NFATC2IP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.14294321
2protein localization to kinetochore (GO:0034501)4.96844348
3nuclear pore organization (GO:0006999)4.95898620
4nuclear pore complex assembly (GO:0051292)4.95003963
5translational termination (GO:0006415)4.83020242
6ribosomal small subunit biogenesis (GO:0042274)4.79363124
7DNA replication-dependent nucleosome organization (GO:0034723)4.72449012
8DNA replication-dependent nucleosome assembly (GO:0006335)4.72449012
9mitotic sister chromatid segregation (GO:0000070)4.45844695
10protein localization to chromosome, centromeric region (GO:0071459)4.38370076
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.37090513
12regulation of gene silencing by RNA (GO:0060966)4.25867675
13regulation of posttranscriptional gene silencing (GO:0060147)4.25867675
14regulation of gene silencing by miRNA (GO:0060964)4.25867675
15DNA replication initiation (GO:0006270)4.24839780
16mitotic metaphase plate congression (GO:0007080)4.22673241
17positive regulation of gamma-delta T cell activation (GO:0046645)4.07258966
18sister chromatid segregation (GO:0000819)4.05810839
19regulation of histone H3-K9 methylation (GO:0051570)4.05750665
20DNA unwinding involved in DNA replication (GO:0006268)4.03949845
21mitotic nuclear envelope disassembly (GO:0007077)4.01873730
22DNA replication checkpoint (GO:0000076)4.00428699
23pore complex assembly (GO:0046931)3.99745728
24mitotic chromosome condensation (GO:0007076)3.98714580
25translational elongation (GO:0006414)3.97322471
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.94865493
27regulation of helicase activity (GO:0051095)3.88420844
28histone H4-K12 acetylation (GO:0043983)3.86415457
29heterochromatin organization (GO:0070828)3.85295491
30DNA strand elongation involved in DNA replication (GO:0006271)3.84833364
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.82573157
32somatic diversification of immune receptors via somatic mutation (GO:0002566)3.81137645
33somatic hypermutation of immunoglobulin genes (GO:0016446)3.81137645
34ribosomal small subunit assembly (GO:0000028)3.80863930
35positive regulation of chromosome segregation (GO:0051984)3.78842711
36nuclear envelope disassembly (GO:0051081)3.72411225
37membrane disassembly (GO:0030397)3.72411225
38positive thymic T cell selection (GO:0045059)3.69070311
39DNA strand elongation (GO:0022616)3.65580043
40cellular protein complex disassembly (GO:0043624)3.65442813
41regulation of nuclear cell cycle DNA replication (GO:0033262)3.63834126
42determination of adult lifespan (GO:0008340)3.63801605
43nucleobase biosynthetic process (GO:0046112)3.63206007
44regulation of telomere maintenance via telomerase (GO:0032210)3.62643460
45histone H3-K4 trimethylation (GO:0080182)3.61666336
46negative regulation of histone methylation (GO:0031061)3.61288464
47viral life cycle (GO:0019058)3.60902201
48DNA geometric change (GO:0032392)3.60354762
49DNA duplex unwinding (GO:0032508)3.60317811
50formation of translation preinitiation complex (GO:0001731)3.60172648
51metaphase plate congression (GO:0051310)3.60020478
52negative regulation of erythrocyte differentiation (GO:0045647)3.57744255
53telomere maintenance via semi-conservative replication (GO:0032201)3.55129431
54protein K6-linked ubiquitination (GO:0085020)3.53423564
55thymic T cell selection (GO:0045061)3.52998347
56negative T cell selection (GO:0043383)3.51712338
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51365046
58regulation of histone H3-K4 methylation (GO:0051569)3.50665219
59protein targeting to ER (GO:0045047)3.49799798
60negative thymic T cell selection (GO:0045060)3.47513967
61cotranslational protein targeting to membrane (GO:0006613)3.47172107
62kinetochore organization (GO:0051383)3.47038225
63chromatin assembly (GO:0031497)3.45935216
64negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45910367
65meiotic chromosome segregation (GO:0045132)3.42137898
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.40384505
67folic acid-containing compound biosynthetic process (GO:0009396)3.38230429
68purine nucleobase biosynthetic process (GO:0009113)3.38097825
69protein complex disassembly (GO:0043241)3.36282899
70ribosome biogenesis (GO:0042254)3.35754800
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34381036
72IMP biosynthetic process (GO:0006188)3.34059359
73chromatin remodeling at centromere (GO:0031055)3.33393263
74pre-miRNA processing (GO:0031054)3.33004314
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.32836251
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.32836251
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.32836251
78tolerance induction (GO:0002507)3.30967130
79establishment of protein localization to endoplasmic reticulum (GO:0072599)3.30792588
80regulation of chromatin binding (GO:0035561)3.29818036
81mitotic sister chromatid cohesion (GO:0007064)3.28890505
82regulation of spindle organization (GO:0090224)3.28464821
83translational initiation (GO:0006413)3.27569491
84mitotic recombination (GO:0006312)3.27430357
85ribosome assembly (GO:0042255)3.26985801
86telomere maintenance via recombination (GO:0000722)3.23810026
87attachment of spindle microtubules to kinetochore (GO:0008608)3.22241915
88DNA replication-independent nucleosome assembly (GO:0006336)3.20920816
89DNA replication-independent nucleosome organization (GO:0034724)3.20920816
90mannose metabolic process (GO:0006013)3.20597526
91protein localization to chromosome (GO:0034502)3.20164215
92T cell selection (GO:0045058)3.19509106
93negative regulation of RNA splicing (GO:0033119)3.17710215
94chromatin assembly or disassembly (GO:0006333)3.14711580
95establishment of chromosome localization (GO:0051303)3.14685070
96kinetochore assembly (GO:0051382)3.14334234
97regulation of chromosome segregation (GO:0051983)3.14159805
98CENP-A containing nucleosome assembly (GO:0034080)3.12864521
99regulation of B cell receptor signaling pathway (GO:0050855)3.12513642
100DNA conformation change (GO:0071103)3.12486321
101replication fork processing (GO:0031297)3.12200518
102positive T cell selection (GO:0043368)3.12158937
103B cell receptor signaling pathway (GO:0050853)3.12089034
104regulation of double-strand break repair via homologous recombination (GO:0010569)3.11623632
105protein localization to endoplasmic reticulum (GO:0070972)3.11192740
106regulation of sister chromatid cohesion (GO:0007063)3.11077878
107microtubule depolymerization (GO:0007019)3.11000764
108positive regulation of histone H3-K4 methylation (GO:0051571)3.10358004
109regulation of mitotic spindle organization (GO:0060236)3.09484309
110regulation of centrosome cycle (GO:0046605)3.07974059
111macromolecular complex disassembly (GO:0032984)3.06909188
112regulation of gene silencing (GO:0060968)3.06057891
113regulation of histone H3-K27 methylation (GO:0061085)3.04793983
114telomere maintenance via telomere lengthening (GO:0010833)3.02699822
115chromosome segregation (GO:0007059)3.01793545
116histone H3-K4 methylation (GO:0051568)3.00859012
117regulation of gamma-delta T cell activation (GO:0046643)2.99728460
118positive regulation by host of viral transcription (GO:0043923)2.99514376
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99404209
120histone H4-K5 acetylation (GO:0043981)2.98978557
121histone H4-K8 acetylation (GO:0043982)2.98978557
122histone exchange (GO:0043486)2.98358430
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.96555726
124negative regulation of cell killing (GO:0031342)2.96555726
125negative regulation of mRNA processing (GO:0050686)2.95890696
126negative regulation of chromosome segregation (GO:0051985)2.95767380
127antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95733218
128chromosome condensation (GO:0030261)2.94609244
129regulation of RNA export from nucleus (GO:0046831)2.94450056
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.94097540
131regulation of gamma-delta T cell differentiation (GO:0045586)2.93714366
132maturation of SSU-rRNA (GO:0030490)2.93380729
133intra-S DNA damage checkpoint (GO:0031573)2.92731719
134histone H2A monoubiquitination (GO:0035518)2.92521005
135regulation of double-strand break repair (GO:2000779)2.91818493
136spindle assembly (GO:0051225)2.89407330
137mismatch repair (GO:0006298)2.89141518
138nuclear envelope organization (GO:0006998)2.88012159
139positive regulation of histone deacetylation (GO:0031065)2.87717402
140spindle checkpoint (GO:0031577)2.87684072
141histone H3-K36 demethylation (GO:0070544)2.87323934
142V(D)J recombination (GO:0033151)2.87154376
143antigen processing and presentation of endogenous antigen (GO:0019883)2.86873845
144cellular response to virus (GO:0098586)2.86170584
145ribonucleoprotein complex biogenesis (GO:0022613)2.85199428
146regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84835130
147dosage compensation (GO:0007549)2.84343067
148DNA topological change (GO:0006265)2.83793332
149IMP metabolic process (GO:0046040)2.82913530
150mRNA transport (GO:0051028)2.82719102
151regulation of translation in response to stress (GO:0043555)2.82487417
152regulation of histone methylation (GO:0031060)2.81998110
153nuclear-transcribed mRNA catabolic process (GO:0000956)2.81213524
154histone H4-K16 acetylation (GO:0043984)2.78725359
155negative regulation of mRNA metabolic process (GO:1903312)2.78568126
156negative regulation of T cell mediated immunity (GO:0002710)2.78442179
157mRNA splice site selection (GO:0006376)2.78115049
158mucosal-associated lymphoid tissue development (GO:0048537)2.76489426
159Peyers patch development (GO:0048541)2.76489426
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75452639
161mRNA catabolic process (GO:0006402)2.73970194
162RNA catabolic process (GO:0006401)2.71739070
163positive regulation of cell cycle checkpoint (GO:1901978)2.70638745
164folic acid metabolic process (GO:0046655)2.69731979
165positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66609278
166histone H4 deacetylation (GO:0070933)2.61833106
167CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.60413334
168positive regulation of CREB transcription factor activity (GO:0032793)2.60179644
169regulation of B cell differentiation (GO:0045577)2.54770364
170histone deubiquitination (GO:0016578)2.53478022
171response to muramyl dipeptide (GO:0032495)2.51535170
172positive regulation of granulocyte differentiation (GO:0030854)2.50848627
173positive regulation of protein deacetylation (GO:0090312)2.50649481
174peptidyl-lysine trimethylation (GO:0018023)2.50334927
175leukocyte aggregation (GO:0070486)2.49103569
176T cell lineage commitment (GO:0002360)2.45648560
177positive regulation of gene expression, epigenetic (GO:0045815)2.44585829
178histone phosphorylation (GO:0016572)2.44284012
1793-UTR-mediated mRNA stabilization (GO:0070935)2.43520511
180negative regulation of cell cycle G2/M phase transition (GO:1902750)2.41537336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.01353645
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.73728927
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.72312618
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.48997925
5VDR_21846776_ChIP-Seq_THP-1_Human3.28703215
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14341449
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.91422058
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.91422058
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.91422058
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.90408428
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.77587525
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.70158641
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69578172
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53185825
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.45093701
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.32767814
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23712479
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23025446
19* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.19722832
20NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.15572392
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12477490
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.04947114
23* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02147273
24MAF_26560356_Chip-Seq_TH1_Human1.99717801
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.99371778
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.95632391
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90615368
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.89440877
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.89164214
30MAF_26560356_Chip-Seq_TH2_Human1.88161791
31VDR_24763502_ChIP-Seq_THP-1_Human1.86728194
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.86341496
33* UTX_26944678_Chip-Seq_JUKART_Human1.86110975
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85044092
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.84083904
36* E2F1_21310950_ChIP-Seq_MCF-7_Human1.83173120
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82177869
38TCF7_22412390_ChIP-Seq_EML_Mouse1.81841436
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80020076
40* ETS1_20019798_ChIP-Seq_JURKAT_Human1.78077068
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75661103
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74723745
43XRN2_22483619_ChIP-Seq_HELA_Human1.74460708
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72078992
45KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.72063703
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71174240
47MYC_22102868_ChIP-Seq_BL_Human1.71166679
48* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.71062796
49AR_21909140_ChIP-Seq_LNCAP_Human1.70858532
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.69373924
51* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.69023292
52SOX2_18555785_ChIP-Seq_MESCs_Mouse1.69013699
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66121853
54KDM2B_26808549_Chip-Seq_DND41_Human1.64354402
55MYB_26560356_Chip-Seq_TH1_Human1.64072598
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.62900315
57VDR_23849224_ChIP-Seq_CD4+_Human1.61806387
58SCL_19346495_ChIP-Seq_HPC-7_Human1.60411617
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.59920673
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59184397
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57790817
62* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55808647
63MYB_26560356_Chip-Seq_TH2_Human1.55686964
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51745675
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.49426822
66KDM5A_27292631_Chip-Seq_BREAST_Human1.47595004
67NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.47283363
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47199179
69FOXP3_21729870_ChIP-Seq_TREG_Human1.47090175
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46952054
71GABP_17652178_ChIP-ChIP_JURKAT_Human1.46192772
72HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44899643
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44277073
74KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43745138
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.40911240
76P68_20966046_ChIP-Seq_HELA_Human1.40347040
77ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39668742
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.39378945
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39045792
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.38618642
81* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37488955
82SPI1_23547873_ChIP-Seq_NB4_Human1.37484989
83LXR_22292898_ChIP-Seq_THP-1_Human1.37268367
84SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.36471776
85* NANOG_21062744_ChIP-ChIP_HESCs_Human1.36356045
86SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36270085
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35867389
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35097774
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34959635
90TTF2_22483619_ChIP-Seq_HELA_Human1.34785151
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33581209
92DCP1A_22483619_ChIP-Seq_HELA_Human1.31526044
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31439474
94CIITA_25753668_ChIP-Seq_RAJI_Human1.31247064
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.28077477
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26339905
97* NCOR1_26117541_ChIP-Seq_K562_Human1.25567479
98GABP_19822575_ChIP-Seq_HepG2_Human1.24897784
99* YY1_21170310_ChIP-Seq_MESCs_Mouse1.24283379
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.23169863
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20102341
102* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.17690208
103NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16396226
104ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16042492
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15792731
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15594094
107* KDM2B_26808549_Chip-Seq_JURKAT_Human1.14738909
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14474901
109STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14340043
110* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13365957
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13242888
112RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13082836
113BCL6_27268052_Chip-Seq_Bcells_Human1.12521857
114IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09980374
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09542156
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08886394
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08586119
118* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.08310310
119* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08201213
120* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07861956
121RUNX_20019798_ChIP-Seq_JUKART_Human1.07822811
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.07701623
123BCOR_27268052_Chip-Seq_Bcells_Human1.07549522
124ELF1_20517297_ChIP-Seq_JURKAT_Human1.06212016
125* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05741411
126ELK1_19687146_ChIP-ChIP_HELA_Human1.05445501
127* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05337829
128TFEB_21752829_ChIP-Seq_HELA_Human1.05332232
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04976065
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04255986
131E2F1_20622854_ChIP-Seq_HELA_Human1.03739635
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02728392
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.00534330
134TET1_21451524_ChIP-Seq_MESCs_Mouse1.00074498
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99424111
136PHF8_20622854_ChIP-Seq_HELA_Human0.99105711
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99049465
138* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98939251
139SA1_27219007_Chip-Seq_ERYTHROID_Human0.98772183
140PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98735945
141ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98036719
142ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97754019
143GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97653731
144* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97374726
145* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95885699
146* KAP1_27257070_Chip-Seq_ESCs_Mouse0.95512620
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95456232
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94508552
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94424256
150CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93657289
151CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92861653
152TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.92317450
153* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91552279
154CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91446852
155PADI4_21655091_ChIP-ChIP_MCF-7_Human0.90316579
156HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.89619306
157* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84769638
158ZNF263_19887448_ChIP-Seq_K562_Human0.84522992
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83372931
160SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83133270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.93870506
2MP0003111_abnormal_nucleus_morphology4.52265207
3MP0010094_abnormal_chromosome_stability4.51497445
4MP0003693_abnormal_embryo_hatching4.32805833
5MP0004957_abnormal_blastocyst_morpholog4.23594979
6MP0003077_abnormal_cell_cycle3.66422478
7MP0008058_abnormal_DNA_repair3.13365460
8MP0004185_abnormal_adipocyte_glucose3.10630579
9MP0009379_abnormal_foot_pigmentation2.76749276
10MP0000685_abnormal_immune_system2.64208244
11MP0010352_gastrointestinal_tract_polyps2.58041839
12MP0008877_abnormal_DNA_methylation2.50015511
13MP0001800_abnormal_humoral_immune2.48890632
14MP0000350_abnormal_cell_proliferation2.36431632
15MP0001730_embryonic_growth_arrest2.34397966
16MP0003786_premature_aging2.29851841
17MP0010307_abnormal_tumor_latency2.25947231
18MP0001835_abnormal_antigen_presentation2.24130491
19MP0005671_abnormal_response_to2.23935579
20MP0008932_abnormal_embryonic_tissue2.23441909
21MP0001790_abnormal_immune_system2.18595397
22MP0005387_immune_system_phenotype2.18595397
23MP0003436_decreased_susceptibility_to2.15977035
24MP0001873_stomach_inflammation2.09504884
25MP0001672_abnormal_embryogenesis/_devel2.07588555
26MP0005380_embryogenesis_phenotype2.07588555
27MP0008007_abnormal_cellular_replicative2.04477408
28MP0002653_abnormal_ependyma_morphology1.98507863
29MP0002084_abnormal_developmental_patter1.88653009
30MP0002085_abnormal_embryonic_tissue1.85743543
31MP0002086_abnormal_extraembryonic_tissu1.83392147
32MP0003984_embryonic_growth_retardation1.80990486
33MP0003890_abnormal_embryonic-extraembry1.80448762
34MP0001697_abnormal_embryo_size1.79592665
35MP0005076_abnormal_cell_differentiation1.78276675
36* MP0002420_abnormal_adaptive_immunity1.78017223
37MP0002088_abnormal_embryonic_growth/wei1.77691254
38* MP0001819_abnormal_immune_cell1.76582214
39* MP0002723_abnormal_immune_serum1.74749202
40* MP0000716_abnormal_immune_system1.71737487
41MP0002452_abnormal_antigen_presenting1.70531850
42MP0002163_abnormal_gland_morphology1.70293818
43MP0004197_abnormal_fetal_growth/weight/1.69789875
44MP0003123_paternal_imprinting1.68647394
45MP0002210_abnormal_sex_determination1.65056258
46MP0002396_abnormal_hematopoietic_system1.62422077
47MP0002080_prenatal_lethality1.59577887
48* MP0002429_abnormal_blood_cell1.59559837
49MP0000490_abnormal_crypts_of1.56932409
50MP0005000_abnormal_immune_tolerance1.55950913
51MP0004381_abnormal_hair_follicle1.53759791
52MP0003718_maternal_effect1.52951831
53MP0001145_abnormal_male_reproductive1.52257092
54MP0001929_abnormal_gametogenesis1.51606478
55MP0003806_abnormal_nucleotide_metabolis1.50920803
56MP0004133_heterotaxia1.48123215
57* MP0005025_abnormal_response_to1.45530391
58MP0002405_respiratory_system_inflammati1.45272152
59MP0001293_anophthalmia1.41385539
60MP0006292_abnormal_olfactory_placode1.40808299
61MP0000313_abnormal_cell_death1.38709866
62MP0005083_abnormal_biliary_tract1.36472871
63MP0003943_abnormal_hepatobiliary_system1.35901821
64MP0003303_peritoneal_inflammation1.35568478
65MP0002277_abnormal_respiratory_mucosa1.33634254
66MP0010155_abnormal_intestine_physiology1.31242180
67MP0002019_abnormal_tumor_incidence1.30630322
68MP0001663_abnormal_digestive_system1.30122983
69MP0008995_early_reproductive_senescence1.29995922
70MP0003121_genomic_imprinting1.29138666
71MP0003646_muscle_fatigue1.26317076
72MP0005666_abnormal_adipose_tissue1.22791230
73MP0002132_abnormal_respiratory_system1.22741926
74MP0003866_abnormal_defecation1.22448440
75MP0002009_preneoplasia1.20046029
76MP0000653_abnormal_sex_gland1.19062880
77MP0002928_abnormal_bile_duct1.18936720
78MP0004264_abnormal_extraembryonic_tissu1.18906143
79MP0003136_yellow_coat_color1.16729857
80MP0003119_abnormal_digestive_system1.16580253
81MP0004947_skin_inflammation1.15741152
82MP0003705_abnormal_hypodermis_morpholog1.14595678
83MP0003567_abnormal_fetal_cardiomyocyte1.12866461
84MP0003698_abnormal_male_reproductive1.12768690
85MP0001919_abnormal_reproductive_system1.11504165
86MP0005410_abnormal_fertilization1.10063156
87MP0009278_abnormal_bone_marrow1.05245268
88MP0002419_abnormal_innate_immunity1.01628464
89MP0003941_abnormal_skin_development1.00050300
90MP0003315_abnormal_perineum_morphology0.99483879
91MP0001545_abnormal_hematopoietic_system0.98341742
92MP0005397_hematopoietic_system_phenotyp0.98341742
93MP0003566_abnormal_cell_adhesion0.95353853
94MP0005381_digestive/alimentary_phenotyp0.94753150
95MP0001849_ear_inflammation0.94085783
96MP0000703_abnormal_thymus_morphology0.92080850
97MP0009703_decreased_birth_body0.91260289
98MP0004808_abnormal_hematopoietic_stem0.91141436
99MP0009785_altered_susceptibility_to0.90207223
100MP0000678_abnormal_parathyroid_gland0.88930427
101MP0002092_abnormal_eye_morphology0.86985231
102MP0005621_abnormal_cell_physiology0.86365964
103MP0002160_abnormal_reproductive_system0.85710991
104MP0002722_abnormal_immune_system0.82653996
105MP0001845_abnormal_inflammatory_respons0.82325321
106MP0004043_abnormal_pH_regulation0.81950915
107MP0005384_cellular_phenotype0.81746723
108MP0005310_abnormal_salivary_gland0.81308692
109MP0003787_abnormal_imprinting0.81209165
110MP0002398_abnormal_bone_marrow0.80721193
111MP0000689_abnormal_spleen_morphology0.80624926
112MP0000470_abnormal_stomach_morphology0.80508817
113MP0005174_abnormal_tail_pigmentation0.80453494
114MP0002161_abnormal_fertility/fecundity0.80452481
115MP0005501_abnormal_skin_physiology0.80032913
116MP0010030_abnormal_orbit_morphology0.79558302
117MP0002166_altered_tumor_susceptibility0.78916677
118MP0005389_reproductive_system_phenotype0.78318383
119MP0005075_abnormal_melanosome_morpholog0.77616487
120MP0002111_abnormal_tail_morphology0.76983051
121MP0009115_abnormal_fat_cell0.75965070
122MP0000432_abnormal_head_morphology0.75435745
123MP0001915_intracranial_hemorrhage0.75395227
124MP0003172_abnormal_lysosome_physiology0.75040176
125MP0001188_hyperpigmentation0.75000467
126MP0003936_abnormal_reproductive_system0.74618999
127MP0001119_abnormal_female_reproductive0.74606571
128MP0003937_abnormal_limbs/digits/tail_de0.74053175
129MP0008961_abnormal_basal_metabolism0.72682660
130MP0009333_abnormal_splenocyte_physiolog0.72318948
131MP0001286_abnormal_eye_development0.71735704
132MP0002697_abnormal_eye_size0.71072599
133MP0005023_abnormal_wound_healing0.70953957
134MP0003763_abnormal_thymus_physiology0.70684365
135MP0009672_abnormal_birth_weight0.69098129
136MP0002148_abnormal_hypersensitivity_rea0.68422015
137MP0005379_endocrine/exocrine_gland_phen0.68240962
138MP0002249_abnormal_larynx_morphology0.68150004
139MP0008770_decreased_survivor_rate0.67353091
140MP0003861_abnormal_nervous_system0.66320104
141MP0000371_diluted_coat_color0.66014835
142MP0003448_altered_tumor_morphology0.65122242
143MP0003950_abnormal_plasma_membrane0.63801697
144MP0002925_abnormal_cardiovascular_devel0.63540229
145MP0005266_abnormal_metabolism0.63330517
146MP0000358_abnormal_cell_content/0.62258590
147MP0003699_abnormal_female_reproductive0.62041446
148MP0000477_abnormal_intestine_morphology0.61574048
149MP0003878_abnormal_ear_physiology0.61125890
150MP0005377_hearing/vestibular/ear_phenot0.61125890
151MP0000428_abnormal_craniofacial_morphol0.60145393
152MP0002075_abnormal_coat/hair_pigmentati0.59290838

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.06788614
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.81188862
3Chromsome breakage (HP:0040012)4.58761976
4Panhypogammaglobulinemia (HP:0003139)4.50391997
5Abnormality of cells of the erythroid lineage (HP:0012130)4.37370220
6Abnormal number of erythroid precursors (HP:0012131)4.10490766
7Impulsivity (HP:0100710)3.79106996
8Birth length less than 3rd percentile (HP:0003561)3.78171413
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.77511189
10Abnormality of the labia minora (HP:0012880)3.68739317
11Astrocytoma (HP:0009592)3.62374331
12Abnormality of the astrocytes (HP:0100707)3.62374331
13Pallor (HP:0000980)3.61706670
14Breast hypoplasia (HP:0003187)3.56318484
15Medulloblastoma (HP:0002885)3.50472362
16Absent radius (HP:0003974)3.40517003
17Meckel diverticulum (HP:0002245)3.40377724
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.40013154
19Abnormality of chromosome stability (HP:0003220)3.38145101
20Abnormality of the ileum (HP:0001549)3.38053062
21Agammaglobulinemia (HP:0004432)3.33592844
22Rhabdomyosarcoma (HP:0002859)3.32211181
23Abnormality of the preputium (HP:0100587)3.27465219
24Absent forearm bone (HP:0003953)3.23698425
25Aplasia involving forearm bones (HP:0009822)3.23698425
26Recurrent viral infections (HP:0004429)3.18644365
27Neoplasm of the oral cavity (HP:0100649)3.16927159
28Recurrent fungal infections (HP:0002841)3.16411605
29Rib fusion (HP:0000902)3.14818795
30Glioma (HP:0009733)3.14230997
31Patellar aplasia (HP:0006443)3.06777928
32Selective tooth agenesis (HP:0001592)3.06169195
33Supernumerary spleens (HP:0009799)3.05064285
34Recurrent cutaneous fungal infections (HP:0011370)3.04737769
35Chronic mucocutaneous candidiasis (HP:0002728)3.04737769
36Aplasia/Hypoplasia of the sacrum (HP:0008517)3.03276478
37Absent thumb (HP:0009777)2.96218843
38Acute lymphatic leukemia (HP:0006721)2.94626166
39Aplasia/hypoplasia of the humerus (HP:0006507)2.93366266
40Agnosia (HP:0010524)2.89834871
41Eczematoid dermatitis (HP:0000976)2.88566874
42Neoplasm of striated muscle (HP:0009728)2.87831540
43Aplasia/Hypoplasia of the patella (HP:0006498)2.81955124
44Duodenal stenosis (HP:0100867)2.77415110
45Small intestinal stenosis (HP:0012848)2.77415110
46Short humerus (HP:0005792)2.76478828
47Myelodysplasia (HP:0002863)2.67701290
48Severe combined immunodeficiency (HP:0004430)2.66929428
49Abnormality of the fingertips (HP:0001211)2.65210369
50Macrocytic anemia (HP:0001972)2.62073549
51Meningitis (HP:0001287)2.60903319
52Ectopic kidney (HP:0000086)2.60555867
53Recurrent bacterial skin infections (HP:0005406)2.60092912
54Duplicated collecting system (HP:0000081)2.57197917
55Volvulus (HP:0002580)2.56249520
56Reticulocytopenia (HP:0001896)2.55904965
57Carpal bone hypoplasia (HP:0001498)2.53141866
58Hypochromic anemia (HP:0001931)2.52763447
59Basal cell carcinoma (HP:0002671)2.52199493
60Missing ribs (HP:0000921)2.52130890
61Hypochromic microcytic anemia (HP:0004840)2.51273902
62Sloping forehead (HP:0000340)2.44904467
63Abnormality of the anterior horn cell (HP:0006802)2.43734902
64Degeneration of anterior horn cells (HP:0002398)2.43734902
65Homocystinuria (HP:0002156)2.43664257
66Abnormality of homocysteine metabolism (HP:0010919)2.43664257
67Lymphopenia (HP:0001888)2.40546886
68Abnormality of T cell physiology (HP:0011840)2.40279690
69Colitis (HP:0002583)2.40168774
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38968148
71Facial hemangioma (HP:0000329)2.38671406
72Gastrointestinal stroma tumor (HP:0100723)2.38064058
73Bone marrow hypocellularity (HP:0005528)2.35528293
74Rectal fistula (HP:0100590)2.35488709
75Rectovaginal fistula (HP:0000143)2.35488709
76Tetany (HP:0001281)2.35340966
77Shawl scrotum (HP:0000049)2.35023980
78Combined immunodeficiency (HP:0005387)2.33764784
79Nephroblastoma (Wilms tumor) (HP:0002667)2.33428971
80Prominent nose (HP:0000448)2.33107617
81Abnormality of T cells (HP:0002843)2.32664084
82Premature ovarian failure (HP:0008209)2.32345330
83Colon cancer (HP:0003003)2.31976920
84Cafe-au-lait spot (HP:0000957)2.31057322
85Abnormality of DNA repair (HP:0003254)2.30806652
86Abnormality of the duodenum (HP:0002246)2.30591343
87IgG deficiency (HP:0004315)2.30211152
88Intestinal fistula (HP:0100819)2.29421358
89Diastasis recti (HP:0001540)2.28372912
90Neonatal hypoglycemia (HP:0001998)2.27549624
91Abnormality of the lower motor neuron (HP:0002366)2.24915717
92Abnormality of cells of the lymphoid lineage (HP:0012140)2.24776127
93Abnormality of reticulocytes (HP:0004312)2.20877465
94Rectal prolapse (HP:0002035)2.20419960
95Tracheoesophageal fistula (HP:0002575)2.18850497
96Squamous cell carcinoma (HP:0002860)2.17636221
97Aplasia/Hypoplasia of the thymus (HP:0010515)2.17298346
98Abnormality of abdominal situs (HP:0011620)2.16153861
99Abdominal situs inversus (HP:0003363)2.16153861
100Recurrent skin infections (HP:0001581)2.14729060
101Recurrent abscess formation (HP:0002722)2.14591392
102Abnormality of the carotid arteries (HP:0005344)2.14223791
103Tongue fasciculations (HP:0001308)2.13842398
104Embryonal renal neoplasm (HP:0011794)2.12622238
105Abnormality of the renal collecting system (HP:0004742)2.11008490
106Supernumerary bones of the axial skeleton (HP:0009144)2.10536275
107Supernumerary ribs (HP:0005815)2.10078230
108Rough bone trabeculation (HP:0100670)2.08998661
109Short thumb (HP:0009778)2.08306266
110Clubbing of toes (HP:0100760)2.08021630
111Proximal placement of thumb (HP:0009623)2.06655538
112Horseshoe kidney (HP:0000085)2.05221584
113Pustule (HP:0200039)2.04463267
114Deep palmar crease (HP:0006191)2.04333089
115Oral leukoplakia (HP:0002745)2.04201007
116Gastrointestinal inflammation (HP:0004386)2.03423954
117Triphalangeal thumb (HP:0001199)2.01845124
118Abnormality of the salivary glands (HP:0010286)2.01438583
119Multiple enchondromatosis (HP:0005701)2.00847427
120Heterotopia (HP:0002282)2.00638072
121IgA deficiency (HP:0002720)2.00455111
122T lymphocytopenia (HP:0005403)1.99212407
123Abnormal number of incisors (HP:0011064)1.99097137
124Encephalitis (HP:0002383)1.98950285
125Verrucae (HP:0200043)1.97510248
126Papilloma (HP:0012740)1.97510248
127Mediastinal lymphadenopathy (HP:0100721)1.95828158
128Ureteral duplication (HP:0000073)1.95785411
129Deviation of the thumb (HP:0009603)1.95023556
130Lymphoma (HP:0002665)1.94646631
131Anal stenosis (HP:0002025)1.94016993
132Gastrointestinal infarctions (HP:0005244)1.93701548
13311 pairs of ribs (HP:0000878)1.92535226
134Leukopenia (HP:0001882)1.91407111
135Spinal muscular atrophy (HP:0007269)1.90470500
136Neoplasm of the pancreas (HP:0002894)1.89662071
137Atresia of the external auditory canal (HP:0000413)1.89503044
138Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89257431
139Aplasia/Hypoplasia of the sternum (HP:0006714)1.87925885
140Elevated erythrocyte sedimentation rate (HP:0003565)1.87122126
141Biliary tract neoplasm (HP:0100574)1.86209429
142Obstructive lung disease (HP:0006536)1.86120715
143Chronic obstructive pulmonary disease (HP:0006510)1.86120715
144Increased nuchal translucency (HP:0010880)1.85907361
145Muscle fibrillation (HP:0010546)1.85740092
146Inflammation of the large intestine (HP:0002037)1.85278342
147Abnormal lung lobation (HP:0002101)1.84872174
148Abnormality of chromosome segregation (HP:0002916)1.84003001
149Vasculitis (HP:0002633)1.83886266
150Gastrointestinal carcinoma (HP:0002672)1.82925747
151Malignant gastrointestinal tract tumors (HP:0006749)1.82925747
152Vaginal fistula (HP:0004320)1.82902096
153Esophageal atresia (HP:0002032)1.82788991
154Aplasia/Hypoplasia of the spleen (HP:0010451)1.82186589
155Trismus (HP:0000211)1.81598309
156Asplenia (HP:0001746)1.81373319
157Amaurosis fugax (HP:0100576)1.81142610
158Prolonged bleeding time (HP:0003010)1.80438090
159Respiratory difficulties (HP:0002880)1.80032606
160Abnormality of small intestinal villus morphology (HP:0011472)1.79596179
161Villous atrophy (HP:0011473)1.79596179
162Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78282022
163Increased IgE level (HP:0003212)1.78109809
164Optic nerve coloboma (HP:0000588)1.74333848
165Hypoplasia of the radius (HP:0002984)1.74096450
166Broad distal phalanx of finger (HP:0009836)1.73846199
167Ileus (HP:0002595)1.73208605
168Chronic otitis media (HP:0000389)1.69452192

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.27553504
2TRIB34.25594111
3WEE14.18663618
4CDC73.82337560
5BUB13.21496841
6NEK23.05668312
7TTK2.98768240
8EPHA22.71772842
9SMG12.70656283
10PRPF4B2.61561590
11ERN12.46987365
12SRPK12.23743067
13CDK72.20375371
14RIPK42.18195667
15AKT32.17892151
16PLK12.17077449
17NEK12.01676513
18MAP3K131.99403128
19CHEK21.97035126
20RPS6KB21.89953790
21MAP2K31.81834909
22CDK41.80913842
23TSSK61.77573053
24ICK1.76853635
25EIF2AK11.74625584
26BRD41.72152205
27TYK21.66868541
28ATR1.66547807
29PNCK1.62549977
30IRAK41.61160921
31STK101.56842494
32CHEK11.53760818
33TLK11.53323216
34MAP3K141.52690951
35DYRK31.52358277
36AURKB1.50546393
37BTK1.50222275
38FGFR41.45326790
39STK41.44013341
40MAP2K21.42177829
41EEF2K1.41068225
42PIM11.40596920
43MKNK21.37923070
44TESK21.36579169
45PLK31.31266533
46IKBKE1.30996826
47ZAK1.29265259
48SIK21.24445125
49SIK11.22774201
50BRSK21.20771469
51MAP3K101.20638358
52CDC42BPA1.20587369
53ATM1.17269497
54AURKA1.17125074
55MAP3K81.16171169
56ZAP701.14820977
57GRK61.14231756
58NLK1.14081957
59ALK1.13547571
60CDK21.13425766
61EIF2AK31.12180602
62MKNK11.11189352
63VRK21.10843049
64SYK1.10752017
65MARK21.10091581
66NME11.09212615
67TAF11.07415020
68VRK11.07136382
69MAP3K71.06852525
70PDK31.04910280
71PDK41.04910280
72STK31.04680857
73PLK41.04070068
74CDK61.01560123
75PTK61.01550788
76ACVR1B0.99872135
77PASK0.97949041
78TYRO30.97654365
79TAOK30.96686251
80ITK0.94608752
81MAPK110.92571889
82MTOR0.91885647
83STK38L0.89118623
84FGFR20.89114546
85IKBKB0.88245076
86TEC0.85773090
87TXK0.83334143
88CDK10.82537210
89FGFR30.81606086
90JAK30.81094336
91TNK20.79484871
92PRKCI0.78122807
93MAPK150.77393345
94IRAK20.76593106
95PRKD20.76545407
96SCYL20.74887596
97PDK20.74821511
98LYN0.73740777
99HIPK20.71712969
100PDK10.71393669
101PAK40.70579099
102TBK10.70394296
103LCK0.69501900
104HCK0.68798493
105BLK0.68329435
106CSNK1D0.66120013
107LATS20.65754910
108RPS6KA60.65164866
109STK110.64112379
110CSNK2A20.63642281
111KSR20.63244401
112CDK30.62486522
113CDK80.61742577
114BRSK10.61584531
115YES10.60680603
116RPS6KA40.60015808
117LATS10.59582312
118IRAK10.59114749
119MAP2K60.58771203
120MELK0.58696557
121IRAK30.57668302
122CAMKK10.57105111
123MAPK120.56961956
124PAK10.56049007
125RPS6KL10.55518183
126RPS6KC10.55518183
127MAP4K10.55074933
128NUAK10.54690165
129FES0.54434417
130MATK0.54080915
131CSNK1E0.52620440
132PRKCQ0.52211106
133KIT0.51500011
134CSNK2A10.49751243
135NME20.49203836
136CAMK1D0.48938764
137LRRK20.48228243
138STK160.48176216
139MAPK140.46689166
140MARK30.44422898
141PRKDC0.44057737
142CSK0.43593812
143MAPKAPK30.43004937
144EIF2AK20.41753509
145AKT20.41002417
146BMX0.40648046
147GSK3B0.39630221
148CSF1R0.38690611
149MAPK10.37833895
150RPS6KA50.36682408
151CDK90.35965423
152CLK10.32427178
153CHUK0.31445711
154FLT30.31241433
155AKT10.30035638
156PKN20.29241530
157MAPK100.28222740
158STK380.27219119
159CCNB10.26734097
160MAP3K60.26604306
161DYRK1B0.25832180
162MET0.24030712
163PAK20.23022498
164FGR0.22693539
165MST40.20074259

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44392478
2Mismatch repair_Homo sapiens_hsa034304.41394534
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.08804361
4RNA transport_Homo sapiens_hsa030133.43156929
5Spliceosome_Homo sapiens_hsa030403.15078971
6Homologous recombination_Homo sapiens_hsa034403.10374337
7Base excision repair_Homo sapiens_hsa034102.99917076
8Fanconi anemia pathway_Homo sapiens_hsa034602.92230549
9One carbon pool by folate_Homo sapiens_hsa006702.84111734
10Cell cycle_Homo sapiens_hsa041102.79555726
11Nucleotide excision repair_Homo sapiens_hsa034202.73580761
12RNA polymerase_Homo sapiens_hsa030202.46031692
13mRNA surveillance pathway_Homo sapiens_hsa030152.29128127
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.27132242
15Non-homologous end-joining_Homo sapiens_hsa034502.18268305
16Basal transcription factors_Homo sapiens_hsa030222.09846692
17Ribosome_Homo sapiens_hsa030102.00295717
18p53 signaling pathway_Homo sapiens_hsa041151.89384155
19T cell receptor signaling pathway_Homo sapiens_hsa046601.81157982
20Pyrimidine metabolism_Homo sapiens_hsa002401.78343407
21RNA degradation_Homo sapiens_hsa030181.77034160
22Non-small cell lung cancer_Homo sapiens_hsa052231.73760617
23Vitamin B6 metabolism_Homo sapiens_hsa007501.71113965
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.68428766
25Proteasome_Homo sapiens_hsa030501.65801857
26Leishmaniasis_Homo sapiens_hsa051401.55982195
27Asthma_Homo sapiens_hsa053101.54089320
28Allograft rejection_Homo sapiens_hsa053301.51765487
29Graft-versus-host disease_Homo sapiens_hsa053321.49787875
30Autoimmune thyroid disease_Homo sapiens_hsa053201.39761455
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37945615
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.32510116
33Systemic lupus erythematosus_Homo sapiens_hsa053221.27450285
34Hepatitis C_Homo sapiens_hsa051601.18297746
35Viral carcinogenesis_Homo sapiens_hsa052031.13626724
36Osteoclast differentiation_Homo sapiens_hsa043801.10683621
37Epstein-Barr virus infection_Homo sapiens_hsa051691.09992784
38Other glycan degradation_Homo sapiens_hsa005111.08579159
39VEGF signaling pathway_Homo sapiens_hsa043701.06668246
40Herpes simplex infection_Homo sapiens_hsa051681.06110429
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04612890
42Oocyte meiosis_Homo sapiens_hsa041141.01144404
43Antigen processing and presentation_Homo sapiens_hsa046120.99664042
44Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96414535
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.95314553
46Selenocompound metabolism_Homo sapiens_hsa004500.93828503
47MicroRNAs in cancer_Homo sapiens_hsa052060.93029304
48Pancreatic cancer_Homo sapiens_hsa052120.91497111
49Choline metabolism in cancer_Homo sapiens_hsa052310.90806376
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90407105
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89887730
52Purine metabolism_Homo sapiens_hsa002300.89253675
53Pentose phosphate pathway_Homo sapiens_hsa000300.87143123
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.85741517
55Toxoplasmosis_Homo sapiens_hsa051450.84992511
56Prolactin signaling pathway_Homo sapiens_hsa049170.84647569
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84210523
58Primary immunodeficiency_Homo sapiens_hsa053400.82699646
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.81192490
60HTLV-I infection_Homo sapiens_hsa051660.80275857
61Type I diabetes mellitus_Homo sapiens_hsa049400.78982366
62mTOR signaling pathway_Homo sapiens_hsa041500.78892684
63Small cell lung cancer_Homo sapiens_hsa052220.78404781
64Chemokine signaling pathway_Homo sapiens_hsa040620.77515269
65Notch signaling pathway_Homo sapiens_hsa043300.77228771
66Biosynthesis of amino acids_Homo sapiens_hsa012300.77173774
67African trypanosomiasis_Homo sapiens_hsa051430.76503556
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75410595
69Dorso-ventral axis formation_Homo sapiens_hsa043200.73703208
70Hippo signaling pathway_Homo sapiens_hsa043900.72754054
71Renal cell carcinoma_Homo sapiens_hsa052110.69516665
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.69156462
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68882655
74Basal cell carcinoma_Homo sapiens_hsa052170.68257615
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.66986584
76Lysine degradation_Homo sapiens_hsa003100.66662008
77Fructose and mannose metabolism_Homo sapiens_hsa000510.66430202
78TNF signaling pathway_Homo sapiens_hsa046680.66077901
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.64613224
80Endometrial cancer_Homo sapiens_hsa052130.64232600
81Staphylococcus aureus infection_Homo sapiens_hsa051500.63591067
82Folate biosynthesis_Homo sapiens_hsa007900.62580629
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62238290
84Thyroid cancer_Homo sapiens_hsa052160.61390127
85Tuberculosis_Homo sapiens_hsa051520.57492983
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.57171196
87Colorectal cancer_Homo sapiens_hsa052100.55770234
88TGF-beta signaling pathway_Homo sapiens_hsa043500.54221395
89Adherens junction_Homo sapiens_hsa045200.53941511
90MAPK signaling pathway_Homo sapiens_hsa040100.53329591
91Insulin resistance_Homo sapiens_hsa049310.51023034
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.49974103
93Hedgehog signaling pathway_Homo sapiens_hsa043400.47583489
94Apoptosis_Homo sapiens_hsa042100.47419306
95Vitamin digestion and absorption_Homo sapiens_hsa049770.46900084
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45906157
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.45074200
98Prostate cancer_Homo sapiens_hsa052150.44584083
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.44110641
100ErbB signaling pathway_Homo sapiens_hsa040120.43483380
101Drug metabolism - other enzymes_Homo sapiens_hsa009830.42484205
102Regulation of autophagy_Homo sapiens_hsa041400.42032272
103Pathways in cancer_Homo sapiens_hsa052000.42010852
104Acute myeloid leukemia_Homo sapiens_hsa052210.39348100
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.38758829
106Fatty acid biosynthesis_Homo sapiens_hsa000610.36886007
107Glioma_Homo sapiens_hsa052140.36532499
108Alcoholism_Homo sapiens_hsa050340.36228639
109Bladder cancer_Homo sapiens_hsa052190.35522076
110Hepatitis B_Homo sapiens_hsa051610.34720779
111Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33667812
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33602495
113Legionellosis_Homo sapiens_hsa051340.32594901
114Measles_Homo sapiens_hsa051620.32151006
115Glutathione metabolism_Homo sapiens_hsa004800.32018880
116Tight junction_Homo sapiens_hsa045300.31882177
117Influenza A_Homo sapiens_hsa051640.30645862
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29594550
119Chronic myeloid leukemia_Homo sapiens_hsa052200.29102753
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.27732075
121Wnt signaling pathway_Homo sapiens_hsa043100.26982224
122Linoleic acid metabolism_Homo sapiens_hsa005910.26330305
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25777693
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25033833
125Inositol phosphate metabolism_Homo sapiens_hsa005620.23845536
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23209853
127Hematopoietic cell lineage_Homo sapiens_hsa046400.22172693
128FoxO signaling pathway_Homo sapiens_hsa040680.21821531
129Arachidonic acid metabolism_Homo sapiens_hsa005900.21649716
130B cell receptor signaling pathway_Homo sapiens_hsa046620.20958562
131Viral myocarditis_Homo sapiens_hsa054160.20285849
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20206381
133Carbon metabolism_Homo sapiens_hsa012000.19690057
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19429191
135Intestinal immune network for IgA production_Homo sapiens_hsa046720.19274930
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18989492
137Sulfur relay system_Homo sapiens_hsa041220.18779681
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18731259
139HIF-1 signaling pathway_Homo sapiens_hsa040660.18476992
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18112072
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17956846
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.17830695

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