NFAT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of pigment cell differentiation (GO:0050932)3.81824854
2cellular response to ethanol (GO:0071361)3.42189656
3positive regulation of developmental pigmentation (GO:0048087)3.40691634
4hypotonic response (GO:0006971)3.34918939
5cytoplasmic mRNA processing body assembly (GO:0033962)3.29198687
6pericardium development (GO:0060039)3.28586711
7phospholipid translocation (GO:0045332)3.27401632
8lipid translocation (GO:0034204)3.27401632
9monoubiquitinated protein deubiquitination (GO:0035520)3.23605811
10histone H3-K4 trimethylation (GO:0080182)3.13318549
11phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.10136665
12iron ion import (GO:0097286)2.95022152
13embryonic process involved in female pregnancy (GO:0060136)2.82985606
14endocardial cushion development (GO:0003197)2.81393370
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81125663
16negative regulation of translation, ncRNA-mediated (GO:0040033)2.81125663
17regulation of translation, ncRNA-mediated (GO:0045974)2.81125663
18growth hormone receptor signaling pathway (GO:0060396)2.79198949
19definitive hemopoiesis (GO:0060216)2.74495501
20SMAD protein complex assembly (GO:0007183)2.74334383
21import into cell (GO:0098657)2.74001978
22regulation of establishment of cell polarity (GO:2000114)2.71260563
23insulin-like growth factor receptor signaling pathway (GO:0048009)2.67591001
24regulation of transforming growth factor beta2 production (GO:0032909)2.66916613
25negative regulation of neurotransmitter secretion (GO:0046929)2.66359230
26positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.66104752
27cellular response to growth hormone stimulus (GO:0071378)2.64938713
28establishment of protein localization to Golgi (GO:0072600)2.64112855
29histone H3-K36 demethylation (GO:0070544)2.63019403
30regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.62810720
31interleukin-6-mediated signaling pathway (GO:0070102)2.51224265
32axon extension involved in axon guidance (GO:0048846)2.48450214
33neuron projection extension involved in neuron projection guidance (GO:1902284)2.48450214
34regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.47386967
35hemidesmosome assembly (GO:0031581)2.46469918
36skin morphogenesis (GO:0043589)2.45492219
37protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.37781645
38nuclear pore complex assembly (GO:0051292)2.35836381
39negative regulation of DNA repair (GO:0045738)2.34852170
40early endosome to late endosome transport (GO:0045022)2.33897320
41regulation of establishment or maintenance of cell polarity (GO:0032878)2.33840860
42regulation of histone H3-K27 methylation (GO:0061085)2.33731024
43regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.33713325
44positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.33713325
45positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.33643933
46regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.33643933
47negative regulation of smooth muscle cell differentiation (GO:0051151)2.31554451
48chondrocyte proliferation (GO:0035988)2.30744313
49vascular endothelial growth factor signaling pathway (GO:0038084)2.30505351
50histone H3-K4 methylation (GO:0051568)2.28645145
51regulation of interleukin-12 biosynthetic process (GO:0045075)2.26578111
52regulation of clathrin-mediated endocytosis (GO:2000369)2.25907748
53nucleus localization (GO:0051647)2.25845396
54protein heterotrimerization (GO:0070208)2.24537255
55lymph vessel development (GO:0001945)2.23726641
56negative regulation of complement activation (GO:0045916)2.22499025
57positive regulation of natural killer cell differentiation (GO:0032825)2.22197758
58radial glial cell differentiation (GO:0060019)2.21926266
59mesodermal cell differentiation (GO:0048333)2.21169487
60mesenchymal-epithelial cell signaling (GO:0060638)2.20616071
61protein K48-linked deubiquitination (GO:0071108)2.20573658
62regulation of alkaline phosphatase activity (GO:0010692)2.20428771
63negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.19911760
64negative regulation of T-helper cell differentiation (GO:0045623)2.19911760
65embryonic hemopoiesis (GO:0035162)2.19183842
66desmosome organization (GO:0002934)2.18275665
67positive regulation of p38MAPK cascade (GO:1900745)2.17098162
68embryonic viscerocranium morphogenesis (GO:0048703)2.15415757
69positive regulation of protein import into nucleus, translocation (GO:0033160)2.14903797
70antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.14876457
71regulation of hippo signaling (GO:0035330)2.14433265
72negative regulation of fatty acid transport (GO:2000192)2.14172667
73face morphogenesis (GO:0060325)2.13833363
74regulation of necroptotic process (GO:0060544)2.13128164
75heart morphogenesis (GO:0003007)2.13009516
76coronary vasculature morphogenesis (GO:0060977)2.12999822
77protein targeting to lysosome (GO:0006622)2.12947177
78establishment of protein localization to vacuole (GO:0072666)2.12947177
79protein targeting to vacuole (GO:0006623)2.12947177
80regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.12942362
81protein targeting to Golgi (GO:0000042)2.12166377
82regulation of membrane lipid distribution (GO:0097035)2.11839325
83negative regulation of protein activation cascade (GO:2000258)2.11777101
84Notch signaling involved in heart development (GO:0061314)2.11565440
85embryonic camera-type eye morphogenesis (GO:0048596)2.11506450
86sequestering of extracellular ligand from receptor (GO:0035581)2.11240544
87collagen fibril organization (GO:0030199)2.11233916
88cell adhesion mediated by integrin (GO:0033627)2.09836316
89positive regulation of hormone biosynthetic process (GO:0046886)2.08717733
90blood vessel maturation (GO:0001955)2.07262657
91peptidyl-threonine phosphorylation (GO:0018107)2.07014471
92regulation of RNA export from nucleus (GO:0046831)2.06697285
93regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.05671122
94mesenchymal cell differentiation (GO:0048762)2.04475380
95aorta morphogenesis (GO:0035909)2.03694628
96macroautophagy (GO:0016236)2.03316799
97cell proliferation involved in metanephros development (GO:0072203)2.03188418
98positive regulation of gamma-delta T cell activation (GO:0046645)2.02862139
99positive regulation of mRNA catabolic process (GO:0061014)2.01221563
100I-kappaB phosphorylation (GO:0007252)2.00638861
101hippo signaling (GO:0035329)2.00218988
102regulation of NFAT protein import into nucleus (GO:0051532)1.99257461
103ovulation from ovarian follicle (GO:0001542)1.99237846
104metanephric mesenchyme development (GO:0072075)1.99010335
105embryonic retina morphogenesis in camera-type eye (GO:0060059)1.98833841
106Golgi to endosome transport (GO:0006895)1.98812807
107positive regulation of histone deacetylation (GO:0031065)1.98587210
108peptidyl-lysine trimethylation (GO:0018023)1.97728269
109regulation of T cell tolerance induction (GO:0002664)1.96682743
110ovulation (GO:0030728)1.96392978
111glucocorticoid receptor signaling pathway (GO:0042921)1.96226107
112positive regulation of fibroblast migration (GO:0010763)1.96055369
113positive regulation of cardiac muscle hypertrophy (GO:0010613)1.94980940
114positive regulation of muscle hypertrophy (GO:0014742)1.94980940
115fibroblast migration (GO:0010761)1.94919080
116ganglion development (GO:0061548)1.94458009
117platelet-derived growth factor receptor signaling pathway (GO:0048008)1.93930313
118cell proliferation involved in kidney development (GO:0072111)1.93859933
119hepatocyte apoptotic process (GO:0097284)1.93836218
120peptidyl-threonine modification (GO:0018210)1.93578363
121gland morphogenesis (GO:0022612)1.93126195
122histone lysine demethylation (GO:0070076)1.92445353
123pathway-restricted SMAD protein phosphorylation (GO:0060389)1.92341410
124histone H3-K9 demethylation (GO:0033169)1.92154922
125histone demethylation (GO:0016577)1.91862060
126substrate-dependent cell migration (GO:0006929)1.91810789
127positive regulation of astrocyte differentiation (GO:0048711)1.91444336
128regulation of protein polyubiquitination (GO:1902914)1.90921677
129regulation of cardiac muscle hypertrophy (GO:0010611)1.90820562
130smooth muscle tissue development (GO:0048745)1.90807192
131regulation of energy homeostasis (GO:2000505)1.90545040
132positive regulation of mesenchymal cell proliferation (GO:0002053)1.90474643
133retina vasculature morphogenesis in camera-type eye (GO:0061299)1.90008027
134peptidyl-lysine methylation (GO:0018022)1.88873975
135cellular response to interferon-alpha (GO:0035457)1.88847521
136negative regulation of myoblast differentiation (GO:0045662)1.88748511
137bone trabecula formation (GO:0060346)1.88487270
138NLS-bearing protein import into nucleus (GO:0006607)1.88374094
139germinal center formation (GO:0002467)1.87857750
140male sex determination (GO:0030238)1.87746733
141corticosteroid receptor signaling pathway (GO:0031958)1.87584242
142regulation of p38MAPK cascade (GO:1900744)1.86871033
143regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)1.86742578
144chondrocyte development (GO:0002063)1.86324539
145regulation of mRNA catabolic process (GO:0061013)1.85293591
146endodermal cell differentiation (GO:0035987)1.85199882
147cell-substrate junction assembly (GO:0007044)1.83294068
148negative regulation of chondrocyte differentiation (GO:0032331)1.82581978
149kidney mesenchyme development (GO:0072074)1.81199712
150morphogenesis of an epithelial sheet (GO:0002011)1.80760104
151negative regulation of keratinocyte proliferation (GO:0010839)1.79873130
152exocrine pancreas development (GO:0031017)1.79487534
153negative regulation of osteoblast proliferation (GO:0033689)1.78256766
154regulation of mesenchymal cell proliferation (GO:0010464)1.78042479
155histone lysine methylation (GO:0034968)1.77572395
156chondrocyte differentiation (GO:0002062)1.77043190
157retrograde transport, vesicle recycling within Golgi (GO:0000301)1.76706217
158lung lobe morphogenesis (GO:0060463)1.75623603
159branching involved in salivary gland morphogenesis (GO:0060445)1.75094316
160response to fluid shear stress (GO:0034405)1.74838144
161JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)1.74618444
162positive regulation of cardiac muscle cell differentiation (GO:2000727)1.74370136
163cellular response to vascular endothelial growth factor stimulus (GO:0035924)1.74081488
164regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.73623404
165T-helper cell differentiation (GO:0042093)1.73568011
166CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)1.73568011
167interkinetic nuclear migration (GO:0022027)1.73534469
168cellular response to vitamin D (GO:0071305)1.73415703
169lymphangiogenesis (GO:0001946)1.73408031

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.19187717
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.58967749
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.44683282
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25003410
5* SMAD_19615063_ChIP-ChIP_OVARY_Human2.14155548
6ZNF217_24962896_ChIP-Seq_MCF-7_Human2.07777360
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.06055581
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99273753
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95692786
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86553820
11CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85252895
12GBX2_23144817_ChIP-Seq_PC3_Human1.69245353
13TRIM28_21343339_ChIP-Seq_HEK293_Human1.64867583
14VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64505121
15AHR_22903824_ChIP-Seq_MCF-7_Human1.62946301
16EGR1_19374776_ChIP-ChIP_THP-1_Human1.62896657
17TP53_16413492_ChIP-PET_HCT116_Human1.60921043
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54554353
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.50197762
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49597342
21GATA2_21666600_ChIP-Seq_HMVEC_Human1.48213100
22ARNT_22903824_ChIP-Seq_MCF-7_Human1.46646475
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.43182168
24RUNX_20019798_ChIP-Seq_JUKART_Human1.43059949
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42204901
26* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41065492
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.40362628
28GATA1_22025678_ChIP-Seq_K562_Human1.39731668
29SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39345912
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.39107059
31* CJUN_26792858_Chip-Seq_BT549_Human1.36837759
32TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.36722707
33DROSHA_22980978_ChIP-Seq_HELA_Human1.36293521
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.35157207
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.34477007
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.34094228
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32662694
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31264405
39ESR1_21235772_ChIP-Seq_MCF-7_Human1.31200335
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28939302
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.26526610
42TP53_18474530_ChIP-ChIP_U2OS_Human1.26245415
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25249432
44TCF4_18268006_ChIP-ChIP_LS174T_Human1.24572892
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.23962384
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23779924
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23779924
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.22987554
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22751035
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22072967
51RXR_22108803_ChIP-Seq_LS180_Human1.20155432
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18535916
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18410967
54* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18329471
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17831038
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.17425549
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17217508
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.16717540
59CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16282766
60ISL1_27105846_Chip-Seq_CPCs_Mouse1.16206670
61TP63_23658742_ChIP-Seq_EP156T_Human1.16111410
62VDR_24787735_ChIP-Seq_THP-1_Human1.15606852
63NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15226099
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15226099
65SMAD4_21799915_ChIP-Seq_A2780_Human1.14873199
66BRD4_25478319_ChIP-Seq_HGPS_Human1.14724890
67* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13911080
68SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13502642
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12737701
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.12697263
71SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11915349
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.11570093
73TAF15_26573619_Chip-Seq_HEK293_Human1.11501653
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11094693
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09845054
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.08734364
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.08095880
78BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08084946
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08016891
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07752006
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07654031
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.07340585
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.06388854
84JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06343317
85SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05873062
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04975312
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04969305
88* AR_21572438_ChIP-Seq_LNCaP_Human1.04933673
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04748517
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04432602
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04432602
92FLI1_27457419_Chip-Seq_LIVER_Mouse1.03677908
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.03242591
94* STAT3_23295773_ChIP-Seq_U87_Human1.01631102
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00974501
96* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00032185
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99717488
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99149492
99TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98474695
100* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97897785
101MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96930957
102PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96379813
103* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96173592
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95511249
105PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93977021
106* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93928950
107NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93714438
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93428350
109* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93408482
110NANOG_18555785_Chip-Seq_ESCs_Mouse0.93090687
111* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.93072160
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.91871338
113P300_19829295_ChIP-Seq_ESCs_Human0.91485007
114KDM2B_26808549_Chip-Seq_K562_Human0.91479340
115NR3C1_23031785_ChIP-Seq_PC12_Mouse0.91475218
116JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90924134
117FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90407878
118JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90295339
119CDX2_22108803_ChIP-Seq_LS180_Human0.90145442
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.89937997
121* TCF4_23295773_ChIP-Seq_U87_Human0.89390720
122POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89241946
123GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88839398
124* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88601434
125FOXA2_19822575_ChIP-Seq_HepG2_Human0.88252314
126* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.88235014
127EZH2_27304074_Chip-Seq_ESCs_Mouse0.88200421
128BCAT_22108803_ChIP-Seq_LS180_Human0.88190780
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87949299
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86833070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.10368725
2MP0008057_abnormal_DNA_replication3.00083918
3MP0003045_fibrosis2.91523829
4MP0003300_gastrointestinal_ulcer2.75744979
5MP0005503_abnormal_tendon_morphology2.75164159
6MP0008438_abnormal_cutaneous_collagen2.65903595
7MP0003950_abnormal_plasma_membrane2.39581851
8MP0004272_abnormal_basement_membrane2.29051584
9MP0005275_abnormal_skin_tensile2.07199893
10MP0005623_abnormal_meninges_morphology2.03498326
11MP0005076_abnormal_cell_differentiation1.98340780
12MP0006054_spinal_hemorrhage1.96284378
13MP0003279_aneurysm1.95656435
14MP0003091_abnormal_cell_migration1.93770319
15MP0002009_preneoplasia1.88767101
16MP0001879_abnormal_lymphatic_vessel1.87944918
17MP0001299_abnormal_eye_distance/1.85102425
18MP0001958_emphysema1.82075769
19MP0002166_altered_tumor_susceptibility1.74474110
20MP0002254_reproductive_system_inflammat1.71825658
21MP0009278_abnormal_bone_marrow1.71175487
22MP0003890_abnormal_embryonic-extraembry1.69833020
23MP0010368_abnormal_lymphatic_system1.68644010
24MP0004043_abnormal_pH_regulation1.68536434
25MP0005367_renal/urinary_system_phenotyp1.67091503
26MP0000516_abnormal_urinary_system1.67091503
27MP0009780_abnormal_chondrocyte_physiolo1.67061362
28MP0002877_abnormal_melanocyte_morpholog1.65597580
29MP0000733_abnormal_muscle_development1.65459901
30MP0000383_abnormal_hair_follicle1.62899342
31MP0003705_abnormal_hypodermis_morpholog1.56786660
32MP0001346_abnormal_lacrimal_gland1.53895140
33MP0003566_abnormal_cell_adhesion1.51315827
34MP0002168_other_aberrant_phenotype1.48458656
35MP0009115_abnormal_fat_cell1.47923128
36MP0009250_abnormal_appendicular_skeleto1.47845790
37MP0010352_gastrointestinal_tract_polyps1.47582324
38MP0002006_tumorigenesis1.46906543
39MP0003252_abnormal_bile_duct1.46542855
40MP0002896_abnormal_bone_mineralization1.45285231
41MP0000767_abnormal_smooth_muscle1.44018349
42MP0010678_abnormal_skin_adnexa1.40331060
43MP0005248_abnormal_Harderian_gland1.38449885
44MP0004134_abnormal_chest_morphology1.38440604
45MP0005508_abnormal_skeleton_morphology1.38328077
46MP0004264_abnormal_extraembryonic_tissu1.37223385
47MP0005164_abnormal_response_to1.35593108
48MP0003941_abnormal_skin_development1.34813139
49MP0003195_calcinosis1.34140452
50MP0002108_abnormal_muscle_morphology1.33906123
51MP0003787_abnormal_imprinting1.32017682
52MP0003935_abnormal_craniofacial_develop1.31857218
53MP0003385_abnormal_body_wall1.29147675
54MP0002928_abnormal_bile_duct1.28629648
55MP0002998_abnormal_bone_remodeling1.28259099
56MP0002933_joint_inflammation1.25536973
57MP0000428_abnormal_craniofacial_morphol1.25438481
58MP0003183_abnormal_peptide_metabolism1.22215789
59MP0008961_abnormal_basal_metabolism1.20210709
60MP0002060_abnormal_skin_morphology1.18981563
61MP0001348_abnormal_lacrimal_gland1.18293487
62MP0004484_altered_response_of1.16088965
63MP0004883_abnormal_blood_vessel1.15395397
64MP0000534_abnormal_ureter_morphology1.15322886
65MP0001270_distended_abdomen1.14260815
66MP0000432_abnormal_head_morphology1.11665307
67MP0002115_abnormal_skeleton_extremities1.11545263
68MP0004084_abnormal_cardiac_muscle1.10483004
69MP0004808_abnormal_hematopoietic_stem1.10387483
70MP0001915_intracranial_hemorrhage1.10016185
71MP0002925_abnormal_cardiovascular_devel1.09841710
72MP0004130_abnormal_muscle_cell1.08667145
73MP0000163_abnormal_cartilage_morphology1.07712214
74MP0004510_myositis1.07653985
75MP0001851_eye_inflammation1.07118221
76MP0003942_abnormal_urinary_system1.06855961
77MP0003763_abnormal_thymus_physiology1.06382331
78MP0001790_abnormal_immune_system1.03580829
79MP0005387_immune_system_phenotype1.03580829
80MP0005257_abnormal_intraocular_pressure1.02850321
81MP0002109_abnormal_limb_morphology1.01292297
82MP0005187_abnormal_penis_morphology1.00482930
83MP0002177_abnormal_outer_ear1.00338683
84MP0009384_cardiac_valve_regurgitation0.99841569
85MP0000566_synostosis0.98882106
86MP0003828_pulmonary_edema0.97990872
87MP0003755_abnormal_palate_morphology0.96774168
88MP0004947_skin_inflammation0.96158289
89MP0005666_abnormal_adipose_tissue0.94276883
90MP0003115_abnormal_respiratory_system0.93845892
91MP0002971_abnormal_brown_adipose0.93299628
92MP0003453_abnormal_keratinocyte_physiol0.91674454
93MP0002138_abnormal_hepatobiliary_system0.91515765
94MP0003868_abnormal_feces_composition0.90925885
95MP0002116_abnormal_craniofacial_bone0.90817015
96MP0003937_abnormal_limbs/digits/tail_de0.90782069
97MP0005171_absent_coat_pigmentation0.89656054
98MP0005023_abnormal_wound_healing0.88713528
99MP0005670_abnormal_white_adipose0.87141045
100MP0008004_abnormal_stomach_pH0.86808609
101MP0002113_abnormal_skeleton_development0.86413428
102MP0006138_congestive_heart_failure0.86375654
103MP0005375_adipose_tissue_phenotype0.86292409
104MP0005390_skeleton_phenotype0.85100908
105MP0000537_abnormal_urethra_morphology0.83097077
106MP0000762_abnormal_tongue_morphology0.81685352
107MP0000003_abnormal_adipose_tissue0.81566369
108MP0002098_abnormal_vibrissa_morphology0.81217538
109MP0004036_abnormal_muscle_relaxation0.80771335
110MP0001873_stomach_inflammation0.79749324
111MP0000427_abnormal_hair_cycle0.79556650
112MP0000371_diluted_coat_color0.79545526
113MP0002086_abnormal_extraembryonic_tissu0.79125247
114MP0005621_abnormal_cell_physiology0.79092176
115MP0000249_abnormal_blood_vessel0.78431307
116MP0003448_altered_tumor_morphology0.77174300
117MP0000613_abnormal_salivary_gland0.77018633
118MP0010234_abnormal_vibrissa_follicle0.76324234
119MP0002249_abnormal_larynx_morphology0.75690627
120MP0002332_abnormal_exercise_endurance0.75583502
121MP0002396_abnormal_hematopoietic_system0.75160953
122MP0010630_abnormal_cardiac_muscle0.75043056
123MP0004185_abnormal_adipocyte_glucose0.74417381
124MP0002133_abnormal_respiratory_system0.74031516
125MP0005388_respiratory_system_phenotype0.74031516
126MP0005409_darkened_coat_color0.73606630
127MP0002233_abnormal_nose_morphology0.73546571
128MP0003943_abnormal_hepatobiliary_system0.73528359
129MP0004233_abnormal_muscle_weight0.73172433
130MP0003656_abnormal_erythrocyte_physiolo0.73039571
131MP0005310_abnormal_salivary_gland0.72933017
132MP0003795_abnormal_bone_structure0.71615483
133MP0001501_abnormal_sleep_pattern0.71291283
134* MP0001784_abnormal_fluid_regulation0.71070886
135MP0001614_abnormal_blood_vessel0.70783893
136MP0002128_abnormal_blood_circulation0.70509210
137MP0002932_abnormal_joint_morphology0.70317652
138MP0002697_abnormal_eye_size0.70194657
139MP0003283_abnormal_digestive_organ0.70053275
140MP0003690_abnormal_glial_cell0.69220446
141MP0004381_abnormal_hair_follicle0.67346168
142MP0002405_respiratory_system_inflammati0.66967313

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the nasal septum (HP:0000419)3.04107676
2Abnormality of the fingertips (HP:0001211)2.94063626
3Syringomyelia (HP:0003396)2.92995557
4Spinal cord lesions (HP:0100561)2.92995557
5Hypoplastic ischia (HP:0003175)2.78273413
6Broad metatarsal (HP:0001783)2.75039522
7Macroorchidism (HP:0000053)2.74189296
8Atrophic scars (HP:0001075)2.73963511
9Vertebral arch anomaly (HP:0008438)2.72546673
10Aortic aneurysm (HP:0004942)2.67846274
11Shallow orbits (HP:0000586)2.65029981
12Absent frontal sinuses (HP:0002688)2.62055662
13Narrow palate (HP:0000189)2.61752755
14Lip pit (HP:0100267)2.60750955
15Urethral obstruction (HP:0000796)2.56184250
16Abnormality of the ischium (HP:0003174)2.53850059
17Cerebral aneurysm (HP:0004944)2.46880864
18Papillary thyroid carcinoma (HP:0002895)2.39312319
19Short 4th metacarpal (HP:0010044)2.37908633
20Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.37908633
21Protrusio acetabuli (HP:0003179)2.29624349
22Dysmetric saccades (HP:0000641)2.27849872
23Bell-shaped thorax (HP:0001591)2.24986009
24Follicular hyperkeratosis (HP:0007502)2.18494539
25Acute myeloid leukemia (HP:0004808)2.17753367
26Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.17614042
27Aortic dissection (HP:0002647)2.16084291
28Heterotopia (HP:0002282)2.16076008
29Trigonocephaly (HP:0000243)2.15948797
30Papilledema (HP:0001085)2.14134434
31Long eyelashes (HP:0000527)2.11182541
32Midline defect of the nose (HP:0004122)2.09533355
33Ankle contracture (HP:0006466)2.09450177
34Sparse lateral eyebrow (HP:0005338)2.07949342
35Milia (HP:0001056)2.07731130
36Obstructive sleep apnea (HP:0002870)2.06909968
37Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.05693276
38Fair hair (HP:0002286)2.01340287
39Mitral valve prolapse (HP:0001634)2.01182765
40Flat acetabular roof (HP:0003180)2.01180840
41Tapered finger (HP:0001182)2.00858587
42Abnormality of incisor morphology (HP:0011063)1.97566189
43Truncal obesity (HP:0001956)1.97290775
44Premature rupture of membranes (HP:0001788)1.96916501
45Widely spaced teeth (HP:0000687)1.96748747
46Mesomelia (HP:0003027)1.95814002
47Cubitus valgus (HP:0002967)1.94573098
48Osteolytic defects of the hand bones (HP:0009699)1.91281092
49Osteolytic defects of the phalanges of the hand (HP:0009771)1.91281092
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.90596337
51Hyperkalemia (HP:0002153)1.90262112
52Broad face (HP:0000283)1.90149810
53Striae distensae (HP:0001065)1.87146382
54Genetic anticipation (HP:0003743)1.87048768
55Abnormality of secondary sexual hair (HP:0009888)1.86389213
56Abnormality of the axillary hair (HP:0100134)1.86389213
57Coarse hair (HP:0002208)1.85538173
58Dilatation of the ascending aorta (HP:0005111)1.85127536
59Aneurysm (HP:0002617)1.82608785
60Limited elbow extension (HP:0001377)1.82212018
61Right ventricular cardiomyopathy (HP:0011663)1.82100247
62Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.81579925
63Hematochezia (HP:0002573)1.81450752
64Acanthocytosis (HP:0001927)1.80149613
65Neonatal short-limb short stature (HP:0008921)1.79499022
66Abnormality of the frontal sinuses (HP:0002687)1.79062573
67Submucous cleft hard palate (HP:0000176)1.79047058
68Vascular tortuosity (HP:0004948)1.78601251
69Broad ribs (HP:0000885)1.78408729
70Arterial tortuosity (HP:0005116)1.78336300
71Flared iliac wings (HP:0002869)1.77628887
72Persistence of primary teeth (HP:0006335)1.77444789
73Peritonitis (HP:0002586)1.77398312
74Spontaneous hematomas (HP:0007420)1.77223789
75Distal lower limb amyotrophy (HP:0008944)1.77193368
76Abnormality of the wing of the ilium (HP:0011867)1.76200265
77Progressive cerebellar ataxia (HP:0002073)1.75497334
78Generalized hypopigmentation of hair (HP:0011358)1.74697325
79Volvulus (HP:0002580)1.74010455
80Spondylolisthesis (HP:0003302)1.73317630
81Abnormality of the parietal bone (HP:0002696)1.73153974
82Limited hip movement (HP:0008800)1.72381964
83Bladder diverticulum (HP:0000015)1.72210753
84Thickened calvaria (HP:0002684)1.71639001
85Curly hair (HP:0002212)1.71550877
86Protruding tongue (HP:0010808)1.71468036
87Portal hypertension (HP:0001409)1.70417990
88Blue irides (HP:0000635)1.70154131
89Increased number of teeth (HP:0011069)1.70094641
90Abnormality of the epiphyses of the hand (HP:0005924)1.69619584
91Esophageal varix (HP:0002040)1.68199518
92Fragile skin (HP:0001030)1.66672085
93Aplasia cutis congenita (HP:0001057)1.66596129
94Dislocated radial head (HP:0003083)1.66539418
95Menorrhagia (HP:0000132)1.66235860
96Subacute progressive viral hepatitis (HP:0006572)1.65282343
97Thick nail (HP:0001805)1.64453046
98Low anterior hairline (HP:0000294)1.64012822
99Abnormality of the common coagulation pathway (HP:0010990)1.63762543
100Pulmonary artery stenosis (HP:0004415)1.63523231
101Cranial hyperostosis (HP:0004437)1.63065575
102Neoplasm of the heart (HP:0100544)1.63035974
103Exostoses (HP:0100777)1.62813043
104Mitral stenosis (HP:0001718)1.62630410
105Short chin (HP:0000331)1.61679422
106Ureteral obstruction (HP:0006000)1.61266948
107Febrile seizures (HP:0002373)1.61089552
108Lower limb amyotrophy (HP:0007210)1.60807718
109Hypoplasia of the iris (HP:0007676)1.60761596
110Abnormality of the right ventricle (HP:0001707)1.60226094
111Cervical subluxation (HP:0003308)1.59182291
112Stomach cancer (HP:0012126)1.58580655
113Epiphyseal dysplasia (HP:0002656)1.58445016
114Craniofacial hyperostosis (HP:0004493)1.58116076
115Aplasia involving bones of the upper limbs (HP:0009823)1.57889541
116Aplasia of the phalanges of the hand (HP:0009802)1.57889541
117Aplasia involving bones of the extremities (HP:0009825)1.57889541
118Enlarged penis (HP:0000040)1.57537195
119Spinal rigidity (HP:0003306)1.57492341
120Hypoplastic labia majora (HP:0000059)1.57217445
121Bronchomalacia (HP:0002780)1.57151333
122Joint laxity (HP:0001388)1.56727790
123Protruding ear (HP:0000411)1.56609714
124Abnormality of the 4th metacarpal (HP:0010012)1.56441878
125Wide anterior fontanel (HP:0000260)1.56419818
126Pulmonic stenosis (HP:0001642)1.56393221
127Hyperventilation (HP:0002883)1.56032585
128Abnormality of the radial head (HP:0003995)1.55189758
129Broad thumb (HP:0011304)1.54434328
130Soft skin (HP:0000977)1.54398817
131Mildly elevated creatine phosphokinase (HP:0008180)1.54268141
132Oligodontia (HP:0000677)1.54227569
133Ankyloglossia (HP:0010296)1.53916146
134Abnormality of the labia majora (HP:0012881)1.53912458
135Abnormality of chloride homeostasis (HP:0011422)1.53693819
136Wormian bones (HP:0002645)1.53551644
137Laryngomalacia (HP:0001601)1.52758675
138Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.52695903
139Overgrowth (HP:0001548)1.52254288
140Hypoplasia of the maxilla (HP:0000327)1.52128372
141Abnormality of the hepatic vasculature (HP:0006707)1.52083073
142Abnormality of the distal phalanx of the thumb (HP:0009617)1.52052418
143Smooth philtrum (HP:0000319)1.51923844
144Thick eyebrow (HP:0000574)1.51777666
145Hypoplastic nipples (HP:0002557)1.51510844
146Gaze-evoked nystagmus (HP:0000640)1.51158681
147Deep philtrum (HP:0002002)1.50675886
148Urinary bladder sphincter dysfunction (HP:0002839)1.48857576
149Supernumerary ribs (HP:0005815)1.48084326
150Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.48058942
151Type 1 muscle fiber predominance (HP:0003803)1.47910648
152Ureteral stenosis (HP:0000071)1.47566910
153Elfin facies (HP:0004428)1.47477810
154Scapular winging (HP:0003691)1.46930466
155Abnormality of the humeroradial joint (HP:0100744)1.46734073
156Asymmetry of the thorax (HP:0001555)1.46719001
157Deviation of the hallux (HP:0010051)1.46430501
158Disproportionate tall stature (HP:0001519)1.43551110

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.22782332
2LATS12.94414111
3INSRR2.62017817
4CAMK1G2.60231323
5BRD42.53109267
6SIK12.32731518
7CAMK1D2.32464879
8RIPK12.29383552
9MAP3K142.13235761
10DDR22.06830689
11EPHA31.92833478
12FGFR31.84150605
13STK38L1.81210507
14JAK11.78262195
15PDGFRA1.77769179
16WNK11.75101629
17NUAK11.73319751
18LATS21.68708614
19STK391.64161787
20EPHB11.61641235
21MST1R1.58763582
22JAK31.53088588
23DMPK1.52926627
24ICK1.49281058
25TTN1.44997958
26MELK1.44816412
27FRK1.40549855
28SIK21.39192576
29CHUK1.38898729
30PDGFRB1.37004479
31FGFR21.35706914
32ACVR1B1.33888494
33STK31.33875834
34PTK61.33073333
35SGK31.28560655
36TGFBR21.28034637
37MET1.22557768
38SGK21.16013788
39TRPM71.15213870
40CDC42BPA1.10732646
41FGFR41.09011666
42MAP3K71.07163308
43MTOR1.05470191
44WNK41.03098323
45IRAK31.02608914
46EEF2K1.02607566
47AKT31.02509001
48SIK30.99875597
49PRKCH0.99456779
50CDK90.99044817
51MYLK0.94214990
52EPHB20.91647936
53TAOK30.91523982
54HIPK20.91126764
55MAP3K20.90886218
56FGFR10.90880170
57PTK20.90815780
58BMX0.90023239
59FER0.89857201
60TXK0.88044137
61NLK0.87268478
62PIK3CG0.85380205
63IKBKE0.82377343
64CDK60.80618566
65MAP3K60.79734248
66IKBKB0.77016005
67SGK10.76538462
68PRKD20.75694289
69ITK0.72281094
70MAPK70.71897621
71TYK20.70565921
72MKNK20.70036724
73ERN10.69553879
74HCK0.67466439
75MAP3K130.66819536
76RET0.66041792
77PAK20.65726110
78PIK3CA0.64446768
79OXSR10.64315439
80ZAK0.62774676
81ERBB30.60702581
82MARK20.59992532
83MAP3K100.59965485
84BMPR20.59844285
85TNIK0.59091574
86SGK2230.58935707
87SGK4940.58935707
88CSK0.57602030
89PRKAA20.57472275
90IRAK10.57256812
91CAMK40.56844039
92NEK90.54641435
93CAMKK20.54535191
94BMPR1B0.53617340
95PTK2B0.52848524
96INSR0.51644140
97TIE10.48408990
98PRPF4B0.48107679
99MAPK10.47578153
100ZAP700.47360070
101PRKD30.46443571
102STK380.46126569
103PRKD10.46011425
104IGF1R0.45849667
105MARK30.44784170
106PRKCE0.43846465
107MAPK110.42999662
108JAK20.42993132
109MAP3K30.41526151
110MAPK100.41153065
111ERBB20.40967790
112YES10.40422858
113TRIB30.40123651
114BRSK20.39597548
115PNCK0.39362616
116NEK60.39172490
117RIPK40.38423005
118PAK30.37936337
119PDPK10.37821176
120PRKCQ0.37819704
121PDK10.37122843
122MAPK80.36689923
123TEC0.36575763
124BLK0.36280149
125NTRK30.36064020
126GSK3A0.35908631
127MAPK140.35442348
128PKN20.35131672
129PRKAA10.35016400
130EPHA20.29056897
131KSR20.27694790
132ERBB40.27329864
133BTK0.26691350

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045121.82411867
2Adherens junction_Homo sapiens_hsa045201.52814340
3Dorso-ventral axis formation_Homo sapiens_hsa043201.46057599
4Focal adhesion_Homo sapiens_hsa045101.45068596
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.39345773
6AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31181665
7Circadian rhythm_Homo sapiens_hsa047101.30206074
8TNF signaling pathway_Homo sapiens_hsa046681.28908044
9Small cell lung cancer_Homo sapiens_hsa052221.28585955
10Proteoglycans in cancer_Homo sapiens_hsa052051.28004580
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.25436601
12Lysine degradation_Homo sapiens_hsa003101.24961495
13Toxoplasmosis_Homo sapiens_hsa051451.23927686
14Chronic myeloid leukemia_Homo sapiens_hsa052201.22873602
15Non-small cell lung cancer_Homo sapiens_hsa052231.21558569
16Prostate cancer_Homo sapiens_hsa052151.21135645
17Type II diabetes mellitus_Homo sapiens_hsa049301.20647421
18Osteoclast differentiation_Homo sapiens_hsa043801.18696024
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18299318
20Long-term potentiation_Homo sapiens_hsa047201.13884017
21MicroRNAs in cancer_Homo sapiens_hsa052061.13690369
22Protein digestion and absorption_Homo sapiens_hsa049741.12763654
23Amoebiasis_Homo sapiens_hsa051461.12233448
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09166717
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08429353
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07044445
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.05556921
28Dilated cardiomyopathy_Homo sapiens_hsa054141.04797321
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04365436
30Leishmaniasis_Homo sapiens_hsa051401.02309271
31VEGF signaling pathway_Homo sapiens_hsa043701.01384142
32B cell receptor signaling pathway_Homo sapiens_hsa046620.99734597
33Basal cell carcinoma_Homo sapiens_hsa052170.99321028
34Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99133851
35NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99090202
36ABC transporters_Homo sapiens_hsa020100.98392775
37Vascular smooth muscle contraction_Homo sapiens_hsa042700.97988301
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97946689
39Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97587381
40T cell receptor signaling pathway_Homo sapiens_hsa046600.97533985
41Measles_Homo sapiens_hsa051620.96946172
42Leukocyte transendothelial migration_Homo sapiens_hsa046700.95747738
43Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95284170
44Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95275809
45Prolactin signaling pathway_Homo sapiens_hsa049170.94109522
46Notch signaling pathway_Homo sapiens_hsa043300.93222286
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92912469
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92447142
49TGF-beta signaling pathway_Homo sapiens_hsa043500.92393112
50Viral myocarditis_Homo sapiens_hsa054160.91787644
51Thyroid cancer_Homo sapiens_hsa052160.91438276
52Pancreatic cancer_Homo sapiens_hsa052120.89717499
53Rap1 signaling pathway_Homo sapiens_hsa040150.89427951
54Chemokine signaling pathway_Homo sapiens_hsa040620.89118517
55Insulin resistance_Homo sapiens_hsa049310.89014192
56Glioma_Homo sapiens_hsa052140.88921379
57Colorectal cancer_Homo sapiens_hsa052100.88906353
58Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87866309
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87278056
60Acute myeloid leukemia_Homo sapiens_hsa052210.86459061
61Platelet activation_Homo sapiens_hsa046110.85751825
62Complement and coagulation cascades_Homo sapiens_hsa046100.85465958
63PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85267836
64Pathways in cancer_Homo sapiens_hsa052000.85088806
65Axon guidance_Homo sapiens_hsa043600.84769133
66Hematopoietic cell lineage_Homo sapiens_hsa046400.84628577
67Malaria_Homo sapiens_hsa051440.84616992
68MAPK signaling pathway_Homo sapiens_hsa040100.84294898
69Endometrial cancer_Homo sapiens_hsa052130.83794502
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83740255
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.83731944
72Fatty acid biosynthesis_Homo sapiens_hsa000610.83640652
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83462159
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83222790
75Allograft rejection_Homo sapiens_hsa053300.83157963
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83126391
77Melanoma_Homo sapiens_hsa052180.82436401
78ErbB signaling pathway_Homo sapiens_hsa040120.81792537
79Hepatitis B_Homo sapiens_hsa051610.81744504
80cAMP signaling pathway_Homo sapiens_hsa040240.81101078
81Wnt signaling pathway_Homo sapiens_hsa043100.81015746
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80134833
83Influenza A_Homo sapiens_hsa051640.79905343
84Intestinal immune network for IgA production_Homo sapiens_hsa046720.79202654
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.77440879
86FoxO signaling pathway_Homo sapiens_hsa040680.77364189
87Renin secretion_Homo sapiens_hsa049240.77338999
88Oxytocin signaling pathway_Homo sapiens_hsa049210.75467059
89Ovarian steroidogenesis_Homo sapiens_hsa049130.75348242
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75143531
91mTOR signaling pathway_Homo sapiens_hsa041500.73786582
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73670644
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73411705
94Hedgehog signaling pathway_Homo sapiens_hsa043400.73243929
95Hippo signaling pathway_Homo sapiens_hsa043900.72550731
96Hepatitis C_Homo sapiens_hsa051600.71284658
97African trypanosomiasis_Homo sapiens_hsa051430.70950095
98Graft-versus-host disease_Homo sapiens_hsa053320.70684330
99Estrogen signaling pathway_Homo sapiens_hsa049150.70469307
100Calcium signaling pathway_Homo sapiens_hsa040200.70333912
101Choline metabolism in cancer_Homo sapiens_hsa052310.69765573
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.69194797
103GnRH signaling pathway_Homo sapiens_hsa049120.68968690
104Insulin secretion_Homo sapiens_hsa049110.68462484
105Glutamatergic synapse_Homo sapiens_hsa047240.68101932
106Thyroid hormone synthesis_Homo sapiens_hsa049180.67438229
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67406269
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67238204
109Inositol phosphate metabolism_Homo sapiens_hsa005620.67213501
110Melanogenesis_Homo sapiens_hsa049160.66927740
111Autoimmune thyroid disease_Homo sapiens_hsa053200.66519990
112HTLV-I infection_Homo sapiens_hsa051660.66485996
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66318161
114Ras signaling pathway_Homo sapiens_hsa040140.66290363
115Gap junction_Homo sapiens_hsa045400.65867837
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.65856403
117Long-term depression_Homo sapiens_hsa047300.65832864
118Primary immunodeficiency_Homo sapiens_hsa053400.65247191
119Renal cell carcinoma_Homo sapiens_hsa052110.65092087
120Tuberculosis_Homo sapiens_hsa051520.64456860
121Gastric acid secretion_Homo sapiens_hsa049710.64220432
122Cholinergic synapse_Homo sapiens_hsa047250.63760446
123Salivary secretion_Homo sapiens_hsa049700.62642359
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59357733
125Insulin signaling pathway_Homo sapiens_hsa049100.58570966
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58148060

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »