NEUROD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)7.18843075
2Golgi transport vesicle coating (GO:0048200)6.28961859
3COPI coating of Golgi vesicle (GO:0048205)6.28961859
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)6.08820711
5photoreceptor cell development (GO:0042461)5.72761761
6eye photoreceptor cell development (GO:0042462)5.49146839
7photoreceptor cell maintenance (GO:0045494)5.30360561
8retinal rod cell development (GO:0046548)5.12024413
9regulation of rhodopsin mediated signaling pathway (GO:0022400)5.01742590
10rhodopsin mediated signaling pathway (GO:0016056)4.99819426
11retinal cone cell development (GO:0046549)4.60176992
12behavioral response to nicotine (GO:0035095)4.54163153
13detection of light stimulus involved in sensory perception (GO:0050962)4.37409684
14detection of light stimulus involved in visual perception (GO:0050908)4.37409684
15cellular ketone body metabolic process (GO:0046950)4.33455575
16GMP metabolic process (GO:0046037)4.27019377
17regulation of short-term neuronal synaptic plasticity (GO:0048172)4.26186051
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.24693085
19* endocrine pancreas development (GO:0031018)4.06594144
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.97274191
21regulation of synaptic vesicle exocytosis (GO:2000300)3.97249618
22positive regulation of insulin secretion (GO:0032024)3.96193410
23synaptic vesicle maturation (GO:0016188)3.92476419
24inositol phosphate catabolic process (GO:0071545)3.89741859
25dendritic spine morphogenesis (GO:0060997)3.87680798
26ketone body metabolic process (GO:1902224)3.80951818
27peptide hormone processing (GO:0016486)3.79004574
28regulation of hexokinase activity (GO:1903299)3.75114742
29regulation of glucokinase activity (GO:0033131)3.75114742
30photoreceptor cell differentiation (GO:0046530)3.71126725
31eye photoreceptor cell differentiation (GO:0001754)3.71126725
32regulation of calcium ion-dependent exocytosis (GO:0017158)3.69392813
33inositol phosphate dephosphorylation (GO:0046855)3.66861382
34phosphorylated carbohydrate dephosphorylation (GO:0046838)3.66861382
35cellular potassium ion homeostasis (GO:0030007)3.63243462
36detection of calcium ion (GO:0005513)3.61189006
37negative regulation of cytosolic calcium ion concentration (GO:0051481)3.60696258
38cerebellar Purkinje cell differentiation (GO:0021702)3.60358492
39positive regulation of vesicle fusion (GO:0031340)3.59957653
40chemosensory behavior (GO:0007635)3.58207966
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55711059
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.55310979
43membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.55033588
44regulation of glucocorticoid secretion (GO:2000849)3.54931282
45* regulation of insulin secretion (GO:0050796)3.53950884
46cerebellar granule cell differentiation (GO:0021707)3.53574264
47regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.53319808
48water-soluble vitamin biosynthetic process (GO:0042364)3.51784259
49regulation of synaptic vesicle transport (GO:1902803)3.51412337
50* insulin secretion (GO:0030073)3.49477660
51synaptic vesicle exocytosis (GO:0016079)3.46634611
52glycerophospholipid catabolic process (GO:0046475)3.42720974
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.38861717
54sensory perception of light stimulus (GO:0050953)3.33815398
55phototransduction (GO:0007602)3.32967771
56visual perception (GO:0007601)3.32313850
57COPII vesicle coating (GO:0048208)3.31421707
58detection of light stimulus (GO:0009583)3.31197967
59macroautophagy (GO:0016236)3.30207304
60positive regulation of gastrulation (GO:2000543)3.30143443
61* glandular epithelial cell differentiation (GO:0002067)3.29165804
62cell differentiation in hindbrain (GO:0021533)3.28840495
63locomotory exploration behavior (GO:0035641)3.25940356
64innervation (GO:0060384)3.24825514
65positive regulation of exocytosis (GO:0045921)3.22569678
66* regulation of peptide hormone secretion (GO:0090276)3.21876243
67membrane repolarization during action potential (GO:0086011)3.19054374
68positive regulation of synapse maturation (GO:0090129)3.18026112
69* regulation of peptide secretion (GO:0002791)3.18021306
70positive regulation of peptide hormone secretion (GO:0090277)3.17080428
71cell communication by electrical coupling (GO:0010644)3.16236113
72protein complex biogenesis (GO:0070271)3.14771357
73glandular epithelial cell development (GO:0002068)3.14361025
74positive regulation of peptide secretion (GO:0002793)3.13415434
75sodium ion export (GO:0071436)3.12107925
76regulation of vesicle fusion (GO:0031338)3.10822024
77protein maturation by protein folding (GO:0022417)3.09443688
78synaptic vesicle endocytosis (GO:0048488)3.09103546
79neuronal action potential propagation (GO:0019227)3.09056990
80detection of visible light (GO:0009584)3.06794612
81positive regulation of guanylate cyclase activity (GO:0031284)3.05689783
82brain morphogenesis (GO:0048854)3.02843592
83synaptic vesicle docking involved in exocytosis (GO:0016081)3.00549081
84nonmotile primary cilium assembly (GO:0035058)2.99780391
85type B pancreatic cell development (GO:0003323)2.98290423
86lactate metabolic process (GO:0006089)2.97958465
87retina development in camera-type eye (GO:0060041)2.97629547
88auditory receptor cell differentiation (GO:0042491)2.96574586
89negative regulation of hormone biosynthetic process (GO:0032353)2.96525601
90magnesium ion transport (GO:0015693)2.95963364
91protein retention in ER lumen (GO:0006621)2.95827085
92phototransduction, visible light (GO:0007603)2.95549718
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95471122
94presynaptic membrane organization (GO:0097090)2.93216238
95polyol catabolic process (GO:0046174)2.92835869
96vesicle coating (GO:0006901)2.91865452
97intra-Golgi vesicle-mediated transport (GO:0006891)2.90451173
98positive regulation of glycolytic process (GO:0045821)2.89149906
99presynaptic membrane assembly (GO:0097105)2.88998848
100neurotransmitter secretion (GO:0007269)2.88870292
101positive regulation of meiosis (GO:0045836)2.88664228
102axoneme assembly (GO:0035082)2.86675376
103exocrine pancreas development (GO:0031017)2.86434158
104potassium ion homeostasis (GO:0055075)2.84722811
105protein localization to synapse (GO:0035418)2.84234360
106positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83996667
107* regulation of hormone secretion (GO:0046883)2.82794659
108nephron tubule morphogenesis (GO:0072078)2.81696068
109nephron epithelium morphogenesis (GO:0072088)2.81696068
110* peptide hormone secretion (GO:0030072)2.81123214
111calcium ion import (GO:0070509)2.80878226
112regulation of corticosteroid hormone secretion (GO:2000846)2.80228639
113synaptic transmission, glutamatergic (GO:0035249)2.79109886
114cornea development in camera-type eye (GO:0061303)2.78869316
115negative regulation of protein oligomerization (GO:0032460)2.78722082
116neuron fate determination (GO:0048664)2.78572912
117kidney morphogenesis (GO:0060993)2.77823793
118negative regulation of catecholamine secretion (GO:0033604)2.76914508
119behavioral response to ethanol (GO:0048149)2.75584282
120positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.75113032
121cellular response to glucagon stimulus (GO:0071377)2.73466282
122regulation of autophagic vacuole assembly (GO:2000785)2.73288724
123mitochondrial respiratory chain complex assembly (GO:0033108)2.73109413
124protein-chromophore linkage (GO:0018298)2.71538631
125* peptide secretion (GO:0002790)2.71496096
126cerebellar Purkinje cell layer development (GO:0021680)2.71096422
127regulation of membrane repolarization (GO:0060306)2.69997289
128transmission of nerve impulse (GO:0019226)2.68945878
129neuron remodeling (GO:0016322)2.68020563
130fucose catabolic process (GO:0019317)2.67593904
131L-fucose metabolic process (GO:0042354)2.67593904
132L-fucose catabolic process (GO:0042355)2.67593904
133negative regulation of gluconeogenesis (GO:0045721)2.67270890
134potassium ion import (GO:0010107)2.67094236
135auditory behavior (GO:0031223)2.66645152
136regulation of guanylate cyclase activity (GO:0031282)2.66223102
137positive regulation of meiotic cell cycle (GO:0051446)2.65681163
138proline transport (GO:0015824)2.65447536
139regulation of neurotransmitter secretion (GO:0046928)2.64949407
140startle response (GO:0001964)2.64755078
141primitive streak formation (GO:0090009)2.64167022
142positive regulation of potassium ion transmembrane transport (GO:1901381)2.63892112
143neuronal action potential (GO:0019228)2.63744720
144regulation of heart rate by cardiac conduction (GO:0086091)2.63165124
145membrane depolarization during action potential (GO:0086010)2.63080039
146regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.62093829
147protein polyglutamylation (GO:0018095)2.61524032
148preassembly of GPI anchor in ER membrane (GO:0016254)2.60911907
149membrane repolarization (GO:0086009)2.59214911
150serotonin metabolic process (GO:0042428)2.58524046
151prostate gland growth (GO:0060736)2.58247429
152primary amino compound metabolic process (GO:1901160)2.57352586
153regulation of neurotransmitter uptake (GO:0051580)2.55802307
154reflex (GO:0060004)2.55119387
155neuromuscular process controlling posture (GO:0050884)2.54354435
156respiratory chain complex IV assembly (GO:0008535)2.52898922
157cytochrome complex assembly (GO:0017004)2.51990070
158neuron fate specification (GO:0048665)2.50499729
159gamma-aminobutyric acid transport (GO:0015812)2.50377707
160catecholamine transport (GO:0051937)2.49367187
161mitochondrial respiratory chain complex I assembly (GO:0032981)2.48871540
162NADH dehydrogenase complex assembly (GO:0010257)2.48871540
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.48871540
164action potential (GO:0001508)2.48795839
165epithelial cilium movement (GO:0003351)2.48497091
166calcium ion-dependent exocytosis (GO:0017156)2.47185897
167negative regulation of hormone metabolic process (GO:0032351)2.45835974
168multicellular organismal signaling (GO:0035637)2.44095825
169zinc ion homeostasis (GO:0055069)2.42881779
170renal tubule morphogenesis (GO:0061333)2.41797762
171adaptation of signaling pathway (GO:0023058)2.41276940
172regulation of cilium movement (GO:0003352)2.39539644
173negative regulation of dendrite development (GO:2000171)2.39350210
174dopamine transport (GO:0015872)2.39197942
175potassium ion transport (GO:0006813)2.38787467
176potassium ion transmembrane transport (GO:0071805)2.38784168
177cellular potassium ion transport (GO:0071804)2.38784168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.89875702
2DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.06814811
3* REST_21632747_ChIP-Seq_MESCs_Mouse2.88141433
4CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.67364759
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62083091
6GBX2_23144817_ChIP-Seq_PC3_Human2.56436554
7* REST_18959480_ChIP-ChIP_MESCs_Mouse2.50944308
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.48587226
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.34958799
10* EZH2_27294783_Chip-Seq_ESCs_Mouse2.34559943
11DROSHA_22980978_ChIP-Seq_HELA_Human2.31268139
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25137691
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24053808
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19073704
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16103965
16CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.00863547
17RARB_27405468_Chip-Seq_BRAIN_Mouse1.99383083
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.96888541
19IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96211979
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95478022
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95113890
22* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.93668106
23* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.89037897
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88748678
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.86219121
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85094450
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85094450
28EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83271682
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82399908
30TAF15_26573619_Chip-Seq_HEK293_Human1.74772440
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.72200394
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68890471
33FUS_26573619_Chip-Seq_HEK293_Human1.66717637
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64574427
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.62812145
36ZNF274_21170338_ChIP-Seq_K562_Hela1.58230638
37BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56617809
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51974106
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.50948252
40EWS_26573619_Chip-Seq_HEK293_Human1.49860793
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.48314397
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.47585118
43IGF1R_20145208_ChIP-Seq_DFB_Human1.42815163
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42501382
45VDR_22108803_ChIP-Seq_LS180_Human1.42213249
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40685851
47* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40537835
48* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40182086
49ER_23166858_ChIP-Seq_MCF-7_Human1.39223123
50STAT3_23295773_ChIP-Seq_U87_Human1.38703757
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.36887689
52AR_19668381_ChIP-Seq_PC3_Human1.36137997
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35847357
54* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.35532051
55* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35057654
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34278261
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.34091798
58* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33313041
59CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32233698
60* SMAD4_21799915_ChIP-Seq_A2780_Human1.30715831
61EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.28264011
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28260146
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27255417
64CBP_20019798_ChIP-Seq_JUKART_Human1.27255417
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27023321
66* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24564391
67KDM2B_26808549_Chip-Seq_K562_Human1.23390905
68* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22852076
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22619493
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22395875
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22021483
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21720502
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21462101
74TP53_22573176_ChIP-Seq_HFKS_Human1.19619087
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18264264
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.17273801
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16782837
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16201139
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15702394
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15477661
81RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15152642
82* P53_22387025_ChIP-Seq_ESCs_Mouse1.14595559
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.14395657
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13917937
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13608943
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13608943
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13260768
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12915088
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12796152
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12167390
91HTT_18923047_ChIP-ChIP_STHdh_Human1.11789289
92SMAD3_21741376_ChIP-Seq_ESCs_Human1.11692203
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.11421484
94* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10758369
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10508699
96NANOG_19829295_ChIP-Seq_ESCs_Human1.10495094
97SOX2_19829295_ChIP-Seq_ESCs_Human1.10495094
98TCF4_22108803_ChIP-Seq_LS180_Human1.09899872
99* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09362712
100TCF4_23295773_ChIP-Seq_U87_Human1.08273489
101REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07421302
102BCAT_22108803_ChIP-Seq_LS180_Human1.07416707
103EZH2_27294783_Chip-Seq_NPCs_Mouse1.06045742
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05732618
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.05643875
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05326355
107NFE2_27457419_Chip-Seq_LIVER_Mouse1.05134016
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02553972
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02036225
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.01471112
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00963022
112P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00856091
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00271818
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.00056278
115CBX2_27304074_Chip-Seq_ESCs_Mouse0.99781208
116SMAD4_21741376_ChIP-Seq_EPCs_Human0.99465655
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99444911
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.99303141
119FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99002955
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97287268
121* RING1B_27294783_Chip-Seq_ESCs_Mouse0.96832229
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.95983385
123RNF2_27304074_Chip-Seq_NSC_Mouse0.95667173
124CTCF_27219007_Chip-Seq_Bcells_Human0.95487078
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.94239712
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93968557
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92086239
128FLI1_21867929_ChIP-Seq_TH2_Mouse0.91394622
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90953942
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.89975237
131P300_19829295_ChIP-Seq_ESCs_Human0.88911639
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87950032
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87934295
134* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87746595
135ZFP281_18757296_ChIP-ChIP_E14_Mouse0.87357950
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.87306142
137DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87142498
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86981119
139* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86725216
140RUNX2_22187159_ChIP-Seq_PCA_Human0.86498226
141AR_25329375_ChIP-Seq_VCAP_Human0.86413931
142TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85041014
143NFIB_24661679_ChIP-Seq_LUNG_Mouse0.84131739
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83694860

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog4.63161424
2* MP0006072_abnormal_retinal_apoptosis4.24122351
3* MP0005253_abnormal_eye_physiology3.33206429
4MP0004043_abnormal_pH_regulation3.20952271
5MP0006292_abnormal_olfactory_placode3.19245202
6MP0010386_abnormal_urinary_bladder3.09438457
7MP0002638_abnormal_pupillary_reflex3.00632232
8MP0000013_abnormal_adipose_tissue2.96921774
9MP0003283_abnormal_digestive_organ2.86472971
10MP0009780_abnormal_chondrocyte_physiolo2.72780881
11MP0003183_abnormal_peptide_metabolism2.72620986
12MP0008877_abnormal_DNA_methylation2.70968615
13MP0002909_abnormal_adrenal_gland2.68228285
14MP0002877_abnormal_melanocyte_morpholog2.61087612
15MP0001502_abnormal_circadian_rhythm2.46274031
16MP0004270_analgesia2.32106792
17MP0002653_abnormal_ependyma_morphology2.25128486
18* MP0001944_abnormal_pancreas_morphology2.15446567
19MP0002693_abnormal_pancreas_physiology2.14746831
20MP0005423_abnormal_somatic_nervous2.13215175
21MP0002876_abnormal_thyroid_physiology2.08758286
22MP0003011_delayed_dark_adaptation2.07462300
23MP0004859_abnormal_synaptic_plasticity2.06654860
24MP0002234_abnormal_pharynx_morphology2.02962714
25MP0003635_abnormal_synaptic_transmissio1.97471000
26* MP0005195_abnormal_posterior_eye1.84576015
27MP0005645_abnormal_hypothalamus_physiol1.82574210
28MP0005379_endocrine/exocrine_gland_phen1.81254729
29MP0005394_taste/olfaction_phenotype1.78906486
30MP0005499_abnormal_olfactory_system1.78906486
31MP0002734_abnormal_mechanical_nocicepti1.75244302
32MP0001324_abnormal_eye_pigmentation1.74792666
33MP0009046_muscle_twitch1.73606492
34MP0002229_neurodegeneration1.72447697
35MP0008789_abnormal_olfactory_epithelium1.72143134
36MP0000678_abnormal_parathyroid_gland1.71701238
37MP0004145_abnormal_muscle_electrophysio1.70830073
38MP0001984_abnormal_olfaction1.68395424
39MP0000631_abnormal_neuroendocrine_gland1.63802865
40MP0003123_paternal_imprinting1.62201508
41MP0003195_calcinosis1.61416294
42* MP0005391_vision/eye_phenotype1.61414960
43MP0002160_abnormal_reproductive_system1.58137517
44MP0008569_lethality_at_weaning1.57059773
45MP0005646_abnormal_pituitary_gland1.53172560
46* MP0002272_abnormal_nervous_system1.52358528
47MP0003890_abnormal_embryonic-extraembry1.52201407
48MP0005187_abnormal_penis_morphology1.47999823
49MP0003121_genomic_imprinting1.47663844
50MP0000003_abnormal_adipose_tissue1.46832077
51MP0002837_dystrophic_cardiac_calcinosis1.43869428
52MP0000569_abnormal_digit_pigmentation1.43630690
53MP0001485_abnormal_pinna_reflex1.43303598
54MP0002067_abnormal_sensory_capabilities1.42638022
55MP0002063_abnormal_learning/memory/cond1.42116787
56MP0001905_abnormal_dopamine_level1.40918688
57MP0004133_heterotaxia1.40580954
58MP0002064_seizures1.39878061
59* MP0002184_abnormal_innervation1.38743661
60* MP0002882_abnormal_neuron_morphology1.36744914
61MP0002572_abnormal_emotion/affect_behav1.36086246
62MP0005389_reproductive_system_phenotype1.34554755
63MP0001986_abnormal_taste_sensitivity1.33186912
64MP0002090_abnormal_vision1.30234681
65* MP0002078_abnormal_glucose_homeostasis1.26397804
66MP0003122_maternal_imprinting1.26014351
67MP0009745_abnormal_behavioral_response1.22660077
68MP0000955_abnormal_spinal_cord1.22331929
69MP0008872_abnormal_physiological_respon1.20977295
70* MP0002752_abnormal_somatic_nervous1.20062544
71MP0000778_abnormal_nervous_system1.17131994
72MP0002557_abnormal_social/conspecific_i1.16345455
73* MP0005220_abnormal_exocrine_pancreas1.16169501
74MP0004019_abnormal_vitamin_homeostasis1.15486205
75MP0001756_abnormal_urination1.15166929
76MP0002822_catalepsy1.14656537
77MP0008961_abnormal_basal_metabolism1.13636229
78MP0003787_abnormal_imprinting1.13190844
79MP0002102_abnormal_ear_morphology1.11895027
80MP0001486_abnormal_startle_reflex1.09430406
81MP0005332_abnormal_amino_acid1.05320424
82MP0003879_abnormal_hair_cell1.04425098
83MP0010329_abnormal_lipoprotein_level1.04366010
84MP0002733_abnormal_thermal_nociception1.04318570
85* MP0004885_abnormal_endolymph1.00462460
86MP0001970_abnormal_pain_threshold0.99542742
87MP0000427_abnormal_hair_cycle0.98439931
88MP0005448_abnormal_energy_balance0.96621286
89* MP0003633_abnormal_nervous_system0.95310448
90MP0001919_abnormal_reproductive_system0.92907948
91MP0010234_abnormal_vibrissa_follicle0.91917338
92MP0001501_abnormal_sleep_pattern0.91332284
93MP0003953_abnormal_hormone_level0.91054777
94MP0005636_abnormal_mineral_homeostasis0.90478747
95MP0002736_abnormal_nociception_after0.90300351
96MP0003880_abnormal_central_pattern0.89977711
97MP0010030_abnormal_orbit_morphology0.89254814
98MP0002751_abnormal_autonomic_nervous0.88686733
99MP0004233_abnormal_muscle_weight0.87894564
100MP0000639_abnormal_adrenal_gland0.86367851
101MP0005084_abnormal_gallbladder_morpholo0.85743187
102MP0005386_behavior/neurological_phenoty0.85461201
103MP0004924_abnormal_behavior0.85461201
104MP0005257_abnormal_intraocular_pressure0.85391003
105* MP0002066_abnormal_motor_capabilities/c0.84598092
106MP0004147_increased_porphyrin_level0.84431534
107MP0002139_abnormal_hepatobiliary_system0.84387912
108MP0001529_abnormal_vocalization0.83330520
109* MP0004811_abnormal_neuron_physiology0.83159607
110MP0002069_abnormal_eating/drinking_beha0.82565789
111MP0004134_abnormal_chest_morphology0.82102030
112MP0006276_abnormal_autonomic_nervous0.81933193
113MP0003119_abnormal_digestive_system0.81561942
114MP0001968_abnormal_touch/_nociception0.81322188
115MP0001440_abnormal_grooming_behavior0.81074313
116MP0002928_abnormal_bile_duct0.80602673
117MP0004085_abnormal_heartbeat0.80368792
118MP0002938_white_spotting0.79770585
119MP0000230_abnormal_systemic_arterial0.78505467
120* MP0002152_abnormal_brain_morphology0.78180100
121MP0002735_abnormal_chemical_nociception0.78127830
122MP0003172_abnormal_lysosome_physiology0.77521385
123MP0000462_abnormal_digestive_system0.74006899
124MP0001765_abnormal_ion_homeostasis0.73383753
125MP0001299_abnormal_eye_distance/0.73012924
126MP0004142_abnormal_muscle_tone0.70273502
127* MP0003634_abnormal_glial_cell0.70048557
128MP0005535_abnormal_body_temperature0.67902407
129MP0002896_abnormal_bone_mineralization0.64603071
130MP0004264_abnormal_extraembryonic_tissu0.63566318
131MP0004742_abnormal_vestibular_system0.61720666
132MP0005248_abnormal_Harderian_gland0.60195259
133MP0002163_abnormal_gland_morphology0.58650545

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)7.15812956
2Abnormal rod and cone electroretinograms (HP:0008323)6.97217500
3Congenital stationary night blindness (HP:0007642)6.73080907
4Bony spicule pigmentary retinopathy (HP:0007737)6.01914218
5Central scotoma (HP:0000603)5.71343867
6Chorioretinal atrophy (HP:0000533)4.83938750
7Pendular nystagmus (HP:0012043)4.82530656
8Hyperinsulinemic hypoglycemia (HP:0000825)4.72130799
9Abnormality of macular pigmentation (HP:0008002)4.58639261
10Hypoglycemic seizures (HP:0002173)4.47531371
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.44815465
12Abolished electroretinogram (ERG) (HP:0000550)4.40015626
13Posterior subcapsular cataract (HP:0007787)4.24996083
14Type II diabetes mellitus (HP:0005978)4.24565023
15Scotoma (HP:0000575)4.24002354
16Attenuation of retinal blood vessels (HP:0007843)4.13254077
17Decreased central vision (HP:0007663)4.01495349
18Symptomatic seizures (HP:0011145)3.98239912
19Pigmentary retinal degeneration (HP:0001146)3.94753726
20Visual hallucinations (HP:0002367)3.70009979
21Constricted visual fields (HP:0001133)3.50333391
22Severe visual impairment (HP:0001141)3.48939010
23Hypoglycemic coma (HP:0001325)3.24118347
24Dyschromatopsia (HP:0007641)3.19247579
25Hyperglycemia (HP:0003074)3.15224826
26Photophobia (HP:0000613)3.10291725
27Increased corneal curvature (HP:0100692)3.08775329
28Keratoconus (HP:0000563)3.08775329
29Agitation (HP:0000713)2.99247524
30Abnormality of calcium-phosphate metabolism (HP:0100530)2.95521387
31Increased circulating renin level (HP:0000848)2.95378895
32Insulin-resistant diabetes mellitus (HP:0000831)2.91684136
33Retinal atrophy (HP:0001105)2.89662299
34Hypothermia (HP:0002045)2.86402014
35Cone-rod dystrophy (HP:0000548)2.86236529
36Progressive cerebellar ataxia (HP:0002073)2.82853524
37Decreased circulating renin level (HP:0003351)2.82045345
38Methylmalonic acidemia (HP:0002912)2.80345697
39Ketosis (HP:0001946)2.72493107
40Retinitis pigmentosa (HP:0000510)2.72434666
41Nephronophthisis (HP:0000090)2.71815411
42Abnormality of the pancreatic islet cells (HP:0006476)2.69489352
43Abnormality of endocrine pancreas physiology (HP:0012093)2.69489352
44Hypomagnesemia (HP:0002917)2.66916488
45Ketoacidosis (HP:0001993)2.66706057
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.66312289
47Hypoplasia of the fovea (HP:0007750)2.66312289
48Polydipsia (HP:0001959)2.66072145
49Abnormal drinking behavior (HP:0030082)2.66072145
50Abnormality of the fovea (HP:0000493)2.65610560
51Macular degeneration (HP:0000608)2.64135549
52Abnormality of midbrain morphology (HP:0002418)2.62764988
53Molar tooth sign on MRI (HP:0002419)2.62764988
54Pancreatic islet-cell hyperplasia (HP:0004510)2.52192971
55Abnormality of the renal cortex (HP:0011035)2.51390164
56Conjunctival hamartoma (HP:0100780)2.48537902
57Epileptic encephalopathy (HP:0200134)2.46082093
58Large for gestational age (HP:0001520)2.41197997
59Hamartoma of the eye (HP:0010568)2.40436361
60Impaired smooth pursuit (HP:0007772)2.39728850
61Abnormality of vitamin B metabolism (HP:0004340)2.37237153
62Congenital malformation of the right heart (HP:0011723)2.35883944
63Double outlet right ventricle (HP:0001719)2.35883944
64Progressive macrocephaly (HP:0004481)2.35730652
65Gait imbalance (HP:0002141)2.34651384
66Abnormal pancreas size (HP:0012094)2.32689475
67EEG with generalized epileptiform discharges (HP:0011198)2.31420220
68Enlarged penis (HP:0000040)2.29824137
69Action tremor (HP:0002345)2.27577106
70Congenital primary aphakia (HP:0007707)2.26930932
71Furrowed tongue (HP:0000221)2.26202689
72Epileptiform EEG discharges (HP:0011182)2.25232888
73Vitreoretinal degeneration (HP:0000655)2.23695988
74Hyperventilation (HP:0002883)2.22547350
75Subcapsular cataract (HP:0000523)2.22470114
76Abnormality of the renal medulla (HP:0100957)2.21641106
77Hemiparesis (HP:0001269)2.18578425
78Neoplasm of the adrenal cortex (HP:0100641)2.17292428
79Progressive visual loss (HP:0000529)2.16783692
80Medial flaring of the eyebrow (HP:0010747)2.16143490
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.13447630
82Choroideremia (HP:0001139)2.13179596
83Late onset (HP:0003584)2.12833051
84Hypsarrhythmia (HP:0002521)2.12618475
85Polyphagia (HP:0002591)2.12070320
86Renal cortical cysts (HP:0000803)2.10968266
87Hyperthyroidism (HP:0000836)2.10155035
88Focal seizures (HP:0007359)2.09180622
89Congenital sensorineural hearing impairment (HP:0008527)2.08646417
90Methylmalonic aciduria (HP:0012120)2.08076384
91Nephrogenic diabetes insipidus (HP:0009806)2.06755754
92Abnormality of ocular smooth pursuit (HP:0000617)2.06597551
93Hematochezia (HP:0002573)2.06569359
94Hypokalemia (HP:0002900)2.03440489
95Acute necrotizing encephalopathy (HP:0006965)2.03224315
96Intestinal atresia (HP:0011100)2.01684455
97Febrile seizures (HP:0002373)1.99170688
98Adrenal hypoplasia (HP:0000835)1.98862968
993-Methylglutaconic aciduria (HP:0003535)1.97242088
100Truncal ataxia (HP:0002078)1.96993408
101Type II lissencephaly (HP:0007260)1.96319612
102Broad-based gait (HP:0002136)1.95784442
103Neoplasm of the heart (HP:0100544)1.95520353
104Polyuria (HP:0000103)1.95109971
105Abnormality of magnesium homeostasis (HP:0004921)1.94632029
106Hepatic necrosis (HP:0002605)1.94050206
107Genetic anticipation (HP:0003743)1.93879461
108Depression (HP:0000716)1.93469882
109Mitochondrial inheritance (HP:0001427)1.92317823
110Cystic liver disease (HP:0006706)1.91421499
111Pancreatic fibrosis (HP:0100732)1.90848459
112Absence seizures (HP:0002121)1.88842670
113Dysdiadochokinesis (HP:0002075)1.88545140
114Thyroiditis (HP:0100646)1.87029334
115Ventricular fibrillation (HP:0001663)1.85916364
116Atonic seizures (HP:0010819)1.85753336
117True hermaphroditism (HP:0010459)1.85363284
118Aqueductal stenosis (HP:0002410)1.85284439
119Aplasia/Hypoplasia of the macula (HP:0008059)1.85279347
120Pheochromocytoma (HP:0002666)1.84649646
121Osteomalacia (HP:0002749)1.83843521
122Genital tract atresia (HP:0001827)1.82211195
123Restlessness (HP:0000711)1.81509197
124Hyperkalemia (HP:0002153)1.80875958
125Aplasia/hypoplasia of the uterus (HP:0008684)1.80298130
126Hyperphosphatemia (HP:0002905)1.80255260
127Generalized tonic-clonic seizures (HP:0002069)1.78592250
128Dialeptic seizures (HP:0011146)1.78500264
129Goiter (HP:0000853)1.78496143
130Abnormality of vitamin metabolism (HP:0100508)1.77461196
131Aplasia/Hypoplasia of the lens (HP:0008063)1.77343206
132Aplasia/Hypoplasia of the spleen (HP:0010451)1.76750939
133Aplasia/Hypoplasia affecting the retina (HP:0008061)1.76633180
134Intention tremor (HP:0002080)1.76103707
135Hyperparathyroidism (HP:0000843)1.76058172
136Asplenia (HP:0001746)1.75849451
137Macroorchidism (HP:0000053)1.75569224
138Postural tremor (HP:0002174)1.75443162
139Abnormal albumin level (HP:0012116)1.75378005
140Hypoalbuminemia (HP:0003073)1.75378005
141Muscular hypotonia of the trunk (HP:0008936)1.74670744
142Anxiety (HP:0000739)1.74653022
143Abnormal eating behavior (HP:0100738)1.74477793
144Gaze-evoked nystagmus (HP:0000640)1.74341844
145Anteriorly placed anus (HP:0001545)1.71538524
146Menstrual irregularities (HP:0000858)1.70410782
147Abnormality of potassium homeostasis (HP:0011042)1.69821836
148Dysautonomia (HP:0002459)1.69202192
149Focal motor seizures (HP:0011153)1.66197562
150Abnormality of renin-angiotensin system (HP:0000847)1.66177550
151Supranuclear gaze palsy (HP:0000605)1.65156097
152Hypercortisolism (HP:0001578)1.63662131
153Pancreatic cysts (HP:0001737)1.62659726
154Poor coordination (HP:0002370)1.60920762
155Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.60512646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.70948222
2MAPK154.07939314
3PASK3.59333035
4WNK33.19189960
5FGFR23.03204269
6HIPK22.82521452
7CAMKK22.74820655
8PRKD32.58123881
9NTRK32.56583601
10ADRBK22.52953356
11MAP4K22.49734483
12IRAK22.29455298
13PHKG22.17980915
14PHKG12.17980915
15MAP3K22.16468149
16MAP2K61.76129081
17WNK11.71997787
18UHMK11.71757094
19MARK11.67610716
20SGK4941.60602238
21SGK2231.60602238
22RIPK11.55501385
23WNK41.54905433
24ERBB31.53097744
25BRD41.52977125
26AKT31.52873220
27BMPR1B1.50219593
28TAOK31.49747288
29GRK11.38241000
30CAMKK11.36798211
31TRIM281.36213523
32CDC42BPA1.35644051
33DYRK1B1.33510107
34PLK21.33071973
35EPHA31.31640694
36TLK11.31272764
37DYRK1A1.31094925
38SGK21.30056816
39FRK1.29596613
40PAK61.28611920
41NLK1.23580036
42PINK11.23470187
43IRAK11.21793439
44MAP3K41.21180400
45PRKCH1.15898072
46NTRK11.13546320
47ACVR1B1.11407428
48STK391.07901442
49OXSR11.07463622
50PRPF4B1.07409217
51MST41.04633310
52BMPR21.00211500
53STK110.99655652
54CSNK1G10.99012004
55PTK60.96277548
56MINK10.96092951
57PTK20.95259534
58CSNK1G20.92416397
59FGFR30.91845005
60PAK30.91717387
61STK380.91161769
62NUAK10.90922051
63CAMK1G0.89115862
64PNCK0.89113999
65SGK30.85755648
66CAMK2D0.85604469
67PRKCG0.85578467
68MAP2K70.84906479
69NTRK20.81832640
70DYRK20.81314243
71CSNK1G30.80928730
72CDK50.80578334
73SCYL20.79798451
74STK38L0.78287846
75CDK30.77296748
76PIK3CG0.76872702
77SIK20.75973831
78EPHA40.75756430
79PRKAA10.75484235
80STK30.75205225
81ZAK0.74607978
82PTK2B0.73863639
83PRKD20.68348264
84ERN10.67697550
85PDGFRA0.65939226
86STK160.64944200
87MARK20.63443631
88MAPK130.63178416
89SGK10.63018617
90TNIK0.61885545
91MAP3K10.60700991
92ERBB20.58529412
93DAPK20.58305113
94RET0.58272884
95SIK10.56701448
96FLT30.55297131
97CAMK2B0.55005374
98PRKCZ0.54246487
99TAOK10.54119162
100KSR10.53909154
101RPS6KA20.53889108
102MAP3K100.53515068
103GRK50.52462528
104PRKCE0.52174019
105MAP3K90.51940483
106CASK0.51178321
107TRPM70.50973962
108RPS6KA30.50795334
109BCKDK0.50709411
110CSNK1A1L0.50280082
111MAPK100.50007766
112CAMK10.49790884
113TIE10.49780566
114PRKDC0.49034319
115NEK60.48892139
116CDK190.48861937
117ADRBK10.47949463
118RPS6KB10.46119921
119LATS10.45451000
120CAMK40.44666606
121MAP2K40.44314711
122PRKACA0.43857059
123CAMK2A0.43554139
124BRAF0.42865840
125FER0.42164441
126MAP2K20.42015473
127PRKCI0.41365763
128PRKG10.41113330
129KSR20.41109240
130PRKCA0.40784688
131PRKCB0.39928007
132PRKACG0.39543138
133* GSK3B0.39464701
134ALK0.38137213
135CSNK1A10.37812806
136* MAPK140.37276645
137PRKAA20.36569169
138CSNK1D0.36144160
139SIK30.35546057
140TXK0.35543737
141MKNK20.34927357
142GRK70.33423046
143PRKCQ0.32079451
144TNK20.31837676

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.51541914
2* Maturity onset diabetes of the young_Homo sapiens_hsa049505.38719304
3Insulin secretion_Homo sapiens_hsa049113.18714734
4Protein export_Homo sapiens_hsa030602.72148051
5Synaptic vesicle cycle_Homo sapiens_hsa047212.69300488
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.63970261
7Butanoate metabolism_Homo sapiens_hsa006502.50231946
8GABAergic synapse_Homo sapiens_hsa047272.34936914
9Nicotine addiction_Homo sapiens_hsa050332.27784947
10Circadian entrainment_Homo sapiens_hsa047132.27514808
11Oxidative phosphorylation_Homo sapiens_hsa001902.21618270
12Type II diabetes mellitus_Homo sapiens_hsa049302.17162221
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10843892
14Taste transduction_Homo sapiens_hsa047422.04087670
15Glutamatergic synapse_Homo sapiens_hsa047241.91724110
16Morphine addiction_Homo sapiens_hsa050321.91549183
17Long-term potentiation_Homo sapiens_hsa047201.89144673
18Circadian rhythm_Homo sapiens_hsa047101.87949532
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86094730
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.81774619
21Amphetamine addiction_Homo sapiens_hsa050311.78401158
22Dopaminergic synapse_Homo sapiens_hsa047281.75978364
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73250966
24Cholinergic synapse_Homo sapiens_hsa047251.63750484
25Vibrio cholerae infection_Homo sapiens_hsa051101.60007367
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.55262717
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54782071
28Cocaine addiction_Homo sapiens_hsa050301.53610357
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.50937658
30Serotonergic synapse_Homo sapiens_hsa047261.40413681
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39874066
32Tryptophan metabolism_Homo sapiens_hsa003801.39800290
33Parkinsons disease_Homo sapiens_hsa050121.34084743
34Olfactory transduction_Homo sapiens_hsa047401.33178255
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30476768
36Linoleic acid metabolism_Homo sapiens_hsa005911.24964409
37Long-term depression_Homo sapiens_hsa047301.23360712
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22219543
39Sulfur metabolism_Homo sapiens_hsa009201.19265601
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18569483
41Ether lipid metabolism_Homo sapiens_hsa005651.18179164
42Pancreatic secretion_Homo sapiens_hsa049721.14329689
43Nitrogen metabolism_Homo sapiens_hsa009101.13865453
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13849118
45Alzheimers disease_Homo sapiens_hsa050101.13433301
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12864030
47Folate biosynthesis_Homo sapiens_hsa007901.12097775
48Peroxisome_Homo sapiens_hsa041461.11146497
49Salivary secretion_Homo sapiens_hsa049701.09008454
50Thyroid hormone synthesis_Homo sapiens_hsa049181.07848932
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06779555
52Type I diabetes mellitus_Homo sapiens_hsa049401.03139020
53Renin secretion_Homo sapiens_hsa049241.02922531
54Glucagon signaling pathway_Homo sapiens_hsa049221.02780997
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99827925
56Collecting duct acid secretion_Homo sapiens_hsa049660.99074045
57Dorso-ventral axis formation_Homo sapiens_hsa043200.98238072
58N-Glycan biosynthesis_Homo sapiens_hsa005100.98152184
59Gastric acid secretion_Homo sapiens_hsa049710.97510226
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95458981
61cAMP signaling pathway_Homo sapiens_hsa040240.95087085
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91833661
63Vitamin B6 metabolism_Homo sapiens_hsa007500.91678540
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87013701
65Oxytocin signaling pathway_Homo sapiens_hsa049210.86647636
66Regulation of autophagy_Homo sapiens_hsa041400.86314829
67Fatty acid elongation_Homo sapiens_hsa000620.86143642
68Estrogen signaling pathway_Homo sapiens_hsa049150.86122702
69Retinol metabolism_Homo sapiens_hsa008300.84826897
70Propanoate metabolism_Homo sapiens_hsa006400.84160005
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82016943
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.80420230
73Ovarian steroidogenesis_Homo sapiens_hsa049130.79274849
74Inositol phosphate metabolism_Homo sapiens_hsa005620.76687726
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76218450
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.76050038
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75517322
78Alcoholism_Homo sapiens_hsa050340.72112264
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71081327
80Lysosome_Homo sapiens_hsa041420.70400848
81Chemical carcinogenesis_Homo sapiens_hsa052040.70272892
82Huntingtons disease_Homo sapiens_hsa050160.69797471
83mTOR signaling pathway_Homo sapiens_hsa041500.69079544
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68701328
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67910938
86Calcium signaling pathway_Homo sapiens_hsa040200.65657307
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.64738407
88ABC transporters_Homo sapiens_hsa020100.62413979
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.60316512
90Caffeine metabolism_Homo sapiens_hsa002320.59315576
91beta-Alanine metabolism_Homo sapiens_hsa004100.59003202
92Gap junction_Homo sapiens_hsa045400.58896527
93GnRH signaling pathway_Homo sapiens_hsa049120.58634552
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56774725
95Insulin resistance_Homo sapiens_hsa049310.56420259
96Fatty acid metabolism_Homo sapiens_hsa012120.54400379
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53670109
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53568521
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52606250
100Arachidonic acid metabolism_Homo sapiens_hsa005900.52119009
101Fatty acid degradation_Homo sapiens_hsa000710.51917977
102Prolactin signaling pathway_Homo sapiens_hsa049170.51878060
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51015721
104Basal transcription factors_Homo sapiens_hsa030220.50813581
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.49022493
106Fructose and mannose metabolism_Homo sapiens_hsa000510.48791747
107Selenocompound metabolism_Homo sapiens_hsa004500.48052446
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45675011
109Metabolic pathways_Homo sapiens_hsa011000.45575492
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44747874
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44424354
112Melanogenesis_Homo sapiens_hsa049160.41464209
113RNA degradation_Homo sapiens_hsa030180.41284785
114Insulin signaling pathway_Homo sapiens_hsa049100.41049009
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40801687
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.40801203
117RNA polymerase_Homo sapiens_hsa030200.40796428
118Lysine degradation_Homo sapiens_hsa003100.40695321
119AMPK signaling pathway_Homo sapiens_hsa041520.39289431
120Cardiac muscle contraction_Homo sapiens_hsa042600.39131374
121Galactose metabolism_Homo sapiens_hsa000520.38212232
122Prion diseases_Homo sapiens_hsa050200.37813757
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37709455
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37345648
125Glycerolipid metabolism_Homo sapiens_hsa005610.35815280
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34987520
127Endometrial cancer_Homo sapiens_hsa052130.32506276
128Axon guidance_Homo sapiens_hsa043600.32438636
129Glioma_Homo sapiens_hsa052140.31823870
130Dilated cardiomyopathy_Homo sapiens_hsa054140.31182468
131Choline metabolism in cancer_Homo sapiens_hsa052310.29803263
132MAPK signaling pathway_Homo sapiens_hsa040100.28774922
133ErbB signaling pathway_Homo sapiens_hsa040120.27191165
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26998344
135Bile secretion_Homo sapiens_hsa049760.26812378
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26772063
137Phospholipase D signaling pathway_Homo sapiens_hsa040720.25996309
138Sphingolipid metabolism_Homo sapiens_hsa006000.25691379
139Hedgehog signaling pathway_Homo sapiens_hsa043400.25235707
140Mineral absorption_Homo sapiens_hsa049780.25224139
141Oocyte meiosis_Homo sapiens_hsa041140.25125420
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.24856525
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.23572546
144Wnt signaling pathway_Homo sapiens_hsa043100.23433979

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »