ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	8.66541655
2	chromosome organization involved in meiosis (GO:0070192)	8.02144623
3	male meiosis I (GO:0007141)	7.61773864
4	synaptonemal complex assembly (GO:0007130)	7.30744926
5	DNA synthesis involved in DNA repair (GO:0000731)	6.82108011
6	meiosis I (GO:0007127)	6.47196536
7	synaptonemal complex organization (GO:0070193)	6.33560012
8	nuclear pore complex assembly (GO:0051292)	5.43977373
9	viral transcription (GO:0019083)	5.43757712
10	translational termination (GO:0006415)	5.35107621
11	resolution of meiotic recombination intermediates (GO:0000712)	5.16442153
12	DNA methylation involved in gamete generation (GO:0043046)	5.13298752
13	male meiosis (GO:0007140)	5.05236035
14	nuclear pore organization (GO:0006999)	4.90402723
15	meiotic cell cycle process (GO:1903046)	4.81839594
16	meiotic nuclear division (GO:0007126)	4.61958583
17	piRNA metabolic process (GO:0034587)	4.57888823
18	meiotic chromosome segregation (GO:0045132)	4.51680790
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.49511588
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.49312128
21	regulation of translational fidelity (GO:0006450)	4.45632095
22	proteasome assembly (GO:0043248)	4.44453404
23	cotranslational protein targeting to membrane (GO:0006613)	4.38194641
24	ribosomal small subunit biogenesis (GO:0042274)	4.38006120
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.35205028
26	translational elongation (GO:0006414)	4.34268013
27	ribosomal small subunit assembly (GO:0000028)	4.32410720
28	protein targeting to ER (GO:0045047)	4.29961917
29	cellular protein complex disassembly (GO:0043624)	4.23760786
30	translational initiation (GO:0006413)	4.19157116
31	reciprocal meiotic recombination (GO:0007131)	4.18705449
32	reciprocal DNA recombination (GO:0035825)	4.18705449
33	ribosomal large subunit biogenesis (GO:0042273)	4.17043917
34	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.15966830
35	protein localization to endoplasmic reticulum (GO:0070972)	4.10342996
36	viral life cycle (GO:0019058)	4.04478086
37	formation of translation preinitiation complex (GO:0001731)	3.97364435
38	maturation of SSU-rRNA (GO:0030490)	3.93607595
39	regulation of histone H3-K4 methylation (GO:0051569)	3.86284981
40	protein complex disassembly (GO:0043241)	3.85207691
41	pore complex assembly (GO:0046931)	3.79993534
42	mitotic chromosome condensation (GO:0007076)	3.78951952
43	macromolecular complex disassembly (GO:0032984)	3.75086448
44	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	3.74497469
45	histone H3-K9 demethylation (GO:0033169)	3.72267281
46	DNA replication checkpoint (GO:0000076)	3.69102369
47	peptidyl-arginine omega-N-methylation (GO:0035247)	3.66598629
48	sister chromatid cohesion (GO:0007062)	3.57313130
49	ATP synthesis coupled proton transport (GO:0015986)	3.51937934
50	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.51937934
51	IMP biosynthetic process (GO:0006188)	3.49956458
52	homocysteine metabolic process (GO:0050667)	3.46957326
53	CENP-A containing nucleosome assembly (GO:0034080)	3.40638155
54	gene silencing by RNA (GO:0031047)	3.40067287
55	histone exchange (GO:0043486)	3.39400796
56	ribonucleoprotein complex biogenesis (GO:0022613)	3.35583860
57	regulation of histone H3-K9 methylation (GO:0051570)	3.27622815
58	sister chromatid segregation (GO:0000819)	3.25535544
59	regulation of RNA export from nucleus (GO:0046831)	3.20897094
60	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.17721229
61	GMP metabolic process (GO:0046037)	3.17360261
62	mitotic nuclear envelope disassembly (GO:0007077)	3.16534373
63	peptidyl-arginine N-methylation (GO:0035246)	3.16360226
64	peptidyl-arginine methylation (GO:0018216)	3.16360226
65	mitotic sister chromatid segregation (GO:0000070)	3.15621299
66	purine nucleobase biosynthetic process (GO:0009113)	3.14395103
67	DNA packaging (GO:0006323)	3.12827614
68	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.12497498
69	mRNA catabolic process (GO:0006402)	3.10092378
70	chromatin remodeling at centromere (GO:0031055)	3.09922900
71	nucleobase biosynthetic process (GO:0046112)	3.05395714
72	morphogenesis of an epithelial fold (GO:0060571)	3.05303737
73	DNA topological change (GO:0006265)	3.03627468
74	seminiferous tubule development (GO:0072520)	3.02335553
75	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.02256622
76	positive regulation of histone H3-K4 methylation (GO:0051571)	2.99425197
77	peripheral nervous system neuron development (GO:0048935)	2.96472647
78	DNA replication-independent nucleosome assembly (GO:0006336)	2.93841757
79	DNA replication-independent nucleosome organization (GO:0034724)	2.93841757
80	regulation of histone methylation (GO:0031060)	2.92114458
81	protein targeting to membrane (GO:0006612)	2.90797580
82	RNA catabolic process (GO:0006401)	2.89296677
83	nuclear envelope disassembly (GO:0051081)	2.88215860
84	membrane disassembly (GO:0030397)	2.88215860
85	protein localization to chromosome (GO:0034502)	2.87486012
86	microtubule depolymerization (GO:0007019)	2.87478447
87	protein localization to kinetochore (GO:0034501)	2.87177067
88	IMP metabolic process (GO:0046040)	2.87021538
89	terpenoid biosynthetic process (GO:0016114)	2.86023042
90	generation of neurons (GO:0048699)	2.84784825
91	cysteine metabolic process (GO:0006534)	2.81733528
92	histone arginine methylation (GO:0034969)	2.80878759
93	chromosome organization (GO:0051276)	2.79262783
94	ribosome biogenesis (GO:0042254)	2.74696852
95	chromosome condensation (GO:0030261)	2.73686223
96	proline biosynthetic process (GO:0006561)	2.70312169
97	meiotic cell cycle (GO:0051321)	2.70227928
98	regulation of translational elongation (GO:0006448)	2.69519089
99	negative regulation of chromosome segregation (GO:0051985)	2.68491183
100	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.67657680

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.08439170
2	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.14739822
3	FOXM1_23109430_ChIP-Seq_U2OS_Human	3.77998243
4	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.64829141
5	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.57067346
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.23208575
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.19832660
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.15558452
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.10734979
10	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.97397786
11	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.89885838
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.80391508
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.77795393
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.65865602
15	ELK1_19687146_ChIP-ChIP_HELA_Human	2.65396343
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.63716232
17	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.57596431
18	XRN2_22483619_ChIP-Seq_HELA_Human	2.54558422
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.53978092
20	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.46858666
21	GATA1_22025678_ChIP-Seq_K562_Human	2.46040475
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.41140765
23	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.34196056
24	TTF2_22483619_ChIP-Seq_HELA_Human	2.28474537
25	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.26896127
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.26639865
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.26083931
28	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.25994860
29	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.12979615
30	DCP1A_22483619_ChIP-Seq_HELA_Human	2.05750293
31	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.04666897
32	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.04666897
33	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.04666897
34	KDM5A_27292631_Chip-Seq_BREAST_Human	1.83596744
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.83324520
36	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.81241781
37	NCOR1_26117541_ChIP-Seq_K562_Human	1.77733738
38	FOXP3_21729870_ChIP-Seq_TREG_Human	1.77631139
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.76905287
40	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.75826654
41	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.75787730
42	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.75289766
43	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.71200751
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.69998776
45	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.69896023
46	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.64403584
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.60817683
48	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.56687385
49	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.56289005
50	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.51602283
51	ZNF263_19887448_ChIP-Seq_K562_Human	1.49394844
52	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.44496173
53	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.43508582
54	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.42032288
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.36584616
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.36044923
57	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.31408447
58	VDR_22108803_ChIP-Seq_LS180_Human	1.30830676
59	CIITA_25753668_ChIP-Seq_RAJI_Human	1.26906535
60	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.23385132
61	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.20286937
62	GABP_19822575_ChIP-Seq_HepG2_Human	1.17640172
63	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.17280943
64	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.16757657
65	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16204072
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16036027
67	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.14756379
68	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.11708493
69	AR_21909140_ChIP-Seq_LNCAP_Human	1.06017927
70	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04499425
71	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03364209
72	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.02336289
73	GATA1_19941826_ChIP-Seq_K562_Human	1.02298530
74	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.01435800
75	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.98691647
76	FUS_26573619_Chip-Seq_HEK293_Human	0.98549083
77	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.97533312
78	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.96447949
79	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.94461128
80	IGF1R_20145208_ChIP-Seq_DFB_Human	0.94212290
81	ETV1_20927104_ChIP-Seq_GIST48_Human	0.92878942
82	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.92343767
83	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90880256
84	PHF8_20622853_ChIP-Seq_HELA_Human	0.89614332
85	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.89465663
86	RBPJ_21746931_ChIP-Seq_IB4_Human	0.87389009
87	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.85214891
88	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.85085411
89	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.84199064
90	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.81469118
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.79651278
92	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.79493974
93	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.78291965
94	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.75498629
95	GATA2_19941826_ChIP-Seq_K562_Human	0.75030036
96	TFEB_21752829_ChIP-Seq_HELA_Human	0.74441814
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.74276260
98	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.73333930
99	ZNF274_21170338_ChIP-Seq_K562_Hela	0.73302396
100	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.72986665

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	4.05006951
2	MP0008877_abnormal_DNA_methylation	3.52937127
3	MP0008995_early_reproductive_senescence	3.51758472
4	MP0004147_increased_porphyrin_level	3.11962576
5	MP0009379_abnormal_foot_pigmentation	3.10537347
6	MP0004957_abnormal_blastocyst_morpholog	3.08896012
7	MP0010094_abnormal_chromosome_stability	2.98027128
8	MP0003693_abnormal_embryo_hatching	2.82264225
9	MP0003111_abnormal_nucleus_morphology	2.77661682
10	MP0002210_abnormal_sex_determination	2.75901379
11	MP0009697_abnormal_copulation	2.61752884
12	MP0001929_abnormal_gametogenesis	2.33073290
13	MP0008007_abnormal_cellular_replicative	2.25571449
14	MP0010030_abnormal_orbit_morphology	2.23032961
15	MP0003077_abnormal_cell_cycle	2.19336902
16	MP0003136_yellow_coat_color	2.18876953
17	MP0001145_abnormal_male_reproductive	2.12400959
18	MP0008057_abnormal_DNA_replication	1.97930716
19	MP0003698_abnormal_male_reproductive	1.96509358
20	MP0003656_abnormal_erythrocyte_physiolo	1.92887378
21	MP0010307_abnormal_tumor_latency	1.89083300
22	MP0000653_abnormal_sex_gland	1.88138885
23	MP0008789_abnormal_olfactory_epithelium	1.87483160
24	MP0002160_abnormal_reproductive_system	1.86805339
25	MP0005451_abnormal_body_composition	1.82722389
26	MP0000372_irregular_coat_pigmentation	1.80851557
27	MP0003786_premature_aging	1.76619617
28	MP0008932_abnormal_embryonic_tissue	1.76553327
29	MP0002396_abnormal_hematopoietic_system	1.73763802
30	MP0001346_abnormal_lacrimal_gland	1.69743811
31	MP0003567_abnormal_fetal_cardiomyocyte	1.65655760
32	MP0005380_embryogenesis_phenotype	1.61211038
33	MP0001672_abnormal_embryogenesis/_devel	1.61211038
34	MP0003890_abnormal_embryonic-extraembry	1.57985710
35	MP0008004_abnormal_stomach_pH	1.52450214
36	MP0003718_maternal_effect	1.52034869
37	MP0006036_abnormal_mitochondrial_physio	1.51497904
38	MP0001697_abnormal_embryo_size	1.46835135
39	MP0003984_embryonic_growth_retardation	1.44451478
40	MP0006035_abnormal_mitochondrial_morpho	1.37601211
41	MP0000358_abnormal_cell_content/	1.36061181
42	MP0000350_abnormal_cell_proliferation	1.34829365
43	MP0002088_abnormal_embryonic_growth/wei	1.34095081
44	MP0005410_abnormal_fertilization	1.33855085
45	MP0001119_abnormal_female_reproductive	1.32878559
46	MP0000313_abnormal_cell_death	1.32400296
47	MP0002009_preneoplasia	1.29178487
48	MP0002085_abnormal_embryonic_tissue	1.28071790
49	MP0006292_abnormal_olfactory_placode	1.27935487
50	MP0002161_abnormal_fertility/fecundity	1.26131334
51	MP0002080_prenatal_lethality	1.23039487
52	MP0004233_abnormal_muscle_weight	1.22922038
53	MP0003699_abnormal_female_reproductive	1.22850139
54	MP0001730_embryonic_growth_arrest	1.20430744
55	MP0000678_abnormal_parathyroid_gland	1.19797399
56	MP0001286_abnormal_eye_development	1.19498855
57	MP0002084_abnormal_developmental_patter	1.18810337
58	MP0000631_abnormal_neuroendocrine_gland	1.15470132
59	MP0005389_reproductive_system_phenotype	1.13816045
60	MP0001293_anophthalmia	1.12787532
61	MP0003937_abnormal_limbs/digits/tail_de	1.11330628
62	MP0004808_abnormal_hematopoietic_stem	1.10475139
63	MP0002086_abnormal_extraembryonic_tissu	1.10435209
64	MP0001764_abnormal_homeostasis	1.10036700
65	MP0009672_abnormal_birth_weight	1.09009172
66	MP0003942_abnormal_urinary_system	1.04888311
67	MP0003938_abnormal_ear_development	1.04479246
68	MP0003806_abnormal_nucleotide_metabolis	1.02313981
69	MP0005397_hematopoietic_system_phenotyp	1.01223679
70	MP0001545_abnormal_hematopoietic_system	1.01223679
71	MP0003646_muscle_fatigue	0.99452374
72	MP0002102_abnormal_ear_morphology	0.97806155
73	MP0003935_abnormal_craniofacial_develop	0.97060440
74	MP0000428_abnormal_craniofacial_morphol	0.96696955
75	MP0009703_decreased_birth_body	0.95399546
76	MP0010630_abnormal_cardiac_muscle	0.88187458
77	MP0002269_muscular_atrophy	0.86104084
78	MP0003385_abnormal_body_wall	0.86043182
79	MP0002938_white_spotting	0.85812705
80	MP0005503_abnormal_tendon_morphology	0.81539290
81	MP0003959_abnormal_lean_body	0.81055241
82	MP0001529_abnormal_vocalization	0.78337395
83	MP0003755_abnormal_palate_morphology	0.75790015
84	MP0003186_abnormal_redox_activity	0.74474904
85	MP0001661_extended_life_span	0.72925517
86	MP0003941_abnormal_skin_development	0.72878508
87	MP0000613_abnormal_salivary_gland	0.72598510
88	MP0002249_abnormal_larynx_morphology	0.72425152
89	MP0002111_abnormal_tail_morphology	0.72366297
90	MP0006072_abnormal_retinal_apoptosis	0.69767999
91	MP0002233_abnormal_nose_morphology	0.69654868
92	MP0002132_abnormal_respiratory_system	0.69103920
93	MP0003861_abnormal_nervous_system	0.68481208
94	MP0002697_abnormal_eye_size	0.67268063
95	MP0002114_abnormal_axial_skeleton	0.67201934
96	MP0001299_abnormal_eye_distance/	0.65192682
97	MP0000647_abnormal_sebaceous_gland	0.63728826
98	MP0004145_abnormal_muscle_electrophysio	0.62716893
99	MP0002019_abnormal_tumor_incidence	0.62133285
100	MP0003115_abnormal_respiratory_system	0.60822633

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.24724549
2	Abnormality of lateral ventricle (HP:0030047)	4.24858634
3	Truncus arteriosus (HP:0001660)	4.03412498
4	Birth length less than 3rd percentile (HP:0003561)	3.81102628
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.70033459
6	Pallor (HP:0000980)	3.56834761
7	Macrocytic anemia (HP:0001972)	3.55367833
8	Deformed tarsal bones (HP:0008119)	3.53473807
9	Abnormality of reticulocytes (HP:0004312)	3.50909538
10	Calcaneovalgus deformity (HP:0001848)	3.26419425
11	Ankyloglossia (HP:0010296)	3.19409166
12	Hypoparathyroidism (HP:0000829)	3.17421241
13	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.16352292
14	Homocystinuria (HP:0002156)	3.13224706
15	Abnormality of homocysteine metabolism (HP:0010919)	3.13224706
16	Abnormal number of erythroid precursors (HP:0012131)	3.04734416
17	Chromsome breakage (HP:0040012)	3.04505788
18	Abnormality of the calcaneus (HP:0008364)	3.03323694
19	Large hands (HP:0001176)	2.94569337
20	Pheochromocytoma (HP:0002666)	2.91558757
21	Spontaneous abortion (HP:0005268)	2.84026593
22	Duplicated collecting system (HP:0000081)	2.77418469
23	Hyperthyroidism (HP:0000836)	2.75335776
24	Reticulocytosis (HP:0001923)	2.68576112
25	Abnormality of cochlea (HP:0000375)	2.65412936
26	Abnormal hemoglobin (HP:0011902)	2.64354126
27	Abnormality of the renal collecting system (HP:0004742)	2.59571635
28	Tinnitus (HP:0000360)	2.57858104
29	Cholecystitis (HP:0001082)	2.51596632
30	Abnormal gallbladder physiology (HP:0012438)	2.51596632
31	Polycythemia (HP:0001901)	2.51216353
32	Short middle phalanx of the 5th finger (HP:0004220)	2.47545057
33	Acute myeloid leukemia (HP:0004808)	2.47007684
34	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.42862330
35	11 pairs of ribs (HP:0000878)	2.40567840
36	Partial agenesis of the corpus callosum (HP:0001338)	2.40295130
37	Neuroendocrine neoplasm (HP:0100634)	2.34181972
38	Small intestinal stenosis (HP:0012848)	2.33591902
39	Duodenal stenosis (HP:0100867)	2.33591902
40	Palpitations (HP:0001962)	2.32309026
41	Increased nuchal translucency (HP:0010880)	2.32170324
42	Bowel incontinence (HP:0002607)	2.30899002
43	Abnormality of oral frenula (HP:0000190)	2.30298916
44	Deep philtrum (HP:0002002)	2.30163908
45	Cerebellar dysplasia (HP:0007033)	2.28783761
46	Abnormality of the heme biosynthetic pathway (HP:0010472)	2.19389829
47	Abnormal large intestine physiology (HP:0012700)	2.18500453
48	Orthostatic hypotension (HP:0001278)	2.15247918
49	Abnormality of DNA repair (HP:0003254)	2.14954955
50	Azoospermia (HP:0000027)	2.13822088
51	Sandal gap (HP:0001852)	2.13647587
52	Myelodysplasia (HP:0002863)	2.12505929
53	Atrioventricular block (HP:0001678)	2.10400763
54	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.08674628
55	Abnormal hair whorl (HP:0010721)	2.08434366
56	Abnormality of the fingertips (HP:0001211)	2.08071620
57	Abnormality of the preputium (HP:0100587)	2.07299051
58	Ependymoma (HP:0002888)	2.05892962
59	Angiofibromas (HP:0010615)	2.04256068
60	Adenoma sebaceum (HP:0009720)	2.04256068
61	Missing ribs (HP:0000921)	2.04003209
62	Meningioma (HP:0002858)	2.03543438
63	Poikilocytosis (HP:0004447)	2.02431842
64	Cafe-au-lait spot (HP:0000957)	2.01722935
65	Abnormality of the tricuspid valve (HP:0001702)	2.01507798
66	Selective tooth agenesis (HP:0001592)	2.00500287
67	Abnormal number of incisors (HP:0011064)	1.98586424
68	Neoplasm of the peripheral nervous system (HP:0100007)	1.97925494
69	Triphalangeal thumb (HP:0001199)	1.95847524
70	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.95003547
71	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.95003547
72	Lip pit (HP:0100267)	1.94228099
73	Meckel diverticulum (HP:0002245)	1.93737647
74	Abnormality of chromosome stability (HP:0003220)	1.93241189
75	Hamartoma of the eye (HP:0010568)	1.90276025
76	Delayed myelination (HP:0012448)	1.89245739
77	Ectopic kidney (HP:0000086)	1.88573203
78	Ileus (HP:0002595)	1.87223476
79	Central scotoma (HP:0000603)	1.86106063
80	Duplication of thumb phalanx (HP:0009942)	1.84938057
81	Abnormally folded helix (HP:0008544)	1.84549465
82	Seborrheic dermatitis (HP:0001051)	1.84222971
83	Hypoplastic iliac wings (HP:0002866)	1.83778085
84	Abnormality of the ileum (HP:0001549)	1.83403631
85	Broad distal phalanx of finger (HP:0009836)	1.80145583
86	Abnormality of the duodenum (HP:0002246)	1.79776787
87	Hypoplasia of the radius (HP:0002984)	1.78504306
88	Cortical dysplasia (HP:0002539)	1.78055361
89	Increased serum pyruvate (HP:0003542)	1.77414394
90	Abnormality of the labia minora (HP:0012880)	1.76697356
91	Morphological abnormality of the inner ear (HP:0011390)	1.76586936
92	Abnormality of the pons (HP:0007361)	1.76570865
93	Abnormal spermatogenesis (HP:0008669)	1.76021137
94	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.76001755
95	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.74400134
96	Abnormality of the anterior horn cell (HP:0006802)	1.73314895
97	Degeneration of anterior horn cells (HP:0002398)	1.73314895
98	Volvulus (HP:0002580)	1.72327852
99	Neoplasm of the colon (HP:0100273)	1.72311707
100	Abnormality of the carotid arteries (HP:0005344)	1.70674384

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BMPR2	3.48467434
2	TTK	3.40210358
3	EIF2AK1	3.38511944
4	NEK2	2.76315974
5	SCYL2	2.67452452
6	KSR2	2.54555274
7	NTRK1	2.48492572
8	PNCK	2.46421031
9	MAP3K2	2.19111434
10	BRSK2	2.01637230
11	YES1	2.01298665
12	CLK1	1.94090090
13	ZAK	1.93652446
14	RIPK4	1.91059530
15	PBK	1.87000696
16	NEK1	1.82794431
17	PLK4	1.77191390
18	CDK3	1.76505324
19	BRD4	1.73460303
20	TRPM7	1.73401448
21	WEE1	1.72516036
22	BMX	1.69713552
23	MKNK1	1.69298726
24	EEF2K	1.61424391
25	KSR1	1.60898865
26	EIF2AK3	1.55611797
27	WNK1	1.53104907
28	RAF1	1.51845478
29	CDK19	1.47562150
30	LATS1	1.47291217
31	CAMK1G	1.46490493
32	MET	1.46245734
33	CDC7	1.44374883
34	BUB1	1.41448783
35	MATK	1.32713713
36	NTRK3	1.31164337
37	CDK12	1.27033028
38	CCNB1	1.25918600
39	MKNK2	1.23844234
40	PLK1	1.23612874
41	RPS6KB2	1.20136004
42	IRAK4	1.19559859
43	STK3	1.17636837
44	CHEK1	1.16372809
45	ATR	1.11469126
46	CDK8	1.11449300
47	CHEK2	1.11304859
48	IRAK3	1.01254213
49	NME1	0.99631587
50	ILK	0.97784845
51	RPS6KA4	0.94117366
52	PLK3	0.90615450
53	PIK3CG	0.89776298
54	PDK2	0.85007736
55	DYRK3	0.81863687
56	SRPK1	0.81683972
57	MAP3K10	0.81061314
58	RET	0.77591991
59	AURKB	0.76847308
60	MAP3K8	0.76740289
61	OXSR1	0.75240552
62	CDK1	0.74243666
63	ERBB3	0.73720353
64	TSSK6	0.73406035
65	PAK1	0.71984345
66	PAK2	0.71003953
67	STK4	0.70362238
68	BRSK1	0.69528370
69	ALK	0.69349748
70	CAMK1D	0.68493663
71	PIM1	0.67552145
72	MAP2K6	0.66982406
73	CDK2	0.66542258
74	FLT3	0.65624012
75	PRKCI	0.62740874
76	NME2	0.62173264
77	ATM	0.61627203
78	DYRK2	0.61607661
79	PASK	0.60069763
80	JAK3	0.58507624
81	MAP2K1	0.58094199
82	MAPKAPK5	0.57639078
83	CSNK2A2	0.51705721
84	VRK1	0.50230916
85	WNK4	0.48273361
86	CSNK1E	0.45623229
87	RPS6KB1	0.45337000
88	PAK6	0.41754580
89	FGFR1	0.41521178
90	CDK7	0.41249978
91	JAK2	0.41056986
92	CDK4	0.40039952
93	STK16	0.39453395
94	TYRO3	0.39084596
95	BRAF	0.38515178
96	GRK6	0.38374077
97	MST1R	0.36853772
98	MTOR	0.36426401
99	RPS6KA5	0.36314612
100	NUAK1	0.35840810

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.42320941
2	Homologous recombination_Homo sapiens_hsa03440	4.18649980
3	Mismatch repair_Homo sapiens_hsa03430	3.48433479
4	Selenocompound metabolism_Homo sapiens_hsa00450	3.47047250
5	One carbon pool by folate_Homo sapiens_hsa00670	3.28382405
6	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	3.22493369
7	DNA replication_Homo sapiens_hsa03030	3.03534249
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.93875315
9	RNA transport_Homo sapiens_hsa03013	2.84854817
10	Cell cycle_Homo sapiens_hsa04110	2.55212214
11	Parkinsons disease_Homo sapiens_hsa05012	2.42998461
12	Nucleotide excision repair_Homo sapiens_hsa03420	2.36116240
13	Oxidative phosphorylation_Homo sapiens_hsa00190	2.33233055
14	Fanconi anemia pathway_Homo sapiens_hsa03460	2.20718246
15	Huntingtons disease_Homo sapiens_hsa05016	2.07625500
16	RNA degradation_Homo sapiens_hsa03018	2.06264536
17	Spliceosome_Homo sapiens_hsa03040	2.06098463
18	Basal transcription factors_Homo sapiens_hsa03022	1.98671320
19	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.88377725
20	Butanoate metabolism_Homo sapiens_hsa00650	1.77336886
21	Proteasome_Homo sapiens_hsa03050	1.72071437
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.70346522
23	Thyroid cancer_Homo sapiens_hsa05216	1.44822943
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.43544137
25	Alzheimers disease_Homo sapiens_hsa05010	1.35386611
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.28809959
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.20803623
28	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.19356906
29	Olfactory transduction_Homo sapiens_hsa04740	1.12875985
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.12027038
31	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.09359102
32	RNA polymerase_Homo sapiens_hsa03020	1.09133263
33	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.08048375
34	Oocyte meiosis_Homo sapiens_hsa04114	1.05444802
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.03312549
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02499423
37	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.01939039
38	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.99821006
39	Propanoate metabolism_Homo sapiens_hsa00640	0.99236331
40	Purine metabolism_Homo sapiens_hsa00230	0.92894064
41	Pyrimidine metabolism_Homo sapiens_hsa00240	0.92887520
42	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92750860
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.89562096
44	Lysine degradation_Homo sapiens_hsa00310	0.84071670
45	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.77550211
46	Renal cell carcinoma_Homo sapiens_hsa05211	0.71417803
47	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.69870426
48	Steroid biosynthesis_Homo sapiens_hsa00100	0.60405757
49	Protein export_Homo sapiens_hsa03060	0.59796775
50	p53 signaling pathway_Homo sapiens_hsa04115	0.54225207
51	Ether lipid metabolism_Homo sapiens_hsa00565	0.51963312
52	Carbon metabolism_Homo sapiens_hsa01200	0.51898525
53	Pancreatic cancer_Homo sapiens_hsa05212	0.51562687
54	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.50316079
55	Base excision repair_Homo sapiens_hsa03410	0.49446090
56	mTOR signaling pathway_Homo sapiens_hsa04150	0.49384137
57	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.47754698
58	Non-small cell lung cancer_Homo sapiens_hsa05223	0.47557903
59	Metabolic pathways_Homo sapiens_hsa01100	0.45854917
60	ErbB signaling pathway_Homo sapiens_hsa04012	0.44228473
61	Acute myeloid leukemia_Homo sapiens_hsa05221	0.43439007
62	Nitrogen metabolism_Homo sapiens_hsa00910	0.40893826
63	MicroRNAs in cancer_Homo sapiens_hsa05206	0.39211104
64	Sulfur metabolism_Homo sapiens_hsa00920	0.39154304
65	Small cell lung cancer_Homo sapiens_hsa05222	0.36856799
66	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.36197538
67	Sulfur relay system_Homo sapiens_hsa04122	0.31602657
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.31343980
69	Viral carcinogenesis_Homo sapiens_hsa05203	0.31050718
70	Retinol metabolism_Homo sapiens_hsa00830	0.28586337
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.28509563
72	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.28216441
73	Bladder cancer_Homo sapiens_hsa05219	0.27056033
74	Tryptophan metabolism_Homo sapiens_hsa00380	0.25690550
75	Regulation of autophagy_Homo sapiens_hsa04140	0.25491535
76	Fatty acid metabolism_Homo sapiens_hsa01212	0.24116898
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22537487
78	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.22097566
79	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.22012081
80	Melanoma_Homo sapiens_hsa05218	0.21860931
81	Alcoholism_Homo sapiens_hsa05034	0.18914073
82	Shigellosis_Homo sapiens_hsa05131	0.16764134
83	Pathways in cancer_Homo sapiens_hsa05200	0.16732789
84	ECM-receptor interaction_Homo sapiens_hsa04512	0.16485428
85	Apoptosis_Homo sapiens_hsa04210	0.16299240
86	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.16012492
87	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.15368078
88	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.13584347
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.12614790
90	Colorectal cancer_Homo sapiens_hsa05210	0.11898935
91	Taste transduction_Homo sapiens_hsa04742	0.11032461
92	Linoleic acid metabolism_Homo sapiens_hsa00591	0.10680841
93	Nicotine addiction_Homo sapiens_hsa05033	0.09795724
94	Insulin signaling pathway_Homo sapiens_hsa04910	0.09419120
95	Fatty acid degradation_Homo sapiens_hsa00071	0.09035258
96	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.07894643
97	Glutathione metabolism_Homo sapiens_hsa00480	0.06125915
98	VEGF signaling pathway_Homo sapiens_hsa04370	0.06119498
99	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.05864650
100	Pentose phosphate pathway_Homo sapiens_hsa00030	0.04755709

NF1P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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