NFAM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.97292894
2positive regulation by symbiont of host defense response (GO:0052509)5.89231351
3modulation by symbiont of host defense response (GO:0052031)5.89231351
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.89231351
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.89231351
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.89231351
7modulation by symbiont of host immune response (GO:0052553)5.89231351
8cellular extravasation (GO:0045123)5.45587537
9regulation of interferon-beta biosynthetic process (GO:0045357)5.35813118
10respiratory burst (GO:0045730)5.30928309
11detection of bacterium (GO:0016045)5.26556590
12response to peptidoglycan (GO:0032494)5.16554541
13neutrophil mediated immunity (GO:0002446)5.03428582
14leukocyte aggregation (GO:0070486)4.95182810
15positive regulation of mast cell activation (GO:0033005)4.89059596
16macrophage activation involved in immune response (GO:0002281)4.80872260
17production of molecular mediator involved in inflammatory response (GO:0002532)4.70714122
18detection of external biotic stimulus (GO:0098581)4.68148137
19immunoglobulin mediated immune response (GO:0016064)4.60968330
20detection of molecule of bacterial origin (GO:0032490)4.52669229
21regulation of mast cell degranulation (GO:0043304)4.52276525
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48222849
23neutrophil activation (GO:0042119)4.46635267
24regulation of mast cell activation (GO:0033003)4.39054546
25* regulation of B cell receptor signaling pathway (GO:0050855)4.38873658
26response to host immune response (GO:0052572)4.37293799
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.37293799
28leukocyte migration involved in inflammatory response (GO:0002523)4.37228188
29negative regulation of lymphocyte mediated immunity (GO:0002707)4.36827950
30positive regulation of mast cell degranulation (GO:0043306)4.32332209
31positive regulation of mast cell activation involved in immune response (GO:0033008)4.32332209
32regulation of mast cell activation involved in immune response (GO:0033006)4.28076741
33positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.25415025
34granulocyte activation (GO:0036230)4.22421179
35positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.15361746
36regulation of gamma-delta T cell activation (GO:0046643)4.13355662
37response to fungus (GO:0009620)4.11890899
38detection of biotic stimulus (GO:0009595)4.11855122
39response to host (GO:0075136)4.06583155
40response to host defenses (GO:0052200)4.06583155
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.06583155
42regulation of myeloid leukocyte mediated immunity (GO:0002886)4.01343067
43response to interleukin-15 (GO:0070672)4.00275900
44defense response to fungus (GO:0050832)3.95989634
45regulation of leukocyte degranulation (GO:0043300)3.95901846
46negative regulation of phagocytosis (GO:0050765)3.91920517
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.91798700
48negative regulation of cell killing (GO:0031342)3.91798700
49negative regulation of granulocyte differentiation (GO:0030853)3.90867647
50Arp2/3 complex-mediated actin nucleation (GO:0034314)3.89943610
51negative regulation of leukocyte mediated immunity (GO:0002704)3.87337903
52microglial cell activation (GO:0001774)3.86318930
53myeloid cell activation involved in immune response (GO:0002275)3.86208457
54positive regulation of interferon-alpha production (GO:0032727)3.81699241
55myeloid leukocyte mediated immunity (GO:0002444)3.72662393
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.71278146
57positive regulation of B cell differentiation (GO:0045579)3.69947070
58negative regulation of interleukin-12 production (GO:0032695)3.68620945
59cellular response to interleukin-15 (GO:0071350)3.67481575
60macrophage differentiation (GO:0030225)3.65459362
61negative regulation of T cell mediated immunity (GO:0002710)3.64302178
62neutrophil chemotaxis (GO:0030593)3.62629638
63positive regulation of antigen processing and presentation (GO:0002579)3.60237496
64regulation of interferon-alpha production (GO:0032647)3.57457601
65positive regulation of gamma-delta T cell activation (GO:0046645)3.54196329
66killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.52711624
67disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.52711624
68neutrophil migration (GO:1990266)3.52067652
69regulation of gamma-delta T cell differentiation (GO:0045586)3.50469403
70antigen processing and presentation via MHC class Ib (GO:0002475)3.47028929
71positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.46127164
72response to muramyl dipeptide (GO:0032495)3.44349309
73regulation of T cell tolerance induction (GO:0002664)3.44348980
74cellular response to type I interferon (GO:0071357)3.44149624
75type I interferon signaling pathway (GO:0060337)3.44149624
76response to type I interferon (GO:0034340)3.41568069
77B cell mediated immunity (GO:0019724)3.39924189
78positive regulation of leukocyte degranulation (GO:0043302)3.39392611
79regulation of tolerance induction (GO:0002643)3.38148312
80negative regulation of mast cell activation (GO:0033004)3.38145310
81macrophage activation (GO:0042116)3.36102370
82leukotriene metabolic process (GO:0006691)3.36004628
83leukocyte mediated cytotoxicity (GO:0001909)3.34336371
84regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34093189
85antigen processing and presentation of endogenous antigen (GO:0019883)3.32542415
86positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.29791254
87negative regulation of interleukin-6 production (GO:0032715)3.26946131
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.26590836
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26590836
90leukocyte cell-cell adhesion (GO:0007159)3.23429425
91regulation of regulated secretory pathway (GO:1903305)3.22176594
92positive regulation of lamellipodium assembly (GO:0010592)3.20464842
93negative regulation of erythrocyte differentiation (GO:0045647)3.20343499
94cellular response to zinc ion (GO:0071294)3.19708518
95reactive oxygen species biosynthetic process (GO:1903409)3.19012920
96* positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.18615660
97interferon-gamma-mediated signaling pathway (GO:0060333)3.16915627
98regulation of T-helper 2 cell differentiation (GO:0045628)3.16458225
99negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.16371737
100lipoxygenase pathway (GO:0019372)3.15782415
101detection of other organism (GO:0098543)3.13264488
102pinocytosis (GO:0006907)3.13202593
103regulation of interleukin-8 biosynthetic process (GO:0045414)3.11047856
104regulation of integrin activation (GO:0033623)3.09694980
105negative regulation of cytokine production involved in immune response (GO:0002719)3.06776814
106superoxide anion generation (GO:0042554)3.06188346
107regulation of T cell mediated cytotoxicity (GO:0001914)3.06105704
108granulocyte chemotaxis (GO:0071621)3.05596917
109positive regulation of interferon-beta production (GO:0032728)3.05425888
110hydrogen peroxide biosynthetic process (GO:0050665)3.05389748
111dendritic cell migration (GO:0036336)3.01805788
112positive regulation of T cell mediated cytotoxicity (GO:0001916)3.00176681
113positive regulation of cellular amide metabolic process (GO:0034250)2.99980170
114granulocyte migration (GO:0097530)2.98759029
115negative regulation of innate immune response (GO:0045824)2.98417909
116regulation of antigen processing and presentation (GO:0002577)2.98342089
117dendritic cell chemotaxis (GO:0002407)2.97632134
118regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96929338
119lipopolysaccharide-mediated signaling pathway (GO:0031663)2.95846986
120regulation of natural killer cell mediated immunity (GO:0002715)2.95593051
121regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.95593051
122negative regulation of type 2 immune response (GO:0002829)2.95577319
123actin nucleation (GO:0045010)2.95307855
124regulation of phagocytosis (GO:0050764)2.93970423
125negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.93468377
126negative regulation of T-helper cell differentiation (GO:0045623)2.93468377
127leukocyte degranulation (GO:0043299)2.91818476
128negative regulation of alpha-beta T cell activation (GO:0046636)2.91433902
129myeloid leukocyte activation (GO:0002274)2.90528633
130positive regulation of lamellipodium organization (GO:1902745)2.89011473
131activated T cell proliferation (GO:0050798)2.88777983
132* regulation of B cell differentiation (GO:0045577)2.85019158
133* B cell receptor signaling pathway (GO:0050853)2.84652574
134mannose metabolic process (GO:0006013)2.83993763
135G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77481470
136leukotriene biosynthetic process (GO:0019370)2.75884610
137germinal center formation (GO:0002467)2.75783857
138positive regulation of toll-like receptor signaling pathway (GO:0034123)2.73341117
139defense response to protozoan (GO:0042832)2.72887013
140regulation of dendritic cell antigen processing and presentation (GO:0002604)2.72805588

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse5.46993635
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.13539743
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.22831769
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.91429742
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.83127852
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.79374961
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.69263697
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.37537352
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.13802217
10VDR_21846776_ChIP-Seq_THP-1_Human3.04590182
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.02652797
12E2F7_22180533_ChIP-Seq_HELA_Human2.91324421
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.87868389
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83394434
15BRD4_27068464_Chip-Seq_AML-cells_Mouse2.79907758
16* SPI1_23547873_ChIP-Seq_NB4_Human2.66241645
17SCL_19346495_ChIP-Seq_HPC-7_Human2.62689301
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60300837
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.54094426
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.49274362
21VDR_24763502_ChIP-Seq_THP-1_Human2.42756323
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.39622717
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23140172
24RUNX1_22412390_ChIP-Seq_EML_Mouse2.19633747
25* SPI1_23127762_ChIP-Seq_K562_Human2.10010241
26MYC_22102868_ChIP-Seq_BL_Human2.08892991
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05769489
28NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03096157
29MAF_26560356_Chip-Seq_TH1_Human1.98490378
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.93818024
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92261274
32MYB_26560356_Chip-Seq_TH2_Human1.92186200
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87306344
34MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.86365598
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77566263
36PU_27001747_Chip-Seq_BMDM_Mouse1.75597875
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74769558
38* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74748859
39UTX_26944678_Chip-Seq_JUKART_Human1.72200251
40* TCF7_22412390_ChIP-Seq_EML_Mouse1.70365077
41MYB_26560356_Chip-Seq_TH1_Human1.68981217
42PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66512175
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.62246040
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61937467
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.61870032
46SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60742789
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58670297
48FOXM1_23109430_ChIP-Seq_U2OS_Human1.58116481
49RUNX_20019798_ChIP-Seq_JUKART_Human1.56595958
50* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54808975
51SMAD_19615063_ChIP-ChIP_OVARY_Human1.53212656
52* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.51783192
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47985981
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45690920
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.42385916
56CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41997500
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36213496
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35981488
59ELK3_25401928_ChIP-Seq_HUVEC_Human1.33488463
60TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32093101
61LXR_22292898_ChIP-Seq_THP-1_Human1.31291914
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30516855
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29758117
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28939014
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.26085944
66* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25036608
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24758125
68KDM2B_26808549_Chip-Seq_DND41_Human1.24068247
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23840215
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.23452252
71GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22607037
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22351741
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20588263
74TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18152045
75MAF_26560356_Chip-Seq_TH2_Human1.17896599
76VDR_24787735_ChIP-Seq_THP-1_Human1.17357174
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17212414
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16970528
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.16627254
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.16206107
81VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15760857
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13848248
83GATA3_27048872_Chip-Seq_THYMUS_Human1.11989023
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11679635
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08917710
86SPI1_20517297_ChIP-Seq_HL60_Human1.06412923
87TFEB_21752829_ChIP-Seq_HELA_Human1.03403764
88GATA3_26560356_Chip-Seq_TH2_Human0.97965898
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96698765
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94175894
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92485593
92ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92141532
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91441726
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89690629
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89385657
96BCL6_27268052_Chip-Seq_Bcells_Human0.88168523
97GATA1_19941826_ChIP-Seq_K562_Human0.87957777
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84433120
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84004768
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.83370381
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83100399
102* GATA2_19941826_ChIP-Seq_K562_Human0.82565073
103SA1_27219007_Chip-Seq_ERYTHROID_Human0.81778483
104BCOR_27268052_Chip-Seq_Bcells_Human0.81701286
105NOTCH1_21737748_ChIP-Seq_TLL_Human0.79209090
106ELF1_17652178_ChIP-ChIP_JURKAT_Human0.78448711
107NCOR1_26117541_ChIP-Seq_K562_Human0.78219769
108CTCF_27219007_Chip-Seq_ERYTHROID_Human0.74452595
109CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73690410
110GATA1_22025678_ChIP-Seq_K562_Human0.69767828
111P300_27268052_Chip-Seq_Bcells_Human0.69766774
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68924903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.03366609
2MP0003303_peritoneal_inflammation3.93935388
3MP0001835_abnormal_antigen_presentation3.78510762
4MP0005058_abnormal_lysosome_morphology3.41857248
5MP0002419_abnormal_innate_immunity3.25525331
6MP0009278_abnormal_bone_marrow3.14403465
7MP0009785_altered_susceptibility_to2.85825129
8MP0005025_abnormal_response_to2.68652790
9MP0005000_abnormal_immune_tolerance2.65404950
10MP0002148_abnormal_hypersensitivity_rea2.65099565
11MP0003172_abnormal_lysosome_physiology2.61827949
12MP0005464_abnormal_platelet_physiology2.56242298
13MP0002452_abnormal_antigen_presenting2.52222554
14MP0006082_CNS_inflammation2.45944891
15MP0000685_abnormal_immune_system2.45025119
16MP0001800_abnormal_humoral_immune2.44332274
17MP0001790_abnormal_immune_system2.35504486
18MP0005387_immune_system_phenotype2.35504486
19MP0003191_abnormal_cellular_cholesterol2.34943537
20MP0002723_abnormal_immune_serum2.24938347
21MP0001819_abnormal_immune_cell2.24491733
22MP0002420_abnormal_adaptive_immunity2.24327734
23MP0002405_respiratory_system_inflammati2.19662272
24MP0001853_heart_inflammation2.19592292
25MP0001545_abnormal_hematopoietic_system2.16681525
26MP0005397_hematopoietic_system_phenotyp2.16681525
27MP0003724_increased_susceptibility_to2.16271281
28MP0001533_abnormal_skeleton_physiology2.02527429
29MP0005671_abnormal_response_to1.99942717
30MP0002396_abnormal_hematopoietic_system1.98243080
31MP0003183_abnormal_peptide_metabolism1.96153852
32MP0000343_altered_response_to1.93584982
33MP0003075_altered_response_to1.88214477
34MP0000465_gastrointestinal_hemorrhage1.85843793
35MP0001845_abnormal_inflammatory_respons1.82008037
36MP0004510_myositis1.81277235
37MP0003300_gastrointestinal_ulcer1.75037405
38MP0002398_abnormal_bone_marrow1.73996515
39MP0000716_abnormal_immune_system1.73739955
40MP0005174_abnormal_tail_pigmentation1.70805326
41MP0000689_abnormal_spleen_morphology1.67777548
42MP0009840_abnormal_foam_cell1.61404727
43MP0009333_abnormal_splenocyte_physiolog1.52695012
44MP0010155_abnormal_intestine_physiology1.48874292
45MP0005451_abnormal_body_composition1.48277891
46MP0002166_altered_tumor_susceptibility1.48201649
47MP0002429_abnormal_blood_cell1.48114008
48MP0002722_abnormal_immune_system1.46024549
49MP0004808_abnormal_hematopoietic_stem1.44924152
50MP0008469_abnormal_protein_level1.43960611
51MP0000858_altered_metastatic_potential1.42274969
52MP0004947_skin_inflammation1.39795062
53MP0003448_altered_tumor_morphology1.39477405
54MP0001851_eye_inflammation1.38397684
55MP0005167_abnormal_blood-brain_barrier1.37538379
56MP0004381_abnormal_hair_follicle1.35670129
57MP0003828_pulmonary_edema1.34224514
58MP0009764_decreased_sensitivity_to1.32484512
59MP0001873_stomach_inflammation1.28481617
60MP0000569_abnormal_digit_pigmentation1.26879944
61MP0002933_joint_inflammation1.26523744
62MP0000490_abnormal_crypts_of1.22254036
63MP0002006_tumorigenesis1.18440526
64MP0010307_abnormal_tumor_latency1.16171212
65MP0005310_abnormal_salivary_gland1.15791509
66MP0003656_abnormal_erythrocyte_physiolo1.14956959
67MP0003566_abnormal_cell_adhesion1.12267671
68MP0005076_abnormal_cell_differentiation1.12043775
69MP0005166_decreased_susceptibility_to1.09938172
70MP0000015_abnormal_ear_pigmentation1.07010868
71MP0003690_abnormal_glial_cell1.06764605
72MP0004883_abnormal_blood_vessel1.02004046
73MP0008057_abnormal_DNA_replication1.00086944
74MP0005390_skeleton_phenotype0.97880129
75MP0000371_diluted_coat_color0.92654175
76MP0003806_abnormal_nucleotide_metabolis0.91650041
77MP0002998_abnormal_bone_remodeling0.90893395
78MP0008004_abnormal_stomach_pH0.90576374
79MP0005164_abnormal_response_to0.89986584
80MP0000604_amyloidosis0.87356285
81MP0003763_abnormal_thymus_physiology0.86410175
82MP0005023_abnormal_wound_healing0.86279187
83MP0005075_abnormal_melanosome_morpholog0.84233472
84MP0001986_abnormal_taste_sensitivity0.83271286
85MP0000703_abnormal_thymus_morphology0.83213026
86MP0000249_abnormal_blood_vessel0.82545212
87MP0003279_aneurysm0.82299362
88MP0009763_increased_sensitivity_to0.81351884
89MP0003453_abnormal_keratinocyte_physiol0.78907587
90MP0003045_fibrosis0.75175991
91MP0002132_abnormal_respiratory_system0.72924351
92MP0002019_abnormal_tumor_incidence0.72446224
93MP0003866_abnormal_defecation0.69191651
94MP0001663_abnormal_digestive_system0.69092031
95MP0010352_gastrointestinal_tract_polyps0.67505924
96MP0002277_abnormal_respiratory_mucosa0.66448929
97MP0009765_abnormal_xenobiotic_induced0.66155237
98MP0003878_abnormal_ear_physiology0.66080486
99MP0005377_hearing/vestibular/ear_phenot0.66080486
100MP0003638_abnormal_response/metabolism_0.63996655
101MP0002138_abnormal_hepatobiliary_system0.63021743
102MP0008874_decreased_physiological_sensi0.62768339
103MP0003795_abnormal_bone_structure0.61653555
104MP0004130_abnormal_muscle_cell0.61524692
105MP0004858_abnormal_nervous_system0.59968340
106MP0005319_abnormal_enzyme/_coenzyme0.58496985
107MP0005083_abnormal_biliary_tract0.57633168
108MP0008873_increased_physiological_sensi0.56964553
109MP0003221_abnormal_cardiomyocyte_apopto0.55968543
110MP0002928_abnormal_bile_duct0.55816961
111MP0000609_abnormal_liver_physiology0.55691314
112MP0008260_abnormal_autophagy0.54360791
113MP0002095_abnormal_skin_pigmentation0.54324341
114MP0002133_abnormal_respiratory_system0.53525178
115MP0005388_respiratory_system_phenotype0.53525178
116MP0002332_abnormal_exercise_endurance0.53350244
117MP0001915_intracranial_hemorrhage0.53003999
118MP0005248_abnormal_Harderian_gland0.52423230
119MP0000598_abnormal_liver_morphology0.52246540
120MP0001958_emphysema0.52009009
121MP0000767_abnormal_smooth_muscle0.50527817

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.82486627
2Recurrent bacterial skin infections (HP:0005406)6.89163754
3Eczematoid dermatitis (HP:0000976)6.66651492
4Recurrent gram-negative bacterial infections (HP:0005420)6.19455092
5Systemic lupus erythematosus (HP:0002725)5.14334746
6Abnormality of macrophages (HP:0004311)4.79053643
7Vacuolated lymphocytes (HP:0001922)4.58922795
8Increased cerebral lipofuscin (HP:0011813)4.51409597
9Chronic obstructive pulmonary disease (HP:0006510)4.43429505
10Obstructive lung disease (HP:0006536)4.43429505
11Dysostosis multiplex (HP:0000943)4.27697647
12Mediastinal lymphadenopathy (HP:0100721)4.26531047
13Gastrointestinal infarctions (HP:0005244)4.23889295
14Myositis (HP:0100614)4.20119972
15Hypochromic microcytic anemia (HP:0004840)4.16062937
16Increased neuronal autofluorescent lipopigment (HP:0002074)4.12089179
17Recurrent skin infections (HP:0001581)4.10353585
18Recurrent fungal infections (HP:0002841)3.88765853
19Pustule (HP:0200039)3.88312558
20Gingivitis (HP:0000230)3.86503008
21Encephalitis (HP:0002383)3.77293272
22Glomerulonephritis (HP:0000099)3.64389904
23Keratoconjunctivitis (HP:0001096)3.61755105
24Mucopolysacchariduria (HP:0008155)3.57822986
25Urinary glycosaminoglycan excretion (HP:0003541)3.57822986
26Elevated erythrocyte sedimentation rate (HP:0003565)3.53689141
27Spontaneous hematomas (HP:0007420)3.51478701
28Hypochromic anemia (HP:0001931)3.48861206
29Cellulitis (HP:0100658)3.44646968
30Abnormality of liposaccharide metabolism (HP:0010968)3.36667083
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.36667083
32Abnormality of glycolipid metabolism (HP:0010969)3.36667083
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.34232096
34Abnormality of polysaccharide metabolism (HP:0011012)3.34232096
35Abnormality of glycosaminoglycan metabolism (HP:0004371)3.34232096
36Episodic fever (HP:0001954)3.28956596
37IgM deficiency (HP:0002850)3.26800075
38Orchitis (HP:0100796)3.23703051
39Stomatitis (HP:0010280)3.14992697
40Urticaria (HP:0001025)3.09346729
41Meningitis (HP:0001287)3.09094379
42Periodontitis (HP:0000704)3.00052685
43Amyloidosis (HP:0011034)3.00023087
44Inflammation of the large intestine (HP:0002037)2.91881202
45Peritonitis (HP:0002586)2.91164912
46Colitis (HP:0002583)2.90420747
47Disinhibition (HP:0000734)2.89902504
48Recurrent viral infections (HP:0004429)2.88118892
49Agnosia (HP:0010524)2.87759316
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.86218309
51Hematochezia (HP:0002573)2.83871736
52Anorexia (HP:0002039)2.82190761
53Gastrointestinal inflammation (HP:0004386)2.80258423
54T lymphocytopenia (HP:0005403)2.77582061
55Pulmonary embolism (HP:0002204)2.72266602
56Prolonged bleeding time (HP:0003010)2.71232577
57Axonal loss (HP:0003447)2.70904115
58Abnormality of T cell number (HP:0011839)2.67822319
59Loss of speech (HP:0002371)2.66407062
60Petechiae (HP:0000967)2.65561587
61Interstitial pulmonary disease (HP:0006530)2.62876374
62Autoimmune thrombocytopenia (HP:0001973)2.62654003
63Microcytic anemia (HP:0001935)2.57022907
64Abnormality of complement system (HP:0005339)2.55275679
65Hepatosplenomegaly (HP:0001433)2.54097606
66Epistaxis (HP:0000421)2.52356601
67Vasculitis (HP:0002633)2.52054447
68Retrobulbar optic neuritis (HP:0100654)2.49381645
69Optic neuritis (HP:0100653)2.49381645
70Increased IgM level (HP:0003496)2.48768197
71Abnormality of T cells (HP:0002843)2.45800710
72Recurrent cutaneous fungal infections (HP:0011370)2.45502244
73Chronic mucocutaneous candidiasis (HP:0002728)2.45502244
74Panhypogammaglobulinemia (HP:0003139)2.42856182
75Osteomyelitis (HP:0002754)2.41595452
76Thoracic kyphosis (HP:0002942)2.40171342
77Abnormality of the pleura (HP:0002103)2.39205894
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.37405718
79Granulocytopenia (HP:0001913)2.35771660
80Complement deficiency (HP:0004431)2.35350312
81Nephritis (HP:0000123)2.34717972
82Chronic otitis media (HP:0000389)2.34529387
83Gangrene (HP:0100758)2.33964917
84Leukocytosis (HP:0001974)2.30274028
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29828956
86Abnormal platelet function (HP:0011869)2.27666723
87Impaired platelet aggregation (HP:0003540)2.27666723
88Purpura (HP:0000979)2.26981545
89Thrombocytosis (HP:0001894)2.24859760
90Prostate neoplasm (HP:0100787)2.24181010
91Lymphopenia (HP:0001888)2.22555760
92Abnormality of the peritoneum (HP:0002585)2.22134564
93Spondylolisthesis (HP:0003302)2.19868290
94Increased serum ferritin (HP:0003281)2.19819379
95Gingival bleeding (HP:0000225)2.19503622
96Recurrent pneumonia (HP:0006532)2.18141238
97Recurrent lower respiratory tract infections (HP:0002783)2.13368469
98Abnormality of the endocardium (HP:0004306)2.12801622
99Myocardial infarction (HP:0001658)2.12777364
100Premature loss of primary teeth (HP:0006323)2.12203542
101Abnormality of iron homeostasis (HP:0011031)2.11332577
102Glomerulopathy (HP:0100820)2.11242407
103Abnormality of T cell physiology (HP:0011840)2.08442356
104Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07606549
105Acne (HP:0001061)2.07195885
106Abnormality of the pericardium (HP:0001697)2.07159125
107Abnormality of cells of the lymphoid lineage (HP:0012140)2.07074202
108Abnormal platelet volume (HP:0011876)2.06562783
109Arterial thrombosis (HP:0004420)2.06202441
110Albinism (HP:0001022)2.04653707
111Vertigo (HP:0002321)2.04620505
112Basal ganglia calcification (HP:0002135)2.03653038
113Abnormality of the prostate (HP:0008775)2.00196145
114Progressive neurologic deterioration (HP:0002344)2.00051588
115Chest pain (HP:0100749)1.99671690
116Keratitis (HP:0000491)1.99309007
117Sepsis (HP:0100806)1.99190632
118Abnormality of the thoracic spine (HP:0100711)1.98930302
119Pulmonary infiltrates (HP:0002113)1.96209609
120Skin ulcer (HP:0200042)1.96081307
121Asymmetric septal hypertrophy (HP:0001670)1.95877604
122Abnormality of the lumbar spine (HP:0100712)1.95840666
123Polyneuropathy (HP:0001271)1.92406039
124Cheilitis (HP:0100825)1.91016887
125Slow saccadic eye movements (HP:0000514)1.90153649
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.89920748
127J-shaped sella turcica (HP:0002680)1.89867627
128Upper motor neuron abnormality (HP:0002127)1.88636993
129Abnormality of the nasal mucosa (HP:0000433)1.88246640
130Pathologic fracture (HP:0002756)1.86642493
131Polycythemia (HP:0001901)1.85900315
132Hemoptysis (HP:0002105)1.85291150
133Increased IgE level (HP:0003212)1.83764680
134Joint hemorrhage (HP:0005261)1.81183868
135Segmental peripheral demyelination/remyelination (HP:0003481)1.80728463
136Hypermelanotic macule (HP:0001034)1.80095149
137Eosinophilia (HP:0001880)1.79475807
138Keratoconjunctivitis sicca (HP:0001097)1.79354685
139Hypergammaglobulinemia (HP:0010702)1.77959548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.65194365
2IRAK43.64781816
3MAP4K13.44701107
4ERN13.13563905
5RIPK42.81630851
6CSK2.65285419
7TYK22.52611902
8FGR2.41186505
9KIT2.34951178
10TGFBR22.33028114
11MAP2K32.23594750
12BTK2.23401833
13STK102.16829902
14TBK12.11284593
15MATK2.10600643
16PRPF4B2.07351992
17FES2.06959357
18CSF1R2.04460071
19CLK11.99350411
20EPHB11.97523756
21TEC1.88941192
22IRAK31.87105739
23ZAP701.77222131
24MAP3K61.74931522
25HCK1.63056188
26TRPM71.56249440
27MAP3K111.49863024
28TAOK31.48104933
29TRIB31.46151677
30MAP3K141.42954333
31SIK31.42361741
32SYK1.37968285
33IKBKB1.36954582
34LYN1.31931693
35GRK61.31020538
36MAP3K11.30522042
37KSR21.27777800
38PAK41.20213394
39PIM21.19195049
40PIM11.18428065
41CAMK1D1.10019992
42TXK1.07719512
43LRRK21.07470449
44JAK31.06392633
45JAK11.06370992
46LCK1.06159753
47MARK21.05857940
48IKBKE1.05387465
49ITK1.03905099
50MAPK151.03714359
51PRKD21.02453574
52NEK90.98022283
53IRAK10.97685300
54PKN20.95128927
55CDK190.94085167
56RIPK10.92416892
57JAK20.90704123
58IRAK20.90504996
59RPS6KA60.90222348
60RPS6KA40.85366043
61RPS6KC10.85245923
62RPS6KL10.85245923
63MAP3K30.79107787
64DAPK10.75432155
65CDK60.74936203
66PTK60.73930545
67TTN0.72375755
68YES10.71078617
69GRK70.70974895
70TESK20.70114317
71MARK30.70061093
72MAP2K40.69824437
73MAP3K100.69515810
74CDK120.68691260
75BMPR20.68588215
76MAP3K70.68369258
77SMG10.68032541
78MAPKAPK20.64562312
79MAPK40.64506639
80MAPK120.64351001
81PTK2B0.63495806
82EGFR0.63263436
83MAP3K20.63040179
84CDC42BPA0.62796453
85BMX0.62720553
86STK110.62597367
87DAPK20.61997770
88MAP3K50.61267420
89ICK0.59460637
90DYRK1B0.59372090
91STK40.59052962
92MAP3K130.58806681
93TNK20.57416676
94PRKCD0.56545379
95MAPK70.56143027
96CAMK1G0.55570963
97FLT30.54698356
98SIK20.53735716
99CHUK0.53324747
100KDR0.52189620
101EPHA30.51975793
102PRKCQ0.51752989
103CDK70.49606494
104ABL10.49406969
105STK380.48995175
106ERBB30.48899341
107SGK30.48813297
108SIK10.48413488
109MAP2K60.46019947
110MAP3K80.44445219
111MAP3K120.44297108
112KSR10.41654973
113EEF2K0.41498329
114RET0.41070053
115FGFR30.40523774
116MAPK110.40469476
117FGFR40.40148904
118PRKG20.39615880
119RAF10.38914523
120PRKCZ0.36349185
121ALK0.36045357
122SCYL20.35870697
123CAMKK10.35259061
124CAMKK20.34980231
125NLK0.34502180
126FYN0.34405368
127PDK10.34246990
128RPS6KA20.33328741
129NME20.31672850
130PIK3CG0.29703720
131TAOK10.29145330
132TAOK20.28819478
133RPS6KA10.28380601
134NEK20.28196532
135PDPK10.26560656
136PRKCH0.26326550
137CDK40.26317663
138HIPK20.25826942

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.40030877
2Leishmaniasis_Homo sapiens_hsa051403.53248485
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.23397038
4Other glycan degradation_Homo sapiens_hsa005113.02500259
5Osteoclast differentiation_Homo sapiens_hsa043802.64514424
6Lysosome_Homo sapiens_hsa041422.53953209
7B cell receptor signaling pathway_Homo sapiens_hsa046622.35450814
8Pertussis_Homo sapiens_hsa051332.30569870
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.20405687
10Tuberculosis_Homo sapiens_hsa051522.17354528
11Autoimmune thyroid disease_Homo sapiens_hsa053202.15814090
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.07136243
13Legionellosis_Homo sapiens_hsa051342.04774593
14Shigellosis_Homo sapiens_hsa051311.88433114
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.75482692
16Type I diabetes mellitus_Homo sapiens_hsa049401.73852272
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67191627
18Phagosome_Homo sapiens_hsa041451.65395704
19Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.62605993
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.60918301
21Measles_Homo sapiens_hsa051621.58277500
22Hematopoietic cell lineage_Homo sapiens_hsa046401.57583319
23Salmonella infection_Homo sapiens_hsa051321.53955186
24Chemokine signaling pathway_Homo sapiens_hsa040621.52903367
25Malaria_Homo sapiens_hsa051441.51885152
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49749454
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46493235
28Antigen processing and presentation_Homo sapiens_hsa046121.44743320
29Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44193839
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42237128
31Toxoplasmosis_Homo sapiens_hsa051451.42143380
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33992208
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33252555
34Apoptosis_Homo sapiens_hsa042101.25316925
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.24148868
36Herpes simplex infection_Homo sapiens_hsa051681.23517460
37Influenza A_Homo sapiens_hsa051641.22793060
38Caffeine metabolism_Homo sapiens_hsa002321.22004034
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20443322
40Hepatitis B_Homo sapiens_hsa051611.18480163
41Acute myeloid leukemia_Homo sapiens_hsa052211.17836025
42Complement and coagulation cascades_Homo sapiens_hsa046101.17517144
43Platelet activation_Homo sapiens_hsa046111.13407176
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12875170
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.11955138
46Primary immunodeficiency_Homo sapiens_hsa053401.09835791
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08969811
48TNF signaling pathway_Homo sapiens_hsa046681.06229061
49Asthma_Homo sapiens_hsa053101.05962623
50Chronic myeloid leukemia_Homo sapiens_hsa052201.05332315
51Base excision repair_Homo sapiens_hsa034101.04447599
52Pancreatic cancer_Homo sapiens_hsa052121.01792172
53DNA replication_Homo sapiens_hsa030301.01301131
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00791826
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00005406
56Viral myocarditis_Homo sapiens_hsa054160.97115386
57Rheumatoid arthritis_Homo sapiens_hsa053230.90801254
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88031253
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85157964
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.82883039
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80535612
62VEGF signaling pathway_Homo sapiens_hsa043700.79012743
63Renal cell carcinoma_Homo sapiens_hsa052110.77852731
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77803670
65Mismatch repair_Homo sapiens_hsa034300.75404572
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71072994
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.69697047
68Hepatitis C_Homo sapiens_hsa051600.69047136
69Epstein-Barr virus infection_Homo sapiens_hsa051690.68272365
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67652580
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67379188
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.66916004
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.65797747
74Amoebiasis_Homo sapiens_hsa051460.64536116
75Graft-versus-host disease_Homo sapiens_hsa053320.64384980
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63862340
77Endocytosis_Homo sapiens_hsa041440.62968058
78Notch signaling pathway_Homo sapiens_hsa043300.62167013
79Pentose phosphate pathway_Homo sapiens_hsa000300.62067528
80FoxO signaling pathway_Homo sapiens_hsa040680.62062626
81T cell receptor signaling pathway_Homo sapiens_hsa046600.61379334
82GnRH signaling pathway_Homo sapiens_hsa049120.58587931
83Non-small cell lung cancer_Homo sapiens_hsa052230.57625918
84Choline metabolism in cancer_Homo sapiens_hsa052310.57615265
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57025619
86Viral carcinogenesis_Homo sapiens_hsa052030.56804223
87Regulation of autophagy_Homo sapiens_hsa041400.56230610
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55982046
89Endometrial cancer_Homo sapiens_hsa052130.55786684
90Dorso-ventral axis formation_Homo sapiens_hsa043200.53132212
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53013065
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51326986
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51151803
94Colorectal cancer_Homo sapiens_hsa052100.48259301
95Type II diabetes mellitus_Homo sapiens_hsa049300.48013972
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.47616085
97Rap1 signaling pathway_Homo sapiens_hsa040150.47236555
98MAPK signaling pathway_Homo sapiens_hsa040100.45479644
99African trypanosomiasis_Homo sapiens_hsa051430.45404325
100Collecting duct acid secretion_Homo sapiens_hsa049660.44632733
101Allograft rejection_Homo sapiens_hsa053300.43370294
102HIF-1 signaling pathway_Homo sapiens_hsa040660.42938726
103Small cell lung cancer_Homo sapiens_hsa052220.42170129
104Inositol phosphate metabolism_Homo sapiens_hsa005620.41975027
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40035304
106Homologous recombination_Homo sapiens_hsa034400.38669646
107p53 signaling pathway_Homo sapiens_hsa041150.37941408
108Adherens junction_Homo sapiens_hsa045200.36875331
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35173453
110ABC transporters_Homo sapiens_hsa020100.34246923
111Estrogen signaling pathway_Homo sapiens_hsa049150.33852822
112Proteoglycans in cancer_Homo sapiens_hsa052050.33034106
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31474252
114mTOR signaling pathway_Homo sapiens_hsa041500.30298319
115HTLV-I infection_Homo sapiens_hsa051660.29913791
116Prolactin signaling pathway_Homo sapiens_hsa049170.29021493
117Insulin resistance_Homo sapiens_hsa049310.29019260
118N-Glycan biosynthesis_Homo sapiens_hsa005100.28641400
119Renin-angiotensin system_Homo sapiens_hsa046140.27991601
120Bladder cancer_Homo sapiens_hsa052190.27609295
121Starch and sucrose metabolism_Homo sapiens_hsa005000.27183270
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26719489
123Galactose metabolism_Homo sapiens_hsa000520.24274706
124Prion diseases_Homo sapiens_hsa050200.24244145

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »