NEXN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a filamentous actin-binding protein that may function in cell adhesion and migration. Mutations in this gene have been associated with dilated cardiomyopathy, also known as CMD1CC. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.05931579
2sarcomere organization (GO:0045214)9.02734710
3actin-myosin filament sliding (GO:0033275)8.32086159
4muscle filament sliding (GO:0030049)8.32086159
5myofibril assembly (GO:0030239)8.05755210
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.68392328
7actin-mediated cell contraction (GO:0070252)7.24512845
8cardiac muscle contraction (GO:0060048)6.76025429
9negative regulation of potassium ion transmembrane transport (GO:1901380)6.69659951
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.63114787
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.49268103
12regulation of relaxation of muscle (GO:1901077)6.39121296
13* cardiac muscle cell development (GO:0055013)6.34514072
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.18331636
15cardiac muscle tissue morphogenesis (GO:0055008)6.11159430
16regulation of skeletal muscle contraction (GO:0014819)6.05179115
17actomyosin structure organization (GO:0031032)6.03717798
18* cardiac cell development (GO:0055006)5.97555263
19cardiac muscle hypertrophy (GO:0003300)5.91087502
20heart contraction (GO:0060047)5.82810572
21heart process (GO:0003015)5.82810572
22striated muscle hypertrophy (GO:0014897)5.62214727
23striated muscle contraction (GO:0006941)5.61111590
24tricarboxylic acid cycle (GO:0006099)5.58471718
25muscle tissue morphogenesis (GO:0060415)5.56967102
26regulation of actin filament-based movement (GO:1903115)5.46909255
27ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.46253813
28actin filament-based movement (GO:0030048)5.45508851
29sarcoplasmic reticulum calcium ion transport (GO:0070296)5.42358662
30regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.37833095
31regulation of cell communication by electrical coupling (GO:0010649)5.35842305
32regulation of sarcomere organization (GO:0060297)5.35431983
33plasma membrane repair (GO:0001778)5.23907464
34adult heart development (GO:0007512)5.20637402
35response to muscle activity (GO:0014850)5.18726505
36regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.17156021
37ventricular cardiac muscle cell action potential (GO:0086005)5.10083514
38regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.06499841
39muscle hypertrophy (GO:0014896)4.99671321
40heart trabecula formation (GO:0060347)4.87357444
41regulation of cardioblast differentiation (GO:0051890)4.84088689
42regulation of striated muscle contraction (GO:0006942)4.75776280
43bundle of His cell to Purkinje myocyte communication (GO:0086069)4.75215615
44regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.74315345
45negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.70963970
46regulation of acyl-CoA biosynthetic process (GO:0050812)4.67836554
47carnitine shuttle (GO:0006853)4.62634150
48regulation of the force of heart contraction (GO:0002026)4.42859720
49regulation of membrane repolarization (GO:0060306)4.39936929
50ventricular cardiac muscle cell development (GO:0055015)4.37274079
51regulation of coenzyme metabolic process (GO:0051196)4.32258019
52regulation of cofactor metabolic process (GO:0051193)4.32258019
53negative regulation of calcium ion transmembrane transport (GO:1903170)4.25083289
54negative regulation of calcium ion transmembrane transporter activity (GO:1901020)4.25083289
55response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.24771358
56cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.20607700
57negative regulation of striated muscle cell apoptotic process (GO:0010664)4.20168223
58skeletal muscle fiber development (GO:0048741)4.05398297
59cardiac muscle hypertrophy in response to stress (GO:0014898)4.00425336
60muscle hypertrophy in response to stress (GO:0003299)4.00425336
61cardiac muscle adaptation (GO:0014887)4.00425336
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.98531126
63myotube cell development (GO:0014904)3.96592076
64cell communication involved in cardiac conduction (GO:0086065)3.92202070
65creatine metabolic process (GO:0006600)3.91190056
66fatty acid transmembrane transport (GO:1902001)3.90875454
67skeletal muscle tissue development (GO:0007519)3.88965320
68* striated muscle cell development (GO:0055002)3.84843868
69regulation of calcium ion transmembrane transporter activity (GO:1901019)3.84169164
70regulation of calcium ion transmembrane transport (GO:1903169)3.84169164
71muscle cell fate commitment (GO:0042693)3.83460470
72mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.82435065
73muscle contraction (GO:0006936)3.81854992
74ATP synthesis coupled proton transport (GO:0015986)3.79977628
75energy coupled proton transport, down electrochemical gradient (GO:0015985)3.79977628
76muscle cell cellular homeostasis (GO:0046716)3.79631107
77skeletal muscle contraction (GO:0003009)3.78373603
78negative regulation of protein localization to cell surface (GO:2000009)3.78156474
79oxidative phosphorylation (GO:0006119)3.75978376
80cardiac muscle cell action potential (GO:0086001)3.73722748
81regulation of cardiac muscle contraction (GO:0055117)3.73501813
82regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.72499066
83cardiac muscle cell action potential involved in contraction (GO:0086002)3.70600012
84respiratory electron transport chain (GO:0022904)3.69314569
85regulation of heart rate (GO:0002027)3.67866448
86relaxation of cardiac muscle (GO:0055119)3.66815853
87regulation of ATP catabolic process (GO:1903289)3.62577478
88regulation of ATPase activity (GO:0043462)3.62577478
89positive regulation of myoblast differentiation (GO:0045663)3.61754791
90cell communication by electrical coupling (GO:0010644)3.58226729
91electron transport chain (GO:0022900)3.57990430
92skeletal muscle tissue regeneration (GO:0043403)3.57675395
93* muscle fiber development (GO:0048747)3.57204131
94muscle system process (GO:0003012)3.57185735
95skeletal muscle adaptation (GO:0043501)3.56357977
96regulation of sulfur metabolic process (GO:0042762)3.55828025
97relaxation of muscle (GO:0090075)3.51084941
98striated muscle adaptation (GO:0014888)3.46450726
99negative regulation of potassium ion transport (GO:0043267)3.45602583
100membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43714630
101regulation of striated muscle cell apoptotic process (GO:0010662)3.41961836
102regulation of muscle contraction (GO:0006937)3.39126759
103regulation of cardiac muscle cell contraction (GO:0086004)3.37654239
104regulation of heart contraction (GO:0008016)3.36528117
105striated muscle atrophy (GO:0014891)3.36517953
106muscle organ development (GO:0007517)3.34902317
107muscle structure development (GO:0061061)3.34226124
108response to inactivity (GO:0014854)3.33782386
109positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.30592384
110carnitine transmembrane transport (GO:1902603)3.29340434
111* muscle cell development (GO:0055001)3.28776108
112cardiac conduction (GO:0061337)3.28169513
113regulation of myoblast differentiation (GO:0045661)3.21689541
114cardiac chamber formation (GO:0003207)3.21298102
115negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.20939890
116trabecula formation (GO:0060343)3.18121873
117positive regulation of heart contraction (GO:0045823)3.15237009
118atrial septum morphogenesis (GO:0060413)3.14154251
119regulation of heart rate by cardiac conduction (GO:0086091)3.13543995
120response to caffeine (GO:0031000)3.12080464
121positive regulation of heart rate (GO:0010460)3.10271077
122regulation of muscle system process (GO:0090257)3.08573329
123striated muscle tissue development (GO:0014706)3.07509350
124myoblast fusion (GO:0007520)3.07395520
125positive regulation of cation channel activity (GO:2001259)3.06287220
126response to epinephrine (GO:0071871)2.97950438
127positive regulation of myotube differentiation (GO:0010831)2.96513084
128NADH metabolic process (GO:0006734)2.94571912
129regulation of sequestering of triglyceride (GO:0010889)2.92542418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse6.11888735
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.76715835
3MEF2A_21415370_ChIP-Seq_HL-1_Mouse4.13614811
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.11532845
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.06216701
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.98611610
7TBX20_22328084_ChIP-Seq_HEART_Mouse3.87438991
8TBX20_22080862_ChIP-Seq_HEART_Mouse3.87438991
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.36792659
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.10515197
11* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.90726364
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.77493696
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.76461594
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.21597338
15GBX2_23144817_ChIP-Seq_PC3_Human2.04755095
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01219776
17* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.95203878
18ISL1_27105846_Chip-Seq_CPCs_Mouse1.92927721
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.87453070
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85311595
21EZH2_22144423_ChIP-Seq_EOC_Human1.61268128
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60043596
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.56666823
24* CJUN_26792858_Chip-Seq_BT549_Human1.52435723
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.43510441
26ZNF263_19887448_ChIP-Seq_K562_Human1.43152483
27AUTS2_25519132_ChIP-Seq_293T-REX_Human1.42319201
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.41347058
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40839065
30ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39494558
31LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39281470
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36689353
33* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35960229
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33956177
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.33916453
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33310427
37FLI1_27457419_Chip-Seq_LIVER_Mouse1.33071905
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29785828
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28535033
40BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26910692
41BCAT_22108803_ChIP-Seq_LS180_Human1.26305118
42PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26131318
43* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25435131
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24939365
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.24400153
46ZNF274_21170338_ChIP-Seq_K562_Hela1.23528985
47SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22901999
48* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19283031
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18005723
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17029651
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15850190
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14290820
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14098693
54TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13828770
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.13632936
56TP53_18474530_ChIP-ChIP_U2OS_Human1.13503222
57* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.13230009
58GATA1_22025678_ChIP-Seq_K562_Human1.13225984
59ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12905208
60TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10942255
61* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.10111247
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10088765
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09724048
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08489061
65* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08149320
66* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08149320
67SMC3_22415368_ChIP-Seq_MEFs_Mouse1.07571879
68* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05708203
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.04162595
70SMAD4_21799915_ChIP-Seq_A2780_Human1.03336945
71SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02395948
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01758753
73SMAD3_21741376_ChIP-Seq_HESCs_Human1.00894779
74SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00294411
75* TBL1_22424771_ChIP-Seq_293T_Human1.00167468
76TP53_16413492_ChIP-PET_HCT116_Human0.99992477
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99953494
78* EZH2_27294783_Chip-Seq_ESCs_Mouse0.99581367
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98859613
80TCF4_18268006_ChIP-ChIP_LS174T_Human0.98540315
81WT1_19549856_ChIP-ChIP_CCG9911_Human0.98331480
82NFE2_27457419_Chip-Seq_LIVER_Mouse0.97802972
83OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97416555
84HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96033462
85CLOCK_20551151_ChIP-Seq_293T_Human0.95265579
86CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93817109
87EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93460347
88* SOX2_21211035_ChIP-Seq_LN229_Gbm0.92427692
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91831009
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89766752
91P53_22387025_ChIP-Seq_ESCs_Mouse0.89646883
92UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89572622
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89505924
94TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88692933
95ESR2_21235772_ChIP-Seq_MCF-7_Human0.87905888
96TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87666380
97SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87663424
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87494281
99NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87300023
100DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.86870197
101NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86865371
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86865371
103E2F1_18555785_Chip-Seq_ESCs_Mouse0.86662165
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86361204
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86269516
106EZH2_27304074_Chip-Seq_ESCs_Mouse0.86255696
107* NFYA_21822215_ChIP-Seq_K562_Human0.85642097
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85118656
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84892300
110FUS_26573619_Chip-Seq_HEK293_Human0.84197054
111GATA2_21666600_ChIP-Seq_HMVEC_Human0.83945893
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.83930033
113BRD4_25478319_ChIP-Seq_HGPS_Human0.83546110
114CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83062183
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82640366
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82241339
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.82237544
118PIAS1_25552417_ChIP-Seq_VCAP_Human0.82163750
119VDR_22108803_ChIP-Seq_LS180_Human0.81664514
120NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81568048
121CDX2_22108803_ChIP-Seq_LS180_Human0.80797703
122ATF3_27146783_Chip-Seq_COLON_Human0.80549145
123PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80296122
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79948498
125WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79310655
126GF1_26923725_Chip-Seq_HPCs_Mouse0.78560542
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.78517863
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.78218186
129PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78155565
130NFI_21473784_ChIP-Seq_ESCs_Mouse0.77512110
131* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.76532919
132FOXM1_23109430_ChIP-Seq_U2OS_Human0.75256607
133CBP_21632823_ChIP-Seq_H3396_Human0.75060437
134TP63_23658742_ChIP-Seq_EP156T_Human0.74723474
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74580222
136AR_19668381_ChIP-Seq_PC3_Human0.74575187
137ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73666166
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71985367
139SRF_21415370_ChIP-Seq_HL-1_Mouse0.71728679
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.71578244
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71308543
142CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70846220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.65765574
2MP0003646_muscle_fatigue5.36586742
3MP0002837_dystrophic_cardiac_calcinosis5.36392734
4MP0000751_myopathy4.71312602
5MP0000749_muscle_degeneration4.49549315
6MP0004036_abnormal_muscle_relaxation4.33360661
7MP0004215_abnormal_myocardial_fiber4.32663368
8MP0005330_cardiomyopathy3.75196053
9MP0004145_abnormal_muscle_electrophysio3.40803558
10MP0004087_abnormal_muscle_fiber3.21132462
11MP0002972_abnormal_cardiac_muscle3.19953304
12MP0005620_abnormal_muscle_contractility2.96513560
13MP0008775_abnormal_heart_ventricle2.94660998
14MP0002106_abnormal_muscle_physiology2.80589349
15MP0000750_abnormal_muscle_regeneration2.76668542
16MP0003137_abnormal_impulse_conducting2.73689714
17MP0004484_altered_response_of2.65580379
18MP0010630_abnormal_cardiac_muscle2.63741722
19MP0001544_abnormal_cardiovascular_syste2.55642445
20MP0005385_cardiovascular_system_phenoty2.55642445
21MP0006138_congestive_heart_failure2.43143968
22MP0002269_muscular_atrophy2.35966327
23MP0003221_abnormal_cardiomyocyte_apopto2.30552011
24MP0005369_muscle_phenotype2.27017958
25MP0003828_pulmonary_edema2.22090282
26MP0004510_myositis2.17640785
27MP0004085_abnormal_heartbeat2.11285625
28MP0000759_abnormal_skeletal_muscle2.09661903
29MP0000747_muscle_weakness2.04538498
30MP0004130_abnormal_muscle_cell2.02674052
31MP0002127_abnormal_cardiovascular_syste2.00152250
32MP0003950_abnormal_plasma_membrane1.97861012
33MP0004233_abnormal_muscle_weight1.90990487
34MP0005451_abnormal_body_composition1.81660138
35MP0003567_abnormal_fetal_cardiomyocyte1.69148299
36MP0006036_abnormal_mitochondrial_physio1.60305189
37MP0001958_emphysema1.49179615
38MP0002332_abnormal_exercise_endurance1.38746358
39MP0010368_abnormal_lymphatic_system1.28060662
40MP0000266_abnormal_heart_morphology1.27276180
41MP0009780_abnormal_chondrocyte_physiolo1.25794425
42MP0010030_abnormal_orbit_morphology1.11653234
43MP0005666_abnormal_adipose_tissue0.97565563
44MP0000733_abnormal_muscle_development0.94896453
45MP0003279_aneurysm0.94359816
46MP0002234_abnormal_pharynx_morphology0.94246535
47MP0009384_cardiac_valve_regurgitation0.92801557
48MP0001661_extended_life_span0.91823647
49MP0000343_altered_response_to0.91420052
50MP0001542_abnormal_bone_strength0.88487595
51MP0002108_abnormal_muscle_morphology0.87587016
52MP0006035_abnormal_mitochondrial_morpho0.86991422
53MP0004185_abnormal_adipocyte_glucose0.86220303
54MP0005165_increased_susceptibility_to0.83327711
55MP0002128_abnormal_blood_circulation0.81226770
56MP0008004_abnormal_stomach_pH0.79754141
57MP0000767_abnormal_smooth_muscle0.79630507
58MP0003566_abnormal_cell_adhesion0.79098069
59MP0003045_fibrosis0.76244045
60MP0004134_abnormal_chest_morphology0.74371593
61MP0005670_abnormal_white_adipose0.73599956
62MP0003984_embryonic_growth_retardation0.73166730
63MP0000230_abnormal_systemic_arterial0.73156823
64MP0001348_abnormal_lacrimal_gland0.72436820
65MP0002088_abnormal_embryonic_growth/wei0.72252032
66MP0005266_abnormal_metabolism0.66775035
67MP0004272_abnormal_basement_membrane0.66468930
68MP0002295_abnormal_pulmonary_circulatio0.65742720
69MP0002925_abnormal_cardiovascular_devel0.65394764
70MP0003385_abnormal_body_wall0.63942566
71MP0002896_abnormal_bone_mineralization0.61345468
72MP0003705_abnormal_hypodermis_morpholog0.57997051
73MP0005623_abnormal_meninges_morphology0.57596826
74MP0003121_genomic_imprinting0.57219362
75MP0005375_adipose_tissue_phenotype0.56888725
76MP0005380_embryogenesis_phenotype0.56159106
77MP0001672_abnormal_embryogenesis/_devel0.56159106
78MP0003123_paternal_imprinting0.55697562
79MP0009250_abnormal_appendicular_skeleto0.51426728
80MP0001879_abnormal_lymphatic_vessel0.50880420
81MP0003122_maternal_imprinting0.50852946
82MP0001784_abnormal_fluid_regulation0.50728661
83MP0003091_abnormal_cell_migration0.50681891
84MP0005187_abnormal_penis_morphology0.49923250
85MP0001614_abnormal_blood_vessel0.49591519
86MP0002971_abnormal_brown_adipose0.48838335
87MP0003941_abnormal_skin_development0.48596528
88MP0005023_abnormal_wound_healing0.47711947
89MP0005503_abnormal_tendon_morphology0.44983463
90MP0004270_analgesia0.44613422
91MP0008438_abnormal_cutaneous_collagen0.44533885
92MP0000534_abnormal_ureter_morphology0.41974232
93MP0001697_abnormal_embryo_size0.38991269
94MP0002877_abnormal_melanocyte_morpholog0.37913180
95MP0005508_abnormal_skeleton_morphology0.37773577
96MP0000249_abnormal_blood_vessel0.36779665
97MP0001299_abnormal_eye_distance/0.36501351
98MP0005464_abnormal_platelet_physiology0.36468716
99MP0001730_embryonic_growth_arrest0.35598492
100MP0003935_abnormal_craniofacial_develop0.35573121
101MP0004043_abnormal_pH_regulation0.35445329
102MP0005275_abnormal_skin_tensile0.34794346
103MP0003937_abnormal_limbs/digits/tail_de0.33519069
104MP0005171_absent_coat_pigmentation0.32871366
105MP0002114_abnormal_axial_skeleton0.32046997
106MP0001529_abnormal_vocalization0.31600972
107MP0002168_other_aberrant_phenotype0.31585783
108MP0003948_abnormal_gas_homeostasis0.30657062
109MP0003879_abnormal_hair_cell0.30501492
110MP0002249_abnormal_larynx_morphology0.29895893
111MP0000003_abnormal_adipose_tissue0.29721134
112MP0001727_abnormal_embryo_implantation0.28129399
113MP0004142_abnormal_muscle_tone0.28055938
114MP0003718_maternal_effect0.27556076
115MP0002102_abnormal_ear_morphology0.27518750
116MP0009672_abnormal_birth_weight0.26879771
117MP0005083_abnormal_biliary_tract0.26714046
118MP0008877_abnormal_DNA_methylation0.26471131
119MP0000428_abnormal_craniofacial_morphol0.26279312
120MP0000013_abnormal_adipose_tissue0.26158736
121MP0001175_abnormal_lung_morphology0.25798197
122MP0002086_abnormal_extraembryonic_tissu0.25346472
123MP0005595_abnormal_vascular_smooth0.25090697
124MP0000762_abnormal_tongue_morphology0.25089915
125MP0002133_abnormal_respiratory_system0.24610153
126MP0005388_respiratory_system_phenotype0.24610153
127MP0003115_abnormal_respiratory_system0.23448284

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.78717396
2Ventricular tachycardia (HP:0004756)6.59134865
3Calf muscle hypertrophy (HP:0008981)6.55998429
4Exercise-induced muscle cramps (HP:0003710)6.54439649
5Muscle hypertrophy of the lower extremities (HP:0008968)6.15682738
6Exercise-induced myalgia (HP:0003738)6.11014630
7* Atrial fibrillation (HP:0005110)5.61968611
8Subaortic stenosis (HP:0001682)5.56839287
9Abnormality of the left ventricular outflow tract (HP:0011103)5.56839287
10Abnormality of the calf musculature (HP:0001430)5.46668870
11Muscle fiber splitting (HP:0003555)5.39282579
12* Primary atrial arrhythmia (HP:0001692)5.22268234
13* Lipoatrophy (HP:0100578)5.06735092
14* Supraventricular tachycardia (HP:0004755)5.02089645
15* Supraventricular arrhythmia (HP:0005115)4.90711508
16Hyporeflexia of lower limbs (HP:0002600)4.77098344
17Right ventricular cardiomyopathy (HP:0011663)4.75884642
18Myoglobinuria (HP:0002913)4.60804755
19Syncope (HP:0001279)4.55607170
20EMG: myopathic abnormalities (HP:0003458)4.40834877
21Bundle branch block (HP:0011710)4.20549724
22Ventricular arrhythmia (HP:0004308)4.11747336
23* Dilated cardiomyopathy (HP:0001644)4.05733820
24Ulnar deviation of the wrist (HP:0003049)4.01182559
25Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.97609952
26Muscle fiber inclusion bodies (HP:0100299)3.96824109
27Prolonged QT interval (HP:0001657)3.94022583
28Asymmetric septal hypertrophy (HP:0001670)3.89364226
29Type 1 muscle fiber predominance (HP:0003803)3.82739128
30Rhabdomyolysis (HP:0003201)3.79725855
31Palpitations (HP:0001962)3.75499012
32Heart block (HP:0012722)3.60066683
33Calcaneovalgus deformity (HP:0001848)3.58662134
34Increased connective tissue (HP:0009025)3.55988244
35Nemaline bodies (HP:0003798)3.44139637
36Abnormal atrioventricular conduction (HP:0005150)3.42276963
37Atrioventricular block (HP:0001678)3.38578006
38Difficulty running (HP:0009046)3.31183274
39Deformed tarsal bones (HP:0008119)3.25653246
40Ventricular fibrillation (HP:0001663)3.19721966
41Myotonia (HP:0002486)3.13398710
42Absent phalangeal crease (HP:0006109)3.10665661
43Aortic aneurysm (HP:0004942)2.94852967
44Neck muscle weakness (HP:0000467)2.90813507
45Abnormal EKG (HP:0003115)2.83365810
46Fatigable weakness (HP:0003473)2.79372050
47Abnormality of the neuromuscular junction (HP:0003398)2.79372050
48Acute necrotizing encephalopathy (HP:0006965)2.77661143
49Malignant hyperthermia (HP:0002047)2.76966378
50Abnormal mitochondria in muscle tissue (HP:0008316)2.74326232
51* Left ventricular hypertrophy (HP:0001712)2.74002830
52Weak cry (HP:0001612)2.72051484
53Areflexia of lower limbs (HP:0002522)2.68776252
54Popliteal pterygium (HP:0009756)2.64512902
55Distal lower limb muscle weakness (HP:0009053)2.57906850
56Difficulty climbing stairs (HP:0003551)2.56919539
57Rimmed vacuoles (HP:0003805)2.56047500
58Hepatic necrosis (HP:0002605)2.55447963
59Frequent falls (HP:0002359)2.52573865
60Muscle stiffness (HP:0003552)2.51814468
61Abnormal finger flexion creases (HP:0006143)2.51134087
62Spinal rigidity (HP:0003306)2.48091170
63Type 2 muscle fiber atrophy (HP:0003554)2.46050366
64Fetal akinesia sequence (HP:0001989)2.41179089
65* Palmoplantar keratoderma (HP:0000982)2.40936287
66Slender build (HP:0001533)2.40603422
67Distal lower limb amyotrophy (HP:0008944)2.39296776
68Aplasia of the musculature (HP:0100854)2.37699744
69Increased variability in muscle fiber diameter (HP:0003557)2.35278784
70Bulbar palsy (HP:0001283)2.30939543
71Progressive macrocephaly (HP:0004481)2.30408100
72Congenital malformation of the right heart (HP:0011723)2.29581911
73Double outlet right ventricle (HP:0001719)2.29581911
74Acute encephalopathy (HP:0006846)2.28549289
75Ragged-red muscle fibers (HP:0003200)2.28517287
76Abnormality of skeletal muscle fiber size (HP:0012084)2.28300415
77Generalized muscle weakness (HP:0003324)2.24675334
78Muscle fiber atrophy (HP:0100295)2.24440001
79Exercise intolerance (HP:0003546)2.24229310
80Hypoplastic ischia (HP:0003175)2.23167129
81Hepatocellular necrosis (HP:0001404)2.19187549
82Increased CSF lactate (HP:0002490)2.19133439
83EMG: neuropathic changes (HP:0003445)2.18532124
84Mitochondrial inheritance (HP:0001427)2.18186763
85Distal arthrogryposis (HP:0005684)2.15046752
86Protrusio acetabuli (HP:0003179)2.13621011
87Centrally nucleated skeletal muscle fibers (HP:0003687)2.12947850
88Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10635977
89Abnormality of alanine metabolism (HP:0010916)2.10635977
90Hyperalaninemia (HP:0003348)2.10635977
91Abnormality of the shoulder girdle musculature (HP:0001435)2.09041494
92Gowers sign (HP:0003391)2.09015323
93Aortic dissection (HP:0002647)2.08708020
94Increased serum pyruvate (HP:0003542)2.08469592
95Abnormality of glycolysis (HP:0004366)2.08469592
96Abnormality of the calcaneus (HP:0008364)2.05434233
97Conjunctival hamartoma (HP:0100780)2.05324270
98Hypoplastic left heart (HP:0004383)2.04651885
99Abnormality of the foot musculature (HP:0001436)2.03174364
100Abnormality of placental membranes (HP:0011409)2.01407154
101Amniotic constriction ring (HP:0009775)2.01407154
102Premature rupture of membranes (HP:0001788)2.00817024
103Muscular dystrophy (HP:0003560)2.00200649
104Mildly elevated creatine phosphokinase (HP:0008180)1.99739109
105Scapular winging (HP:0003691)1.98669201
106Waddling gait (HP:0002515)1.98052539
107Round ear (HP:0100830)1.97712871
108Respiratory insufficiency due to muscle weakness (HP:0002747)1.97690149
109Limited hip movement (HP:0008800)1.96388277
110Hip contracture (HP:0003273)1.96159186
111Lower limb amyotrophy (HP:0007210)1.90872958
112Abnormality of the ischium (HP:0003174)1.90564751
113Cerebral edema (HP:0002181)1.90164678
114Hyperglycemia (HP:0003074)1.90054077
115Hypoplastic heart (HP:0001961)1.89288115
116Increased muscle lipid content (HP:0009058)1.87549810
117Hypoglycemic coma (HP:0001325)1.86379666
118Infantile muscular hypotonia (HP:0008947)1.86055439
119Congestive heart failure (HP:0001635)1.85968398
120Sudden cardiac death (HP:0001645)1.85851421
121Foot dorsiflexor weakness (HP:0009027)1.84936091
122Proximal amyotrophy (HP:0007126)1.79966771
123Lactic acidosis (HP:0003128)1.78809004
124Ketoacidosis (HP:0001993)1.78120213
125Limb-girdle muscle atrophy (HP:0003797)1.77708435
126Limb-girdle muscle weakness (HP:0003325)1.77703991
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.76815633
128Neoplasm of the adrenal gland (HP:0100631)1.76714531
129Facial diplegia (HP:0001349)1.75890212
130Respiratory failure (HP:0002878)1.73320258
131Increased intramyocellular lipid droplets (HP:0012240)1.72470892
132Pheochromocytoma (HP:0002666)1.70476819
133Dicarboxylic aciduria (HP:0003215)1.69691334
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.69691334
135Myopathic facies (HP:0002058)1.69635998
136Abnormality of the tricuspid valve (HP:0001702)1.68739709
137Progressive muscle weakness (HP:0003323)1.65160340

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.79338040
2TTN4.47226829
3MYLK3.76362661
4DMPK3.52146772
5STK243.26331201
6STK38L3.14656276
7PHKG23.13963838
8PHKG13.13963838
9MUSK2.82861845
10PDK42.76731648
11PDK32.76731648
12PIK3CA2.59977906
13PKN22.42386067
14LATS12.32858580
15ZAK2.32787614
16LMTK22.22532768
17NEK12.21043162
18LATS21.95070754
19PINK11.75068338
20TRIB31.65270108
21PDK21.57853147
22ILK1.47685875
23TIE11.29787736
24TRPM71.23081239
25CDC42BPA1.11557029
26MAP3K61.06767909
27ROCK11.06288341
28MARK11.04543466
29MAP3K51.04154922
30BCKDK1.01955843
31PAK31.00432001
32GRK70.97277149
33STK30.96421242
34PRKAA20.96350040
35PRKAA10.92431434
36CAMK2D0.92180476
37DDR20.91875815
38PRKD10.91291541
39STK380.88946311
40TGFBR20.87180440
41LIMK10.86905632
42PRKD30.85814589
43MAP3K70.85269812
44PLK40.84540116
45WNK40.82928410
46MAPK70.80282825
47STK40.78143448
48PTK2B0.75917131
49MAP2K10.71606221
50MAPK120.70846834
51NEK90.69191197
52TAOK10.68931006
53MAPKAPK30.68318187
54CCNB10.60941273
55ERBB40.59084832
56NUAK10.58358905
57PIK3CG0.56336577
58WNK10.55444718
59ADRBK10.55274122
60CAMK2A0.54841679
61NME10.53863276
62CAMK2B0.50488771
63MAP2K30.50448019
64PKN10.49977013
65TTK0.49833301
66FLT30.49059207
67INSRR0.48475189
68MAP2K40.47887996
69MAPK40.46520567
70DAPK30.46495354
71PDGFRA0.45747320
72CDK80.44831003
73CAMK10.43466010
74MAP3K40.43288640
75PRKACB0.43097132
76ROCK20.43073481
77CAMK40.42142898
78PTK20.41451038
79PNCK0.41042933
80AKT20.40510201
81RAF10.40335347
82MOS0.39897058
83ERBB30.39428808
84STK390.38048856
85GRK50.36670159
86KSR20.36542393
87CAMK2G0.34448249
88MAP3K30.33970581
89PRKACG0.33538065
90MELK0.32921081
91BMX0.32643531
92RPS6KA60.31072013
93PRKACA0.30642573
94EPHB20.29450506
95AKT30.28323323
96RPS6KA20.27996349
97PRKG10.27279329
98MAP3K90.27173779
99RIPK10.24900716
100ADRBK20.24647760
101DYRK1B0.24299527
102MAP3K120.23875578
103MARK30.23348213
104PAK10.22571429
105PAK20.22306741
106PAK60.21868853
107FRK0.21098743
108RET0.20799767
109BRSK20.20540111
110BMPR1B0.20182634
111AURKB0.19729465
112BRAF0.19644273
113PRKCE0.18952425
114PLK20.18781222
115TESK10.18464515
116NLK0.18244620
117PRKD20.18023953
118ABL20.17949836
119PDGFRB0.17854241
120TNIK0.17259184
121SGK20.17180160
122SGK10.17157211
123GSK3A0.16566808
124RPS6KC10.16175388
125RPS6KL10.16175388
126EPHA30.15804267
127GRK10.15409616
128TAOK20.15145220
129SGK30.14484262
130RPS6KA30.12505245
131MAPK130.11825066
132MTOR0.11678662

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.52613315
2Cardiac muscle contraction_Homo sapiens_hsa042604.90726120
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.42908970
4Dilated cardiomyopathy_Homo sapiens_hsa054144.30097535
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.46742656
6Parkinsons disease_Homo sapiens_hsa050123.31746124
7Oxidative phosphorylation_Homo sapiens_hsa001903.09206459
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.01235964
9Propanoate metabolism_Homo sapiens_hsa006402.77827776
10Alzheimers disease_Homo sapiens_hsa050102.35541286
11Huntingtons disease_Homo sapiens_hsa050162.33143123
12Carbon metabolism_Homo sapiens_hsa012002.26403771
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.13090521
14Fatty acid degradation_Homo sapiens_hsa000712.08132045
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01275220
16Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.99836255
17Viral myocarditis_Homo sapiens_hsa054161.63126139
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60138117
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.53466573
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51861360
21Pyruvate metabolism_Homo sapiens_hsa006201.47916994
22Fatty acid metabolism_Homo sapiens_hsa012121.43507481
23cGMP-PKG signaling pathway_Homo sapiens_hsa040221.36602129
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23259474
25Glucagon signaling pathway_Homo sapiens_hsa049221.22270950
26Circadian rhythm_Homo sapiens_hsa047101.15194418
27Biosynthesis of amino acids_Homo sapiens_hsa012301.10414648
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07970647
29Insulin resistance_Homo sapiens_hsa049311.02702851
30Starch and sucrose metabolism_Homo sapiens_hsa005001.02576822
31Focal adhesion_Homo sapiens_hsa045101.02400589
32HIF-1 signaling pathway_Homo sapiens_hsa040661.02146226
33Oxytocin signaling pathway_Homo sapiens_hsa049211.01719910
34Insulin signaling pathway_Homo sapiens_hsa049101.00939223
35Tight junction_Homo sapiens_hsa045300.98363202
36Vascular smooth muscle contraction_Homo sapiens_hsa042700.95426305
37Adherens junction_Homo sapiens_hsa045200.94422691
38Nitrogen metabolism_Homo sapiens_hsa009100.93519561
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90189517
40Calcium signaling pathway_Homo sapiens_hsa040200.89048137
41Pancreatic secretion_Homo sapiens_hsa049720.85558002
42Butanoate metabolism_Homo sapiens_hsa006500.81231756
43Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79825459
44Gap junction_Homo sapiens_hsa045400.78727765
45Galactose metabolism_Homo sapiens_hsa000520.78189141
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.75659881
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74173400
48AMPK signaling pathway_Homo sapiens_hsa041520.72599082
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.71960418
50Arginine biosynthesis_Homo sapiens_hsa002200.70951926
51Lysine degradation_Homo sapiens_hsa003100.67547685
52RNA degradation_Homo sapiens_hsa030180.65918660
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.65570694
54Ovarian steroidogenesis_Homo sapiens_hsa049130.63663457
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62430275
56Fatty acid elongation_Homo sapiens_hsa000620.59827401
57Pentose phosphate pathway_Homo sapiens_hsa000300.59166015
58Protein digestion and absorption_Homo sapiens_hsa049740.58580673
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58057168
60Sulfur metabolism_Homo sapiens_hsa009200.56797350
61Salivary secretion_Homo sapiens_hsa049700.56076445
62cAMP signaling pathway_Homo sapiens_hsa040240.55918313
63TGF-beta signaling pathway_Homo sapiens_hsa043500.54983163
64ECM-receptor interaction_Homo sapiens_hsa045120.53544928
65Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51972431
66PPAR signaling pathway_Homo sapiens_hsa033200.50975516
67Type II diabetes mellitus_Homo sapiens_hsa049300.48474646
68FoxO signaling pathway_Homo sapiens_hsa040680.45965963
69Fructose and mannose metabolism_Homo sapiens_hsa000510.44832474
70Arginine and proline metabolism_Homo sapiens_hsa003300.41491464
71GnRH signaling pathway_Homo sapiens_hsa049120.40633260
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40502210
73Renal cell carcinoma_Homo sapiens_hsa052110.40133592
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39028126
75Proteoglycans in cancer_Homo sapiens_hsa052050.38981164
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38427154
77mTOR signaling pathway_Homo sapiens_hsa041500.37486870
78Hippo signaling pathway_Homo sapiens_hsa043900.37465851
79Phenylalanine metabolism_Homo sapiens_hsa003600.36662016
80Oocyte meiosis_Homo sapiens_hsa041140.35478806
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35304425
82beta-Alanine metabolism_Homo sapiens_hsa004100.34672357
83Long-term potentiation_Homo sapiens_hsa047200.34032567
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32573664
85Renin secretion_Homo sapiens_hsa049240.32511955
86Amphetamine addiction_Homo sapiens_hsa050310.32054068
87Dorso-ventral axis formation_Homo sapiens_hsa043200.31305219
88Linoleic acid metabolism_Homo sapiens_hsa005910.31132987
89Cell cycle_Homo sapiens_hsa041100.30345968
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.29892435
91Amoebiasis_Homo sapiens_hsa051460.29581317
92Hedgehog signaling pathway_Homo sapiens_hsa043400.28934556
93Serotonergic synapse_Homo sapiens_hsa047260.28676773
94Basal transcription factors_Homo sapiens_hsa030220.27413621
95Regulation of autophagy_Homo sapiens_hsa041400.26864691
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26613465
97Platelet activation_Homo sapiens_hsa046110.26160606
98GABAergic synapse_Homo sapiens_hsa047270.25966291
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25372094
100Insulin secretion_Homo sapiens_hsa049110.24846336
101Small cell lung cancer_Homo sapiens_hsa052220.24163151
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23484930
103MicroRNAs in cancer_Homo sapiens_hsa052060.22795164
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21939689
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.21511024
106Long-term depression_Homo sapiens_hsa047300.21295887
107Circadian entrainment_Homo sapiens_hsa047130.21219406
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.20482727
109Arachidonic acid metabolism_Homo sapiens_hsa005900.20078833
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18958485
111Gastric acid secretion_Homo sapiens_hsa049710.18418271
112MAPK signaling pathway_Homo sapiens_hsa040100.18114287
113Endometrial cancer_Homo sapiens_hsa052130.17652909
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17438078
115Metabolic pathways_Homo sapiens_hsa011000.17268437
116Tryptophan metabolism_Homo sapiens_hsa003800.14039083
117Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.13698492
118Olfactory transduction_Homo sapiens_hsa047400.12740648
119Pathways in cancer_Homo sapiens_hsa052000.11605445
120VEGF signaling pathway_Homo sapiens_hsa043700.10947714
121Melanoma_Homo sapiens_hsa052180.10697114
122p53 signaling pathway_Homo sapiens_hsa041150.10270974
123Basal cell carcinoma_Homo sapiens_hsa052170.10146270
124Cholinergic synapse_Homo sapiens_hsa047250.10088020
125Wnt signaling pathway_Homo sapiens_hsa043100.09867051
126Melanogenesis_Homo sapiens_hsa049160.09788988
127AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.08739593

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