NF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)3.80939502
2regulation of short-term neuronal synaptic plasticity (GO:0048172)3.78841268
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.31897558
4synaptic vesicle maturation (GO:0016188)3.31449090
5cerebellar Purkinje cell differentiation (GO:0021702)3.26588027
6vocalization behavior (GO:0071625)3.26131643
7embryonic retina morphogenesis in camera-type eye (GO:0060059)3.24889334
8dendrite morphogenesis (GO:0048813)3.15947729
9glutamate secretion (GO:0014047)3.13418188
10regulation of protein polyubiquitination (GO:1902914)3.12336735
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.10848417
12neuron cell-cell adhesion (GO:0007158)3.09539995
13establishment of nucleus localization (GO:0040023)3.09327835
14synaptic vesicle endocytosis (GO:0048488)3.07822335
15regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06450624
16nuclear pore complex assembly (GO:0051292)3.05468985
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04094511
18axonal fasciculation (GO:0007413)3.03392088
19presynaptic membrane assembly (GO:0097105)3.03195780
20dendritic spine morphogenesis (GO:0060997)3.00754368
21interkinetic nuclear migration (GO:0022027)2.99954087
22synaptic vesicle docking involved in exocytosis (GO:0016081)2.99339286
23regulation of synaptic vesicle exocytosis (GO:2000300)2.97840219
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.96644935
25regulation of glutamate receptor signaling pathway (GO:1900449)2.92057313
26synaptic vesicle exocytosis (GO:0016079)2.91922290
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.88496767
28protein localization to synapse (GO:0035418)2.80745652
29embryonic foregut morphogenesis (GO:0048617)2.79626370
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77801084
31presynaptic membrane organization (GO:0097090)2.76843779
32ionotropic glutamate receptor signaling pathway (GO:0035235)2.76199505
33mitotic sister chromatid cohesion (GO:0007064)2.75673535
34negative regulation of keratinocyte proliferation (GO:0010839)2.74932853
35proline transport (GO:0015824)2.74516495
36L-amino acid import (GO:0043092)2.73482906
37cell migration in hindbrain (GO:0021535)2.72769364
38gamma-aminobutyric acid transport (GO:0015812)2.70110562
39neurotransmitter-gated ion channel clustering (GO:0072578)2.69378820
40nuclear pore organization (GO:0006999)2.68744083
41lipid translocation (GO:0034204)2.68044218
42phospholipid translocation (GO:0045332)2.68044218
43neuron recognition (GO:0008038)2.66601303
44layer formation in cerebral cortex (GO:0021819)2.65846458
45innervation (GO:0060384)2.64913711
46cellular potassium ion homeostasis (GO:0030007)2.62720470
47Golgi to endosome transport (GO:0006895)2.61643671
48genitalia morphogenesis (GO:0035112)2.60403788
49artery development (GO:0060840)2.59387033
50exploration behavior (GO:0035640)2.58484575
51nerve growth factor signaling pathway (GO:0038180)2.57515148
52regulation of NFAT protein import into nucleus (GO:0051532)2.55305724
53regulation of synaptic vesicle transport (GO:1902803)2.54638687
54neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.54012898
55pericardium development (GO:0060039)2.53613077
56response to auditory stimulus (GO:0010996)2.53348086
57morphogenesis of an epithelial sheet (GO:0002011)2.53339146
58negative regulation of cytosolic calcium ion concentration (GO:0051481)2.52981616
59central nervous system projection neuron axonogenesis (GO:0021952)2.52421870
60synaptic transmission, glutamatergic (GO:0035249)2.52058980
61postsynaptic membrane organization (GO:0001941)2.51390398
62neurotransmitter secretion (GO:0007269)2.51285929
63neuromuscular process controlling balance (GO:0050885)2.48605496
64glutamate receptor signaling pathway (GO:0007215)2.46989929
65vesicle transport along microtubule (GO:0047496)2.46918943
66cerebellar granule cell differentiation (GO:0021707)2.45956299
67* regulation of neuronal synaptic plasticity (GO:0048168)2.45479661
68neuronal action potential propagation (GO:0019227)2.44416528
69regulation of respiratory system process (GO:0044065)2.44063530
70apical protein localization (GO:0045176)2.43863809
71nucleus localization (GO:0051647)2.42947255
72regulation of dendritic spine morphogenesis (GO:0061001)2.42781736
73regulation of excitatory postsynaptic membrane potential (GO:0060079)2.42406709
74insulin-like growth factor receptor signaling pathway (GO:0048009)2.41744381
75gastrulation with mouth forming second (GO:0001702)2.41721067
76cytoskeletal anchoring at plasma membrane (GO:0007016)2.41585392
77cell communication by electrical coupling (GO:0010644)2.41061986
78startle response (GO:0001964)2.40982624
79appendage development (GO:0048736)2.40108936
80limb development (GO:0060173)2.40108936
81neuron-neuron synaptic transmission (GO:0007270)2.39684827
82auditory behavior (GO:0031223)2.37863570
83regulation of postsynaptic membrane potential (GO:0060078)2.37834220
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.37517069
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.37420350
86regulation of axon extension involved in axon guidance (GO:0048841)2.36686883
87negative regulation of hormone biosynthetic process (GO:0032353)2.35448631
88regulation of cAMP-dependent protein kinase activity (GO:2000479)2.34847998
89membrane depolarization during action potential (GO:0086010)2.34213110
90neuromuscular process (GO:0050905)2.34208639
91negative regulation of dendrite development (GO:2000171)2.33502476
92regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.33383580
93regulation of hippo signaling (GO:0035330)2.33034924
94NLS-bearing protein import into nucleus (GO:0006607)2.32963060
95cytoplasmic mRNA processing body assembly (GO:0033962)2.32521553
96asymmetric protein localization (GO:0008105)2.32451944
97regulation of transforming growth factor beta2 production (GO:0032909)2.32143381
98dendritic spine organization (GO:0097061)2.27568997
99phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.27390624
100monoubiquitinated protein deubiquitination (GO:0035520)2.26509412
101amino acid import (GO:0043090)2.26285513
102* regulation of long-term neuronal synaptic plasticity (GO:0048169)2.23063835
103central nervous system neuron axonogenesis (GO:0021955)2.22875252
104sodium ion export (GO:0071436)2.22397837
105positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.22394663
106positive regulation of dendritic spine morphogenesis (GO:0061003)2.22149906
107embryonic camera-type eye morphogenesis (GO:0048596)2.21870564
108paraxial mesoderm development (GO:0048339)2.21440610
109protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.21184141
110synapse assembly (GO:0007416)2.20759699
111protein targeting to Golgi (GO:0000042)2.20179043
112regulation of axon guidance (GO:1902667)2.20175305
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.19070650
114transmission of nerve impulse (GO:0019226)2.18880427
115negative regulation of dendrite morphogenesis (GO:0050774)2.18669363
116membrane hyperpolarization (GO:0060081)2.17709281
117cell differentiation in hindbrain (GO:0021533)2.17615868
118long-term synaptic potentiation (GO:0060291)2.16990405
119membrane assembly (GO:0071709)2.16920348
120establishment of protein localization to Golgi (GO:0072600)2.16889207
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.16807536
122dorsal/ventral axis specification (GO:0009950)2.16349837
123retina layer formation (GO:0010842)2.16316201
124regulation of synapse structural plasticity (GO:0051823)2.16213536
125activation of protein kinase A activity (GO:0034199)2.15765889
126adult walking behavior (GO:0007628)2.15305185
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.15251620
128regulation of respiratory gaseous exchange (GO:0043576)2.14694337
129long-term memory (GO:0007616)2.13963556
130suckling behavior (GO:0001967)2.13948122
131alanine transport (GO:0032328)2.13326106
132glycine transport (GO:0015816)2.13170232
133retrograde transport, vesicle recycling within Golgi (GO:0000301)2.13095903
134organelle transport along microtubule (GO:0072384)2.13062010
135desmosome organization (GO:0002934)2.11958030
136negative regulation of Rho protein signal transduction (GO:0035024)2.10867734
137myotube differentiation (GO:0014902)2.08324880
138* cerebral cortex development (GO:0021987)2.07548360
139pore complex assembly (GO:0046931)2.03318030
140early endosome to late endosome transport (GO:0045022)2.00784050
141heart morphogenesis (GO:0003007)2.00664138
142notochord development (GO:0030903)2.00204448
143positive regulation of neurological system process (GO:0031646)1.99276548
144negative regulation of hormone metabolic process (GO:0032351)1.98516615
145coronary vasculature morphogenesis (GO:0060977)1.98049164
146negative regulation of translation, ncRNA-mediated (GO:0040033)1.97949515
147regulation of translation, ncRNA-mediated (GO:0045974)1.97949515
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)1.97949515
149hippo signaling (GO:0035329)1.95655309
150cell communication involved in cardiac conduction (GO:0086065)1.95539391
151eye photoreceptor cell differentiation (GO:0001754)1.93772902
152photoreceptor cell differentiation (GO:0046530)1.93772902
153pre-miRNA processing (GO:0031054)1.93679540
154regulation of clathrin-mediated endocytosis (GO:2000369)1.92074091
155myoblast fusion (GO:0007520)1.92023086
156positive regulation of calcium ion transmembrane transporter activity (GO:1901021)1.90819499
157negative regulation of DNA repair (GO:0045738)1.90807574
158negative regulation of vascular permeability (GO:0043116)1.90735564
159righting reflex (GO:0060013)1.90319692
160import into cell (GO:0098657)1.89462252
161centrosome duplication (GO:0051298)1.89216998
162regulation of keratinocyte proliferation (GO:0010837)1.88896414
163ectodermal placode formation (GO:0060788)1.88356985
164microtubule anchoring (GO:0034453)1.87600010
165positive regulation of transcription from RNA polymerase III promoter (GO:0045945)1.86668396
166nephron tubule formation (GO:0072079)1.85766999

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.68839455
2GBX2_23144817_ChIP-Seq_PC3_Human3.56745136
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.73254598
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47409067
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10089702
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09442695
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08906587
8AR_21572438_ChIP-Seq_LNCaP_Human1.98767314
9JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93962648
10* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93543923
11DROSHA_22980978_ChIP-Seq_HELA_Human1.90569635
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.90525781
13EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85937530
14RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85937530
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85932319
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82441500
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79293587
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77446919
19SMAD4_21799915_ChIP-Seq_A2780_Human1.77416788
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.76231141
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.76197066
22RNF2_27304074_Chip-Seq_ESCs_Mouse1.75847704
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75305401
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.74497124
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72603222
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69745394
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.68940042
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.68531020
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67907043
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.66913267
31* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65701012
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63863301
33* STAT3_23295773_ChIP-Seq_U87_Human1.57995705
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57246394
35AHR_22903824_ChIP-Seq_MCF-7_Human1.56971863
36SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56453910
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54383935
38* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.52244948
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.49770439
40* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49708406
41P300_19829295_ChIP-Seq_ESCs_Human1.48482819
42REST_21632747_ChIP-Seq_MESCs_Mouse1.45480065
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43968497
44TP53_16413492_ChIP-PET_HCT116_Human1.43505628
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.42726033
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42596820
47* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42592591
48* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42222670
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41217617
50* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41171264
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40241053
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38862246
53IGF1R_20145208_ChIP-Seq_DFB_Human1.38720533
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.38325001
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37835740
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37835740
57* TCF4_23295773_ChIP-Seq_U87_Human1.37703730
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36904076
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35480472
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.34120471
61WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33952616
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32662468
63EZH2_27294783_Chip-Seq_ESCs_Mouse1.32655886
64FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32577455
65* SOX2_21211035_ChIP-Seq_LN229_Gbm1.30989823
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30306095
67EWS_26573619_Chip-Seq_HEK293_Human1.29969786
68TAF15_26573619_Chip-Seq_HEK293_Human1.28414018
69* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26748610
70* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26510296
71AR_19668381_ChIP-Seq_PC3_Human1.26408057
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25869097
73CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25810291
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.23645855
75* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23241271
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22617848
77AR_25329375_ChIP-Seq_VCAP_Human1.21137693
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19119293
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.18953526
80CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.18375987
81FUS_26573619_Chip-Seq_HEK293_Human1.17192686
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.16897449
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16605353
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.16182075
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16077922
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16077922
87FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14808956
88TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14318963
89* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13742257
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.13710635
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13413095
92* CJUN_26792858_Chip-Seq_BT549_Human1.13286845
93CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12787019
94EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10967334
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10961179
96* CBP_20019798_ChIP-Seq_JUKART_Human1.10723391
97* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10723391
98NANOG_18555785_Chip-Seq_ESCs_Mouse1.10580589
99BCAT_22108803_ChIP-Seq_LS180_Human1.10223361
100SMAD3_21741376_ChIP-Seq_HESCs_Human1.09479655
101* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09308448
102GATA1_22025678_ChIP-Seq_K562_Human1.09169197
103ZNF274_21170338_ChIP-Seq_K562_Hela1.08705320
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08345249
105* SOX9_26525672_Chip-Seq_HEART_Mouse1.07855589
106FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06635734
107* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06575029
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06350196
109PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05632401
110RUNX2_22187159_ChIP-Seq_PCA_Human1.05436284
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.05121494
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.04895530
113* KDM2B_26808549_Chip-Seq_REH_Human1.04200909
114ER_23166858_ChIP-Seq_MCF-7_Human1.03366772
115TP53_18474530_ChIP-ChIP_U2OS_Human1.03050022
116TRIM28_21343339_ChIP-Seq_HEK293_Human1.02478639
117* ISL1_27105846_Chip-Seq_CPCs_Mouse1.02013507
118RNF2_27304074_Chip-Seq_NSC_Mouse1.01941728
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01898012
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01362549
121WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00582257
122* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99753474
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99329600
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.98994271
125RXR_22108803_ChIP-Seq_LS180_Human0.98984924
126P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98875745
127SMAD4_21741376_ChIP-Seq_HESCs_Human0.98367004
128* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98305536
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.98271704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.14847949
2MP0004859_abnormal_synaptic_plasticity3.97376769
3MP0005171_absent_coat_pigmentation3.40114650
4MP0009046_muscle_twitch2.95120614
5MP0008057_abnormal_DNA_replication2.64957329
6MP0004270_analgesia2.61454348
7MP0009780_abnormal_chondrocyte_physiolo2.57487792
8MP0003635_abnormal_synaptic_transmissio2.56936691
9MP0003880_abnormal_central_pattern2.35348441
10* MP0002063_abnormal_learning/memory/cond2.17625655
11MP0000778_abnormal_nervous_system2.12142207
12MP0005187_abnormal_penis_morphology2.11484398
13MP0001299_abnormal_eye_distance/2.09734008
14* MP0002064_seizures1.96929813
15MP0001486_abnormal_startle_reflex1.95158653
16MP0000383_abnormal_hair_follicle1.94608485
17MP0002572_abnormal_emotion/affect_behav1.93711836
18MP0009745_abnormal_behavioral_response1.93018240
19MP0010352_gastrointestinal_tract_polyps1.83913443
20MP0010678_abnormal_skin_adnexa1.82116923
21MP0003787_abnormal_imprinting1.78240338
22MP0003122_maternal_imprinting1.75436645
23MP0002272_abnormal_nervous_system1.72682009
24MP0002734_abnormal_mechanical_nocicepti1.72672999
25MP0004858_abnormal_nervous_system1.68748390
26MP0000427_abnormal_hair_cycle1.63283393
27MP0005503_abnormal_tendon_morphology1.62682219
28MP0005409_darkened_coat_color1.62111250
29MP0000537_abnormal_urethra_morphology1.58502790
30MP0004233_abnormal_muscle_weight1.55690154
31MP0004885_abnormal_endolymph1.52656366
32MP0005423_abnormal_somatic_nervous1.50291823
33MP0002067_abnormal_sensory_capabilities1.49612546
34MP0002009_preneoplasia1.49567772
35* MP0003937_abnormal_limbs/digits/tail_de1.49547424
36MP0002184_abnormal_innervation1.46934651
37MP0000955_abnormal_spinal_cord1.46635803
38MP0001177_atelectasis1.44325663
39MP0005623_abnormal_meninges_morphology1.43008437
40MP0010234_abnormal_vibrissa_follicle1.40145963
41MP0005551_abnormal_eye_electrophysiolog1.39694157
42MP0003950_abnormal_plasma_membrane1.38253368
43MP0004811_abnormal_neuron_physiology1.37404934
44MP0005275_abnormal_skin_tensile1.35189627
45* MP0002882_abnormal_neuron_morphology1.35043214
46MP0008569_lethality_at_weaning1.35020798
47* MP0003634_abnormal_glial_cell1.27700889
48MP0002557_abnormal_social/conspecific_i1.25283517
49MP0001968_abnormal_touch/_nociception1.25179148
50MP0003941_abnormal_skin_development1.23498412
51* MP0002108_abnormal_muscle_morphology1.21877696
52* MP0003690_abnormal_glial_cell1.21585365
53MP0003283_abnormal_digestive_organ1.20872738
54MP0000579_abnormal_nail_morphology1.18367533
55MP0003385_abnormal_body_wall1.16731264
56MP0003755_abnormal_palate_morphology1.15741844
57MP0000751_myopathy1.15537422
58* MP0005386_behavior/neurological_phenoty1.15475573
59* MP0004924_abnormal_behavior1.15475573
60MP0001984_abnormal_olfaction1.14461983
61* MP0003633_abnormal_nervous_system1.14176151
62MP0008438_abnormal_cutaneous_collagen1.14118503
63* MP0002152_abnormal_brain_morphology1.13392227
64* MP0005646_abnormal_pituitary_gland1.11906545
65MP0003890_abnormal_embryonic-extraembry1.11827480
66MP0001440_abnormal_grooming_behavior1.10258230
67MP0001501_abnormal_sleep_pattern1.07923164
68MP0009250_abnormal_appendicular_skeleto1.07649208
69MP0005253_abnormal_eye_physiology1.07601709
70MP0000647_abnormal_sebaceous_gland1.07137053
71MP0000534_abnormal_ureter_morphology1.06837989
72MP0004272_abnormal_basement_membrane1.05746069
73MP0005248_abnormal_Harderian_gland1.05489652
74* MP0003631_nervous_system_phenotype1.02368837
75* MP0003935_abnormal_craniofacial_develop1.02314578
76* MP0003045_fibrosis1.01790310
77MP0008877_abnormal_DNA_methylation1.01367748
78MP0002735_abnormal_chemical_nociception1.00536379
79MP0002233_abnormal_nose_morphology1.00499625
80MP0010030_abnormal_orbit_morphology1.00343196
81MP0003632_abnormal_nervous_system0.98819831
82MP0001502_abnormal_circadian_rhythm0.98216679
83MP0003121_genomic_imprinting0.97569827
84MP0002733_abnormal_thermal_nociception0.96455465
85* MP0002066_abnormal_motor_capabilities/c0.96395417
86MP0001970_abnormal_pain_threshold0.96255352
87MP0004742_abnormal_vestibular_system0.95857734
88* MP0004134_abnormal_chest_morphology0.94860959
89MP0002116_abnormal_craniofacial_bone0.93183048
90MP0005076_abnormal_cell_differentiation0.92382704
91MP0005174_abnormal_tail_pigmentation0.91608941
92* MP0000920_abnormal_myelination0.91513950
93* MP0003861_abnormal_nervous_system0.90796852
94MP0002896_abnormal_bone_mineralization0.89557514
95MP0001958_emphysema0.89263248
96MP0004084_abnormal_cardiac_muscle0.89092206
97MP0004145_abnormal_muscle_electrophysio0.88486376
98MP0002084_abnormal_developmental_patter0.87894921
99* MP0000631_abnormal_neuroendocrine_gland0.87556516
100MP0002938_white_spotting0.85096879
101MP0010368_abnormal_lymphatic_system0.85004115
102MP0000428_abnormal_craniofacial_morphol0.84664669
103MP0001188_hyperpigmentation0.84276391
104* MP0002229_neurodegeneration0.81990031
105MP0002109_abnormal_limb_morphology0.81934424
106MP0002234_abnormal_pharynx_morphology0.81681965
107MP0003195_calcinosis0.80924117
108MP0000566_synostosis0.80171487
109MP0002909_abnormal_adrenal_gland0.79423417
110* MP0002752_abnormal_somatic_nervous0.79237594
111* MP0001943_abnormal_respiration0.78901525
112MP0004142_abnormal_muscle_tone0.78809086
113MP0000377_abnormal_hair_follicle0.78504923
114MP0000762_abnormal_tongue_morphology0.78395037
115MP0003868_abnormal_feces_composition0.77886926
116MP0003705_abnormal_hypodermis_morpholog0.77761771
117MP0004043_abnormal_pH_regulation0.77261205
118MP0000013_abnormal_adipose_tissue0.76768750
119* MP0003942_abnormal_urinary_system0.76471619
120* MP0005645_abnormal_hypothalamus_physiol0.76384482
121MP0003115_abnormal_respiratory_system0.74733774
122MP0001963_abnormal_hearing_physiology0.74240967
123MP0006072_abnormal_retinal_apoptosis0.74201041
124MP0002282_abnormal_trachea_morphology0.74118209
125MP0009697_abnormal_copulation0.73816961
126MP0002249_abnormal_larynx_morphology0.73790510
127MP0010386_abnormal_urinary_bladder0.73058875
128* MP0002081_perinatal_lethality0.72457622
129* MP0002697_abnormal_eye_size0.72362104
130MP0000462_abnormal_digestive_system0.71926735
131MP0009703_decreased_birth_body0.71750753
132MP0003091_abnormal_cell_migration0.71589697
133MP0004215_abnormal_myocardial_fiber0.71333539
134MP0005367_renal/urinary_system_phenotyp0.70999781
135MP0000516_abnormal_urinary_system0.70999781
136MP0000015_abnormal_ear_pigmentation0.70864073
137* MP0000432_abnormal_head_morphology0.69977686
138MP0003137_abnormal_impulse_conducting0.69548327

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.64375027
2Febrile seizures (HP:0002373)3.10773388
3Action tremor (HP:0002345)3.09100819
4Epileptic encephalopathy (HP:0200134)3.06509451
5Focal seizures (HP:0007359)2.99669562
6Atonic seizures (HP:0010819)2.80122909
7Aplasia involving bones of the upper limbs (HP:0009823)2.67274481
8Aplasia of the phalanges of the hand (HP:0009802)2.67274481
9Aplasia involving bones of the extremities (HP:0009825)2.67274481
10Turricephaly (HP:0000262)2.58169104
11Progressive cerebellar ataxia (HP:0002073)2.54180265
12Coronal craniosynostosis (HP:0004440)2.51498045
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.49794797
14Short 4th metacarpal (HP:0010044)2.49794797
15Dysmetric saccades (HP:0000641)2.47886152
16Urinary bladder sphincter dysfunction (HP:0002839)2.43899966
17Termporal pattern (HP:0011008)2.42787652
18Insidious onset (HP:0003587)2.42787652
19Alacrima (HP:0000522)2.38322052
20Myokymia (HP:0002411)2.33844245
21Drooling (HP:0002307)2.24520193
22Excessive salivation (HP:0003781)2.24520193
23Narrow nasal bridge (HP:0000446)2.19470704
24Blue irides (HP:0000635)2.18975703
25Genetic anticipation (HP:0003743)2.17554941
26Hypoplastic labia majora (HP:0000059)2.17288301
27Abnormality of the epiphyses of the hand (HP:0005924)2.17269619
28Deep philtrum (HP:0002002)2.16083040
29Papillary thyroid carcinoma (HP:0002895)2.15574941
30Decreased lacrimation (HP:0000633)2.10588282
31Anteriorly placed anus (HP:0001545)2.10524402
32Gaze-evoked nystagmus (HP:0000640)2.07831948
33Truncal obesity (HP:0001956)2.06437629
34Trigonocephaly (HP:0000243)2.05724595
35Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.03589867
36Narrow palate (HP:0000189)2.02866351
37Absence seizures (HP:0002121)2.02696754
38Fair hair (HP:0002286)2.02110156
39Arterial tortuosity (HP:0005116)1.99920359
40Abnormality of the labia majora (HP:0012881)1.96361694
41Shallow orbits (HP:0000586)1.95485114
42Abnormality of the corticospinal tract (HP:0002492)1.95121964
43Bell-shaped thorax (HP:0001591)1.94645259
44Dysdiadochokinesis (HP:0002075)1.94358729
45Hypopigmentation of the fundus (HP:0007894)1.93524287
46* Aqueductal stenosis (HP:0002410)1.92420035
47Chronic hepatic failure (HP:0100626)1.91119424
48Absent speech (HP:0001344)1.89377448
49Cerebral aneurysm (HP:0004944)1.87580022
50* Abnormality of the nasal septum (HP:0000419)1.86136014
51Hyperventilation (HP:0002883)1.83814402
52* Macroorchidism (HP:0000053)1.82654190
53Abnormality of incisor morphology (HP:0011063)1.81376649
54Impaired vibration sensation in the lower limbs (HP:0002166)1.80312585
55Postural instability (HP:0002172)1.79788489
56Vascular tortuosity (HP:0004948)1.79326736
57Abnormality of the 4th metacarpal (HP:0010012)1.78942516
58Abnormality of the ischium (HP:0003174)1.78668354
59Widely spaced teeth (HP:0000687)1.78404646
60Generalized hypopigmentation of hair (HP:0011358)1.77852573
61Absent frontal sinuses (HP:0002688)1.77778106
62Hypoplastic ischia (HP:0003175)1.77057923
63Urethral obstruction (HP:0000796)1.77037664
64Truncal ataxia (HP:0002078)1.76153794
65Broad-based gait (HP:0002136)1.75321012
66Volvulus (HP:0002580)1.74914103
67Smooth philtrum (HP:0000319)1.74405343
68Degeneration of the lateral corticospinal tracts (HP:0002314)1.74397191
69Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.74397191
70Curly hair (HP:0002212)1.74103498
71Exotropia (HP:0000577)1.73262922
72Lip pit (HP:0100267)1.72554315
73Dialeptic seizures (HP:0011146)1.72268372
74Cutaneous finger syndactyly (HP:0010554)1.71567599
75Neoplasm of the heart (HP:0100544)1.70131741
76Chromsome breakage (HP:0040012)1.69658882
77* Overgrowth (HP:0001548)1.69503516
78Thickened helices (HP:0000391)1.69106285
79Thyroid carcinoma (HP:0002890)1.68246826
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68097808
81Vertebral arch anomaly (HP:0008438)1.68091770
82Sandal gap (HP:0001852)1.67456577
83Renovascular hypertension (HP:0100817)1.66743371
84Submucous cleft hard palate (HP:0000176)1.66457324
85Neonatal short-limb short stature (HP:0008921)1.66365894
86Laryngomalacia (HP:0001601)1.66299957
87Generalized tonic-clonic seizures (HP:0002069)1.65854660
88Increased number of teeth (HP:0011069)1.65050238
89Tubulointerstitial nephritis (HP:0001970)1.63849704
90Chorioretinal atrophy (HP:0000533)1.63455776
91Heterotopia (HP:0002282)1.63281173
92Bronchomalacia (HP:0002780)1.62921625
93Thick eyebrow (HP:0000574)1.62761519
94Open mouth (HP:0000194)1.62702760
95Intention tremor (HP:0002080)1.62457484
96Preaxial foot polydactyly (HP:0001841)1.62033580
97Progressive sensorineural hearing impairment (HP:0000408)1.61904598
98Fetal akinesia sequence (HP:0001989)1.61782555
99Tracheomalacia (HP:0002779)1.61773500
100Broad thumb (HP:0011304)1.61512231
101Intestinal fistula (HP:0100819)1.60389312
102Hemiplegia (HP:0002301)1.59791089
103Dysmetria (HP:0001310)1.59432923
104Hyperkalemia (HP:0002153)1.59226100
105Hepatoblastoma (HP:0002884)1.59175518
106Mild short stature (HP:0003502)1.59155298
107Wide anterior fontanel (HP:0000260)1.58659630
108Annular pancreas (HP:0001734)1.58478337
109Hypoplasia of the maxilla (HP:0000327)1.58238632
110Abnormality of the labia minora (HP:0012880)1.58136314
111Morphological abnormality of the middle ear (HP:0008609)1.58125605
112Ankle clonus (HP:0011448)1.57466951
113Obsessive-compulsive behavior (HP:0000722)1.57214138
114Aortic dissection (HP:0002647)1.57130893
115Cutaneous syndactyly (HP:0012725)1.55135926
116Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54288929
117* Midline defect of the nose (HP:0004122)1.54099315
118Right ventricular cardiomyopathy (HP:0011663)1.53765857
119Broad metatarsal (HP:0001783)1.53166438
120Vitreoretinal degeneration (HP:0000655)1.52978448
121Abnormality of the distal phalanx of the thumb (HP:0009617)1.52503789
122Short chin (HP:0000331)1.52215120
123Chromosomal breakage induced by crosslinking agents (HP:0003221)1.51604537
124Abnormality of salivation (HP:0100755)1.50970477
125Sparse lateral eyebrow (HP:0005338)1.49657332
126Aortic aneurysm (HP:0004942)1.49014139
127Shawl scrotum (HP:0000049)1.48623453
128Acute myeloid leukemia (HP:0004808)1.48461438
129Deeply set eye (HP:0000490)1.48266968
130Spastic gait (HP:0002064)1.47955636
131Abnormality of the lower motor neuron (HP:0002366)1.47493253
132High anterior hairline (HP:0009890)1.45776274
133Germ cell neoplasia (HP:0100728)1.45362670
134Megalencephaly (HP:0001355)1.44674078
135Intellectual disability, moderate (HP:0002342)1.44472181
136Long nose (HP:0003189)1.42794311
137Limited hip movement (HP:0008800)1.42684336
138Fibular hypoplasia (HP:0003038)1.41789489
139Supranuclear gaze palsy (HP:0000605)1.41597958
140Central scotoma (HP:0000603)1.41450312
141Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.41429082
142Short metatarsal (HP:0010743)1.41382540
143Mitral valve prolapse (HP:0001634)1.41251142
144Scanning speech (HP:0002168)1.41199835
145Hemiparesis (HP:0001269)1.40132051
146Subacute progressive viral hepatitis (HP:0006572)1.39513294
147Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.39413230
148Broad long bones (HP:0005622)1.39169967
149Ectopic kidney (HP:0000086)1.39091197
150Protruding tongue (HP:0010808)1.38221425
151Decreased motor nerve conduction velocity (HP:0003431)1.37554184
152Tapered finger (HP:0001182)1.37485302
153Tracheal stenosis (HP:0002777)1.37450241
154Bifid tongue (HP:0010297)1.37428762
155Dental malocclusion (HP:0000689)1.37047058
156Cystic hygroma (HP:0000476)1.36153070
157Neoplasm of the oral cavity (HP:0100649)1.35873814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.19784674
2LATS13.44591283
3PNCK2.76783153
4NTRK32.64927905
5CASK2.31425750
6ICK2.28460555
7DDR22.26740152
8AKT32.26340105
9MAP3K42.22354159
10EPHA41.98760149
11BRD41.92773330
12MET1.90216687
13STK38L1.89865398
14CAMK1G1.88293739
15SGK21.85300078
16PRKD31.83353217
17MARK11.82998877
18FGFR21.70734114
19CAMK1D1.63432738
20SGK31.63009787
21NTRK21.61418357
22SGK2231.56578568
23SGK4941.56578568
24EEF2K1.55006657
25STK241.53474098
26TYRO31.51525357
27MAP3K91.50653244
28NUAK11.47808631
29MAP2K71.46657766
30PDGFRA1.41114138
31PAK61.37098114
32WNK11.34474450
33MST1R1.32043259
34MKNK21.31521573
35BRSK21.26101450
36PINK11.20541532
37DAPK21.15639365
38MINK11.13879548
39LMTK21.11757582
40UHMK11.10726009
41FRK1.10659589
42CDK121.10372260
43YES11.07465356
44BMPR1B1.05975934
45NEK61.03498181
46PLK21.02747120
47NTRK11.02591839
48MAP3K61.02578708
49MAPK130.98865497
50CDC42BPA0.97566850
51SGK10.97227254
52KSR10.96679212
53STK30.94249705
54ACVR1B0.94081665
55PRKCH0.93442167
56CDK50.93143275
57PHKG20.92775539
58PHKG10.92775539
59BMX0.91991312
60STK390.90750557
61PDGFRB0.90235138
62PKN20.90050846
63ERBB30.87706779
64DMPK0.85133624
65WNK40.84405017
66SIK10.84351122
67BCR0.83236060
68RIPK10.83209909
69STK380.81368257
70PTK20.80031058
71LATS20.79033314
72SCYL20.78152768
73NEK90.75261450
74DAPK10.74926695
75FGR0.74527429
76MAP3K70.72277468
77MELK0.71763344
78CAMK2A0.69953222
79NLK0.68244954
80EPHB20.67754383
81PAK30.67509125
82FGFR10.67134251
83PRKAA20.66595500
84OXSR10.66287455
85MAP2K40.65805706
86WNK30.65805322
87MARK20.64385516
88CAMKK10.63963083
89INSRR0.63220595
90MAPK150.61397875
91MKNK10.61204474
92MAPK100.60771901
93ERBB20.60328655
94PRKAA10.59426492
95ERBB40.59154758
96ROCK10.58356067
97WEE10.56822367
98CAMK10.56094925
99MTOR0.55584911
100RPS6KA30.55178735
101RET0.55100766
102PRKCG0.54626509
103PRKCE0.54501375
104CDK30.52542954
105PKN10.52362286
106ATM0.50774498
107FGFR30.50652518
108TNIK0.50647685
109PIK3CA0.49850392
110EPHA30.49775174
111MAP3K20.48663576
112STK110.48146480
113FER0.47048440
114CAMK40.46590816
115RPS6KB20.46099405
116RPS6KB10.45272949
117GSK3B0.45018640
118CSNK1D0.44942020
119CAMK2B0.43958924
120CSNK1A1L0.43458244
121GSK3A0.42865769
122PRKCZ0.41187127
123CSNK1E0.40840643
124TRPM70.40217377
125FLT30.39865402
126PAK20.39752618
127MAP2K10.39298238
128PRKD20.39047272
129SIK20.38708803
130* MAPK80.38345395
131RPS6KA20.38243815

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.33004587
2GABAergic synapse_Homo sapiens_hsa047271.92530069
3Synaptic vesicle cycle_Homo sapiens_hsa047211.87703203
4Circadian entrainment_Homo sapiens_hsa047131.86053115
5Olfactory transduction_Homo sapiens_hsa047401.86001878
6Fatty acid biosynthesis_Homo sapiens_hsa000611.77544101
7Morphine addiction_Homo sapiens_hsa050321.76714663
8Glutamatergic synapse_Homo sapiens_hsa047241.76618697
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69635664
10Long-term potentiation_Homo sapiens_hsa047201.60912307
11Dorso-ventral axis formation_Homo sapiens_hsa043201.58155417
12Salivary secretion_Homo sapiens_hsa049701.56493118
13Axon guidance_Homo sapiens_hsa043601.51244448
14Amphetamine addiction_Homo sapiens_hsa050311.50120781
15Insulin secretion_Homo sapiens_hsa049111.48677881
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47893445
17Dopaminergic synapse_Homo sapiens_hsa047281.45361148
18Renin secretion_Homo sapiens_hsa049241.44881230
19Cholinergic synapse_Homo sapiens_hsa047251.41802670
20Phototransduction_Homo sapiens_hsa047441.40575195
21ErbB signaling pathway_Homo sapiens_hsa040121.36909167
22Type II diabetes mellitus_Homo sapiens_hsa049301.35619062
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35597425
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28603239
25Gastric acid secretion_Homo sapiens_hsa049711.26684815
26Long-term depression_Homo sapiens_hsa047301.26043531
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25014551
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24456286
29Gap junction_Homo sapiens_hsa045401.22713820
30Taste transduction_Homo sapiens_hsa047421.22422512
31Cocaine addiction_Homo sapiens_hsa050301.22083545
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.21249450
33ABC transporters_Homo sapiens_hsa020101.20909456
34Glioma_Homo sapiens_hsa052141.19864144
35cAMP signaling pathway_Homo sapiens_hsa040241.18458689
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18030913
37Serotonergic synapse_Homo sapiens_hsa047261.16505912
38Hedgehog signaling pathway_Homo sapiens_hsa043401.16191902
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15578964
40Endometrial cancer_Homo sapiens_hsa052131.11793643
41GnRH signaling pathway_Homo sapiens_hsa049121.11597052
42Oxytocin signaling pathway_Homo sapiens_hsa049211.11036848
43mTOR signaling pathway_Homo sapiens_hsa041501.09546482
44Dilated cardiomyopathy_Homo sapiens_hsa054141.08269099
45Estrogen signaling pathway_Homo sapiens_hsa049151.07527696
46Basal cell carcinoma_Homo sapiens_hsa052171.07006684
47Melanogenesis_Homo sapiens_hsa049161.06045315
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05580194
49Thyroid hormone signaling pathway_Homo sapiens_hsa049191.04807180
50Wnt signaling pathway_Homo sapiens_hsa043101.04227777
51Adherens junction_Homo sapiens_hsa045201.03520513
52Hippo signaling pathway_Homo sapiens_hsa043901.00867631
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.00471219
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00022352
55Calcium signaling pathway_Homo sapiens_hsa040200.98869912
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.98567205
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97538743
58Pancreatic secretion_Homo sapiens_hsa049720.94393679
59Focal adhesion_Homo sapiens_hsa045100.92613671
60Choline metabolism in cancer_Homo sapiens_hsa052310.90431615
61Nitrogen metabolism_Homo sapiens_hsa009100.89679520
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88202064
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87213152
64Protein digestion and absorption_Homo sapiens_hsa049740.86516071
65* MAPK signaling pathway_Homo sapiens_hsa040100.86430005
66Thyroid cancer_Homo sapiens_hsa052160.84723719
67Proteoglycans in cancer_Homo sapiens_hsa052050.82521593
68Bile secretion_Homo sapiens_hsa049760.82236109
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.82205691
70Prolactin signaling pathway_Homo sapiens_hsa049170.80642289
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.79180415
72Colorectal cancer_Homo sapiens_hsa052100.79005058
73Lysine degradation_Homo sapiens_hsa003100.78921248
74Melanoma_Homo sapiens_hsa052180.78593741
75ECM-receptor interaction_Homo sapiens_hsa045120.78146064
76Rap1 signaling pathway_Homo sapiens_hsa040150.77872014
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76721612
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76550957
79Small cell lung cancer_Homo sapiens_hsa052220.75362750
80TGF-beta signaling pathway_Homo sapiens_hsa043500.74898594
81FoxO signaling pathway_Homo sapiens_hsa040680.73697164
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72240546
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72021571
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71607441
85* Ras signaling pathway_Homo sapiens_hsa040140.71543459
86Prostate cancer_Homo sapiens_hsa052150.71426555
87Thyroid hormone synthesis_Homo sapiens_hsa049180.71316322
88Circadian rhythm_Homo sapiens_hsa047100.69885277
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.69798857
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69692201
91Renal cell carcinoma_Homo sapiens_hsa052110.68725510
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67361536
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67281511
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67125162
95MicroRNAs in cancer_Homo sapiens_hsa052060.65893395
96Insulin signaling pathway_Homo sapiens_hsa049100.65796527
97Tight junction_Homo sapiens_hsa045300.64281547
98Ovarian steroidogenesis_Homo sapiens_hsa049130.64104930
99Selenocompound metabolism_Homo sapiens_hsa004500.62892849
100Pathways in cancer_Homo sapiens_hsa052000.62196289
101Inositol phosphate metabolism_Homo sapiens_hsa005620.62183360
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61188284
103Oocyte meiosis_Homo sapiens_hsa041140.60540165
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60301575
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59566059
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58048453
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58014425
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57785385
109Glucagon signaling pathway_Homo sapiens_hsa049220.57759985
110Insulin resistance_Homo sapiens_hsa049310.56942456
111Vitamin B6 metabolism_Homo sapiens_hsa007500.55764670
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.55310999
113Endocytosis_Homo sapiens_hsa041440.54917520
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.54040841
115Non-small cell lung cancer_Homo sapiens_hsa052230.52776654
116Chronic myeloid leukemia_Homo sapiens_hsa052200.52151681
117Collecting duct acid secretion_Homo sapiens_hsa049660.50872491
118AMPK signaling pathway_Homo sapiens_hsa041520.50028153
119Pancreatic cancer_Homo sapiens_hsa052120.49869371

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