NFATC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.39574229
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.67828676
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.67828676
4positive thymic T cell selection (GO:0045059)5.44581066
5antigen processing and presentation of endogenous antigen (GO:0019883)5.44026699
6regulation of gamma-delta T cell differentiation (GO:0045586)5.27679488
7negative T cell selection (GO:0043383)5.14749086
8negative thymic T cell selection (GO:0045060)5.14438026
9regulation of B cell receptor signaling pathway (GO:0050855)5.06741390
10leukocyte aggregation (GO:0070486)4.97018375
11regulation of gamma-delta T cell activation (GO:0046643)4.89972318
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.85742990
13regulation of interleukin-12 biosynthetic process (GO:0045075)4.83628209
14response to interleukin-15 (GO:0070672)4.68464086
15thymic T cell selection (GO:0045061)4.60460275
16positive T cell selection (GO:0043368)4.52223594
17tolerance induction (GO:0002507)4.52025217
18interferon-gamma production (GO:0032609)4.36728607
19positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.36630337
20cellular response to interleukin-15 (GO:0071350)4.33696751
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.33196787
22negative regulation of cell killing (GO:0031342)4.29619373
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.29619373
24T cell selection (GO:0045058)4.21458353
25regulation of B cell differentiation (GO:0045577)4.08889710
26negative regulation of erythrocyte differentiation (GO:0045647)3.99760796
27B cell receptor signaling pathway (GO:0050853)3.96381173
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.91558023
29T cell migration (GO:0072678)3.82960424
30regulation of T-helper 1 cell differentiation (GO:0045625)3.73134904
31regulation of isotype switching to IgG isotypes (GO:0048302)3.69367257
32regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.67673059
33regulation of T cell tolerance induction (GO:0002664)3.64906672
34positive regulation of B cell differentiation (GO:0045579)3.63496058
35neutrophil activation involved in immune response (GO:0002283)3.60053250
36positive regulation by organism of defense response of other organism involved in symbiotic interact3.59437038
37modulation by symbiont of host immune response (GO:0052553)3.59437038
38positive regulation by symbiont of host defense response (GO:0052509)3.59437038
39modulation by symbiont of host defense response (GO:0052031)3.59437038
40modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59437038
41modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59437038
42regulation of alpha-beta T cell proliferation (GO:0046640)3.57802933
43negative regulation of T-helper cell differentiation (GO:0045623)3.56968697
44negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.56968697
45T cell costimulation (GO:0031295)3.53252532
46Peyers patch development (GO:0048541)3.52910825
47mucosal-associated lymphoid tissue development (GO:0048537)3.52910825
48antigen receptor-mediated signaling pathway (GO:0050851)3.50929693
49lymphocyte costimulation (GO:0031294)3.48027602
50positive regulation of isotype switching (GO:0045830)3.45288037
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43770598
52macrophage activation involved in immune response (GO:0002281)3.43588916
53T cell receptor signaling pathway (GO:0050852)3.42990057
54regulation of T-helper 2 cell differentiation (GO:0045628)3.40665532
55regulation of dendritic cell antigen processing and presentation (GO:0002604)3.35560145
56myeloid dendritic cell activation (GO:0001773)3.33710054
57positive regulation of interleukin-2 production (GO:0032743)3.31350166
58regulation of T cell receptor signaling pathway (GO:0050856)3.29116200
59regulation of interleukin-2 biosynthetic process (GO:0045076)3.29021289
60response to peptidoglycan (GO:0032494)3.27912652
61detection of bacterium (GO:0016045)3.24101802
62positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.23302552
63detection of other organism (GO:0098543)3.20652121
64leukocyte cell-cell adhesion (GO:0007159)3.20596624
65positive regulation of natural killer cell differentiation (GO:0032825)3.19727553
66activated T cell proliferation (GO:0050798)3.18506371
67JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.18295485
68positive regulation of granulocyte differentiation (GO:0030854)3.17354382
69regulation of regulatory T cell differentiation (GO:0045589)3.17048973
70positive regulation of alpha-beta T cell proliferation (GO:0046641)3.14826673
71NIK/NF-kappaB signaling (GO:0038061)3.13579771
72myeloid dendritic cell differentiation (GO:0043011)3.12713702
73negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.09565989
74regulation of antigen processing and presentation (GO:0002577)3.09046689
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.07756940
76negative regulation of interleukin-12 production (GO:0032695)3.06716665
77mature B cell differentiation (GO:0002335)3.05259316
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.04128821
79interferon-gamma-mediated signaling pathway (GO:0060333)3.02870754
80positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.01346410
81B cell mediated immunity (GO:0019724)3.01232303
82positive regulation of DNA recombination (GO:0045911)3.00144118
83positive regulation of tolerance induction (GO:0002645)2.99290645
84regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.98780436
85positive regulation of B cell mediated immunity (GO:0002714)2.98553739
86positive regulation of immunoglobulin mediated immune response (GO:0002891)2.98553739
87T cell homeostasis (GO:0043029)2.98246606
88regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94789618
89lymphocyte homeostasis (GO:0002260)2.91549822
90response to protozoan (GO:0001562)2.91430031
91lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91126122
92regulation of isotype switching (GO:0045191)2.89933612
93response to muramyl dipeptide (GO:0032495)2.89562735
94positive regulation of antigen processing and presentation (GO:0002579)2.88012930
95myeloid cell activation involved in immune response (GO:0002275)2.87954174
96regulation of response to interferon-gamma (GO:0060330)2.87508417
97T cell proliferation (GO:0042098)2.87298760
98regulation of B cell proliferation (GO:0030888)2.85749293
99regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.85721414
100regulation of interferon-beta biosynthetic process (GO:0045357)2.85480535
101response to type I interferon (GO:0034340)2.85078375
102positive regulation of type 2 immune response (GO:0002830)2.84762256
103positive regulation of alpha-beta T cell differentiation (GO:0046638)2.83364308
104negative regulation of alpha-beta T cell activation (GO:0046636)2.81730155
105mast cell activation (GO:0045576)2.81411562
106regulation of B cell mediated immunity (GO:0002712)2.81115080
107negative regulation of bone resorption (GO:0045779)2.81016345
108positive regulation of immunoglobulin production (GO:0002639)2.80189947
109regulation of tolerance induction (GO:0002643)2.80056764
110positive regulation of B cell activation (GO:0050871)2.79799599
111regulation of alpha-beta T cell differentiation (GO:0046637)2.79656941
112negative regulation of leukocyte mediated immunity (GO:0002704)2.79546288
113CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.79383394
114negative regulation of phagocytosis (GO:0050765)2.78940092
115positive regulation of T cell differentiation (GO:0045582)2.78749974
116regulation of immunoglobulin mediated immune response (GO:0002889)2.78199473
117type I interferon signaling pathway (GO:0060337)2.78093841
118cellular response to type I interferon (GO:0071357)2.78093841
119lymph node development (GO:0048535)2.77680532
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.77121618
121Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76721871
122regulation of granulocyte differentiation (GO:0030852)2.76590708
123positive regulation of B cell proliferation (GO:0030890)2.76352515
124natural killer cell activation (GO:0030101)2.76276317
125negative regulation of T cell receptor signaling pathway (GO:0050860)2.76230789
126immunoglobulin mediated immune response (GO:0016064)2.75592713
127regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.75282505
128regulation of natural killer cell mediated immunity (GO:0002715)2.75282505
129germinal center formation (GO:0002467)2.74142224
130positive regulation of humoral immune response (GO:0002922)2.73927687
131defense response to protozoan (GO:0042832)2.73876788
132negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.72462251
133immune response-activating cell surface receptor signaling pathway (GO:0002429)2.71068250
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70741623
135cellular extravasation (GO:0045123)2.70079860
136negative regulation of T cell mediated immunity (GO:0002710)2.67917194
137B cell homeostasis (GO:0001782)2.66086192
138regulation of interleukin-2 production (GO:0032663)2.65812877
139regulation of B cell activation (GO:0050864)2.64661123
140regulation of extracellular matrix disassembly (GO:0010715)2.63786448

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.43615194
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.34118151
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.71315162
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.44967048
5* MYC_22102868_ChIP-Seq_BL_Human3.35506545
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.35442667
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.19750490
8RUNX_20019798_ChIP-Seq_JUKART_Human3.19677041
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.14926755
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.97233821
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.93184768
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.87957073
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.85364208
14MYB_26560356_Chip-Seq_TH2_Human2.84510828
15* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83291871
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73029045
17MAF_26560356_Chip-Seq_TH1_Human2.67490073
18SCL_19346495_ChIP-Seq_HPC-7_Human2.59733373
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58578826
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57511626
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.56487837
22* MYB_26560356_Chip-Seq_TH1_Human2.46403675
23* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.46187362
24* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45118504
25* VDR_21846776_ChIP-Seq_THP-1_Human2.45040578
26NOTCH1_21737748_ChIP-Seq_TLL_Human2.34658546
27E2F7_22180533_ChIP-Seq_HELA_Human2.30757347
28* UTX_26944678_Chip-Seq_JUKART_Human2.17788333
29VDR_24763502_ChIP-Seq_THP-1_Human2.11574562
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10107942
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04195701
32* TCF7_22412390_ChIP-Seq_EML_Mouse2.02835086
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.98864321
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97752739
35* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94312574
36SPI1_23547873_ChIP-Seq_NB4_Human1.94155679
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93960948
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.79777857
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.77434641
40* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.76832776
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.76078085
42GATA3_27048872_Chip-Seq_THYMUS_Human1.73001804
43MAF_26560356_Chip-Seq_TH2_Human1.69154576
44* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67642715
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.64646987
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54906506
47SPI1_23127762_ChIP-Seq_K562_Human1.54792827
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54376608
49* KDM2B_26808549_Chip-Seq_DND41_Human1.50649214
50GATA1_22025678_ChIP-Seq_K562_Human1.50014921
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49941722
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.47045343
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.44603443
54* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42702613
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.42450347
56PU_27001747_Chip-Seq_BMDM_Mouse1.40799660
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37921126
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37837560
59GATA1_19941826_ChIP-Seq_K562_Human1.32536250
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29831716
61* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26219335
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.20113896
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19066030
64CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18843356
65Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16171379
66BCL6_27268052_Chip-Seq_Bcells_Human1.15157549
67* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13112035
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12633781
69GATA3_26560356_Chip-Seq_TH2_Human1.11838577
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11506165
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10436445
72BCOR_27268052_Chip-Seq_Bcells_Human1.09976964
73VDR_24787735_ChIP-Seq_THP-1_Human1.09367010
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09348907
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.08006727
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06641423
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04542960
78* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.99600954
79VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.98456081
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96862345
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96691194
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.96184084
83* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93869231
84* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93724612
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93164131
86P68_20966046_ChIP-Seq_HELA_Human0.92957325
87* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92842609
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92811597
89SA1_27219007_Chip-Seq_ERYTHROID_Human0.92607284
90* KDM2B_26808549_Chip-Seq_JURKAT_Human0.92134304
91CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91004713
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88646604
93RACK7_27058665_Chip-Seq_MCF-7_Human0.88572025
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88568120
95* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88249070
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87951335
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87951322
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87916694
99CIITA_25753668_ChIP-Seq_RAJI_Human0.86972864
100CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85679268
101NCOR1_26117541_ChIP-Seq_K562_Human0.85655014
102* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85555605
103* CTCF_26484167_Chip-Seq_Bcells_Mouse0.84000309
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83570861
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83112934
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83086715
107* GATA1_19941827_ChIP-Seq_MEL_Mouse0.82428437
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82359524
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.81694907
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81393968
111* GATA2_19941826_ChIP-Seq_K562_Human0.79641174
112ERG_20887958_ChIP-Seq_HPC-7_Mouse0.78491302
113SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.76791022
114SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75383571
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75383571
116* LXR_22292898_ChIP-Seq_THP-1_Human0.75303451
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.73833331
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.73673717
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.73635355

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.81987354
2MP0003763_abnormal_thymus_physiology3.70864171
3MP0005671_abnormal_response_to3.50380955
4MP0000685_abnormal_immune_system3.40995804
5MP0003436_decreased_susceptibility_to3.25237201
6* MP0001800_abnormal_humoral_immune3.18574924
7* MP0001790_abnormal_immune_system3.10584054
8* MP0005387_immune_system_phenotype3.10584054
9MP0002933_joint_inflammation3.01219750
10MP0003303_peritoneal_inflammation2.92438921
11MP0005000_abnormal_immune_tolerance2.90958558
12* MP0002452_abnormal_antigen_presenting2.70296410
13* MP0002723_abnormal_immune_serum2.59780741
14MP0003300_gastrointestinal_ulcer2.59618685
15* MP0002420_abnormal_adaptive_immunity2.55161340
16* MP0001819_abnormal_immune_cell2.50882880
17MP0009785_altered_susceptibility_to2.45306202
18* MP0002398_abnormal_bone_marrow2.36393121
19MP0002396_abnormal_hematopoietic_system2.33177434
20MP0005025_abnormal_response_to2.31856630
21MP0002166_altered_tumor_susceptibility2.31213152
22* MP0002405_respiratory_system_inflammati2.26522877
23MP0002419_abnormal_innate_immunity2.15512835
24* MP0000716_abnormal_immune_system2.13202410
25MP0002148_abnormal_hypersensitivity_rea2.11770412
26MP0003724_increased_susceptibility_to2.09937176
27MP0009333_abnormal_splenocyte_physiolog2.04756202
28MP0010155_abnormal_intestine_physiology2.00539317
29MP0000689_abnormal_spleen_morphology1.98736021
30MP0001533_abnormal_skeleton_physiology1.96964301
31MP0006082_CNS_inflammation1.95001688
32MP0002722_abnormal_immune_system1.92397453
33MP0001853_heart_inflammation1.91276393
34MP0005451_abnormal_body_composition1.86235763
35MP0004947_skin_inflammation1.85707116
36MP0000703_abnormal_thymus_morphology1.84417561
37MP0002006_tumorigenesis1.76434749
38* MP0002429_abnormal_blood_cell1.75481318
39MP0005464_abnormal_platelet_physiology1.73604649
40MP0004510_myositis1.69242705
41MP0003172_abnormal_lysosome_physiology1.69037742
42* MP0001845_abnormal_inflammatory_respons1.68845078
43MP0004808_abnormal_hematopoietic_stem1.62558964
44* MP0001873_stomach_inflammation1.57892460
45MP0005058_abnormal_lysosome_morphology1.52876589
46MP0003866_abnormal_defecation1.52862578
47MP0001851_eye_inflammation1.30471512
48MP0005390_skeleton_phenotype1.27281913
49MP0002998_abnormal_bone_remodeling1.26783112
50MP0000858_altered_metastatic_potential1.19420723
51MP0003448_altered_tumor_morphology1.19102736
52MP0001545_abnormal_hematopoietic_system1.17583346
53MP0005397_hematopoietic_system_phenotyp1.17583346
54MP0009840_abnormal_foam_cell1.17386169
55MP0010352_gastrointestinal_tract_polyps1.15468259
56MP0008469_abnormal_protein_level1.15169243
57MP0000343_altered_response_to1.14925034
58MP0005023_abnormal_wound_healing1.12733991
59MP0003566_abnormal_cell_adhesion1.12675047
60MP0000490_abnormal_crypts_of1.11426185
61* MP0000465_gastrointestinal_hemorrhage1.10093634
62MP0005076_abnormal_cell_differentiation1.09799034
63MP0009278_abnormal_bone_marrow1.09445108
64* MP0003795_abnormal_bone_structure1.09362986
65MP0008004_abnormal_stomach_pH1.05898107
66MP0005167_abnormal_blood-brain_barrier1.05384243
67MP0008260_abnormal_autophagy1.04581515
68MP0003183_abnormal_peptide_metabolism1.04132540
69MP0003075_altered_response_to1.03621497
70MP0002254_reproductive_system_inflammat1.01595588
71MP0004134_abnormal_chest_morphology1.01593109
72MP0003279_aneurysm0.96659730
73MP0002138_abnormal_hepatobiliary_system0.93777836
74MP0006054_spinal_hemorrhage0.90975101
75MP0005310_abnormal_salivary_gland0.87587484
76MP0003656_abnormal_erythrocyte_physiolo0.87250996
77MP0002332_abnormal_exercise_endurance0.86502607
78MP0003045_fibrosis0.83609432
79MP0002019_abnormal_tumor_incidence0.82975791
80MP0003091_abnormal_cell_migration0.78210714
81* MP0002113_abnormal_skeleton_development0.77865116
82MP0001243_abnormal_dermal_layer0.74404264
83MP0001348_abnormal_lacrimal_gland0.74186598
84MP0003828_pulmonary_edema0.74181146
85MP0001216_abnormal_epidermal_layer0.73378428
86MP0005174_abnormal_tail_pigmentation0.72294024
87MP0009764_decreased_sensitivity_to0.71570028
88* MP0001663_abnormal_digestive_system0.70279780
89MP0000249_abnormal_blood_vessel0.70023557
90MP0000604_amyloidosis0.69709441
91MP0002282_abnormal_trachea_morphology0.69098231
92MP0001542_abnormal_bone_strength0.66899684
93MP0002877_abnormal_melanocyte_morpholog0.66829903
94MP0003646_muscle_fatigue0.66637183
95MP0002009_preneoplasia0.65672878
96* MP0002115_abnormal_skeleton_extremities0.65430077
97MP0004381_abnormal_hair_follicle0.64586154
98MP0009763_increased_sensitivity_to0.64193393
99MP0002060_abnormal_skin_morphology0.64044462
100MP0001879_abnormal_lymphatic_vessel0.63031442
101MP0003453_abnormal_keratinocyte_physiol0.61377963
102MP0008961_abnormal_basal_metabolism0.61311021
103MP0002136_abnormal_kidney_physiology0.60997134
104MP0005166_decreased_susceptibility_to0.60041797
105MP0008007_abnormal_cellular_replicative0.59193031
106MP0004036_abnormal_muscle_relaxation0.58785653
107MP0005666_abnormal_adipose_tissue0.58343446
108* MP0000163_abnormal_cartilage_morphology0.57360710
109MP0001191_abnormal_skin_condition0.57173788
110MP0000767_abnormal_smooth_muscle0.57162426
111MP0005075_abnormal_melanosome_morpholog0.56591920
112MP0009765_abnormal_xenobiotic_induced0.56540691
113MP0004130_abnormal_muscle_cell0.56138932
114MP0008057_abnormal_DNA_replication0.55614522
115MP0004883_abnormal_blood_vessel0.53768992
116MP0008874_decreased_physiological_sensi0.52189562
117MP0003705_abnormal_hypodermis_morpholog0.50476607
118MP0003191_abnormal_cellular_cholesterol0.50328480
119MP0005503_abnormal_tendon_morphology0.50090754
120MP0002132_abnormal_respiratory_system0.49866891
121* MP0005381_digestive/alimentary_phenotyp0.47489081
122MP0009115_abnormal_fat_cell0.47134800
123MP0002277_abnormal_respiratory_mucosa0.46364986

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)5.27381699
2Irregular epiphyses (HP:0010582)4.46272589
3Small epiphyses (HP:0010585)4.26899782
4Recurrent bronchitis (HP:0002837)3.78796952
5IgM deficiency (HP:0002850)3.78239707
6Abnormality of macrophages (HP:0004311)3.75032276
7Eczematoid dermatitis (HP:0000976)3.72819243
8T lymphocytopenia (HP:0005403)3.52063157
9Abnormal tarsal ossification (HP:0008369)3.49135679
10Elevated erythrocyte sedimentation rate (HP:0003565)3.44583240
11Myositis (HP:0100614)3.43111751
12Abnormality of T cell number (HP:0011839)3.39975373
13Recurrent fungal infections (HP:0002841)3.32643397
14Recurrent viral infections (HP:0004429)3.30103985
15Vitreoretinal degeneration (HP:0000655)3.25607500
16Increased IgM level (HP:0003496)3.22896693
17Prolonged bleeding time (HP:0003010)3.20531407
18Metaphyseal cupping (HP:0003021)3.20066475
19Panhypogammaglobulinemia (HP:0003139)3.19944776
20Chronic otitis media (HP:0000389)3.17296888
21Recurrent abscess formation (HP:0002722)3.17106728
22Abnormal foot bone ossification (HP:0010675)3.15801074
23Stomatitis (HP:0010280)3.14823631
24Nasal polyposis (HP:0100582)3.13948184
25Metaphyseal dysplasia (HP:0100255)3.09777788
26Agammaglobulinemia (HP:0004432)3.08425236
27Abnormality of T cells (HP:0002843)3.03446664
28Encephalitis (HP:0002383)3.02872730
29Cupped ribs (HP:0000887)3.02063542
30Autoimmune hemolytic anemia (HP:0001890)2.98274336
31Abnormality of B cell number (HP:0010975)2.90942532
32B lymphocytopenia (HP:0010976)2.90942532
33Hypoplastic ischia (HP:0003175)2.89327066
34Abnormality of the vertebral endplates (HP:0005106)2.85591839
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.83369579
36Meningitis (HP:0001287)2.80080365
37Irregular vertebral endplates (HP:0003301)2.79827574
38Abnormality of the nasal mucosa (HP:0000433)2.79487085
39Abnormality of the fingertips (HP:0001211)2.79116753
40Flat acetabular roof (HP:0003180)2.79096906
41Recurrent gram-negative bacterial infections (HP:0005420)2.76010271
42Gastrointestinal infarctions (HP:0005244)2.75346071
43Flattened epiphyses (HP:0003071)2.75063673
44Severe combined immunodeficiency (HP:0004430)2.71547384
45Inflammation of the large intestine (HP:0002037)2.69516187
46Epistaxis (HP:0000421)2.67927528
47Orchitis (HP:0100796)2.65027231
48Delayed epiphyseal ossification (HP:0002663)2.63844198
49Hemoptysis (HP:0002105)2.63289377
50Recurrent bacterial skin infections (HP:0005406)2.62905921
51Vasculitis (HP:0002633)2.62813577
52Genu varum (HP:0002970)2.62300068
53Retrobulbar optic neuritis (HP:0100654)2.62194455
54Optic neuritis (HP:0100653)2.62194455
55Gastrointestinal inflammation (HP:0004386)2.61228433
56Flat capital femoral epiphysis (HP:0003370)2.60978403
57Increased IgE level (HP:0003212)2.58968747
58Cellulitis (HP:0100658)2.58608086
59Lymphopenia (HP:0001888)2.57730860
60Abnormality of T cell physiology (HP:0011840)2.57633321
61Petechiae (HP:0000967)2.56686342
62Mild short stature (HP:0003502)2.55375042
63Chest pain (HP:0100749)2.55371085
64Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.54964852
65Abnormality of femoral epiphyses (HP:0006499)2.54964852
66Recurrent cutaneous fungal infections (HP:0011370)2.54643501
67Chronic mucocutaneous candidiasis (HP:0002728)2.54643501
68Restrictive lung disease (HP:0002091)2.54603648
69Abnormality of liposaccharide metabolism (HP:0010968)2.53142857
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.53142857
71Abnormality of glycolipid metabolism (HP:0010969)2.53142857
72Abnormality of the ischium (HP:0003174)2.50381233
73Gastrointestinal stroma tumor (HP:0100723)2.50108693
74Increased cerebral lipofuscin (HP:0011813)2.48991044
75Mediastinal lymphadenopathy (HP:0100721)2.48139378
76Abnormality of cells of the lymphoid lineage (HP:0012140)2.48094496
77Keratoconjunctivitis sicca (HP:0001097)2.47879057
78IgG deficiency (HP:0004315)2.47419877
79Combined immunodeficiency (HP:0005387)2.47126000
80Loss of speech (HP:0002371)2.44773942
81Fatigue (HP:0012378)2.44216462
82Spontaneous hematomas (HP:0007420)2.43127960
83Granulocytopenia (HP:0001913)2.41348303
84Colitis (HP:0002583)2.40908595
85Osteomyelitis (HP:0002754)2.40190224
86Pustule (HP:0200039)2.38143471
87Enlarged epiphyses (HP:0010580)2.37154507
88Recurrent sinusitis (HP:0011108)2.36843110
89Abnormality of the epiphysis of the femoral head (HP:0010574)2.36324556
90Exercise-induced myalgia (HP:0003738)2.36281018
91Gingivitis (HP:0000230)2.35670365
92Dysostosis multiplex (HP:0000943)2.34408211
93Absent frontal sinuses (HP:0002688)2.33787884
94Thrombocytosis (HP:0001894)2.33048900
95Pulmonary infiltrates (HP:0002113)2.31828607
96Keratoconjunctivitis (HP:0001096)2.29885837
97Obstructive lung disease (HP:0006536)2.29706129
98Chronic obstructive pulmonary disease (HP:0006510)2.29706129
99Short femoral neck (HP:0100864)2.29401825
100Chronic diarrhea (HP:0002028)2.28826766
101Purpura (HP:0000979)2.28767007
102Asymmetric septal hypertrophy (HP:0001670)2.28285733
103Hypergammaglobulinemia (HP:0010702)2.26324050
104Thyroiditis (HP:0100646)2.25471419
105IgA deficiency (HP:0002720)2.24823363
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.24217834
107Arterial thrombosis (HP:0004420)2.23764022
108Increased neuronal autofluorescent lipopigment (HP:0002074)2.22954344
109Increased serum ferritin (HP:0003281)2.22382034
110Arthropathy (HP:0003040)2.20530087
111Urticaria (HP:0001025)2.19905593
112Recurrent skin infections (HP:0001581)2.19713093
113Abnormality of the femoral head (HP:0003368)2.18283789
114Emphysema (HP:0002097)2.17967012
115Limited elbow extension (HP:0001377)2.16989539
116Centrally nucleated skeletal muscle fibers (HP:0003687)2.16480499
117Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.15929795
118Absent epiphyses (HP:0010577)2.15929795
119Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.15074705
120Increased density of long bones (HP:0006392)2.13362015
121Verrucae (HP:0200043)2.13132370
122Papilloma (HP:0012740)2.13132370
123Joint swelling (HP:0001386)2.12709608
124Coxa vara (HP:0002812)2.11875976
125Arthralgia (HP:0002829)2.09464317
126Eosinophilia (HP:0001880)2.05854727
127Hematochezia (HP:0002573)2.05577701
128Autoimmune thrombocytopenia (HP:0001973)2.05374538
129Hypertensive crisis (HP:0100735)2.02963999
130Chronic sinusitis (HP:0011109)2.02478766
131Abnormality of eosinophils (HP:0001879)2.02389642
132Persistence of primary teeth (HP:0006335)2.02152774
133Metaphyseal irregularity (HP:0003025)2.01819809
134Bronchitis (HP:0012387)2.01796666
135Nemaline bodies (HP:0003798)2.01763630
136Leukocytosis (HP:0001974)2.01414915
137Sepsis (HP:0100806)2.01044972
138Hepatosplenomegaly (HP:0001433)2.00395350
139Muscle fiber inclusion bodies (HP:0100299)2.00109985
140Abnormality of the prostate (HP:0008775)1.95954423
141Lymphoma (HP:0002665)1.92663866

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.43705398
2TXK4.00757433
3PRPF4B2.94148804
4JAK32.80246832
5ZAP702.54744804
6STK102.50721582
7MAP3K142.44759521
8ITK2.42583614
9TYK22.34033970
10BTK2.01074613
11EEF2K1.99728746
12TEC1.98609524
13TBK11.94479041
14JAK11.92889358
15IKBKE1.88397720
16ERN11.87748496
17TGFBR21.80636196
18FGFR41.72209684
19IKBKB1.67996429
20STK241.65438692
21CSK1.64912847
22FGFR31.60584562
23KIT1.60339045
24IRAK31.60194111
25IRAK41.59859190
26MAP3K31.58165265
27TAOK21.58040623
28GRK61.55777482
29CSF1R1.55735897
30SYK1.54854432
31MAP3K101.54296191
32LCK1.53896106
33HCK1.53645592
34NLK1.52854993
35BLK1.51307543
36MST41.49808551
37LRRK21.38968871
38MAP2K31.37378585
39CHUK1.27942147
40SMG11.25539266
41PIM11.22464332
42TRIB31.21641697
43PIM21.20424067
44EPHB11.20155161
45KDR1.17178485
46RPS6KA41.14904716
47CLK11.09993209
48MAP3K11.08779795
49NME21.07887651
50CDK121.07731151
51LYN1.00827687
52PKN21.00466231
53MARK30.95766291
54SIK30.94197592
55FES0.92837736
56TRPM70.92820487
57SIK20.90853280
58CDC42BPA0.88903392
59MARK20.88749806
60PRKCQ0.87414654
61MAP3K130.86062626
62TGFBR10.86001702
63BMPR20.82468002
64MATK0.82043102
65EPHA30.80496543
66FGR0.79605284
67PIK3CG0.78381045
68OBSCN0.75876185
69FLT30.75644346
70JAK20.75434610
71TTN0.74329043
72TAOK10.73610783
73PRKCH0.73278789
74IRAK20.72237741
75TAOK30.70691744
76SIK10.68795023
77PTK60.67645130
78CDK90.63414114
79RPS6KL10.62058747
80RPS6KC10.62058747
81MAP3K70.60800040
82PRKG20.59832232
83NEK90.59174462
84RIPK40.57259467
85TNK20.55555347
86RPS6KA60.55381902
87CDK40.55336347
88HIPK20.53541126
89MOS0.53159155
90KSR20.52749367
91CCNB10.52440462
92ICK0.51752786
93BRD40.51682482
94RIPK10.51636248
95CDK60.50492320
96MAPK70.49120735
97MAPK120.48810445
98PDGFRB0.48216434
99NUAK10.47906186
100MAP2K20.47534023
101DMPK0.45693400
102ABL10.45644744
103MAPK40.44335507
104TIE10.43809589
105MAPKAPK20.42809477
106MAP3K110.42062853
107GRK70.41555405
108PDPK10.41553757
109MAP2K60.40656638
110PDK10.39510352
111MELK0.38503457
112TESK20.36826354
113SGK30.36756017
114STK30.36205430
115TYRO30.36155741
116EGFR0.34311881
117IGF1R0.33561858
118EIF2AK30.32923100
119INSR0.32850196
120STK40.32544769
121CAMKK10.32148912
122MAPK110.30514141
123PASK0.30395638
124MAPKAPK30.30330137
125MAP3K80.30032176
126PRKD20.28432378
127RPS6KB20.28337987
128* MAPK30.26936365
129IRAK10.25930046
130TSSK60.25889357

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.38252304
2* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.79921421
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.74258679
4* T cell receptor signaling pathway_Homo sapiens_hsa046602.66187632
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.62295077
6* B cell receptor signaling pathway_Homo sapiens_hsa046622.56145187
7Leishmaniasis_Homo sapiens_hsa051402.52093349
8Measles_Homo sapiens_hsa051622.45988839
9Hematopoietic cell lineage_Homo sapiens_hsa046402.28835480
10* Osteoclast differentiation_Homo sapiens_hsa043802.25416025
11* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.17633015
12Allograft rejection_Homo sapiens_hsa053302.17163220
13Antigen processing and presentation_Homo sapiens_hsa046122.14896973
14Graft-versus-host disease_Homo sapiens_hsa053321.84896612
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.82403843
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81949392
17Malaria_Homo sapiens_hsa051441.75183723
18Viral myocarditis_Homo sapiens_hsa054161.64998805
19Toxoplasmosis_Homo sapiens_hsa051451.61859722
20Autoimmune thyroid disease_Homo sapiens_hsa053201.60770167
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55070103
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52146752
23Herpes simplex infection_Homo sapiens_hsa051681.50181869
24Legionellosis_Homo sapiens_hsa051341.46883026
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44191968
26Acute myeloid leukemia_Homo sapiens_hsa052211.41799856
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40790263
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.39535484
29TNF signaling pathway_Homo sapiens_hsa046681.38047887
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35793987
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34527316
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33677375
33Staphylococcus aureus infection_Homo sapiens_hsa051501.30540153
34* Hepatitis B_Homo sapiens_hsa051611.30506046
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29172212
36Chemokine signaling pathway_Homo sapiens_hsa040621.28949808
37Asthma_Homo sapiens_hsa053101.28291531
38Shigellosis_Homo sapiens_hsa051311.28071773
39Apoptosis_Homo sapiens_hsa042101.27090039
40Chronic myeloid leukemia_Homo sapiens_hsa052201.25096629
41Influenza A_Homo sapiens_hsa051641.23713559
42Tuberculosis_Homo sapiens_hsa051521.19346494
43Pertussis_Homo sapiens_hsa051331.14140352
44Platelet activation_Homo sapiens_hsa046111.11492861
45Pancreatic cancer_Homo sapiens_hsa052121.06250451
46* HTLV-I infection_Homo sapiens_hsa051661.03264050
47* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02856944
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00221426
49Other glycan degradation_Homo sapiens_hsa005110.99546698
50Epstein-Barr virus infection_Homo sapiens_hsa051690.95602833
51ECM-receptor interaction_Homo sapiens_hsa045120.89529088
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.87956436
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.87349723
54Salmonella infection_Homo sapiens_hsa051320.86297871
55Ribosome_Homo sapiens_hsa030100.84367864
56Hepatitis C_Homo sapiens_hsa051600.83505119
57Small cell lung cancer_Homo sapiens_hsa052220.82910825
58Viral carcinogenesis_Homo sapiens_hsa052030.80148596
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78540220
60Prolactin signaling pathway_Homo sapiens_hsa049170.77471619
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73547921
62Phagosome_Homo sapiens_hsa041450.72696286
63Focal adhesion_Homo sapiens_hsa045100.66619098
64Protein digestion and absorption_Homo sapiens_hsa049740.65838862
65VEGF signaling pathway_Homo sapiens_hsa043700.65820676
66Type I diabetes mellitus_Homo sapiens_hsa049400.65032761
67Colorectal cancer_Homo sapiens_hsa052100.64250717
68Proteoglycans in cancer_Homo sapiens_hsa052050.60956056
69Notch signaling pathway_Homo sapiens_hsa043300.60352002
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56025862
71Insulin resistance_Homo sapiens_hsa049310.55515272
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55433602
73MicroRNAs in cancer_Homo sapiens_hsa052060.54045853
74p53 signaling pathway_Homo sapiens_hsa041150.53955700
75mTOR signaling pathway_Homo sapiens_hsa041500.53900577
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52651815
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50666137
78Non-small cell lung cancer_Homo sapiens_hsa052230.50539811
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48002136
80Rheumatoid arthritis_Homo sapiens_hsa053230.47744129
81Adherens junction_Homo sapiens_hsa045200.47682636
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.47600380
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44420163
84FoxO signaling pathway_Homo sapiens_hsa040680.43957677
85Bladder cancer_Homo sapiens_hsa052190.43837852
86Prostate cancer_Homo sapiens_hsa052150.43578994
87PI3K-Akt signaling pathway_Homo sapiens_hsa041510.43282807
88Base excision repair_Homo sapiens_hsa034100.41910378
89Non-homologous end-joining_Homo sapiens_hsa034500.41839761
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.41778804
91Prion diseases_Homo sapiens_hsa050200.41636776
92Systemic lupus erythematosus_Homo sapiens_hsa053220.41312675
93HIF-1 signaling pathway_Homo sapiens_hsa040660.40816275
94African trypanosomiasis_Homo sapiens_hsa051430.40388552
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.39665906
96Insulin signaling pathway_Homo sapiens_hsa049100.39265703
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38419922
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38088492
99Amoebiasis_Homo sapiens_hsa051460.37444168
100Pathways in cancer_Homo sapiens_hsa052000.37258936
101Endocytosis_Homo sapiens_hsa041440.36641149
102GnRH signaling pathway_Homo sapiens_hsa049120.36569366
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.36545575
104Endometrial cancer_Homo sapiens_hsa052130.36360277
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35156953
106TGF-beta signaling pathway_Homo sapiens_hsa043500.35002395
107* MAPK signaling pathway_Homo sapiens_hsa040100.34996938
108Renal cell carcinoma_Homo sapiens_hsa052110.33696202
109Choline metabolism in cancer_Homo sapiens_hsa052310.33200628
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30360173
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29047394
112Lysine degradation_Homo sapiens_hsa003100.28765222
113Rap1 signaling pathway_Homo sapiens_hsa040150.28297498
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27114866
115Thyroid cancer_Homo sapiens_hsa052160.26521574
116Dorso-ventral axis formation_Homo sapiens_hsa043200.25151053
117Lysosome_Homo sapiens_hsa041420.25150150
118Inositol phosphate metabolism_Homo sapiens_hsa005620.24694270
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24249590
120Type II diabetes mellitus_Homo sapiens_hsa049300.22664087
121Caffeine metabolism_Homo sapiens_hsa002320.22326857
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21691392
123ErbB signaling pathway_Homo sapiens_hsa040120.20787823

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