NEUROD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.93322390
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.92904758
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.83307128
4vocalization behavior (GO:0071625)5.83272386
5locomotory exploration behavior (GO:0035641)5.77908360
6ionotropic glutamate receptor signaling pathway (GO:0035235)5.62538097
7behavioral response to nicotine (GO:0035095)5.42961482
8protein localization to synapse (GO:0035418)5.34018428
9regulation of glutamate receptor signaling pathway (GO:1900449)5.32157498
10synaptic vesicle exocytosis (GO:0016079)5.28627156
11glutamate receptor signaling pathway (GO:0007215)5.25845804
12synaptic vesicle maturation (GO:0016188)5.24404329
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.16525611
14membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.06023247
15glutamate secretion (GO:0014047)4.98195426
16synaptic transmission, glutamatergic (GO:0035249)4.96433678
17exploration behavior (GO:0035640)4.93436906
18synaptic vesicle docking involved in exocytosis (GO:0016081)4.82702960
19regulation of synaptic vesicle exocytosis (GO:2000300)4.78733500
20neuron cell-cell adhesion (GO:0007158)4.72353342
21regulation of neuronal synaptic plasticity (GO:0048168)4.57199379
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.55257690
23membrane repolarization during action potential (GO:0086011)4.54697959
24neuron recognition (GO:0008038)4.48560555
25neuron-neuron synaptic transmission (GO:0007270)4.41623692
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40886648
27layer formation in cerebral cortex (GO:0021819)4.40546446
28dendritic spine morphogenesis (GO:0060997)4.37985540
29parturition (GO:0007567)4.37674988
30regulation of synaptic vesicle transport (GO:1902803)4.36988473
31neuronal action potential propagation (GO:0019227)4.33510127
32G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.29125862
33axonal fasciculation (GO:0007413)4.28427122
34regulation of excitatory postsynaptic membrane potential (GO:0060079)4.22143465
35neurotransmitter-gated ion channel clustering (GO:0072578)4.20449560
36long-term memory (GO:0007616)4.14736332
37central nervous system projection neuron axonogenesis (GO:0021952)4.12011925
38regulation of dendritic spine morphogenesis (GO:0061001)4.11834704
39positive regulation of dendritic spine morphogenesis (GO:0061003)4.09491114
40gamma-aminobutyric acid signaling pathway (GO:0007214)4.09009193
41serotonin metabolic process (GO:0042428)4.06834382
42cerebellar granule cell differentiation (GO:0021707)4.06176983
43synaptic vesicle endocytosis (GO:0048488)4.04967078
44regulation of synapse structural plasticity (GO:0051823)4.04243646
45regulation of membrane repolarization (GO:0060306)3.96959651
46regulation of postsynaptic membrane potential (GO:0060078)3.96202459
47positive regulation of potassium ion transmembrane transport (GO:1901381)3.95539686
48membrane repolarization (GO:0086009)3.95083665
49postsynaptic membrane organization (GO:0001941)3.88922495
50primary amino compound metabolic process (GO:1901160)3.88450337
51positive regulation of membrane potential (GO:0045838)3.88017914
52neurotransmitter secretion (GO:0007269)3.87766345
53dendritic spine organization (GO:0097061)3.83712813
54* regulation of synaptic plasticity (GO:0048167)3.81585005
55dendrite morphogenesis (GO:0048813)3.78241472
56* positive regulation of synapse maturation (GO:0090129)3.76628047
57gamma-aminobutyric acid transport (GO:0015812)3.69030892
58proline transport (GO:0015824)3.66599049
59potassium ion import (GO:0010107)3.66354250
60long-term synaptic potentiation (GO:0060291)3.65842352
61transmission of nerve impulse (GO:0019226)3.65213672
62positive regulation of dendritic spine development (GO:0060999)3.65144670
63cellular potassium ion homeostasis (GO:0030007)3.62272716
64presynaptic membrane organization (GO:0097090)3.57441941
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.54449639
66regulation of dendritic spine development (GO:0060998)3.54428474
67presynaptic membrane assembly (GO:0097105)3.54270215
68positive regulation of neurotransmitter secretion (GO:0001956)3.52901079
69innervation (GO:0060384)3.51235006
70regulation of neurotransmitter secretion (GO:0046928)3.45702616
71cell migration in hindbrain (GO:0021535)3.40338404
72regulation of vesicle fusion (GO:0031338)3.39671825
73cerebellar Purkinje cell differentiation (GO:0021702)3.34792906
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34137063
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.33195878
76negative regulation of appetite (GO:0032099)3.31499092
77negative regulation of response to food (GO:0032096)3.31499092
78central nervous system neuron axonogenesis (GO:0021955)3.31202950
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.29137603
80long term synaptic depression (GO:0060292)3.26627407
81membrane depolarization (GO:0051899)3.26560685
82cell communication by electrical coupling (GO:0010644)3.22965142
83neuromuscular process controlling balance (GO:0050885)3.21051579
84cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20572496
85cochlea development (GO:0090102)3.20362235
86potassium ion homeostasis (GO:0055075)3.18974365
87neurotransmitter transport (GO:0006836)3.18463159
88central nervous system myelination (GO:0022010)3.18266768
89axon ensheathment in central nervous system (GO:0032291)3.18266768
90* behavioral defense response (GO:0002209)3.17856756
91* behavioral fear response (GO:0001662)3.17856756
92sodium ion export (GO:0071436)3.17651395
93multicellular organismal signaling (GO:0035637)3.17592936
94regulation of DNA endoreduplication (GO:0032875)3.17459055
95* learning (GO:0007612)3.17436046
96regulation of potassium ion transmembrane transport (GO:1901379)3.13893620
97mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11613081
98mitochondrial respiratory chain complex I assembly (GO:0032981)3.11613081
99NADH dehydrogenase complex assembly (GO:0010257)3.11613081
100regulation of heart rate by cardiac conduction (GO:0086091)3.08884546
101response to histamine (GO:0034776)3.08031074
102chemosensory behavior (GO:0007635)3.07439569
103cerebral cortex radially oriented cell migration (GO:0021799)3.07030294
104synapse assembly (GO:0007416)3.06735280
105* regulation of synaptic transmission (GO:0050804)3.06496027
106regulation of skeletal muscle contraction (GO:0014819)3.06449122
107positive regulation of meiosis (GO:0045836)3.06122706
108response to pheromone (GO:0019236)3.05622848
109regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05526284
110regulation of neurotransmitter transport (GO:0051588)3.05455145
111* fear response (GO:0042596)3.02238414
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02100765
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01032296
114auditory behavior (GO:0031223)2.98500874
115protein complex biogenesis (GO:0070271)2.97950536
116synaptic transmission (GO:0007268)2.97385852
117positive regulation of fibroblast migration (GO:0010763)2.97329571
118sulfation (GO:0051923)2.96978620
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96014760
120cardiac conduction (GO:0061337)2.95927616
121ovulation cycle (GO:0042698)2.95807351
122neuromuscular synaptic transmission (GO:0007274)2.95747818
123cell proliferation in forebrain (GO:0021846)2.95018147
124membrane depolarization during action potential (GO:0086010)2.94777977
125cellular sodium ion homeostasis (GO:0006883)2.93739030
126positive regulation of neurotransmitter transport (GO:0051590)2.92414872
127regulation of neurotransmitter levels (GO:0001505)2.91491693
128magnesium ion transport (GO:0015693)2.91145678
129regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.90348030
130activation of protein kinase A activity (GO:0034199)2.90143088
131regulation of female receptivity (GO:0045924)2.88921709
132intraspecies interaction between organisms (GO:0051703)2.88224475
133regulation of mesoderm development (GO:2000380)2.87908283
134positive regulation of meiotic cell cycle (GO:0051446)2.84650923
135protein polyglutamylation (GO:0018095)2.82115306
136water-soluble vitamin biosynthetic process (GO:0042364)2.81821277
137DNA deamination (GO:0045006)2.80146903
138action potential (GO:0001508)2.75191986
139neuronal action potential (GO:0019228)2.73771409
140indole-containing compound metabolic process (GO:0042430)2.73624087
141positive regulation of potassium ion transport (GO:0043268)2.65747239
142somite development (GO:0061053)2.65148014
143female mating behavior (GO:0060180)2.64055827
144cellular potassium ion transport (GO:0071804)2.63808168
145potassium ion transmembrane transport (GO:0071805)2.63808168
146mitochondrial respiratory chain complex assembly (GO:0033108)2.63793766
147positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.62920444
148mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.60337577
149startle response (GO:0001964)2.59792687
150regulation of response to food (GO:0032095)2.57654525
151regulation of glomerulus development (GO:0090192)2.57140731
152regulation of calcium ion-dependent exocytosis (GO:0017158)2.55218931
153detection of light stimulus involved in visual perception (GO:0050908)2.53004197
154detection of light stimulus involved in sensory perception (GO:0050962)2.53004197
155cellular response to ATP (GO:0071318)2.52347121
156negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52089674
157spinal cord development (GO:0021510)2.51333743
158indolalkylamine metabolic process (GO:0006586)2.50914221
159retinal ganglion cell axon guidance (GO:0031290)2.50134097

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.73892292
2GBX2_23144817_ChIP-Seq_PC3_Human3.81533289
3* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.26393338
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.20557191
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11401920
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81936034
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81936034
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.79372854
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.78469274
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73985539
11* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71305054
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68563988
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.66496971
14DROSHA_22980978_ChIP-Seq_HELA_Human2.56352977
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51265357
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.48971726
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48240376
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46678903
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.41428444
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.41346780
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.40550893
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.33156664
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28210834
24* REST_18959480_ChIP-ChIP_MESCs_Mouse2.17532997
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16372897
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00569125
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99343103
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83716264
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81901519
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81728824
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80955173
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79932984
33AR_21572438_ChIP-Seq_LNCaP_Human1.79049439
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78337309
35* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77869304
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72418264
37SMAD4_21799915_ChIP-Seq_A2780_Human1.62841103
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58278635
39ZNF274_21170338_ChIP-Seq_K562_Hela1.55786213
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53263633
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53190369
42* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44354184
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.43212579
44* P300_19829295_ChIP-Seq_ESCs_Human1.41804288
45TAF15_26573619_Chip-Seq_HEK293_Human1.40082713
46* CBX2_27304074_Chip-Seq_ESCs_Mouse1.39941796
47* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37285733
48AR_25329375_ChIP-Seq_VCAP_Human1.33429929
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.33240226
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33222000
51IRF1_19129219_ChIP-ChIP_H3396_Human1.31244228
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29539918
53IGF1R_20145208_ChIP-Seq_DFB_Human1.27123761
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26855803
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.26534054
56EWS_26573619_Chip-Seq_HEK293_Human1.26197942
57* RING1B_27294783_Chip-Seq_NPCs_Mouse1.24951233
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.23691466
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22757751
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22419298
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21535086
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20749795
63* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20587280
64* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20459855
65AR_19668381_ChIP-Seq_PC3_Human1.19254355
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17934567
67STAT3_23295773_ChIP-Seq_U87_Human1.16209625
68* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15892069
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.13638312
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11792056
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11792056
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11579966
73CBP_20019798_ChIP-Seq_JUKART_Human1.11352684
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11352684
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10840724
76BCAT_22108803_ChIP-Seq_LS180_Human1.10689365
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10490481
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.10348001
79RNF2_27304074_Chip-Seq_NSC_Mouse1.10200862
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08867637
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08263401
82FUS_26573619_Chip-Seq_HEK293_Human1.07902699
83ER_23166858_ChIP-Seq_MCF-7_Human1.07204587
84TCF4_23295773_ChIP-Seq_U87_Human1.07145991
85YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06746944
86* PRDM14_20953172_ChIP-Seq_ESCs_Human1.05913301
87ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05426016
88GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05191561
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03933930
90SMAD_19615063_ChIP-ChIP_OVARY_Human1.03609299
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03121320
92P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02878062
93DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01785915
94MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00334003
95* TP53_20018659_ChIP-ChIP_R1E_Mouse0.98308635
96TP53_16413492_ChIP-PET_HCT116_Human0.98053564
97RUNX2_22187159_ChIP-Seq_PCA_Human0.97840117
98AHR_22903824_ChIP-Seq_MCF-7_Human0.97815164
99* KDM2B_26808549_Chip-Seq_K562_Human0.97523108
100VDR_22108803_ChIP-Seq_LS180_Human0.97315300
101TP53_18474530_ChIP-ChIP_U2OS_Human0.97203915
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96796883
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95989747
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.95284232
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95165018
106PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94779653
107SMAD4_21741376_ChIP-Seq_EPCs_Human0.94439541
108SMAD3_21741376_ChIP-Seq_HESCs_Human0.94420377
109SMAD3_21741376_ChIP-Seq_ESCs_Human0.93651145
110* JUN_21703547_ChIP-Seq_K562_Human0.93372227
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93176070
112TP53_22573176_ChIP-Seq_HFKS_Human0.92742146
113TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92741170
114NCOR_22424771_ChIP-Seq_293T_Human0.92632993
115NANOG_19829295_ChIP-Seq_ESCs_Human0.92457681
116SOX2_19829295_ChIP-Seq_ESCs_Human0.92457681
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92435346
118TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92296327
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91963642
120* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91207780
121* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90862845
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90650446
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90438837
124* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.89612586
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89100355
126* FLI1_21867929_ChIP-Seq_TH2_Mouse0.88585728
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88173342

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.36716600
2MP0003880_abnormal_central_pattern5.17708396
3MP0003635_abnormal_synaptic_transmissio4.39292632
4MP0004270_analgesia3.77375327
5MP0002063_abnormal_learning/memory/cond3.61819193
6* MP0009745_abnormal_behavioral_response3.40990526
7MP0001968_abnormal_touch/_nociception3.06523241
8* MP0002064_seizures3.02671728
9MP0002572_abnormal_emotion/affect_behav2.92367184
10MP0009046_muscle_twitch2.75369288
11MP0005423_abnormal_somatic_nervous2.74149950
12MP0002736_abnormal_nociception_after2.62626754
13MP0002735_abnormal_chemical_nociception2.57471135
14MP0002734_abnormal_mechanical_nocicepti2.55473188
15MP0000778_abnormal_nervous_system2.51479057
16MP0002272_abnormal_nervous_system2.50170047
17MP0001486_abnormal_startle_reflex2.45644099
18MP0008877_abnormal_DNA_methylation2.43761765
19MP0001501_abnormal_sleep_pattern2.23385645
20* MP0001440_abnormal_grooming_behavior2.17494840
21MP0002184_abnormal_innervation2.05557693
22MP0009780_abnormal_chondrocyte_physiolo2.04347597
23MP0002067_abnormal_sensory_capabilities2.03424639
24MP0003329_amyloid_beta_deposits2.01607432
25MP0002733_abnormal_thermal_nociception1.93072321
26MP0008569_lethality_at_weaning1.89284610
27MP0001970_abnormal_pain_threshold1.84447769
28MP0004885_abnormal_endolymph1.83228234
29MP0004858_abnormal_nervous_system1.83021494
30MP0004811_abnormal_neuron_physiology1.82908282
31MP0002557_abnormal_social/conspecific_i1.81322946
32MP0002638_abnormal_pupillary_reflex1.76823901
33MP0003646_muscle_fatigue1.76391419
34MP0002160_abnormal_reproductive_system1.66778000
35MP0003879_abnormal_hair_cell1.66074905
36MP0006072_abnormal_retinal_apoptosis1.66003079
37MP0004924_abnormal_behavior1.64553332
38MP0005386_behavior/neurological_phenoty1.64553332
39MP0000955_abnormal_spinal_cord1.62428306
40MP0003787_abnormal_imprinting1.51644658
41MP0002882_abnormal_neuron_morphology1.49289603
42MP0006276_abnormal_autonomic_nervous1.46833041
43MP0004130_abnormal_muscle_cell1.44798969
44* MP0002066_abnormal_motor_capabilities/c1.41854055
45MP0001984_abnormal_olfaction1.38967232
46MP0005389_reproductive_system_phenotype1.36707000
47MP0002909_abnormal_adrenal_gland1.33754301
48MP0006292_abnormal_olfactory_placode1.33276891
49MP0003633_abnormal_nervous_system1.26187064
50* MP0002152_abnormal_brain_morphology1.25367833
51MP0004145_abnormal_muscle_electrophysio1.24024898
52MP0001502_abnormal_circadian_rhythm1.23547302
53MP0001188_hyperpigmentation1.22569768
54MP0001986_abnormal_taste_sensitivity1.20663360
55MP0005646_abnormal_pituitary_gland1.17441373
56MP0002653_abnormal_ependyma_morphology1.14144111
57MP0003631_nervous_system_phenotype1.13515034
58MP0001905_abnormal_dopamine_level1.13435245
59MP0004142_abnormal_muscle_tone1.10428648
60MP0004510_myositis1.07723113
61MP0004133_heterotaxia1.06774843
62MP0005253_abnormal_eye_physiology1.06574346
63MP0005187_abnormal_penis_morphology1.06417033
64MP0005645_abnormal_hypothalamus_physiol1.05832675
65MP0002822_catalepsy1.05188037
66MP0000049_abnormal_middle_ear1.01776438
67MP0004742_abnormal_vestibular_system1.00152468
68MP0002069_abnormal_eating/drinking_beha0.93842799
69MP0005394_taste/olfaction_phenotype0.93238738
70MP0005499_abnormal_olfactory_system0.93238738
71MP0001919_abnormal_reproductive_system0.92431543
72MP0003195_calcinosis0.92338081
73MP0003283_abnormal_digestive_organ0.90847009
74MP0001963_abnormal_hearing_physiology0.89804345
75MP0001765_abnormal_ion_homeostasis0.89415447
76MP0003632_abnormal_nervous_system0.88940722
77MP0005551_abnormal_eye_electrophysiolog0.87461366
78MP0000631_abnormal_neuroendocrine_gland0.86923456
79MP0000604_amyloidosis0.86756524
80MP0004484_altered_response_of0.83796755
81MP0002229_neurodegeneration0.83214218
82MP0005195_abnormal_posterior_eye0.82139183
83MP0000751_myopathy0.81758238
84MP0002752_abnormal_somatic_nervous0.81452978
85MP0002938_white_spotting0.81388303
86MP0003861_abnormal_nervous_system0.81135895
87MP0002837_dystrophic_cardiac_calcinosis0.81128971
88MP0004019_abnormal_vitamin_homeostasis0.80807334
89MP0008874_decreased_physiological_sensi0.80693350
90MP0000230_abnormal_systemic_arterial0.80656671
91MP0001177_atelectasis0.80154426
92MP0008875_abnormal_xenobiotic_pharmacok0.80097975
93MP0008872_abnormal_physiological_respon0.79900283
94MP0003123_paternal_imprinting0.79271111
95MP0003011_delayed_dark_adaptation0.79177605
96MP0004085_abnormal_heartbeat0.79049367
97MP0000569_abnormal_digit_pigmentation0.78945862
98MP0010386_abnormal_urinary_bladder0.77614478
99MP0009379_abnormal_foot_pigmentation0.77114111
100MP0003075_altered_response_to0.75990277
101MP0004215_abnormal_myocardial_fiber0.74554851
102MP0002876_abnormal_thyroid_physiology0.74516502
103MP0001529_abnormal_vocalization0.74508436
104MP0002234_abnormal_pharynx_morphology0.74397975
105MP0003634_abnormal_glial_cell0.72986275
106MP0003121_genomic_imprinting0.72343760
107MP0003119_abnormal_digestive_system0.70892449
108MP0002138_abnormal_hepatobiliary_system0.70329211
109MP0000026_abnormal_inner_ear0.69525232
110MP0001485_abnormal_pinna_reflex0.68881221
111MP0005535_abnormal_body_temperature0.68334014
112MP0003938_abnormal_ear_development0.67358723
113MP0002163_abnormal_gland_morphology0.65461369
114MP0004134_abnormal_chest_morphology0.65300199
115MP0004233_abnormal_muscle_weight0.64787396
116MP0008961_abnormal_basal_metabolism0.64293513
117MP0005171_absent_coat_pigmentation0.63040791
118MP0005409_darkened_coat_color0.61496308
119MP0001664_abnormal_digestion0.61239401
120MP0003137_abnormal_impulse_conducting0.60101950
121MP0002102_abnormal_ear_morphology0.60073779
122MP0000920_abnormal_myelination0.57114792
123MP0010769_abnormal_survival0.56616390
124MP0002090_abnormal_vision0.56152864
125MP0003122_maternal_imprinting0.56134810
126MP0002082_postnatal_lethality0.53666784
127MP0010770_preweaning_lethality0.53666784
128MP0010768_mortality/aging0.53655835
129* MP0003956_abnormal_body_size0.47435442

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.96366567
2Myokymia (HP:0002411)6.38710955
3Visual hallucinations (HP:0002367)5.95558513
4Focal seizures (HP:0007359)5.78322129
5Epileptic encephalopathy (HP:0200134)5.38885232
6Progressive cerebellar ataxia (HP:0002073)5.09069897
7Febrile seizures (HP:0002373)4.53446047
8Atonic seizures (HP:0010819)4.50597633
9Hyperventilation (HP:0002883)4.23341975
10Broad-based gait (HP:0002136)4.15674630
11Absence seizures (HP:0002121)4.11988126
12Action tremor (HP:0002345)3.93326824
13Dialeptic seizures (HP:0011146)3.89815615
14Generalized tonic-clonic seizures (HP:0002069)3.72103473
15Supranuclear gaze palsy (HP:0000605)3.65528662
16Gaze-evoked nystagmus (HP:0000640)3.58643725
17Amblyopia (HP:0000646)3.54606813
18Poor eye contact (HP:0000817)3.54381327
19Genetic anticipation (HP:0003743)3.44603469
20Excessive salivation (HP:0003781)3.42986808
21Drooling (HP:0002307)3.42986808
22Abolished electroretinogram (ERG) (HP:0000550)3.30958838
23Cerebral inclusion bodies (HP:0100314)3.26953837
24Abnormality of the lower motor neuron (HP:0002366)3.24586769
25Dysmetria (HP:0001310)3.19958438
26Hemiparesis (HP:0001269)3.18672057
27Impaired vibration sensation in the lower limbs (HP:0002166)3.16371700
28Dysdiadochokinesis (HP:0002075)3.11985075
29Abnormality of binocular vision (HP:0011514)3.07601798
30Diplopia (HP:0000651)3.07601798
31True hermaphroditism (HP:0010459)3.07409139
32Congenital stationary night blindness (HP:0007642)3.06284591
33Impaired social interactions (HP:0000735)3.05987916
34Abnormal social behavior (HP:0012433)3.05987916
35Epileptiform EEG discharges (HP:0011182)3.04221869
36Impaired smooth pursuit (HP:0007772)3.01703018
37Mutism (HP:0002300)2.98481204
38Truncal ataxia (HP:0002078)2.96962905
39Pancreatic cysts (HP:0001737)2.94606513
40Clumsiness (HP:0002312)2.93228313
41Nephronophthisis (HP:0000090)2.88929469
42Depression (HP:0000716)2.88593021
43Anxiety (HP:0000739)2.84894980
44Neurofibrillary tangles (HP:0002185)2.84249611
45Absent speech (HP:0001344)2.83978797
46Metabolic alkalosis (HP:0200114)2.82913681
47Pancreatic fibrosis (HP:0100732)2.81148651
48Amyotrophic lateral sclerosis (HP:0007354)2.77023621
49EEG with generalized epileptiform discharges (HP:0011198)2.74505799
50Stereotypic behavior (HP:0000733)2.72907433
51Abnormality of midbrain morphology (HP:0002418)2.72350622
52Molar tooth sign on MRI (HP:0002419)2.72350622
53Urinary bladder sphincter dysfunction (HP:0002839)2.69888181
54Scanning speech (HP:0002168)2.69660662
55Obstructive sleep apnea (HP:0002870)2.65833181
56Limb dystonia (HP:0002451)2.63514256
57Abnormality of the proximal phalanges of the hand (HP:0009834)2.60574068
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.59547923
59Ankle clonus (HP:0011448)2.58038214
60Abnormal eating behavior (HP:0100738)2.57831742
61Hypsarrhythmia (HP:0002521)2.57369063
62Abnormality of ocular smooth pursuit (HP:0000617)2.54985218
63Abnormality of the middle phalanges of the toes (HP:0010183)2.53436453
64Congenital, generalized hypertrichosis (HP:0004540)2.52887884
65Abnormality of the phalanges of the 2nd finger (HP:0009541)2.48150796
66Abnormality of the renal medulla (HP:0100957)2.42874263
67Postural instability (HP:0002172)2.42521828
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.39245740
69Abnormality of the corticospinal tract (HP:0002492)2.36449058
70Short tibia (HP:0005736)2.34681421
71Inappropriate behavior (HP:0000719)2.33638805
72Fetal akinesia sequence (HP:0001989)2.32407054
73Stenosis of the external auditory canal (HP:0000402)2.32301400
74Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.32231408
75Intention tremor (HP:0002080)2.31154741
76Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31035494
77Degeneration of the lateral corticospinal tracts (HP:0002314)2.31035494
78Spastic gait (HP:0002064)2.29157360
79Inability to walk (HP:0002540)2.27815796
80Urinary urgency (HP:0000012)2.27467303
81Abnormality of salivation (HP:0100755)2.27119672
82Megalencephaly (HP:0001355)2.24492471
83Bradykinesia (HP:0002067)2.24206728
84Symphalangism affecting the phalanges of the hand (HP:0009773)2.23663865
85Decreased central vision (HP:0007663)2.23124230
86Abnormality of the phalanges of the 5th finger (HP:0004213)2.20620782
87Asplenia (HP:0001746)2.20545161
88Hemiplegia (HP:0002301)2.19201831
89Fibular aplasia (HP:0002990)2.18643923
90Abnormality of the renal cortex (HP:0011035)2.18547376
91Papilledema (HP:0001085)2.18112355
92Short femoral neck (HP:0100864)2.17474892
93Delusions (HP:0000746)2.16884197
94Termporal pattern (HP:0011008)2.16657202
95Insidious onset (HP:0003587)2.16657202
96Generalized myoclonic seizures (HP:0002123)2.15305847
97Aplasia/Hypoplasia of the spleen (HP:0010451)2.14817879
98Protruding tongue (HP:0010808)2.13367737
99Osteomalacia (HP:0002749)2.13035521
100Medial flaring of the eyebrow (HP:0010747)2.12211829
101Methylmalonic acidemia (HP:0002912)2.12011010
102Hypoplasia of the ulna (HP:0003022)2.11838918
103Progressive inability to walk (HP:0002505)2.11208539
104Status epilepticus (HP:0002133)2.11088934
105Dysmetric saccades (HP:0000641)2.10752064
106Acute necrotizing encephalopathy (HP:0006965)2.10705403
107Hypoplasia of the uterus (HP:0000013)2.10341462
108Impaired vibratory sensation (HP:0002495)2.08402192
109Pendular nystagmus (HP:0012043)2.06222550
110Agitation (HP:0000713)2.05282295
111Incomplete penetrance (HP:0003829)2.04374443
112Abnormal rod and cone electroretinograms (HP:0008323)2.04330315
113Decreased circulating renin level (HP:0003351)2.03477792
114Male pseudohermaphroditism (HP:0000037)2.03465549
115Short hallux (HP:0010109)2.03280204
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99203329
117Aplasia/Hypoplasia of the hallux (HP:0008362)1.98855611
118Abnormality of renin-angiotensin system (HP:0000847)1.98718002
119Focal dystonia (HP:0004373)1.98453070
120Type II lissencephaly (HP:0007260)1.98347557
121Progressive macrocephaly (HP:0004481)1.97287170
122Lower limb asymmetry (HP:0100559)1.97278551
123Aplasia/hypoplasia of the uterus (HP:0008684)1.96263163
1243-Methylglutaconic aciduria (HP:0003535)1.96148094
125Apathy (HP:0000741)1.95859156
126Akinesia (HP:0002304)1.94402555
127Gait ataxia (HP:0002066)1.92164036
128Torticollis (HP:0000473)1.92013132
129Lower limb muscle weakness (HP:0007340)1.90685354
130Small hand (HP:0200055)1.90610377
131Blue irides (HP:0000635)1.90168924
132Cystic liver disease (HP:0006706)1.89168592
133Abnormal drinking behavior (HP:0030082)1.89093892
134Polydipsia (HP:0001959)1.89093892
135Polyphagia (HP:0002591)1.89072151
136Gait imbalance (HP:0002141)1.88644050
137Pointed chin (HP:0000307)1.88029747
138Aplasia/Hypoplasia of the fibula (HP:0006492)1.87942794
139Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.87440087
140Short 4th metacarpal (HP:0010044)1.87365306
141Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87365306
142Anomalous pulmonary venous return (HP:0010772)1.87187590
143Morphological abnormality of the middle ear (HP:0008609)1.86528982
144Abnormality of the renal collecting system (HP:0004742)1.86526907
145Mitochondrial inheritance (HP:0001427)1.86084412
146Insomnia (HP:0100785)1.84741393
147Syncope (HP:0001279)1.84671137
148Specific learning disability (HP:0001328)1.84553458
149Confusion (HP:0001289)1.84153052
150Periauricular skin pits (HP:0100277)1.82953954
151Preauricular pit (HP:0004467)1.82953954
152Oligodontia (HP:0000677)1.82909511
153Abnormal mitochondria in muscle tissue (HP:0008316)1.82690751
154Thickened helices (HP:0000391)1.81586284
155Aqueductal stenosis (HP:0002410)1.81499992
156Bony spicule pigmentary retinopathy (HP:0007737)1.81490796
157Autism (HP:0000717)1.80557297
158Aplasia/Hypoplasia of the brainstem (HP:0007362)1.80312288
159Hypoplasia of the brainstem (HP:0002365)1.80312288
160Goiter (HP:0000853)1.79698477
161Pachygyria (HP:0001302)1.78300706
162Intellectual disability, severe (HP:0010864)1.76145024
163Increased circulating renin level (HP:0000848)1.76035516
164Psychosis (HP:0000709)1.75070762
165Sleep apnea (HP:0010535)1.75066568
166Rapidly progressive (HP:0003678)1.74741603
167Annular pancreas (HP:0001734)1.73413752
168Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.73313946
169Lissencephaly (HP:0001339)1.70089716
170Widely spaced teeth (HP:0000687)1.69999822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.97701816
2NTRK34.62908930
3MARK14.25433787
4FRK3.58417301
5MAP3K93.29976961
6MAP3K42.92000730
7MINK12.73593338
8MAP2K72.64068907
9ADRBK22.48213536
10DAPK22.47795650
11RIPK42.40661617
12GRK12.28842057
13CASK2.16132144
14TLK12.16091127
15PAK62.11377845
16PLK22.10838637
17BMPR1B2.08716089
18TAOK32.05739505
19KSR11.94401293
20SIK21.83698155
21NTRK21.78873588
22DAPK11.78535197
23WNK41.78302161
24MAP2K41.76757110
25PRPF4B1.73148996
26CAMKK11.69387409
27MAPK131.68281001
28MAP3K121.67023383
29TNIK1.63852003
30KSR21.57612671
31CDK51.53510521
32PNCK1.50827044
33PRKD31.50224804
34GRK51.43059509
35MAP4K21.39924794
36PRKCG1.38034655
37CDK191.36154401
38TXK1.35399638
39PTK2B1.27694184
40FES1.23590349
41ZAK1.22883027
42BMPR21.14693516
43NUAK11.13431903
44INSRR1.12659744
45CAMK2A1.12427806
46CAMK2B1.11929554
47STK381.11567351
48NTRK11.10160254
49STK391.05515636
50DYRK1A1.01516498
51ACVR1B1.00225463
52MARK20.98425811
53FGR0.97193139
54LATS20.94820635
55CDK180.93859401
56ADRBK10.93446309
57CAMK10.92621583
58PHKG10.92464191
59PHKG20.92464191
60STK110.92080190
61CDK150.91706761
62RPS6KA20.90670956
63MAP3K130.90080671
64UHMK10.87793553
65GRK70.87128050
66CDK140.86889095
67PRKACA0.83981935
68CAMKK20.83735234
69NME10.82317597
70TYRO30.81785479
71TIE10.81310400
72CDK11A0.80017587
73CSNK1G20.78398446
74RPS6KA60.75661098
75ARAF0.74626900
76MAP3K60.73487726
77RAF10.73167648
78ERBB20.71448370
79EPHB20.71306647
80PIK3CA0.71260270
81TAOK10.71210392
82SGK10.70007130
83SGK2230.68673636
84SGK4940.68673636
85STK160.67288679
86MAP2K20.63022342
87OXSR10.62800773
88MAP3K20.62168914
89CCNB10.61587824
90PAK30.60844774
91PRKCZ0.60153659
92WNK10.59648289
93FGFR20.59234172
94SGK20.59214598
95RET0.58824678
96PRKCA0.57985068
97MAPKAPK50.57258894
98CSNK1A10.54332557
99PDK10.53504850
100PRKCE0.52403892
101OBSCN0.52192057
102RPS6KC10.52078708
103RPS6KL10.52078708
104PRKCQ0.51746868
105CAMK40.51574405
106ERBB30.51288235
107FER0.50248467
108SIK30.49349039
109TAOK20.49306471
110MAP3K70.48660115
111MAPK120.48342181
112CAMK2D0.47248184
113PRKACG0.46528117
114DMPK0.45801260
115FYN0.45610514
116CSNK1G30.45438464
117PDPK10.44482120
118MAPK40.44343992
119MAPK150.43755300
120VRK10.42452380
121PINK10.42191568
122BCKDK0.41071694
123PRKCH0.40633266
124RPS6KA30.40418314
125ALK0.39849263
126TNK20.39698021
127SGK30.39492738
128DYRK20.38877613
129PKN10.37626992
130CSNK1G10.37617864
131CAMK2G0.36981771
132CAMK1G0.36190979
133MAP2K60.34099553
134AKT30.34044883
135GRK60.33892741
136MAPK100.32995979
137PRKG10.31370099
138ROCK20.31233096
139BCR0.30202317
140WNK30.29551022
141MUSK0.28260429
142DAPK30.27700965
143PRKCB0.26601302

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.21220412
2Long-term potentiation_Homo sapiens_hsa047203.07799176
3Circadian entrainment_Homo sapiens_hsa047132.96851869
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.92755810
5Synaptic vesicle cycle_Homo sapiens_hsa047212.91666171
6Glutamatergic synapse_Homo sapiens_hsa047242.86968884
7Amphetamine addiction_Homo sapiens_hsa050312.58300764
8GABAergic synapse_Homo sapiens_hsa047272.53922014
9Morphine addiction_Homo sapiens_hsa050322.51894807
10Olfactory transduction_Homo sapiens_hsa047402.43839475
11Oxidative phosphorylation_Homo sapiens_hsa001902.39095615
12Salivary secretion_Homo sapiens_hsa049702.29008538
13Dopaminergic synapse_Homo sapiens_hsa047282.21029047
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.12658542
15Long-term depression_Homo sapiens_hsa047301.95282334
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.95229384
17Taste transduction_Homo sapiens_hsa047421.93155377
18Insulin secretion_Homo sapiens_hsa049111.89449257
19Gastric acid secretion_Homo sapiens_hsa049711.89306148
20Cholinergic synapse_Homo sapiens_hsa047251.88127117
21Oxytocin signaling pathway_Homo sapiens_hsa049211.78182303
22Parkinsons disease_Homo sapiens_hsa050121.74207843
23Calcium signaling pathway_Homo sapiens_hsa040201.72925567
24Renin secretion_Homo sapiens_hsa049241.70729081
25Serotonergic synapse_Homo sapiens_hsa047261.68550478
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63450886
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.62002168
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51546236
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51376234
30Axon guidance_Homo sapiens_hsa043601.50416728
31GnRH signaling pathway_Homo sapiens_hsa049121.47220723
32Linoleic acid metabolism_Homo sapiens_hsa005911.43498612
33Gap junction_Homo sapiens_hsa045401.35460684
34Cocaine addiction_Homo sapiens_hsa050301.34843190
35cAMP signaling pathway_Homo sapiens_hsa040241.34735935
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32102480
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29488299
38Nitrogen metabolism_Homo sapiens_hsa009101.29396797
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29027156
40Collecting duct acid secretion_Homo sapiens_hsa049661.24474561
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22924425
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.22090266
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21855778
44Type II diabetes mellitus_Homo sapiens_hsa049301.21601359
45Glioma_Homo sapiens_hsa052141.20120278
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19645392
47Estrogen signaling pathway_Homo sapiens_hsa049151.19508564
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.17219023
49Protein export_Homo sapiens_hsa030601.16630162
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12576895
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10519673
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09691111
53Melanogenesis_Homo sapiens_hsa049161.07144719
54ErbB signaling pathway_Homo sapiens_hsa040121.06231716
55Huntingtons disease_Homo sapiens_hsa050161.03357221
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.02702830
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.01247621
58Tryptophan metabolism_Homo sapiens_hsa003800.96766587
59Asthma_Homo sapiens_hsa053100.93622936
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.91757298
61Oocyte meiosis_Homo sapiens_hsa041140.88958982
62Retinol metabolism_Homo sapiens_hsa008300.88740495
63Cardiac muscle contraction_Homo sapiens_hsa042600.88400320
64Choline metabolism in cancer_Homo sapiens_hsa052310.87575181
65Ribosome_Homo sapiens_hsa030100.87384823
66Pancreatic secretion_Homo sapiens_hsa049720.86621883
67Chemical carcinogenesis_Homo sapiens_hsa052040.84378774
68Vitamin digestion and absorption_Homo sapiens_hsa049770.82585380
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.82399781
70VEGF signaling pathway_Homo sapiens_hsa043700.81017510
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80597304
72Ether lipid metabolism_Homo sapiens_hsa005650.79123286
73Phototransduction_Homo sapiens_hsa047440.78739996
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76794998
75Caffeine metabolism_Homo sapiens_hsa002320.76410986
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.75585809
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74295988
78MAPK signaling pathway_Homo sapiens_hsa040100.71534699
79Vibrio cholerae infection_Homo sapiens_hsa051100.70598959
80Thyroid hormone synthesis_Homo sapiens_hsa049180.69199639
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66605554
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66340334
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65936267
84Dilated cardiomyopathy_Homo sapiens_hsa054140.65176618
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.64883515
86Dorso-ventral axis formation_Homo sapiens_hsa043200.64139633
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63112419
88Butanoate metabolism_Homo sapiens_hsa006500.62392563
89Ras signaling pathway_Homo sapiens_hsa040140.60962593
90Regulation of autophagy_Homo sapiens_hsa041400.59272163
91Sulfur metabolism_Homo sapiens_hsa009200.58333144
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.57525615
93Wnt signaling pathway_Homo sapiens_hsa043100.57017135
94Rap1 signaling pathway_Homo sapiens_hsa040150.56713160
95Glucagon signaling pathway_Homo sapiens_hsa049220.56377335
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56101496
97Rheumatoid arthritis_Homo sapiens_hsa053230.54540739
98African trypanosomiasis_Homo sapiens_hsa051430.54186672
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53843589
100Arachidonic acid metabolism_Homo sapiens_hsa005900.52664340
101Circadian rhythm_Homo sapiens_hsa047100.52486129
102Type I diabetes mellitus_Homo sapiens_hsa049400.51930871
103Inositol phosphate metabolism_Homo sapiens_hsa005620.50235415
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49166473
105mTOR signaling pathway_Homo sapiens_hsa041500.48994953
106Endometrial cancer_Homo sapiens_hsa052130.48537674
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47977248
108RNA degradation_Homo sapiens_hsa030180.46930450
109Basal transcription factors_Homo sapiens_hsa030220.45417645
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45216490
111RNA polymerase_Homo sapiens_hsa030200.44846248
112Alzheimers disease_Homo sapiens_hsa050100.43731203
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43573482
114Glycerolipid metabolism_Homo sapiens_hsa005610.42192790
115Colorectal cancer_Homo sapiens_hsa052100.41780544
116Peroxisome_Homo sapiens_hsa041460.41407886
117Renal cell carcinoma_Homo sapiens_hsa052110.39798102
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39714060
119Non-small cell lung cancer_Homo sapiens_hsa052230.39670737
120beta-Alanine metabolism_Homo sapiens_hsa004100.37928803
121Endocytosis_Homo sapiens_hsa041440.37872896
122Histidine metabolism_Homo sapiens_hsa003400.37849800
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37143863
124Primary bile acid biosynthesis_Homo sapiens_hsa001200.36734843
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36404161
126Alcoholism_Homo sapiens_hsa050340.35886790
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35588656
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35549074
129Graft-versus-host disease_Homo sapiens_hsa053320.34603640
130Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34432040
131Bile secretion_Homo sapiens_hsa049760.33739240
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30280061
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29859498
134Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28382794
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28250679
136Chemokine signaling pathway_Homo sapiens_hsa040620.28225187
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28031719
138Insulin signaling pathway_Homo sapiens_hsa049100.26386314
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26321432
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24995030
141Ovarian steroidogenesis_Homo sapiens_hsa049130.24740176
142Prion diseases_Homo sapiens_hsa050200.24661994
143Mineral absorption_Homo sapiens_hsa049780.24374058

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