005330_cardiomyopathy3.72655470
9MP0002139_abnormal_hepatobiliary_system3.36233783
10MP0002972_abnormal_cardiac_muscle3.02778085
11MP0008775_abnormal_heart_ventricle2.99500067
12MP0004087_abnormal_muscle_fiber2.91427734
13MP0000750_abnormal_muscle_regeneration2.86163630
14MP0003303_peritoneal_inflammation2.81612929
15MP0004510_myositis2.74032116
16MP0005620_abnormal_muscle_contractility2.59748134
17MP0003221_abnormal_cardiomyocyte_apopto2.53793135
18MP0002106_abnormal_muscle_physiology2.52657362
19MP0002269_muscular_atrophy2.47753424
20MP0010630_abnormal_cardiac_muscle2.40617191
21MP0005385_cardiovascular_system_phenoty2.40170179
22MP0001544_abnormal_cardiovascular_syste2.40170179
23MP0006036_abnormal_mitochondrial_physio2.31904713
24MP0006138_congestive_heart_failure2.28954594
25MP0002148_abnormal_hypersensitivity_rea2.25985732
26MP0003137_abnormal_impulse_conducting2.23839323
27MP0003828_pulmonary_edema2.20303652
28MP0004145_abnormal_muscle_electrophysio2.16948202
29MP0005464_abnormal_platelet_physiology2.15662004
30MP0005451_abnormal_body_composition2.09984603
31MP0000747_muscle_weakness2.01736118
32MP0005369_muscle_phenotype1.97413295
33MP0004484_altered_response_of1.97022119
34MP0003950_abnormal_plasma_membrane1.96691720
35* MP0000759_abnormal_skeletal_muscle1.88896633
36MP0002254_reproductive_system_inflammat1.85722530
37MP0009278_abnormal_bone_marrow1.83881654
38MP0004130_abnormal_muscle_cell1.82950507
39MP0001545_abnormal_hematopoietic_system1.81136254
40MP0005397_hematopoietic_system_phenotyp1.81136254
41MP0003191_abnormal_cellular_cholesterol1.78414689
42MP0004085_abnormal_heartbeat1.74509105
43MP0002127_abnormal_cardiovascular_syste1.73576660
44MP0004233_abnormal_muscle_weight1.64674798
45MP0003279_aneurysm1.64090252
46MP0009764_decreased_sensitivity_to1.63562593
47MP0003075_altered_response_to1.62130875
48MP0003567_abnormal_fetal_cardiomyocyte1.53086883
49MP0003436_decreased_susceptibility_to1.52132354
50MP0005167_abnormal_blood-brain_barrier1.51247554
51MP0005670_abnormal_white_adipose1.49390375
52MP0006035_abnormal_mitochondrial_morpho1.48668761
53MP0002332_abnormal_exercise_endurance1.42871975
54MP0002419_abnormal_innate_immunity1.42735492
55MP0009785_altered_susceptibility_to1.41764536
56MP0005310_abnormal_salivary_gland1.40614898
57MP0000858_altered_metastatic_potential1.38648777
58MP0000343_altered_response_to1.34656409
59MP0006082_CNS_inflammation1.29023285
60MP0003300_gastrointestinal_ulcer1.28256363
61MP0005360_urolithiasis1.26287899
62MP0003453_abnormal_keratinocyte_physiol1.22834476
63MP0003806_abnormal_nucleotide_metabolis1.22666222
64MP0008469_abnormal_protein_level1.21003990
65MP0005025_abnormal_response_to1.18615114
66MP0005387_immune_system_phenotype1.17159741
67MP0001790_abnormal_immune_system1.17159741
68MP0000604_amyloidosis1.14795035
69MP0000266_abnormal_heart_morphology1.09149010
70MP0002396_abnormal_hematopoietic_system1.07750567
71MP0005000_abnormal_immune_tolerance1.04537337
72MP0004147_increased_porphyrin_level1.03834151
73MP0005365_abnormal_bile_salt0.99878507
74MP0002998_abnormal_bone_remodeling0.99623401
75MP0006054_spinal_hemorrhage0.96828781
76MP0008004_abnormal_stomach_pH0.95273053
77MP0000685_abnormal_immune_system0.95112769
78MP0001533_abnormal_skeleton_physiology0.93362207
79MP0009840_abnormal_foam_cell0.91976223
80MP0001661_extended_life_span0.90758566
81MP0002452_abnormal_antigen_presenting0.90412348
82MP0002653_abnormal_ependyma_morphology0.89862876
83MP0008260_abnormal_autophagy0.89232048
84MP0003172_abnormal_lysosome_physiology0.89133441
85MP0008874_decreased_physiological_sensi0.88806880
86MP0002971_abnormal_brown_adipose0.86262949
87MP0001849_ear_inflammation0.85402617
88MP0002723_abnormal_immune_serum0.84369784
89MP0001845_abnormal_inflammatory_respons0.84172613
90MP0005058_abnormal_lysosome_morphology0.84019705
91MP0003656_abnormal_erythrocyte_physiolo0.82356720
92MP0001835_abnormal_antigen_presentation0.81040641
93MP0005666_abnormal_adipose_tissue0.80600915
94MP0003448_altered_tumor_morphology0.79157916
95MP0000230_abnormal_systemic_arterial0.78568647
96MP0000767_abnormal_smooth_muscle0.78165262
97MP0005266_abnormal_metabolism0.77303319
98MP0009763_increased_sensitivity_to0.76609763
99MP0002128_abnormal_blood_circulation0.75532767
100MP0003984_embryonic_growth_retardation0.75321602
101MP0004858_abnormal_nervous_system0.75253899
102MP0002088_abnormal_embryonic_growth/wei0.75009500
103MP0005166_decreased_susceptibility_to0.74526759
104MP0008875_abnormal_xenobiotic_pharmacok0.74438454
105MP0008438_abnormal_cutaneous_collagen0.74338939
106MP0003186_abnormal_redox_activity0.73512224
107MP0000609_abnormal_liver_physiology0.72227815
108MP0002090_abnormal_vision0.71717856
109MP0002138_abnormal_hepatobiliary_system0.69007289
110MP0003195_calcinosis0.67803755
111MP0002089_abnormal_postnatal_growth/wei0.65877434
112MP0005319_abnormal_enzyme/_coenzyme0.65354535
113MP0005165_increased_susceptibility_to0.65342021
114MP0001879_abnormal_lymphatic_vessel0.64721622
115MP0001727_abnormal_embryo_implantation0.64134211
116MP0002234_abnormal_pharynx_morphology0.60901670
117MP0001730_embryonic_growth_arrest0.57346295
118MP0010094_abnormal_chromosome_stability0.57028391
119MP0000358_abnormal_cell_content/0.57008562
120MP0002108_abnormal_muscle_morphology0.56661861
121MP0009333_abnormal_splenocyte_physiolog0.54749469
122MP0005380_embryogenesis_phenotype0.51807728
123MP0001672_abnormal_embryogenesis/_devel0.51807728
124MP0000733_abnormal_muscle_development0.50914068
125MP0001614_abnormal_blood_vessel0.50486337
126MP0005375_adipose_tissue_phenotype0.50483555
127MP0001853_heart_inflammation0.49336704
128MP0003693_abnormal_embryo_hatching0.47951827
129MP0002925_abnormal_cardiovascular_devel0.43995777
130MP0004185_abnormal_adipocyte_glucose0.43151234
131MP0009697_abnormal_copulation0.43074984
132MP0003718_maternal_effect0.42245466
133MP0008007_abnormal_cellular_replicative0.41167119
134MP0001697_abnormal_embryo_size0.39661507
135MP0005376_homeostasis/metabolism_phenot0.38424949
136MP0000249_abnormal_blood_vessel0.37677144
137MP0005595_abnormal_vascular_smooth0.37156897
138MP0008058_abnormal_DNA_repair0.35808308
139MP0010368_abnormal_lymphatic_system0.35273957
140MP0003077_abnormal_cell_cycle0.35073090
141MP0002080_prenatal_lethality0.33879265
142MP0009384_cardiac_valve_regurgitation0.33395695
143MP0005257_abnormal_intraocular_pressure0.32600383
144MP0003566_abnormal_cell_adhesion0.32421426
145MP0001764_abnormal_homeostasis0.32398746
146MP0009672_abnormal_birth_weight0.31913327
147MP0005623_abnormal_meninges_morphology0.31576703
148MP0005584_abnormal_enzyme/coenzyme_acti0.31335777
149MP0000598_abnormal_liver_morphology0.31001969
150MP0003123_paternal_imprinting0.29593772
151MP0002132_abnormal_respiratory_system0.29549814
152MP0004957_abnormal_blastocyst_morpholog0.29173540
153MP0001784_abnormal_fluid_regulation0.28145365

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)7.53680632
2Sudden death (HP:0001699)6.44796001
3Exercise-induced myalgia (HP:0003738)6.41653170
4Ventricular tachycardia (HP:0004756)6.11382663
5Calf muscle hypertrophy (HP:0008981)5.92033372
6Muscle hypertrophy of the lower extremities (HP:0008968)5.45999915
7Myoglobinuria (HP:0002913)4.90957691
8Lipoatrophy (HP:0100578)4.89146963
9Abnormality of the calf musculature (HP:0001430)4.82714729
10Abnormality of glycolipid metabolism (HP:0010969)4.70862141
11Abnormality of liposaccharide metabolism (HP:0010968)4.70862141
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.70862141
13Atrial fibrillation (HP:0005110)4.69723413
14Muscle fiber splitting (HP:0003555)4.57357428
15Subaortic stenosis (HP:0001682)4.48675011
16Abnormality of the left ventricular outflow tract (HP:0011103)4.48675011
17Primary atrial arrhythmia (HP:0001692)4.37456207
18Rhabdomyolysis (HP:0003201)4.37240790
19Supraventricular tachycardia (HP:0004755)4.35691749
20EMG: myopathic abnormalities (HP:0003458)4.32722005
21Supraventricular arrhythmia (HP:0005115)4.26208389
22Dilated cardiomyopathy (HP:0001644)4.21211489
23Hepatic necrosis (HP:0002605)4.15318517
24Hepatocellular necrosis (HP:0001404)4.11783371
25Increased cerebral lipofuscin (HP:0011813)4.11538817
26Acute necrotizing encephalopathy (HP:0006965)4.05749748
27Palpitations (HP:0001962)4.03769101
28Abnormal mitochondria in muscle tissue (HP:0008316)3.98964835
29Increased neuronal autofluorescent lipopigment (HP:0002074)3.81342464
30Hyporeflexia of lower limbs (HP:0002600)3.75691719
31Mitochondrial inheritance (HP:0001427)3.74537049
32Myopathic facies (HP:0002058)3.71519684
33Systemic lupus erythematosus (HP:0002725)3.70267018
34Asymmetric septal hypertrophy (HP:0001670)3.69647732
35Right ventricular cardiomyopathy (HP:0011663)3.65235014
36Acute encephalopathy (HP:0006846)3.62080307
37Increased CSF lactate (HP:0002490)3.55157373
38Exercise intolerance (HP:0003546)3.32836478
39Progressive macrocephaly (HP:0004481)3.28926300
40Syncope (HP:0001279)3.24223054
41Ventricular arrhythmia (HP:0004308)3.20523423
42Increased connective tissue (HP:0009025)3.18113462
43Abnormality of glycolysis (HP:0004366)3.17466631
44Increased serum pyruvate (HP:0003542)3.17466631
45Dysostosis multiplex (HP:0000943)3.14880910
46Distal arthrogryposis (HP:0005684)3.13818679
47Ragged-red muscle fibers (HP:0003200)3.10607339
48Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.04865848
49Muscle fiber inclusion bodies (HP:0100299)3.02888098
50Bundle branch block (HP:0011710)2.97331748
51Myotonia (HP:0002486)2.97146085
52Complement deficiency (HP:0004431)2.92531839
53Vacuolated lymphocytes (HP:0001922)2.89234769
54Lactic acidosis (HP:0003128)2.88314826
55Increased serum ferritin (HP:0003281)2.86271284
56Prolonged QT interval (HP:0001657)2.85135591
57Type 1 muscle fiber predominance (HP:0003803)2.83946503
58Round ear (HP:0100830)2.80248428
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.77782090
60Areflexia of lower limbs (HP:0002522)2.75270191
61Neck muscle weakness (HP:0000467)2.74844165
62Muscle stiffness (HP:0003552)2.74437982
63Respiratory failure (HP:0002878)2.74270215
64Left ventricular hypertrophy (HP:0001712)2.73627267
65Atrioventricular block (HP:0001678)2.71808986
66Cerebral edema (HP:0002181)2.70150249
67Heart block (HP:0012722)2.69275905
68Increased serum lactate (HP:0002151)2.62246395
69Paralysis (HP:0003470)2.58724149
70Nemaline bodies (HP:0003798)2.58495772
71Increased muscle lipid content (HP:0009058)2.58384271
72Loss of speech (HP:0002371)2.57553539
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.56282629
74Conjunctival hamartoma (HP:0100780)2.55838437
75Abnormality of polysaccharide metabolism (HP:0011012)2.51769864
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51769864
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51769864
78Abnormal atrioventricular conduction (HP:0005150)2.51412312
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50947811
80Hepatosplenomegaly (HP:0001433)2.49958585
81Rimmed vacuoles (HP:0003805)2.46898652
82Lipid accumulation in hepatocytes (HP:0006561)2.45321783
83Increased intramyocellular lipid droplets (HP:0012240)2.43799680
84Purpura (HP:0000979)2.43721532
85CNS demyelination (HP:0007305)2.43135027
86Neoplasm of the adrenal gland (HP:0100631)2.42961551
87Ulnar deviation of the wrist (HP:0003049)2.42659778
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.42330754
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.42330754
90Multiple enchondromatosis (HP:0005701)2.37749043
91Limb-girdle muscle atrophy (HP:0003797)2.35292722
92Abnormality of iron homeostasis (HP:0011031)2.34483356
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34179833
94Distal lower limb muscle weakness (HP:0009053)2.32416667
95Palmoplantar keratoderma (HP:0000982)2.31267180
96Patent foramen ovale (HP:0001655)2.30220749
97Mucopolysacchariduria (HP:0008155)2.27423865
98Urinary glycosaminoglycan excretion (HP:0003541)2.27423865
99Malignant hyperthermia (HP:0002047)2.26895756
100Prolonged neonatal jaundice (HP:0006579)2.25862347
101Thrombocytosis (HP:0001894)2.25267106
102Mutism (HP:0002300)2.24918128
103Bulbar palsy (HP:0001283)2.23271762
104Hemorrhage of the eye (HP:0011885)2.21927330
105Increased hepatocellular lipid droplets (HP:0006565)2.21696621
106Abnormality of alanine metabolism (HP:0010916)2.21241407
107Hyperalaninemia (HP:0003348)2.21241407
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.21241407
109Renal Fanconi syndrome (HP:0001994)2.21026110
110Difficulty running (HP:0009046)2.19637536
111Achilles tendon contracture (HP:0001771)2.17468993
112Abnormality of complement system (HP:0005339)2.16722840
113Abnormal EKG (HP:0003115)2.15380344
114Ventricular fibrillation (HP:0001663)2.15300662
115Abnormality of the Achilles tendon (HP:0005109)2.14867272
116Abnormality of fatty-acid metabolism (HP:0004359)2.14464152
117Disinhibition (HP:0000734)2.13360180
118Nausea (HP:0002018)2.12631397
119Axonal loss (HP:0003447)2.12231064
120Hypoplastic left heart (HP:0004383)2.11919086
121Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11384619
122Dicarboxylic aciduria (HP:0003215)2.11384619
123Joint stiffness (HP:0001387)2.06632575
124Distal lower limb amyotrophy (HP:0008944)2.06334820
125Testicular atrophy (HP:0000029)2.05162863
126Petechiae (HP:0000967)2.04953538
127Abnormal gallbladder physiology (HP:0012438)2.02589255
128Cholecystitis (HP:0001082)2.02589255
129Muscle fiber atrophy (HP:0100295)2.00351155
130Abnormality of skeletal muscle fiber size (HP:0012084)1.99927824
131Progressive muscle weakness (HP:0003323)1.99573779
132Difficulty climbing stairs (HP:0003551)1.99415387
133Ketoacidosis (HP:0001993)1.97900020
134Generalized muscle weakness (HP:0003324)1.94555914
135Hyperglycinuria (HP:0003108)1.94546436
136Pheochromocytoma (HP:0002666)1.93645779
137Retinal atrophy (HP:0001105)1.92954432
138Neuroendocrine neoplasm (HP:0100634)1.92329943
139Progressive neurologic deterioration (HP:0002344)1.91867988
140Upper motor neuron abnormality (HP:0002127)1.90145780
141Abnormality of lateral ventricle (HP:0030047)1.89857155
142Microvesicular hepatic steatosis (HP:0001414)1.88989050
143Generalized aminoaciduria (HP:0002909)1.88910577
144Emotional lability (HP:0000712)1.88138431
145Frequent falls (HP:0002359)1.87576729
146Gowers sign (HP:0003391)1.85916829
147Increased variability in muscle fiber diameter (HP:0003557)1.85547603
148Esophageal neoplasm (HP:0100751)1.84339585
149Neoplasm of head and neck (HP:0012288)1.84339585
150Congenital malformation of the right heart (HP:0011723)1.84171722
151Glomerulonephritis (HP:0000099)1.82996155
152Joint hemorrhage (HP:0005261)1.81010919
153Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80699967
154Myocardial infarction (HP:0001658)1.78261185
155Xanthomatosis (HP:0000991)1.77979149
156Vertebral compression fractures (HP:0002953)1.76957785
157Abnormality of transition element cation homeostasis (HP:0011030)1.76608017
158Type 2 muscle fiber atrophy (HP:0003554)1.74411578
159Deep venous thrombosis (HP:0002625)1.73744750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.49381301
2MYLK5.39348973
3TTN4.80069723
4TAOK23.42682496
5NEK13.34086139
6ZAK2.95667575
7PHKG12.82641222
8PHKG22.82641222
9VRK22.82027181
10PKN22.70422481
11PRPF4B2.53178063
12STK242.40269123
13PIK3CA2.29916399
14BUB12.19573323
15BCKDK2.10906719
16PDK31.98622976
17PDK41.98622976
18NME21.94932905
19DDR21.92708013
20TAOK11.83111662
21EIF2AK11.81973929
22MUSK1.75984963
23CDK191.68015896
24PLK41.64649501
25STK38L1.62554879
26LIMK11.61676432
27PDK21.42395063
28PBK1.37908942
29TESK11.36560777
30MAP2K31.35522434
31SMG11.34659799
32IKBKB1.34332366
33DAPK31.32673428
34PINK11.30079112
35NME11.30077390
36TRIB31.28206849
37KDR1.26809493
38FLT31.26702336
39MATK1.20811981
40EEF2K1.15010345
41MAPKAPK51.13910222
42DMPK1.13301131
43MAPK121.12933010
44BRSK21.07920648
45BLK1.07328302
46LMTK21.05078769
47ICK1.04299063
48WEE11.02295680
49STK41.02226856
50ILK0.98689643
51SIK10.94048983
52BRAF0.86246136
53MOS0.84197412
54PKN10.82891033
55DYRK1B0.82524274
56IRAK20.78042731
57PAK30.77784922
58ARAF0.77043406
59CDC42BPA0.76045491
60MAP3K10.75155108
61TIE10.74541100
62MAP3K120.74400556
63PRKD20.73653790
64RPS6KL10.72943171
65RPS6KC10.72943171
66MAP3K140.72834126
67MAP3K30.71750828
68CDK80.70035456
69ACVR1B0.68905920
70TRPM70.67803784
71CAMK2D0.67422033
72NEK90.65630213
73ROCK10.65360872
74PRKAA10.64182930
75ABL20.63521723
76TESK20.63343397
77MAPK110.62654197
78MAP3K100.62553574
79RPS6KA60.62357516
80MAP3K50.61717537
81BRSK10.61366057
82PTK2B0.61268049
83AKT20.60759439
84RIPK10.60623563
85JAK30.60306145
86PIM20.60074456
87PRKD10.58003559
88IRAK30.55934809
89IRAK40.55472024
90GRK70.55146866
91FGR0.53568508
92CHUK0.52363455
93STK160.51274930
94CDK60.50978716
95MAP3K110.50918692
96ERN10.48972540
97CDK90.48128140
98PRKAA20.48105228
99PAK20.47263056
100VRK10.46190333
101AURKB0.46023279
102SRPK10.43919509
103CDK11A0.43907695
104DAPK10.43710281
105MAP4K10.43354138
106PIK3CG0.42920079
107CSF1R0.42434226
108PAK40.40148480
109TSSK60.40014198
110FGFR40.39989269
111TYK20.39630715
112SYK0.39371220
113EIF2AK30.38586835
114MARK30.38432652
115CDK40.37402273
116RPS6KA50.37184033
117ADRBK20.37089679
118TGFBR20.36701788
119BMX0.36495597
120PRKACB0.36421207
121NEK20.34834474
122PDPK10.34420271
123CDK150.34170539
124MAP2K60.34020204
125MAPK40.33903664
126KIT0.33723094
127MARK20.32539536
128LYN0.32277180
129PLK20.32108383
130CAMK2G0.31859346
131CAMK10.31488505
132CLK10.31079105
133CHEK20.31021557
134TEC0.30007083
135AURKA0.29461332
136CAMKK20.29010550
137ROCK20.28977747
138TGFBR10.28923879
139CSNK2A10.28396123
140IKBKE0.28254281
141PIM10.28103763
142TBK10.27513412
143PRKACA0.27279423
144ITK0.26588559
145MAPKAPK30.24395022
146EIF2AK20.24391066
147PLK10.21609309
148PAK10.20617042
149LRRK20.19871709
150CCNB10.18031050
151PRKACG0.17889349

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.20506957
2Cardiac muscle contraction_Homo sapiens_hsa042604.33170097
3Oxidative phosphorylation_Homo sapiens_hsa001904.04186178
4Parkinsons disease_Homo sapiens_hsa050124.02742849
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.69276773
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.22034755
7Dilated cardiomyopathy_Homo sapiens_hsa054142.99071060
8Alzheimers disease_Homo sapiens_hsa050102.83616869
9Carbon metabolism_Homo sapiens_hsa012002.76843015
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.73438820
11Huntingtons disease_Homo sapiens_hsa050162.70437311
12Proteasome_Homo sapiens_hsa030502.47256128
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.25839630
14Propanoate metabolism_Homo sapiens_hsa006402.20513472
15Sulfur metabolism_Homo sapiens_hsa009202.14802849
16Staphylococcus aureus infection_Homo sapiens_hsa051502.14721234
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09748609
18Biosynthesis of amino acids_Homo sapiens_hsa012301.98724985
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.88913052
20Asthma_Homo sapiens_hsa053101.87305787
21Viral myocarditis_Homo sapiens_hsa054161.81131178
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.72857482
23Fatty acid degradation_Homo sapiens_hsa000711.72259898
24Rheumatoid arthritis_Homo sapiens_hsa053231.70401931
25RNA polymerase_Homo sapiens_hsa030201.67522282
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66768045
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.60419663
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56412196
29Pyruvate metabolism_Homo sapiens_hsa006201.54813189
30Galactose metabolism_Homo sapiens_hsa000521.52626293
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45787691
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43418697
33Ribosome_Homo sapiens_hsa030101.40786161
34Fructose and mannose metabolism_Homo sapiens_hsa000511.32511828
35Pentose phosphate pathway_Homo sapiens_hsa000301.32473198
36Base excision repair_Homo sapiens_hsa034101.30758394
37Complement and coagulation cascades_Homo sapiens_hsa046101.27080178
38DNA replication_Homo sapiens_hsa030301.25529050
39Allograft rejection_Homo sapiens_hsa053301.22856055
40Fatty acid metabolism_Homo sapiens_hsa012121.18892068
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.18850410
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16592058
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.15345699
44Pertussis_Homo sapiens_hsa051331.06701671
45Tuberculosis_Homo sapiens_hsa051521.05596535
46Starch and sucrose metabolism_Homo sapiens_hsa005001.01380624
47Osteoclast differentiation_Homo sapiens_hsa043800.98248276
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.96135103
49HIF-1 signaling pathway_Homo sapiens_hsa040660.95315006
50Mismatch repair_Homo sapiens_hsa034300.93078940
51Pyrimidine metabolism_Homo sapiens_hsa002400.92125968
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91034605
53Leishmaniasis_Homo sapiens_hsa051400.88249028
54Bladder cancer_Homo sapiens_hsa052190.87861995
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87715275
56Purine metabolism_Homo sapiens_hsa002300.86454258
57Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85379317
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84537964
59Autoimmune thyroid disease_Homo sapiens_hsa053200.83978155
60TNF signaling pathway_Homo sapiens_hsa046680.83546191
61Salmonella infection_Homo sapiens_hsa051320.81291147
62Homologous recombination_Homo sapiens_hsa034400.80763803
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79580709
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79255775
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77946271
66Graft-versus-host disease_Homo sapiens_hsa053320.77773127
67Fatty acid elongation_Homo sapiens_hsa000620.73862471
68Sphingolipid metabolism_Homo sapiens_hsa006000.73794936
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.73349361
70Non-homologous end-joining_Homo sapiens_hsa034500.72429930
71Collecting duct acid secretion_Homo sapiens_hsa049660.71913078
72Herpes simplex infection_Homo sapiens_hsa051680.70821113
73RNA transport_Homo sapiens_hsa030130.70362021
74Renin-angiotensin system_Homo sapiens_hsa046140.67849881
75Arginine and proline metabolism_Homo sapiens_hsa003300.67450816
76Malaria_Homo sapiens_hsa051440.66470559
77Vitamin B6 metabolism_Homo sapiens_hsa007500.66182480
78Spliceosome_Homo sapiens_hsa030400.64848163
79Prion diseases_Homo sapiens_hsa050200.63664034
80Metabolic pathways_Homo sapiens_hsa011000.60902547
81Type I diabetes mellitus_Homo sapiens_hsa049400.60007410
82Toxoplasmosis_Homo sapiens_hsa051450.58182144
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.57239430
84Glucagon signaling pathway_Homo sapiens_hsa049220.57026782
85Peroxisome_Homo sapiens_hsa041460.56776031
86Insulin resistance_Homo sapiens_hsa049310.55495379
87Nucleotide excision repair_Homo sapiens_hsa034200.54519911
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.54267605
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52162260
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50764451
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50716127
92RNA degradation_Homo sapiens_hsa030180.48558268
93PPAR signaling pathway_Homo sapiens_hsa033200.48538292
94Insulin signaling pathway_Homo sapiens_hsa049100.47542508
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46837134
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45720850
97Steroid biosynthesis_Homo sapiens_hsa001000.45333442
98Butanoate metabolism_Homo sapiens_hsa006500.44502158
99Basal transcription factors_Homo sapiens_hsa030220.39803475
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37928712
101Arginine biosynthesis_Homo sapiens_hsa002200.36525840
102Phenylalanine metabolism_Homo sapiens_hsa003600.36409262
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36297836
104Epstein-Barr virus infection_Homo sapiens_hsa051690.35266769
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34949558
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34840319
107Antigen processing and presentation_Homo sapiens_hsa046120.34585022
108Glutathione metabolism_Homo sapiens_hsa004800.33488153
109beta-Alanine metabolism_Homo sapiens_hsa004100.33001768
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32216024
111Vibrio cholerae infection_Homo sapiens_hsa051100.31024028
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24871249
113Regulation of autophagy_Homo sapiens_hsa041400.24059826
114AMPK signaling pathway_Homo sapiens_hsa041520.23917268
115Focal adhesion_Homo sapiens_hsa045100.22525846
116Primary immunodeficiency_Homo sapiens_hsa053400.22289669
117Legionellosis_Homo sapiens_hsa051340.21004882
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20966091
119Cell cycle_Homo sapiens_hsa041100.20008806
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.18948369
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.18444406
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15960486
123Sulfur relay system_Homo sapiens_hsa041220.13958316
124Folate biosynthesis_Homo sapiens_hsa007900.13820437
125Other glycan degradation_Homo sapiens_hsa005110.13760889
126Tight junction_Homo sapiens_hsa045300.13583913
127Lysosome_Homo sapiens_hsa041420.13507616
128Tryptophan metabolism_Homo sapiens_hsa003800.10683488
129Calcium signaling pathway_Homo sapiens_hsa040200.10545496
130Lysine degradation_Homo sapiens_hsa003100.09973822
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.09703487
132Oxytocin signaling pathway_Homo sapiens_hsa049210.07142738
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.05198390
134Apoptosis_Homo sapiens_hsa042100.04739661
135Systemic lupus erythematosus_Homo sapiens_hsa053220.04475093
136Protein export_Homo sapiens_hsa030600.04271320
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.04049172
138Phagosome_Homo sapiens_hsa041450.03596121
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03174851
140Tyrosine metabolism_Homo sapiens_hsa003500.02927505

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